Page last updated: 2024-08-07 17:18:52
Beta-2 adrenergic receptor
A beta-2 adrenergic receptor that is encoded in the genome of guinea pig. [OMA:Q8K4Z4, PRO:DNx]
Synonyms
Beta-2 adrenoreceptor;
Beta-2 adrenoceptor
Research
Bioassay Publications (34)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 12 (35.29) | 18.7374 |
| 1990's | 3 (8.82) | 18.2507 |
| 2000's | 6 (17.65) | 29.6817 |
| 2010's | 13 (38.24) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (39)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| albuterol | Cavia porcellus (domestic guinea pig) | Ki | 1.8280 | 1 | 1 |
| amphetamine | Cavia porcellus (domestic guinea pig) | IC50 | 0.9600 | 1 | 1 |
| berotek | Cavia porcellus (domestic guinea pig) | IC50 | 0.0600 | 1 | 1 |
| fluoxetine | Cavia porcellus (domestic guinea pig) | IC50 | 0.0094 | 1 | 1 |
| formoterol fumarate | Cavia porcellus (domestic guinea pig) | IC50 | 0.0004 | 1 | 1 |
| formoterol fumarate | Cavia porcellus (domestic guinea pig) | Ki | 0.6833 | 3 | 3 |
| propranolol | Cavia porcellus (domestic guinea pig) | IC50 | 0.0288 | 1 | 1 |
| salmeterol xinafoate | Cavia porcellus (domestic guinea pig) | IC50 | 0.0035 | 1 | 1 |
| salmeterol xinafoate | Cavia porcellus (domestic guinea pig) | Ki | 0.8383 | 3 | 3 |
| venlafaxine | Cavia porcellus (domestic guinea pig) | IC50 | 0.0270 | 1 | 1 |
| dichloroisoproterenol | Cavia porcellus (domestic guinea pig) | IC50 | 0.9772 | 1 | 1 |
| ethyl acetate | Cavia porcellus (domestic guinea pig) | IC50 | 10.0000 | 1 | 1 |
| duloxetine | Cavia porcellus (domestic guinea pig) | IC50 | 0.0030 | 1 | 1 |
| carmoterol | Cavia porcellus (domestic guinea pig) | Ki | 0.0032 | 1 | 1 |
| divaplon | Cavia porcellus (domestic guinea pig) | IC50 | 0.0560 | 1 | 1 |
| cilomilast | Cavia porcellus (domestic guinea pig) | IC50 | 0.1200 | 1 | 1 |
| sibenadet | Cavia porcellus (domestic guinea pig) | Ki | 0.0040 | 1 | 1 |
| darifenacin | Cavia porcellus (domestic guinea pig) | Ki | 0.0159 | 1 | 1 |
| rolipram | Cavia porcellus (domestic guinea pig) | IC50 | 0.5000 | 1 | 1 |
| roflumilast | Cavia porcellus (domestic guinea pig) | IC50 | 0.0010 | 1 | 1 |
| nalorphine | Cavia porcellus (domestic guinea pig) | IC50 | 0.0060 | 1 | 1 |
| naloxone | Cavia porcellus (domestic guinea pig) | IC50 | 0.0055 | 1 | 1 |
| morphine | Cavia porcellus (domestic guinea pig) | IC50 | 0.2500 | 1 | 1 |
| indacaterol | Cavia porcellus (domestic guinea pig) | IC50 | 0.0079 | 1 | 1 |
| indacaterol | Cavia porcellus (domestic guinea pig) | Ki | 0.0760 | 1 | 1 |
| amg 487 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0080 | 1 | 1 |
Drugs with Activation Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| nifedipine | Cavia porcellus (domestic guinea pig) | ID50 | 0.0100 | 1 | 1 |
| propranolol | Cavia porcellus (domestic guinea pig) | Affinity constant | 0.0006 | 1 | 1 |
Insights on the role of boron containing moieties in the design of new potent and efficient agonists targeting the β2 adrenoceptor.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 25, Issue:4, 2015
The identification of indacaterol as an ultralong-acting inhaled beta2-adrenoceptor agonist.Journal of medicinal chemistry, , May-13, Volume: 53, Issue:9, 2010
Synthesis, pharmacological and in silico evaluation of 1-(4-di-hydroxy-3,5-dioxa-4-borabicyclo[4.4.0]deca-7,9,11-trien-9-yl)-2-(tert-butylamino)ethanol, a compound designed to act as a beta2 adrenoceptor agonist.European journal of medicinal chemistry, , Volume: 44, Issue:7, 2009
Synthesis and pharmacological characterization of beta2-adrenergic agonist enantiomers: zilpaterol.Journal of medicinal chemistry, , Mar-26, Volume: 52, Issue:6, 2009
Nitric oxide donor beta2-agonists: furoxan derivatives containing the fenoterol moiety and related furazans.Journal of medicinal chemistry, , Oct-04, Volume: 50, Issue:20, 2007
Synthesis and preliminary evaluation of (R,R)(S,S) 5-(2-(2-[4-(2-[(18)F]fluoroethoxy)phenyl]-1-methylethylamino)-1-hydroxyethyl)-benzene-1,3-diol ([(18)F]FEFE) for the in vivo visualisation and quantification of the beta2-adrenergic receptor status in lunBioorganic & medicinal chemistry letters, , Aug-18, Volume: 13, Issue:16, 2003
The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting β2-adrenoceptor agonist.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 24, Issue:17, 2014
Multivalent design of long-acting β(2)-adrenoceptor agonists incorporating biarylamines.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 24, Issue:12, 2014
The discovery of long-acting saligenin β₂ adrenergic receptor agonists incorporating hydantoin or uracil rings.Bioorganic & medicinal chemistry, , Jul-15, Volume: 19, Issue:14, 2011
The identification of indacaterol as an ultralong-acting inhaled beta2-adrenoceptor agonist.Journal of medicinal chemistry, , May-13, Volume: 53, Issue:9, 2010
[no title available]Journal of natural products, , 11-22, Volume: 82, Issue:11, 2019
[no title available]Bioorganic & medicinal chemistry, , 06-15, Volume: 27, Issue:12, 2019
Insights on the role of boron containing moieties in the design of new potent and efficient agonists targeting the β2 adrenoceptor.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 25, Issue:4, 2015
The discovery of long-acting saligenin β₂ adrenergic receptor agonists incorporating a urea group.Bioorganic & medicinal chemistry, , Oct-15, Volume: 19, Issue:20, 2011
Synthesis and evaluation of potent and selective beta(3) adrenergic receptor agonists containing acylsulfonamide, sulfonylsulfonamide, and sulfonylurea carboxylic acid isosteres.Journal of medicinal chemistry, , Jan-31, Volume: 45, Issue:3, 2002
Beta 1-selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted amino)-2-hydroxypropoxy]phenyl]imidazole class. 2.Journal of medicinal chemistry, , Volume: 29, Issue:6, 1986
Beta 1-selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazole class.Journal of medicinal chemistry, , Volume: 26, Issue:7, 1983
Use of (S)-(trifloxymethyl)oxirane in the synthesis of a chiral beta-adrenoceptor antagonist, (R)- and (S)-9-[[3-(tert-butylamino)-2-hydroxypropyl]oximino]fluorene.Journal of medicinal chemistry, , Volume: 25, Issue:8, 1982
Design, synthesis and cardiovascular evaluation of some aminoisopropanoloxy derivatives of xanthone.Bioorganic & medicinal chemistry, , 07-30, Volume: 26, Issue:13, 2018
Conformationally restrained analogs of sympathomimetic catecholamines. Synthesis, conformational analysis, and adrenergic activity of isochroman derivatives.Journal of medicinal chemistry, , Oct-15, Volume: 36, Issue:21, 1993
Beta 1-selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted amino)-2-hydroxypropoxy]phenyl]imidazole class. 2.Journal of medicinal chemistry, , Volume: 29, Issue:6, 1986
New chiral and isomeric cyclopropyl ketoxime propanolamine derivatives with potent beta-adrenergic blocking properties.Journal of medicinal chemistry, , Volume: 28, Issue:7, 1985
Beta 1-selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazole class.Journal of medicinal chemistry, , Volume: 26, Issue:7, 1983
beta 1-selective adrenoceptor antagonists. 1. Synthesis and beta-adrenergic blocking activity of a series of binary (aryloxy)propanolamines.Journal of medicinal chemistry, , Volume: 26, Issue:11, 1983
Synthesis and preliminary biological studies of 4- and 5-[2-hydroxy-3-(isopropylamino)propoxy]benzimidazoles: selective beta2 adrenergic blocking agents.Journal of medicinal chemistry, , Volume: 22, Issue:2, 1979
[no title available]Bioorganic & medicinal chemistry, , 06-15, Volume: 27, Issue:12, 2019
Multivalent design of long-acting β(2)-adrenoceptor agonists incorporating biarylamines.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 24, Issue:12, 2014
The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting β2-adrenoceptor agonist.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 24, Issue:17, 2014
The discovery of long-acting saligenin β₂ adrenergic receptor agonists incorporating hydantoin or uracil rings.Bioorganic & medicinal chemistry, , Jul-15, Volume: 19, Issue:14, 2011
The discovery of long-acting saligenin β₂ adrenergic receptor agonists incorporating a urea group.Bioorganic & medicinal chemistry, , Oct-15, Volume: 19, Issue:20, 2011
The identification of indacaterol as an ultralong-acting inhaled beta2-adrenoceptor agonist.Journal of medicinal chemistry, , May-13, Volume: 53, Issue:9, 2010
The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting β2-adrenoceptor agonist.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 24, Issue:17, 2014
The identification of indacaterol as an ultralong-acting inhaled beta2-adrenoceptor agonist.Journal of medicinal chemistry, , May-13, Volume: 53, Issue:9, 2010