G protein-activated inward rectifier potassium channel 2

A G protein-activated inward rectifier potassium channel 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48051]

GIRK-2;
BIR1;
Inward rectifier K(+) channel Kir3.2;
KATP-2;
Potassium channel, inwardly rectifying subfamily J member 6

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
naringin	Homo sapiens (human)	EC50	100.0000	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)
1-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]-3-[1,1,1-trifluoro-2-(trifluoromethyl)butan-2-yl]urea	Homo sapiens (human)	POTENCY_uM	30.0000	1
1-(3-chlorophenyl)-3-(2-phenoxyphenyl)thiourea	Homo sapiens (human)	POTENCY_uM	8.0911	1
3-bromo-4-methoxy-N-[(propan-2-ylamino)-sulfanylidenemethyl]benzamide	Homo sapiens (human)	POTENCY_uM	2.2518	1
1-(4-butylphenyl)-3-[4-chloro-3-(dimethylsulfamoyl)phenyl]thiourea	Homo sapiens (human)	POTENCY_uM	4.0003	1
1-(4-chlorophenyl)-3-[2-(2-furanylmethyl)cyclohexyl]urea	Homo sapiens (human)	POTENCY_uM	4.1435	1

This protein enables 3 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
G-protein activated inward rectifier potassium channel activity	molecular function	Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. [GOC:cb, GOC:mah]
inward rectifier potassium channel activity	molecular function	Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. [GOC:cb, GOC:mah, PMID:14977398]

This protein is located in 2 target(s):

Target	Category	Definition
Golgi apparatus	cellular component	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is part of 1 target(s):

Target	Category	Definition
voltage-gated potassium channel complex	cellular component	A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. [GOC:mah]

This protein is involved in 3 target(s):

Target	Category	Definition
potassium ion transport	biological process	The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
regulation of monoatomic ion transmembrane transport	biological process	Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. [GOC:mah]
potassium ion import across plasma membrane	biological process	The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol. [PMID:9139127]