Page last updated: 2024-08-07 23:20:25
Carbonyl reductase [NADPH] 1
A carbonyl reductase [NADPH] 1 that is encoded in the genome of human. [PRO:DNx]
Synonyms
EC 1.1.1.184;
15-hydroxyprostaglandin dehydrogenase [NADP(+)];
1.1.1.196;
1.1.1.197;
20-beta-hydroxysteroid dehydrogenase;
NADPH-dependent carbonyl reductase 1;
Prostaglandin 9-ketoreductase;
PG-9-KR;
Prostaglandin-E(2) 9-
Research
Bioassay Publications (3)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (8)
Drugs with Inhibition Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| haloperidol | Homo sapiens (human) | Km | 1,200.0000 | 1 | 1 |
| daunorubicin | Homo sapiens (human) | Km | 79.5000 | 2 | 2 |
Enables
This protein enables 8 target(s):
| Target | Category | Definition |
|---|
| carbonyl reductase (NADPH) activity | molecular function | Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+. [EC:1.1.1.184] |
| alcohol dehydrogenase (NADP+) activity | molecular function | Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+. [EC:1.1.1.2] |
| oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | molecular function | Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. [EC:1.1.1.-, GOC:ai] |
| oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | molecular function | Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. [GOC:ai] |
| 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity | molecular function | Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate. [EC:1.1.1.196, MetaCyc:1.1.1.196-RXN] |
| 15-hydroxyprostaglandin dehydrogenase (NADP+) activity | molecular function | Catalysis of the reaction: NADP+ + prostaglandin E(1) = 15-dehydro-prostaglandin E1 + H+ + NADPH. [EC:1.1.1.197, RHEA:11636] |
| prostaglandin-E2 9-reductase activity | molecular function | Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH. [EC:1.1.1.189, MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN] |
| S-nitrosoglutathione reductase (NADPH) activity | molecular function | Catalysis of the reaction: H+ + NADPH + S-nitrosoglutathione = NADP+ + S-(hydroxysulfenamide)glutathione. [RHEA:63500] |
Located In
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
| extracellular vesicle | cellular component | Any vesicle that is part of the extracellular region. [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] |
Involved In
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|
| xenobiotic metabolic process | biological process | The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc] |
| glucocorticoid metabolic process | biological process | The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. [ISBN:0198506732] |
| cyclooxygenase pathway | biological process | The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2. [PMID:19854273] |
| epithelial cell differentiation | biological process | The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. [GOC:ecd, PMID:11839751] |
| vitamin K metabolic process | biological process | The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule. [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] |
| positive regulation of reactive oxygen species metabolic process | biological process | Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process. [GOC:mah] |