S-pentachlorobuta-1,3-dien-yl-cysteine: nephrotoxic; structure given in first source [MeSH]
| Synonym |
|---|
| s-pentachlorobuta-1,3-dien-yl-cysteine |
| ccris 2171 |
| l-cysteine, s-(1,2,3,4,4-pentachloro-1,3-butadienyl)- |
| s-(1,2,3,4,4-pentachloro-1,3-butadienyl)-l-cysteine |
| (2r)-2-amino-3-[(1e)-1,2,3,4,4-pentachlorobuta-1,3-dienyl]sulfanylpropanoic acid |
| 5-(1,2,3,4,4-pentachloro-1,3-butadienyl)-l-cysteine |
| 87619-82-7 |
| s-pentachlorobutadienyl-l-cysteine |
| (s-pentachlorobutadienyl)-l-cysteine |
| s-(1,2,3,4,4-pentachloro-1,3- butadienyl)-l-cysteine |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|
| aminooxyacetic acid | | amino acid;
hydroxylamines;
monocarboxylic acid | anticonvulsant;
EC 2.6.1.19 (4-aminobutyrate--2-oxoglutarate transaminase) inhibitor;
EC 4.2.1.22 (cystathionine beta-synthase) inhibitor;
nootropic agent | 1987 | 2002 | 31.5 | low | 0 | 1 | 2 | 1 | 0 | 0 |
| pyridoxal | | hydroxymethylpyridine;
methylpyridines;
monohydroxypyridine;
pyridinecarbaldehyde;
vitamin B6 | cofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| urea | | isourea;
monocarboxylic acid amide;
one-carbon compound | Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| p-aminohippuric acid | | N-acylglycine | Daphnia magna metabolite | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| anethole trithione | | methoxybenzenes | | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| egtazic acid | | diether;
tertiary amino compound;
tetracarboxylic acid | chelator | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| hexachlorobutadiene | | organochlorine compound | | 1986 | 1996 | 34.8 | medium | 0 | 4 | 2 | 0 | 0 | 0 |
| acetylcysteine | | acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid | antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary | 1986 | 1997 | 32.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| manganese | | elemental manganese;
manganese group element atom | Escherichia coli metabolite;
micronutrient | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| fura-2 | | | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| homocysteine | | amino acid zwitterion;
homocysteine;
serine family amino acid | fundamental metabolite;
mouse metabolite | 1990 | 2002 | 28.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| s-(1,1,2,2-tetrafluoroethyl)cysteine | | | | 1990 | 1990 | 34.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| fura-2-am | | | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| s-(2-chloro-1,1,2-trifluoroethyl)cysteine | | | | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| s-(1,2,3-trichlorovinyl)cysteine | | | | 1997 | 1997 | 27.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| tretinoin | | retinoic acid;
vitamin A | anti-inflammatory agent;
antineoplastic agent;
antioxidant;
AP-1 antagonist;
human metabolite;
keratolytic drug;
retinoic acid receptor agonist;
retinoid X receptor agonist;
signalling molecule | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| tacrolimus | | macrolide lactam | bacterial metabolite;
immunosuppressive agent | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| s-(1,2,3,4,4-pentachloro-1,3-butadienyl)glutathione | | | | 1986 | 1990 | 36.0 | high | 0 | 1 | 1 | 0 | 0 | 0 |
| sulfur | | chalcogen;
nonmetal atom | macronutrient | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| cysteine | | cysteinium | fundamental metabolite | 1986 | 2002 | 33.3 | high | 0 | 7 | 7 | 1 | 0 | 0 |
| s-(1,2-dichlorovinyl)cysteine | | S-(1,2-dichlorovinyl)-L-cysteine | | 1990 | 1997 | 29.7 | low | 0 | 0 | 3 | 0 | 0 | 0 |
| s-(1,2-dichlorovinyl)glutathione | | peptide | | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| s-(1,2-dichlorovinyl)homocysteine | | | | 1990 | 2002 | 28.0 | high | 0 | 0 | 1 | 1 | 0 | 0 |
| n-acetyl-s-pentachloro-1,3-butadienylcysteine | | | | 1986 | 1986 | 38.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| ascorbic acid | | ascorbic acid;
vitamin C | coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
Cytotoxicity of S-(1,2,3,4,4-pentachlorobutadienyl)-L cysteine after apical and basolateral exposure of LLC-PK monolayers. Involvement of an amino acid transport system.Chemico-biological interactions, , Volume: 75, Issue:1, 1990
Bioactivation of hexachlorobutadiene by glutathione conjugation.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, , Volume: 28, Issue:4, 1990
Nephrotoxicity of hexachlorobutadiene and its glutathione-derived conjugates.Toxicologic pathology, , Volume: 14, Issue:2, 1986
| Article | Year |
|---|
Biotransformation, excretion and nephrotoxicity of haloalkene-derived cysteine S-conjugates.
Archives of toxicology, , Volume: 72, Issue:1 | 1997 |
Assessment of the role of glutathione conjugation in the protection afforded by anethol dithiolthione against hexachloro-1,3-butadiene-induced nephrotoxicity.
Toxicology and applied pharmacology, , Volume: 139, Issue:1 | 1996 |
In vivo and in vitro nephrotoxicity of the cysteine conjugate of hexachlorobutadiene.
Journal of toxicology and environmental health, , Volume: 11, Issue:4-6 | |
Nephrotoxicity of hexachlorobutadiene and its glutathione-derived conjugates.
Toxicologic pathology, , Volume: 14, Issue:2 | 1986 |
Toxicity of S-pentachlorobutadienyl-L-cysteine studied with isolated rat renal cortical mitochondria.
Archives of biochemistry and biophysics, , Nov-01, Volume: 258, Issue:2 | 1987 |
A mechanism of S-(1,2,3,4,4-pentachloro-1,3-butadienyl)-L-cysteine toxicity to rabbit renal proximal tubules.
Toxicology and applied pharmacology, , Sep-30, Volume: 90, Issue:3 | 1987 |
Cytotoxicity of S-(1,2,3,4,4-pentachlorobutadienyl)-L cysteine after apical and basolateral exposure of LLC-PK monolayers. Involvement of an amino acid transport system.
Chemico-biological interactions, , Volume: 75, Issue:1 | 1990 |
Renal cysteine conjugate beta-lyase-mediated toxicity studied with primary cultures of human proximal tubular cells.
Toxicology and applied pharmacology, , Volume: 103, Issue:3 | 1990 |
Pentachlorobutadienyl-L-cysteine (PCBC) toxicity: the importance of mitochondrial dysfunction.
Journal of biochemical toxicology, ,Winter, Volume: 6, Issue:4 | 1991 |