Proteins > L-lactate dehydrogenase B chain
Page last updated: 2024-08-07 12:53:47
L-lactate dehydrogenase B chain
An L-lactate dehydrogenase B chain that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07195]
Synonyms
LDH-B;
EC 1.1.1.27;
LDH heart subunit;
LDH-H;
Renal carcinoma antigen NY-REN-46
Research
Bioassay Publications (8)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
Compounds (10)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| guanidine hydrochloride | Homo sapiens (human) | EC50 | 843,142.8571 | 7 | 7 |
Discovery of human lactate dehydrogenase A (LDHA) inhibitors as anticancer agents to inhibit the proliferation of MG-63 osteosarcoma cells.MedChemComm, , Aug-01, Volume: 8, Issue:8, 2017
Recent Update on Human Lactate Dehydrogenase Enzyme 5 (hLDH5) Inhibitors: A Promising Approach for Cancer Chemotherapy.Journal of medicinal chemistry, , Jan-28, Volume: 59, Issue:2, 2016
Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 24, Issue:16, 2014
Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 23, Issue:11, 2013
Recent Update on Human Lactate Dehydrogenase Enzyme 5 (hLDH5) Inhibitors: A Promising Approach for Cancer Chemotherapy.Journal of medicinal chemistry, , Jan-28, Volume: 59, Issue:2, 2016
Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation.Journal of medicinal chemistry, , Apr-12, Volume: 55, Issue:7, 2012
Selective inhibitors of human lactate dehydrogenases and lactate dehydrogenase from the malarial parasite Plasmodium falciparum.Journal of medicinal chemistry, , Sep-24, Volume: 41, Issue:20, 1998
Enables
This protein enables 5 target(s):
| Target | Category | Definition |
|---|
| L-lactate dehydrogenase activity | molecular function | Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. [EC:1.1.1.27, RHEA:23444] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| kinase binding | molecular function | Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. [GOC:jl] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| NAD binding | molecular function | Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. [GOC:ai] |
Located In
This protein is located in 6 target(s):
| Target | Category | Definition |
|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| mitochondrial inner membrane | cellular component | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| membrane raft | cellular component | Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. [PMID:16645198, PMID:20044567] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|
| oxidoreductase complex | cellular component | Any protein complex that possesses oxidoreductase activity. [GOC:bhm, PMID:18982432] |
Involved In
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|
| lactate metabolic process | biological process | The chemical reactions and pathways involving lactate, the anion of lactic acid. [ISBN:0198547684] |
| pyruvate metabolic process | biological process | The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. [GOC:go_curators] |
| NAD metabolic process | biological process | The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. [GOC:jl, ISBN:0618254153] |