Proteins > Folylpolyglutamate synthase, mitochondrial
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Folylpolyglutamate synthase, mitochondrial
A folylpolyglutamate synthase, mitochondrial that is encoded in the genome of mouse. [OMA:P48760, PRO:DNx]
Synonyms
EC 6.3.2.17;
Folylpoly-gamma-glutamate synthetase;
FPGS;
Tetrahydrofolylpolyglutamate synthase;
Tetrahydrofolate synthase
Research
Bioassay Publications (4)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (4)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| methotrexate | Mus musculus (house mouse) | Ki | 166.0000 | 1 | 1 |
| aminopterin | Mus musculus (house mouse) | Ki | 17.6000 | 1 | 1 |
Drugs with Other Measurements
(6R,6S)-5,8,10-trideaza-5,6,7,8-tetrahydrofolate and 6(R,6S)-5,8,10-trideaza-5,6,7,8-tetrahydropteroyl-L-ornithine as potential antifolates and antitumor agents.Journal of medicinal chemistry, , Volume: 32, Issue:3, 1989
Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain.Journal of medicinal chemistry, , Volume: 29, Issue:5, 1986
A mechanism for the addition of multiple moles of glutamate by folylpolyglutamate synthetase.Journal of medicinal chemistry, , Volume: 27, Issue:10, 1984
(6R,6S)-5,8,10-trideaza-5,6,7,8-tetrahydrofolate and 6(R,6S)-5,8,10-trideaza-5,6,7,8-tetrahydropteroyl-L-ornithine as potential antifolates and antitumor agents.Journal of medicinal chemistry, , Volume: 32, Issue:3, 1989
Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain.Journal of medicinal chemistry, , Volume: 29, Issue:5, 1986
Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin.Journal of medicinal chemistry, , Volume: 28, Issue:7, 1985
(6R,6S)-5,8,10-trideaza-5,6,7,8-tetrahydrofolate and 6(R,6S)-5,8,10-trideaza-5,6,7,8-tetrahydropteroyl-L-ornithine as potential antifolates and antitumor agents.Journal of medicinal chemistry, , Volume: 32, Issue:3, 1989
Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin.Journal of medicinal chemistry, , Volume: 28, Issue:7, 1985