Proteins > Oxysterols receptor LXR-beta
Page last updated: 2024-08-07 16:51:01

Oxysterols receptor LXR-beta

An oxysterols receptor LXR-beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:P55055]

Synonyms

Liver X receptor beta;
Nuclear receptor NER;
Nuclear receptor subfamily 1 group H member 2;
Ubiquitously-expressed nuclear receptor

Research

Bioassay Publications (58)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's19 (32.76)29.6817
2010's36 (62.07)24.3611
2020's3 (5.17)2.80

Compounds (25)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
4-chlorophenolHomo sapiens (human)Ki169.000011
butylparabenHomo sapiens (human)Ki66.000011
3-chlorophenolHomo sapiens (human)Ki184.000011
4-phenoxyphenolHomo sapiens (human)Ki62.000011
bis(4-oxyphenyl)sulfideHomo sapiens (human)Ki68.000011
1-deoxynojirimycinHomo sapiens (human)IC50150.000023
podocarpic acidHomo sapiens (human)IC5050.000011
2-chloro-1,4-dimethoxybenzeneHomo sapiens (human)Ki476.000011
gw 3965Homo sapiens (human)IC500.4700911
gw 3965Homo sapiens (human)Ki0.002222
t0901317Homo sapiens (human)IC506.32072123
t0901317Homo sapiens (human)Ki0.069155
genisteinHomo sapiens (human)IC5048.000023
pregna-4,17-diene-3,16-dioneHomo sapiens (human)IC50100.000011
3-chloro-4-(3-(7-propyl-3-trifluoromethyl-6-benzisoxazolyl)propylthio)phenylacetic acidHomo sapiens (human)IC500.026422
riccardin cHomo sapiens (human)IC507.700023
way 252623Homo sapiens (human)IC500.075723
way 252623Homo sapiens (human)Ki0.014222
incb-018424Homo sapiens (human)Ki45.000011
sr9238Homo sapiens (human)IC500.071522
sr9238Homo sapiens (human)Ki0.352011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
4-chlorophenolHomo sapiens (human)EC50514.000011
3-chlorophenolHomo sapiens (human)EC50519.000011
4-phenoxyphenolHomo sapiens (human)EC50593.000011
betulinic acidHomo sapiens (human)EC5050.000011
bexaroteneHomo sapiens (human)EC500.434011
podocarpic acidHomo sapiens (human)EC5050.000022
cyanidinHomo sapiens (human)EC50125.200011
cyanidinHomo sapiens (human)Kd73.200011
(22r)-22-hydroxycholesterolHomo sapiens (human)EC5011.583333
2-chloro-1,4-dimethoxybenzeneHomo sapiens (human)EC501,028.000011
gw 3965Homo sapiens (human)EC500.14432427
t0901317Homo sapiens (human)EC500.12345153
t0901317Homo sapiens (human)Kd0.103011
alitretinoinHomo sapiens (human)EC501.730011
24,25-epoxycholesterolHomo sapiens (human)EC505.213544
pregna-4,17-diene-3,16-dioneHomo sapiens (human)EC503.600011
acanthoic acidHomo sapiens (human)EC5050.000011
3-chloro-4-(3-(7-propyl-3-trifluoromethyl-6-benzisoxazolyl)propylthio)phenylacetic acidHomo sapiens (human)EC501.685645
bms 687453Homo sapiens (human)EC5025.000011
way 252623Homo sapiens (human)EC502.060144

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
betulinic acidHomo sapiens (human)LC5025.000011
podocarpic acidHomo sapiens (human)LC5050.000011
acanthoic acidHomo sapiens (human)LC501.490011
3-chloro-4-(3-(7-propyl-3-trifluoromethyl-6-benzisoxazolyl)propylthio)phenylacetic acidHomo sapiens (human)LC500.025011

Enables

This protein enables 11 target(s):

TargetCategoryDefinition
RNA polymerase II cis-regulatory region sequence-specific DNA bindingmolecular functionBinding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018]
DNA-binding transcription factor activity, RNA polymerase II-specificmolecular functionA DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018]
DNA-binding transcription activator activity, RNA polymerase II-specificmolecular functionA DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859]
DNA bindingmolecular functionAny molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
zinc ion bindingmolecular functionBinding to a zinc ion (Zn). [GOC:ai]
chromatin DNA bindingmolecular functionBinding to DNA that is assembled into chromatin. [GOC:mah]
apolipoprotein A-I receptor bindingmolecular functionBinding to an apolipoprotein A-I receptor. [GOC:BHF, GOC:rl]
nuclear retinoid X receptor bindingmolecular functionBinding to a nuclear retinoid X receptor. [GOC:ai]
ATPase bindingmolecular functionBinding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. [GOC:ai]
nuclear receptor activitymolecular functionA DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus. [GOC:txnOH-2018, PMID:23457262]

Located In

This protein is located in 4 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 2 target(s):

TargetCategoryDefinition
RNA polymerase II transcription regulator complexcellular componentA transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. [GOC:tb]
chromatincellular componentThe ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]

Involved In

This protein is involved in 29 target(s):

TargetCategoryDefinition
hormone-mediated signaling pathwaybiological processThe series of molecular signals mediated by the detection of a hormone. [GOC:sm]
negative regulation of macrophage derived foam cell differentiationbiological processAny process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. [GOC:add, GOC:BHF, GOC:dph, GOC:tb]
positive regulation of triglyceride biosynthetic processbiological processAny process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. [GOC:BHF, GOC:tb]
positive regulation of cholesterol effluxbiological processAny process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. [GOC:BHF, GOC:dph, GOC:tb]
positive regulation of lipid storagebiological processAny process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. [GOC:BHF, GOC:dph, GOC:tb]
negative regulation of cholesterol storagebiological processAny process that decreases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:BHF, GOC:dph, GOC:tb]
intracellular receptor signaling pathwaybiological processThe series of molecular signals initiated by a ligand binding to a receptor located within a cell. [GOC:bf, GOC:mah]
negative regulation of lipid transportbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]
positive regulation of cholesterol transportbiological processAny process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]
phosphatidylcholine acyl-chain remodelingbiological processRemodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains. [GOC:mw, PMID:18195019, PMID:18458083]
cholesterol homeostasisbiological processAny process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. [GOC:go_curators]
mRNA transcription by RNA polymerase IIbiological processThe cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. [GOC:jl, ISBN:0321000382]
positive regulation of fatty acid biosynthetic processbiological processAny process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids. [GOC:go_curators]
negative regulation of proteolysisbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. [GOC:go_curators]
negative regulation of DNA-templated transcriptionbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
positive regulation of DNA-templated transcriptionbiological processAny process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
positive regulation of transcription by RNA polymerase IIbiological processAny process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
negative regulation of pinocytosisbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes. [GOC:go_curators]
positive regulation of lipoprotein lipase activitybiological processAny process that activates or increases the activity of the enzyme lipoprotein lipase. [GOC:ai]
positive regulation of protein metabolic processbiological processAny process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. [GOC:ai]
negative regulation of type II interferon-mediated signaling pathwaybiological processAny process that decreases the rate, frequency or extent of an interferon-gamma-mediated signaling pathway. [GOC:dph]
positive regulation of high-density lipoprotein particle assemblybiological processAny process that increases the frequency, rate, or extent of high-density lipoprotein particle assembly. High-density lipoprotein particle assembly is the aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle. [GOC:BHF, GOC:dph, GOC:tb]
positive regulation of pancreatic juice secretionbiological processAny process that increases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. [GOC:BHF, GOC:dph, GOC:tb]
positive regulation of secretion of lysosomal enzymesbiological processAny process that increases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell. [GOC:BHF]
negative regulation of cold-induced thermogenesisbiological processAny process that stops, prevents, or reduces the rate of cold-induced thermogenesis. [PMID:27876809]
positive regulation of miRNA transcriptionbiological processAny process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription. [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545]
negative regulation of response to endoplasmic reticulum stressbiological processAny process that stops, prevents or reduces the frequency, rate or extent of a response to endoplasmic reticulum stress. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11381086]
cell differentiationbiological processThe cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732]
negative regulation of transcription by RNA polymerase IIbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]