Tyrosine-protein phosphatase non-receptor type 11

A tyrosine-protein phosphatase non-receptor type 11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q06124]

Synonyms

EC 3.1.3.48;
Protein-tyrosine phosphatase 1D;
PTP-1D;
Protein-tyrosine phosphatase 2C;
PTP-2C;
SH-PTP2;
SHP-2;
Shp2;
SH-PTP3

Research

Bioassay Publications (25)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (4.00)	18.2507
2000's	4 (16.00)	29.6817
2010's	15 (60.00)	24.3611
2020's	5 (20.00)	2.80

Compounds (24)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
glycyrrhetinic acid	Homo sapiens (human)	IC50	9.6000	2	2
oxanilic acid	Homo sapiens (human)	IC50	100.0000	1	1
oleanolic acid	Homo sapiens (human)	IC50	34.4375	3	4
vanadates	Homo sapiens (human)	IC50	22.5633	1	3
maslinic acid	Homo sapiens (human)	IC50	40.0000	1	1
nsc-87877	Homo sapiens (human)	IC50	0.3190	4	4
tingenone	Homo sapiens (human)	IC50	61.6000	1	1
geniposide	Homo sapiens (human)	IC50	500.0000	1	1
tanshinone	Homo sapiens (human)	IC50	2.5700	1	1
celastrol	Homo sapiens (human)	IC50	3.5667	3	3
cryptotanshinone	Homo sapiens (human)	IC50	28.5200	4	4
tanshinone ii a	Homo sapiens (human)	IC50	2.5900	1	1
nsc-89199	Homo sapiens (human)	IC50	17.1000	2	2
estramustine	Homo sapiens (human)	IC50	300.0000	1	1
genipin	Homo sapiens (human)	IC50	500.0000	1	1
cefsulodin	Homo sapiens (human)	IC50	16.8000	1	1
cefsulodin	Homo sapiens (human)	Ki	6.6000	1	1
nsc 117199	Homo sapiens (human)	IC50	32.9300	3	3
illudalic acid	Homo sapiens (human)	IC50	29.0000	1	1
2-amino-6-chloropurine	Homo sapiens (human)	IC50	75.9400	1	5
4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid	Homo sapiens (human)	IC50	2.1000	2	2
Dihydrotanshinone I	Homo sapiens (human)	IC50	3.9400	1	1
3-(1-(3-(biphenyl-4-ylamino)-3-oxopropyl)-1h-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1h-indole-5-carboxylic acid	Homo sapiens (human)	IC50	9.9222	8	9
3-(1-(3-(biphenyl-4-ylamino)-3-oxopropyl)-1h-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1h-indole-5-carboxylic acid	Homo sapiens (human)	Ki	5.2000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
nsc-89199	Homo sapiens (human)	Kd	8.4000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
phosphotyrosine	Homo sapiens (human)	ID50	33,000.0000	1	1
4-methylumbelliferyl phosphate	Homo sapiens (human)	Km	1,100.0000	1	1
cryptotanshinone	Homo sapiens (human)	Km	170.0000	1	1
nsc-89199	Homo sapiens (human)	Kii	10.8000	1	1
nsc-89199	Homo sapiens (human)	Kis	22.8000	1	1

Enables

This protein enables 14 target(s):

Target	Category	Definition
phosphotyrosine residue binding	molecular function	Binding to a phosphorylated tyrosine residue within a protein. [PMID:14636584]
phosphoprotein phosphatase activity	molecular function	Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity. [ISBN:0198547684]
protein tyrosine phosphatase activity	molecular function	Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48]
non-membrane spanning protein tyrosine phosphatase activity	molecular function	Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate. [EC:3.1.3.48]
insulin receptor binding	molecular function	Binding to an insulin receptor. [GOC:ai]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
protein kinase binding	molecular function	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]
signaling receptor complex adaptor activity	molecular function	The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex. [GOC:mah]
cadherin binding	molecular function	Binding to cadherin, a type I membrane protein involved in cell adhesion. [GOC:bf]
cell adhesion molecule binding	molecular function	Binding to a cell adhesion molecule. [GOC:ai]
peptide hormone receptor binding	molecular function	Binding to a receptor for a peptide hormone. [GOC:ai]
molecular adaptor activity	molecular function	The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. [GOC:mtg_MIT_16mar07, GOC:vw]
protein tyrosine kinase binding	molecular function	Binding to protein tyrosine kinase. [PMID:25499537]
receptor tyrosine kinase binding	molecular function	Binding to a receptor that possesses protein tyrosine kinase activity. [GOC:mah]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
protein-containing complex	cellular component	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]

Involved In

This protein is involved in 54 target(s):

Target	Category	Definition
DNA damage checkpoint signaling	biological process	A signal transduction process that contributes to a DNA damage checkpoint. [GOC:mah]
protein dephosphorylation	biological process	The process of removing one or more phosphoric residues from a protein. [GOC:hb]
triglyceride metabolic process	biological process	The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins. [ISBN:0198506732]
epidermal growth factor receptor signaling pathway	biological process	The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:ceb]
integrin-mediated signaling pathway	biological process	The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]
axonogenesis	biological process	De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells. [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
brain development	biological process	The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
heart development	biological process	The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. [GOC:jid, UBERON:0000948]
fibroblast growth factor receptor signaling pathway	biological process	The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. [GOC:ceb]
hormone-mediated signaling pathway	biological process	The series of molecular signals mediated by the detection of a hormone. [GOC:sm]
cytokine-mediated signaling pathway	biological process	The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling, PMID:19295629]
cerebellar cortex formation	biological process	The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
platelet formation	biological process	The process in which platelets bud from long processes extended by megakaryocytes. [GOC:mah, ISBN:0815316194]
T cell costimulation	biological process	The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation. [ISBN:0781735149]
negative regulation of chondrocyte differentiation	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation. [GOC:mah]
negative regulation of type I interferon production	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. [GOC:add, GOC:mah]
microvillus organization	biological process	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. [GOC:mah]
positive regulation of interferon-beta production	biological process	Any process that activates or increases the frequency, rate, or extent of interferon-beta production. [GOC:mah, PMID:15546383]
positive regulation of interleukin-6 production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. [GOC:mah]
positive regulation of tumor necrosis factor production	biological process	Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production. [GO_REF:0000058, GOC:TermGenie, PMID:10891884, PMID:15560120]
regulation of cell adhesion mediated by integrin	biological process	Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin. [GOC:add]
negative regulation of cell adhesion mediated by integrin	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of cell adhesion mediated by integrin. [GOC:add]
multicellular organism growth	biological process	The increase in size or mass of an entire multicellular organism, as opposed to cell growth. [GOC:bf, GOC:curators, GOC:dph, GOC:tb]
organ growth	biological process	The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function. [GOC:bf, ISBN:0471245208, ISBN:0721662544]
peptidyl-tyrosine dephosphorylation	biological process	The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine. [GOC:bf]
megakaryocyte development	biological process	The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow. [CL:0000556, GOC:BHF, GOC:vk]
atrioventricular canal development	biological process	The progression of the atrioventricular canal over time, from its formation to the mature structure. The atrioventricular canal is the part of the heart connecting the atrium to the cardiac ventricle. [GOC:BHF, GOC:gr, PMID:14701881, UBERON:0002087, ZFA:0001315]
ERBB signaling pathway	biological process	The series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:jc, PMID:16460914, Wikipedia:ErbB]
hormone metabolic process	biological process	The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. [GOC:jl]
glucose homeostasis	biological process	Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. [GOC:go_curators]
regulation of protein-containing complex assembly	biological process	Any process that modulates the frequency, rate or extent of protein complex assembly. [GOC:jl]
positive regulation of ossification	biological process	Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. [GOC:go_curators]
positive regulation of mitotic cell cycle	biological process	Any process that activates or increases the rate or extent of progression through the mitotic cell cycle. [GOC:dph, GOC:go_curators, GOC:tb]
positive regulation of glucose import	biological process	Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. [GOC:ai, GOC:dph, GOC:tb]
positive regulation of insulin receptor signaling pathway	biological process	Any process that increases the frequency, rate or extent of insulin receptor signaling. [GOC:bf]
negative regulation of insulin secretion	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. [GOC:ai]
regulation of protein export from nucleus	biological process	Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm. [GOC:bf]
positive regulation of hormone secretion	biological process	Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell. [GOC:ai]
platelet-derived growth factor receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to a platelet-derived growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb]
neurotrophin TRK receptor signaling pathway	biological process	The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:ceb, GOC:jc, GOC:signaling, PMID:12065629, Wikipedia:Trk_receptor]
ephrin receptor signaling pathway	biological process	The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb]
multicellular organismal reproductive process	biological process	The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs. [GOC:dph, GOC:jid, GOC:tb]
genitalia development	biological process	The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure. [GOC:jid]
inner ear development	biological process	The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure. [GOC:sr]
homeostasis of number of cells within a tissue	biological process	Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue. [GOC:isa_complete]
positive regulation of peptidyl-tyrosine phosphorylation	biological process	Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. [GOC:ai]
negative regulation of cortisol secretion	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cortisol from a cell. [GOC:ai]
Bergmann glial cell differentiation	biological process	The process in which neuroepithelial cells of the neural tube give rise to Brgmann glial cells, specialized bipotential progenitors cells of the cerebellum. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GOC:dph, PMID:10375501]
negative regulation of growth hormone secretion	biological process	Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell. [GOC:dph]
face morphogenesis	biological process	The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head. [GOC:dph]
regulation of type I interferon-mediated signaling pathway	biological process	Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway. [GOC:dph]
intestinal epithelial cell migration	biological process	The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism. [GOC:dph]
positive regulation of ERK1 and ERK2 cascade	biological process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah]
cellular response to epidermal growth factor stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. [GOC:mah]