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Histone deacetylase 6
A histone deacetylase 6 that is encoded in the genome of mouse. [OMA:Q9Z2V5, PRO:DNx]
Synonyms
HD6;
EC 3.5.1.98;
Histone deacetylase mHDA2;
Tubulin-lysine deacetylase HDAC6;
3.5.1.-
Research
Bioassay Publications (12)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
Compounds (4)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| vorinostat | Mus musculus (house mouse) | IC50 | 0.3742 | 2 | 5 |
| trichostatin a | Mus musculus (house mouse) | IC50 | 0.0387 | 7 | 7 |
| romidepsin | Mus musculus (house mouse) | IC50 | 0.3143 | 4 | 5 |
| tubastatin a | Mus musculus (house mouse) | IC50 | 0.0044 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| tubastatin a | Mus musculus (house mouse) | EC50 | 0.1450 | 1 | 1 |
Synthesis and biological evaluation of histone deacetylase and DNA topoisomerase II-Targeted inhibitors.Bioorganic & medicinal chemistry, , 05-01, Volume: 26, Issue:8, 2018
HDAC as onco target: Reviewing the synthetic approaches with SAR study of their inhibitors.European journal of medicinal chemistry, , Oct-05, Volume: 158, 2018
Design and synthesis of CHAP31, trapoxin B and HC-toxin based bicyclic tetrapeptides disulfide as potent histone deacetylase inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 22, Issue:15, 2014
Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework.Bioorganic & medicinal chemistry, , Dec-15, Volume: 15, Issue:24, 2007
Design, synthesis, structure--selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors.Journal of medicinal chemistry, , Nov-01, Volume: 50, Issue:22, 2007
Synthesis and histone deacetylase inhibitory activity of cyclic tetrapeptides containing a retrohydroxamate as zinc ligand.Bioorganic & medicinal chemistry letters, , May-17, Volume: 14, Issue:10, 2004
Histone deacetylase inhibitors.Journal of medicinal chemistry, , Nov-20, Volume: 46, Issue:24, 2003
Design and synthesis of CHAP31, trapoxin B and HC-toxin based bicyclic tetrapeptides disulfide as potent histone deacetylase inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 22, Issue:15, 2014
Total synthesis of burkholdacs A and B and 5,6,20-tri-epi-burkholdac A: HDAC inhibition and antiproliferative activity.European journal of medicinal chemistry, , Apr-09, Volume: 76, 2014
Total synthesis of bicyclic depsipeptides spiruchostatins C and D and investigation of their histone deacetylase inhibitory and antiproliferative activities.European journal of medicinal chemistry, , Volume: 60, 2013
The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor.Journal of medicinal chemistry, , Nov-15, Volume: 50, Issue:23, 2007