acetaminophen and Necrosis
acetaminophen has been researched along with Necrosis in 423 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"Although considered safe at therapeutic doses, at higher doses, acetaminophen produces a centrilobular hepatic necrosis that can be fatal." | 8.86 | Mechanisms of acetaminophen-induced liver necrosis. ( Hinson, JA; James, LP; Roberts, DW, 2010) |
"Prevention of liver failure arising from accidental or deliberate paracetamol (acetaminophen [APAP]) overdose remains a vexed health problem despite well-publicized guidelines for its early detection and treatment." | 8.31 | Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver. ( Alabbas, SY; Begun, J; Davies, J; Florin, TH; Giri, R; Oancea, I; Schreibner, V, 2023) |
"Acetaminophen (APAP) overdose-induced acute liver injury (AILI) is a significant clinical problem worldwide, the hepatotoxicity mechanisms are well elucidated, but the factors involved in the necrosis and repair still remain to be investigated." | 7.91 | Integrative proteomics and immunochemistry analysis of the factors in the necrosis and repair in acetaminophen-induced acute liver injury in mice. ( Dai, G; Feng, Q; Liang, C; Liu, L; Luo, L; Sun, J; Xia, W; Yang, J; Zhao, N, 2019) |
"The degree of liver inflammation and hepatocellular necrosis were significantly higher in HFGD fed animals after acetaminophen administration." | 7.78 | Susceptibility of rat non-alcoholic fatty liver to the acute toxic effect of acetaminophen. ( Cervinková, Z; Haňáčková, L; Kučera, O; Lotková, H; Podhola, M; Roušar, T; Staňková, P, 2012) |
" Using a high-resolution and high-magnification multiphoton microscopic system, we recorded in living mice serial changes of acetaminophen (APAP)-induced hepatocyte necrosis in relevance to metabolism of a fluorogenic bile solute." | 7.77 | Apical membrane rupture and backward bile flooding in acetaminophen-induced hepatocyte necrosis. ( Chiou, LL; Dong, CY; Huang, GT; Lee, HS; Li, FC; Lin, CJ; Lo, SY; Lo, W; Sun, TL; Wang, SS, 2011) |
" Hepatocyte apoptosis, necrosis, and innate immune activation have been defined as features of the toxicological response associated with the hepatotoxin acetaminophen (APAP)." | 7.75 | High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo. ( Antoine, DJ; Jenkins, RE; Kipar, A; Kitteringham, NR; Park, BK; Regan, SL; Sathish, JG; Williams, DP, 2009) |
"A 28-year-old man with schizophrenia intentionally ingested a lethal dose of acetaminophen and an unknown quantity of ibuprofen." | 7.74 | Rhabdomyolysis and necrotic bowel after acetaminophen and ibuprofen overdose. ( Dunn, T; Katz, D; Nelson, H; Singh, G; Thomsen, D; Voigt, M; Whitaker, E, 2007) |
"An overdose of acetaminophen (APAP) (N-acetyl-p-aminophenol) leads to hepatocellular necrosis induced by its metabolite N-acetyl-p-benzoquinone-imine, which is generated during the metabolic phase of liver intoxication." | 7.73 | Deoxyribonuclease 1 aggravates acetaminophen-induced liver necrosis in male CD-1 mice. ( Apostolov, EO; Basnakian, AG; Mannherz, HG; Napirei, M, 2006) |
"The hypothesis that acetaminophen can reduce necrosis during myocardial infarction was tested in male dogs." | 7.72 | Acetaminophen and myocardial infarction in dogs. ( Golfetti, R; Merrill, GF; Rork, TH; Spiler, NM, 2004) |
"This study of acetaminophen (AAP) hepatotoxicity examined whether some aspects of the highly integrated process of drug-induced toxicity involves apoptosis, in addition to necrosis in vivo; and if so, whether cholesteryl hemisuccinate (CS) pretreatment would selectively interfere with apoptotic or necrotic liver cell death." | 7.69 | Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment. ( Fariss, MW; Mumaw, VR; Raje, RR; Ray, SD, 1996) |
"The relationship between serum aminotransferase levels and the acute hepatic necrosis induced by acetaminophen was studied in 24 male Wistar rats (220-265 g)." | 7.69 | Correlation between the severity of acute hepatic necrosis induced by acetaminophen and serum aminotransferase levels in fasted and sucrose-fed rats. ( Collares, EF; De-Santi-Neto, D; Hessel, G, 1996) |
"Vascular congestion and liver swelling have long been recognized as features of the hepatotoxic effects of acetaminophen (AAP) in mice and rats and have been proposed as contributing factors to the eventual extent of necrosis produced." | 7.68 | Investigation of possible mechanisms of hepatic swelling and necrosis caused by acetaminophen in mice. ( Benzick, AE; Hansen, TN; Montgomery, CA; Smith, CV; Welty, SE, 1993) |
" After 10 days of feeding acetaminophen was administered intraperitoneally in amounts known to induce liver necrosis (500 mg/kg)." | 7.67 | Protective action of 2(3)-tert-butyl-4-hydroxyanisole (BHA) on acetaminophen-induced liver necrosis in male A/J mice. ( Boroujerdi, M; Carlo, JR; Rosenbaum, SE, 1984) |
"A 63-year-old man with acute psittacosis had severe hepatic damage after ingesting about 10 g of acetaminophen over a 48 hour period." | 7.66 | Severe hepatic damage after acetaminophen use in psittacosis. ( Davis, AM; Helms, CM; LaBrecque, DR; Mitros, FA; Wong, YW, 1983) |
"A preliminary trial was conducted to determine if cimetidine would prevent acetaminophen-induced hepatic necrosis." | 7.66 | Prevention of acetaminophen-induced hepatic necrosis by cimetidine in mice. ( Donn, KH; Grisham, JW; Rudd, GD, 1981) |
"In an attempt to elucidate the biochemical mechanism of acetaminophen-induced hepatic necrosis, the present study in hamsters was undertaken to evaluate the possible changes in lipid peroxidation and microsomal enzyme activities." | 7.66 | Experimental acetaminophen-induced hepatic necrosis: biochemical and electron microscopic study of cysteamine protection. ( Bhakthan, NM; Chiu, S, 1978) |
"60 patients with paracetamol poisoning have been treated with intravenous cysteamine, L-methionine, or D-penicillamine and the incidence and severity of hepatic necrosis compared with those observed in 70 patients receiving supportive therapy only." | 7.65 | Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. ( Park, J; Prescott, LF; Proudfoot, AT; Smith, IJ; Sutherland, GR, 1976) |
"Acetaminophen (APAP) is a widely used analgesic drug, which can cause severe liver injury after an overdose." | 6.66 | Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity. ( Jaeschke, H; Ramachandran, A, 2020) |
"Coenzyme Q10 (CoQ10) which acts as an electron transporter in the mitochondrial respiratory chain has many beneficial effects on liver diseases." | 5.62 | CoQ10 Promotes Resolution of Necrosis and Liver Regeneration After Acetaminophen-Induced Liver Injury. ( Chen, S; Chen, X; Fang, W; He, T; Tang, Y; Zhang, P, 2021) |
"Acetaminophen (APAP) is a known hepatotoxin predictably causing intrinsic DILI." | 5.62 | Boldine treatment protects acetaminophen-induced liver inflammation and acute hepatic necrosis in mice. ( Ezhilarasan, D; Raghunandhakumar, S, 2021) |
" HMGB1 acts as a danger-associated molecular patterns during this toxic process but the mechanisms of action and targeted cells are incompletely defined." | 5.56 | New insights in acetaminophen toxicity: HMGB1 contributes by itself to amplify hepatocyte necrosis in vitro through the TLR4-TRIF-RIPK3 axis. ( Devière, J; Dressen, C; Gustot, T; Leclercq, I; Lemmers, A; Liefferinckx, C; Minsart, C; Moreau, R; Quertinmont, E, 2020) |
"Acetaminophen (APAP) is a common antipyretic and analgesic drug, but its overdose can induce acute liver failure with lack of effective therapies." | 5.56 | Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via upregulation of heme oxygenase-1 expression. ( Chen, Y; He, Z; Jiang, R; Kuang, G; Wan, J; Ye, D; Zhang, L, 2020) |
"Acetaminophen (APAP) is a readily available and safe painkiller." | 5.46 | Fast food diet-induced non-alcoholic fatty liver disease exerts early protective effect against acetaminophen intoxication in mice. ( Choi, D; Kim, JY; Kim, TH; Koo, SH; Lee, JH, 2017) |
"Patient 1 was admitted with acute liver failure following acetaminophen intoxication." | 5.35 | Apoptosis versus necrosis rate as a predictor in acute liver failure following acetaminophen intoxication compared with acute-on-chronic liver failure. ( Bechmann, LP; Canbay, A; Gerken, G; Jochum, C; Marquitan, G; Saner, F, 2008) |
"Acetaminophen (paracetamol) is an analgesic-antipyretic drug virtually devoid of typical anti-inflammatory activity and hence free of some of the side-effects of aspirin and related agents (e." | 5.32 | Long-term acetaminophen (paracetamol) treatment causes liver and kidney ultra-structural changes during rat pregnancy. ( Kulay, L; Neto, JA; Oliveira-Filho, RM; Simões, MJ; Soares, JM, 2004) |
"Hypothyroidism was induced by methimazole, propylthiouracil, or surgical thyroidectomy and confirmed by elevated serum levels of TSH." | 5.30 | Hypothyroidism protects rat liver from acetaminophen hepatotoxicity. ( Aeed, H; Avni, Y; Bruck, R; Frenkel, D; Halpern, Z; Matas, Z; Oren, R; Papa, M; Shirin, H; Zaidel, L, 1999) |
" These data cannot support the concept that induction of cytochrome P-450 leads to greater formation of the hypothetical toxic metabolite of acetaminophen, or that induction enhances its hepatotoxicity, in the rat." | 5.27 | Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat. ( Lerche, A; Pedersen, NT; Poulsen, HE, 1985) |
"Although considered safe at therapeutic doses, at higher doses, acetaminophen produces a centrilobular hepatic necrosis that can be fatal." | 4.86 | Mechanisms of acetaminophen-induced liver necrosis. ( Hinson, JA; James, LP; Roberts, DW, 2010) |
"Prevention of liver failure arising from accidental or deliberate paracetamol (acetaminophen [APAP]) overdose remains a vexed health problem despite well-publicized guidelines for its early detection and treatment." | 4.31 | Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver. ( Alabbas, SY; Begun, J; Davies, J; Florin, TH; Giri, R; Oancea, I; Schreibner, V, 2023) |
"Acetaminophen (APAP) overdose can cause hepatotoxicity by inducing mitochondrial damage and subsequent necrosis in hepatocytes." | 3.91 | Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury: possible involvement of ER stress and S6K1 activation. ( Bae, SH; Cho, Y; Jo, Y; Kim, HS; Kim, JH; Lee, B; Lee, DH; Lee, YH; Lee, YS; Nam, KT; Park, JS, 2019) |
"Acetaminophen (APAP) overdose-induced acute liver injury (AILI) is a significant clinical problem worldwide, the hepatotoxicity mechanisms are well elucidated, but the factors involved in the necrosis and repair still remain to be investigated." | 3.91 | Integrative proteomics and immunochemistry analysis of the factors in the necrosis and repair in acetaminophen-induced acute liver injury in mice. ( Dai, G; Feng, Q; Liang, C; Liu, L; Luo, L; Sun, J; Xia, W; Yang, J; Zhao, N, 2019) |
" We induced in vivo hepatocyte necrosis and apoptosis in mice deficient in DNase1L3 (also named DNase γ) and/or caspase-activated DNase (CAD) genes with acetaminophen overdose and anti-Fas antibody treatments." | 3.91 | Cell-free DNA in blood circulation is generated by DNase1L3 and caspase-activated DNase. ( Mizuta, R; Takada, S; Watanabe, T, 2019) |
" N-acetyl-p-aminophenol (APAP), commonly known as acetaminophen, generates excessive oxidative stress and triggers hepatocyte cell death, exemplified by regulated necrosis." | 3.88 | Exogenous recombinant human thioredoxin-1 prevents acetaminophen-induced liver injury by scavenging oxidative stressors, restoring the thioredoxin-1 system and inhibiting receptor interacting protein-3 overexpression. ( Jeon, BS; Lee, BW; Yoon, BI, 2018) |
"Acetaminophen (APAP) overdose induces severe oxidative stress followed by hepatocyte apoptosis/necrosis." | 3.85 | Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress. ( Aoyama, T; Arai, K; Ikejima, K; Kon, K; Kusama, H; Uchiyama, A; Watanabe, S; Yamashina, S, 2017) |
" Liver histology showed more intense centrilobular necrosis in splenectomized group in comparison to the others, suggesting a protective role of spleen in acetaminophen-induced liver injury." | 3.85 | Autotransplantation of Spleen Mitigates Drug-Induced Liver Damage in Splenectomized Mice. ( Almeida, CS; de Oliveira, EE; de Paoli, F; Figueiredo, BBM; Grunewald, STF; Mendonça, ACP; Rezende, AB; Teixeira, HC, 2017) |
" Acetaminophen is a commonly used antipyretic agent, which in high doses, causes uremia and used for experimentally induction of kidney disease." | 3.81 | Therapeutic potential of different commercially available synbiotic on acetaminophen-induced uremic rats. ( Das, K; Mahapatra, SD; Mahapatra, TD; Mandal, A; Mandal, S; Mondal, KC; Nandi, DK; Patra, A; Paul, T; Roy, S, 2015) |
"Although necrosis in the acetaminophen (APAP) model is known to be regulated by c-Jun NH2-terminal kinase (JNK) through interaction with mitochondria, the role of necroptosis through receptor-interacting proteins 1 and 3 (RIPK1 and RIPK3) has also been suggested." | 3.81 | Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis. ( Dara, L; Gaarde, W; Han, D; Johnson, H; Kaplowitz, N; Suda, J; Win, S, 2015) |
" A 55-year-old female was admitted to the burn unit (West Penn Burn Center, Western Pennsylvania Hospital, Pittsburgh, PA) after she initially presented with infection and cellulitis to her bilateral upper extremities 3 weeks after intravenously injecting herself with crushed oxycodone/acetaminophen." | 3.81 | Subcutaneous Injection of Percocet: A Case of Severe Soft Tissue Loss. ( Aballay, AM; Abboud, C; Baskin, SM; Chen, W; Kelly, RW; Tolchin, E, 2015) |
" After acetaminophen intoxication, necrosis was significantly increased in TAFI-/- mice at 24 hours (h) after injection." | 3.79 | TAFI deficiency promotes liver damage in murine models of liver failure through defective down-regulation of hepatic inflammation. ( Adelmeijer, J; Hugenholtz, GC; Lisman, T; Meijers, JC; Porte, RJ, 2013) |
"Inappropriate use of acetaminophen (APAP) can lead to morbidity and mortality secondary to hepatic necrosis." | 3.79 | Korean red ginseng extract prevents APAP-induced hepatotoxicity through metabolic enzyme regulation: the role of ginsenoside Rg3, a protopanaxadiol. ( Cho, MK; Gum, SI, 2013) |
"The degree of liver inflammation and hepatocellular necrosis were significantly higher in HFGD fed animals after acetaminophen administration." | 3.78 | Susceptibility of rat non-alcoholic fatty liver to the acute toxic effect of acetaminophen. ( Cervinková, Z; Haňáčková, L; Kučera, O; Lotková, H; Podhola, M; Roušar, T; Staňková, P, 2012) |
"Full length keratin-18 (FL-K18) and High Mobility Group Box-1 (HMGB1) represent circulating indicators of necrosis during acetaminophen (APAP) hepatotoxicity in vivo." | 3.78 | RETRACTED: Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity. ( Antoine, DJ; Craig, DG; Dear, JW; Jaeschke, H; Jenkins, RE; McGill, MR; Park, BK; Sharpe, MR; Simpson, KJ; Williams, DP, 2012) |
" Ozone therapy (OT) is shown to reduce inflammation and necrosis in several entities." | 3.78 | The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury. ( Akgul, EO; Cakir, E; Cayci, T; Demirbag, S; Eyi, YE; Gul, H; Kaldirim, U; Korkmaz, A; Macit, E; Oter, S; Ozler, M; Oztas, E; Topal, T; Toygar, M; Uysal, B; Yaman, H; Yildirim, AO, 2012) |
" Acetaminophen is a commonly used analgesic and antipyretic agent which, at high doses, causes liver and kidney necrosis in man and animals." | 3.77 | Evaluation of phytoconstituents and anti-nephrotoxic and antioxidant activities of Monochoria vaginalis. ( Kumar, BS; Kumar, RP; Palani, S; Raja, S; Selvaraj, R, 2011) |
" Using a high-resolution and high-magnification multiphoton microscopic system, we recorded in living mice serial changes of acetaminophen (APAP)-induced hepatocyte necrosis in relevance to metabolism of a fluorogenic bile solute." | 3.77 | Apical membrane rupture and backward bile flooding in acetaminophen-induced hepatocyte necrosis. ( Chiou, LL; Dong, CY; Huang, GT; Lee, HS; Li, FC; Lin, CJ; Lo, SY; Lo, W; Sun, TL; Wang, SS, 2011) |
"Recently, it was reported that the intraperitoneal administration of 30 mg/kg/day troglitazone to heterozygous superoxide dismutase 2 gene knockout (Sod2+/-) mice for twenty-eight days caused liver injury, manifested by increased serum ALT activity and hepatic necrosis." | 3.75 | Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen. ( Ando, Y; Arakawa, S; Fujimoto, K; Ito, K; Kumagai, K; Manabe, S; Oda, S; Yamoto, T, 2009) |
" As a result, pretreated with ASE prior to the administration of APAP significantly prevented the increases of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and tumor necrosis factor-alpha (TNF-alpha) levels in serum, and glutathione (GSH) depletion, malondialdehyde (MDA) accumulation in liver tissue." | 3.75 | Protective Effects of the Supernatant of Ethanol Eluate from Artemisia sacrorum Ledeb. against Acetaminophen-Induced Liver Injury in Mice [corrected]. ( Jin, GZ; Piao, GC; Yuan, HD, 2009) |
" We utilized acetaminophen (APAP) as a model hepatotoxicant that gives a multifocal pattern of necrosis following toxic doses." | 3.74 | Gene expression analysis offers unique advantages to histopathology in liver biopsy evaluations. ( Boorman, GA; Flagler, ND; Foley, JF; Heinloth, AN; Paules, RS, 2007) |
"A 28-year-old man with schizophrenia intentionally ingested a lethal dose of acetaminophen and an unknown quantity of ibuprofen." | 3.74 | Rhabdomyolysis and necrotic bowel after acetaminophen and ibuprofen overdose. ( Dunn, T; Katz, D; Nelson, H; Singh, G; Thomsen, D; Voigt, M; Whitaker, E, 2007) |
" One from a heart disease study and another from acetaminophen (an analgesic) exposure in rat liver that causes centrilobular necrosis." | 3.74 | Simultaneous clustering of gene expression data with clinical chemistry and pathological evaluations reveals phenotypic prototypes. ( Bushel, PR; Gibson, G; Wolfinger, RD, 2007) |
" As model toxic compounds lipopolysaccharide (LPS, inducing inflammation), paracetamol (necrosis), carbon tetrachloride (CCl(4), fibrosis and necrosis) and gliotoxin (apoptosis) were used." | 3.74 | Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity. ( Bauerschmidt, S; Draaisma, AL; Elferink, MG; Groothuis, GM; Merema, MT; Olinga, P; Polman, J; Schoonen, WG, 2008) |
" Adult Sprague-Dawley rats treated with acetaminophen or D-galactosamine (GalN) showed dose- and time-dependent histomorphological changes and TUNEL staining in liver consistent with hepatocellular necrosis, apoptosis and inflammation up to 72 h." | 3.74 | Cytochrome c: a non-invasive biomarker of drug-induced liver injury. ( Adeyemo, O; Hanig, JP; Knapton, A; Miller, TJ; Noory, L; Weaver, J, 2008) |
"The results indicate that WLP-S-10 is a novel potential compound against acetaminophen-induced acute liver failure in mice, and its active mechanism is mainly related to protection against necrosis and apoptosis of hepatocytes through inhibition of mitochondrial energy (ATP) depletion and AIF and cytochrome C release." | 3.74 | Protection by bicyclol derivatives against acetaminophen-induced acute liver failure in mice and its active mechanism. ( Hou, Y; Li, L; Liu, G; Tong, Y; Wei, H; Wu, L; Wu, S, 2008) |
"The acetaminophen (APAP)-induced hepatic centrilobular necrosis is preceded by hepatic microcirculatory dysfunction including the infiltration of erythrocytes into the space of Disse." | 3.73 | Inhibition of matrix metalloproteinases minimizes hepatic microvascular injury in response to acetaminophen in mice. ( Abril, ER; Bethea, NW; Ito, Y; McCuskey, RS, 2005) |
"An overdose of acetaminophen (APAP) (N-acetyl-p-aminophenol) leads to hepatocellular necrosis induced by its metabolite N-acetyl-p-benzoquinone-imine, which is generated during the metabolic phase of liver intoxication." | 3.73 | Deoxyribonuclease 1 aggravates acetaminophen-induced liver necrosis in male CD-1 mice. ( Apostolov, EO; Basnakian, AG; Mannherz, HG; Napirei, M, 2006) |
" Similarly, Fah(-/-) animals with liver injury were also resistant to apoptosis induced by the Fas ligand Jo-2 and to necrosis-like cell death induced by acetaminophen (APAP)." | 3.72 | Chronic liver disease in murine hereditary tyrosinemia type 1 induces resistance to cell death. ( Al-Dhalimy, M; Finegold, M; Grompe, M; Groopman, J; Iordanov, MS; Ou, CN; Ryabinina, O; van Den Berg, IE; Vogel, A, 2004) |
"The hypothesis that acetaminophen can reduce necrosis during myocardial infarction was tested in male dogs." | 3.72 | Acetaminophen and myocardial infarction in dogs. ( Golfetti, R; Merrill, GF; Rork, TH; Spiler, NM, 2004) |
" However, careful comparison of transgenic and nontransgenic mice revealed two phenotypic differences: mDuffy-transgenic mice exhibited a diminished angiogenic response to MIP-2 in the corneal micropocket assay, and mDuffy-transgenic mice exhibited enhanced hepatocellular toxicity and necrosis as compared with nontransgenic littermates in response to overdose of acetaminophen (APAP; 400 mg/kg body weight)." | 3.71 | Potential role for Duffy antigen chemokine-binding protein in angiogenesis and maintenance of homeostasis in response to stress. ( Chen, TS; Daniel, TO; Du, J; Horton, LW; Liu, H; Luan, J; Nanney, LB; Peiper, S; Richmond, A; Strieter, RM; Yu, Y, 2002) |
"The effect of reduced glutathione (GSH) depletion by acetaminophen (APAP), diethylmaleate (DEM), or phorone on the mode of cell death and susceptibility to tumor necrosis factor (TNF)-induced cell death was studied in cultured mouse hepatocytes." | 3.71 | Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes. ( Feng, G; Kaplowitz, N; Matsumaru, K; Nagai, H, 2002) |
"Hepatotoxic doses of acetaminophen to mice produce not only acetaminophen-protein adducts in the centrilobular cells of the liver, but nitrotyrosine-protein adducts in the same cells, the site of the necrosis." | 3.70 | Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species. ( Hinson, JA; Mayeux, PR; Michael, SL; Niesman, MR; Pumford, NR, 1999) |
"The hepatic centrilobular necrosis produced by the analgesic/antipyretic acetaminophen correlates with metabolic activation of the drug leading to its covalent binding to protein." | 3.70 | Western blot analysis for nitrotyrosine protein adducts in livers of saline-treated and acetaminophen-treated mice. ( Ault, SG; Hinson, JA; Michael, SL; Pumford, NR, 2000) |
"The mechanism(s) of liver damage initiated by ingestion of toxic components of thermally oxidized lipids was compared in a rat model with the documented mechanisms of hepatic failure and necrosis initiated by acetaminophen." | 3.69 | Comparison of thermally oxidized lipids and acetaminophen with concurrent consumption of ethanol as inducers of liver cirrhosis. ( Fouad, FM; Mamer, OA; Shahidi, F, 1995) |
"A case of fatal paracetamol (acetaminophen) poisoning in a 26-year-old woman who developed liver necrosis is described." | 3.69 | [A case of paracetamol retard poisoning with fatal outcome]. ( Lystbaek, BB; Nørregaard, P, 1995) |
"Administration of hepatotoxic doses of acetaminophen (APAP) to mice results in necrosis, not only of liver cells but of renal proximal tubules and bronchiolar and olfactory epithelium." | 3.69 | Immunohistochemical localization of acetaminophen in target tissues of the CD-1 mouse: correspondence of covalent binding with toxicity. ( Cartun, RW; Cohen, SD; Hart, SG; Khairallah, EA; Wyand, DS, 1995) |
"We have analysed Kupffer cell and 'activated' perisinusoidal cell populations in liver biopsies from patients with paracetamol (acetaminophen)-induced hepatic necrosis of varying degrees of severity." | 3.69 | Non-parenchymal cell responses in paracetamol (acetaminophen)-induced liver injury. ( Burt, AD; Hines, JE; James, OF; Mathew, J, 1994) |
"When administered four hours after a toxic dose of acetaminophen, 4-methylpyrazole significantly inhibits hepatotoxicity in the rat, as reflected by lower levels of serum transaminases and lesser degrees of hepatic necrosis." | 3.69 | 4-Methylpyrazole blocks acetaminophen hepatotoxicity in the rat. ( Baevsky, RH; Brennan, RJ; DelVecchio, JA; Lefevre, R; Mankes, RF; Raccio-Robak, N; Zink, BJ, 1994) |
"This study of acetaminophen (AAP) hepatotoxicity examined whether some aspects of the highly integrated process of drug-induced toxicity involves apoptosis, in addition to necrosis in vivo; and if so, whether cholesteryl hemisuccinate (CS) pretreatment would selectively interfere with apoptotic or necrotic liver cell death." | 3.69 | Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment. ( Fariss, MW; Mumaw, VR; Raje, RR; Ray, SD, 1996) |
" An abdominal enhanced CT scan revealed a wedge-shaped region of devitalised liver with associated free intraperitoneal fluid, consistent with a traumatic lesion but due to necrosis secondary to acetaminophen toxicity." | 3.69 | Hepatic necrosis masquerading as trauma. ( Anderson, B; Cluroe, A; Duncan, D, 1997) |
"The relationship between serum aminotransferase levels and the acute hepatic necrosis induced by acetaminophen was studied in 24 male Wistar rats (220-265 g)." | 3.69 | Correlation between the severity of acute hepatic necrosis induced by acetaminophen and serum aminotransferase levels in fasted and sucrose-fed rats. ( Collares, EF; De-Santi-Neto, D; Hessel, G, 1996) |
"Vascular congestion and liver swelling have long been recognized as features of the hepatotoxic effects of acetaminophen (AAP) in mice and rats and have been proposed as contributing factors to the eventual extent of necrosis produced." | 3.68 | Investigation of possible mechanisms of hepatic swelling and necrosis caused by acetaminophen in mice. ( Benzick, AE; Hansen, TN; Montgomery, CA; Smith, CV; Welty, SE, 1993) |
" The objective of the present investigation was to study some of the possible mechanisms involved in the protective effect of sucrose ingestion against liver necrosis induced by acetaminophen." | 3.68 | Cytochrome P450 and glutathione in the liver of rats under exclusive sucrose ingestion. ( Martinelli, AL; Meneghelli, UG; Zucoloto, S, 1993) |
"Ca2+ accumulates in the nucleus and DNA undergoes enzymatic cleavage into internucleosome-length fragments before acetaminophen and dimethylnitrosamine produce hepatic necrosis in vivo and toxic cell death in vitro." | 3.68 | Ca2+ antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen. ( Corcoran, GB; Gurule, MW; Kamendulis, LM; Ray, SD; Yorkin, RD, 1993) |
" After 10 days of feeding acetaminophen was administered intraperitoneally in amounts known to induce liver necrosis (500 mg/kg)." | 3.67 | Protective action of 2(3)-tert-butyl-4-hydroxyanisole (BHA) on acetaminophen-induced liver necrosis in male A/J mice. ( Boroujerdi, M; Carlo, JR; Rosenbaum, SE, 1984) |
"We report a case of fulminant hepatic necrosis occurring in the setting of acetaminophen overdose and chronic alcohol use." | 3.67 | Long-term sequellae of acetaminophen-associated fulminant hepatic failure: relevance of early histology. ( Baeg, NJ; Bodenheimer, HC; Burchard, K, 1988) |
"Acetaminophen is a common drug used in pregnancy." | 3.67 | Maternal acetaminophen overdose at 15 weeks of gestation. ( Gabbe, SG; Landon, MB; Ludmir, J; Main, DM, 1986) |
"A 63-year-old man with acute psittacosis had severe hepatic damage after ingesting about 10 g of acetaminophen over a 48 hour period." | 3.66 | Severe hepatic damage after acetaminophen use in psittacosis. ( Davis, AM; Helms, CM; LaBrecque, DR; Mitros, FA; Wong, YW, 1983) |
"Both phenacetin and paracetamol produce acute centrilobular liver necrosis in the homozygous Gunn rat." | 3.66 | Hepatotoxicity of phenacetin and paracetamol in the Gunn rat. ( Calder, IC; Hart, SJ; Smail, MC; Tange, JD, 1981) |
" Acetylcysteine prevents liver necrosis caused by acetaminophen, and some possible mechanisms are discussed." | 3.66 | An integrated approach to the study of chemically reactive metabolites of acetaminophen. ( Gillette, JR, 1981) |
"In an attempt to elucidate the biochemical mechanism of acetaminophen-induced hepatic necrosis, the present study in hamsters was undertaken to evaluate the possible changes in lipid peroxidation and microsomal enzyme activities." | 3.66 | Experimental acetaminophen-induced hepatic necrosis: biochemical and electron microscopic study of cysteamine protection. ( Bhakthan, NM; Chiu, S, 1978) |
"60 patients with paracetamol poisoning have been treated with intravenous cysteamine, L-methionine, or D-penicillamine and the incidence and severity of hepatic necrosis compared with those observed in 70 patients receiving supportive therapy only." | 3.65 | Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. ( Park, J; Prescott, LF; Proudfoot, AT; Smith, IJ; Sutherland, GR, 1976) |
"Experimental hepatic necrosis was induced in phenobarbital pretreated rats by means of the intraperitoneal administration of an acetaminophen-dimethyl sulfixide (DMSO) mixture." | 3.65 | Experimental hepatic injury: the sequential changes in drug metabolizing enzyme activities after administration of acetaminophen. ( Hart, FE; Willson, RA, 1977) |
"Drug-metabolizing capacity has been assessed by serial measurements of the plasma antipyrine half life in 11 patients with severe barbiturate intoxication and in 17 patients with acute hepatic necrosis due to paracetamol overdosage." | 3.65 | Abnormal drug metabolism after barbiturate and paracetamol overdose. ( Forrest, JA; Prescott, LF; Roscoe, P; Stevenson, IH, 1974) |
"Acetaminophen (APAP) is a widely used analgesic drug, which can cause severe liver injury after an overdose." | 2.66 | Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity. ( Jaeschke, H; Ramachandran, A, 2020) |
"Necrosis is typically the consequence of acute metabolic perturbation with ATP depletion as occurs in ischemia/reperfusion and acute drug-induced hepatotoxicity." | 2.43 | Apoptosis and necrosis in the liver: a tale of two deaths? ( Gores, GJ; Lemasters, JJ; Malhi, H, 2006) |
"Acetaminophen has become a very popular over-the-counter analgesic in some countries and as a result it is used increasingly as an agent for self-poisoning." | 2.36 | The treatment of acetaminophen poisoning. ( Critchley, JA; Prescott, LF, 1983) |
"Pretreatment with nicorandil reduced serum levels of aminotransferases, bilirubin, GGT and LDH, and increased serum level of albumin." | 1.91 | Hepatoprotective effect of nicorandil against acetaminophen-induced oxidative stress and hepatotoxicity in mice via modulating NO synthesis. ( El-Kashef, DH; Sharawy, MH, 2023) |
"Anisomycin and SP600125 were used as JNK activator and inhibitor, respectively, and NAC served as a positive control." | 1.91 | Fluorofenidone protects against acute liver failure in mice by regulating MKK4/JNK pathway. ( Gu, L; He, X; Hu, G; Huang, H; Li, S; Liu, X; Ma, R; Meng, J; Peng, Y; Peng, Z; Tang, J; Tao, L; Xie, Y; Yang, H; Yang, X; Zhang, Y, 2023) |
"Leonurine (Leo) is a natural alkaloid isolated from the herb Leonurus japonicus Houtt." | 1.91 | Leonurine alleviates acetaminophen-induced acute liver injury by regulating the PI3K/AKT signaling pathway in mice. ( Chen, Y; Di, S; Huang, X; Wang, Y; Yu, Y; Zhou, S, 2023) |
"Rosiglitazone pretreatment can alleviate APAP-induced ALI by suppressing three branches of ERS signaling." | 1.72 | Rosiglitazone Protects against Acetaminophen-Induced Acute Liver Injury by Inhibiting Multiple Endoplasmic Reticulum Stress Pathways. ( Cao, Y; He, W; Huang, J; Li, X; Wang, J, 2022) |
"Coenzyme Q10 (CoQ10) which acts as an electron transporter in the mitochondrial respiratory chain has many beneficial effects on liver diseases." | 1.62 | CoQ10 Promotes Resolution of Necrosis and Liver Regeneration After Acetaminophen-Induced Liver Injury. ( Chen, S; Chen, X; Fang, W; He, T; Tang, Y; Zhang, P, 2021) |
"Acetaminophen (APAP) is a known hepatotoxin predictably causing intrinsic DILI." | 1.62 | Boldine treatment protects acetaminophen-induced liver inflammation and acute hepatic necrosis in mice. ( Ezhilarasan, D; Raghunandhakumar, S, 2021) |
" HMGB1 acts as a danger-associated molecular patterns during this toxic process but the mechanisms of action and targeted cells are incompletely defined." | 1.56 | New insights in acetaminophen toxicity: HMGB1 contributes by itself to amplify hepatocyte necrosis in vitro through the TLR4-TRIF-RIPK3 axis. ( Devière, J; Dressen, C; Gustot, T; Leclercq, I; Lemmers, A; Liefferinckx, C; Minsart, C; Moreau, R; Quertinmont, E, 2020) |
"Acetaminophen (APAP) is a common antipyretic and analgesic drug, but its overdose can induce acute liver failure with lack of effective therapies." | 1.56 | Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via upregulation of heme oxygenase-1 expression. ( Chen, Y; He, Z; Jiang, R; Kuang, G; Wan, J; Ye, D; Zhang, L, 2020) |
" As herbal preparations may interact with pharmaceutical drugs the following in vitro study was undertaken to determine whether the toxic effects of paracetamol on liver cell growth in culture would be exacerbated by the addition of psoralen, a furanocoumarin compound that is present in Psoralea corylifolia, a common Chinese herb." | 1.56 | Paracetamol (acetaminophen) hepatotoxicity increases in the presence of an added herbal compound. ( Britza, SM; Byard, RW; Musgrave, IF, 2020) |
"Acetaminophen (APAP)-induced acute liver failure (ALF) is a life-threatening disease with only a few treatment options available." | 1.51 | Liver-specific Bid silencing inhibits APAP-induced cell death in mice. ( Dames, S; Kuhla, A; Maxa, M; Schaeper, U; Vollmar, B, 2019) |
" Functional experiments showed that OPN deficiency protected against the APAP-induced liver injury by inhibiting the toxic APAP metabolism via reducing the expression of the cytochrome P450 family 2 subfamily E member 1 (CYP2E1)." | 1.51 | Metabolic modulation of acetaminophen-induced hepatotoxicity by osteopontin. ( Gu, J; Kong, X; Sun, X; Sun, Y; Tong, Y; Wang, C; Wang, K; Wen, Y; Wu, H; Xia, Q; Yu, C, 2019) |
"Acute liver failure is a serious consequence of acetaminophen (APAP)-induced hepatotoxic liver injury with high rates of morbidity and mortality." | 1.51 | The TGFβ1 Receptor Antagonist GW788388 Reduces JNK Activation and Protects Against Acetaminophen Hepatotoxicity in Mice. ( DeMorrow, S; Frampton, G; Grant, S; Jefferson, B; McMillin, M; Petrescu, AD; Williams, E, 2019) |
"Death commonly involved multiple substance use and abuse behaviours indicative of misuse and dependence." | 1.48 | Unintentional mortality associated with paracetamol and codeine preparations, with and without doxylamine, in Australia. ( Dobbin, M; Hopkins, RE; Pilgrim, JL, 2018) |
"Acetaminophen (APAP) is a readily available and safe painkiller." | 1.46 | Fast food diet-induced non-alcoholic fatty liver disease exerts early protective effect against acetaminophen intoxication in mice. ( Choi, D; Kim, JY; Kim, TH; Koo, SH; Lee, JH, 2017) |
"Hypoxic hepatitis is a clinical condition precipitated by prolonged periods of oxygen deprivation to the liver." | 1.46 | Plasma biomarkers to study mechanisms of liver injury in patients with hypoxic hepatitis. ( Antoine, DJ; Curry, SC; Jaeschke, H; Jenkins, RE; McGill, MR; Olson, JC; Sharpe, MR; Weemhoff, JL; Woolbright, BL, 2017) |
"In ConA-induced autoimmune hepatitis, RIP3 deletion was protective, whereas RIP1 inhibition exacerbated disease, accelerated animal death, and was associated with increased hepatocyte apoptosis." | 1.42 | Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury. ( Avanzi, N; Barilla, R; Daley, D; Deutsch, M; Eisenthal, A; Graffeo, CS; Greco, S; Gulati, R; Levie, EM; Miller, G; Ochi, A; Pachter, HL; Pansari, M; Rokosh, R; Tippens, DM; Tomkötter, L; Torres-Hernandez, A; Van Heerden, E; Zambirinis, CP, 2015) |
"Gap junctional intercellular communication (GJIC), by which glutathione (GSH) and inorganic ions are transmitted to neighboring cells, is recognized as being largely involved in toxic processes of chemicals." | 1.40 | Role of connexin 32 in acetaminophen toxicity in a knockout mice model. ( Arakawa, S; Igarashi, I; Kai, K; Maejima, T; Sanbuissho, A; Teranishi, M, 2014) |
"Curcumin was administered for 7 successive days, while paracetamol was administered at day six of treatment." | 1.40 | Immunohistochemical and molecular study on the protective effect of curcumin against hepatic toxicity induced by paracetamol in Wistar rats. ( Abdo Nassan, M; Ismail, TA; Soliman, MM, 2014) |
"APAP treatments caused necrosis in liver and accompanied by elevated liver PTX-3 levels after 48 h." | 1.39 | Pentraxin 3 as a potential biomarker of acetaminophen-induced liver injury. ( Agilli, M; Akgul, EO; Altinel, O; Aydin, FN; Aydin, I; Bilgi, C; Cakir, E; Cayci, T; Erbil, KM; Ersoz, N; Gulec, M; Isbilir, S; Kurt, YG; Onguru, O; Turker, T; Yaman, H; Yasar, M, 2013) |
"Irreversible acute liver failure, defined as rise in prothrombin time >3 times normal, occurred 19." | 1.39 | A reproducible, clinically relevant, intensively managed, pig model of acute liver failure for testing of therapies aimed to prolong survival. ( Alibhai, H; Baker, LA; Chang, YM; Davies, NA; Jalan, R; L Priestnall, S; Leckie, PJ; Lee, KC; Mookerjee, RP; Palacios Jimenez, C; Stanzani, G, 2013) |
"Acetaminophen (APAP) is a safe analgesic and antipyretic drug." | 1.38 | Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure. ( Amaral, SS; Avila, TV; Cara, DC; De Paula, AM; Leite, MF; Lima, BH; Lima, CX; Lopes, GA; Marques, PE; Melgaço, JG; Menezes, GB; Nogueira, LL; Oliveira, AG; Pinto, MA; Pires, DA; Russo, RC; Soriani, FM; Teixeira, MM, 2012) |
" Mkp-1⁺/⁺ and Mkp-1⁻/⁻ mice were dosed ip with vehicle or acetaminophen at 300 mg/kg (for mechanistic studies) or 400 mg/kg (for survival studies)." | 1.38 | Mitogen-activated protein kinase phosphatase (Mkp)-1 protects mice against acetaminophen-induced hepatic injury. ( Liu, Y; Meng, X; Rogers, LK; Wancket, LM, 2012) |
" Results show that rats administered with toxic doses (1000 mg/kg, 3000 mg/kg, 5000 mg/kg BW) of paracetamol exhibited significant increases in the levels of ALT, AST, γ- GT compared with controls." | 1.37 | Biochemical and histologic presentations of female Wistar rats administered with different doses of paracetamol/methionine. ( Adeniyi, FA; Iyanda, AA, 2011) |
" Erdosteine prevented APAP-induced liver injury and toxic side effects probably through the antioxidant and radical scavenging effects of erdosteine." | 1.35 | Effects of erdosteine on acetaminophen-induced hepatotoxicity in rats. ( Duru, M; Helvaci, R; Kaya, H; Koc, A; Kozlu, T; Kuvandik, G; Nacar, A; Sogüt, S; Yonden, Z, 2008) |
"Acetaminophen is a commonly used drug for the treatment of patients with common cold and influenza." | 1.35 | Phyllanthus urinaria extract attenuates acetaminophen induced hepatotoxicity: involvement of cytochrome P450 CYP2E1. ( Chan, AK; Chan, AS; Cheng, CH; Cheng, GY; Chui, CH; Fong, DW; Gambari, R; Hau, DK; Kan, CW; Kok, SH; Lai, PB; Lau, FY; Leung, AK; Tang, JC; Tong, CS; Wong, RS; Wong, WY; Yuen, MC; Zhu, GY, 2009) |
"Acetaminophen (APAP) is safe at therapeutic levels but causes hepatotoxicity via N-acetyl-p-benzoquinone imine-induced oxidative stress upon overdose." | 1.35 | Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity. ( Cheng, J; Gonzalez, FJ; Idle, JR; Krausz, KW; Ma, X, 2009) |
"However, acute renal failure, although less frequent, can lead to serious metabolic complications and require hemodialysis." | 1.35 | [Acute renal failure after acetaminophen poisoning: report of three cases]. ( Allaouchiche, B; Baillon, JJ; Ber, CE; Christin, F; Hayi-Slayman, D; Hengy, B; Page, M; Rimmelé, T, 2009) |
"Patient 1 was admitted with acute liver failure following acetaminophen intoxication." | 1.35 | Apoptosis versus necrosis rate as a predictor in acute liver failure following acetaminophen intoxication compared with acute-on-chronic liver failure. ( Bechmann, LP; Canbay, A; Gerken, G; Jochum, C; Marquitan, G; Saner, F, 2008) |
" The principal component analysis (PCA) of NMR or UPLC/MS spectra showed that metabolic changes observed in both acute and chronic dosing of acetaminophen were similar." | 1.35 | Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS. ( Beger, RD; Cantor, GH; Dragan, YP; Holland, RD; Schmitt, TC; Schnackenberg, LK; Sun, J, 2008) |
"Acetaminophen (APAP) is a widely used analgesic and antipyretic drug that is safe at therapeutic doses but which can precipitate liver injury at high doses." | 1.34 | Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury. ( Boelsterli, UA; Goh, CW; Latchoumycandane, C; Ong, MM, 2007) |
" The sensitivity of the proposed method to detect changes in the NMR spectra 24 and 48 h after single dosing was compared with histopathology and biochemical parameters in plasma and urine." | 1.34 | Sensitivity of (1)H NMR analysis of rat urine in relation to toxicometabonomics. Part I: dose-dependent toxic effects of bromobenzene and paracetamol. ( Horbach, GJ; Kloks, CP; Mellema, JR; Ploemen, JP; Schoonen, WG; Smit, MJ; Tas, AC; van Nesselrooij, JH; Vogels, JT; Zandberg, P; Zuylen, CT, 2007) |
"Carbon tetrachloride treatment 24 h prior to a challenging dose of carbon tetrachloride or acetaminophen decreased the resulting hepatotoxicity both in male and female mice as determined by histopathological examination and increases in serum enzyme activities." | 1.34 | Hepatic injury induces contrasting response in liver and kidney to chemicals that are metabolically activated: role of male sex hormone. ( Jung, YS; Kim, SY; Kim, YC; Park, JH; Yim, HK, 2007) |
"L-carnitine is a cofactor in the transfer of long-chain fatty acid allowing the beta-oxidation of fatty acid in the mitochondria." | 1.34 | Hepatoprotective effect of L-carnitine against acute acetaminophen toxicity in mice. ( Atakisi, O; Citil, M; Erginsoy, S; Karapehlivan, M; Kart, A; Tunca, R; Yapar, K, 2007) |
" To determine the importance of reversible versus toxic events, N-acetylcysteine (NAC) was administered to mice either before APAP or 1, 2, or 4 h after APAP." | 1.32 | Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation. ( Hinson, JA; James, LP; Lamps, LW; McCullough, SS, 2003) |
"Acetaminophen treatment of HepG2 cells caused oxidative damage and apoptosis." | 1.32 | N-acetylcysteine does not protect HepG2 cells against acetaminophen-induced apoptosis. ( Hirsh, M; Iancu, TC; Manov, I, 2004) |
"Acetaminophen (paracetamol) is an analgesic-antipyretic drug virtually devoid of typical anti-inflammatory activity and hence free of some of the side-effects of aspirin and related agents (e." | 1.32 | Long-term acetaminophen (paracetamol) treatment causes liver and kidney ultra-structural changes during rat pregnancy. ( Kulay, L; Neto, JA; Oliveira-Filho, RM; Simões, MJ; Soares, JM, 2004) |
"To understand the bioavailability and mechanistic pathways of cytoprotection by IH636 grape seed proanthocyanidin extract (GSPE, commercially known as ActiVin) a series of in vitro and in vivo studies were conducted." | 1.31 | Mechanistic pathways of antioxidant cytoprotection by a novel IH636 grape seed proanthocyanidin extract. ( Bagchi, D; Bagchi, M; Preuss, HG; Ray, SD; Stohs, SJ, 2002) |
"Liver necrosis was produced by administering single dose of paracetamol (2 g/kg, p." | 1.31 | Effect of Azadirachta indica (Neem) leaf aqueous extract on paracetamol-induced liver damage in rats. ( Bhanwra, S; Khosla, P; Singh, J, 2000) |
"Taurine (200 mg/kg) was given 12 h before, at the time of, and 1 or 2 h after acetaminophen injection." | 1.31 | Role of taurine in preventing acetaminophen-induced hepatic injury in the rat. ( Bouchier-Hayes, D; Kay, E; Redmond, HP; Wang, JH; Waters, E; Wu, QD, 2001) |
" In conclusion, the administration of 4-MP and/or NAC after 4 h of administering toxic dose of acetaminophen, inhibits hepatotoxicity in rats." | 1.31 | Comparison of the therapeutic efficacy of 4-methylpyrazole and N-acetylcysteine on acetaminophen (paracetamol) hepatotoxicity in rats. ( Acar, HV; Cankir, Z; Cermik, H; Cinan, U; Danaci, M; Küçükardali, Y; Nalbant, S; Ozkan, S; Top, C, 2002) |
" Thus, the protection against APAP toxicity afforded by deletion of both CYP2E1 and CYP1A2 likely reflects greatly diminished production of the toxic electrophile, NAPQI." | 1.30 | Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice. ( Bruno, MK; Buters, JT; Cohen, SD; Gonzalez, FJ; Lucas, AM; Stern, ST; Ward, JM; Zaher, H, 1998) |
"Acetaminophen (APAP) is a common analgesic and antipyretic compound which, when administered in high doses, has been associated with significant morbidity and mortality, secondary to hepatic toxicity." | 1.30 | Role of neutrophils in hepatotoxicity induced by oral acetaminophen administration in rats. ( Kokoska, ER; Miller, TA; Nadig, DE; Smith, GS; Solomon, H; Tiniakos, DG, 1998) |
"Hypothyroidism was induced by methimazole, propylthiouracil, or surgical thyroidectomy and confirmed by elevated serum levels of TSH." | 1.30 | Hypothyroidism protects rat liver from acetaminophen hepatotoxicity. ( Aeed, H; Avni, Y; Bruck, R; Frenkel, D; Halpern, Z; Matas, Z; Oren, R; Papa, M; Shirin, H; Zaidel, L, 1999) |
"Rats treated with misoprostol before and after APAP administration showed reduced OCT and ALT levels at 36 hr of overdose (454 +/- 446 IU/liter and 2571 +/- 2944 IU/liter, respectively) compared to those without misoprostol treatment (1348 +/- 480 IU/liter and 6077 +/- 3025 IU/liter, respectively, P < 0." | 1.29 | Misoprostol protection against acetaminophen-induced hepatotoxicity in the rat. ( Andrews, FJ; Lim, SP; O'Brien, PE, 1994) |
" Second, dose-response relationships for phenylpropanolamine and acetaminophen were such that increased toxicity was observed only when the interaction was sufficient to lower hepatic glutathione concentrations below a level regarded as critical in preventing acetaminophen-induced hepatotoxicity." | 1.29 | Phenylpropanolamine potentiation of acetaminophen-induced hepatotoxicity: evidence for a glutathione-dependent mechanism. ( Harbison, RD; James, RC; Roberts, SM, 1993) |
"The necrosis is probably multifactorial in origin, with ischaemia and sepsis contributing factors." | 1.28 | Necrotizing myopathy in critically-ill patients. ( Bone, JM; Campbell, IT; Coakley, JH; Green, CJ; Griffiths, RD; Helliwell, TR; McClelland, P; Wagenmakers, AJ, 1991) |
"The hepatotoxicity of acetaminophen (APAP) overdose depends on metabolic activation to a toxic reactive metabolite via hepatic mixed function oxidase." | 1.28 | Acetaminophen hepatotoxicity: is there a role for prostaglandin synthesis? ( Ben-Zvi, Z; Danon, A; Katz, S; Weissman-Teitellman, B, 1990) |
"Using weanling mice of two different genetic strains we demonstrated a potentiation of the toxic effects of acetaminophen by prior infection with influenza B virus." | 1.27 | Potentiation of the toxic effects of acetaminophen in mice by concurrent infection with influenza B virus: a possible mechanism for human Reye's syndrome? ( Hudak, G; MacDonald, MG; McGrath, PP; McMartin, DN; Washington, GC, 1984) |
"This augmented necrosis is averted by prolonged treatment with hyperbaric oxygen." | 1.27 | Effect of hyperoxia on liver necrosis induced by hepatotoxins. ( Marzella, L; Muhvich, K; Myers, RA, 1986) |
" Oral dosage of the 3,5-dialkyl-substituted derivatives up to 6." | 1.27 | Paracetamol, 3-monoalkyl- and 3,5-dialkyl derivatives: comparison of their hepatotoxicity in mice. ( de Vries, J; Groot, EJ; van de Straat, R; Vermeulen, NP; Zijl, R, 1987) |
" The operative status of the hepatic GSH conjugative system has an important influence on the rate of elimination of toxic APAP doses." | 1.27 | Time development of distribution and toxicity following single toxic APAP doses in male BOM:NMRI mice. ( Ingebrigtsen, K; Jansen, JH; Nafstad, I; Skoglund, LA, 1987) |
" Since the major nontoxic pathway (glucuronide) and the toxic pathway (as measured by mercapturate) decreased to a similar extent, the data indicate that the anomalous lack of protection cannot be explained on the basis of altered metabolic disposition of the drug." | 1.27 | Anomalous susceptibility of the fasted hamster to acetaminophen hepatotoxicity. ( Jollow, DJ; Miller, MG; Price, VF, 1986) |
" The depression of the nontoxic glucuronidation and sulfation pathways resulted in an increased proportion of the dose converted to the toxic metabolite and, hence, contributed to the potentiation of liver injury in fasted rats." | 1.27 | Mechanisms of fasting-induced potentiation of acetaminophen hepatotoxicity in the rat. ( Jollow, DJ; Miller, MG; Price, VF, 1987) |
" Since cysteamine decreased both beta and the apparent rate constant for mercapturate formation (K'MA), the proportion of the dose of acetaminophen which is converted to the toxic metabolite (K'MA/beta) was not significantly decreased in the presence of cysteamine." | 1.27 | Acetaminophen hepatotoxicity: studies on the mechanism of cysteamine protection. ( Jollow, DJ; Miller, MG, 1986) |
" These data cannot support the concept that induction of cytochrome P-450 leads to greater formation of the hypothetical toxic metabolite of acetaminophen, or that induction enhances its hepatotoxicity, in the rat." | 1.27 | Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat. ( Lerche, A; Pedersen, NT; Poulsen, HE, 1985) |
"Four caffeine-treated rats had histologic evidence of acute myocardial infarction which was not found in any of the other rats." | 1.26 | Cardiovascular lesions in Sprague-Dawley rats induced by long-term treatment with caffeine. ( Johansson, S, 1981) |
" A significant reduction in the LD50 was seen in the alcohol-pretreated mice, and correlations were noted between histological findings in the liver and the LD50 data." | 1.26 | Potentiation of acetaminophen hepatotoxicity by alcohol. ( Holtzman, JL; Kromhout, JP; McClain, CJ; Peterson, FJ, 1980) |
"Metyrapone was effective in preventing death when given up to 2 h after acetaminophen administration." | 1.26 | Effectiveness of methyrapone in the treatment of acetaminophen toxicity in mice. ( Goldstein, M; Montes, M; Nelson, EB, 1980) |
" The hallmark of severe (grade III) damage is centrizonal necrosis, for which there is probably a dosage threshold." | 1.26 | Evaluation of paracetamol-induced damage in liver biopsies. Acute changes and follow-up findings. ( Douglas, AP; Hamlyn, AN; James, OF; Lesna, M; Watson, AJ, 1976) |
" The plasma half-life of the unchanged drug was significantly prolonged, and the ratio of the plasma concentrations of unchanged to conjugated paracetamol was significantly higher than in the patients without liver damage." | 1.25 | The effects of hepatic and renal damage on paracetamol metabolism and excretion following overdosage. A pharmacokinetic study. ( Prescott, LF; Wright, N, 1973) |
Research
Studies (423)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 145 (34.28) | 18.7374 |
1990's | 53 (12.53) | 18.2507 |
2000's | 84 (19.86) | 29.6817 |
2010's | 110 (26.00) | 24.3611 |
2020's | 31 (7.33) | 2.80 |
Authors
Authors | Studies |
---|---|
Marques, PE | 2 |
Vandendriessche, S | 1 |
de Oliveira, THC | 1 |
Crijns, H | 1 |
Lopes, ME | 2 |
Blanter, M | 1 |
Schuermans, S | 1 |
Yu, K | 1 |
Poosti, F | 1 |
Vanheule, V | 1 |
Janssens, R | 1 |
Boff, D | 1 |
Kungl, AJ | 1 |
Menezes, GB | 3 |
Teixeira, MM | 2 |
Proost, P | 1 |
Chen, S | 1 |
Tang, Y | 2 |
Fang, W | 1 |
He, T | 1 |
Chen, X | 2 |
Zhang, P | 1 |
Cai, X | 1 |
Cai, H | 1 |
Wang, J | 3 |
Yang, Q | 1 |
Guan, J | 1 |
Deng, J | 1 |
Chen, Z | 1 |
Chen, D | 1 |
Zhao, X | 1 |
Xu, H | 1 |
Ren, H | 1 |
Liu, T | 1 |
Wang, Y | 4 |
Yang, D | 1 |
Yang, Z | 1 |
Nguyen, NT | 3 |
Umbaugh, DS | 2 |
Huang, EL | 1 |
Adelusi, OB | 2 |
Sanchez Guerrero, G | 1 |
Ramachandran, A | 14 |
Jaeschke, H | 34 |
Mao, X | 1 |
Wu, D | 1 |
Xu, N | 1 |
Zeng, J | 1 |
Jiang, Z | 1 |
Liu, Y | 4 |
Liang, H | 1 |
Samuvel, DJ | 1 |
Lemasters, JJ | 7 |
Wang, X | 1 |
Choo, YM | 1 |
Hamann, MT | 1 |
Zhong, Z | 1 |
Nakagaki, BN | 1 |
Mattos, MS | 1 |
Campolina-Silva, GH | 1 |
Meira, RO | 1 |
Paixão, PHM | 1 |
Oliveira, AG | 2 |
Faustino, LD | 1 |
Gonçalves, R | 1 |
El-Kashef, DH | 1 |
Sharawy, MH | 1 |
Akakpo, JY | 1 |
Jaeschke, MW | 1 |
Etemadi, Y | 1 |
Artigues, A | 1 |
Toerber, S | 1 |
Olivos, H | 1 |
Shrestha, B | 1 |
Midey, A | 1 |
Win, S | 3 |
Than, TA | 2 |
Kaplowitz, N | 6 |
Cao, Y | 1 |
He, W | 2 |
Li, X | 2 |
Huang, J | 1 |
Alabbas, SY | 1 |
Giri, R | 1 |
Oancea, I | 1 |
Davies, J | 1 |
Schreibner, V | 1 |
Florin, TH | 1 |
Begun, J | 1 |
Smith, S | 1 |
Sanchez-Guerrero, G | 1 |
Ishida, Y | 1 |
Zhang, S | 1 |
Kuninaka, Y | 1 |
Ishigami, A | 1 |
Nosaka, M | 1 |
Harie, I | 1 |
Kimura, A | 1 |
Mukaida, N | 1 |
Kondo, T | 1 |
Gu, L | 1 |
He, X | 1 |
Zhang, Y | 2 |
Li, S | 1 |
Tang, J | 2 |
Ma, R | 1 |
Yang, X | 5 |
Huang, H | 1 |
Peng, Y | 1 |
Xie, Y | 4 |
Peng, Z | 1 |
Meng, J | 1 |
Hu, G | 1 |
Tao, L | 1 |
Liu, X | 1 |
Yang, H | 1 |
Yu, Y | 3 |
Zhou, S | 1 |
Di, S | 1 |
Huang, X | 1 |
Chen, Y | 3 |
Gayatri Devi, R | 1 |
Ezhilarasan, D | 2 |
Iacob, RE | 1 |
Iacob, D | 1 |
Moleriu, RD | 1 |
Tit, DM | 1 |
Bungau, S | 1 |
Otrisal, P | 1 |
Aleya, S | 1 |
Judea-Pusta, C | 1 |
Cioca, G | 1 |
Bratu, OG | 1 |
Aleya, L | 1 |
Petre, I | 1 |
Min, RW | 1 |
Chen, CQ | 1 |
Zhang, J | 1 |
Li, M | 3 |
Suzuki, A | 1 |
Abdelmalek, MF | 1 |
Aghajan, M | 1 |
Aung, FW | 1 |
Diehl, AM | 1 |
Davis, RJ | 1 |
Maxa, M | 1 |
Schaeper, U | 1 |
Dames, S | 1 |
Vollmar, B | 1 |
Kuhla, A | 1 |
Groeneveld, D | 1 |
Cline-Fedewa, H | 1 |
Baker, KS | 1 |
Williams, KJ | 1 |
Roth, RA | 3 |
Mittermeier, K | 1 |
Lisman, T | 2 |
Palumbo, JS | 1 |
Luyendyk, JP | 2 |
Hassan, R | 1 |
Minsart, C | 1 |
Liefferinckx, C | 1 |
Lemmers, A | 1 |
Dressen, C | 1 |
Quertinmont, E | 1 |
Leclercq, I | 1 |
Devière, J | 1 |
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Clinical Trials (4)
Trial Overview
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Randomized, Double-blind, Placebo-controlled, Multi-site, Phase III Study to Evaluate the Safety and Efficacy of CD24Fc in COVID-19 Treatment[NCT04317040] | Phase 3 | 234 participants (Actual) | Interventional | 2020-04-24 | Completed | ||
Evaluating the Effects of Acupuncture in the Treatment of Taxane Induces Peripheral Neuropathy (TIPN)[NCT02831114] | 18 participants (Actual) | Interventional | 2016-05-31 | Completed | |||
[NCT00799578] | Phase 1/Phase 2 | 13 participants (Actual) | Interventional | 2008-10-31 | Completed | ||
A Full-Factorial, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Single-Dose Efficacy and Safety Study of an Acetaminophen/Naproxen Sodium Fixed Combination, Acetaminophen, and Naproxen Sodium in Postoperative Dental Pain[NCT05761574] | Phase 3 | 440 participants (Anticipated) | Interventional | 2023-05-22 | Recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Trial Outcomes
Duration of ECMO
Duration of ECMO treatment (days) was calculated as: End Date of ECMO Treatment - Start Date of ECMO Treatment + 1 and reported. (NCT04317040)
Timeframe: Up to Day 29
Intervention | Days (Mean) |
---|---|
Placebo | 11.0 |
Duration of High Flow Oxygen Therapy
Duration of oxygen therapy (oxygen inhalation by high flow nasal cannula or mask) (days) was calculated as: End Date of high flow oxygen therapy - Start Date of high flow oxygen therapy + 1 and reported. (NCT04317040)
Timeframe: Up to Day 29
Intervention | Days (Mean) |
---|---|
CD24Fc | 13.8 |
Placebo | 13.0 |
Duration of MV
MV included IMV and NIV. Duration of MV (days) was calculated as: End Date of MV - Start Date of MV + 1 and reported. (NCT04317040)
Timeframe: Up to Day 29
Intervention | Days (Mean) |
---|---|
CD24Fc | 14.3 |
Placebo | 14.3 |
Duration of Pressors
Pressor administration included norepinephrine, epinephrine, vasopressin, dopamine and phenylephrine. Duration of pressor (days) was defined as: End Date of Pressor - Start Date of Pressor + 1 and reported. (NCT04317040)
Timeframe: Up to Day 29
Intervention | Days (Mean) |
---|---|
CD24Fc | 6.3 |
Placebo | 7.9 |
Length of Hospital Stay
Length of Hospital Stay (Days) was defined as date of discharge - date of admission + 1 and reported. Data presented below include hospitalization time prior to enrollment in the study with total duration of up to 90 days. (NCT04317040)
Timeframe: Up to 90 days
Intervention | Days (Mean) |
---|---|
CD24Fc | 16.6 |
Placebo | 18.2 |
Number of Participants Who Experience an Adverse Event (AE)
An AE was defined as any unfavorable and unintended sign including an abnormal laboratory finding, symptom or disease associated with the use of a medical treatment or procedure, regardless of whether it is considered related to the medical treatment or procedure, that occurs during the course of the study. Per protocol, only AEs with Common Terminology Criteria for AE (CTACAE) grade ≥3 were included. The number of participants who experienced an AE were reported. (NCT04317040)
Timeframe: Up to 30 days
Intervention | Participants (Count of Participants) |
---|---|
CD24Fc | 32 |
Placebo | 35 |
Percentage of Participants Who Died or Had Respiratory Failure (RF)
RF was defined as the need for any of the following: 1) mechanical ventilation (MV), 2) ECMO, 3) NIV, or 4) high flow oxygen devices. Percentage of participants who died or had respiratory failure by Day 29 were reported. (NCT04317040)
Timeframe: Up to Day 29
Intervention | Percentage of Participants (Number) |
---|---|
CD24Fc | 22.4 |
Placebo | 28.0 |
Rate of Clinical Relapse
Rate of clinical relapse was defined as the percentage of participants who had initially reached score 5 on NIAID ordinal scale for more than one day but subsequently became dependent on oxygen support for more than 1 day within 28 days from randomization after initial recovery with a total follow-up period of 29 days (Day 1 of randomization plus 28 days of follow-up). NIAID ordinal scale graded as: 1=Death; 2=Hospitalized, on IMV/ECMO; 3=Hospitalized, on NIV/high flow oxygen devices; 4= Hospitalized, require supplemental oxygen; 5=Hospitalized, no supplemental oxygen, require medical care; 6=Hospitalized, no supplemental oxygen, do not require medical care; 7=Not hospitalized, limitation on activities and/or require home oxygen; 8=Not hospitalized, no limitations on activities. Clopper-Pearson method was used to report the 95% CI. (NCT04317040)
Timeframe: Up to Day 29
Intervention | Percentage of Participants (Number) |
---|---|
CD24Fc | 4.3 |
Placebo | 6.8 |
Time to Disease Progression in Clinical Status of COVID-19
Time to disease progression in clinical status is defined as the time (days) for progression from NIAID score (3 or 4) to (2 or 1) or from 2 to 1 within 28 days from randomization, total follow-up period 29 days (Randomization Day 1 + 28 days follow up). NIAID ordinal scale graded as: 1=Death; 2=Hospitalized, on IMV/ECMO; 3=Hospitalized, on NIV/high flow oxygen devices; 4= Hospitalized, require supplemental oxygen; 5=Hospitalized, no supplemental oxygen, require medical care; 6=Hospitalized, no supplemental oxygen, do not require medical care; 7=Not Hospitalized, limitation on activities and/or require home oxygen; 8=Not hospitalized, no limitations on activities. (NCT04317040)
Timeframe: Up to Day 29
Intervention | Days (Median) |
---|---|
CD24Fc | NA |
Placebo | NA |
Time to Hospital Discharge
The hospital discharge time was defined as the time from randomization to discharge from the hospital and reported. Time to Hospital Discharge (days) from randomization is calculated as: Time to hospital discharge = Date of hospital discharge - Date of randomization. (NCT04317040)
Timeframe: Up to Day 29
Intervention | Days (Median) |
---|---|
CD24Fc | 7.0 |
Placebo | 10.5 |
Time to Improvement in Coronavirus Disease 2019 (COVID-19) Clinical Status
Time to improvement in COVID-19 clinical status: defined as time (days) required from start of treatment to improvement of clinical status severe - moderate/mild or improvement from score 2-4 to ≥5 sustained without drop below 5 within 28 days from randomization, total follow-up period 29 days (Randomization Day 1 + 28 days follow up) per National Institute of Allergy & Infectious Diseases (NIAID) ordinal scale graded: 1=Death; 2=Hospitalized, on invasive mechanical ventilation (IMV)/extracorporeal membrane oxygenation (ECMO); 3=Hospitalized, on non-invasive ventilation (NIV)/high flow oxygen devices; 4=Hospitalized, require supplemental oxygen; 5=Hospitalized, no supplemental oxygen, require medical care; 6=Hospitalized, no supplemental oxygen, don't require medical care; 7=Not hospitalized, limitation on activities &/or require home oxygen; 8=Not hospitalized, no limitations on activities. Median time & 95% confidence intervals (CIs) were reported using Brookmeyer-Crowley method. (NCT04317040)
Timeframe: Up to Day 29
Intervention | Days (Median) |
---|---|
CD24Fc | 6.0 |
Placebo | 10.5 |
Change From Baseline in Absolute Lymphocyte Count
Blood samples were collected to present the change from baseline in the absolute lymphocyte count on days 1, 4, 8, and 15 in peripheral blood. To calculate the change from baseline in absolute lymphocyte count at specific timepoints (Days 1, 4, 8 and 15), only the participants who had both, a baseline, and a post baseline value at the specific timepoint (Days 1, 4, 8 and 15) were included in the analysis. (NCT04317040)
Timeframe: Baseline and up to Day 15
Intervention | 10^9 Cells/Liter (Mean) | ||||||||
---|---|---|---|---|---|---|---|---|---|
Baseline | Day 1 | Day 4 | Day 8 | Day 15 | Change from Baseline to Day 1 | Change from Baseline to Day 4 | Change from Baseline to Day 8 | Change from Baseline to Day 15 | |
CD24Fc | 2.357 | 5.317 | 2.373 | 2.557 | 1.965 | 0.374 | 0.219 | 0.575 | 0.558 |
Placebo | 2.437 | 5.125 | 2.461 | 1.839 | 2.378 | -0.148 | 0.053 | -0.491 | -0.280 |
Change From Baseline in D-Dimer Concentration
Blood samples were collected to present the change from baseline in the D-dimer concentration on days 4, 8 and 15 in peripheral blood. To calculate change from baseline in D-dimer concentration at specific timepoints (Days 4, 8 and 15), only the participants who had both, a baseline, and a post baseline value at the specific timepoint (Days 4, 8 and 15) were included in the analysis. (NCT04317040)
Timeframe: Baseline and up to Day 15
Intervention | nmol/Liter (Mean) | ||||||
---|---|---|---|---|---|---|---|
Baseline | Day 4 | Day 8 | Day 15 | Change from Baseline to Day 4 | Change from Baseline to Day 8 | Change from Baseline to Day 15 | |
CD24Fc | 153.717 | 10.451 | 13.224 | 11.700 | -0.427 | -397.547 | 3.076 |
Placebo | 9.767 | 13.885 | 13.349 | 13.892 | 3.971 | 0.703 | -3.591 |
Conversion Rate of COVID-19 Clinical Status
Conversion rate of COVID-19 clinical status on days 8 and 15 was defined as the percentage of participants who changed from NIAID ordinal score 2, 3, 4 to score 5 or higher and reported. NIAID ordinal scale graded as: 1=Death; 2=Hospitalized, on IMV/ECMO; 3=Hospitalized, on NIV/high flow oxygen devices; 4= Hospitalized, require supplemental oxygen; 5=Hospitalized, no supplemental oxygen, require medical care; 6=Hospitalized, no supplemental oxygen, do not require medical care; 7=Not hospitalized, limitation on activities and/or require home oxygen; 8=Not hospitalized, no limitations on activities. (NCT04317040)
Timeframe: Up to Day 15
Intervention | Percentage of participants (Number) | |
---|---|---|
Day 8 | Day 15 | |
CD24Fc | 55.2 | 71.6 |
Placebo | 42.4 | 55.9 |
Number of Participants Who Died Due to Any Cause
Number of participants who died due to any cause were assessed per protocol on Day 15 and Day 29. (NCT04317040)
Timeframe: Up to Day 29
Intervention | Participants (Count of Participants) | |
---|---|---|
Day 15 | Day 29 | |
CD24Fc | 11 | 16 |
Placebo | 8 | 18 |
Normalization or >50% of Serum ALT Levels From Baseline
(NCT00799578)
Timeframe: 6 months
Intervention | participants (Number) |
---|---|
Number of Improved Subjects | 7 |
Reviews
27 reviews available for acetaminophen and Necrosis
Article | Year |
---|---|
Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Chemical a | 2022 |
Platanosides, a Potential Botanical Drug Combination, Decrease Liver Injury Caused by Acetaminophen Overdose in Mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Combinations; Glycosides; Kelch | 2022 |
Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemokines; Cytokines; DNA Fragmenta | 2020 |
Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver.
Topics: Acetaminophen; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Humans; Mitochondria; Nec | 2013 |
Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study.
Topics: Acetaminophen; Adult; Carcinoma, Hepatocellular; Disease Progression; Drug Therapy, Combination; Enz | 2014 |
Mechanisms of acetaminophen-induced liver necrosis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biotransformation; Chemical and Drug Induced Liver | 2010 |
Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Biological Products; Cell Death; Diseas | 2011 |
Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity.
Topics: Acetaminophen; Animals; Autoimmunity; Chemical and Drug Induced Liver Injury; Hepatocytes; Humans; I | 2012 |
Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antioxidants; Apoptosis; Cell Death; Chemical and Drug Indu | 2012 |
The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Adenosine Triphosphate; Analgesics, Non-Narcotic; Animals; Apoptosis; Humans; Lipid P | 2003 |
Intracellular signaling mechanisms of acetaminophen-induced liver cell death.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Apoptosis; Cell Death; DNA Fragmentation; Hepatocytes; Live | 2006 |
Apoptosis and necrosis in the liver: a tale of two deaths?
Topics: Acetaminophen; Animals; Apoptosis; Apoptosis Regulatory Proteins; Caspases; Cholestasis, Intrahepati | 2006 |
The treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Antidotes; Aspartate Aminotransferases; Biotran | 1983 |
Drug induced liver disease.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Necrosis | 1983 |
Acetaminophen hepatotoxicity.
Topics: Acetaminophen; Adult; Aged; Alcoholism; Chemical and Drug Induced Liver Injury; Chemical Phenomena; | 1984 |
Mechanisms of cell injury with hepatotoxic chemicals.
Topics: Acetaminophen; Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Che | 1984 |
[Paracetamol: overdose and hepatic lesions].
Topics: Acetaminophen; Aspirin; Chemical and Drug Induced Liver Injury; Fever; Humans; Liver; Necrosis; Pain | 1981 |
Acetaminophen/aspirin mixtures: experimental data.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1996 |
Drug metabolism in the production of liver injury.
Topics: Acetaminophen; Acetanilides; Alkylating Agents; Bromobenzenes; Chemical and Drug Induced Liver Injur | 1975 |
The third Lilly Prize Lecture. University of London, January, 1979. The nephrotoxicity and hepatotoxicity of antipyretic analgesics.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induced Liver Inj | 1979 |
Metabolic activation: biochemical basis for many drug-induced liver injuries.
Topics: Acetaminophen; Animals; Binding Sites; Carcinogens; Chemical and Drug Induced Liver Injury; Drug Hyp | 1976 |
Acute liver injury.
Topics: Acetaminophen; Acute Disease; Chemical and Drug Induced Liver Injury; Cholestasis; Halothane; Hepati | 1975 |
Drug-induced hepatotoxicity.
Topics: Acetaminophen; Bile; Bile Acids and Salts; Biotransformation; Cell Survival; Chemical and Drug Induc | 1986 |
Chlorzoxazone hepatotoxic reactions. An analysis of 21 identified or presumed cases.
Topics: Acetaminophen; Adult; Aged; Benzoxazoles; Biopsy; Chlorzoxazone; Drug Combinations; Drug Evaluation; | 1986 |
Protective agents for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Animals; Cell Membrane; Chemical and Drug Induced Liver Injury; Cimet | 1986 |
The biochemical pathology of toxic cell death.
Topics: Acetaminophen; Animals; Biotransformation; Calcium; Carbon Tetrachloride; Cell Membrane; Cell Membra | 1985 |
Acute hepatic necrosis and fulminant hepatic failure.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Animals; Blood Coagulation Disorders; Brain Dise | 1973 |
Trials
3 trials available for acetaminophen and Necrosis
Article | Year |
---|---|
Drug therapy. Acetaminophen.
Topics: Acetaminophen; Adolescent; Adult; Aspirin; Body Temperature; Chemical and Drug Induced Liver Injury; | 1976 |
Reduction of absorption of paracetamol by activated charcoal and cholestyramine: a possible therapeutic measure.
Topics: Acetaminophen; Administration, Oral; Charcoal; Chemical and Drug Induced Liver Injury; Cholestyramin | 1973 |
A controlled trial of heparin therapy in the coagulation defect of paracetamol-induced hepatic necrosis.
Topics: Acetaminophen; Adolescent; Adult; Blood Coagulation Disorders; Blood Transfusion; Chemical and Drug | 1974 |
Other Studies
393 other studies available for acetaminophen and Necrosis
Article | Year |
---|---|
Inhibition of Drug-Induced Liver Injury in Mice Using a Positively Charged Peptide That Binds DNA.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Chemokine | 2021 |
CoQ10 Promotes Resolution of Necrosis and Liver Regeneration After Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2021 |
Noninvasive Assessment of APAP (N-acetyl-p-aminophenol)-Induced Hepatotoxicity Using Multiple MRI Parameters in an Experimental Rat Model.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Contrast Media; Diffusion Magnetic R | 2022 |
Recovered Hepatocytes Promote Macrophage Apoptosis Through CXCR4 After Acetaminophen-Induced Liver Injury in Mice.
Topics: Acetaminophen; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced | 2022 |
The danger signal interferon-induced protein 35 (IFP35) mediates acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Interferons; Intracellular Signaling | 2022 |
Susceptibility to Infections During Acute Liver Injury Depends on Transient Disruption of Liver Macrophage Niche.
Topics: Acetaminophen; Humans; Kupffer Cells; Liver; Macrophages; Monocytes; Necrosis | 2022 |
Hepatoprotective effect of nicorandil against acetaminophen-induced oxidative stress and hepatotoxicity in mice via modulating NO synthesis.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Liver; Mice; Necrosis; | 2023 |
Desorption Electrospray Ionization Mass Spectrometry Imaging Allows Spatial Localization of Changes in Acetaminophen Metabolism in the Liver after Intervention with 4-Methylpyrazole.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Fomepizole; Humans; Liver; Mice; Mic | 2022 |
c-
Topics: Acetaminophen; Animals; Catalytic Domain; Chemical and Drug Induced Liver Injury; Glutamate-Cysteine | 2023 |
Rosiglitazone Protects against Acetaminophen-Induced Acute Liver Injury by Inhibiting Multiple Endoplasmic Reticulum Stress Pathways.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Chaperone BiP; | 2022 |
Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Homeodomain Proteins; Inflammation; | 2023 |
Dose-dependent pleiotropic role of neutrophils during acetaminophen-induced liver injury in male and female mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju | 2023 |
Essential Involvement of Neutrophil Elastase in Acute Acetaminophen Hepatotoxicity Using BALB/c Mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Leukocyte Elastase; Liver Diseases; | 2023 |
Fluorofenidone protects against acute liver failure in mice by regulating MKK4/JNK pathway.
Topics: Acetaminophen; Animals; Anisomycin; Hepatocytes; Lipopolysaccharides; Liver; Liver Failure, Acute; M | 2023 |
Leonurine alleviates acetaminophen-induced acute liver injury by regulating the PI3K/AKT signaling pathway in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Inflammation; Liver; Mice; Molecular | 2023 |
Concurrent administration of farnesol protects acetaminophen-induced acute hepatic necrosis in mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Chemical and Drug Induce | 2023 |
Consequences of analgesics use in early pregnancy: Results of tests on mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Female; Ki | 2019 |
Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury.
Topics: Acetaminophen; Animals; Apoptosis; Cell Death; Chemical and Drug Induced Liver Injury; Estrogen Rece | 2019 |
Liver-specific Bid silencing inhibits APAP-induced cell death in mice.
Topics: Acetaminophen; Animals; Apoptosis; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist | 2019 |
Von Willebrand factor delays liver repair after acetaminophen-induced acute liver injury in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Blood Coagulation; Blood Platelets; Chemical and D | 2020 |
Acetaminophen induces programmed necrosis.
Topics: Acetaminophen; Apoptosis; Cell Death; Chemical and Drug Induced Liver Injury, Chronic; Humans; Liver | 2019 |
New insights in acetaminophen toxicity: HMGB1 contributes by itself to amplify hepatocyte necrosis in vitro through the TLR4-TRIF-RIPK3 axis.
Topics: Acetaminophen; Adaptor Proteins, Vesicular Transport; Cell Line; Cell Line, Tumor; Cells, Cultured; | 2020 |
Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via upregulation of heme oxygenase-1 expression.
Topics: Acetaminophen; Animals; Apoptosis; Cell Death; Cell Line; Chemical and Drug Induced Liver Injury; Do | 2020 |
Mitochondrial depolarization and repolarization in the early stages of acetaminophen hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2020 |
Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Co | 2020 |
Paracetamol (acetaminophen) hepatotoxicity increases in the presence of an added herbal compound.
Topics: Acetaminophen; Cell Death; Chemical and Drug Induced Liver Injury; Drug Synergism; Ficusin; Hep G2 C | 2020 |
Ecto-Nucleotide Triphosphate Diphosphohydrolase-2 (NTPDase2) Deletion Increases Acetaminophen-Induced Hepatotoxicity.
Topics: Acetaminophen; Adenosine Triphosphatases; Alanine Transaminase; Alkaline Phosphatase; Animals; Chemi | 2020 |
A computational model of liver tissue damage and repair.
Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Cell Prolifera | 2020 |
Boldine treatment protects acetaminophen-induced liver inflammation and acute hepatic necrosis in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Aporphines; Chemical and Drug Induced Liver Injury; Cytokine | 2021 |
Protective effects of resveratrol and avocado oil against paracetamol-induced hepatotoxicity in rats.
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Liver; Necrosis; Oxida | 2022 |
AST/ALT levels, MDA, and liver histopathology of
Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Liver; Liver Diseases; | 2021 |
Fast food diet-induced non-alcoholic fatty liver disease exerts early protective effect against acetaminophen intoxication in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 2017 |
Unintentional mortality associated with paracetamol and codeine preparations, with and without doxylamine, in Australia.
Topics: Accidents; Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Antiemetics; Austr | 2018 |
Effects of metamizole, MAA, and paracetamol on proliferation, apoptosis, and necrosis in the pancreatic cancer cell lines PaTu 8988 t and Panc-1.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Age | 2017 |
Silymarin prevents acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Liver; Male; Mice; Mi | 2018 |
The beneficial effects of ozone therapy in acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical an | 2018 |
Exogenous recombinant human thioredoxin-1 prevents acetaminophen-induced liver injury by scavenging oxidative stressors, restoring the thioredoxin-1 system and inhibiting receptor interacting protein-3 overexpression.
Topics: Acetaminophen; Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Cytoprotect | 2018 |
Metabolic modulation of acetaminophen-induced hepatotoxicity by osteopontin.
Topics: Acetaminophen; Animals; Apoptosis; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytochro | 2019 |
Inhibition of acetaminophen-induced hepatotoxicity in mice by exogenous thymosinβ4 treatment.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Autophagy; | 2018 |
Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury: possible involvement of ER stress and S6K1 activation.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Stress; Hepato | 2019 |
Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Antioxidants; Apoptosis; Caspase 3; Chemical and Drug Induce | 2019 |
Integrative proteomics and immunochemistry analysis of the factors in the necrosis and repair in acetaminophen-induced acute liver injury in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Hepatocytes; Immunochemistry; Liver; | 2019 |
Improved protective effects of American ginseng berry against acetaminophen-induced liver toxicity through TNF-α-mediated caspase-3/-8/-9 signaling pathways.
Topics: Acetaminophen; Alanine Transaminase; Aldehydes; Animals; Aspartate Aminotransferases; Caspases; Chem | 2018 |
Prevention of acetaminophen-induced liver injury by alginate.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Alginates; Analgesics, Non-Narcotic; Anim | 2019 |
The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling.
Topics: Acetaminophen; Animals; beta Catenin; Cell Proliferation; Chemical and Drug Induced Liver Injury; En | 2019 |
Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange.
Topics: Acetaminophen; Activation, Metabolic; Analgesics, Non-Narcotic; Animals; Cell Communication; Chemica | 2019 |
The TGFβ1 Receptor Antagonist GW788388 Reduces JNK Activation and Protects Against Acetaminophen Hepatotoxicity in Mice.
Topics: Acetaminophen; Animals; Antioxidants; Apoptosis; Benzamides; Cell Death; Chemical and Drug Induced L | 2019 |
Acetaminophen-induced liver injury is mediated by the ion channel TRPV4.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cells, Cultured; Chemical and Drug Induced Liver I | 2019 |
Cell-free DNA in blood circulation is generated by DNase1L3 and caspase-activated DNase.
Topics: Acetaminophen; Animals; Antibodies, Neutralizing; Cell-Free Nucleic Acids; Deoxyribonucleases; Endod | 2019 |
Tissue Necrosis and Fungal Rhinosinusitis Resulting From Intranasal Acetaminophen Use.
Topics: Acetaminophen; Administration, Intranasal; Adult; Female; Humans; Medical Illustration; Mycoses; Nas | 2020 |
Dichotomous Role of Plasmin in Regulation of Macrophage Function after Acetaminophen Overdose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Drug Overd | 2019 |
TAFI deficiency promotes liver damage in murine models of liver failure through defective down-regulation of hepatic inflammation.
Topics: Acetaminophen; Actins; Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Ca | 2013 |
The ameliorative effects of L-2-oxothiazolidine-4-carboxylate on acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Aldehydes; Analgesics, Non-Narcotic; Animals; Antioxidants; Apo | 2013 |
Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice.
Topics: Acetaminophen; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepa | 2013 |
Korean red ginseng extract prevents APAP-induced hepatotoxicity through metabolic enzyme regulation: the role of ginsenoside Rg3, a protopanaxadiol.
Topics: Acetaminophen; Animals; Gene Expression Regulation, Enzymologic; Ginsenosides; Lethal Dose 50; Liver | 2013 |
Protein kinase C (PKC) participates in acetaminophen hepatotoxicity through c-jun-N-terminal kinase (JNK)-dependent and -independent signaling pathways.
Topics: Acetaminophen; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Chemical and Drug Induced Li | 2014 |
Early detection of paracetamol toxicity using circulating liver microRNA and markers of cell necrosis.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Humans; Liver; Male; MicroRNAs; Necrosis | 2014 |
Hepatoprotective, antioxidant, and ameliorative effects of ginger (Zingiber officinale Roscoe) and vitamin E in acetaminophen treated rats.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants; Aspartate Amin | 2013 |
Anorectal necrosis after paracetamol abuse.
Topics: Acetaminophen; Adult; Anal Canal; Analgesics, Non-Narcotic; Back Pain; Female; Humans; Necrosis; Rec | 2014 |
Curcumin protects against acetaminophen-induced apoptosis in hepatic injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; B | 2013 |
Role of connexin 32 in acetaminophen toxicity in a knockout mice model.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Connexins; Dose-Response Relationshi | 2014 |
Role of receptor interacting protein (RIP)1 on apoptosis-inducing factor-mediated necroptosis during acetaminophen-evoked acute liver failure in mice.
Topics: Acetaminophen; Animals; Apoptosis Inducing Factor; Chemical and Drug Induced Liver Injury; Cytochrom | 2014 |
HMGB1 neutralization is associated with bacterial translocation during acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Bacterial Translocation; Chemical and Drug Induced | 2014 |
Therapeutic potential of different commercially available synbiotic on acetaminophen-induced uremic rats.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Urea Nitrogen; Cata | 2015 |
[Anorectal necrosis and paracetamol suppository abuse].
Topics: Acetaminophen; Adult; Anal Canal; Anti-Inflammatory Agents, Non-Steroidal; Drug Overdose; Female; Hu | 2014 |
Mechanisms of acetaminophen-induced cell death in primary human hepatocytes.
Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Analgesics, Non-Narcotic; Antidotes; Cell Death; Enzyme | 2014 |
Carbamoyl phosphate synthetase-1 is a rapid turnover biomarker in mouse and human acute liver injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; Biomarkers; Carbamoyl-Phosphate Synthase (A | 2014 |
Targeting mitochondria with methylene blue protects mice against acetaminophen-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Cell Death; Cells, Cultured; Chemic | 2015 |
Protective effect of artichoke leaf extract against paracetamol-induced hepatotoxicity in rats.
Topics: Acetaminophen; Animals; Antioxidants; Apoptosis; Biomarkers; Chemical and Drug Induced Liver Injury; | 2015 |
Immunohistochemical and molecular study on the protective effect of curcumin against hepatic toxicity induced by paracetamol in Wistar rats.
Topics: Acetaminophen; Acute-Phase Proteins; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and D | 2014 |
Pleurotus ostreatus opposes mitochondrial dysfunction and oxidative stress in acetaminophen-induced hepato-renal injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Biological | 2014 |
The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; fas Recept | 2015 |
Education and imaging. Hepatology: Rare Stevens-Johnson syndrome and vanishing bile duct syndrome induced by acetaminophen, requiring liver transplantation.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Bile Ducts, Intrahepatic; Cholestasis; Dilat | 2015 |
Early activated hepatic stellate cell-derived molecules reverse acute hepatic injury.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Cell Shape; Cells, Cultured; Chemical and Drug Ind | 2015 |
Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Chemical and Drug Induce | 2015 |
Protective effects of ethanolic extract of Nigella sativa seed in paracetamol induced acute hepatotoxicity in vivo.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Apoptosis; Asparta | 2014 |
Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury.
Topics: Acetaminophen; Animals; Apoptosis; Carrier Proteins; Caspase 8; Chemokine CCL2; Concanavalin A; Dise | 2015 |
Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis.
Topics: Acetaminophen; Animals; Apoptosis; Male; Mice; Mice, Inbred C57BL; Necrosis; Organelles; Protein Kin | 2015 |
Subcutaneous Injection of Percocet: A Case of Severe Soft Tissue Loss.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cellulitis; Debridement; Drug Combinations; Drug Eruptions; | 2015 |
Withaferin-A Reduces Acetaminophen-Induced Liver Injury in Mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Cell Line; Cell Survival; Chemical a | 2015 |
Loss of 5-lipoxygenase activity protects mice against paracetamol-induced liver toxicity.
Topics: Acetaminophen; Alanine Transaminase; Angiogenic Proteins; Animals; Aspartate Aminotransferases; Chem | 2016 |
The end of RIPK1-RIPK3-MLKL-mediated necroptosis in acetaminophen-induced hepatotoxicity?
Topics: Acetaminophen; Apoptosis; Chemical and Drug Induced Liver Injury; Humans; Necrosis; Receptor-Interac | 2016 |
Enhanced Production of Adenosine Triphosphate by Pharmacological Activation of Adenosine Monophosphate-Activated Protein Kinase Ameliorates Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; AMP-Activated Protein Kinases; Animals; | 2015 |
Comparative metabonomic analysis of hepatotoxicity induced by acetaminophen and its less toxic meta-isomer.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Biomarkers; Biotransformation; Che | 2016 |
Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices.
Topics: Acetaminophen; Aged; Benzofurans; Bile Acids and Salts; Chloramphenicol; Chlorpromazine; Cholestasis | 2016 |
Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury?
Topics: Acetaminophen; Adolescent; Adult; Aged; Animals; Chemical and Drug Induced Liver Injury; Child, Pres | 2016 |
Reducing Hepatocyte Injury and Necrosis in Response to Paracetamol Using Noncoding RNAs.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Female; Hepatocytes; Humans; Liver; Ma | 2016 |
Quercitrin from Toona sinensis (Juss.) M.Roem. Attenuates Acetaminophen-Induced Acute Liver Toxicity in HepG2 Cells and Mice through Induction of Antioxidant Machinery and Inhibition of Inflammation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxida | 2016 |
Plasma biomarkers to study mechanisms of liver injury in patients with hypoxic hepatitis.
Topics: Acetaminophen; Adolescent; Adult; Alanine Transaminase; Apoptosis; Biomarkers; DNA Fragmentation; DN | 2017 |
Serum microRNAs-217 and -375 as biomarkers of acute pancreatic injury in rats.
Topics: Acetaminophen; Acinar Cells; Acute Disease; Amylases; Animals; Biomarkers; Ceruletide; Disease Model | 2016 |
Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction.
Topics: Acetaminophen; Animals; Antioxidants; Cell Line; Chemical and Drug Induced Liver Injury; Cytoprotect | 2016 |
Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress.
Topics: Acetaminophen; Animals; Apoptosis; bcl-2-Associated X Protein; Chemical and Drug Induced Liver Injur | 2017 |
Autotransplantation of Spleen Mitigates Drug-Induced Liver Damage in Splenectomized Mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Erythrocyte | 2017 |
Dehydrogenase interference with enzymatic ethanol assays: forgotten but not gone.
Topics: Acetaminophen; Ethanol; False Positive Reactions; Humans; L-Lactate Dehydrogenase; Lactic Acid; Live | 2008 |
Effects of erdosteine on acetaminophen-induced hepatotoxicity in rats.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Catalase; D | 2008 |
The effects of royal jelly on liver damage induced by paracetamol in mice.
Topics: Acetaminophen; Amino Acids; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injur | 2009 |
Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Bone Marrow; Female; Flow Cytometry; Hu | 2008 |
Protection of acetaminophen induced mitochondrial dysfunctions and hepatic necrosis via Akt-NF-kappaB pathway: role of a novel plant protein.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Apoptosis; Cajanus; Cell Survival; C | 2009 |
CD24 and Siglec-10 selectively repress tissue damage-induced immune responses.
Topics: Acetaminophen; Animals; CD24 Antigen; Cytokines; Dendritic Cells; HMGB1 Protein; HSP70 Heat-Shock Pr | 2009 |
Post-endoscopic retrograde cholangiopancreatography uvular necrosis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Cholangiopancreatography, Endoscopic Retrograde; Humans; Ma | 2009 |
Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen.
Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartat | 2009 |
CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; | 2009 |
Phyllanthus urinaria extract attenuates acetaminophen induced hepatotoxicity: involvement of cytochrome P450 CYP2E1.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1 Inhibitors; | 2009 |
Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Aspar | 2009 |
[Acute renal failure after acetaminophen poisoning: report of three cases].
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Analgesics, Non-Narcotic; Anuria; Creatinine; | 2009 |
High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo.
Topics: Acetaminophen; Acetylation; Amino Acid Sequence; Animals; Apoptosis; Blotting, Western; Caspase Inhi | 2009 |
Protective Effects of the Supernatant of Ethanol Eluate from Artemisia sacrorum Ledeb. against Acetaminophen-Induced Liver Injury in Mice [corrected].
Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; Artemisia; Aspartate Aminotransferases; Cas | 2009 |
Acanthoic acid, a diterpene in Acanthopanax koreanum, protects acetaminophen-induced hepatic toxicity in mice.
Topics: Acetaminophen; Animals; Antioxidants; Caspase 3; Chemical and Drug Induced Liver Injury; Diterpenes; | 2010 |
Acute exposure to ozone exacerbates acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Bromodeoxyuridine; Bronchoal | 2010 |
Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury.
Topics: Acetaminophen; Alanine Transaminase; Albumins; Analgesics, Non-Narcotic; Anesthetics, Local; Animals | 2010 |
Human recombinant vascular endothelial growth factor reduces necrosis and enhances hepatocyte regeneration in a mouse model of acetaminophen toxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytokines; | 2010 |
Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; CD18 Antigens; Chemical and Drug Induc | 2010 |
Increased mitochondrial stress and modulation of mitochondrial respiratory enzyme activities in acetaminophen-induced toxicity in mouse macrophage cells.
Topics: Acetaminophen; Adenosine Triphosphate; Analgesics, Non-Narcotic; Animals; Apoptosis; Caspase 3; Cell | 2010 |
rhIL-1Ra reduces hepatocellular apoptosis in mice with acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Apoptosis; Aspartate Aminotr | 2010 |
Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Inju | 2010 |
Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cyclophilins; | 2011 |
Histopathology and biochemistry analysis of the interaction between sunitinib and paracetamol in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antineoplastic Agents; Antipyretics; Biomarkers; B | 2010 |
The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 2011 |
HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Cysteine; Female; | 2011 |
Necrosis versus apoptosis in acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Liver Failure, Acute; Mic | 2011 |
Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Apoptosis Inducing Factor; Blotting, Western; Chemical and Drug Induced Live | 2011 |
Susceptibility of rat non-alcoholic fatty liver to the acute toxic effect of acetaminophen.
Topics: Acetaminophen; Animals; Biomarkers; Caspase 3; Chemical and Drug Induced Liver Injury; Cholesterol; | 2012 |
Evaluation of phytoconstituents and anti-nephrotoxic and antioxidant activities of Monochoria vaginalis.
Topics: Acetaminophen; Animals; Antioxidants; Creatine; Disease Models, Animal; Ethanol; Kidney Diseases; Ma | 2011 |
Circulating apoptotic and necrotic cell death markers in patients with acute liver injury.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analysis of Variance; Apoptosis; Biomarkers; C | 2011 |
Apical membrane rupture and backward bile flooding in acetaminophen-induced hepatocyte necrosis.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Bile Canaliculi; Cell M | 2011 |
Elevated serum neopterin levels in acetaminophen-induced liver injury.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2011 |
Interaction of α-melanocortin and its pentapeptide antisense LVKAT: effects on hepatoprotection in male CBA mice.
Topics: Acetaminophen; Alanine Transaminase; alpha-MSH; Amino Acid Sequence; Animals; Antisense Elements (Ge | 2011 |
Pentraxin 3 as a potential biomarker of acetaminophen-induced liver injury.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Biomarkers; C-Reactive Prote | 2013 |
Multimodal analgesia including infraclavicular block in perioperative management of upper extremity amputation in neonate.
Topics: Acetaminophen; Amputation, Surgical; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesth | 2011 |
Changes in mouse liver protein glutathionylation after acetaminophen exposure.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2012 |
Identification of urinary microRNA profiles in rats that may diagnose hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bio | 2012 |
RETRACTED: Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity.
Topics: Acetaminophen; Adult; Alanine Transaminase; Apoptosis; Biomarkers; Case-Control Studies; Chemical an | 2012 |
Complement activation in acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Complement Act | 2012 |
The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation.
Topics: Acetaminophen; Adult; Aged; Alanine Transaminase; Animals; Biomarkers; Caspase 3; Chemical and Drug | 2012 |
P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Antigens, CD; Antipyretics; Apyrase; Cells, Cultured; Chemical and Drug Indu | 2012 |
Nasopharyngeal necrosis after chronic opioid (oxycodone/acetaminophen) insufflation.
Topics: Acetaminophen; Adult; Drug Combinations; Female; Humans; Insufflation; Nasopharynx; Necrosis; Oxycod | 2012 |
The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2012 |
Role of galectin-3 in acetaminophen-induced hepatotoxicity and inflammatory mediator production.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biotransformation; Chemical and Drug Induced Liver | 2012 |
Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure.
Topics: Acetaminophen; Acute Lung Injury; Acute-Phase Reaction; Adolescent; Adult; Analysis of Variance; Ani | 2012 |
Biochemical and histologic presentations of female Wistar rats administered with different doses of paracetamol/methionine.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Female; Li | 2011 |
Mitogen-activated protein kinase phosphatase (Mkp)-1 protects mice against acetaminophen-induced hepatic injury.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Apoptosis; Chemical and Drug | 2012 |
Dietary fish oil aggravates paracetamol-induced liver injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 2013 |
Intranasal hydrocodone-acetaminophen abuse induced necrosis of the nasal cavity and pharynx.
Topics: Acetaminophen; Administration, Intranasal; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroid | 2012 |
ARC is a novel therapeutic approach against acetaminophen-induced hepatocellular necrosis.
Topics: Acetaminophen; Animals; Apoptosis Regulatory Proteins; Carcinoma, Hepatocellular; Disease Models, An | 2013 |
Mouse liver protein sulfhydryl depletion after acetaminophen exposure.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 2013 |
A reproducible, clinically relevant, intensively managed, pig model of acute liver failure for testing of therapies aimed to prolong survival.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Animals; Biomarkers; Cardiovascular Diseases; Chemic | 2013 |
Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antidotes; Chemical and Drug | 2002 |
Protection against acetaminophen hepatotoxicity by clofibrate pretreatment: role of catalase induction.
Topics: Acetaminophen; Administration, Oral; Amitrole; Analgesics, Non-Narcotic; Animals; Bile; Catalase; Ch | 2002 |
Mechanistic pathways of antioxidant cytoprotection by a novel IH636 grape seed proanthocyanidin extract.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Amiodarone; Analgesics, Non-Narcotic; Ani | 2002 |
Role of p55 tumor necrosis factor receptor 1 in acetaminophen-induced antioxidant defense.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antigens, CD; Antioxidants; Enzyme Induction; Glutathi | 2003 |
Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Chemi | 2003 |
Role of lipid peroxidation as a mechanism of liver injury after acetaminophen overdose in mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Diet; Drug Overdose; Enzyme | 2003 |
Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants.
Topics: Acetaminophen; Animals; Blotting, Western; Calpain; Carbon Tetrachloride; Carrier Proteins; Chemical | 2003 |
Effect of a potent iNOS inhibitor (ONO-1714) on acetaminophen-induced hepatotoxicity in the rat.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Amidines; Analgesics, Non-Narcotic; Anima | 2003 |
Effects of acetaminophen on myocardial infarct size in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Blood Pressure; Body Temperature; Disease Models, | 2003 |
Chronic liver disease in murine hereditary tyrosinemia type 1 induces resistance to cell death.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Cell Survival; Central Nervous System D | 2004 |
Liver necrosis and fulminant hepatic failure in rats: protection by oxyanionic form of tungsten.
Topics: Acetaminophen; Alkaline Phosphatase; Allopurinol; Animals; Bromobenzenes; Carbon Tetrachloride Poiso | 2004 |
N-acetylcysteine does not protect HepG2 cells against acetaminophen-induced apoptosis.
Topics: Acetaminophen; Acetylcysteine; Antioxidants; Apoptosis; Calcium; Cations, Divalent; Cell Line, Tumor | 2004 |
S-Adenosylmethionine protects against acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Analgesics; Animals; Cell Membrane Permeability; Chemical and Drug Induced Liver Inju | 2004 |
Acetaminophen and myocardial infarction in dogs.
Topics: Acetaminophen; Animals; Cardiotonic Agents; Collateral Circulation; Coronary Circulation; Dogs; Elec | 2004 |
Inhibition of matrix metalloproteinases minimizes hepatic microvascular injury in response to acetaminophen in mice.
Topics: Acetaminophen; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Enzyme Inhibit | 2005 |
Increased plasma biotinidase activity in rats with paracetamol-induced acute liver injury.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Albumins; Analgesics, Non-Narcotic; Animals; Bio | 2004 |
Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes.
Topics: Acetaminophen; Adenosine Triphosphate; Analgesics, Non-Narcotic; Animals; Apoptosis; Caspase 3; Casp | 2004 |
Long-term acetaminophen (paracetamol) treatment causes liver and kidney ultra-structural changes during rat pregnancy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Drug Administration Schedule; Endoplasmic Reticulu | 2004 |
The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetone; Analgesics, Non-Narcotic; Animals; Cytochrome P-450 CYP2E1; Enzyme Induction | 2005 |
Pathophysiological role of poly(ADP-ribose) polymerase (PARP) activation during acetaminophen-induced liver cell necrosis in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzamides; Biotransformation; Chemical and Drug I | 2005 |
Protective effect of alpha- and beta-amyrin, a triterpene mixture from Protium heptaphyllum (Aubl.) March. trunk wood resin, against acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bur | 2005 |
Transcriptional profiling of the left and median liver lobes of male f344/n rats following exposure to acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Gene Expression | 2005 |
Distinct roles of NF-kappaB p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Blotting, We | 2006 |
Geranylgeranylacetone protects against acetaminophen-induced hepatotoxicity by inducing heat shock protein 70.
Topics: Acetaminophen; Alanine Transaminase; Ammonia; Analgesics, Non-Narcotic; Animals; Anti-Ulcer Agents; | 2006 |
Deoxyribonuclease 1 aggravates acetaminophen-induced liver necrosis in male CD-1 mice.
Topics: Acetaminophen; Adenosine Triphosphate; Animals; Chemical and Drug Induced Liver Injury; Deoxyribonuc | 2006 |
Hepatoprotective activity of Psidium guajava Linn. leaf extract.
Topics: Acetaminophen; Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2006 |
Effect of hexane extract of Boswellia serrata oleo-gum resin on chemically induced liver damage.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Boswellia; Carbon Tetrachloride; Chemical and Drug | 2006 |
Peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP) but not PPAR-interacting protein (PRIP) is required for nuclear translocation of constitutive androstane receptor in mouse liver.
Topics: Acetaminophen; Active Transport, Cell Nucleus; Adenoviridae; Animals; Blotting, Northern; Cell Nucle | 2006 |
Pre-exposure to a novel nutritional mixture containing a series of phytochemicals prevents acetaminophen-induced programmed and unprogrammed cell deaths by enhancing BCL-XL expression and minimizing oxidative stress in the liver.
Topics: Acetaminophen; Animals; Apoptosis; bcl-X Protein; Cell Proliferation; Dietary Supplements; DNA Fragm | 2006 |
Artefactual contraction band necrosis of the myocardium in fatal air crashes.
Topics: Accidents, Aviation; Acetaminophen; Adult; Anabolic Agents; Analgesics, Non-Narcotic; Cannabinoids; | 2006 |
Recombinant platelet-activating factor-acetylhydrolase attenuates paracetamol-induced liver oxidative stress, injury, and regeneration.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Acetaminophen; Analgesics, Non-Narcotic; Animals; Li | 2007 |
Mild hypothermia attenuates liver injury and improves survival in mice with acetaminophen toxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Body Temperature; Cell Count; Cell Divi | 2007 |
Gene expression analysis offers unique advantages to histopathology in liver biopsy evaluations.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biopsy; Cytochrome P-450 Enzyme System; Dose-Respo | 2007 |
Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; bcl-X Protein; Enzyme Inhibitors; Immun | 2007 |
Rhabdomyolysis and necrotic bowel after acetaminophen and ibuprofen overdose.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Blood Chemical Analysis; Drug Overdose; Humans; Ibup | 2007 |
Simultaneous clustering of gene expression data with clinical chemistry and pathological evaluations reveals phenotypic prototypes.
Topics: Acetaminophen; Algorithms; Animals; Clinical Chemistry Tests; Cluster Analysis; Data Interpretation, | 2007 |
Sensitivity of (1)H NMR analysis of rat urine in relation to toxicometabonomics. Part I: dose-dependent toxic effects of bromobenzene and paracetamol.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2007 |
Specific activation of the different fibrogenic cells in rat cultured liver slices mimicking in vivo situations.
Topics: Acetaminophen; Acetylcysteine; Animal Use Alternatives; Animals; Antioxidants; Bile Ducts, Intrahepa | 2007 |
Chromatin breakdown by deoxyribonuclease1 promotes acetaminophen-induced liver necrosis: an ultrastructural and histochemical study on male CD-1 mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2007 |
Role of apoptosis in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Apoptosis; Cell Membrane Permeability; Cells, Cultured; Chemical and Drug In | 2007 |
Hepatic injury induces contrasting response in liver and kidney to chemicals that are metabolically activated: role of male sex hormone.
Topics: Acetaminophen; Aminopyrine N-Demethylase; Animals; Biotransformation; Carbon Tetrachloride; Chemical | 2007 |
Hepatoprotective effect of L-carnitine against acute acetaminophen toxicity in mice.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Ami | 2007 |
Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; bcl-2-Associated X Protein; Chemical and Drug Indu | 2008 |
Complete soft palate necrosis and velopharyngeal insufficiency resulting from intranasal inhalation of prescription narcotics and cocaine.
Topics: Acetaminophen; Administration, Inhalation; Adult; Analgesics, Opioid; Cocaine; Cocaine-Related Disor | 2007 |
The release of DNA into the plasma of mice following hepatic cell death by apoptosis and necrosis.
Topics: Acetaminophen; Animals; Apoptosis; Biomarkers; Carbon Tetrachloride; DNA; Female; L-Lactate Dehydrog | 2008 |
Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity.
Topics: Acetaminophen; Animals; Apoptosis; Carbon Tetrachloride; Down-Regulation; Fibrosis; Forecasting; Gli | 2008 |
Cytochrome c: a non-invasive biomarker of drug-induced liver injury.
Topics: Acetaminophen; Acute Disease; Animals; Apoptosis; Biomarkers; Chemical and Drug Induced Liver Injury | 2008 |
Apoptosis versus necrosis rate as a predictor in acute liver failure following acetaminophen intoxication compared with acute-on-chronic liver failure.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Apoptosis; Biomarkers; Humans; Liver Failure, A | 2008 |
Protection by bicyclol derivatives against acetaminophen-induced acute liver failure in mice and its active mechanism.
Topics: Acetaminophen; Adenosine Triphosphate; Analgesics, Non-Narcotic; Animals; Apoptosis; Apoptosis Induc | 2008 |
Human hepatocytes can repopulate mouse liver: histopathology of the liver in human hepatocyte-transplanted chimeric mice and toxicologic responses to acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Cell Proliferation; Female; Hepatocytes | 2008 |
Plasminogen activator inhibitor-1 limits liver injury and facilitates regeneration after acetaminophen overdose.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li | 2008 |
Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid | 2008 |
Effects of acetaminophen on hepatic gene expression in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Dose-Response Relationshi | 2006 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv | 1984 |
Cardiovascular lesions in Sprague-Dawley rats induced by long-term treatment with caffeine.
Topics: Acetaminophen; Animals; Antipyrine; Caffeine; Cardiovascular Diseases; Heart; Male; Myocardial Infar | 1981 |
Drug-induced lipid peroxidation in mice--II. Protection against paracetamol-induced liver necrosis by intravenous liposomally entrapped glutathione.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Benzo(a)pyrene; Benzopyrenes; Chemical and Drug | 1982 |
Examination of the protective effect of ICRF-187 and dimethyl sulfoxide against acetaminophen-induced hepatotoxicity in Syrian golden hamsters.
Topics: Acetaminophen; Alanine Transaminase; Animals; Blood Proteins; Chemical and Drug Induced Liver Injury | 1983 |
The role of metabolic activation of analgesics and non-steroidal anti-inflammatory drugs in the development of renal papillary necrosis and upper urothelial carcinoma.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; B | 1984 |
Protective action of 2(3)-tert-butyl-4-hydroxyanisole (BHA) on acetaminophen-induced liver necrosis in male A/J mice.
Topics: Acetaminophen; Animals; Anisoles; Butylated Hydroxyanisole; Chemical and Drug Induced Liver Injury; | 1984 |
Acute liver failure and encephalopathy in a 15-month-old infant.
Topics: Acetaminophen; Acute Disease; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Diagnosis, Dif | 1983 |
Histological & ultrastructural alterations in the livers of albino rats after prolonged administration of paracetamol.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Liver; | 1983 |
Reversal of acetaminophen intoxication with an N-acetylcysteine-liposome preparation.
Topics: Acetaminophen; Acetylcysteine; Animals; Lethal Dose 50; Liposomes; Liver; Male; Mice; Necrosis | 1983 |
Scanning electron microscopic examination of acetaminophen-induced hepatotoxicity and congestion in mice.
Topics: Acetaminophen; Animals; Cell Membrane; Chemical and Drug Induced Liver Injury; Erythrocytes; Liver; | 1983 |
Fatal acetaminophen toxicity in a 2-year-old.
Topics: Acetaminophen; Antidotes; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; H | 1983 |
Potentiation of the toxic effects of acetaminophen in mice by concurrent infection with influenza B virus: a possible mechanism for human Reye's syndrome?
Topics: Acetaminophen; Animals; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Ind | 1984 |
Quantitative liver function and morphology after paracetamol administration to rats.
Topics: Acetaminophen; Animals; Fatty Liver; Female; Galactose; Lethal Dose 50; Liver; Necrosis; Prothrombin | 1981 |
Severe hepatic damage after acetaminophen use in psittacosis.
Topics: Acetaminophen; Humans; Liver; Liver Diseases; Male; Middle Aged; Necrosis; Psittacosis | 1983 |
[Hepatic lesion caused by acetaminophen. Apropos of a case with unusual portal involvement].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Inflammation; Male; Middle Aged; Necr | 1983 |
The predictive value of changes in antipyrine pharmacokinetics in halothane and paracetamol induced hepatic necrosis in rats.
Topics: Acetaminophen; Animals; Antipyrine; Chemical and Drug Induced Liver Injury; Half-Life; Halothane; Ki | 1983 |
Glutathione thresholds in reactive metabolite toxicity.
Topics: Acetaminophen; Animals; Biotransformation; Bromobenzenes; Cricetinae; Dose-Response Relationship, Dr | 1980 |
Paracetamol poisoning--hepatic protection by n-acetylcysteine.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Cystine; Humans; Male; Necrosis | 1982 |
Bacteraemia in patients with fulminant hepatic failure.
Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; H | 1982 |
Prevention of acetaminophen-induced hepatic necrosis by cimetidine in mice.
Topics: Acetaminophen; Animals; Cimetidine; Female; Guanidines; Liver; Mice; Necrosis | 1981 |
Cimetidine protects against acetaminophen hepatotoxicity in rats.
Topics: Acetaminophen; Alanine Transaminase; Aminopyrine; Animals; Aspartate Aminotransferases; Chemical and | 1981 |
Hepatotoxicity of phenacetin and paracetamol in the Gunn rat.
Topics: Acetaminophen; Animals; Female; Liver; Necrosis; Nephritis, Interstitial; Phenacetin; Rats; Rats, Gu | 1981 |
Mechanism of the protective effect of propylthiouracil against acetaminophen (Tylenol) toxicity in the rat.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 1980 |
Acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver; Male; Mice; Necrosis | 1980 |
Apparent potentiation of acetaminophen hepatotoxicity by alcohol.
Topics: Acetaminophen; Drug Synergism; Ethanol; Humans; Jaundice; Liver; Male; Middle Aged; Necrosis | 1980 |
Potentiation of acetaminophen hepatotoxicity by alcohol.
Topics: Acetaminophen; Adult; Alcoholism; Drug Synergism; Ethanol; Humans; Liver; Male; Middle Aged; Necrosi | 1980 |
N-Acetyl-DL-penicillamine and acetaminophen toxicity in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Male; Mice; Necrosis | 1980 |
Effectiveness of methyrapone in the treatment of acetaminophen toxicity in mice.
Topics: Acetaminophen; Animals; Female; Glutathione; Lethal Dose 50; Liver; Metyrapone; Mice; Necrosis; Time | 1980 |
An integrated approach to the study of chemically reactive metabolites of acetaminophen.
Topics: Acetaminophen; Animals; Antidotes; Biotransformation; Cricetinae; Cysteamine; Cysteine; Dose-Respons | 1981 |
Comparison of thermally oxidized lipids and acetaminophen with concurrent consumption of ethanol as inducers of liver cirrhosis.
Topics: Acetaminophen; Acute-Phase Reaction; Analysis of Variance; Animals; Benzoquinones; DNA; Drug Interac | 1995 |
Protective effect of oleanolic acid against chemical-induced acute necrotic liver injury in mice.
Topics: Acetaminophen; Animals; Cadmium Poisoning; Carbon Tetrachloride Poisoning; Chemical and Drug Induced | 1995 |
[A case of paracetamol retard poisoning with fatal outcome].
Topics: Acetaminophen; Adult; Delayed-Action Preparations; Drug Overdose; Fatal Outcome; Female; Humans; Liv | 1995 |
Immunohistochemical localization of acetaminophen in target tissues of the CD-1 mouse: correspondence of covalent binding with toxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cytochrome | 1995 |
Clofibrate pretreatment diminishes acetaminophen's selective covalent binding and hepatotoxicity.
Topics: Acetaminophen; Analysis of Variance; Animals; Blotting, Western; Carrier Proteins; Clofibrate; Cytoc | 1994 |
Non-parenchymal cell responses in paracetamol (acetaminophen)-induced liver injury.
Topics: Acetaminophen; Biopsy; Cell Count; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Hu | 1994 |
Investigation of possible mechanisms of hepatic swelling and necrosis caused by acetaminophen in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Cell Adhesion Molecules; Intercellular Adhesion Molecu | 1993 |
4-Methylpyrazole blocks acetaminophen hepatotoxicity in the rat.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Dose-Response Relationshi | 1994 |
Misoprostol protection against acetaminophen-induced hepatotoxicity in the rat.
Topics: Acetaminophen; Alanine Transaminase; Animals; Disease Models, Animal; Drug Overdose; Liver; Male; Mi | 1994 |
The role of transjugular liver biopsy in fulminant liver failure: relation to other prognostic indicators.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Biopsy; Chi-Square Distribution; Child; C | 1993 |
Effect of thiola on acetaminophen induced hepatic necrosis in mice.
Topics: Acetaminophen; Animals; Behavior, Animal; Chemical and Drug Induced Liver Injury; Drug Interactions; | 1993 |
Cytochrome P450 and glutathione in the liver of rats under exclusive sucrose ingestion.
Topics: Acetaminophen; Animals; Antipyrine; Body Weight; Cholesterol Side-Chain Cleavage Enzyme; Fasting; Gl | 1993 |
Phenylpropanolamine potentiation of acetaminophen-induced hepatotoxicity: evidence for a glutathione-dependent mechanism.
Topics: Acetaminophen; Alanine Transaminase; Animals; Dose-Response Relationship, Drug; Drug Synergism; Glut | 1993 |
Ca2+ antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen.
Topics: Acetaminophen; Animals; Biotransformation; Calcium; Calcium Channel Blockers; Cell Death; Chlorproma | 1993 |
Fulminant hepatitis associated with centrilobular hepatic necrosis in young children.
Topics: Acetaminophen; Child, Preschool; Female; Fever; Hepatic Encephalopathy; Humans; Infant; Liver; Male; | 1995 |
[Plasma levels of alanine aminotransferase in experimental liver necrosis induced by overdosage of paracetamol in mice].
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Female; Liver; | 1995 |
Acute hepatotoxicity of acetaminophen in rats treated with ethanol plus isopentanol.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug In | 1995 |
Hepatoprotective effects of the shark bile salt 5beta-scymnol on acetaminophen-induced liver damage in mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Bile Acids and Salts; Chemical and Dru | 1996 |
Acetaminophen-induced hepatotoxicity is associated with early changes in AP-1 DNA binding activity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dimerization; DNA; Female; Gene Expr | 1996 |
Morphology of hepatic stellate cells in patients with fulminant or subfulminant hepatitis requiring liver transplantation.
Topics: Acetaminophen; Actins; Adult; Aged; Amanita; Autoimmune Diseases; Biomarkers; Cell Differentiation; | 1996 |
Increased resistance to acetaminophen-induced hepatotoxicity in retrovirus-infected mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biotransformation; Chemical and Drug Induced Liver | 1996 |
Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment.
Topics: Acetaminophen; Animals; Apoptosis; Cholesterol Esters; DNA Fragmentation; Liver; Male; Mice; Microsc | 1996 |
Hepatic necrosis masquerading as trauma.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child, Preschool; Diagnosis, Differential; Humans; Liver; M | 1997 |
Correlation between the severity of acute hepatic necrosis induced by acetaminophen and serum aminotransferase levels in fasted and sucrose-fed rats.
Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical a | 1996 |
Calcium-dependent DNA damage and adenosine 3',5'-cyclic monophosphate-independent glycogen phosphorylase activation in an in vitro model of acetaminophen-induced liver injury.
Topics: Acetaminophen; Animals; Calcium; Cell Death; Cells, Cultured; Chemical and Drug Induced Liver Injury | 1997 |
Cimetidine enhances the hepatoprotective action of N-acetylcysteine in mice treated with toxic doses of paracetamol.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alanine Transaminase; Analgesics, Non-Narcotic; | 1997 |
[Fatal acute liver damage caused by a therapeutic dose of paracetamol].
Topics: Acetaminophen; Adolescent; Chemical and Drug Induced Liver Injury; Child, Preschool; Dose-Response R | 1998 |
Emergency! Acetaminophen overdose.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anorexia Nervosa; Chemical and Drug Induced Liv | 1998 |
The effects of glutathione glycoside in acetaminophen-induced liver cell necrosis.
Topics: Acetaminophen; Animals; Drug Overdose; Glutathione; Glycosides; Humans; Lipid Peroxidation; Liver; M | 1998 |
Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Cytochrome P-450 CYP1A2; Cyt | 1998 |
Comparison of paracetamol-induced hepatotoxicity in the rat in vivo with progression of cell injury in vitro in rat liver slices.
Topics: Acetaminophen; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cytochrome P-450 Enzyme Syste | 1998 |
Role of neutrophils in hepatotoxicity induced by oral acetaminophen administration in rats.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Antibodies; Liver; Male; Necrosi | 1998 |
Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species.
Topics: Acetaminophen; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; | 1999 |
Hypothyroidism protects rat liver from acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Chemical and Drug Induced Li | 1999 |
A novel proanthocyanidin IH636 grape seed extract increases in vivo Bcl-XL expression and prevents acetaminophen-induced programmed and unprogrammed cell death in mouse liver.
Topics: Acetaminophen; Alanine Transaminase; Animals; Anthocyanins; Antioxidants; Apoptosis; bcl-X Protein; | 1999 |
Macrophage inflammatory protein-2 gene therapy attenuates adenovirus- and acetaminophen-mediated hepatic injury.
Topics: Acetaminophen; Acute Disease; Adenoviridae; Animals; Chemokine CXCL2; Female; Gene Expression; Genet | 1999 |
[Hepatoprotective effect of flower pollen lipid extract in paracetamol-induced hepatotoxicity in mice].
Topics: Acetaminophen; Animals; Cytoprotection; Lipids; Liver; Male; Mice; Mitochondria; Necrosis; Organelle | 1997 |
The canals of Hering and hepatic stem cells in humans.
Topics: Acetaminophen; Adult; Aged; alpha-Fetoproteins; Bile Ducts, Intrahepatic; Biomarkers; Female; Humans | 1999 |
A hepatotoxic dose of acetaminophen modulates expression of BCL-2, BCL-X(L), and BCL-X(S) during apoptotic and necrotic death of mouse liver cells in vivo.
Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; bcl-X Protein; Blotting, Western; Cell Nucl | 2000 |
Western blot analysis for nitrotyrosine protein adducts in livers of saline-treated and acetaminophen-treated mice.
Topics: Acetaminophen; Adjuvants, Immunologic; Analgesics, Non-Narcotic; Animals; Blotting, Western; Cattle; | 2000 |
Inhibition of tumour necrosis factor alpha does not prevent experimental paracetamol-induced hepatic necrosis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Enzyme-Linked Immunos | 2000 |
Exaggerated hepatic injury due to acetaminophen challenge in mice lacking C-C chemokine receptor 2.
Topics: Acetaminophen; Animals; Antibodies; Apoptosis; Chemical and Drug Induced Liver Injury; Chemokine CCL | 2000 |
The hepatic inflammatory response after acetaminophen overdose: role of neutrophils.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; CD18 Antigens; Chemokines, CXC; Drug Overdose; Flo | 2000 |
Effect of Azadirachta indica (Neem) leaf aqueous extract on paracetamol-induced liver damage in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Glycerides | 2000 |
Peroxisome proliferator-activated receptor alpha-null mice lack resistance to acetaminophen hepatotoxicity following clofibrate exposure.
Topics: Acetaminophen; Administration, Oral; Analgesics; Animals; Chemical and Drug Induced Liver Injury; Cl | 2000 |
In vivo protection of dna damage associated apoptotic and necrotic cell deaths during acetaminophen-induced nephrotoxicity, amiodarone-induced lung toxicity and doxorubicin-induced cardiotoxicity by a novel IH636 grape seed proanthocyanidin extract.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Amiodarone; Animals; Antioxidants; Apopto | 2000 |
Role of taurine in preventing acetaminophen-induced hepatic injury in the rat.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Narcotic; Animals; Apopto | 2001 |
Potential role for Duffy antigen chemokine-binding protein in angiogenesis and maintenance of homeostasis in response to stress.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antigens, Protozoan; Carrier Proteins; Chemokines, | 2002 |
Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis?
Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; Blotting, Western; Caspase 3; Caspases; Foo | 2002 |
Comparison of the therapeutic efficacy of 4-methylpyrazole and N-acetylcysteine on acetaminophen (paracetamol) hepatotoxicity in rats.
Topics: Acetaminophen; Acetylcysteine; Alcohol Dehydrogenase; Analgesics, Non-Narcotic; Animals; Antidotes; | 2002 |
Effects of "Chinese yam" on hepato-nephrotoxicity of acetaminophen in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Dioscorea; | 2002 |
Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes.
Topics: Acetaminophen; Animals; Antioxidants; Apoptosis; Butylated Hydroxytoluene; Caspase Inhibitors; Caspa | 2002 |
Letter: Paracetamol hepatoxicity.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Humans; Liver; Necrosis | 1976 |
Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; | 1976 |
Chronic hepatic inflammation and fibrosis due to low doses of paracetamol.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chronic Disease; Hip Joint; Humans; Joint Dis | 1978 |
Experimental acetaminophen-induced hepatic necrosis: biochemical and electron microscopic study of cysteamine protection.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cricetinae; Cysteamine; Electron Tra | 1978 |
Prevention of paracetamol-induced liver damage in mice with glutathione.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Gl | 1975 |
Clinical and experimental aspects of paracetamol hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Humans; Liver; Necrosis | 1977 |
Experimental hepatic injury: the sequential changes in drug metabolizing enzyme activities after administration of acetaminophen.
Topics: Acetaminophen; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Chemical and Drug Induced Li | 1977 |
Hyperthermia and rhabdomyolysis in self-poisoning with paracetamol and salicylates. Report of a case.
Topics: Acetaminophen; Adult; Female; Fever; Humans; Muscles; Muscular Diseases; Myoglobinuria; Necrosis; Sa | 1979 |
Cocaine-induced hepatic necrosis in mice--the role of cocaine metabolism.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cocaine | 1979 |
Management of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Humans; Liver; Necrosis | 1979 |
Paracetamol poisoning. Prevention of liver damage.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Necrosis | 1979 |
Acetaminophen and the liver.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Humans; Liver Cirrhosis; Male; Necrosi | 1978 |
Paracetamol poisoning.
Topics: Acetaminophen; Humans; Liver; Mortality; Necrosis; United Kingdom | 1978 |
Decreased toxicity of the N-methyl analogs of acetaminophen and phenacetin.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cricetinae; Male; Mesocricetus; Meth | 1978 |
Acetaminophen overdose and hepatic necrosis.
Topics: Acetaminophen; Female; Humans; Liver; Middle Aged; Necrosis | 1978 |
Evaluation of paracetamol-induced damage in liver biopsies. Acute changes and follow-up findings.
Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Dose-Response Relationship | 1976 |
Acetaminophen and hepatic necrosis.
Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Necrosis | 1977 |
Hepatotoxicity of paracetamol enhanced by ingestion of alcohol: report of two cases.
Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Cysteamine; Female; Humans | 1977 |
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 23--1977.
Topics: Acetaminophen; Acute Disease; Adolescent; Arthritis, Juvenile; Aspirin; Brain Death; Brain Edema; Ch | 1977 |
Acetaminophen toxity.
Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Li | 1977 |
Liver function and structure in survivors of acetaminophen poisoning. A follow-up study of serum bile acids and liver histology.
Topics: Acetaminophen; Aspartate Aminotransferases; Bile Acids and Salts; Chemical and Drug Induced Liver In | 1977 |
Fatal massive hepatic necrosis following acetaminophen overdose.
Topics: Acetaminophen; Adult; Autopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Kidney; Kidne | 1976 |
Editorial: Paracetamol and the liver.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Liver; Liver Dis | 1976 |
The effect of diet on the toxicity of paracetamol and the safety of paracetamol-methionine mixtures.
Topics: Acetaminophen; Animals; Body Weight; Caseins; Chemical and Drug Induced Liver Injury; Cysteine; Cyto | 1975 |
Acetaminophen poisoning and toxicity.
Topics: Acetaminophen; Agranulocytosis; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Hypoglyc | 1975 |
Experimental paracetamol-induced hepatic necrosis: a light- and electron-microscope, and histochemical study.
Topics: Acetaminophen; Acid Phosphatase; Animals; Chemical and Drug Induced Liver Injury; Endoplasmic Reticu | 1975 |
Effect of liposomal entrapment on the protective action of glutathione against paracetamol-induced liver necrosis.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Glutathione; Liposomes; L | 1975 |
Serum transaminase levels after experimental paracetamol-induced hepatic necrosis.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 1975 |
Histopathological changes in the liver following a paracetamol overdose: correlation with clinical and biochemical parameters.
Topics: Acetaminophen; Adolescent; Adult; Bilirubin; Chemical and Drug Induced Liver Injury; Female; Follow- | 1975 |
Why do people use paracetamol for suicide?
Topics: Acetaminophen; Drug Prescriptions; Female; Humans; Liver; Male; Necrosis; Nonprescription Drugs; Sui | 1976 |
[Drug induced liver injury. Chemical liver necrosis caused by formation of reactive metabolites].
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug | 1976 |
Immunolocalization of regenerating cells after submassive liver necrosis using PCNA staining.
Topics: Acetaminophen; Acute Disease; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Immunoh | 1992 |
Paracetamol toxicity in chronic alcohol abusers--a plea for greater consumer awareness.
Topics: Acetaminophen; Alcoholism; Gastritis; Health Education; Humans; Liver; Male; Middle Aged; Necrosis | 1992 |
Protective effect of deferoxamine for acetaminophen induced liver injury.
Topics: Acetaminophen; Animals; Deferoxamine; Dose-Response Relationship, Drug; Liver; Male; Necrosis; Rats; | 1992 |
Effect of pregnenolone-16 alpha-carbonitrile and dexamethasone on acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Bile; Dexamethasone; Glutathione; L-Iditol 2-Dehydroge | 1992 |
Fatal acetaminophen poisoning with evidence of subendocardial necrosis of the heart.
Topics: Acetaminophen; Adolescent; Drug Overdose; Endocardium; Female; Heart Transplantation; Humans; Kidney | 1991 |
Protective effects of propylene glycol, a solvent used pharmaceutically, against paracetamol-induced liver injury in mice.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Blood Glucose; Drug Antagonism; Liver; Male; Mi | 1991 |
Postnatal mice have low susceptibility to paracetamol toxicity.
Topics: Acetaminophen; Age Factors; Animals; Animals, Newborn; Benzoquinones; Chemical and Drug Induced Live | 1991 |
Necrotizing myopathy in critically-ill patients.
Topics: Acetaminophen; Aortic Aneurysm; Bacterial Infections; Critical Care; Eclampsia; Female; Humans; Immu | 1991 |
Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: correlation of nuclear Ca2+ accumulation and early DNA fragmentation with cell death.
Topics: Acetaminophen; Animals; Calcium; Cell Death; Cell Nucleus; DNA; DNA Damage; Liver; Male; Mice; Necro | 1991 |
Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adult; Aspartate Aminotransferases; Drug Evaluation; F | 1990 |
Prevention of acetaminophen-induced hepatotoxicity by endotoxin in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Endotoxins; Es | 1990 |
Influence of timing of administration of liposome-encapsulated superoxide dismutase on its prevention of acetaminophen-induced liver cell necrosis in rats.
Topics: Acetaminophen; Animals; Drug Carriers; Lipid Peroxidation; Liposomes; Liver; Male; Necrosis; Rats; R | 1990 |
Early loss of large genomic DNA in vivo with accumulation of Ca2+ in the nucleus during acetaminophen-induced liver injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Calcium; Cell Nucleus; Cell Survival; Chemical and Dru | 1990 |
Acetaminophen hepatotoxicity: is there a role for prostaglandin synthesis?
Topics: Acetaminophen; Animals; Aspirin; Chemical and Drug Induced Liver Injury; Glutathione; Hexobarbital; | 1990 |
Hepatoprotective effects of cystathionine against acetaminophen-induced necrosis.
Topics: Acetaminophen; Alkynes; Animals; Cystathionine; Glutathione; Glycine; Liver; Male; Necrosis; Pargyli | 1989 |
Comparative study on the toxicity of acetaminophen and mercuric chloride in normal and athymic mice and rats.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Female; Kidney Cortex; Male; Mercuri | 1989 |
[Drugs cytoprotective of the gastric mucosa against ethanol damage].
Topics: Acetaminophen; Aluminum Hydroxide; Animals; Bicarbonates; Drug Evaluation, Preclinical; Enprostil; E | 1988 |
Effect of hyperoxia on liver necrosis induced by hepatotoxins.
Topics: Acetaminophen; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cric | 1986 |
Nyquil-associated liver injury.
Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Dextromethorphan; Doxylami | 1989 |
Development of paracetamol induced hepatocellular tolerance in albino rats.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Drug Tolerance; Liver; Necrosis; Rats; Rats, Inbred St | 1988 |
Long-term sequellae of acetaminophen-associated fulminant hepatic failure: relevance of early histology.
Topics: Acetaminophen; Acute Disease; Chemical and Drug Induced Liver Injury; Female; Follow-Up Studies; Hep | 1988 |
Protection by dimethylsulfoxide against acetaminophen-induced hepatic, but not respiratory toxicity in the mouse.
Topics: Acetaminophen; Animals; Carbon Tetrachloride; Dimethyl Sulfoxide; Female; Free Radicals; Glutathione | 1988 |
Neutrophilic eccrine hidradenitis in the absence of an underlying malignancy.
Topics: Acetaminophen; Eccrine Glands; Epithelium; Humans; Inflammation; Male; Middle Aged; Necrosis; Neutro | 1988 |
Severe liver damage caused by therapeutic doses of acetaminophen.
Topics: Acetaminophen; Alanine Transaminase; Alcohol Drinking; Aspartate Aminotransferases; Chemical and Dru | 1987 |
Extrahepatic lesions induced by acetaminophen in the mouse.
Topics: Acetaminophen; Animals; Kidney; Lung; Lymphoid Tissue; Male; Mice; Necrosis; Testis | 1987 |
Ultrastructural changes during acute acetaminophen-induced hepatotoxicity in the mouse: a time and dose study.
Topics: Acetaminophen; Animals; Dose-Response Relationship, Drug; Liver; Male; Mice; Mitochondria, Liver; Ne | 1987 |
Maternal acetaminophen overdose at 15 weeks of gestation.
Topics: Acetaminophen; Acetylcysteine; Adult; Female; Fetus; Humans; Liver; Necrosis; Pregnancy; Pregnancy C | 1986 |
[Severe liver damage following therapeutic dose of paracetamol].
Topics: Acetaminophen; Adolescent; Adult; Alcohol Drinking; Chemical and Drug Induced Liver Injury; Drug Syn | 1987 |
[Severe liver damage following suicidal intake of paracetamol].
Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Mal | 1987 |
Paracetamol, 3-monoalkyl- and 3,5-dialkyl derivatives: comparison of their hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Liver; Male; Mice; Necros | 1987 |
Time development of distribution and toxicity following single toxic APAP doses in male BOM:NMRI mice.
Topics: Acetaminophen; Animals; Autoradiography; Body Weight; Chemical and Drug Induced Liver Injury; Glutat | 1987 |
Lack of cytoprotection by acetaminophen against ethanol-, HCl.ethanol- and HCl.aspirin-induced gastric mucosal lesions in rats.
Topics: 16,16-Dimethylprostaglandin E2; Acetaminophen; Animals; Aspirin; Ethanol; Gastric Mucosa; Hydrochlor | 1987 |
Alcohol, acetaminophen, and hepatic necrosis.
Topics: Acetaminophen; Adult; Alcoholism; Humans; Liver Diseases; Male; Necrosis | 1986 |
Anomalous susceptibility of the fasted hamster to acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Criceti | 1986 |
[Paracetamol poisoning with fatal necrosis of the liver].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Female; Humans; Kidney Tubular Necrosis, Acut | 1986 |
Mechanisms of fasting-induced potentiation of acetaminophen hepatotoxicity in the rat.
Topics: Acetaminophen; Animals; Drug Synergism; Fasting; Glucuronates; Glutathione; Half-Life; Kinetics; Liv | 1987 |
Lethal enhancement of therapeutic doses of acetaminophen by alcohol.
Topics: Acetaminophen; Autopsy; Bacterial Infections; Chemical and Drug Induced Liver Injury; Drug Synergism | 1986 |
Effects of calcium channel blocking agents on calcium and centrilobular necrosis in the liver of rats treated with hepatotoxic agents.
Topics: Acetaminophen; Animals; Calcium; Calcium Channel Blockers; Carbon Tetrachloride; Chemical and Drug I | 1986 |
Acetaminophen hepatotoxicity: studies on the mechanism of cysteamine protection.
Topics: Acetaminophen; Animals; Cricetinae; Cysteamine; In Vitro Techniques; Inactivation, Metabolic; Kineti | 1986 |
Increased hepatotoxicity of acetaminophen by concomitant administration of caffeine in the rat.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Caffeine; Chemical and Dr | 1985 |
Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in mice.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alanine Transaminase; Animals; Chemical and Dru | 1985 |
Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid | 1985 |
Acetaminophen liver injury: sequential changes in two biochemical indices of regeneration and their relationship to histologic alterations.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver; Liver Regeneration; Male; Nec | 1985 |
Additive protection of cimetidine and N-acetylcysteine treatment against acetaminophen-induced hepatic necrosis in the rat.
Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Cimetidine; Dose-Response Relationship, Drug; | 1985 |
Effects of ethanol ingestion on the hepatotoxicity and metabolism of paracetamol in mice.
Topics: Acetaminophen; Alcohol Drinking; Alcoholism; Animals; Chemical and Drug Induced Liver Injury; Cytoch | 1985 |
Effect of hepatic failure toxins on liver thymidine kinase activity and ornithine decarboxylase activity after massive necrosis with acetaminophen in the rat.
Topics: Acetaminophen; Animals; Caprylates; Chemical and Drug Induced Liver Injury; Disulfides; Hepatectomy; | 1985 |
Acetaminophen hepatotoxicity in vivo is not accompanied by oxidant stress.
Topics: Acetaminophen; Animals; Bile; Glutathione; Liver; Male; Necrosis; Oxidation-Reduction; Rats; Rats, I | 1985 |
Letter: Treatment of acute paracetamol hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver; Liver Circulation; Microscopy | 1973 |
Letter: Paracetamol toxicity and propranolol.
Topics: Acetaminophen; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Dogs; Drug Antago | 1973 |
Effects of mepyramine, promethazine, and hydrocortisone on paracetamol-induced hepatic necrosis in the rat.
Topics: Acetaminophen; Animals; Benzyl Compounds; Chemical and Drug Induced Liver Injury; Ethylenediamines; | 1973 |
Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.
Topics: Acetaminophen; Animals; Caffeine; Carbon Monoxide; Carbon Radioisotopes; Chemical and Drug Induced L | 1973 |
Treatment of acute paracetamol poisoning.
Topics: Acetaminophen; Adult; Blood Protein Disorders; Brain Edema; Chemical and Drug Induced Liver Injury; | 1968 |
Commentary. A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. I. Correlation of changes in covalent binding of reactivity metabolites with changes in the incidence and severity of toxicity.
Topics: Acetaminophen; Animals; Autoradiography; Benzene Derivatives; Carbon Tetrachloride Poisoning; Carcin | 1974 |
A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. II. Alterations in the kinetics of covalent binding.
Topics: Acetaminophen; Animals; Benzene Derivatives; Chemical Phenomena; Chemistry; Cricetinae; Diffusion; E | 1974 |
Abnormal drug metabolism after barbiturate and paracetamol overdose.
Topics: Acetaminophen; Adult; Aged; Alanine Transaminase; Amobarbital; Antipyrine; Barbiturates; Bilirubin; | 1974 |
Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cricetinae; Depression, Chemical; Gl | 1974 |
Paracetamol overdose: a plan of management.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Cardiomyopathies; Chemical and Drug Induced Liver Injury; | 1974 |
Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Animals; Cricetinae; Depression, Chemical; Glutathione; Liver; Mass S | 1974 |
[Liver damage following paracetamole poisoning].
Topics: Acetaminophen; Acute Kidney Injury; Animals; Autopsy; Blood Sedimentation; Chemical and Drug Induced | 1972 |
Protection of rats against the hepatotoxic effect of paracetamol.
Topics: Acetaminophen; Administration, Oral; Animals; Cysteamine; Cytochrome P-450 Enzyme System; Drug Inter | 1974 |
Gross paracetamol overdosage with recovery.
Topics: Acetaminophen; Adult; Bilirubin; Chemical and Drug Induced Liver Injury; Humans; Male; Necrosis; Pre | 1973 |
Potentiation by previous drug therapy of hepatotoxicity following paracetamol overdosage.
Topics: Acetaminophen; Adolescent; Adult; Amobarbital; Aspartate Aminotransferases; Bilirubin; Chemical and | 1973 |
Acute acetaminophen poisoning.
Topics: Acetaminophen; Bilirubin; Blood Coagulation Disorders; Cardiomyopathies; Diuresis; Humans; Hypoglyce | 1973 |
Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cobalt; Dose-Response Relationship, | 1973 |
Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo.
Topics: Acetaminophen; Animals; Carbon Radioisotopes; Cell Nucleus; Chemical and Drug Induced Liver Injury; | 1973 |
Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione.
Topics: Acetaminophen; Animals; Autoradiography; Chemical and Drug Induced Liver Injury; Cysteine; Glutathio | 1973 |
Histological appearances in fulminant hepatic failure with reference to aetiology, time of survival and role of immunological processes.
Topics: Acetaminophen; Adolescent; Adult; Aged; Cell Nucleus; Chemical and Drug Induced Liver Injury; Haloth | 1973 |
The effects of hepatic and renal damage on paracetamol metabolism and excretion following overdosage. A pharmacokinetic study.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Alanine Transaminase; Aspartate Aminotr | 1973 |
The effect of phenobarbitone pretreatment on paracetamol toxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 1973 |
Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen.
Topics: Acetaminophen; Animals; Binding Sites; Chemical and Drug Induced Liver Injury; Cricetinae; Glutathio | 1974 |
Circuitry and technique of extracorporeal porcine liver perfusion for the treatment of hepatic coma.
Topics: Acetaminophen; Acute Disease; Animals; Extracorporeal Circulation; Fatty Liver; Hepatic Encephalopat | 1971 |
Extracorporeal perfusion of pig liver in the treatment of acute liver failure.
Topics: Acetaminophen; Adult; Animals; Bilirubin; Brain; Chemical and Drug Induced Liver Injury; Electroence | 1971 |
Acetaminophen-induced hepatic necrosis and renal failure.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Biopsy; Chemical and Drug Induced Liver Injury; Female; H | 1971 |
Acute myocardial necrosis in paracetamol poisoning.
Topics: Acetaminophen; Adult; Cardiomyopathies; Female; Humans; Necrosis; Pregnancy | 1971 |
[Paracetamol].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Necrosis | 1971 |
Experimental paracetamol-induced hepatic necrosis: a histopathological study.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytoplasmic Granules; Liver; Liver D | 1971 |
Acute myocardial necrosis in paracetamol poisoning.
Topics: Acetaminophen; Adolescent; Female; Heart Diseases; Humans; Necrosis | 1971 |
Liver necrosis and myocardiopathy following paracetamol overdosage.
Topics: Acetaminophen; Adult; Cardiomyopathies; Chemical and Drug Induced Liver Injury; Female; Humans; Live | 1968 |
Acute hepatic necrosis following an overdose of paracetamol.
Topics: Acetaminophen; Acute Disease; Acute Kidney Injury; Adult; Bilirubin; Blood Glucose; Chemical and Dru | 1969 |
Liver necrosis from paracetamol.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Male; Necrosis | 1966 |
Acute liver necrosis following overdose of paracetamol.
Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Hypoglycemia; Male; Ne | 1966 |
Liver necrosis from paracetamol.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Male; Necrosis; Organ Size; Phenacet | 1966 |