Death-associated protein kinase 1

A death-associated protein kinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P53355]

Synonyms

DAP kinase 1;
EC 2.7.11.1

Research

Bioassay Publications (13)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (23.08)	29.6817
2010's	10 (76.92)	24.3611
2020's	0 (0.00)	2.80

Compounds (92)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
catechin	Homo sapiens (human)	IC50	300.0000	1	1
staurosporine	Homo sapiens (human)	IC50	0.0101	6	6
epicatechin gallate	Homo sapiens (human)	IC50	300.0000	1	1
cyanidin	Homo sapiens (human)	IC50	150.0000	1	1
birb 796	Homo sapiens (human)	IC50	30.0000	1	1
pelargonidin	Homo sapiens (human)	IC50	220.0000	1	1
quercetin	Homo sapiens (human)	IC50	8.9000	1	1
apigenin	Homo sapiens (human)	IC50	31.0000	1	1
luteolin	Homo sapiens (human)	IC50	21.0000	1	1
gossypetin	Homo sapiens (human)	IC50	87.0000	1	1
kaempferol	Homo sapiens (human)	IC50	10.0000	1	1
genistein	Homo sapiens (human)	IC50	98.0000	1	1
sulfuretin	Homo sapiens (human)	IC50	13.1500	1	1
baicalein	Homo sapiens (human)	IC50	120.0000	1	1
chrysin	Homo sapiens (human)	IC50	300.0000	1	1
morin	Homo sapiens (human)	IC50	6.3000	2	2
myricetin	Homo sapiens (human)	IC50	23.0000	1	1
3',4',7-trihydroxyisoflavone	Homo sapiens (human)	IC50	280.0000	1	1
nutlin-3a	Homo sapiens (human)	IC50	25.0000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
sb 202190	Homo sapiens (human)	Kd	10.0000	1	1
imatinib	Homo sapiens (human)	Kd	10.0000	2	2
staurosporine	Homo sapiens (human)	Kd	0.0014	2	2
gefitinib	Homo sapiens (human)	Kd	10.0000	2	2
lestaurtinib	Homo sapiens (human)	Kd	0.0800	2	2
vatalanib	Homo sapiens (human)	Kd	10.0000	2	2
ruboxistaurin	Homo sapiens (human)	Kd	0.9700	2	2
canertinib	Homo sapiens (human)	Kd	10.0000	2	2
birb 796	Homo sapiens (human)	Kd	10.0000	2	2
cyc 202	Homo sapiens (human)	Kd	10.0000	1	1
sb 203580	Homo sapiens (human)	Kd	10.0000	2	2
enzastaurin	Homo sapiens (human)	Kd	10.0000	1	1
erlotinib	Homo sapiens (human)	Kd	10.0000	2	2
lapatinib	Homo sapiens (human)	Kd	10.0000	2	2
sorafenib	Homo sapiens (human)	Kd	10.0000	3	3
pd 173955	Homo sapiens (human)	Kd	10.0000	1	1
s 1033	Homo sapiens (human)	Kd	10.0000	1	1
bms 387032	Homo sapiens (human)	Kd	10.0000	2	2
tandutinib	Homo sapiens (human)	Kd	10.0000	3	3
vx-745	Homo sapiens (human)	Kd	10.0000	2	2
dasatinib	Homo sapiens (human)	Kd	10.0000	2	2
zd 6474	Homo sapiens (human)	Kd	10.0000	2	2
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide	Homo sapiens (human)	Kd	10.0000	1	1
alvocidib	Homo sapiens (human)	Kd	10.0000	2	2
bosutinib	Homo sapiens (human)	Kd	10.0000	1	1
su 11248	Homo sapiens (human)	Kd	0.1200	3	3
jnj-7706621	Homo sapiens (human)	Kd	10.0000	1	1
vx680	Homo sapiens (human)	Kd	10.0000	2	2
ekb 569	Homo sapiens (human)	Kd	10.0000	1	1
axitinib	Homo sapiens (human)	Kd	10.0000	1	1
pd 184352	Homo sapiens (human)	Kd	10.0000	1	1
bms345541	Homo sapiens (human)	Kd	10.0000	1	1
midostaurin	Homo sapiens (human)	Kd	4.7000	3	3
ki 20227	Homo sapiens (human)	Kd	10.0000	1	1
cp 724714	Homo sapiens (human)	Kd	10.0000	1	1
pi103	Homo sapiens (human)	Kd	2.4000	2	2
hki 272	Homo sapiens (human)	Kd	10.0000	1	1
tofacitinib	Homo sapiens (human)	Kd	10.0000	2	2
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamide	Homo sapiens (human)	Kd	10.0000	1	1
cediranib	Homo sapiens (human)	Kd	10.0000	1	1
masitinib	Homo sapiens (human)	Kd	10.0000	1	1
pazopanib	Homo sapiens (human)	Kd	10.0000	2	2
azd 6244	Homo sapiens (human)	Kd	10.0000	1	1
su 14813	Homo sapiens (human)	Kd	0.2700	2	2
bibw 2992	Homo sapiens (human)	Kd	10.0000	1	1
tg100-115	Homo sapiens (human)	Kd	10.0000	1	1
pha 665752	Homo sapiens (human)	Kd	10.0000	1	1
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one	Homo sapiens (human)	Kd	0.0550	1	1
brivanib	Homo sapiens (human)	Kd	10.0000	1	1
at 7519	Homo sapiens (human)	Kd	10.0000	1	1
bi 2536	Homo sapiens (human)	Kd	0.5400	1	1
nvp-ast487	Homo sapiens (human)	Kd	10.0000	2	2
kw 2449	Homo sapiens (human)	Kd	0.3600	1	1
abt 869	Homo sapiens (human)	Kd	10.0000	2	2
gw 2580	Homo sapiens (human)	Kd	10.0000	2	2
crizotinib	Homo sapiens (human)	Kd	10.0000	1	1
chir-265	Homo sapiens (human)	Kd	10.0000	2	2
motesanib	Homo sapiens (human)	Kd	10.0000	2	2
mln8054	Homo sapiens (human)	Kd	10.0000	2	2
GDC-0879	Homo sapiens (human)	Kd	10.0000	1	1
gsk 461364	Homo sapiens (human)	Kd	1.4000	1	1
azd 1152-hqpa	Homo sapiens (human)	Kd	10.0000	2	2
nvp-tae684	Homo sapiens (human)	Kd	1.8000	1	1
fedratinib	Homo sapiens (human)	Kd	0.0160	1	1
gsk690693	Homo sapiens (human)	Kd	3.0000	1	1
gdc 0941	Homo sapiens (human)	Kd	4.0000	1	1
plx 4720	Homo sapiens (human)	Kd	10.0000	1	1
sgx 523	Homo sapiens (human)	Kd	10.0000	1	1
quizartinib	Homo sapiens (human)	Kd	10.0000	2	2
incb-018424	Homo sapiens (human)	Kd	0.0720	1	1
gsk 1838705a	Homo sapiens (human)	Kd	0.6200	1	1
gsk 1363089	Homo sapiens (human)	Kd	10.0000	1	1
chir 258	Homo sapiens (human)	Kd	10.0000	2	2
nintedanib	Homo sapiens (human)	Kd	10.0000	1	1
pp242	Homo sapiens (human)	Kd	0.0970	1	1

Enables

This protein enables 10 target(s):

Target	Category	Definition
protein kinase activity	molecular function	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. [PMID:25399640]
protein serine/threonine kinase activity	molecular function	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]
calmodulin-dependent protein kinase activity	molecular function	Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. [GOC:mah, PMID:11264466]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
calmodulin binding	molecular function	Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. [GOC:krc]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
GTP binding	molecular function	Binding to GTP, guanosine triphosphate. [GOC:ai]
syntaxin-1 binding	molecular function	Binding to a syntaxin-1 SNAP receptor. [GOC:ai]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
protein serine kinase activity	molecular function	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989]

Located In

This protein is located in 5 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
postsynaptic density	cellular component	An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]
actin cytoskeleton	cellular component	The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. [GOC:jl, ISBN:0395825172, ISBN:0815316194]
glutamatergic synapse	cellular component	A synapse that uses glutamate as a neurotransmitter. [GOC:dos]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
DAPK1-calmodulin complex	cellular component	A serine/threonine protein kinase complex involved in cell survival, apoptosis and autophagic cell death pathways. DAPK1 is activated by the dephosphorylation of a n-terminal serine and calcium-calmodulin binding. [GOC:bhm, PMID:20103772]

Involved In

This protein is involved in 19 target(s):

Target	Category	Definition
defense response to tumor cell	biological process	Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism. [GOC:add, ISBN:0781735149, PMID:16730260]
regulation of response to tumor cell	biological process	Any process that modulates the frequency, rate, or extent of a response to tumor cell. [GOC:add]
protein phosphorylation	biological process	The process of introducing a phosphate group on to a protein. [GOC:hb]
apoptotic process	biological process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
extrinsic apoptotic signaling pathway via death domain receptors	biological process	The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered. [GOC:mah, GOC:mtg_apoptosis]
regulation of autophagy	biological process	Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. [GOC:dph, GOC:tb]
positive regulation of autophagy	biological process	Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. [GOC:dph, GOC:tb]
negative regulation of translation	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. [GOC:isa_complete]
intracellular signal transduction	biological process	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
regulation of apoptotic process	biological process	Any process that modulates the occurrence or rate of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
positive regulation of apoptotic process	biological process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
negative regulation of apoptotic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	biological process	Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
protein autophosphorylation	biological process	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). [ISBN:0198506732]
cellular response to type II interferon	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far. [GOC:mah]
cellular response to hydroperoxide	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH. [GOC:mah]
apoptotic signaling pathway	biological process	The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. [GOC:mtg_apoptosis]
positive regulation of autophagic cell death	biological process	Any process that activates or increases the frequency, rate or extent of autophagic cell death. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25736836]
regulation of NMDA receptor activity	biological process	Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity. [GOC:BHF]