A sodium/hydrogen exchanger 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UBY0]
Na(+)/H(+) exchanger 2;
NHE-2;
Solute carrier family 9 member 2
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| cariporide | Homo sapiens (human) | IC50 | 27.6000 | 6 | 3 |
| eniporide | Homo sapiens (human) | IC50 | 8.2000 | 6 | 3 |
| zoniporide | Homo sapiens (human) | IC50 | 12.0000 | 4 | 1 |
This protein enables 2 target(s):
| Target | Category | Definition |
|---|---|---|
| sodium:proton antiporter activity | molecular function | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). [TC:2.A.35.1.1, TC:2.A.36.-.-] |
| potassium:proton antiporter activity | molecular function | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in). [TC:2.A.37.-.-] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is involved in 7 target(s):
| Target | Category | Definition |
|---|---|---|
| monoatomic ion transport | biological process | The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai] |
| protein localization | biological process | Any process in which a protein is transported to, or maintained in, a specific location. [GOC:ai] |
| epithelial cell differentiation | biological process | The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. [GOC:ecd, PMID:11839751] |
| proton transmembrane transport | biological process | The directed movement of a proton across a membrane. [GO_REF:0000069, GOC:pr, GOC:TermGenie] |
| sodium ion import across plasma membrane | biological process | The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos] |
| potassium ion transmembrane transport | biological process | A process in which a potassium ion is transported from one side of a membrane to the other. [GOC:mah] |
| regulation of intracellular pH | biological process | Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion. [GOC:ai, GOC:dph, GOC:tb] |