Carboxypeptidase B2

A carboxypeptidase B2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96IY4]

Synonyms

EC 3.4.17.20;
Carboxypeptidase U;
CPU;
Plasma carboxypeptidase B;
pCPB;
Thrombin-activable fibrinolysis inhibitor;
TAFI

Research

Bioassay Publications (6)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (50.00)	29.6817
2010's	3 (50.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (5)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
benzylsuccinic acid	Homo sapiens (human)	Ki	0.4500	1	1
n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	Homo sapiens (human)	IC50	1.8000	1	1
vorinostat	Homo sapiens (human)	IC50	0.3620	1	1
sq 24798	Homo sapiens (human)	IC50	0.0080	1	1
sq 24798	Homo sapiens (human)	Ki	0.0040	1	1
anabaenopeptin b	Homo sapiens (human)	IC50	0.0015	1	1

Enables

This protein enables 2 target(s):

Target	Category	Definition
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
metallocarboxypeptidase activity	molecular function	Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]

Involved In

This protein is involved in 11 target(s):

Target	Category	Definition
positive regulation of extracellular matrix constituent secretion	biological process	Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells. [GOC:dph, GOC:tb]
blood coagulation	biological process	The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. [PMID:30700128]
response to xenobiotic stimulus	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc]
negative regulation of plasminogen activation	biological process	Any process that decreases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin. [GOC:BHF, GOC:dph, GOC:tb]
protein catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. [GOC:mah]
negative regulation of fibrinolysis	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots. [GOC:ai]
cellular response to glucose stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. [GOC:mah]
liver regeneration	biological process	The regrowth of lost or destroyed liver. [GOC:gap, PMID:19447520]
negative regulation of hepatocyte proliferation	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte proliferation. [GOC:BHF, GOC:mah]
proteolysis	biological process	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
fibrinolysis	biological process	A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin. [GOC:jl, PMID:15842654]