Proteins > Geranylgeranyl pyrophosphate synthase
Page last updated: 2024-08-07 23:09:11
Geranylgeranyl pyrophosphate synthase
A geranylgeranyl pyrophosphate synthase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95749]
Synonyms
GGPP synthase;
GGPPSase;
EC 2.5.1.-;
(2E,6E)-farnesyl diphosphate synthase;
Dimethylallyltranstransferase;
2.5.1.1;
Farnesyl diphosphate synthase;
Farnesyltranstransferase;
2.5.1.29;
Geranylgeranyl diphosphate synthase
Research
Bioassay Publications (13)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 8 (61.54) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (13)
Drugs with Inhibition Measurements
Drugs with Other Measurements
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.Journal of medicinal chemistry, , Sep-25, Volume: 51, Issue:18, 2008
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents.Journal of medicinal chemistry, , May-23, Volume: 45, Issue:11, 2002
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.Journal of medicinal chemistry, , Sep-25, Volume: 51, Issue:18, 2008
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents.Journal of medicinal chemistry, , May-23, Volume: 45, Issue:11, 2002
Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth.Antimicrobial agents and chemotherapy, , Volume: 54, Issue:7, 2010
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.Journal of medicinal chemistry, , Sep-25, Volume: 51, Issue:18, 2008
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents.Journal of medicinal chemistry, , May-23, Volume: 45, Issue:11, 2002
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.Journal of medicinal chemistry, , Sep-25, Volume: 51, Issue:18, 2008
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents.Journal of medicinal chemistry, , May-23, Volume: 45, Issue:11, 2002
Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis.Journal of medicinal chemistry, , 03-14, Volume: 62, Issue:5, 2019
Fluorescent Farnesyl Diphosphate Analogue: A Probe To Validate trans-Prenyltransferase Inhibitors.Biochemistry, , Aug-09, Volume: 55, Issue:31, 2016
Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.Journal of medicinal chemistry, , Sep-25, Volume: 51, Issue:18, 2008
Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors.Bioorganic & medicinal chemistry, , Jan-01, Volume: 16, Issue:1, 2008
Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases.Proceedings of the National Academy of Sciences of the United States of America, , Jun-12, Volume: 104, Issue:24, 2007
Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid.Journal of medicinal chemistry, , May-13, Volume: 53, Issue:9, 2010
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.Journal of medicinal chemistry, , Sep-25, Volume: 51, Issue:18, 2008
Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases.Proceedings of the National Academy of Sciences of the United States of America, , Jun-12, Volume: 104, Issue:24, 2007
Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors.Journal of medicinal chemistry, , Aug-09, Volume: 61, Issue:15, 2018
Geranyl and neryl triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase.Bioorganic & medicinal chemistry, , May-01, Volume: 22, Issue:9, 2014
Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors.Bioorganic & medicinal chemistry, , Jan-01, Volume: 16, Issue:1, 2008
Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.Journal of medicinal chemistry, , Sep-25, Volume: 51, Issue:18, 2008
Enables
This protein enables 7 target(s):
| Target | Category | Definition |
|---|
| dimethylallyltranstransferase activity | molecular function | Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. [EC:2.5.1.1] |
| farnesyltranstransferase activity | molecular function | Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate. [EC:2.5.1.29, RHEA:17653] |
| geranyltranstransferase activity | molecular function | Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate. [EC:2.5.1.10, RHEA:19361] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| prenyltransferase activity | molecular function | Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). [GOC:mah] |
Located In
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| Z disc | cellular component | Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. [GOC:mtg_muscle, ISBN:0815316194] |
| perinuclear region of cytoplasm | cellular component | Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid] |
Involved In
This protein is involved in 5 target(s):
| Target | Category | Definition |
|---|
| isoprenoid metabolic process | biological process | The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. [ISBN:0198547684] |
| geranyl diphosphate biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of geranyl diphosphate. [GOC:mah, MetaCyc:PWY-5122] |
| geranylgeranyl diphosphate biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of geranylgeranyl diphosphate. [GOC:mah, MetaCyc:PWY-5120] |
| farnesyl diphosphate biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of farnesyl diphosphate. [GOC:jl] |
| isoprenoid biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. [ISBN:0198506732] |