Page last updated: 2024-08-07 23:09:11
Geranylgeranyl pyrophosphate synthase
A geranylgeranyl pyrophosphate synthase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95749]
Synonyms
GGPP synthase;
GGPPSase;
EC 2.5.1.-;
(2E,6E)-farnesyl diphosphate synthase;
Dimethylallyltranstransferase;
2.5.1.1;
Farnesyl diphosphate synthase;
Farnesyltranstransferase;
2.5.1.29;
Geranylgeranyl diphosphate synthase
Research
Bioassay Publications (13)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 8 (61.54) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (13)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| alendronate | Homo sapiens (human) | IC50 | 427.7868 | 3 | 4 |
| pamidronate | Homo sapiens (human) | IC50 | 185.8665 | 3 | 4 |
| risedronic acid | Homo sapiens (human) | IC50 | 75,195.2825 | 4 | 4 |
| risedronic acid | Homo sapiens (human) | Ki | 8,300.0000 | 1 | 1 |
| ibandronic acid | Homo sapiens (human) | IC50 | 80.3232 | 3 | 4 |
| zoledronic acid | Homo sapiens (human) | IC50 | 72.5413 | 7 | 11 |
| zoledronic acid | Homo sapiens (human) | Ki | 2.7000 | 1 | 1 |
| 6-amino-1-hydroxyhexane-1,1-diphosphonate | Homo sapiens (human) | IC50 | 690.0000 | 1 | 1 |
| ne 58051 | Homo sapiens (human) | IC50 | 410.0000 | 1 | 1 |
| ym 529 | Homo sapiens (human) | IC50 | 75.9940 | 4 | 5 |
| ym 529 | Homo sapiens (human) | Ki | 1.8000 | 1 | 1 |
| 1-hydroxypentane-1,1-bisphosphonate | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| 1,1-hydroxyoctanodiphosphonate | Homo sapiens (human) | IC50 | 4.3000 | 1 | 1 |
| sq 109 | Homo sapiens (human) | IC50 | 4.5000 | 1 | 1 |
| digeranyl bisphosphonate | Homo sapiens (human) | IC50 | 0.5544 | 8 | 9 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| zoledronic acid | Homo sapiens (human) | Activity | 100.0000 | 1 | 1 |
| farnesyl pyrophosphate | Homo sapiens (human) | Km | 0.7100 | 1 | 1 |
| digeranyl bisphosphonate | Homo sapiens (human) | Activity | 25.0000 | 1 | 1 |
Enables
This protein enables 7 target(s):
| Target | Category | Definition |
|---|---|---|
| dimethylallyltranstransferase activity | molecular function | Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. [EC:2.5.1.1] |
| farnesyltranstransferase activity | molecular function | Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate. [EC:2.5.1.29, RHEA:17653] |
| geranyltranstransferase activity | molecular function | Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate. [EC:2.5.1.10, RHEA:19361] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| prenyltransferase activity | molecular function | Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). [GOC:mah] |
Located In
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| Z disc | cellular component | Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. [GOC:mtg_muscle, ISBN:0815316194] |
| perinuclear region of cytoplasm | cellular component | Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid] |
Involved In
This protein is involved in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| isoprenoid metabolic process | biological process | The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. [ISBN:0198547684] |
| geranyl diphosphate biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of geranyl diphosphate. [GOC:mah, MetaCyc:PWY-5122] |
| geranylgeranyl diphosphate biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of geranylgeranyl diphosphate. [GOC:mah, MetaCyc:PWY-5120] |
| farnesyl diphosphate biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of farnesyl diphosphate. [GOC:jl] |
| isoprenoid biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. [ISBN:0198506732] |