An equilibrative nucleoside transporter 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14542]
36 kDa nucleolar protein HNP36;
Delayed-early response protein 12;
Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter;
Equilibrative NBMPR-insensitive nucleoside transporter;
Hydrophobic nucleolar protein,
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| uridine | Homo sapiens (human) | IC50 | 234.0000 | 1 | 1 |
| uridine | Homo sapiens (human) | Ki | 242.0000 | 1 | 1 |
| adenosine | Homo sapiens (human) | IC50 | 106.0000 | 1 | 1 |
| adenosine | Homo sapiens (human) | Ki | 106.0000 | 1 | 1 |
| tecadenoson | Homo sapiens (human) | IC50 | 190.0000 | 1 | 1 |
| tecadenoson | Homo sapiens (human) | Ki | 189.0000 | 1 | 1 |
This protein enables 9 target(s):
| Target | Category | Definition |
|---|---|---|
| neurotransmitter transmembrane transporter activity | molecular function | Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. [GOC:ai, ISBN:0198506732] |
| nucleoside transmembrane transporter activity | molecular function | Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. [GOC:ai] |
| nucleobase transmembrane transporter activity | molecular function | Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other. [ISBN:0198506732] |
| adenine transmembrane transporter activity | molecular function | Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other. [GOC:go_curators] |
| guanine transmembrane transporter activity | molecular function | Enables the transfer of guanine, 2-amino-6-hydroxypurine, from one side of a membrane to the other. [GOC:go_curators] |
| uracil transmembrane transporter activity | molecular function | Enables the transfer of uracil, 2,4-dioxopyrimidine, from one side of a membrane to the other. [GOC:go_curators] |
| purine nucleoside transmembrane transporter activity | molecular function | Enables the transfer of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, from one side of a membrane to the other. [GOC:ai] |
| cytidine transmembrane transporter activity | molecular function | Enables the transfer of cytidine, cytosine riboside, from one side of a membrane to the other. [GOC:go_curators] |
| uridine transmembrane transporter activity | molecular function | Enables the transfer of uridine, uracil riboside, from one side of a membrane to the other. [GOC:go_curators] |
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleolus | cellular component | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. [ISBN:0198506732] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| basolateral plasma membrane | cellular component | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
| apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| basolateral plasma membrane | cellular component | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is involved in 20 target(s):
| Target | Category | Definition |
|---|---|---|
| neurotransmitter uptake | biological process | The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. [ISBN:0123668387] |
| neurotransmitter transport | biological process | The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. [GOC:ai] |
| xenobiotic transmembrane transport | biological process | The process in which a xenobiotic, a compound foreign to the organim exposed to it, is transported across a membrane. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:ai, GOC:bf, GOC:krc] |
| nucleobase transport | biological process | The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [ISBN:0198506732] |
| adenine transport | biological process | The directed movement of adenine, 6-aminopurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators, ISBN:0198506732] |
| nucleoside transport | biological process | The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| purine nucleoside transmembrane transport | biological process | The process in which a purine nucleoside is transported across a membrane. A purine nucleoside is a purine base covalently bonded to a ribose or deoxyribose sugar. [GOC:ai, GOC:vw] |
| cytidine transport | biological process | The directed movement of cytidine, cytosine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators] |
| uridine transmembrane transport | biological process | The directed movement of uridine, uracil riboside, across a lipid bilayer, by means of some agent such as a transporter or pore. [GOC:go_curators] |
| adenosine transport | biological process | The directed movement of adenosine, adenine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah] |
| inosine transport | biological process | The directed movement of the purine ribonucleoside inosine, also known as hypoxanthine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [PMID:19135251] |
| hypoxanthine transport | biological process | The directed movement of hypoxanthine, 6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:sl] |
| thymine transport | biological process | The directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GO:sl] |
| pyrimidine-containing compound transmembrane transport | biological process | The process in which a pyrimidine-containing compound is transported across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof. [GOC:mah] |
| transport across blood-brain barrier | biological process | The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008] |
| nucleoside transmembrane transport | biological process | The directed movement of nucleoside across a membrane. [GOC:pr, GOC:TermGenie] |
| guanine transmembrane transport | biological process | The process in which guanine is transported across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:14998997] |
| uracil transmembrane transport | biological process | The process in which uracil is transported across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:8948441] |
| purine nucleobase transmembrane transport | biological process | The process in which a purine nucleobase is transported across a membrane. [GO_REF:0000069, GOC:TermGenie] |
| guanine transport | biological process | The directed movement of guanine, 2-amino-6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:go_curators] |