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acetaminophen and Necrosis

acetaminophen has been researched along with Necrosis in 423 studies

Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"Although considered safe at therapeutic doses, at higher doses, acetaminophen produces a centrilobular hepatic necrosis that can be fatal."8.86Mechanisms of acetaminophen-induced liver necrosis. ( Hinson, JA; James, LP; Roberts, DW, 2010)
"Prevention of liver failure arising from accidental or deliberate paracetamol (acetaminophen [APAP]) overdose remains a vexed health problem despite well-publicized guidelines for its early detection and treatment."8.31Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver. ( Alabbas, SY; Begun, J; Davies, J; Florin, TH; Giri, R; Oancea, I; Schreibner, V, 2023)
"Acetaminophen (APAP) overdose-induced acute liver injury (AILI) is a significant clinical problem worldwide, the hepatotoxicity mechanisms are well elucidated, but the factors involved in the necrosis and repair still remain to be investigated."7.91Integrative proteomics and immunochemistry analysis of the factors in the necrosis and repair in acetaminophen-induced acute liver injury in mice. ( Dai, G; Feng, Q; Liang, C; Liu, L; Luo, L; Sun, J; Xia, W; Yang, J; Zhao, N, 2019)
"The degree of liver inflammation and hepatocellular necrosis were significantly higher in HFGD fed animals after acetaminophen administration."7.78Susceptibility of rat non-alcoholic fatty liver to the acute toxic effect of acetaminophen. ( Cervinková, Z; Haňáčková, L; Kučera, O; Lotková, H; Podhola, M; Roušar, T; Staňková, P, 2012)
" Using a high-resolution and high-magnification multiphoton microscopic system, we recorded in living mice serial changes of acetaminophen (APAP)-induced hepatocyte necrosis in relevance to metabolism of a fluorogenic bile solute."7.77Apical membrane rupture and backward bile flooding in acetaminophen-induced hepatocyte necrosis. ( Chiou, LL; Dong, CY; Huang, GT; Lee, HS; Li, FC; Lin, CJ; Lo, SY; Lo, W; Sun, TL; Wang, SS, 2011)
" Hepatocyte apoptosis, necrosis, and innate immune activation have been defined as features of the toxicological response associated with the hepatotoxin acetaminophen (APAP)."7.75High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo. ( Antoine, DJ; Jenkins, RE; Kipar, A; Kitteringham, NR; Park, BK; Regan, SL; Sathish, JG; Williams, DP, 2009)
"A 28-year-old man with schizophrenia intentionally ingested a lethal dose of acetaminophen and an unknown quantity of ibuprofen."7.74Rhabdomyolysis and necrotic bowel after acetaminophen and ibuprofen overdose. ( Dunn, T; Katz, D; Nelson, H; Singh, G; Thomsen, D; Voigt, M; Whitaker, E, 2007)
"An overdose of acetaminophen (APAP) (N-acetyl-p-aminophenol) leads to hepatocellular necrosis induced by its metabolite N-acetyl-p-benzoquinone-imine, which is generated during the metabolic phase of liver intoxication."7.73Deoxyribonuclease 1 aggravates acetaminophen-induced liver necrosis in male CD-1 mice. ( Apostolov, EO; Basnakian, AG; Mannherz, HG; Napirei, M, 2006)
"The hypothesis that acetaminophen can reduce necrosis during myocardial infarction was tested in male dogs."7.72Acetaminophen and myocardial infarction in dogs. ( Golfetti, R; Merrill, GF; Rork, TH; Spiler, NM, 2004)
"This study of acetaminophen (AAP) hepatotoxicity examined whether some aspects of the highly integrated process of drug-induced toxicity involves apoptosis, in addition to necrosis in vivo; and if so, whether cholesteryl hemisuccinate (CS) pretreatment would selectively interfere with apoptotic or necrotic liver cell death."7.69Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment. ( Fariss, MW; Mumaw, VR; Raje, RR; Ray, SD, 1996)
"The relationship between serum aminotransferase levels and the acute hepatic necrosis induced by acetaminophen was studied in 24 male Wistar rats (220-265 g)."7.69Correlation between the severity of acute hepatic necrosis induced by acetaminophen and serum aminotransferase levels in fasted and sucrose-fed rats. ( Collares, EF; De-Santi-Neto, D; Hessel, G, 1996)
"Vascular congestion and liver swelling have long been recognized as features of the hepatotoxic effects of acetaminophen (AAP) in mice and rats and have been proposed as contributing factors to the eventual extent of necrosis produced."7.68Investigation of possible mechanisms of hepatic swelling and necrosis caused by acetaminophen in mice. ( Benzick, AE; Hansen, TN; Montgomery, CA; Smith, CV; Welty, SE, 1993)
" After 10 days of feeding acetaminophen was administered intraperitoneally in amounts known to induce liver necrosis (500 mg/kg)."7.67Protective action of 2(3)-tert-butyl-4-hydroxyanisole (BHA) on acetaminophen-induced liver necrosis in male A/J mice. ( Boroujerdi, M; Carlo, JR; Rosenbaum, SE, 1984)
"A 63-year-old man with acute psittacosis had severe hepatic damage after ingesting about 10 g of acetaminophen over a 48 hour period."7.66Severe hepatic damage after acetaminophen use in psittacosis. ( Davis, AM; Helms, CM; LaBrecque, DR; Mitros, FA; Wong, YW, 1983)
"A preliminary trial was conducted to determine if cimetidine would prevent acetaminophen-induced hepatic necrosis."7.66Prevention of acetaminophen-induced hepatic necrosis by cimetidine in mice. ( Donn, KH; Grisham, JW; Rudd, GD, 1981)
"In an attempt to elucidate the biochemical mechanism of acetaminophen-induced hepatic necrosis, the present study in hamsters was undertaken to evaluate the possible changes in lipid peroxidation and microsomal enzyme activities."7.66Experimental acetaminophen-induced hepatic necrosis: biochemical and electron microscopic study of cysteamine protection. ( Bhakthan, NM; Chiu, S, 1978)
"60 patients with paracetamol poisoning have been treated with intravenous cysteamine, L-methionine, or D-penicillamine and the incidence and severity of hepatic necrosis compared with those observed in 70 patients receiving supportive therapy only."7.65Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. ( Park, J; Prescott, LF; Proudfoot, AT; Smith, IJ; Sutherland, GR, 1976)
"Acetaminophen (APAP) is a widely used analgesic drug, which can cause severe liver injury after an overdose."6.66Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity. ( Jaeschke, H; Ramachandran, A, 2020)
"Coenzyme Q10 (CoQ10) which acts as an electron transporter in the mitochondrial respiratory chain has many beneficial effects on liver diseases."5.62CoQ10 Promotes Resolution of Necrosis and Liver Regeneration After Acetaminophen-Induced Liver Injury. ( Chen, S; Chen, X; Fang, W; He, T; Tang, Y; Zhang, P, 2021)
"Acetaminophen (APAP) is a known hepatotoxin predictably causing intrinsic DILI."5.62Boldine treatment protects acetaminophen-induced liver inflammation and acute hepatic necrosis in mice. ( Ezhilarasan, D; Raghunandhakumar, S, 2021)
" HMGB1 acts as a danger-associated molecular patterns during this toxic process but the mechanisms of action and targeted cells are incompletely defined."5.56New insights in acetaminophen toxicity: HMGB1 contributes by itself to amplify hepatocyte necrosis in vitro through the TLR4-TRIF-RIPK3 axis. ( Devière, J; Dressen, C; Gustot, T; Leclercq, I; Lemmers, A; Liefferinckx, C; Minsart, C; Moreau, R; Quertinmont, E, 2020)
"Acetaminophen (APAP) is a common antipyretic and analgesic drug, but its overdose can induce acute liver failure with lack of effective therapies."5.56Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via upregulation of heme oxygenase-1 expression. ( Chen, Y; He, Z; Jiang, R; Kuang, G; Wan, J; Ye, D; Zhang, L, 2020)
"Acetaminophen (APAP) is a readily available and safe painkiller."5.46Fast food diet-induced non-alcoholic fatty liver disease exerts early protective effect against acetaminophen intoxication in mice. ( Choi, D; Kim, JY; Kim, TH; Koo, SH; Lee, JH, 2017)
"Patient 1 was admitted with acute liver failure following acetaminophen intoxication."5.35Apoptosis versus necrosis rate as a predictor in acute liver failure following acetaminophen intoxication compared with acute-on-chronic liver failure. ( Bechmann, LP; Canbay, A; Gerken, G; Jochum, C; Marquitan, G; Saner, F, 2008)
"Acetaminophen (paracetamol) is an analgesic-antipyretic drug virtually devoid of typical anti-inflammatory activity and hence free of some of the side-effects of aspirin and related agents (e."5.32Long-term acetaminophen (paracetamol) treatment causes liver and kidney ultra-structural changes during rat pregnancy. ( Kulay, L; Neto, JA; Oliveira-Filho, RM; Simões, MJ; Soares, JM, 2004)
"Hypothyroidism was induced by methimazole, propylthiouracil, or surgical thyroidectomy and confirmed by elevated serum levels of TSH."5.30Hypothyroidism protects rat liver from acetaminophen hepatotoxicity. ( Aeed, H; Avni, Y; Bruck, R; Frenkel, D; Halpern, Z; Matas, Z; Oren, R; Papa, M; Shirin, H; Zaidel, L, 1999)
" These data cannot support the concept that induction of cytochrome P-450 leads to greater formation of the hypothetical toxic metabolite of acetaminophen, or that induction enhances its hepatotoxicity, in the rat."5.27Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat. ( Lerche, A; Pedersen, NT; Poulsen, HE, 1985)
"Although considered safe at therapeutic doses, at higher doses, acetaminophen produces a centrilobular hepatic necrosis that can be fatal."4.86Mechanisms of acetaminophen-induced liver necrosis. ( Hinson, JA; James, LP; Roberts, DW, 2010)
"Prevention of liver failure arising from accidental or deliberate paracetamol (acetaminophen [APAP]) overdose remains a vexed health problem despite well-publicized guidelines for its early detection and treatment."4.31Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver. ( Alabbas, SY; Begun, J; Davies, J; Florin, TH; Giri, R; Oancea, I; Schreibner, V, 2023)
"Acetaminophen (APAP) overdose can cause hepatotoxicity by inducing mitochondrial damage and subsequent necrosis in hepatocytes."3.91Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury: possible involvement of ER stress and S6K1 activation. ( Bae, SH; Cho, Y; Jo, Y; Kim, HS; Kim, JH; Lee, B; Lee, DH; Lee, YH; Lee, YS; Nam, KT; Park, JS, 2019)
"Acetaminophen (APAP) overdose-induced acute liver injury (AILI) is a significant clinical problem worldwide, the hepatotoxicity mechanisms are well elucidated, but the factors involved in the necrosis and repair still remain to be investigated."3.91Integrative proteomics and immunochemistry analysis of the factors in the necrosis and repair in acetaminophen-induced acute liver injury in mice. ( Dai, G; Feng, Q; Liang, C; Liu, L; Luo, L; Sun, J; Xia, W; Yang, J; Zhao, N, 2019)
" We induced in vivo hepatocyte necrosis and apoptosis in mice deficient in DNase1L3 (also named DNase γ) and/or caspase-activated DNase (CAD) genes with acetaminophen overdose and anti-Fas antibody treatments."3.91Cell-free DNA in blood circulation is generated by DNase1L3 and caspase-activated DNase. ( Mizuta, R; Takada, S; Watanabe, T, 2019)
" N-acetyl-p-aminophenol (APAP), commonly known as acetaminophen, generates excessive oxidative stress and triggers hepatocyte cell death, exemplified by regulated necrosis."3.88Exogenous recombinant human thioredoxin-1 prevents acetaminophen-induced liver injury by scavenging oxidative stressors, restoring the thioredoxin-1 system and inhibiting receptor interacting protein-3 overexpression. ( Jeon, BS; Lee, BW; Yoon, BI, 2018)
"Acetaminophen (APAP) overdose induces severe oxidative stress followed by hepatocyte apoptosis/necrosis."3.85Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress. ( Aoyama, T; Arai, K; Ikejima, K; Kon, K; Kusama, H; Uchiyama, A; Watanabe, S; Yamashina, S, 2017)
" Liver histology showed more intense centrilobular necrosis in splenectomized group in comparison to the others, suggesting a protective role of spleen in acetaminophen-induced liver injury."3.85Autotransplantation of Spleen Mitigates Drug-Induced Liver Damage in Splenectomized Mice. ( Almeida, CS; de Oliveira, EE; de Paoli, F; Figueiredo, BBM; Grunewald, STF; Mendonça, ACP; Rezende, AB; Teixeira, HC, 2017)
" Acetaminophen is a commonly used antipyretic agent, which in high doses, causes uremia and used for experimentally induction of kidney disease."3.81Therapeutic potential of different commercially available synbiotic on acetaminophen-induced uremic rats. ( Das, K; Mahapatra, SD; Mahapatra, TD; Mandal, A; Mandal, S; Mondal, KC; Nandi, DK; Patra, A; Paul, T; Roy, S, 2015)
"Although necrosis in the acetaminophen (APAP) model is known to be regulated by c-Jun NH2-terminal kinase (JNK) through interaction with mitochondria, the role of necroptosis through receptor-interacting proteins 1 and 3 (RIPK1 and RIPK3) has also been suggested."3.81Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis. ( Dara, L; Gaarde, W; Han, D; Johnson, H; Kaplowitz, N; Suda, J; Win, S, 2015)
" A 55-year-old female was admitted to the burn unit (West Penn Burn Center, Western Pennsylvania Hospital, Pittsburgh, PA) after she initially presented with infection and cellulitis to her bilateral upper extremities 3 weeks after intravenously injecting herself with crushed oxycodone/acetaminophen."3.81Subcutaneous Injection of Percocet: A Case of Severe Soft Tissue Loss. ( Aballay, AM; Abboud, C; Baskin, SM; Chen, W; Kelly, RW; Tolchin, E, 2015)
" After acetaminophen intoxication, necrosis was significantly increased in TAFI-/- mice at 24 hours (h) after injection."3.79TAFI deficiency promotes liver damage in murine models of liver failure through defective down-regulation of hepatic inflammation. ( Adelmeijer, J; Hugenholtz, GC; Lisman, T; Meijers, JC; Porte, RJ, 2013)
"Inappropriate use of acetaminophen (APAP) can lead to morbidity and mortality secondary to hepatic necrosis."3.79Korean red ginseng extract prevents APAP-induced hepatotoxicity through metabolic enzyme regulation: the role of ginsenoside Rg3, a protopanaxadiol. ( Cho, MK; Gum, SI, 2013)
"The degree of liver inflammation and hepatocellular necrosis were significantly higher in HFGD fed animals after acetaminophen administration."3.78Susceptibility of rat non-alcoholic fatty liver to the acute toxic effect of acetaminophen. ( Cervinková, Z; Haňáčková, L; Kučera, O; Lotková, H; Podhola, M; Roušar, T; Staňková, P, 2012)
"Full length keratin-18 (FL-K18) and High Mobility Group Box-1 (HMGB1) represent circulating indicators of necrosis during acetaminophen (APAP) hepatotoxicity in vivo."3.78RETRACTED: Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity. ( Antoine, DJ; Craig, DG; Dear, JW; Jaeschke, H; Jenkins, RE; McGill, MR; Park, BK; Sharpe, MR; Simpson, KJ; Williams, DP, 2012)
" Ozone therapy (OT) is shown to reduce inflammation and necrosis in several entities."3.78The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury. ( Akgul, EO; Cakir, E; Cayci, T; Demirbag, S; Eyi, YE; Gul, H; Kaldirim, U; Korkmaz, A; Macit, E; Oter, S; Ozler, M; Oztas, E; Topal, T; Toygar, M; Uysal, B; Yaman, H; Yildirim, AO, 2012)
" Acetaminophen is a commonly used analgesic and antipyretic agent which, at high doses, causes liver and kidney necrosis in man and animals."3.77Evaluation of phytoconstituents and anti-nephrotoxic and antioxidant activities of Monochoria vaginalis. ( Kumar, BS; Kumar, RP; Palani, S; Raja, S; Selvaraj, R, 2011)
" Using a high-resolution and high-magnification multiphoton microscopic system, we recorded in living mice serial changes of acetaminophen (APAP)-induced hepatocyte necrosis in relevance to metabolism of a fluorogenic bile solute."3.77Apical membrane rupture and backward bile flooding in acetaminophen-induced hepatocyte necrosis. ( Chiou, LL; Dong, CY; Huang, GT; Lee, HS; Li, FC; Lin, CJ; Lo, SY; Lo, W; Sun, TL; Wang, SS, 2011)
"Recently, it was reported that the intraperitoneal administration of 30 mg/kg/day troglitazone to heterozygous superoxide dismutase 2 gene knockout (Sod2+/-) mice for twenty-eight days caused liver injury, manifested by increased serum ALT activity and hepatic necrosis."3.75Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen. ( Ando, Y; Arakawa, S; Fujimoto, K; Ito, K; Kumagai, K; Manabe, S; Oda, S; Yamoto, T, 2009)
" As a result, pretreated with ASE prior to the administration of APAP significantly prevented the increases of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and tumor necrosis factor-alpha (TNF-alpha) levels in serum, and glutathione (GSH) depletion, malondialdehyde (MDA) accumulation in liver tissue."3.75Protective Effects of the Supernatant of Ethanol Eluate from Artemisia sacrorum Ledeb. against Acetaminophen-Induced Liver Injury in Mice [corrected]. ( Jin, GZ; Piao, GC; Yuan, HD, 2009)
" We utilized acetaminophen (APAP) as a model hepatotoxicant that gives a multifocal pattern of necrosis following toxic doses."3.74Gene expression analysis offers unique advantages to histopathology in liver biopsy evaluations. ( Boorman, GA; Flagler, ND; Foley, JF; Heinloth, AN; Paules, RS, 2007)
"A 28-year-old man with schizophrenia intentionally ingested a lethal dose of acetaminophen and an unknown quantity of ibuprofen."3.74Rhabdomyolysis and necrotic bowel after acetaminophen and ibuprofen overdose. ( Dunn, T; Katz, D; Nelson, H; Singh, G; Thomsen, D; Voigt, M; Whitaker, E, 2007)
" One from a heart disease study and another from acetaminophen (an analgesic) exposure in rat liver that causes centrilobular necrosis."3.74Simultaneous clustering of gene expression data with clinical chemistry and pathological evaluations reveals phenotypic prototypes. ( Bushel, PR; Gibson, G; Wolfinger, RD, 2007)
" As model toxic compounds lipopolysaccharide (LPS, inducing inflammation), paracetamol (necrosis), carbon tetrachloride (CCl(4), fibrosis and necrosis) and gliotoxin (apoptosis) were used."3.74Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity. ( Bauerschmidt, S; Draaisma, AL; Elferink, MG; Groothuis, GM; Merema, MT; Olinga, P; Polman, J; Schoonen, WG, 2008)
" Adult Sprague-Dawley rats treated with acetaminophen or D-galactosamine (GalN) showed dose- and time-dependent histomorphological changes and TUNEL staining in liver consistent with hepatocellular necrosis, apoptosis and inflammation up to 72 h."3.74Cytochrome c: a non-invasive biomarker of drug-induced liver injury. ( Adeyemo, O; Hanig, JP; Knapton, A; Miller, TJ; Noory, L; Weaver, J, 2008)
"The results indicate that WLP-S-10 is a novel potential compound against acetaminophen-induced acute liver failure in mice, and its active mechanism is mainly related to protection against necrosis and apoptosis of hepatocytes through inhibition of mitochondrial energy (ATP) depletion and AIF and cytochrome C release."3.74Protection by bicyclol derivatives against acetaminophen-induced acute liver failure in mice and its active mechanism. ( Hou, Y; Li, L; Liu, G; Tong, Y; Wei, H; Wu, L; Wu, S, 2008)
"The acetaminophen (APAP)-induced hepatic centrilobular necrosis is preceded by hepatic microcirculatory dysfunction including the infiltration of erythrocytes into the space of Disse."3.73Inhibition of matrix metalloproteinases minimizes hepatic microvascular injury in response to acetaminophen in mice. ( Abril, ER; Bethea, NW; Ito, Y; McCuskey, RS, 2005)
"An overdose of acetaminophen (APAP) (N-acetyl-p-aminophenol) leads to hepatocellular necrosis induced by its metabolite N-acetyl-p-benzoquinone-imine, which is generated during the metabolic phase of liver intoxication."3.73Deoxyribonuclease 1 aggravates acetaminophen-induced liver necrosis in male CD-1 mice. ( Apostolov, EO; Basnakian, AG; Mannherz, HG; Napirei, M, 2006)
" Similarly, Fah(-/-) animals with liver injury were also resistant to apoptosis induced by the Fas ligand Jo-2 and to necrosis-like cell death induced by acetaminophen (APAP)."3.72Chronic liver disease in murine hereditary tyrosinemia type 1 induces resistance to cell death. ( Al-Dhalimy, M; Finegold, M; Grompe, M; Groopman, J; Iordanov, MS; Ou, CN; Ryabinina, O; van Den Berg, IE; Vogel, A, 2004)
"The hypothesis that acetaminophen can reduce necrosis during myocardial infarction was tested in male dogs."3.72Acetaminophen and myocardial infarction in dogs. ( Golfetti, R; Merrill, GF; Rork, TH; Spiler, NM, 2004)
" However, careful comparison of transgenic and nontransgenic mice revealed two phenotypic differences: mDuffy-transgenic mice exhibited a diminished angiogenic response to MIP-2 in the corneal micropocket assay, and mDuffy-transgenic mice exhibited enhanced hepatocellular toxicity and necrosis as compared with nontransgenic littermates in response to overdose of acetaminophen (APAP; 400 mg/kg body weight)."3.71Potential role for Duffy antigen chemokine-binding protein in angiogenesis and maintenance of homeostasis in response to stress. ( Chen, TS; Daniel, TO; Du, J; Horton, LW; Liu, H; Luan, J; Nanney, LB; Peiper, S; Richmond, A; Strieter, RM; Yu, Y, 2002)
"The effect of reduced glutathione (GSH) depletion by acetaminophen (APAP), diethylmaleate (DEM), or phorone on the mode of cell death and susceptibility to tumor necrosis factor (TNF)-induced cell death was studied in cultured mouse hepatocytes."3.71Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes. ( Feng, G; Kaplowitz, N; Matsumaru, K; Nagai, H, 2002)
"Hepatotoxic doses of acetaminophen to mice produce not only acetaminophen-protein adducts in the centrilobular cells of the liver, but nitrotyrosine-protein adducts in the same cells, the site of the necrosis."3.70Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species. ( Hinson, JA; Mayeux, PR; Michael, SL; Niesman, MR; Pumford, NR, 1999)
"The hepatic centrilobular necrosis produced by the analgesic/antipyretic acetaminophen correlates with metabolic activation of the drug leading to its covalent binding to protein."3.70Western blot analysis for nitrotyrosine protein adducts in livers of saline-treated and acetaminophen-treated mice. ( Ault, SG; Hinson, JA; Michael, SL; Pumford, NR, 2000)
"The mechanism(s) of liver damage initiated by ingestion of toxic components of thermally oxidized lipids was compared in a rat model with the documented mechanisms of hepatic failure and necrosis initiated by acetaminophen."3.69Comparison of thermally oxidized lipids and acetaminophen with concurrent consumption of ethanol as inducers of liver cirrhosis. ( Fouad, FM; Mamer, OA; Shahidi, F, 1995)
"A case of fatal paracetamol (acetaminophen) poisoning in a 26-year-old woman who developed liver necrosis is described."3.69[A case of paracetamol retard poisoning with fatal outcome]. ( Lystbaek, BB; Nørregaard, P, 1995)
"Administration of hepatotoxic doses of acetaminophen (APAP) to mice results in necrosis, not only of liver cells but of renal proximal tubules and bronchiolar and olfactory epithelium."3.69Immunohistochemical localization of acetaminophen in target tissues of the CD-1 mouse: correspondence of covalent binding with toxicity. ( Cartun, RW; Cohen, SD; Hart, SG; Khairallah, EA; Wyand, DS, 1995)
"We have analysed Kupffer cell and 'activated' perisinusoidal cell populations in liver biopsies from patients with paracetamol (acetaminophen)-induced hepatic necrosis of varying degrees of severity."3.69Non-parenchymal cell responses in paracetamol (acetaminophen)-induced liver injury. ( Burt, AD; Hines, JE; James, OF; Mathew, J, 1994)
"When administered four hours after a toxic dose of acetaminophen, 4-methylpyrazole significantly inhibits hepatotoxicity in the rat, as reflected by lower levels of serum transaminases and lesser degrees of hepatic necrosis."3.694-Methylpyrazole blocks acetaminophen hepatotoxicity in the rat. ( Baevsky, RH; Brennan, RJ; DelVecchio, JA; Lefevre, R; Mankes, RF; Raccio-Robak, N; Zink, BJ, 1994)
"This study of acetaminophen (AAP) hepatotoxicity examined whether some aspects of the highly integrated process of drug-induced toxicity involves apoptosis, in addition to necrosis in vivo; and if so, whether cholesteryl hemisuccinate (CS) pretreatment would selectively interfere with apoptotic or necrotic liver cell death."3.69Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment. ( Fariss, MW; Mumaw, VR; Raje, RR; Ray, SD, 1996)
" An abdominal enhanced CT scan revealed a wedge-shaped region of devitalised liver with associated free intraperitoneal fluid, consistent with a traumatic lesion but due to necrosis secondary to acetaminophen toxicity."3.69Hepatic necrosis masquerading as trauma. ( Anderson, B; Cluroe, A; Duncan, D, 1997)
"The relationship between serum aminotransferase levels and the acute hepatic necrosis induced by acetaminophen was studied in 24 male Wistar rats (220-265 g)."3.69Correlation between the severity of acute hepatic necrosis induced by acetaminophen and serum aminotransferase levels in fasted and sucrose-fed rats. ( Collares, EF; De-Santi-Neto, D; Hessel, G, 1996)
"Vascular congestion and liver swelling have long been recognized as features of the hepatotoxic effects of acetaminophen (AAP) in mice and rats and have been proposed as contributing factors to the eventual extent of necrosis produced."3.68Investigation of possible mechanisms of hepatic swelling and necrosis caused by acetaminophen in mice. ( Benzick, AE; Hansen, TN; Montgomery, CA; Smith, CV; Welty, SE, 1993)
" The objective of the present investigation was to study some of the possible mechanisms involved in the protective effect of sucrose ingestion against liver necrosis induced by acetaminophen."3.68Cytochrome P450 and glutathione in the liver of rats under exclusive sucrose ingestion. ( Martinelli, AL; Meneghelli, UG; Zucoloto, S, 1993)
"Ca2+ accumulates in the nucleus and DNA undergoes enzymatic cleavage into internucleosome-length fragments before acetaminophen and dimethylnitrosamine produce hepatic necrosis in vivo and toxic cell death in vitro."3.68Ca2+ antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen. ( Corcoran, GB; Gurule, MW; Kamendulis, LM; Ray, SD; Yorkin, RD, 1993)
" After 10 days of feeding acetaminophen was administered intraperitoneally in amounts known to induce liver necrosis (500 mg/kg)."3.67Protective action of 2(3)-tert-butyl-4-hydroxyanisole (BHA) on acetaminophen-induced liver necrosis in male A/J mice. ( Boroujerdi, M; Carlo, JR; Rosenbaum, SE, 1984)
"We report a case of fulminant hepatic necrosis occurring in the setting of acetaminophen overdose and chronic alcohol use."3.67Long-term sequellae of acetaminophen-associated fulminant hepatic failure: relevance of early histology. ( Baeg, NJ; Bodenheimer, HC; Burchard, K, 1988)
"Acetaminophen is a common drug used in pregnancy."3.67Maternal acetaminophen overdose at 15 weeks of gestation. ( Gabbe, SG; Landon, MB; Ludmir, J; Main, DM, 1986)
"A 63-year-old man with acute psittacosis had severe hepatic damage after ingesting about 10 g of acetaminophen over a 48 hour period."3.66Severe hepatic damage after acetaminophen use in psittacosis. ( Davis, AM; Helms, CM; LaBrecque, DR; Mitros, FA; Wong, YW, 1983)
"Both phenacetin and paracetamol produce acute centrilobular liver necrosis in the homozygous Gunn rat."3.66Hepatotoxicity of phenacetin and paracetamol in the Gunn rat. ( Calder, IC; Hart, SJ; Smail, MC; Tange, JD, 1981)
" Acetylcysteine prevents liver necrosis caused by acetaminophen, and some possible mechanisms are discussed."3.66An integrated approach to the study of chemically reactive metabolites of acetaminophen. ( Gillette, JR, 1981)
"In an attempt to elucidate the biochemical mechanism of acetaminophen-induced hepatic necrosis, the present study in hamsters was undertaken to evaluate the possible changes in lipid peroxidation and microsomal enzyme activities."3.66Experimental acetaminophen-induced hepatic necrosis: biochemical and electron microscopic study of cysteamine protection. ( Bhakthan, NM; Chiu, S, 1978)
"60 patients with paracetamol poisoning have been treated with intravenous cysteamine, L-methionine, or D-penicillamine and the incidence and severity of hepatic necrosis compared with those observed in 70 patients receiving supportive therapy only."3.65Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. ( Park, J; Prescott, LF; Proudfoot, AT; Smith, IJ; Sutherland, GR, 1976)
"Experimental hepatic necrosis was induced in phenobarbital pretreated rats by means of the intraperitoneal administration of an acetaminophen-dimethyl sulfixide (DMSO) mixture."3.65Experimental hepatic injury: the sequential changes in drug metabolizing enzyme activities after administration of acetaminophen. ( Hart, FE; Willson, RA, 1977)
"Drug-metabolizing capacity has been assessed by serial measurements of the plasma antipyrine half life in 11 patients with severe barbiturate intoxication and in 17 patients with acute hepatic necrosis due to paracetamol overdosage."3.65Abnormal drug metabolism after barbiturate and paracetamol overdose. ( Forrest, JA; Prescott, LF; Roscoe, P; Stevenson, IH, 1974)
"Acetaminophen (APAP) is a widely used analgesic drug, which can cause severe liver injury after an overdose."2.66Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity. ( Jaeschke, H; Ramachandran, A, 2020)
"Necrosis is typically the consequence of acute metabolic perturbation with ATP depletion as occurs in ischemia/reperfusion and acute drug-induced hepatotoxicity."2.43Apoptosis and necrosis in the liver: a tale of two deaths? ( Gores, GJ; Lemasters, JJ; Malhi, H, 2006)
"Acetaminophen has become a very popular over-the-counter analgesic in some countries and as a result it is used increasingly as an agent for self-poisoning."2.36The treatment of acetaminophen poisoning. ( Critchley, JA; Prescott, LF, 1983)
"Pretreatment with nicorandil reduced serum levels of aminotransferases, bilirubin, GGT and LDH, and increased serum level of albumin."1.91Hepatoprotective effect of nicorandil against acetaminophen-induced oxidative stress and hepatotoxicity in mice via modulating NO synthesis. ( El-Kashef, DH; Sharawy, MH, 2023)
"Anisomycin and SP600125 were used as JNK activator and inhibitor, respectively, and NAC served as a positive control."1.91Fluorofenidone protects against acute liver failure in mice by regulating MKK4/JNK pathway. ( Gu, L; He, X; Hu, G; Huang, H; Li, S; Liu, X; Ma, R; Meng, J; Peng, Y; Peng, Z; Tang, J; Tao, L; Xie, Y; Yang, H; Yang, X; Zhang, Y, 2023)
"Leonurine (Leo) is a natural alkaloid isolated from the herb Leonurus japonicus Houtt."1.91Leonurine alleviates acetaminophen-induced acute liver injury by regulating the PI3K/AKT signaling pathway in mice. ( Chen, Y; Di, S; Huang, X; Wang, Y; Yu, Y; Zhou, S, 2023)
"Rosiglitazone pretreatment can alleviate APAP-induced ALI by suppressing three branches of ERS signaling."1.72Rosiglitazone Protects against Acetaminophen-Induced Acute Liver Injury by Inhibiting Multiple Endoplasmic Reticulum Stress Pathways. ( Cao, Y; He, W; Huang, J; Li, X; Wang, J, 2022)
"Coenzyme Q10 (CoQ10) which acts as an electron transporter in the mitochondrial respiratory chain has many beneficial effects on liver diseases."1.62CoQ10 Promotes Resolution of Necrosis and Liver Regeneration After Acetaminophen-Induced Liver Injury. ( Chen, S; Chen, X; Fang, W; He, T; Tang, Y; Zhang, P, 2021)
"Acetaminophen (APAP) is a known hepatotoxin predictably causing intrinsic DILI."1.62Boldine treatment protects acetaminophen-induced liver inflammation and acute hepatic necrosis in mice. ( Ezhilarasan, D; Raghunandhakumar, S, 2021)
" HMGB1 acts as a danger-associated molecular patterns during this toxic process but the mechanisms of action and targeted cells are incompletely defined."1.56New insights in acetaminophen toxicity: HMGB1 contributes by itself to amplify hepatocyte necrosis in vitro through the TLR4-TRIF-RIPK3 axis. ( Devière, J; Dressen, C; Gustot, T; Leclercq, I; Lemmers, A; Liefferinckx, C; Minsart, C; Moreau, R; Quertinmont, E, 2020)
"Acetaminophen (APAP) is a common antipyretic and analgesic drug, but its overdose can induce acute liver failure with lack of effective therapies."1.56Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via upregulation of heme oxygenase-1 expression. ( Chen, Y; He, Z; Jiang, R; Kuang, G; Wan, J; Ye, D; Zhang, L, 2020)
" As herbal preparations may interact with pharmaceutical drugs the following in vitro study was undertaken to determine whether the toxic effects of paracetamol on liver cell growth in culture would be exacerbated by the addition of psoralen, a furanocoumarin compound that is present in Psoralea corylifolia, a common Chinese herb."1.56Paracetamol (acetaminophen) hepatotoxicity increases in the presence of an added herbal compound. ( Britza, SM; Byard, RW; Musgrave, IF, 2020)
"Acetaminophen (APAP)-induced acute liver failure (ALF) is a life-threatening disease with only a few treatment options available."1.51Liver-specific Bid silencing inhibits APAP-induced cell death in mice. ( Dames, S; Kuhla, A; Maxa, M; Schaeper, U; Vollmar, B, 2019)
" Functional experiments showed that OPN deficiency protected against the APAP-induced liver injury by inhibiting the toxic APAP metabolism via reducing the expression of the cytochrome P450 family 2 subfamily E member 1 (CYP2E1)."1.51Metabolic modulation of acetaminophen-induced hepatotoxicity by osteopontin. ( Gu, J; Kong, X; Sun, X; Sun, Y; Tong, Y; Wang, C; Wang, K; Wen, Y; Wu, H; Xia, Q; Yu, C, 2019)
"Acute liver failure is a serious consequence of acetaminophen (APAP)-induced hepatotoxic liver injury with high rates of morbidity and mortality."1.51The TGFβ1 Receptor Antagonist GW788388 Reduces JNK Activation and Protects Against Acetaminophen Hepatotoxicity in Mice. ( DeMorrow, S; Frampton, G; Grant, S; Jefferson, B; McMillin, M; Petrescu, AD; Williams, E, 2019)
"Death commonly involved multiple substance use and abuse behaviours indicative of misuse and dependence."1.48Unintentional mortality associated with paracetamol and codeine preparations, with and without doxylamine, in Australia. ( Dobbin, M; Hopkins, RE; Pilgrim, JL, 2018)
"Acetaminophen (APAP) is a readily available and safe painkiller."1.46Fast food diet-induced non-alcoholic fatty liver disease exerts early protective effect against acetaminophen intoxication in mice. ( Choi, D; Kim, JY; Kim, TH; Koo, SH; Lee, JH, 2017)
"Hypoxic hepatitis is a clinical condition precipitated by prolonged periods of oxygen deprivation to the liver."1.46Plasma biomarkers to study mechanisms of liver injury in patients with hypoxic hepatitis. ( Antoine, DJ; Curry, SC; Jaeschke, H; Jenkins, RE; McGill, MR; Olson, JC; Sharpe, MR; Weemhoff, JL; Woolbright, BL, 2017)
"In ConA-induced autoimmune hepatitis, RIP3 deletion was protective, whereas RIP1 inhibition exacerbated disease, accelerated animal death, and was associated with increased hepatocyte apoptosis."1.42Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury. ( Avanzi, N; Barilla, R; Daley, D; Deutsch, M; Eisenthal, A; Graffeo, CS; Greco, S; Gulati, R; Levie, EM; Miller, G; Ochi, A; Pachter, HL; Pansari, M; Rokosh, R; Tippens, DM; Tomkötter, L; Torres-Hernandez, A; Van Heerden, E; Zambirinis, CP, 2015)
"Gap junctional intercellular communication (GJIC), by which glutathione (GSH) and inorganic ions are transmitted to neighboring cells, is recognized as being largely involved in toxic processes of chemicals."1.40Role of connexin 32 in acetaminophen toxicity in a knockout mice model. ( Arakawa, S; Igarashi, I; Kai, K; Maejima, T; Sanbuissho, A; Teranishi, M, 2014)
"Curcumin was administered for 7 successive days, while paracetamol was administered at day six of treatment."1.40Immunohistochemical and molecular study on the protective effect of curcumin against hepatic toxicity induced by paracetamol in Wistar rats. ( Abdo Nassan, M; Ismail, TA; Soliman, MM, 2014)
"APAP treatments caused necrosis in liver and accompanied by elevated liver PTX-3 levels after 48 h."1.39Pentraxin 3 as a potential biomarker of acetaminophen-induced liver injury. ( Agilli, M; Akgul, EO; Altinel, O; Aydin, FN; Aydin, I; Bilgi, C; Cakir, E; Cayci, T; Erbil, KM; Ersoz, N; Gulec, M; Isbilir, S; Kurt, YG; Onguru, O; Turker, T; Yaman, H; Yasar, M, 2013)
"Irreversible acute liver failure, defined as rise in prothrombin time >3 times normal, occurred 19."1.39A reproducible, clinically relevant, intensively managed, pig model of acute liver failure for testing of therapies aimed to prolong survival. ( Alibhai, H; Baker, LA; Chang, YM; Davies, NA; Jalan, R; L Priestnall, S; Leckie, PJ; Lee, KC; Mookerjee, RP; Palacios Jimenez, C; Stanzani, G, 2013)
"Acetaminophen (APAP) is a safe analgesic and antipyretic drug."1.38Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure. ( Amaral, SS; Avila, TV; Cara, DC; De Paula, AM; Leite, MF; Lima, BH; Lima, CX; Lopes, GA; Marques, PE; Melgaço, JG; Menezes, GB; Nogueira, LL; Oliveira, AG; Pinto, MA; Pires, DA; Russo, RC; Soriani, FM; Teixeira, MM, 2012)
" Mkp-1⁺/⁺ and Mkp-1⁻/⁻ mice were dosed ip with vehicle or acetaminophen at 300 mg/kg (for mechanistic studies) or 400 mg/kg (for survival studies)."1.38Mitogen-activated protein kinase phosphatase (Mkp)-1 protects mice against acetaminophen-induced hepatic injury. ( Liu, Y; Meng, X; Rogers, LK; Wancket, LM, 2012)
" Results show that rats administered with toxic doses (1000 mg/kg, 3000 mg/kg, 5000 mg/kg BW) of paracetamol exhibited significant increases in the levels of ALT, AST, γ- GT compared with controls."1.37Biochemical and histologic presentations of female Wistar rats administered with different doses of paracetamol/methionine. ( Adeniyi, FA; Iyanda, AA, 2011)
" Erdosteine prevented APAP-induced liver injury and toxic side effects probably through the antioxidant and radical scavenging effects of erdosteine."1.35Effects of erdosteine on acetaminophen-induced hepatotoxicity in rats. ( Duru, M; Helvaci, R; Kaya, H; Koc, A; Kozlu, T; Kuvandik, G; Nacar, A; Sogüt, S; Yonden, Z, 2008)
"Acetaminophen is a commonly used drug for the treatment of patients with common cold and influenza."1.35Phyllanthus urinaria extract attenuates acetaminophen induced hepatotoxicity: involvement of cytochrome P450 CYP2E1. ( Chan, AK; Chan, AS; Cheng, CH; Cheng, GY; Chui, CH; Fong, DW; Gambari, R; Hau, DK; Kan, CW; Kok, SH; Lai, PB; Lau, FY; Leung, AK; Tang, JC; Tong, CS; Wong, RS; Wong, WY; Yuen, MC; Zhu, GY, 2009)
"Acetaminophen (APAP) is safe at therapeutic levels but causes hepatotoxicity via N-acetyl-p-benzoquinone imine-induced oxidative stress upon overdose."1.35Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity. ( Cheng, J; Gonzalez, FJ; Idle, JR; Krausz, KW; Ma, X, 2009)
"However, acute renal failure, although less frequent, can lead to serious metabolic complications and require hemodialysis."1.35[Acute renal failure after acetaminophen poisoning: report of three cases]. ( Allaouchiche, B; Baillon, JJ; Ber, CE; Christin, F; Hayi-Slayman, D; Hengy, B; Page, M; Rimmelé, T, 2009)
"Patient 1 was admitted with acute liver failure following acetaminophen intoxication."1.35Apoptosis versus necrosis rate as a predictor in acute liver failure following acetaminophen intoxication compared with acute-on-chronic liver failure. ( Bechmann, LP; Canbay, A; Gerken, G; Jochum, C; Marquitan, G; Saner, F, 2008)
" The principal component analysis (PCA) of NMR or UPLC/MS spectra showed that metabolic changes observed in both acute and chronic dosing of acetaminophen were similar."1.35Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS. ( Beger, RD; Cantor, GH; Dragan, YP; Holland, RD; Schmitt, TC; Schnackenberg, LK; Sun, J, 2008)
"Acetaminophen (APAP) is a widely used analgesic and antipyretic drug that is safe at therapeutic doses but which can precipitate liver injury at high doses."1.34Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury. ( Boelsterli, UA; Goh, CW; Latchoumycandane, C; Ong, MM, 2007)
" The sensitivity of the proposed method to detect changes in the NMR spectra 24 and 48 h after single dosing was compared with histopathology and biochemical parameters in plasma and urine."1.34Sensitivity of (1)H NMR analysis of rat urine in relation to toxicometabonomics. Part I: dose-dependent toxic effects of bromobenzene and paracetamol. ( Horbach, GJ; Kloks, CP; Mellema, JR; Ploemen, JP; Schoonen, WG; Smit, MJ; Tas, AC; van Nesselrooij, JH; Vogels, JT; Zandberg, P; Zuylen, CT, 2007)
"Carbon tetrachloride treatment 24 h prior to a challenging dose of carbon tetrachloride or acetaminophen decreased the resulting hepatotoxicity both in male and female mice as determined by histopathological examination and increases in serum enzyme activities."1.34Hepatic injury induces contrasting response in liver and kidney to chemicals that are metabolically activated: role of male sex hormone. ( Jung, YS; Kim, SY; Kim, YC; Park, JH; Yim, HK, 2007)
"L-carnitine is a cofactor in the transfer of long-chain fatty acid allowing the beta-oxidation of fatty acid in the mitochondria."1.34Hepatoprotective effect of L-carnitine against acute acetaminophen toxicity in mice. ( Atakisi, O; Citil, M; Erginsoy, S; Karapehlivan, M; Kart, A; Tunca, R; Yapar, K, 2007)
" To determine the importance of reversible versus toxic events, N-acetylcysteine (NAC) was administered to mice either before APAP or 1, 2, or 4 h after APAP."1.32Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation. ( Hinson, JA; James, LP; Lamps, LW; McCullough, SS, 2003)
"Acetaminophen treatment of HepG2 cells caused oxidative damage and apoptosis."1.32N-acetylcysteine does not protect HepG2 cells against acetaminophen-induced apoptosis. ( Hirsh, M; Iancu, TC; Manov, I, 2004)
"Acetaminophen (paracetamol) is an analgesic-antipyretic drug virtually devoid of typical anti-inflammatory activity and hence free of some of the side-effects of aspirin and related agents (e."1.32Long-term acetaminophen (paracetamol) treatment causes liver and kidney ultra-structural changes during rat pregnancy. ( Kulay, L; Neto, JA; Oliveira-Filho, RM; Simões, MJ; Soares, JM, 2004)
"To understand the bioavailability and mechanistic pathways of cytoprotection by IH636 grape seed proanthocyanidin extract (GSPE, commercially known as ActiVin) a series of in vitro and in vivo studies were conducted."1.31Mechanistic pathways of antioxidant cytoprotection by a novel IH636 grape seed proanthocyanidin extract. ( Bagchi, D; Bagchi, M; Preuss, HG; Ray, SD; Stohs, SJ, 2002)
"Liver necrosis was produced by administering single dose of paracetamol (2 g/kg, p."1.31Effect of Azadirachta indica (Neem) leaf aqueous extract on paracetamol-induced liver damage in rats. ( Bhanwra, S; Khosla, P; Singh, J, 2000)
"Taurine (200 mg/kg) was given 12 h before, at the time of, and 1 or 2 h after acetaminophen injection."1.31Role of taurine in preventing acetaminophen-induced hepatic injury in the rat. ( Bouchier-Hayes, D; Kay, E; Redmond, HP; Wang, JH; Waters, E; Wu, QD, 2001)
" In conclusion, the administration of 4-MP and/or NAC after 4 h of administering toxic dose of acetaminophen, inhibits hepatotoxicity in rats."1.31Comparison of the therapeutic efficacy of 4-methylpyrazole and N-acetylcysteine on acetaminophen (paracetamol) hepatotoxicity in rats. ( Acar, HV; Cankir, Z; Cermik, H; Cinan, U; Danaci, M; Küçükardali, Y; Nalbant, S; Ozkan, S; Top, C, 2002)
" Thus, the protection against APAP toxicity afforded by deletion of both CYP2E1 and CYP1A2 likely reflects greatly diminished production of the toxic electrophile, NAPQI."1.30Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice. ( Bruno, MK; Buters, JT; Cohen, SD; Gonzalez, FJ; Lucas, AM; Stern, ST; Ward, JM; Zaher, H, 1998)
"Acetaminophen (APAP) is a common analgesic and antipyretic compound which, when administered in high doses, has been associated with significant morbidity and mortality, secondary to hepatic toxicity."1.30Role of neutrophils in hepatotoxicity induced by oral acetaminophen administration in rats. ( Kokoska, ER; Miller, TA; Nadig, DE; Smith, GS; Solomon, H; Tiniakos, DG, 1998)
"Hypothyroidism was induced by methimazole, propylthiouracil, or surgical thyroidectomy and confirmed by elevated serum levels of TSH."1.30Hypothyroidism protects rat liver from acetaminophen hepatotoxicity. ( Aeed, H; Avni, Y; Bruck, R; Frenkel, D; Halpern, Z; Matas, Z; Oren, R; Papa, M; Shirin, H; Zaidel, L, 1999)
"Rats treated with misoprostol before and after APAP administration showed reduced OCT and ALT levels at 36 hr of overdose (454 +/- 446 IU/liter and 2571 +/- 2944 IU/liter, respectively) compared to those without misoprostol treatment (1348 +/- 480 IU/liter and 6077 +/- 3025 IU/liter, respectively, P < 0."1.29Misoprostol protection against acetaminophen-induced hepatotoxicity in the rat. ( Andrews, FJ; Lim, SP; O'Brien, PE, 1994)
" Second, dose-response relationships for phenylpropanolamine and acetaminophen were such that increased toxicity was observed only when the interaction was sufficient to lower hepatic glutathione concentrations below a level regarded as critical in preventing acetaminophen-induced hepatotoxicity."1.29Phenylpropanolamine potentiation of acetaminophen-induced hepatotoxicity: evidence for a glutathione-dependent mechanism. ( Harbison, RD; James, RC; Roberts, SM, 1993)
"The necrosis is probably multifactorial in origin, with ischaemia and sepsis contributing factors."1.28Necrotizing myopathy in critically-ill patients. ( Bone, JM; Campbell, IT; Coakley, JH; Green, CJ; Griffiths, RD; Helliwell, TR; McClelland, P; Wagenmakers, AJ, 1991)
"The hepatotoxicity of acetaminophen (APAP) overdose depends on metabolic activation to a toxic reactive metabolite via hepatic mixed function oxidase."1.28Acetaminophen hepatotoxicity: is there a role for prostaglandin synthesis? ( Ben-Zvi, Z; Danon, A; Katz, S; Weissman-Teitellman, B, 1990)
"Using weanling mice of two different genetic strains we demonstrated a potentiation of the toxic effects of acetaminophen by prior infection with influenza B virus."1.27Potentiation of the toxic effects of acetaminophen in mice by concurrent infection with influenza B virus: a possible mechanism for human Reye's syndrome? ( Hudak, G; MacDonald, MG; McGrath, PP; McMartin, DN; Washington, GC, 1984)
"This augmented necrosis is averted by prolonged treatment with hyperbaric oxygen."1.27Effect of hyperoxia on liver necrosis induced by hepatotoxins. ( Marzella, L; Muhvich, K; Myers, RA, 1986)
" Oral dosage of the 3,5-dialkyl-substituted derivatives up to 6."1.27Paracetamol, 3-monoalkyl- and 3,5-dialkyl derivatives: comparison of their hepatotoxicity in mice. ( de Vries, J; Groot, EJ; van de Straat, R; Vermeulen, NP; Zijl, R, 1987)
" The operative status of the hepatic GSH conjugative system has an important influence on the rate of elimination of toxic APAP doses."1.27Time development of distribution and toxicity following single toxic APAP doses in male BOM:NMRI mice. ( Ingebrigtsen, K; Jansen, JH; Nafstad, I; Skoglund, LA, 1987)
" Since the major nontoxic pathway (glucuronide) and the toxic pathway (as measured by mercapturate) decreased to a similar extent, the data indicate that the anomalous lack of protection cannot be explained on the basis of altered metabolic disposition of the drug."1.27Anomalous susceptibility of the fasted hamster to acetaminophen hepatotoxicity. ( Jollow, DJ; Miller, MG; Price, VF, 1986)
" The depression of the nontoxic glucuronidation and sulfation pathways resulted in an increased proportion of the dose converted to the toxic metabolite and, hence, contributed to the potentiation of liver injury in fasted rats."1.27Mechanisms of fasting-induced potentiation of acetaminophen hepatotoxicity in the rat. ( Jollow, DJ; Miller, MG; Price, VF, 1987)
" Since cysteamine decreased both beta and the apparent rate constant for mercapturate formation (K'MA), the proportion of the dose of acetaminophen which is converted to the toxic metabolite (K'MA/beta) was not significantly decreased in the presence of cysteamine."1.27Acetaminophen hepatotoxicity: studies on the mechanism of cysteamine protection. ( Jollow, DJ; Miller, MG, 1986)
" These data cannot support the concept that induction of cytochrome P-450 leads to greater formation of the hypothetical toxic metabolite of acetaminophen, or that induction enhances its hepatotoxicity, in the rat."1.27Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat. ( Lerche, A; Pedersen, NT; Poulsen, HE, 1985)
"Four caffeine-treated rats had histologic evidence of acute myocardial infarction which was not found in any of the other rats."1.26Cardiovascular lesions in Sprague-Dawley rats induced by long-term treatment with caffeine. ( Johansson, S, 1981)
" A significant reduction in the LD50 was seen in the alcohol-pretreated mice, and correlations were noted between histological findings in the liver and the LD50 data."1.26Potentiation of acetaminophen hepatotoxicity by alcohol. ( Holtzman, JL; Kromhout, JP; McClain, CJ; Peterson, FJ, 1980)
"Metyrapone was effective in preventing death when given up to 2 h after acetaminophen administration."1.26Effectiveness of methyrapone in the treatment of acetaminophen toxicity in mice. ( Goldstein, M; Montes, M; Nelson, EB, 1980)
" The hallmark of severe (grade III) damage is centrizonal necrosis, for which there is probably a dosage threshold."1.26Evaluation of paracetamol-induced damage in liver biopsies. Acute changes and follow-up findings. ( Douglas, AP; Hamlyn, AN; James, OF; Lesna, M; Watson, AJ, 1976)
" The plasma half-life of the unchanged drug was significantly prolonged, and the ratio of the plasma concentrations of unchanged to conjugated paracetamol was significantly higher than in the patients without liver damage."1.25The effects of hepatic and renal damage on paracetamol metabolism and excretion following overdosage. A pharmacokinetic study. ( Prescott, LF; Wright, N, 1973)

Research

Studies (423)

TimeframeStudies, this research(%)All Research%
pre-1990145 (34.28)18.7374
1990's53 (12.53)18.2507
2000's84 (19.86)29.6817
2010's110 (26.00)24.3611
2020's31 (7.33)2.80

Authors

AuthorsStudies
Marques, PE2
Vandendriessche, S1
de Oliveira, THC1
Crijns, H1
Lopes, ME2
Blanter, M1
Schuermans, S1
Yu, K1
Poosti, F1
Vanheule, V1
Janssens, R1
Boff, D1
Kungl, AJ1
Menezes, GB3
Teixeira, MM2
Proost, P1
Chen, S1
Tang, Y2
Fang, W1
He, T1
Chen, X2
Zhang, P1
Cai, X1
Cai, H1
Wang, J3
Yang, Q1
Guan, J1
Deng, J1
Chen, Z1
Chen, D1
Zhao, X1
Xu, H1
Ren, H1
Liu, T1
Wang, Y4
Yang, D1
Yang, Z1
Nguyen, NT3
Umbaugh, DS2
Huang, EL1
Adelusi, OB2
Sanchez Guerrero, G1
Ramachandran, A14
Jaeschke, H34
Mao, X1
Wu, D1
Xu, N1
Zeng, J1
Jiang, Z1
Liu, Y4
Liang, H1
Samuvel, DJ1
Lemasters, JJ7
Wang, X1
Choo, YM1
Hamann, MT1
Zhong, Z1
Nakagaki, BN1
Mattos, MS1
Campolina-Silva, GH1
Meira, RO1
Paixão, PHM1
Oliveira, AG2
Faustino, LD1
Gonçalves, R1
El-Kashef, DH1
Sharawy, MH1
Akakpo, JY1
Jaeschke, MW1
Etemadi, Y1
Artigues, A1
Toerber, S1
Olivos, H1
Shrestha, B1
Midey, A1
Win, S3
Than, TA2
Kaplowitz, N6
Cao, Y1
He, W2
Li, X2
Huang, J1
Alabbas, SY1
Giri, R1
Oancea, I1
Davies, J1
Schreibner, V1
Florin, TH1
Begun, J1
Smith, S1
Sanchez-Guerrero, G1
Ishida, Y1
Zhang, S1
Kuninaka, Y1
Ishigami, A1
Nosaka, M1
Harie, I1
Kimura, A1
Mukaida, N1
Kondo, T1
Gu, L1
He, X1
Zhang, Y2
Li, S1
Tang, J2
Ma, R1
Yang, X5
Huang, H1
Peng, Y1
Xie, Y4
Peng, Z1
Meng, J1
Hu, G1
Tao, L1
Liu, X1
Yang, H1
Yu, Y3
Zhou, S1
Di, S1
Huang, X1
Chen, Y3
Gayatri Devi, R1
Ezhilarasan, D2
Iacob, RE1
Iacob, D1
Moleriu, RD1
Tit, DM1
Bungau, S1
Otrisal, P1
Aleya, S1
Judea-Pusta, C1
Cioca, G1
Bratu, OG1
Aleya, L1
Petre, I1
Min, RW1
Chen, CQ1
Zhang, J1
Li, M3
Suzuki, A1
Abdelmalek, MF1
Aghajan, M1
Aung, FW1
Diehl, AM1
Davis, RJ1
Maxa, M1
Schaeper, U1
Dames, S1
Vollmar, B1
Kuhla, A1
Groeneveld, D1
Cline-Fedewa, H1
Baker, KS1
Williams, KJ1
Roth, RA3
Mittermeier, K1
Lisman, T2
Palumbo, JS1
Luyendyk, JP2
Hassan, R1
Minsart, C1
Liefferinckx, C1
Lemmers, A1
Dressen, C1
Quertinmont, E1
Leclercq, I1
Devière, J1
Moreau, R1
Gustot, T1
Wan, J1
Kuang, G1
Zhang, L1
Jiang, R1
He, Z1
Ye, D1
Dunn, KW1
Martinez, MM1
Wang, Z3
Mang, HE1
Clendenon, SG2
Sluka, JP2
Glazier, JA2
Klaunig, JE2
Smith, AK2
Ropella, GEP2
McGill, MR11
Krishnan, P1
Dutta, L1
Kennedy, RC3
Hunt, CA2
Britza, SM1
Musgrave, IF1
Byard, RW1
Feldbrügge, L1
Splith, K1
Kämmerer, I1
Richter, S1
Riddermann, A1
Ortiz Galindo, SA1
Krenzien, F1
Müller, T1
Csizmadia, E1
Pratschke, J1
Robson, SC2
Schmelzle, M1
Adhyapok, P1
Fu, X1
Sluka, VD1
Dunn, K1
Raghunandhakumar, S1
Gokkaya, EO1
Yesilot, S1
Ozgocmen, M1
Aslankoc, R1
Aydin Acar, C1
Kresnamurti, A1
Rakhma, DN1
Damayanti, A1
Santoso, SD1
Restryarto, E1
Hadinata, W1
Hamid, IS1
Kim, TH1
Choi, D1
Kim, JY1
Lee, JH1
Koo, SH1
Hopkins, RE1
Dobbin, M1
Pilgrim, JL1
Malsy, M1
Graf, B1
Bundscherer, A1
Papackova, Z1
Heczkova, M1
Dankova, H1
Sticova, E1
Lodererova, A1
Bartonova, L1
Poruba, M1
Cahova, M1
Tezcan, AH1
Ozturk, O1
Ustebay, S1
Adali, Y1
Yagmurdur, H1
Lee, BW1
Jeon, BS1
Yoon, BI1
Wen, Y1
Wang, C2
Gu, J1
Yu, C1
Wang, K1
Sun, X1
Sun, Y1
Wu, H1
Tong, Y2
Xia, Q1
Kong, X1
Wang, L1
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Nadig, DE1
Kokoska, ER1
Solomon, H1
Tiniakos, DG1
Miller, TA1
Michael, SL2
Pumford, NR2
Mayeux, PR1
Niesman, MR1
Bruck, R1
Frenkel, D1
Shirin, H1
Aeed, H1
Matas, Z1
Papa, M1
Zaidel, L1
Avni, Y1
Oren, R1
Halpern, Z1
Kumar, MA1
Hogaboam, CM2
Chensue, SW1
Steinhauser, ML2
Lukacs, NW3
Gauldie, J1
Strieter, RM3
Kunkel, SL3
Czarnecki, R1
Librowski, T1
Polański, M1
Theise, ND1
Saxena, R1
Portmann, BC1
Thung, SN1
Yee, H1
Chiriboga, L1
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Jena, N1
Ault, SG1
McGregor, AH1
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Matsukawa, A1
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Boring, L1
Charo, IF1
Lawson, JA1
Hopper, RD1
Bhanwra, S1
Singh, J1
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Corton, JC1
Patel, D1
Wong, V1
Waters, E1
Wang, JH1
Redmond, HP1
Wu, QD1
Kay, E1
Bouchier-Hayes, D1
Du, J1
Luan, J1
Liu, H1
Daniel, TO1
Peiper, S1
Chen, TS1
Horton, LW1
Nanney, LB1
Richmond, A1
Gujral, JS1
Küçükardali, Y1
Cinan, U1
Acar, HV1
Ozkan, S1
Top, C1
Nalbant, S1
Cermik, H1
Cankir, Z1
Danaci, M1
Lee, SC1
Tsai, CC1
Chen, JC1
Lin, JG1
Lin, CC1
Hu, ML1
Lu, S1
Nagai, H1
Matsumaru, K1
Feng, G1
Goulding, R1
Volans, GN1
Crome, P1
Widdop, B1
Sutherland, GR1
Park, J1
Smith, IJ1
Proudfoot, AT1
Bonkowsky, HL1
Mudge, GH1
McMurtry, RJ3
Chiu, S1
Bhakthan, NM1
Mitchell, JR11
Potter, WZ8
Benedetti, MS2
Louis, A2
Malnoe, A2
Davis, M3
Willson, RA2
Hart, FE1
Skjøtø, J1
Reikvam, A1
Thompson, ML1
Shuster, L1
Shaw, K1
Carloss, H1
Austin, FD1
Ware, AJ1
Upchurch, KS1
Eigenbrodt, EH1
Norman, DA1
Harvey, JG1
Spooner, JB1
Forte, AJ1
Dillman, RO1
Thorgeirsson, SS3
Dybing, E2
Talbot, IC2
Koch-Weser, J1
Lesna, M2
Watson, AJ2
Douglas, AP2
Hamlyn, AN2
Groarke, JF1
Averett, JM1
Hirschowitz, BI1
Emby, DJ1
Fraser, BN1
Krenzelok, EP1
Best, L1
Manoguerra, AS1
McJunkin, B1
Barwick, KW1
Little, WC1
Winfield, JB1
Day, PA1
Rumack, BH1
Matthew, H2
Dixon, MF6
Dixon, B2
Aparicio, SR2
Loney, DP1
Schneider, M1
Smith, RL1
Kreber, L1
Lam, R1
Fulker, MJ1
Walker, BE2
Kelleher, J2
Losowsky, MS2
Portmann, B4
Day, DW1
Davidson, AR1
Murray-Lyon, IM1
Gazzard, BG3
Spooner, J1
Koukoulis, G1
Rayner, A1
Tan, KC1
Edwards, R1
Oliphant, J1
Sakaida, I1
Kayano, K1
Kubota, M1
Mori, K1
Takenaka, K1
Yasunaga, M1
Okita, K1
Madhu, C1
Maziasz, T1
Price, LM1
Poklis, A1
Johnson, DE1
Hughes, RD2
Gove, CD1
Adamson, GM1
Papadimitriou, JM1
Harman, AW1
Helliwell, TR1
Coakley, JH1
Wagenmakers, AJ1
Griffiths, RD1
Campbell, IT1
Green, CJ1
McClelland, P1
Bone, JM1
Shen, W1
Harrison, PM1
Keays, R1
Bray, GP1
Alexander, GJ1
Ishikawa, M1
Tanno, K1
Takayanagi, Y1
Sasaki, K1
Nakae, D1
Yoshiji, H1
Yamamoto, K1
Maruyama, H1
Kinugasa, T1
Takashima, Y1
Denda, A1
Konishi, Y1
Sorge, CL1
Raucy, JL1
Ben-Zvi, Z1
Weissman-Teitellman, B1
Katz, S1
Danon, A1
Kitamura, Y1
Kamisaki, Y1
Itoh, T1
Svendsen, O1
Christensen, HB1
Rygaard, J1
Juul, P1
Cesolari, JA1
Laudanno, OM1
San Miguel, P1
Bedini, OA1
Marzella, L1
Muhvich, K1
Myers, RA1
Foust, RT1
Reddy, KR2
Jeffers, LJ1
Schiff, ER2
Bhatia, A1
Sood, SK1
Baeg, NJ1
Bodenheimer, HC1
Burchard, K1
Haschek, WM1
Kuttner, BJ1
Kurban, RS1
Florén, CH1
Thesleff, P1
Nilsson, A1
Placke, ME2
Ginsberg, GL1
Ludmir, J1
Main, DM1
Landon, MB1
Gabbe, SG1
Aw, TY1
Simon, FR1
Stolz, A1
Powers, BJ1
Cattau, EL1
Bell, H2
Schjønsby, H2
Raknerud, N2
van de Straat, R1
de Vries, J1
Groot, EJ1
Zijl, R1
Vermeulen, NP1
Skoglund, LA1
Ingebrigtsen, K1
Nafstad, I1
Jansen, JH1
Nakagawa, M1
Okabe, S1
Kartsonis, A1
Miller, MG3
Price, VF2
Sørensen, FB1
Landbo, B1
Marcussen, N1
Lesser, PB1
Vietti, MM1
Clark, WD1
Landon, EJ1
Naukam, RJ1
Rama Sastry, BV1
Sato, C1
Izumi, N1
Nouchi, T1
Hasumura, Y1
Takeuchi, J1
Lerche, A1
Pedersen, NT1
Zieve, L2
Anderson, WR1
Dozeman, R2
Draves, K2
Lyftogt, C1
Maldonado, AL1
Tredger, JM1
Smith, HM1
Read, RB1
LaFontaine, D1
Auty, RM1
Branch, RA1
Nimmo, J2
Davis, DC4
Brodie, BB4
Maclean, D1
Peters, TJ1
Brown, RA1
McCathie, M1
Baines, GF1
Robertson, PG1
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Dordoni, B2
Chakrabarti, AK1
Lloyd, GH1
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Wright, N1
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Borirakchanyavat, V1
Chalstrey, LJ2
Parbhoo, SP2
Adjukiewicz, AB1
James, IM1
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Kennedy, J1
Boyer, TD1
Rouff, SL1
Will, EJ1
Tomkins, AM1
Sanerkin, NG1
Pimstone, BL1
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Toghill, PJ1
Stephens, JD1
Carroll, JD1
Davidson, DG1
Eastham, WN1
Boyd, EM1
Bereczky, GM1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Double-blind, Placebo-controlled, Multi-site, Phase III Study to Evaluate the Safety and Efficacy of CD24Fc in COVID-19 Treatment[NCT04317040]Phase 3234 participants (Actual)Interventional2020-04-24Completed
Evaluating the Effects of Acupuncture in the Treatment of Taxane Induces Peripheral Neuropathy (TIPN)[NCT02831114]18 participants (Actual)Interventional2016-05-31Completed
[NCT00799578]Phase 1/Phase 213 participants (Actual)Interventional2008-10-31Completed
A Full-Factorial, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Single-Dose Efficacy and Safety Study of an Acetaminophen/Naproxen Sodium Fixed Combination, Acetaminophen, and Naproxen Sodium in Postoperative Dental Pain[NCT05761574]Phase 3440 participants (Anticipated)Interventional2023-05-22Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Duration of ECMO

Duration of ECMO treatment (days) was calculated as: End Date of ECMO Treatment - Start Date of ECMO Treatment + 1 and reported. (NCT04317040)
Timeframe: Up to Day 29

InterventionDays (Mean)
Placebo11.0

Duration of High Flow Oxygen Therapy

Duration of oxygen therapy (oxygen inhalation by high flow nasal cannula or mask) (days) was calculated as: End Date of high flow oxygen therapy - Start Date of high flow oxygen therapy + 1 and reported. (NCT04317040)
Timeframe: Up to Day 29

InterventionDays (Mean)
CD24Fc13.8
Placebo13.0

Duration of MV

MV included IMV and NIV. Duration of MV (days) was calculated as: End Date of MV - Start Date of MV + 1 and reported. (NCT04317040)
Timeframe: Up to Day 29

InterventionDays (Mean)
CD24Fc14.3
Placebo14.3

Duration of Pressors

Pressor administration included norepinephrine, epinephrine, vasopressin, dopamine and phenylephrine. Duration of pressor (days) was defined as: End Date of Pressor - Start Date of Pressor + 1 and reported. (NCT04317040)
Timeframe: Up to Day 29

InterventionDays (Mean)
CD24Fc6.3
Placebo7.9

Length of Hospital Stay

Length of Hospital Stay (Days) was defined as date of discharge - date of admission + 1 and reported. Data presented below include hospitalization time prior to enrollment in the study with total duration of up to 90 days. (NCT04317040)
Timeframe: Up to 90 days

InterventionDays (Mean)
CD24Fc16.6
Placebo18.2

Number of Participants Who Experience an Adverse Event (AE)

An AE was defined as any unfavorable and unintended sign including an abnormal laboratory finding, symptom or disease associated with the use of a medical treatment or procedure, regardless of whether it is considered related to the medical treatment or procedure, that occurs during the course of the study. Per protocol, only AEs with Common Terminology Criteria for AE (CTACAE) grade ≥3 were included. The number of participants who experienced an AE were reported. (NCT04317040)
Timeframe: Up to 30 days

InterventionParticipants (Count of Participants)
CD24Fc32
Placebo35

Percentage of Participants Who Died or Had Respiratory Failure (RF)

RF was defined as the need for any of the following: 1) mechanical ventilation (MV), 2) ECMO, 3) NIV, or 4) high flow oxygen devices. Percentage of participants who died or had respiratory failure by Day 29 were reported. (NCT04317040)
Timeframe: Up to Day 29

InterventionPercentage of Participants (Number)
CD24Fc22.4
Placebo28.0

Rate of Clinical Relapse

Rate of clinical relapse was defined as the percentage of participants who had initially reached score 5 on NIAID ordinal scale for more than one day but subsequently became dependent on oxygen support for more than 1 day within 28 days from randomization after initial recovery with a total follow-up period of 29 days (Day 1 of randomization plus 28 days of follow-up). NIAID ordinal scale graded as: 1=Death; 2=Hospitalized, on IMV/ECMO; 3=Hospitalized, on NIV/high flow oxygen devices; 4= Hospitalized, require supplemental oxygen; 5=Hospitalized, no supplemental oxygen, require medical care; 6=Hospitalized, no supplemental oxygen, do not require medical care; 7=Not hospitalized, limitation on activities and/or require home oxygen; 8=Not hospitalized, no limitations on activities. Clopper-Pearson method was used to report the 95% CI. (NCT04317040)
Timeframe: Up to Day 29

InterventionPercentage of Participants (Number)
CD24Fc4.3
Placebo6.8

Time to Disease Progression in Clinical Status of COVID-19

Time to disease progression in clinical status is defined as the time (days) for progression from NIAID score (3 or 4) to (2 or 1) or from 2 to 1 within 28 days from randomization, total follow-up period 29 days (Randomization Day 1 + 28 days follow up). NIAID ordinal scale graded as: 1=Death; 2=Hospitalized, on IMV/ECMO; 3=Hospitalized, on NIV/high flow oxygen devices; 4= Hospitalized, require supplemental oxygen; 5=Hospitalized, no supplemental oxygen, require medical care; 6=Hospitalized, no supplemental oxygen, do not require medical care; 7=Not Hospitalized, limitation on activities and/or require home oxygen; 8=Not hospitalized, no limitations on activities. (NCT04317040)
Timeframe: Up to Day 29

InterventionDays (Median)
CD24FcNA
PlaceboNA

Time to Hospital Discharge

The hospital discharge time was defined as the time from randomization to discharge from the hospital and reported. Time to Hospital Discharge (days) from randomization is calculated as: Time to hospital discharge = Date of hospital discharge - Date of randomization. (NCT04317040)
Timeframe: Up to Day 29

InterventionDays (Median)
CD24Fc7.0
Placebo10.5

Time to Improvement in Coronavirus Disease 2019 (COVID-19) Clinical Status

Time to improvement in COVID-19 clinical status: defined as time (days) required from start of treatment to improvement of clinical status severe - moderate/mild or improvement from score 2-4 to ≥5 sustained without drop below 5 within 28 days from randomization, total follow-up period 29 days (Randomization Day 1 + 28 days follow up) per National Institute of Allergy & Infectious Diseases (NIAID) ordinal scale graded: 1=Death; 2=Hospitalized, on invasive mechanical ventilation (IMV)/extracorporeal membrane oxygenation (ECMO); 3=Hospitalized, on non-invasive ventilation (NIV)/high flow oxygen devices; 4=Hospitalized, require supplemental oxygen; 5=Hospitalized, no supplemental oxygen, require medical care; 6=Hospitalized, no supplemental oxygen, don't require medical care; 7=Not hospitalized, limitation on activities &/or require home oxygen; 8=Not hospitalized, no limitations on activities. Median time & 95% confidence intervals (CIs) were reported using Brookmeyer-Crowley method. (NCT04317040)
Timeframe: Up to Day 29

InterventionDays (Median)
CD24Fc6.0
Placebo10.5

Change From Baseline in Absolute Lymphocyte Count

Blood samples were collected to present the change from baseline in the absolute lymphocyte count on days 1, 4, 8, and 15 in peripheral blood. To calculate the change from baseline in absolute lymphocyte count at specific timepoints (Days 1, 4, 8 and 15), only the participants who had both, a baseline, and a post baseline value at the specific timepoint (Days 1, 4, 8 and 15) were included in the analysis. (NCT04317040)
Timeframe: Baseline and up to Day 15

,
Intervention10^9 Cells/Liter (Mean)
BaselineDay 1Day 4Day 8Day 15Change from Baseline to Day 1Change from Baseline to Day 4Change from Baseline to Day 8Change from Baseline to Day 15
CD24Fc2.3575.3172.3732.5571.9650.3740.2190.5750.558
Placebo2.4375.1252.4611.8392.378-0.1480.053-0.491-0.280

Change From Baseline in D-Dimer Concentration

Blood samples were collected to present the change from baseline in the D-dimer concentration on days 4, 8 and 15 in peripheral blood. To calculate change from baseline in D-dimer concentration at specific timepoints (Days 4, 8 and 15), only the participants who had both, a baseline, and a post baseline value at the specific timepoint (Days 4, 8 and 15) were included in the analysis. (NCT04317040)
Timeframe: Baseline and up to Day 15

,
Interventionnmol/Liter (Mean)
BaselineDay 4Day 8Day 15Change from Baseline to Day 4Change from Baseline to Day 8Change from Baseline to Day 15
CD24Fc153.71710.45113.22411.700-0.427-397.5473.076
Placebo9.76713.88513.34913.8923.9710.703-3.591

Conversion Rate of COVID-19 Clinical Status

Conversion rate of COVID-19 clinical status on days 8 and 15 was defined as the percentage of participants who changed from NIAID ordinal score 2, 3, 4 to score 5 or higher and reported. NIAID ordinal scale graded as: 1=Death; 2=Hospitalized, on IMV/ECMO; 3=Hospitalized, on NIV/high flow oxygen devices; 4= Hospitalized, require supplemental oxygen; 5=Hospitalized, no supplemental oxygen, require medical care; 6=Hospitalized, no supplemental oxygen, do not require medical care; 7=Not hospitalized, limitation on activities and/or require home oxygen; 8=Not hospitalized, no limitations on activities. (NCT04317040)
Timeframe: Up to Day 15

,
InterventionPercentage of participants (Number)
Day 8Day 15
CD24Fc55.271.6
Placebo42.455.9

Number of Participants Who Died Due to Any Cause

Number of participants who died due to any cause were assessed per protocol on Day 15 and Day 29. (NCT04317040)
Timeframe: Up to Day 29

,
InterventionParticipants (Count of Participants)
Day 15Day 29
CD24Fc1116
Placebo818

Normalization or >50% of Serum ALT Levels From Baseline

(NCT00799578)
Timeframe: 6 months

Interventionparticipants (Number)
Number of Improved Subjects7

Reviews

27 reviews available for acetaminophen and Necrosis

ArticleYear
Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options.
    Journal of Zhejiang University. Science. B, 2022, Apr-15, Volume: 23, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Chemical a

2022
Platanosides, a Potential Botanical Drug Combination, Decrease Liver Injury Caused by Acetaminophen Overdose in Mice.
    Journal of natural products, 2022, 07-22, Volume: 85, Issue:7

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Combinations; Glycosides; Kelch

2022
Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2020, Volume: 138

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemokines; Cytokines; DNA Fragmenta

2020
Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver.
    Redox biology, 2013, Aug-26, Volume: 1

    Topics: Acetaminophen; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Humans; Mitochondria; Nec

2013
Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study.
    Chinese journal of cancer, 2014, Volume: 33, Issue:7

    Topics: Acetaminophen; Adult; Carcinoma, Hepatocellular; Disease Progression; Drug Therapy, Combination; Enz

2014
Mechanisms of acetaminophen-induced liver necrosis.
    Handbook of experimental pharmacology, 2010, Issue:196

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biotransformation; Chemical and Drug Induced Liver

2010
Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products.
    Life sciences, 2011, Apr-25, Volume: 88, Issue:17-18

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Biological Products; Cell Death; Diseas

2011
Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity.
    Liver international : official journal of the International Association for the Study of the Liver, 2012, Volume: 32, Issue:1

    Topics: Acetaminophen; Animals; Autoimmunity; Chemical and Drug Induced Liver Injury; Hepatocytes; Humans; I

2012
Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity.
    Drug metabolism reviews, 2012, Volume: 44, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antioxidants; Apoptosis; Cell Death; Chemical and Drug Indu

2012
The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity.
    Toxicology letters, 2003, Oct-15, Volume: 144, Issue:3

    Topics: Acetaminophen; Adenosine Triphosphate; Analgesics, Non-Narcotic; Animals; Apoptosis; Humans; Lipid P

2003
Intracellular signaling mechanisms of acetaminophen-induced liver cell death.
    Toxicological sciences : an official journal of the Society of Toxicology, 2006, Volume: 89, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Apoptosis; Cell Death; DNA Fragmentation; Hepatocytes; Live

2006
Apoptosis and necrosis in the liver: a tale of two deaths?
    Hepatology (Baltimore, Md.), 2006, Volume: 43, Issue:2 Suppl 1

    Topics: Acetaminophen; Animals; Apoptosis; Apoptosis Regulatory Proteins; Caspases; Cholestasis, Intrahepati

2006
The treatment of acetaminophen poisoning.
    Annual review of pharmacology and toxicology, 1983, Volume: 23

    Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Antidotes; Aspartate Aminotransferases; Biotran

1983
Drug induced liver disease.
    Postgraduate medical journal, 1983, Volume: 59 Suppl 4

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Necrosis

1983
Acetaminophen hepatotoxicity.
    Annual review of medicine, 1984, Volume: 35

    Topics: Acetaminophen; Adult; Aged; Alcoholism; Chemical and Drug Induced Liver Injury; Chemical Phenomena;

1984
Mechanisms of cell injury with hepatotoxic chemicals.
    Pharmacological reviews, 1984, Volume: 36, Issue:2 Suppl

    Topics: Acetaminophen; Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Che

1984
[Paracetamol: overdose and hepatic lesions].
    La Clinica terapeutica, 1981, Jul-31, Volume: 98, Issue:2

    Topics: Acetaminophen; Aspirin; Chemical and Drug Induced Liver Injury; Fever; Humans; Liver; Necrosis; Pain

1981
Acetaminophen/aspirin mixtures: experimental data.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1996, Volume: 28, Issue:1 Suppl 1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin;

1996
Drug metabolism in the production of liver injury.
    The Medical clinics of North America, 1975, Volume: 59, Issue:4

    Topics: Acetaminophen; Acetanilides; Alkylating Agents; Bromobenzenes; Chemical and Drug Induced Liver Injur

1975
The third Lilly Prize Lecture. University of London, January, 1979. The nephrotoxicity and hepatotoxicity of antipyretic analgesics.
    British journal of clinical pharmacology, 1979, Volume: 7, Issue:5

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induced Liver Inj

1979
Metabolic activation: biochemical basis for many drug-induced liver injuries.
    Progress in liver diseases, 1976, Volume: 5

    Topics: Acetaminophen; Animals; Binding Sites; Carcinogens; Chemical and Drug Induced Liver Injury; Drug Hyp

1976
Acute liver injury.
    Journal of clinical pathology. Supplement (Royal College of Pathologists), 1975, Volume: 9

    Topics: Acetaminophen; Acute Disease; Chemical and Drug Induced Liver Injury; Cholestasis; Halothane; Hepati

1975
Drug-induced hepatotoxicity.
    Annals of internal medicine, 1986, Volume: 104, Issue:6

    Topics: Acetaminophen; Bile; Bile Acids and Salts; Biotransformation; Cell Survival; Chemical and Drug Induc

1986
Chlorzoxazone hepatotoxic reactions. An analysis of 21 identified or presumed cases.
    Archives of internal medicine, 1986, Volume: 146, Issue:6

    Topics: Acetaminophen; Adult; Aged; Benzoxazoles; Biopsy; Chlorzoxazone; Drug Combinations; Drug Evaluation;

1986
Protective agents for acetaminophen overdose.
    Seminars in liver disease, 1986, Volume: 6, Issue:2

    Topics: Acetaminophen; Acetylcysteine; Animals; Cell Membrane; Chemical and Drug Induced Liver Injury; Cimet

1986
The biochemical pathology of toxic cell death.
    Monographs in pathology, 1985, Issue:26

    Topics: Acetaminophen; Animals; Biotransformation; Calcium; Carbon Tetrachloride; Cell Membrane; Cell Membra

1985
Acute hepatic necrosis and fulminant hepatic failure.
    Gut, 1973, Volume: 14, Issue:10

    Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Animals; Blood Coagulation Disorders; Brain Dise

1973

Trials

3 trials available for acetaminophen and Necrosis

ArticleYear
Drug therapy. Acetaminophen.
    The New England journal of medicine, 1976, Dec-02, Volume: 295, Issue:23

    Topics: Acetaminophen; Adolescent; Adult; Aspirin; Body Temperature; Chemical and Drug Induced Liver Injury;

1976
Reduction of absorption of paracetamol by activated charcoal and cholestyramine: a possible therapeutic measure.
    British medical journal, 1973, Jul-14, Volume: 3, Issue:5871

    Topics: Acetaminophen; Administration, Oral; Charcoal; Chemical and Drug Induced Liver Injury; Cholestyramin

1973
A controlled trial of heparin therapy in the coagulation defect of paracetamol-induced hepatic necrosis.
    Gut, 1974, Volume: 15, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Blood Coagulation Disorders; Blood Transfusion; Chemical and Drug

1974

Other Studies

393 other studies available for acetaminophen and Necrosis

ArticleYear
Inhibition of Drug-Induced Liver Injury in Mice Using a Positively Charged Peptide That Binds DNA.
    Hepatology communications, 2021, Volume: 5, Issue:10

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Chemokine

2021
CoQ10 Promotes Resolution of Necrosis and Liver Regeneration After Acetaminophen-Induced Liver Injury.
    Toxicological sciences : an official journal of the Society of Toxicology, 2021, 12-28, Volume: 185, Issue:1

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju

2021
Noninvasive Assessment of APAP (N-acetyl-p-aminophenol)-Induced Hepatotoxicity Using Multiple MRI Parameters in an Experimental Rat Model.
    Journal of magnetic resonance imaging : JMRI, 2022, Volume: 56, Issue:6

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Contrast Media; Diffusion Magnetic R

2022
Recovered Hepatocytes Promote Macrophage Apoptosis Through CXCR4 After Acetaminophen-Induced Liver Injury in Mice.
    Toxicological sciences : an official journal of the Society of Toxicology, 2022, 07-28, Volume: 188, Issue:2

    Topics: Acetaminophen; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced

2022
The danger signal interferon-induced protein 35 (IFP35) mediates acetaminophen-induced liver injury.
    Biochemical and biophysical research communications, 2022, 09-17, Volume: 621

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Interferons; Intracellular Signaling

2022
Susceptibility to Infections During Acute Liver Injury Depends on Transient Disruption of Liver Macrophage Niche.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Acetaminophen; Humans; Kupffer Cells; Liver; Macrophages; Monocytes; Necrosis

2022
Hepatoprotective effect of nicorandil against acetaminophen-induced oxidative stress and hepatotoxicity in mice via modulating NO synthesis.
    Environmental science and pollution research international, 2023, Volume: 30, Issue:6

    Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Liver; Mice; Necrosis;

2023
Desorption Electrospray Ionization Mass Spectrometry Imaging Allows Spatial Localization of Changes in Acetaminophen Metabolism in the Liver after Intervention with 4-Methylpyrazole.
    Journal of the American Society for Mass Spectrometry, 2022, Nov-02, Volume: 33, Issue:11

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Fomepizole; Humans; Liver; Mice; Mic

2022
c-
    Antioxidants & redox signaling, 2023, Volume: 38, Issue:16-18

    Topics: Acetaminophen; Animals; Catalytic Domain; Chemical and Drug Induced Liver Injury; Glutamate-Cysteine

2023
Rosiglitazone Protects against Acetaminophen-Induced Acute Liver Injury by Inhibiting Multiple Endoplasmic Reticulum Stress Pathways.
    BioMed research international, 2022, Volume: 2022

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Chaperone BiP;

2022
Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver.
    Journal of gastroenterology and hepatology, 2023, Volume: 38, Issue:4

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Homeodomain Proteins; Inflammation;

2023
Dose-dependent pleiotropic role of neutrophils during acetaminophen-induced liver injury in male and female mice.
    Archives of toxicology, 2023, Volume: 97, Issue:5

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inju

2023
Essential Involvement of Neutrophil Elastase in Acute Acetaminophen Hepatotoxicity Using BALB/c Mice.
    International journal of molecular sciences, 2023, Apr-25, Volume: 24, Issue:9

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Leukocyte Elastase; Liver Diseases;

2023
Fluorofenidone protects against acute liver failure in mice by regulating MKK4/JNK pathway.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 164

    Topics: Acetaminophen; Animals; Anisomycin; Hepatocytes; Lipopolysaccharides; Liver; Liver Failure, Acute; M

2023
Leonurine alleviates acetaminophen-induced acute liver injury by regulating the PI3K/AKT signaling pathway in mice.
    International immunopharmacology, 2023, Volume: 120

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Inflammation; Liver; Mice; Molecular

2023
Concurrent administration of farnesol protects acetaminophen-induced acute hepatic necrosis in mice.
    Journal of biochemical and molecular toxicology, 2023, Volume: 37, Issue:11

    Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Chemical and Drug Induce

2023
Consequences of analgesics use in early pregnancy: Results of tests on mice.
    The Science of the total environment, 2019, Nov-15, Volume: 691

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Female; Ki

2019
Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury.
    The Journal of clinical investigation, 2019, 12-02, Volume: 129, Issue:12

    Topics: Acetaminophen; Animals; Apoptosis; Cell Death; Chemical and Drug Induced Liver Injury; Estrogen Rece

2019
Liver-specific Bid silencing inhibits APAP-induced cell death in mice.
    Apoptosis : an international journal on programmed cell death, 2019, Volume: 24, Issue:11-12

    Topics: Acetaminophen; Animals; Apoptosis; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist

2019
Von Willebrand factor delays liver repair after acetaminophen-induced acute liver injury in mice.
    Journal of hepatology, 2020, Volume: 72, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Blood Coagulation; Blood Platelets; Chemical and D

2020
Acetaminophen induces programmed necrosis.
    Archives of toxicology, 2019, Volume: 93, Issue:12

    Topics: Acetaminophen; Apoptosis; Cell Death; Chemical and Drug Induced Liver Injury, Chronic; Humans; Liver

2019
New insights in acetaminophen toxicity: HMGB1 contributes by itself to amplify hepatocyte necrosis in vitro through the TLR4-TRIF-RIPK3 axis.
    Scientific reports, 2020, 03-27, Volume: 10, Issue:1

    Topics: Acetaminophen; Adaptor Proteins, Vesicular Transport; Cell Line; Cell Line, Tumor; Cells, Cultured;

2020
Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via upregulation of heme oxygenase-1 expression.
    International immunopharmacology, 2020, Volume: 83

    Topics: Acetaminophen; Animals; Apoptosis; Cell Death; Cell Line; Chemical and Drug Induced Liver Injury; Do

2020
Mitochondrial depolarization and repolarization in the early stages of acetaminophen hepatotoxicity in mice.
    Toxicology, 2020, Volume: 439

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases;

2020
Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms.
    PLoS computational biology, 2020, Volume: 16, Issue:6

    Topics: Acetaminophen; Alanine Transaminase; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Co

2020
Paracetamol (acetaminophen) hepatotoxicity increases in the presence of an added herbal compound.
    Legal medicine (Tokyo, Japan), 2020, Volume: 47

    Topics: Acetaminophen; Cell Death; Chemical and Drug Induced Liver Injury; Drug Synergism; Ficusin; Hep G2 C

2020
Ecto-Nucleotide Triphosphate Diphosphohydrolase-2 (NTPDase2) Deletion Increases Acetaminophen-Induced Hepatotoxicity.
    International journal of molecular sciences, 2020, Aug-20, Volume: 21, Issue:17

    Topics: Acetaminophen; Adenosine Triphosphatases; Alanine Transaminase; Alkaline Phosphatase; Animals; Chemi

2020
A computational model of liver tissue damage and repair.
    PloS one, 2020, Volume: 15, Issue:12

    Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Cell Prolifera

2020
Boldine treatment protects acetaminophen-induced liver inflammation and acute hepatic necrosis in mice.
    Journal of biochemical and molecular toxicology, 2021, Volume: 35, Issue:4

    Topics: Acetaminophen; Acetylcysteine; Animals; Aporphines; Chemical and Drug Induced Liver Injury; Cytokine

2021
Protective effects of resveratrol and avocado oil against paracetamol-induced hepatotoxicity in rats.
    Drug and chemical toxicology, 2022, Volume: 45, Issue:5

    Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Liver; Necrosis; Oxida

2022
AST/ALT levels, MDA, and liver histopathology of 
    Journal of basic and clinical physiology and pharmacology, 2021, Jun-25, Volume: 32, Issue:4

    Topics: Acetaminophen; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Liver; Liver Diseases;

2021
Fast food diet-induced non-alcoholic fatty liver disease exerts early protective effect against acetaminophen intoxication in mice.
    BMC gastroenterology, 2017, Nov-28, Volume: 17, Issue:1

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li

2017
Unintentional mortality associated with paracetamol and codeine preparations, with and without doxylamine, in Australia.
    Forensic science international, 2018, Volume: 282

    Topics: Accidents; Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Antiemetics; Austr

2018
Effects of metamizole, MAA, and paracetamol on proliferation, apoptosis, and necrosis in the pancreatic cancer cell lines PaTu 8988 t and Panc-1.
    BMC pharmacology & toxicology, 2017, 12-06, Volume: 18, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Age

2017
Silymarin prevents acetaminophen-induced hepatotoxicity in mice.
    PloS one, 2018, Volume: 13, Issue:1

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Liver; Male; Mice; Mi

2018
The beneficial effects of ozone therapy in acetaminophen-induced hepatotoxicity in mice.
    Pharmacological reports : PR, 2018, Volume: 70, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical an

2018
Exogenous recombinant human thioredoxin-1 prevents acetaminophen-induced liver injury by scavenging oxidative stressors, restoring the thioredoxin-1 system and inhibiting receptor interacting protein-3 overexpression.
    Journal of applied toxicology : JAT, 2018, Volume: 38, Issue:7

    Topics: Acetaminophen; Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Cytoprotect

2018
Metabolic modulation of acetaminophen-induced hepatotoxicity by osteopontin.
    Cellular & molecular immunology, 2019, Volume: 16, Issue:5

    Topics: Acetaminophen; Animals; Apoptosis; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytochro

2019
Inhibition of acetaminophen-induced hepatotoxicity in mice by exogenous thymosinβ4 treatment.
    International immunopharmacology, 2018, Volume: 61

    Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Autophagy;

2018
Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury: possible involvement of ER stress and S6K1 activation.
    BMB reports, 2019, Volume: 52, Issue:3

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Stress; Hepato

2019
Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity.
    Archives of toxicology, 2019, Volume: 93, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Animals; Antioxidants; Apoptosis; Caspase 3; Chemical and Drug Induce

2019
Integrative proteomics and immunochemistry analysis of the factors in the necrosis and repair in acetaminophen-induced acute liver injury in mice.
    Journal of cellular physiology, 2019, Volume: 234, Issue:5

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Hepatocytes; Immunochemistry; Liver;

2019
Improved protective effects of American ginseng berry against acetaminophen-induced liver toxicity through TNF-α-mediated caspase-3/-8/-9 signaling pathways.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2018, Dec-01, Volume: 51

    Topics: Acetaminophen; Alanine Transaminase; Aldehydes; Animals; Aspartate Aminotransferases; Caspases; Chem

2018
Prevention of acetaminophen-induced liver injury by alginate.
    Toxicology and applied pharmacology, 2019, 01-15, Volume: 363

    Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Alginates; Analgesics, Non-Narcotic; Anim

2019
The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2019, Volume: 125

    Topics: Acetaminophen; Animals; beta Catenin; Cell Proliferation; Chemical and Drug Induced Liver Injury; En

2019
Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange.
    Toxicological sciences : an official journal of the Society of Toxicology, 2019, 05-01, Volume: 169, Issue:1

    Topics: Acetaminophen; Activation, Metabolic; Analgesics, Non-Narcotic; Animals; Cell Communication; Chemica

2019
The TGFβ1 Receptor Antagonist GW788388 Reduces JNK Activation and Protects Against Acetaminophen Hepatotoxicity in Mice.
    Toxicological sciences : an official journal of the Society of Toxicology, 2019, 05-01, Volume: 170, Issue:2

    Topics: Acetaminophen; Animals; Antioxidants; Apoptosis; Benzamides; Cell Death; Chemical and Drug Induced L

2019
Acetaminophen-induced liver injury is mediated by the ion channel TRPV4.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:9

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cells, Cultured; Chemical and Drug Induced Liver I

2019
Cell-free DNA in blood circulation is generated by DNase1L3 and caspase-activated DNase.
    Biochemical and biophysical research communications, 2019, 08-27, Volume: 516, Issue:3

    Topics: Acetaminophen; Animals; Antibodies, Neutralizing; Cell-Free Nucleic Acids; Deoxyribonucleases; Endod

2019
Tissue Necrosis and Fungal Rhinosinusitis Resulting From Intranasal Acetaminophen Use.
    Ear, nose, & throat journal, 2020, Volume: 99, Issue:10

    Topics: Acetaminophen; Administration, Intranasal; Adult; Female; Humans; Medical Illustration; Mycoses; Nas

2020
Dichotomous Role of Plasmin in Regulation of Macrophage Function after Acetaminophen Overdose.
    The American journal of pathology, 2019, Volume: 189, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Drug Overd

2019
TAFI deficiency promotes liver damage in murine models of liver failure through defective down-regulation of hepatic inflammation.
    Thrombosis and haemostasis, 2013, Volume: 109, Issue:5

    Topics: Acetaminophen; Actins; Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Ca

2013
The ameliorative effects of L-2-oxothiazolidine-4-carboxylate on acetaminophen-induced hepatotoxicity in mice.
    Molecules (Basel, Switzerland), 2013, Mar-18, Volume: 18, Issue:3

    Topics: Acetaminophen; Alanine Transaminase; Aldehydes; Analgesics, Non-Narcotic; Animals; Antioxidants; Apo

2013
Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice.
    Hepatology (Baltimore, Md.), 2013, Volume: 58, Issue:6

    Topics: Acetaminophen; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepa

2013
Korean red ginseng extract prevents APAP-induced hepatotoxicity through metabolic enzyme regulation: the role of ginsenoside Rg3, a protopanaxadiol.
    Liver international : official journal of the International Association for the Study of the Liver, 2013, Volume: 33, Issue:7

    Topics: Acetaminophen; Animals; Gene Expression Regulation, Enzymologic; Ginsenosides; Lethal Dose 50; Liver

2013
Protein kinase C (PKC) participates in acetaminophen hepatotoxicity through c-jun-N-terminal kinase (JNK)-dependent and -independent signaling pathways.
    Hepatology (Baltimore, Md.), 2014, Volume: 59, Issue:4

    Topics: Acetaminophen; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Chemical and Drug Induced Li

2014
Early detection of paracetamol toxicity using circulating liver microRNA and markers of cell necrosis.
    British journal of clinical pharmacology, 2014, Volume: 77, Issue:5

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Humans; Liver; Male; MicroRNAs; Necrosis

2014
Hepatoprotective, antioxidant, and ameliorative effects of ginger (Zingiber officinale Roscoe) and vitamin E in acetaminophen treated rats.
    Journal of dietary supplements, 2013, Volume: 10, Issue:3

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants; Aspartate Amin

2013
Anorectal necrosis after paracetamol abuse.
    The British journal of dermatology, 2014, Volume: 170, Issue:1

    Topics: Acetaminophen; Adult; Anal Canal; Analgesics, Non-Narcotic; Back Pain; Female; Humans; Necrosis; Rec

2014
Curcumin protects against acetaminophen-induced apoptosis in hepatic injury.
    World journal of gastroenterology, 2013, Nov-14, Volume: 19, Issue:42

    Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; B

2013
Role of connexin 32 in acetaminophen toxicity in a knockout mice model.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2014, Volume: 66, Issue:2-3

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Connexins; Dose-Response Relationshi

2014
Role of receptor interacting protein (RIP)1 on apoptosis-inducing factor-mediated necroptosis during acetaminophen-evoked acute liver failure in mice.
    Toxicology letters, 2014, Mar-21, Volume: 225, Issue:3

    Topics: Acetaminophen; Animals; Apoptosis Inducing Factor; Chemical and Drug Induced Liver Injury; Cytochrom

2014
HMGB1 neutralization is associated with bacterial translocation during acetaminophen hepatotoxicity.
    BMC gastroenterology, 2014, Apr-05, Volume: 14

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Bacterial Translocation; Chemical and Drug Induced

2014
Therapeutic potential of different commercially available synbiotic on acetaminophen-induced uremic rats.
    Clinical and experimental nephrology, 2015, Volume: 19, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Urea Nitrogen; Cata

2015
[Anorectal necrosis and paracetamol suppository abuse].
    Annales de dermatologie et de venereologie, 2014, Volume: 141, Issue:5

    Topics: Acetaminophen; Adult; Anal Canal; Anti-Inflammatory Agents, Non-Steroidal; Drug Overdose; Female; Hu

2014
Mechanisms of acetaminophen-induced cell death in primary human hepatocytes.
    Toxicology and applied pharmacology, 2014, Sep-15, Volume: 279, Issue:3

    Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Analgesics, Non-Narcotic; Antidotes; Cell Death; Enzyme

2014
Carbamoyl phosphate synthetase-1 is a rapid turnover biomarker in mouse and human acute liver injury.
    American journal of physiology. Gastrointestinal and liver physiology, 2014, Aug-01, Volume: 307, Issue:3

    Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; Biomarkers; Carbamoyl-Phosphate Synthase (A

2014
Targeting mitochondria with methylene blue protects mice against acetaminophen-induced liver injury.
    Hepatology (Baltimore, Md.), 2015, Volume: 61, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Cell Death; Cells, Cultured; Chemic

2015
Protective effect of artichoke leaf extract against paracetamol-induced hepatotoxicity in rats.
    Pharmaceutical biology, 2015, Volume: 53, Issue:2

    Topics: Acetaminophen; Animals; Antioxidants; Apoptosis; Biomarkers; Chemical and Drug Induced Liver Injury;

2015
Immunohistochemical and molecular study on the protective effect of curcumin against hepatic toxicity induced by paracetamol in Wistar rats.
    BMC complementary and alternative medicine, 2014, Nov-29, Volume: 14

    Topics: Acetaminophen; Acute-Phase Proteins; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and D

2014
Pleurotus ostreatus opposes mitochondrial dysfunction and oxidative stress in acetaminophen-induced hepato-renal injury.
    BMC complementary and alternative medicine, 2014, Dec-15, Volume: 14

    Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Biological

2014
The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis.
    The Journal of clinical investigation, 2015, Volume: 125, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; fas Recept

2015
Education and imaging. Hepatology: Rare Stevens-Johnson syndrome and vanishing bile duct syndrome induced by acetaminophen, requiring liver transplantation.
    Journal of gastroenterology and hepatology, 2015, Volume: 30, Issue:4

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Bile Ducts, Intrahepatic; Cholestasis; Dilat

2015
Early activated hepatic stellate cell-derived molecules reverse acute hepatic injury.
    World journal of gastroenterology, 2015, Apr-14, Volume: 21, Issue:14

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Cell Shape; Cells, Cultured; Chemical and Drug Ind

2015
Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice.
    World journal of gastroenterology, 2015, Apr-14, Volume: 21, Issue:14

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Chemical and Drug Induce

2015
Protective effects of ethanolic extract of Nigella sativa seed in paracetamol induced acute hepatotoxicity in vivo.
    Pakistan journal of biological sciences : PJBS, 2014, Volume: 17, Issue:4

    Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Apoptosis; Asparta

2014
Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury.
    Cell death & disease, 2015, May-07, Volume: 6

    Topics: Acetaminophen; Animals; Apoptosis; Carrier Proteins; Caspase 8; Chemokine CCL2; Concanavalin A; Dise

2015
Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis.
    Hepatology (Baltimore, Md.), 2015, Volume: 62, Issue:6

    Topics: Acetaminophen; Animals; Apoptosis; Male; Mice; Mice, Inbred C57BL; Necrosis; Organelles; Protein Kin

2015
Subcutaneous Injection of Percocet: A Case of Severe Soft Tissue Loss.
    Wounds : a compendium of clinical research and practice, 2015, Volume: 27, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Cellulitis; Debridement; Drug Combinations; Drug Eruptions;

2015
Withaferin-A Reduces Acetaminophen-Induced Liver Injury in Mice.
    Biochemical pharmacology, 2015, Sep-01, Volume: 97, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Cell Line; Cell Survival; Chemical a

2015
Loss of 5-lipoxygenase activity protects mice against paracetamol-induced liver toxicity.
    British journal of pharmacology, 2016, Volume: 173, Issue:1

    Topics: Acetaminophen; Alanine Transaminase; Angiogenic Proteins; Animals; Aspartate Aminotransferases; Chem

2016
The end of RIPK1-RIPK3-MLKL-mediated necroptosis in acetaminophen-induced hepatotoxicity?
    Hepatology (Baltimore, Md.), 2016, Volume: 64, Issue:1

    Topics: Acetaminophen; Apoptosis; Chemical and Drug Induced Liver Injury; Humans; Necrosis; Receptor-Interac

2016
Enhanced Production of Adenosine Triphosphate by Pharmacological Activation of Adenosine Monophosphate-Activated Protein Kinase Ameliorates Acetaminophen-Induced Liver Injury.
    Molecules and cells, 2015, Volume: 38, Issue:10

    Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; AMP-Activated Protein Kinases; Animals;

2015
Comparative metabonomic analysis of hepatotoxicity induced by acetaminophen and its less toxic meta-isomer.
    Archives of toxicology, 2016, Volume: 90, Issue:12

    Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Biomarkers; Biotransformation; Che

2016
Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices.
    Chemical research in toxicology, 2016, Mar-21, Volume: 29, Issue:3

    Topics: Acetaminophen; Aged; Benzofurans; Bile Acids and Salts; Chloramphenicol; Chlorpromazine; Cholestasis

2016
Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury?
    Toxicological sciences : an official journal of the Society of Toxicology, 2016, Volume: 151, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Aged; Animals; Chemical and Drug Induced Liver Injury; Child, Pres

2016
Reducing Hepatocyte Injury and Necrosis in Response to Paracetamol Using Noncoding RNAs.
    Stem cells translational medicine, 2016, Volume: 5, Issue:6

    Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Female; Hepatocytes; Humans; Liver; Ma

2016
Quercitrin from Toona sinensis (Juss.) M.Roem. Attenuates Acetaminophen-Induced Acute Liver Toxicity in HepG2 Cells and Mice through Induction of Antioxidant Machinery and Inhibition of Inflammation.
    Nutrients, 2016, Jul-15, Volume: 8, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxida

2016
Plasma biomarkers to study mechanisms of liver injury in patients with hypoxic hepatitis.
    Liver international : official journal of the International Association for the Study of the Liver, 2017, Volume: 37, Issue:3

    Topics: Acetaminophen; Adolescent; Adult; Alanine Transaminase; Apoptosis; Biomarkers; DNA Fragmentation; DN

2017
Serum microRNAs-217 and -375 as biomarkers of acute pancreatic injury in rats.
    Toxicology, 2016, Aug-10, Volume: 368-369

    Topics: Acetaminophen; Acinar Cells; Acute Disease; Amylases; Animals; Biomarkers; Ceruletide; Disease Model

2016
Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction.
    Toxicological sciences : an official journal of the Society of Toxicology, 2016, Volume: 154, Issue:2

    Topics: Acetaminophen; Animals; Antioxidants; Cell Line; Chemical and Drug Induced Liver Injury; Cytoprotect

2016
Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress.
    Journal of gastroenterology, 2017, Volume: 52, Issue:5

    Topics: Acetaminophen; Animals; Apoptosis; bcl-2-Associated X Protein; Chemical and Drug Induced Liver Injur

2017
Autotransplantation of Spleen Mitigates Drug-Induced Liver Damage in Splenectomized Mice.
    Journal of investigative surgery : the official journal of the Academy of Surgical Research, 2017, Volume: 30, Issue:6

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Erythrocyte

2017
Dehydrogenase interference with enzymatic ethanol assays: forgotten but not gone.
    Clinical chemistry, 2008, Volume: 54, Issue:7

    Topics: Acetaminophen; Ethanol; False Positive Reactions; Humans; L-Lactate Dehydrogenase; Lactic Acid; Live

2008
Effects of erdosteine on acetaminophen-induced hepatotoxicity in rats.
    Toxicologic pathology, 2008, Volume: 36, Issue:5

    Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Catalase; D

2008
The effects of royal jelly on liver damage induced by paracetamol in mice.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2009, Volume: 61, Issue:2

    Topics: Acetaminophen; Amino Acids; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injur

2009
Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury.
    Journal of leukocyte biology, 2008, Volume: 84, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Bone Marrow; Female; Flow Cytometry; Hu

2008
Protection of acetaminophen induced mitochondrial dysfunctions and hepatic necrosis via Akt-NF-kappaB pathway: role of a novel plant protein.
    Chemico-biological interactions, 2009, Jan-27, Volume: 177, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Apoptosis; Cajanus; Cell Survival; C

2009
CD24 and Siglec-10 selectively repress tissue damage-induced immune responses.
    Science (New York, N.Y.), 2009, Mar-27, Volume: 323, Issue:5922

    Topics: Acetaminophen; Animals; CD24 Antigen; Cytokines; Dendritic Cells; HMGB1 Protein; HSP70 Heat-Shock Pr

2009
Post-endoscopic retrograde cholangiopancreatography uvular necrosis.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2009, Volume: 7, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Cholangiopancreatography, Endoscopic Retrograde; Humans; Ma

2009
Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen.
    Toxicologic pathology, 2009, Volume: 37, Issue:2

    Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartat

2009
CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes.
    Toxicology and applied pharmacology, 2009, Apr-01, Volume: 236, Issue:1

    Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Chemical and Drug Induced Liver Injury;

2009
Phyllanthus urinaria extract attenuates acetaminophen induced hepatotoxicity: involvement of cytochrome P450 CYP2E1.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2009, Volume: 16, Issue:8

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1 Inhibitors;

2009
Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity.
    Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:8

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Aspar

2009
[Acute renal failure after acetaminophen poisoning: report of three cases].
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2009, Volume: 56, Issue:10

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Analgesics, Non-Narcotic; Anuria; Creatinine;

2009
High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo.
    Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 112, Issue:2

    Topics: Acetaminophen; Acetylation; Amino Acid Sequence; Animals; Apoptosis; Blotting, Western; Caspase Inhi

2009
Protective Effects of the Supernatant of Ethanol Eluate from Artemisia sacrorum Ledeb. against Acetaminophen-Induced Liver Injury in Mice [corrected].
    Biological & pharmaceutical bulletin, 2009, Volume: 32, Issue:10

    Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; Artemisia; Aspartate Aminotransferases; Cas

2009
Acanthoic acid, a diterpene in Acanthopanax koreanum, protects acetaminophen-induced hepatic toxicity in mice.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2010, Volume: 17, Issue:6

    Topics: Acetaminophen; Animals; Antioxidants; Caspase 3; Chemical and Drug Induced Liver Injury; Diterpenes;

2010
Acute exposure to ozone exacerbates acetaminophen-induced liver injury in mice.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 115, Issue:1

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Bromodeoxyuridine; Bronchoal

2010
Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury.
    Hepatology (Baltimore, Md.), 2010, Volume: 51, Issue:6

    Topics: Acetaminophen; Alanine Transaminase; Albumins; Analgesics, Non-Narcotic; Anesthetics, Local; Animals

2010
Human recombinant vascular endothelial growth factor reduces necrosis and enhances hepatocyte regeneration in a mouse model of acetaminophen toxicity.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 334, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytokines;

2010
Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice.
    Liver international : official journal of the International Association for the Study of the Liver, 2010, Volume: 30, Issue:9

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; CD18 Antigens; Chemical and Drug Induc

2010
Increased mitochondrial stress and modulation of mitochondrial respiratory enzyme activities in acetaminophen-induced toxicity in mouse macrophage cells.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2010, Volume: 48, Issue:10

    Topics: Acetaminophen; Adenosine Triphosphate; Analgesics, Non-Narcotic; Animals; Apoptosis; Caspase 3; Cell

2010
rhIL-1Ra reduces hepatocellular apoptosis in mice with acetaminophen-induced acute liver failure.
    Laboratory investigation; a journal of technical methods and pathology, 2010, Volume: 90, Issue:12

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Apoptosis; Aspartate Aminotr

2010
Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2010, Volume: 48, Issue:11

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Inju

2010
Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury.
    Free radical research, 2011, Volume: 45, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cyclophilins;

2011
Histopathology and biochemistry analysis of the interaction between sunitinib and paracetamol in mice.
    BMC pharmacology, 2010, Oct-15, Volume: 10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antineoplastic Agents; Antipyretics; Biomarkers; B

2010
The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity.
    Toxicology and applied pharmacology, 2011, Mar-15, Volume: 251, Issue:3

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li

2011
HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity.
    Hepatology (Baltimore, Md.), 2011, Volume: 53, Issue:3

    Topics: Acetaminophen; Animals; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Cysteine; Female;

2011
Necrosis versus apoptosis in acetaminophen-induced hepatotoxicity.
    Hepatology (Baltimore, Md.), 2011, Volume: 53, Issue:3

    Topics: Acetaminophen; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Liver Failure, Acute; Mic

2011
Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity.
    Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 122, Issue:2

    Topics: Acetaminophen; Animals; Apoptosis Inducing Factor; Blotting, Western; Chemical and Drug Induced Live

2011
Susceptibility of rat non-alcoholic fatty liver to the acute toxic effect of acetaminophen.
    Journal of gastroenterology and hepatology, 2012, Volume: 27, Issue:2

    Topics: Acetaminophen; Animals; Biomarkers; Caspase 3; Chemical and Drug Induced Liver Injury; Cholesterol;

2012
Evaluation of phytoconstituents and anti-nephrotoxic and antioxidant activities of Monochoria vaginalis.
    Pakistan journal of pharmaceutical sciences, 2011, Volume: 24, Issue:3

    Topics: Acetaminophen; Animals; Antioxidants; Creatine; Disease Models, Animal; Ethanol; Kidney Diseases; Ma

2011
Circulating apoptotic and necrotic cell death markers in patients with acute liver injury.
    Liver international : official journal of the International Association for the Study of the Liver, 2011, Volume: 31, Issue:8

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analysis of Variance; Apoptosis; Biomarkers; C

2011
Apical membrane rupture and backward bile flooding in acetaminophen-induced hepatocyte necrosis.
    Cell death & disease, 2011, Jul-21, Volume: 2

    Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Bile Canaliculi; Cell M

2011
Elevated serum neopterin levels in acetaminophen-induced liver injury.
    Environmental toxicology and pharmacology, 2011, Volume: 31, Issue:1

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases;

2011
Interaction of α-melanocortin and its pentapeptide antisense LVKAT: effects on hepatoprotection in male CBA mice.
    Molecules (Basel, Switzerland), 2011, Aug-26, Volume: 16, Issue:9

    Topics: Acetaminophen; Alanine Transaminase; alpha-MSH; Amino Acid Sequence; Animals; Antisense Elements (Ge

2011
Pentraxin 3 as a potential biomarker of acetaminophen-induced liver injury.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2013, Volume: 65, Issue:1-2

    Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Biomarkers; C-Reactive Prote

2013
Multimodal analgesia including infraclavicular block in perioperative management of upper extremity amputation in neonate.
    Paediatric anaesthesia, 2011, Volume: 21, Issue:12

    Topics: Acetaminophen; Amputation, Surgical; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesth

2011
Changes in mouse liver protein glutathionylation after acetaminophen exposure.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 340, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced

2012
Identification of urinary microRNA profiles in rats that may diagnose hepatotoxicity.
    Toxicological sciences : an official journal of the Society of Toxicology, 2012, Volume: 125, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bio

2012
RETRACTED: Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity.
    Journal of hepatology, 2012, Volume: 56, Issue:5

    Topics: Acetaminophen; Adult; Alanine Transaminase; Apoptosis; Biomarkers; Case-Control Studies; Chemical an

2012
Complement activation in acetaminophen-induced liver injury in mice.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 341, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Complement Act

2012
The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation.
    The Journal of clinical investigation, 2012, Volume: 122, Issue:4

    Topics: Acetaminophen; Adult; Aged; Alanine Transaminase; Animals; Biomarkers; Caspase 3; Chemical and Drug

2012
P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice.
    American journal of physiology. Gastrointestinal and liver physiology, 2012, May-15, Volume: 302, Issue:10

    Topics: Acetaminophen; Animals; Antigens, CD; Antipyretics; Apyrase; Cells, Cultured; Chemical and Drug Indu

2012
Nasopharyngeal necrosis after chronic opioid (oxycodone/acetaminophen) insufflation.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2012, Volume: 8, Issue:2

    Topics: Acetaminophen; Adult; Drug Combinations; Female; Humans; Insufflation; Nasopharynx; Necrosis; Oxycod

2012
The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury.
    Environmental toxicology and pharmacology, 2012, Volume: 34, Issue:1

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases;

2012
Role of galectin-3 in acetaminophen-induced hepatotoxicity and inflammatory mediator production.
    Toxicological sciences : an official journal of the Society of Toxicology, 2012, Volume: 127, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biotransformation; Chemical and Drug Induced Liver

2012
Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure.
    Hepatology (Baltimore, Md.), 2012, Volume: 56, Issue:5

    Topics: Acetaminophen; Acute Lung Injury; Acute-Phase Reaction; Adolescent; Adult; Analysis of Variance; Ani

2012
Biochemical and histologic presentations of female Wistar rats administered with different doses of paracetamol/methionine.
    Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, 2011, Dec-20, Volume: 26, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Female; Li

2011
Mitogen-activated protein kinase phosphatase (Mkp)-1 protects mice against acetaminophen-induced hepatic injury.
    Toxicologic pathology, 2012, Volume: 40, Issue:8

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Apoptosis; Chemical and Drug

2012
Dietary fish oil aggravates paracetamol-induced liver injury in mice.
    JPEN. Journal of parenteral and enteral nutrition, 2013, Volume: 37, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li

2013
Intranasal hydrocodone-acetaminophen abuse induced necrosis of the nasal cavity and pharynx.
    The Laryngoscope, 2012, Volume: 122, Issue:11

    Topics: Acetaminophen; Administration, Intranasal; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroid

2012
ARC is a novel therapeutic approach against acetaminophen-induced hepatocellular necrosis.
    Journal of hepatology, 2013, Volume: 58, Issue:2

    Topics: Acetaminophen; Animals; Apoptosis Regulatory Proteins; Carcinoma, Hepatocellular; Disease Models, An

2013
Mouse liver protein sulfhydryl depletion after acetaminophen exposure.
    The Journal of pharmacology and experimental therapeutics, 2013, Volume: 344, Issue:1

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li

2013
A reproducible, clinically relevant, intensively managed, pig model of acute liver failure for testing of therapies aimed to prolong survival.
    Liver international : official journal of the International Association for the Study of the Liver, 2013, Volume: 33, Issue:4

    Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Animals; Biomarkers; Cardiovascular Diseases; Chemic

2013
Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antidotes; Chemical and Drug

2002
Protection against acetaminophen hepatotoxicity by clofibrate pretreatment: role of catalase induction.
    Journal of biochemical and molecular toxicology, 2002, Volume: 16, Issue:5

    Topics: Acetaminophen; Administration, Oral; Amitrole; Analgesics, Non-Narcotic; Animals; Bile; Catalase; Ch

2002
Mechanistic pathways of antioxidant cytoprotection by a novel IH636 grape seed proanthocyanidin extract.
    Indian journal of experimental biology, 2002, Volume: 40, Issue:6

    Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Amiodarone; Analgesics, Non-Narcotic; Ani

2002
Role of p55 tumor necrosis factor receptor 1 in acetaminophen-induced antioxidant defense.
    American journal of physiology. Gastrointestinal and liver physiology, 2003, Volume: 285, Issue:5

    Topics: Acetaminophen; Alanine Transaminase; Animals; Antigens, CD; Antioxidants; Enzyme Induction; Glutathi

2003
Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation.
    Toxicological sciences : an official journal of the Society of Toxicology, 2003, Volume: 75, Issue:2

    Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Chemi

2003
Role of lipid peroxidation as a mechanism of liver injury after acetaminophen overdose in mice.
    Toxicological sciences : an official journal of the Society of Toxicology, 2003, Volume: 76, Issue:1

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Diet; Drug Overdose; Enzyme

2003
Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants.
    Toxicology and applied pharmacology, 2003, Sep-15, Volume: 191, Issue:3

    Topics: Acetaminophen; Animals; Blotting, Western; Calpain; Carbon Tetrachloride; Carrier Proteins; Chemical

2003
Effect of a potent iNOS inhibitor (ONO-1714) on acetaminophen-induced hepatotoxicity in the rat.
    Life sciences, 2003, Dec-26, Volume: 74, Issue:6

    Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Amidines; Analgesics, Non-Narcotic; Anima

2003
Effects of acetaminophen on myocardial infarct size in rats.
    Journal of cardiovascular pharmacology and therapeutics, 2003, Volume: 8, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Blood Pressure; Body Temperature; Disease Models,

2003
Chronic liver disease in murine hereditary tyrosinemia type 1 induces resistance to cell death.
    Hepatology (Baltimore, Md.), 2004, Volume: 39, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Cell Survival; Central Nervous System D

2004
Liver necrosis and fulminant hepatic failure in rats: protection by oxyanionic form of tungsten.
    Biochimica et biophysica acta, 2004, Apr-05, Volume: 1688, Issue:3

    Topics: Acetaminophen; Alkaline Phosphatase; Allopurinol; Animals; Bromobenzenes; Carbon Tetrachloride Poiso

2004
N-acetylcysteine does not protect HepG2 cells against acetaminophen-induced apoptosis.
    Basic & clinical pharmacology & toxicology, 2004, Volume: 94, Issue:5

    Topics: Acetaminophen; Acetylcysteine; Antioxidants; Apoptosis; Calcium; Cations, Divalent; Cell Line, Tumor

2004
S-Adenosylmethionine protects against acetaminophen-induced hepatotoxicity in mice.
    Pharmacology, 2004, Volume: 71, Issue:4

    Topics: Acetaminophen; Analgesics; Animals; Cell Membrane Permeability; Chemical and Drug Induced Liver Inju

2004
Acetaminophen and myocardial infarction in dogs.
    American journal of physiology. Heart and circulatory physiology, 2004, Volume: 287, Issue:5

    Topics: Acetaminophen; Animals; Cardiotonic Agents; Collateral Circulation; Coronary Circulation; Dogs; Elec

2004
Inhibition of matrix metalloproteinases minimizes hepatic microvascular injury in response to acetaminophen in mice.
    Toxicological sciences : an official journal of the Society of Toxicology, 2005, Volume: 83, Issue:1

    Topics: Acetaminophen; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Enzyme Inhibit

2005
Increased plasma biotinidase activity in rats with paracetamol-induced acute liver injury.
    Clinica chimica acta; international journal of clinical chemistry, 2004, Volume: 349, Issue:1-2

    Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Albumins; Analgesics, Non-Narcotic; Animals; Bio

2004
Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes.
    Hepatology (Baltimore, Md.), 2004, Volume: 40, Issue:5

    Topics: Acetaminophen; Adenosine Triphosphate; Analgesics, Non-Narcotic; Animals; Apoptosis; Caspase 3; Casp

2004
Long-term acetaminophen (paracetamol) treatment causes liver and kidney ultra-structural changes during rat pregnancy.
    Clinical and experimental obstetrics & gynecology, 2004, Volume: 31, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Drug Administration Schedule; Endoplasmic Reticulu

2004
The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity.
    Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:3

    Topics: Acetaminophen; Acetone; Analgesics, Non-Narcotic; Animals; Cytochrome P-450 CYP2E1; Enzyme Induction

2005
Pathophysiological role of poly(ADP-ribose) polymerase (PARP) activation during acetaminophen-induced liver cell necrosis in mice.
    Toxicological sciences : an official journal of the Society of Toxicology, 2005, Volume: 84, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzamides; Biotransformation; Chemical and Drug I

2005
Protective effect of alpha- and beta-amyrin, a triterpene mixture from Protium heptaphyllum (Aubl.) March. trunk wood resin, against acetaminophen-induced liver injury in mice.
    Journal of ethnopharmacology, 2005, Apr-08, Volume: 98, Issue:1-2

    Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bur

2005
Transcriptional profiling of the left and median liver lobes of male f344/n rats following exposure to acetaminophen.
    Toxicologic pathology, 2005, Volume: 33, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Gene Expression

2005
Distinct roles of NF-kappaB p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity.
    Toxicology and applied pharmacology, 2006, Mar-01, Volume: 211, Issue:2

    Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Blotting, We

2006
Geranylgeranylacetone protects against acetaminophen-induced hepatotoxicity by inducing heat shock protein 70.
    Toxicology, 2006, Feb-15, Volume: 219, Issue:1-3

    Topics: Acetaminophen; Alanine Transaminase; Ammonia; Analgesics, Non-Narcotic; Animals; Anti-Ulcer Agents;

2006
Deoxyribonuclease 1 aggravates acetaminophen-induced liver necrosis in male CD-1 mice.
    Hepatology (Baltimore, Md.), 2006, Volume: 43, Issue:2

    Topics: Acetaminophen; Adenosine Triphosphate; Animals; Chemical and Drug Induced Liver Injury; Deoxyribonuc

2006
Hepatoprotective activity of Psidium guajava Linn. leaf extract.
    Indian journal of experimental biology, 2006, Volume: 44, Issue:4

    Topics: Acetaminophen; Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver

2006
Effect of hexane extract of Boswellia serrata oleo-gum resin on chemically induced liver damage.
    Pakistan journal of pharmaceutical sciences, 2006, Volume: 19, Issue:2

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Boswellia; Carbon Tetrachloride; Chemical and Drug

2006
Peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP) but not PPAR-interacting protein (PRIP) is required for nuclear translocation of constitutive androstane receptor in mouse liver.
    Biochemical and biophysical research communications, 2006, Aug-25, Volume: 347, Issue:2

    Topics: Acetaminophen; Active Transport, Cell Nucleus; Adenoviridae; Animals; Blotting, Northern; Cell Nucle

2006
Pre-exposure to a novel nutritional mixture containing a series of phytochemicals prevents acetaminophen-induced programmed and unprogrammed cell deaths by enhancing BCL-XL expression and minimizing oxidative stress in the liver.
    Molecular and cellular biochemistry, 2006, Volume: 293, Issue:1-2

    Topics: Acetaminophen; Animals; Apoptosis; bcl-X Protein; Cell Proliferation; Dietary Supplements; DNA Fragm

2006
Artefactual contraction band necrosis of the myocardium in fatal air crashes.
    Aviation, space, and environmental medicine, 2006, Volume: 77, Issue:9

    Topics: Accidents, Aviation; Acetaminophen; Adult; Anabolic Agents; Analgesics, Non-Narcotic; Cannabinoids;

2006
Recombinant platelet-activating factor-acetylhydrolase attenuates paracetamol-induced liver oxidative stress, injury, and regeneration.
    Digestive diseases and sciences, 2007, Volume: 52, Issue:1

    Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Acetaminophen; Analgesics, Non-Narcotic; Animals; Li

2007
Mild hypothermia attenuates liver injury and improves survival in mice with acetaminophen toxicity.
    Gastroenterology, 2007, Volume: 132, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Body Temperature; Cell Count; Cell Divi

2007
Gene expression analysis offers unique advantages to histopathology in liver biopsy evaluations.
    Toxicologic pathology, 2007, Volume: 35, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biopsy; Cytochrome P-450 Enzyme System; Dose-Respo

2007
Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury.
    Hepatology (Baltimore, Md.), 2007, Volume: 45, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; bcl-X Protein; Enzyme Inhibitors; Immun

2007
Rhabdomyolysis and necrotic bowel after acetaminophen and ibuprofen overdose.
    Pharmacotherapy, 2007, Volume: 27, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Blood Chemical Analysis; Drug Overdose; Humans; Ibup

2007
Simultaneous clustering of gene expression data with clinical chemistry and pathological evaluations reveals phenotypic prototypes.
    BMC systems biology, 2007, Feb-23, Volume: 1

    Topics: Acetaminophen; Algorithms; Animals; Clinical Chemistry Tests; Cluster Analysis; Data Interpretation,

2007
Sensitivity of (1)H NMR analysis of rat urine in relation to toxicometabonomics. Part I: dose-dependent toxic effects of bromobenzene and paracetamol.
    Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 98, Issue:1

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases;

2007
Specific activation of the different fibrogenic cells in rat cultured liver slices mimicking in vivo situations.
    Virchows Archiv : an international journal of pathology, 2007, Volume: 450, Issue:5

    Topics: Acetaminophen; Acetylcysteine; Animal Use Alternatives; Animals; Antioxidants; Bile Ducts, Intrahepa

2007
Chromatin breakdown by deoxyribonuclease1 promotes acetaminophen-induced liver necrosis: an ultrastructural and histochemical study on male CD-1 mice.
    Histochemistry and cell biology, 2007, Volume: 128, Issue:1

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases;

2007
Role of apoptosis in acetaminophen hepatotoxicity.
    Journal of gastroenterology and hepatology, 2007, Volume: 22 Suppl 1

    Topics: Acetaminophen; Animals; Apoptosis; Cell Membrane Permeability; Cells, Cultured; Chemical and Drug In

2007
Hepatic injury induces contrasting response in liver and kidney to chemicals that are metabolically activated: role of male sex hormone.
    Toxicology and applied pharmacology, 2007, Aug-15, Volume: 223, Issue:1

    Topics: Acetaminophen; Aminopyrine N-Demethylase; Animals; Biotransformation; Carbon Tetrachloride; Chemical

2007
Hepatoprotective effect of L-carnitine against acute acetaminophen toxicity in mice.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2007, Volume: 59, Issue:2

    Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Ami

2007
Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 324, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; bcl-2-Associated X Protein; Chemical and Drug Indu

2008
Complete soft palate necrosis and velopharyngeal insufficiency resulting from intranasal inhalation of prescription narcotics and cocaine.
    The Journal of craniofacial surgery, 2007, Volume: 18, Issue:6

    Topics: Acetaminophen; Administration, Inhalation; Adult; Analgesics, Opioid; Cocaine; Cocaine-Related Disor

2007
The release of DNA into the plasma of mice following hepatic cell death by apoptosis and necrosis.
    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2008, Volume: 13, Issue:2

    Topics: Acetaminophen; Animals; Apoptosis; Biomarkers; Carbon Tetrachloride; DNA; Female; L-Lactate Dehydrog

2008
Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity.
    Toxicology and applied pharmacology, 2008, Jun-15, Volume: 229, Issue:3

    Topics: Acetaminophen; Animals; Apoptosis; Carbon Tetrachloride; Down-Regulation; Fibrosis; Forecasting; Gli

2008
Cytochrome c: a non-invasive biomarker of drug-induced liver injury.
    Journal of applied toxicology : JAT, 2008, Volume: 28, Issue:7

    Topics: Acetaminophen; Acute Disease; Animals; Apoptosis; Biomarkers; Chemical and Drug Induced Liver Injury

2008
Apoptosis versus necrosis rate as a predictor in acute liver failure following acetaminophen intoxication compared with acute-on-chronic liver failure.
    Liver international : official journal of the International Association for the Study of the Liver, 2008, Volume: 28, Issue:5

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Apoptosis; Biomarkers; Humans; Liver Failure, A

2008
Protection by bicyclol derivatives against acetaminophen-induced acute liver failure in mice and its active mechanism.
    Liver international : official journal of the International Association for the Study of the Liver, 2008, Volume: 28, Issue:9

    Topics: Acetaminophen; Adenosine Triphosphate; Analgesics, Non-Narcotic; Animals; Apoptosis; Apoptosis Induc

2008
Human hepatocytes can repopulate mouse liver: histopathology of the liver in human hepatocyte-transplanted chimeric mice and toxicologic responses to acetaminophen.
    Toxicologic pathology, 2008, Volume: 36, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Cell Proliferation; Female; Hepatocytes

2008
Plasminogen activator inhibitor-1 limits liver injury and facilitates regeneration after acetaminophen overdose.
    Toxicological sciences : an official journal of the Society of Toxicology, 2008, Volume: 104, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Li

2008
Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008, Aug-15, Volume: 871, Issue:2

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid

2008
Effects of acetaminophen on hepatic gene expression in mice.
    Physiological chemistry and physics and medical NMR, 2006, Volume: 38, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Dose-Response Relationshi

2006
Drugs and the liver.
    Comprehensive therapy, 1984, Volume: 10, Issue:12

    Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv

1984
Cardiovascular lesions in Sprague-Dawley rats induced by long-term treatment with caffeine.
    Acta pathologica et microbiologica Scandinavica. Section A, Pathology, 1981, Volume: 89, Issue:3

    Topics: Acetaminophen; Animals; Antipyrine; Caffeine; Cardiovascular Diseases; Heart; Male; Myocardial Infar

1981
Drug-induced lipid peroxidation in mice--II. Protection against paracetamol-induced liver necrosis by intravenous liposomally entrapped glutathione.
    Biochemical pharmacology, 1982, Nov-15, Volume: 31, Issue:22

    Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Benzo(a)pyrene; Benzopyrenes; Chemical and Drug

1982
Examination of the protective effect of ICRF-187 and dimethyl sulfoxide against acetaminophen-induced hepatotoxicity in Syrian golden hamsters.
    Toxicology, 1983, Volume: 28, Issue:4

    Topics: Acetaminophen; Alanine Transaminase; Animals; Blood Proteins; Chemical and Drug Induced Liver Injury

1983
The role of metabolic activation of analgesics and non-steroidal anti-inflammatory drugs in the development of renal papillary necrosis and upper urothelial carcinoma.
    Prostaglandins, leukotrienes, and medicine, 1984, Volume: 15, Issue:2

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; B

1984
Protective action of 2(3)-tert-butyl-4-hydroxyanisole (BHA) on acetaminophen-induced liver necrosis in male A/J mice.
    Research communications in chemical pathology and pharmacology, 1984, Volume: 46, Issue:3

    Topics: Acetaminophen; Animals; Anisoles; Butylated Hydroxyanisole; Chemical and Drug Induced Liver Injury;

1984
Acute liver failure and encephalopathy in a 15-month-old infant.
    American journal of diseases of children (1960), 1983, Volume: 137, Issue:11

    Topics: Acetaminophen; Acute Disease; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Diagnosis, Dif

1983
Histological & ultrastructural alterations in the livers of albino rats after prolonged administration of paracetamol.
    The Indian journal of medical research, 1983, Volume: 77

    Topics: Acetaminophen; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Liver;

1983
Reversal of acetaminophen intoxication with an N-acetylcysteine-liposome preparation.
    Research communications in chemical pathology and pharmacology, 1983, Volume: 42, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Animals; Lethal Dose 50; Liposomes; Liver; Male; Mice; Necrosis

1983
Scanning electron microscopic examination of acetaminophen-induced hepatotoxicity and congestion in mice.
    The American journal of pathology, 1983, Volume: 113, Issue:3

    Topics: Acetaminophen; Animals; Cell Membrane; Chemical and Drug Induced Liver Injury; Erythrocytes; Liver;

1983
Fatal acetaminophen toxicity in a 2-year-old.
    The Journal of the Indiana State Medical Association, 1983, Volume: 76, Issue:12

    Topics: Acetaminophen; Antidotes; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; H

1983
Potentiation of the toxic effects of acetaminophen in mice by concurrent infection with influenza B virus: a possible mechanism for human Reye's syndrome?
    Pediatric research, 1984, Volume: 18, Issue:2

    Topics: Acetaminophen; Animals; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Ind

1984
Quantitative liver function and morphology after paracetamol administration to rats.
    European journal of clinical investigation, 1981, Volume: 11, Issue:3

    Topics: Acetaminophen; Animals; Fatty Liver; Female; Galactose; Lethal Dose 50; Liver; Necrosis; Prothrombin

1981
Severe hepatic damage after acetaminophen use in psittacosis.
    The American journal of medicine, 1983, Volume: 74, Issue:2

    Topics: Acetaminophen; Humans; Liver; Liver Diseases; Male; Middle Aged; Necrosis; Psittacosis

1983
[Hepatic lesion caused by acetaminophen. Apropos of a case with unusual portal involvement].
    Revista clinica espanola, 1983, Mar-15, Volume: 168, Issue:5

    Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Inflammation; Male; Middle Aged; Necr

1983
The predictive value of changes in antipyrine pharmacokinetics in halothane and paracetamol induced hepatic necrosis in rats.
    Research communications in chemical pathology and pharmacology, 1983, Volume: 40, Issue:2

    Topics: Acetaminophen; Animals; Antipyrine; Chemical and Drug Induced Liver Injury; Half-Life; Halothane; Ki

1983
Glutathione thresholds in reactive metabolite toxicity.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1980, Volume: 3

    Topics: Acetaminophen; Animals; Biotransformation; Bromobenzenes; Cricetinae; Dose-Response Relationship, Dr

1980
Paracetamol poisoning--hepatic protection by n-acetylcysteine.
    Irish journal of medical science, 1982, Volume: 151, Issue:11

    Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Cystine; Humans; Male; Necrosis

1982
Bacteraemia in patients with fulminant hepatic failure.
    Liver, 1982, Volume: 2, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; H

1982
Prevention of acetaminophen-induced hepatic necrosis by cimetidine in mice.
    Research communications in chemical pathology and pharmacology, 1981, Volume: 32, Issue:2

    Topics: Acetaminophen; Animals; Cimetidine; Female; Guanidines; Liver; Mice; Necrosis

1981
Cimetidine protects against acetaminophen hepatotoxicity in rats.
    Gastroenterology, 1981, Volume: 81, Issue:6

    Topics: Acetaminophen; Alanine Transaminase; Aminopyrine; Animals; Aspartate Aminotransferases; Chemical and

1981
Hepatotoxicity of phenacetin and paracetamol in the Gunn rat.
    Pathology, 1981, Volume: 13, Issue:4

    Topics: Acetaminophen; Animals; Female; Liver; Necrosis; Nephritis, Interstitial; Phenacetin; Rats; Rats, Gu

1981
Mechanism of the protective effect of propylthiouracil against acetaminophen (Tylenol) toxicity in the rat.
    Gastroenterology, 1980, Volume: 78, Issue:1

    Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced

1980
Acetaminophen-induced hepatotoxicity in mice.
    Laboratory investigation; a journal of technical methods and pathology, 1980, Volume: 42, Issue:2

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver; Male; Mice; Necrosis

1980
Apparent potentiation of acetaminophen hepatotoxicity by alcohol.
    Annals of internal medicine, 1980, Volume: 92, Issue:4

    Topics: Acetaminophen; Drug Synergism; Ethanol; Humans; Jaundice; Liver; Male; Middle Aged; Necrosis

1980
Potentiation of acetaminophen hepatotoxicity by alcohol.
    JAMA, 1980, Jul-18, Volume: 244, Issue:3

    Topics: Acetaminophen; Adult; Alcoholism; Drug Synergism; Ethanol; Humans; Liver; Male; Middle Aged; Necrosi

1980
N-Acetyl-DL-penicillamine and acetaminophen toxicity in mice.
    Journal of pharmaceutical sciences, 1980, Volume: 69, Issue:9

    Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Male; Mice; Necrosis

1980
Effectiveness of methyrapone in the treatment of acetaminophen toxicity in mice.
    Toxicology, 1980, Volume: 17, Issue:1

    Topics: Acetaminophen; Animals; Female; Glutathione; Lethal Dose 50; Liver; Metyrapone; Mice; Necrosis; Time

1980
An integrated approach to the study of chemically reactive metabolites of acetaminophen.
    Archives of internal medicine, 1981, Feb-23, Volume: 141, Issue:3 Spec No

    Topics: Acetaminophen; Animals; Antidotes; Biotransformation; Cricetinae; Cysteamine; Cysteine; Dose-Respons

1981
Comparison of thermally oxidized lipids and acetaminophen with concurrent consumption of ethanol as inducers of liver cirrhosis.
    Journal of toxicology and environmental health, 1995, Volume: 46, Issue:2

    Topics: Acetaminophen; Acute-Phase Reaction; Analysis of Variance; Animals; Benzoquinones; DNA; Drug Interac

1995
Protective effect of oleanolic acid against chemical-induced acute necrotic liver injury in mice.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1995, Volume: 16, Issue:2

    Topics: Acetaminophen; Animals; Cadmium Poisoning; Carbon Tetrachloride Poisoning; Chemical and Drug Induced

1995
[A case of paracetamol retard poisoning with fatal outcome].
    Ugeskrift for laeger, 1995, Feb-13, Volume: 157, Issue:7

    Topics: Acetaminophen; Adult; Delayed-Action Preparations; Drug Overdose; Fatal Outcome; Female; Humans; Liv

1995
Immunohistochemical localization of acetaminophen in target tissues of the CD-1 mouse: correspondence of covalent binding with toxicity.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1995, Volume: 24, Issue:2

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cytochrome

1995
Clofibrate pretreatment diminishes acetaminophen's selective covalent binding and hepatotoxicity.
    Toxicology and applied pharmacology, 1994, Volume: 129, Issue:2

    Topics: Acetaminophen; Analysis of Variance; Animals; Blotting, Western; Carrier Proteins; Clofibrate; Cytoc

1994
Non-parenchymal cell responses in paracetamol (acetaminophen)-induced liver injury.
    Journal of hepatology, 1994, Volume: 20, Issue:4

    Topics: Acetaminophen; Biopsy; Cell Count; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Hu

1994
Investigation of possible mechanisms of hepatic swelling and necrosis caused by acetaminophen in mice.
    Biochemical pharmacology, 1993, Jan-26, Volume: 45, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Animals; Cell Adhesion Molecules; Intercellular Adhesion Molecu

1993
4-Methylpyrazole blocks acetaminophen hepatotoxicity in the rat.
    Annals of emergency medicine, 1994, Volume: 23, Issue:3

    Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Dose-Response Relationshi

1994
Misoprostol protection against acetaminophen-induced hepatotoxicity in the rat.
    Digestive diseases and sciences, 1994, Volume: 39, Issue:6

    Topics: Acetaminophen; Alanine Transaminase; Animals; Disease Models, Animal; Drug Overdose; Liver; Male; Mi

1994
The role of transjugular liver biopsy in fulminant liver failure: relation to other prognostic indicators.
    Hepatology (Baltimore, Md.), 1993, Volume: 18, Issue:6

    Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Biopsy; Chi-Square Distribution; Child; C

1993
Effect of thiola on acetaminophen induced hepatic necrosis in mice.
    Bulletin of environmental contamination and toxicology, 1993, Volume: 51, Issue:6

    Topics: Acetaminophen; Animals; Behavior, Animal; Chemical and Drug Induced Liver Injury; Drug Interactions;

1993
Cytochrome P450 and glutathione in the liver of rats under exclusive sucrose ingestion.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1993, Volume: 26, Issue:9

    Topics: Acetaminophen; Animals; Antipyrine; Body Weight; Cholesterol Side-Chain Cleavage Enzyme; Fasting; Gl

1993
Phenylpropanolamine potentiation of acetaminophen-induced hepatotoxicity: evidence for a glutathione-dependent mechanism.
    Toxicology and applied pharmacology, 1993, Volume: 118, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Animals; Dose-Response Relationship, Drug; Drug Synergism; Glut

1993
Ca2+ antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1993, Volume: 7, Issue:5

    Topics: Acetaminophen; Animals; Biotransformation; Calcium; Calcium Channel Blockers; Cell Death; Chlorproma

1993
Fulminant hepatitis associated with centrilobular hepatic necrosis in young children.
    The Journal of pediatrics, 1995, Volume: 127, Issue:6

    Topics: Acetaminophen; Child, Preschool; Female; Fever; Hepatic Encephalopathy; Humans; Infant; Liver; Male;

1995
[Plasma levels of alanine aminotransferase in experimental liver necrosis induced by overdosage of paracetamol in mice].
    Revista espanola de enfermedades digestivas, 1995, Volume: 87, Issue:12

    Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Female; Liver;

1995
Acute hepatotoxicity of acetaminophen in rats treated with ethanol plus isopentanol.
    Biochemical pharmacology, 1995, Nov-27, Volume: 50, Issue:11

    Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug In

1995
Hepatoprotective effects of the shark bile salt 5beta-scymnol on acetaminophen-induced liver damage in mice.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1996, Volume: 33, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Bile Acids and Salts; Chemical and Dru

1996
Acetaminophen-induced hepatotoxicity is associated with early changes in AP-1 DNA binding activity.
    Research communications in molecular pathology and pharmacology, 1996, Volume: 92, Issue:3

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dimerization; DNA; Female; Gene Expr

1996
Morphology of hepatic stellate cells in patients with fulminant or subfulminant hepatitis requiring liver transplantation.
    Journal of submicroscopic cytology and pathology, 1996, Volume: 28, Issue:1

    Topics: Acetaminophen; Actins; Adult; Aged; Amanita; Autoimmune Diseases; Biomarkers; Cell Differentiation;

1996
Increased resistance to acetaminophen-induced hepatotoxicity in retrovirus-infected mice.
    Biopharmaceutics & drug disposition, 1996, Volume: 17, Issue:8

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biotransformation; Chemical and Drug Induced Liver

1996
Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 279, Issue:3

    Topics: Acetaminophen; Animals; Apoptosis; Cholesterol Esters; DNA Fragmentation; Liver; Male; Mice; Microsc

1996
Hepatic necrosis masquerading as trauma.
    Pediatric radiology, 1997, Volume: 27, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Child, Preschool; Diagnosis, Differential; Humans; Liver; M

1997
Correlation between the severity of acute hepatic necrosis induced by acetaminophen and serum aminotransferase levels in fasted and sucrose-fed rats.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1996, Volume: 29, Issue:6

    Topics: Acetaminophen; Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical a

1996
Calcium-dependent DNA damage and adenosine 3',5'-cyclic monophosphate-independent glycogen phosphorylase activation in an in vitro model of acetaminophen-induced liver injury.
    Hepatology (Baltimore, Md.), 1997, Volume: 25, Issue:6

    Topics: Acetaminophen; Animals; Calcium; Cell Death; Cells, Cultured; Chemical and Drug Induced Liver Injury

1997
Cimetidine enhances the hepatoprotective action of N-acetylcysteine in mice treated with toxic doses of paracetamol.
    Toxicology, 1997, Sep-05, Volume: 121, Issue:3

    Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alanine Transaminase; Analgesics, Non-Narcotic;

1997
[Fatal acute liver damage caused by a therapeutic dose of paracetamol].
    Orvosi hetilap, 1998, Jan-25, Volume: 139, Issue:4

    Topics: Acetaminophen; Adolescent; Chemical and Drug Induced Liver Injury; Child, Preschool; Dose-Response R

1998
Emergency! Acetaminophen overdose.
    The American journal of nursing, 1998, Volume: 98, Issue:3

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anorexia Nervosa; Chemical and Drug Induced Liv

1998
The effects of glutathione glycoside in acetaminophen-induced liver cell necrosis.
    Experimental and molecular pathology, 1998, Volume: 65, Issue:1

    Topics: Acetaminophen; Animals; Drug Overdose; Glutathione; Glycosides; Humans; Lipid Peroxidation; Liver; M

1998
Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice.
    Toxicology and applied pharmacology, 1998, Volume: 152, Issue:1

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Cytochrome P-450 CYP1A2; Cyt

1998
Comparison of paracetamol-induced hepatotoxicity in the rat in vivo with progression of cell injury in vitro in rat liver slices.
    Drug and chemical toxicology, 1998, Volume: 21, Issue:4

    Topics: Acetaminophen; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cytochrome P-450 Enzyme Syste

1998
Role of neutrophils in hepatotoxicity induced by oral acetaminophen administration in rats.
    The Journal of surgical research, 1998, Volume: 80, Issue:2

    Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Antibodies; Liver; Male; Necrosi

1998
Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species.
    Hepatology (Baltimore, Md.), 1999, Volume: 30, Issue:1

    Topics: Acetaminophen; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases;

1999
Hypothyroidism protects rat liver from acetaminophen hepatotoxicity.
    Digestive diseases and sciences, 1999, Volume: 44, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Chemical and Drug Induced Li

1999
A novel proanthocyanidin IH636 grape seed extract increases in vivo Bcl-XL expression and prevents acetaminophen-induced programmed and unprogrammed cell death in mouse liver.
    Archives of biochemistry and biophysics, 1999, Sep-01, Volume: 369, Issue:1

    Topics: Acetaminophen; Alanine Transaminase; Animals; Anthocyanins; Antioxidants; Apoptosis; bcl-X Protein;

1999
Macrophage inflammatory protein-2 gene therapy attenuates adenovirus- and acetaminophen-mediated hepatic injury.
    Gene therapy, 1999, Volume: 6, Issue:4

    Topics: Acetaminophen; Acute Disease; Adenoviridae; Animals; Chemokine CXCL2; Female; Gene Expression; Genet

1999
[Hepatoprotective effect of flower pollen lipid extract in paracetamol-induced hepatotoxicity in mice].
    Folia medica Cracoviensia, 1997, Volume: 38, Issue:3-4

    Topics: Acetaminophen; Animals; Cytoprotection; Lipids; Liver; Male; Mice; Mitochondria; Necrosis; Organelle

1997
The canals of Hering and hepatic stem cells in humans.
    Hepatology (Baltimore, Md.), 1999, Volume: 30, Issue:6

    Topics: Acetaminophen; Adult; Aged; alpha-Fetoproteins; Bile Ducts, Intrahepatic; Biomarkers; Female; Humans

1999
A hepatotoxic dose of acetaminophen modulates expression of BCL-2, BCL-X(L), and BCL-X(S) during apoptotic and necrotic death of mouse liver cells in vivo.
    Archives of toxicology, 2000, Volume: 73, Issue:10-11

    Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; bcl-X Protein; Blotting, Western; Cell Nucl

2000
Western blot analysis for nitrotyrosine protein adducts in livers of saline-treated and acetaminophen-treated mice.
    Toxicological sciences : an official journal of the Society of Toxicology, 2000, Volume: 53, Issue:2

    Topics: Acetaminophen; Adjuvants, Immunologic; Analgesics, Non-Narcotic; Animals; Blotting, Western; Cattle;

2000
Inhibition of tumour necrosis factor alpha does not prevent experimental paracetamol-induced hepatic necrosis.
    The Journal of pathology, 2000, Volume: 190, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Enzyme-Linked Immunos

2000
Exaggerated hepatic injury due to acetaminophen challenge in mice lacking C-C chemokine receptor 2.
    The American journal of pathology, 2000, Volume: 156, Issue:4

    Topics: Acetaminophen; Animals; Antibodies; Apoptosis; Chemical and Drug Induced Liver Injury; Chemokine CCL

2000
The hepatic inflammatory response after acetaminophen overdose: role of neutrophils.
    Toxicological sciences : an official journal of the Society of Toxicology, 2000, Volume: 54, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; CD18 Antigens; Chemokines, CXC; Drug Overdose; Flo

2000
Effect of Azadirachta indica (Neem) leaf aqueous extract on paracetamol-induced liver damage in rats.
    Indian journal of physiology and pharmacology, 2000, Volume: 44, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Glycerides

2000
Peroxisome proliferator-activated receptor alpha-null mice lack resistance to acetaminophen hepatotoxicity following clofibrate exposure.
    Toxicological sciences : an official journal of the Society of Toxicology, 2000, Volume: 57, Issue:2

    Topics: Acetaminophen; Administration, Oral; Analgesics; Animals; Chemical and Drug Induced Liver Injury; Cl

2000
In vivo protection of dna damage associated apoptotic and necrotic cell deaths during acetaminophen-induced nephrotoxicity, amiodarone-induced lung toxicity and doxorubicin-induced cardiotoxicity by a novel IH636 grape seed proanthocyanidin extract.
    Research communications in molecular pathology and pharmacology, 2000, Volume: 107, Issue:1-2

    Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Amiodarone; Animals; Antioxidants; Apopto

2000
Role of taurine in preventing acetaminophen-induced hepatic injury in the rat.
    American journal of physiology. Gastrointestinal and liver physiology, 2001, Volume: 280, Issue:6

    Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Narcotic; Animals; Apopto

2001
Potential role for Duffy antigen chemokine-binding protein in angiogenesis and maintenance of homeostasis in response to stress.
    Journal of leukocyte biology, 2002, Volume: 71, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antigens, Protozoan; Carrier Proteins; Chemokines,

2002
Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis?
    Toxicological sciences : an official journal of the Society of Toxicology, 2002, Volume: 67, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; Blotting, Western; Caspase 3; Caspases; Foo

2002
Comparison of the therapeutic efficacy of 4-methylpyrazole and N-acetylcysteine on acetaminophen (paracetamol) hepatotoxicity in rats.
    Current medical research and opinion, 2002, Volume: 18, Issue:2

    Topics: Acetaminophen; Acetylcysteine; Alcohol Dehydrogenase; Analgesics, Non-Narcotic; Animals; Antidotes;

2002
Effects of "Chinese yam" on hepato-nephrotoxicity of acetaminophen in rats.
    Acta pharmacologica Sinica, 2002, Volume: 23, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Dioscorea;

2002
Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes.
    Hepatology (Baltimore, Md.), 2002, Volume: 36, Issue:1

    Topics: Acetaminophen; Animals; Antioxidants; Apoptosis; Butylated Hydroxytoluene; Caspase Inhibitors; Caspa

2002
Letter: Paracetamol hepatoxicity.
    Lancet (London, England), 1976, Feb-14, Volume: 1, Issue:7955

    Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Humans; Liver; Necrosis

1976
Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning.
    Lancet (London, England), 1976, Jul-17, Volume: 2, Issue:7977

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury;

1976
Chronic hepatic inflammation and fibrosis due to low doses of paracetamol.
    Lancet (London, England), 1978, May-13, Volume: 1, Issue:8072

    Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chronic Disease; Hip Joint; Humans; Joint Dis

1978
Experimental acetaminophen-induced hepatic necrosis: biochemical and electron microscopic study of cysteamine protection.
    Laboratory investigation; a journal of technical methods and pathology, 1978, Volume: 39, Issue:3

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cricetinae; Cysteamine; Electron Tra

1978
Prevention of paracetamol-induced liver damage in mice with glutathione.
    The Journal of pharmacy and pharmacology, 1975, Volume: 27, Issue:8

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Gl

1975
Clinical and experimental aspects of paracetamol hepatotoxicity.
    Acta pharmacologica et toxicologica, 1977, Volume: 41 Suppl 2

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Humans; Liver; Necrosis

1977
Experimental hepatic injury: the sequential changes in drug metabolizing enzyme activities after administration of acetaminophen.
    Research communications in chemical pathology and pharmacology, 1977, Volume: 16, Issue:1

    Topics: Acetaminophen; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Chemical and Drug Induced Li

1977
Hyperthermia and rhabdomyolysis in self-poisoning with paracetamol and salicylates. Report of a case.
    Acta medica Scandinavica, 1979, Volume: 205, Issue:6

    Topics: Acetaminophen; Adult; Female; Fever; Humans; Muscles; Muscular Diseases; Myoglobinuria; Necrosis; Sa

1979
Cocaine-induced hepatic necrosis in mice--the role of cocaine metabolism.
    Biochemical pharmacology, 1979, Aug-01, Volume: 28, Issue:15

    Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cocaine

1979
Management of acetaminophen overdose.
    The Journal of the Kentucky Medical Association, 1979, Volume: 77, Issue:9

    Topics: Acetaminophen; Acetylcysteine; Humans; Liver; Necrosis

1979
Paracetamol poisoning. Prevention of liver damage.
    Medecine & chirurgie digestives, 1979, Volume: 8, Issue:5

    Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Necrosis

1979
Acetaminophen and the liver.
    Annals of internal medicine, 1978, Volume: 88, Issue:2

    Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Humans; Liver Cirrhosis; Male; Necrosi

1978
Paracetamol poisoning.
    British medical journal, 1978, Sep-16, Volume: 2, Issue:6140

    Topics: Acetaminophen; Humans; Liver; Mortality; Necrosis; United Kingdom

1978
Decreased toxicity of the N-methyl analogs of acetaminophen and phenacetin.
    Research communications in chemical pathology and pharmacology, 1978, Volume: 22, Issue:1

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cricetinae; Male; Mesocricetus; Meth

1978
Acetaminophen overdose and hepatic necrosis.
    Texas medicine, 1978, Volume: 74, Issue:12

    Topics: Acetaminophen; Female; Humans; Liver; Middle Aged; Necrosis

1978
Evaluation of paracetamol-induced damage in liver biopsies. Acute changes and follow-up findings.
    Virchows Archiv. A, Pathological anatomy and histology, 1976, Jul-21, Volume: 370, Issue:4

    Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Dose-Response Relationship

1976
Acetaminophen and hepatic necrosis.
    The New England journal of medicine, 1977, Jan-27, Volume: 296, Issue:4

    Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Necrosis

1977
Hepatotoxicity of paracetamol enhanced by ingestion of alcohol: report of two cases.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1977, Feb-12, Volume: 51, Issue:7

    Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Cysteamine; Female; Humans

1977
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 23--1977.
    The New England journal of medicine, 1977, Jun-09, Volume: 296, Issue:23

    Topics: Acetaminophen; Acute Disease; Adolescent; Arthritis, Juvenile; Aspirin; Brain Death; Brain Edema; Ch

1977
Acetaminophen toxity.
    American journal of hospital pharmacy, 1977, Volume: 34, Issue:4

    Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Li

1977
Liver function and structure in survivors of acetaminophen poisoning. A follow-up study of serum bile acids and liver histology.
    The American journal of digestive diseases, 1977, Volume: 22, Issue:7

    Topics: Acetaminophen; Aspartate Aminotransferases; Bile Acids and Salts; Chemical and Drug Induced Liver In

1977
Fatal massive hepatic necrosis following acetaminophen overdose.
    JAMA, 1976, Oct-18, Volume: 236, Issue:16

    Topics: Acetaminophen; Adult; Autopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Kidney; Kidne

1976
Editorial: Paracetamol and the liver.
    The New Zealand medical journal, 1976, Mar-10, Volume: 83, Issue:559

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Liver; Liver Dis

1976
The effect of diet on the toxicity of paracetamol and the safety of paracetamol-methionine mixtures.
    Biochemical pharmacology, 1975, Jan-01, Volume: 24, Issue:1

    Topics: Acetaminophen; Animals; Body Weight; Caseins; Chemical and Drug Induced Liver Injury; Cysteine; Cyto

1975
Acetaminophen poisoning and toxicity.
    Pediatrics, 1975, Volume: 55, Issue:6

    Topics: Acetaminophen; Agranulocytosis; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Hypoglyc

1975
Experimental paracetamol-induced hepatic necrosis: a light- and electron-microscope, and histochemical study.
    The Journal of pathology, 1975, Volume: 116, Issue:1

    Topics: Acetaminophen; Acid Phosphatase; Animals; Chemical and Drug Induced Liver Injury; Endoplasmic Reticu

1975
Effect of liposomal entrapment on the protective action of glutathione against paracetamol-induced liver necrosis.
    Biochemical Society transactions, 1975, Volume: 3, Issue:5

    Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Glutathione; Liposomes; L

1975
Serum transaminase levels after experimental paracetamol-induced hepatic necrosis.
    Gut, 1975, Volume: 16, Issue:10

    Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced

1975
Histopathological changes in the liver following a paracetamol overdose: correlation with clinical and biochemical parameters.
    The Journal of pathology, 1975, Volume: 117, Issue:3

    Topics: Acetaminophen; Adolescent; Adult; Bilirubin; Chemical and Drug Induced Liver Injury; Female; Follow-

1975
Why do people use paracetamol for suicide?
    British medical journal, 1976, Jan-24, Volume: 1, Issue:6003

    Topics: Acetaminophen; Drug Prescriptions; Female; Humans; Liver; Male; Necrosis; Nonprescription Drugs; Sui

1976
[Drug induced liver injury. Chemical liver necrosis caused by formation of reactive metabolites].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1976, Feb-10, Volume: 96, Issue:4

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug

1976
Immunolocalization of regenerating cells after submassive liver necrosis using PCNA staining.
    The Journal of pathology, 1992, Volume: 166, Issue:4

    Topics: Acetaminophen; Acute Disease; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Immunoh

1992
Paracetamol toxicity in chronic alcohol abusers--a plea for greater consumer awareness.
    The New Zealand medical journal, 1992, May-13, Volume: 105, Issue:933

    Topics: Acetaminophen; Alcoholism; Gastritis; Health Education; Humans; Liver; Male; Middle Aged; Necrosis

1992
Protective effect of deferoxamine for acetaminophen induced liver injury.
    Gastroenterologia Japonica, 1992, Volume: 27, Issue:3

    Topics: Acetaminophen; Animals; Deferoxamine; Dose-Response Relationship, Drug; Liver; Male; Necrosis; Rats;

1992
Effect of pregnenolone-16 alpha-carbonitrile and dexamethasone on acetaminophen-induced hepatotoxicity in mice.
    Toxicology and applied pharmacology, 1992, Volume: 115, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Animals; Bile; Dexamethasone; Glutathione; L-Iditol 2-Dehydroge

1992
Fatal acetaminophen poisoning with evidence of subendocardial necrosis of the heart.
    Journal of forensic sciences, 1991, Volume: 36, Issue:3

    Topics: Acetaminophen; Adolescent; Drug Overdose; Endocardium; Female; Heart Transplantation; Humans; Kidney

1991
Protective effects of propylene glycol, a solvent used pharmaceutically, against paracetamol-induced liver injury in mice.
    Biochemical pharmacology, 1991, Jul-15, Volume: 42, Issue:3

    Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Blood Glucose; Drug Antagonism; Liver; Male; Mi

1991
Postnatal mice have low susceptibility to paracetamol toxicity.
    Pediatric research, 1991, Volume: 29, Issue:5

    Topics: Acetaminophen; Age Factors; Animals; Animals, Newborn; Benzoquinones; Chemical and Drug Induced Live

1991
Necrotizing myopathy in critically-ill patients.
    The Journal of pathology, 1991, Volume: 164, Issue:4

    Topics: Acetaminophen; Aortic Aneurysm; Bacterial Infections; Critical Care; Eclampsia; Female; Humans; Immu

1991
Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: correlation of nuclear Ca2+ accumulation and early DNA fragmentation with cell death.
    Toxicology and applied pharmacology, 1991, Volume: 111, Issue:2

    Topics: Acetaminophen; Animals; Calcium; Cell Death; Cell Nucleus; DNA; DNA Damage; Liver; Male; Mice; Necro

1991
Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of acetylcysteine.
    Lancet (London, England), 1990, Jun-30, Volume: 335, Issue:8705

    Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adult; Aspartate Aminotransferases; Drug Evaluation; F

1990
Prevention of acetaminophen-induced hepatotoxicity by endotoxin in mice.
    Research communications in chemical pathology and pharmacology, 1990, Volume: 69, Issue:1

    Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Endotoxins; Es

1990
Influence of timing of administration of liposome-encapsulated superoxide dismutase on its prevention of acetaminophen-induced liver cell necrosis in rats.
    Acta pathologica japonica, 1990, Volume: 40, Issue:8

    Topics: Acetaminophen; Animals; Drug Carriers; Lipid Peroxidation; Liposomes; Liver; Male; Necrosis; Rats; R

1990
Early loss of large genomic DNA in vivo with accumulation of Ca2+ in the nucleus during acetaminophen-induced liver injury.
    Toxicology and applied pharmacology, 1990, Volume: 106, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Animals; Calcium; Cell Nucleus; Cell Survival; Chemical and Dru

1990
Acetaminophen hepatotoxicity: is there a role for prostaglandin synthesis?
    Archives of toxicology, 1990, Volume: 64, Issue:4

    Topics: Acetaminophen; Animals; Aspirin; Chemical and Drug Induced Liver Injury; Glutathione; Hexobarbital;

1990
Hepatoprotective effects of cystathionine against acetaminophen-induced necrosis.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:2

    Topics: Acetaminophen; Alkynes; Animals; Cystathionine; Glutathione; Glycine; Liver; Male; Necrosis; Pargyli

1989
Comparative study on the toxicity of acetaminophen and mercuric chloride in normal and athymic mice and rats.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1989, Volume: 13

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Female; Kidney Cortex; Male; Mercuri

1989
[Drugs cytoprotective of the gastric mucosa against ethanol damage].
    Revista espanola de las enfermedades del aparato digestivo, 1988, Volume: 73, Issue:3

    Topics: Acetaminophen; Aluminum Hydroxide; Animals; Bicarbonates; Drug Evaluation, Preclinical; Enprostil; E

1988
Effect of hyperoxia on liver necrosis induced by hepatotoxins.
    Virchows Archiv. B, Cell pathology including molecular pathology, 1986, Volume: 51, Issue:6

    Topics: Acetaminophen; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cric

1986
Nyquil-associated liver injury.
    The American journal of gastroenterology, 1989, Volume: 84, Issue:4

    Topics: Acetaminophen; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Dextromethorphan; Doxylami

1989
Development of paracetamol induced hepatocellular tolerance in albino rats.
    The Indian journal of medical research, 1988, Volume: 88

    Topics: Acetaminophen; Animals; Carbon Tetrachloride; Drug Tolerance; Liver; Necrosis; Rats; Rats, Inbred St

1988
Long-term sequellae of acetaminophen-associated fulminant hepatic failure: relevance of early histology.
    The American journal of gastroenterology, 1988, Volume: 83, Issue:5

    Topics: Acetaminophen; Acute Disease; Chemical and Drug Induced Liver Injury; Female; Follow-Up Studies; Hep

1988
Protection by dimethylsulfoxide against acetaminophen-induced hepatic, but not respiratory toxicity in the mouse.
    Toxicology and applied pharmacology, 1988, Volume: 93, Issue:3

    Topics: Acetaminophen; Animals; Carbon Tetrachloride; Dimethyl Sulfoxide; Female; Free Radicals; Glutathione

1988
Neutrophilic eccrine hidradenitis in the absence of an underlying malignancy.
    Cutis, 1988, Volume: 41, Issue:6

    Topics: Acetaminophen; Eccrine Glands; Epithelium; Humans; Inflammation; Male; Middle Aged; Necrosis; Neutro

1988
Severe liver damage caused by therapeutic doses of acetaminophen.
    Acta medica Scandinavica, 1987, Volume: 222, Issue:3

    Topics: Acetaminophen; Alanine Transaminase; Alcohol Drinking; Aspartate Aminotransferases; Chemical and Dru

1987
Extrahepatic lesions induced by acetaminophen in the mouse.
    Toxicologic pathology, 1987, Volume: 15, Issue:4

    Topics: Acetaminophen; Animals; Kidney; Lung; Lymphoid Tissue; Male; Mice; Necrosis; Testis

1987
Ultrastructural changes during acute acetaminophen-induced hepatotoxicity in the mouse: a time and dose study.
    Toxicologic pathology, 1987, Volume: 15, Issue:4

    Topics: Acetaminophen; Animals; Dose-Response Relationship, Drug; Liver; Male; Mice; Mitochondria, Liver; Ne

1987
Maternal acetaminophen overdose at 15 weeks of gestation.
    Obstetrics and gynecology, 1986, Volume: 67, Issue:5

    Topics: Acetaminophen; Acetylcysteine; Adult; Female; Fetus; Humans; Liver; Necrosis; Pregnancy; Pregnancy C

1986
[Severe liver damage following therapeutic dose of paracetamol].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1987, Apr-30, Volume: 107, Issue:12

    Topics: Acetaminophen; Adolescent; Adult; Alcohol Drinking; Chemical and Drug Induced Liver Injury; Drug Syn

1987
[Severe liver damage following suicidal intake of paracetamol].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1987, Apr-30, Volume: 107, Issue:12

    Topics: Acetaminophen; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Mal

1987
Paracetamol, 3-monoalkyl- and 3,5-dialkyl derivatives: comparison of their hepatotoxicity in mice.
    Toxicology and applied pharmacology, 1987, Jun-30, Volume: 89, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Liver; Male; Mice; Necros

1987
Time development of distribution and toxicity following single toxic APAP doses in male BOM:NMRI mice.
    Journal of applied toxicology : JAT, 1987, Volume: 7, Issue:1

    Topics: Acetaminophen; Animals; Autoradiography; Body Weight; Chemical and Drug Induced Liver Injury; Glutat

1987
Lack of cytoprotection by acetaminophen against ethanol-, HCl.ethanol- and HCl.aspirin-induced gastric mucosal lesions in rats.
    Japanese journal of pharmacology, 1987, Volume: 43, Issue:4

    Topics: 16,16-Dimethylprostaglandin E2; Acetaminophen; Animals; Aspirin; Ethanol; Gastric Mucosa; Hydrochlor

1987
Alcohol, acetaminophen, and hepatic necrosis.
    Annals of internal medicine, 1986, Volume: 105, Issue:1

    Topics: Acetaminophen; Adult; Alcoholism; Humans; Liver Diseases; Male; Necrosis

1986
Anomalous susceptibility of the fasted hamster to acetaminophen hepatotoxicity.
    Biochemical pharmacology, 1986, Mar-01, Volume: 35, Issue:5

    Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Criceti

1986
[Paracetamol poisoning with fatal necrosis of the liver].
    Ugeskrift for laeger, 1986, Oct-13, Volume: 148, Issue:42

    Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Female; Humans; Kidney Tubular Necrosis, Acut

1986
Mechanisms of fasting-induced potentiation of acetaminophen hepatotoxicity in the rat.
    Biochemical pharmacology, 1987, Feb-15, Volume: 36, Issue:4

    Topics: Acetaminophen; Animals; Drug Synergism; Fasting; Glucuronates; Glutathione; Half-Life; Kinetics; Liv

1987
Lethal enhancement of therapeutic doses of acetaminophen by alcohol.
    Digestive diseases and sciences, 1986, Volume: 31, Issue:1

    Topics: Acetaminophen; Autopsy; Bacterial Infections; Chemical and Drug Induced Liver Injury; Drug Synergism

1986
Effects of calcium channel blocking agents on calcium and centrilobular necrosis in the liver of rats treated with hepatotoxic agents.
    Biochemical pharmacology, 1986, Feb-15, Volume: 35, Issue:4

    Topics: Acetaminophen; Animals; Calcium; Calcium Channel Blockers; Carbon Tetrachloride; Chemical and Drug I

1986
Acetaminophen hepatotoxicity: studies on the mechanism of cysteamine protection.
    Toxicology and applied pharmacology, 1986, Mar-30, Volume: 83, Issue:1

    Topics: Acetaminophen; Animals; Cricetinae; Cysteamine; In Vitro Techniques; Inactivation, Metabolic; Kineti

1986
Increased hepatotoxicity of acetaminophen by concomitant administration of caffeine in the rat.
    Toxicology, 1985, Volume: 34, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Caffeine; Chemical and Dr

1985
Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in mice.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 232, Issue:3

    Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alanine Transaminase; Animals; Chemical and Dru

1985
Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat.
    Pharmacology, 1985, Volume: 30, Issue:2

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid

1985
Acetaminophen liver injury: sequential changes in two biochemical indices of regeneration and their relationship to histologic alterations.
    The Journal of laboratory and clinical medicine, 1985, Volume: 105, Issue:5

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver; Liver Regeneration; Male; Nec

1985
Additive protection of cimetidine and N-acetylcysteine treatment against acetaminophen-induced hepatic necrosis in the rat.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 234, Issue:3

    Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Cimetidine; Dose-Response Relationship, Drug;

1985
Effects of ethanol ingestion on the hepatotoxicity and metabolism of paracetamol in mice.
    Toxicology, 1985, Volume: 36, Issue:4

    Topics: Acetaminophen; Alcohol Drinking; Alcoholism; Animals; Chemical and Drug Induced Liver Injury; Cytoch

1985
Effect of hepatic failure toxins on liver thymidine kinase activity and ornithine decarboxylase activity after massive necrosis with acetaminophen in the rat.
    The Journal of laboratory and clinical medicine, 1985, Volume: 106, Issue:5

    Topics: Acetaminophen; Animals; Caprylates; Chemical and Drug Induced Liver Injury; Disulfides; Hepatectomy;

1985
Acetaminophen hepatotoxicity in vivo is not accompanied by oxidant stress.
    Biochemical and biophysical research communications, 1985, Nov-27, Volume: 133, Issue:1

    Topics: Acetaminophen; Animals; Bile; Glutathione; Liver; Male; Necrosis; Oxidation-Reduction; Rats; Rats, I

1985
Letter: Treatment of acute paracetamol hepatotoxicity.
    Lancet (London, England), 1973, Dec-15, Volume: 2, Issue:7842

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver; Liver Circulation; Microscopy

1973
Letter: Paracetamol toxicity and propranolol.
    Lancet (London, England), 1973, Dec-29, Volume: 2, Issue:7844

    Topics: Acetaminophen; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Dogs; Drug Antago

1973
Effects of mepyramine, promethazine, and hydrocortisone on paracetamol-induced hepatic necrosis in the rat.
    Clinical toxicology, 1973, Volume: 6, Issue:1

    Topics: Acetaminophen; Animals; Benzyl Compounds; Chemical and Drug Induced Liver Injury; Ethylenediamines;

1973
Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.
    The Journal of pharmacology and experimental therapeutics, 1973, Volume: 187, Issue:1

    Topics: Acetaminophen; Animals; Caffeine; Carbon Monoxide; Carbon Radioisotopes; Chemical and Drug Induced L

1973
Treatment of acute paracetamol poisoning.
    Lancet (London, England), 1968, Oct-19, Volume: 2, Issue:7573

    Topics: Acetaminophen; Adult; Blood Protein Disorders; Brain Edema; Chemical and Drug Induced Liver Injury;

1968
Commentary. A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. I. Correlation of changes in covalent binding of reactivity metabolites with changes in the incidence and severity of toxicity.
    Biochemical pharmacology, 1974, Oct-15, Volume: 23, Issue:20

    Topics: Acetaminophen; Animals; Autoradiography; Benzene Derivatives; Carbon Tetrachloride Poisoning; Carcin

1974
A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. II. Alterations in the kinetics of covalent binding.
    Biochemical pharmacology, 1974, Nov-01, Volume: 23, Issue:21

    Topics: Acetaminophen; Animals; Benzene Derivatives; Chemical Phenomena; Chemistry; Cricetinae; Diffusion; E

1974
Abnormal drug metabolism after barbiturate and paracetamol overdose.
    British medical journal, 1974, Nov-30, Volume: 4, Issue:5943

    Topics: Acetaminophen; Adult; Aged; Alanine Transaminase; Amobarbital; Antipyrine; Barbiturates; Bilirubin;

1974
Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters.
    Pharmacology, 1974, Volume: 12, Issue:3

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cricetinae; Depression, Chemical; Gl

1974
Paracetamol overdose: a plan of management.
    Anaesthesia and intensive care, 1974, Volume: 2, Issue:4

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Cardiomyopathies; Chemical and Drug Induced Liver Injury;

1974
Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen.
    Pharmacology, 1974, Volume: 12, Issue:4-5

    Topics: Acetaminophen; Acetylcysteine; Animals; Cricetinae; Depression, Chemical; Glutathione; Liver; Mass S

1974
[Liver damage following paracetamole poisoning].
    Der Internist, 1972, Volume: 13, Issue:10

    Topics: Acetaminophen; Acute Kidney Injury; Animals; Autopsy; Blood Sedimentation; Chemical and Drug Induced

1972
Protection of rats against the hepatotoxic effect of paracetamol.
    British journal of experimental pathology, 1974, Volume: 55, Issue:6

    Topics: Acetaminophen; Administration, Oral; Animals; Cysteamine; Cytochrome P-450 Enzyme System; Drug Inter

1974
Gross paracetamol overdosage with recovery.
    The Practitioner, 1973, Volume: 210, Issue:257

    Topics: Acetaminophen; Adult; Bilirubin; Chemical and Drug Induced Liver Injury; Humans; Male; Necrosis; Pre

1973
Potentiation by previous drug therapy of hepatotoxicity following paracetamol overdosage.
    Scottish medical journal, 1973, Volume: 18, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Amobarbital; Aspartate Aminotransferases; Bilirubin; Chemical and

1973
Acute acetaminophen poisoning.
    Clinical toxicology, 1973, Volume: 6, Issue:1

    Topics: Acetaminophen; Bilirubin; Blood Coagulation Disorders; Cardiomyopathies; Diuresis; Humans; Hypoglyce

1973
Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism.
    The Journal of pharmacology and experimental therapeutics, 1973, Volume: 187, Issue:1

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cobalt; Dose-Response Relationship,

1973
Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo.
    The Journal of pharmacology and experimental therapeutics, 1973, Volume: 187, Issue:1

    Topics: Acetaminophen; Animals; Carbon Radioisotopes; Cell Nucleus; Chemical and Drug Induced Liver Injury;

1973
Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione.
    The Journal of pharmacology and experimental therapeutics, 1973, Volume: 187, Issue:1

    Topics: Acetaminophen; Animals; Autoradiography; Chemical and Drug Induced Liver Injury; Cysteine; Glutathio

1973
Histological appearances in fulminant hepatic failure with reference to aetiology, time of survival and role of immunological processes.
    Digestion, 1973, Volume: 8, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Aged; Cell Nucleus; Chemical and Drug Induced Liver Injury; Haloth

1973
The effects of hepatic and renal damage on paracetamol metabolism and excretion following overdosage. A pharmacokinetic study.
    British journal of pharmacology, 1973, Volume: 49, Issue:4

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Alanine Transaminase; Aspartate Aminotr

1973
The effect of phenobarbitone pretreatment on paracetamol toxicity.
    Biomedicine / [publiee pour l'A.A.I.C.I.G.], 1973, Nov-20, Volume: 19, Issue:11

    Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced

1973
Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen.
    Life sciences, 1974, Jun-01, Volume: 14, Issue:11

    Topics: Acetaminophen; Animals; Binding Sites; Chemical and Drug Induced Liver Injury; Cricetinae; Glutathio

1974
Circuitry and technique of extracorporeal porcine liver perfusion for the treatment of hepatic coma.
    The British journal of surgery, 1971, Volume: 58, Issue:7

    Topics: Acetaminophen; Acute Disease; Animals; Extracorporeal Circulation; Fatty Liver; Hepatic Encephalopat

1971
Extracorporeal perfusion of pig liver in the treatment of acute liver failure.
    The British journal of surgery, 1971, Volume: 58, Issue:10

    Topics: Acetaminophen; Adult; Animals; Bilirubin; Brain; Chemical and Drug Induced Liver Injury; Electroence

1971
Acetaminophen-induced hepatic necrosis and renal failure.
    JAMA, 1971, Oct-18, Volume: 218, Issue:3

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Biopsy; Chemical and Drug Induced Liver Injury; Female; H

1971
Acute myocardial necrosis in paracetamol poisoning.
    British medical journal, 1971, Nov-13, Volume: 4, Issue:5784

    Topics: Acetaminophen; Adult; Cardiomyopathies; Female; Humans; Necrosis; Pregnancy

1971
[Paracetamol].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1971, Nov-20, Volume: 91, Issue:32

    Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Necrosis

1971
Experimental paracetamol-induced hepatic necrosis: a histopathological study.
    The Journal of pathology, 1971, Volume: 103, Issue:4

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytoplasmic Granules; Liver; Liver D

1971
Acute myocardial necrosis in paracetamol poisoning.
    British medical journal, 1971, Volume: 3, Issue:5772

    Topics: Acetaminophen; Adolescent; Female; Heart Diseases; Humans; Necrosis

1971
Liver necrosis and myocardiopathy following paracetamol overdosage.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1968, Mar-16, Volume: 42, Issue:11

    Topics: Acetaminophen; Adult; Cardiomyopathies; Chemical and Drug Induced Liver Injury; Female; Humans; Live

1968
Acute hepatic necrosis following an overdose of paracetamol.
    Gastroenterology, 1969, Volume: 56, Issue:4

    Topics: Acetaminophen; Acute Disease; Acute Kidney Injury; Adult; Bilirubin; Blood Glucose; Chemical and Dru

1969
Liver necrosis from paracetamol.
    British medical journal, 1966, Aug-27, Volume: 2, Issue:5512

    Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Male; Necrosis

1966
Acute liver necrosis following overdose of paracetamol.
    British medical journal, 1966, Aug-27, Volume: 2, Issue:5512

    Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Hypoglycemia; Male; Ne

1966
Liver necrosis from paracetamol.
    British journal of pharmacology and chemotherapy, 1966, Volume: 26, Issue:3

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Male; Necrosis; Organ Size; Phenacet

1966
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