L-lactate dehydrogenase B chain

An L-lactate dehydrogenase B chain that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07195]

LDH-B;
EC 1.1.1.27;
LDH heart subunit;
LDH-H;
Renal carcinoma antigen NY-REN-46

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
oxamic acid	Homo sapiens (human)	IC50	33.8000	2	2
oxamic acid	Homo sapiens (human)	Ki	94.4000	2	2
gossypol	Homo sapiens (human)	Ki	1.4000	1	1
1-hydroxy-2-naphthoic acid	Homo sapiens (human)	IC50	500.0000	1	1
gossylic nitrile-1,1'-diacetate	Homo sapiens (human)	Ki	33.0000	1	1
3-dihydroxy-6-methyl-7-(phenylmethyl)-4-propylnaphthalene-1-carboxylic acid	Homo sapiens (human)	IC50	500.0000	1	1
3-dihydroxy-6-methyl-7-(phenylmethyl)-4-propylnaphthalene-1-carboxylic acid	Homo sapiens (human)	Ki	0.6833	3	3
adenosine monophosphate	Homo sapiens (human)	IC50	500.0000	1	1
galloflavin	Homo sapiens (human)	Ki	15.0600	1	1
gossylic iminolactone	Homo sapiens (human)	Ki	92.0000	1	1
gossylic lactone	Homo sapiens (human)	Ki	0.4000	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
guanidine hydrochloride	Homo sapiens (human)	EC50	843,142.8571	7	7

This protein enables 5 target(s):

Target	Category	Definition
L-lactate dehydrogenase activity	molecular function	Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. [EC:1.1.1.27, RHEA:23444]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
kinase binding	molecular function	Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. [GOC:jl]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
NAD binding	molecular function	Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. [GOC:ai]

This protein is located in 6 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
mitochondrial inner membrane	cellular component	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
membrane raft	cellular component	Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. [PMID:16645198, PMID:20044567]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

This protein is active in 1 target(s):

Target	Category	Definition
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]

This protein is part of 1 target(s):

Target	Category	Definition
oxidoreductase complex	cellular component	Any protein complex that possesses oxidoreductase activity. [GOC:bhm, PMID:18982432]

This protein is involved in 3 target(s):

Target	Category	Definition
lactate metabolic process	biological process	The chemical reactions and pathways involving lactate, the anion of lactic acid. [ISBN:0198547684]
pyruvate metabolic process	biological process	The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. [GOC:go_curators]
NAD metabolic process	biological process	The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. [GOC:jl, ISBN:0618254153]