Page last updated: 2024-12-08

fluciclovine f-18

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Description

fluciclovine F-18: A radioactive diagnostic agent used for the detection of recurrent prostate cancer by POSITRON EMISSION TOMOGRAPHY; structure in first source. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID450601
CHEMBL ID254468
CHEMBL ID447701
CHEBI ID134703
SCHEMBL ID11939900
SCHEMBL ID11939897
SCHEMBL ID10017245
MeSH IDM0453315

Synonyms (61)

Synonym
MOLI001120 ,
anti-1-amino-3-[18f]fluorocyclobutane-1-carboxylic acid
anti-[18f]facbc
[18F]FACBC
fluciclovine (18f)
CHEBI:134703 ,
fluciclovine f-18
fluciclovine f18
facbc f-18
(18f)ge-148
CHEMBL254468
ge-148 f-18
ge-148
(18f)facbc
fluciclovine f 18
nmk36
ge-148 (18f)
facbc
nmk-36
CHEMBL447701
SYN-3-[18F]FACBC
syn-1-amino-3-[18f]fluorocyclobutane-1-carboxylic acid
SCHEMBL11939900
SCHEMBL11939897
fluciclovine (18f) [inn]
222727-39-1
f(18)1-amino-3-fluorocyclobutane-1-carboxylic acid
nmk 36
38r1q0l1ze ,
unii-38r1q0l1ze
(1r,3r)-1-amino-3(18f)fluorocyclobutane-1-carboxylic acid
axumincn facbccn fluciclovine (18f)cn ge 148cn nmk 36
(18f)fluciclovine
nmk36 cpd
cyclobutanecarboxylic acid, 1-amino-3-(fluoro-18f)-, trans-
anti-1-amino-3-(18f)fluorocyclobutane-1-carboxylic acid
fluciclovine ((sup 18)f)
anti-(18f)fabc
fluciclovine ((sup 18)f) [inn]
axumin
fluciclovine f18 [usan]
fluciclovine f-18 [orange book]
fluciclovine (18f) [who-dd]
fluciclovine (18f) [mi]
fluciclovine ((1)f) [inn]
fluciclovine f 18 [usan]
SCHEMBL10017245
fluciclovine (18f) (inn)
fluciclovine f-18 (usan)
axumin (tn)
D10860
DB13146
anti-3[18f] facbc;f18; anti-1-amino-3-18f-fluorocyclobutane-1-carboxylic acid (facbc)
BCP24384
fluciclovine-f18
Q25313613
AT31246
1-amino-3-(18f)fluoranylcyclobutane-1-carboxylic acid
DTXSID601027796
(1r,3r)-1-amino-3-(18f)fluorocyclobutane-1-carboxylic acid
EN300-7612867

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Seven of non-serious adverse events were observed in six patients."( Diagnostic performance and safety of NMK36 (trans-1-amino-3-[18F]fluorocyclobutanecarboxylic acid)-PET/CT in primary prostate cancer: multicenter Phase IIb clinical trial.
Fujimoto, H; Fukasawa, S; Inoue, T; Inoue, Y; Otaka, A; Saito, S; Suzuki, H; Tanabe, K; Ueno, M; Yonese, J, 2016
)
0.43
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (61)

Assay IDTitleYearJournalArticle
AID393469Biodistribution in testis of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 30 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393438Biodistribution in liver of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 60 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393465Biodistribution in bone of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 30 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393452Biodistribution in muscle of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 15 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393427Biodistribution in blood of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 120 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393463Biodistribution in tumor of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 120 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393451Biodistribution in kidney of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 120 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID475306Ratio of drug level in Fisher 344 rat brain to rat 9L tumor cells implanted in Fisher 344 rat after 30 mins2010Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7
Synthesis and biological evaluation of anti-1-amino-2-[18F]fluoro-cyclobutyl-1-carboxylic acid (anti-2-[18F]FACBC) in rat 9L gliosarcoma.
AID393429Biodistribution in heart of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 30 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393454Biodistribution in muscle of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 60 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393474Ratio of drug level from tumor to brain of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 60 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393450Biodistribution in kidney of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 60 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393464Biodistribution in bone of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 15 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393471Biodistribution in testis of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 120 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393468Biodistribution in testis of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 15 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393441Biodistribution in pancreas of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 30 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393472Ratio of drug level from tumor to brain of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 15 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393433Biodistribution in lung of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 30 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393449Biodistribution in kidney of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 30 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393424Biodistribution in blood of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 15 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393437Biodistribution in liver of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 30 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393440Biodistribution in pancreas of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 15 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393435Biodistribution in lung of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 120 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393460Biodistribution in tumor of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 15 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393421Drug uptake in rat 9L cells assessed as intracellular accumulation after 30 mins measured per 5 x 10'5 cells by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393443Biodistribution in pancreas of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 120 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393456Biodistribution in brain of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 15 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393430Biodistribution in heart of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 60 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393426Biodistribution in blood of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 60 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393458Biodistribution in brain of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 60 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393457Biodistribution in brain of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 30 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393448Biodistribution in kidney of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 15 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393428Biodistribution in heart of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 15 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393436Biodistribution in liver of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 15 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393475Ratio of drug level from tumor to brain of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 120 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393466Biodistribution in bone of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 60 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393467Biodistribution in bone of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 120 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393473Ratio of drug level from tumor to brain of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 30 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393446Biodistribution in spleen of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 60 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393442Biodistribution in pancreas of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 60 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393434Biodistribution in lung of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 60 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393425Biodistribution in blood of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 30 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393461Biodistribution in tumor of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 30 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393432Biodistribution in lung of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 15 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393431Biodistribution in heart of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 120 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393470Biodistribution in testis of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 60 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393445Biodistribution in spleen of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 30 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393439Biodistribution in liver of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 120 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393462Biodistribution in tumor of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 60 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393453Biodistribution in muscle of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 30 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393455Biodistribution in muscle of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 120 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393444Biodistribution in spleen of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 15 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393459Biodistribution in brain of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 120 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID393447Biodistribution in spleen of rat 9L cells implanted Fischer rat at 15 to 30 uCi, iv after 120 mins by gamma-counter2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID463483Biodistribution in tumor of Fischer 344 rat bearing rat 9L cells at 20 uCi, iv after 120 mins2010Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
Synthesis, radiolabeling, and biological evaluation of (R)- and (S)-2-amino-3-[(18)F]fluoro-2-methylpropanoic acid (FAMP) and (R)- and (S)-3-[(18)F]fluoro-2-methyl-2-N-(methylamino)propanoic acid (NMeFAMP) as potential PET radioligands for imaging brain t
AID393423Drug uptake in rat 9L cells assessed as intracellular accumulation after 30 mins measured per 5 x 10'5 cells by gamma-counter in presence of alanine-cysteine-serine2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID463482Biodistribution in tumor of Fischer 344 rat bearing rat 9L cells at 20 uCi, iv after 60 mins2010Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
Synthesis, radiolabeling, and biological evaluation of (R)- and (S)-2-amino-3-[(18)F]fluoro-2-methylpropanoic acid (FAMP) and (R)- and (S)-3-[(18)F]fluoro-2-methyl-2-N-(methylamino)propanoic acid (NMeFAMP) as potential PET radioligands for imaging brain t
AID463664Ratio of drug level from tumor to brain of Fischer 344 rat bearing rat 9L cells at 20 uCi, iv after 15 mins2010Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
Synthesis, radiolabeling, and biological evaluation of (R)- and (S)-2-amino-3-[(18)F]fluoro-2-methylpropanoic acid (FAMP) and (R)- and (S)-3-[(18)F]fluoro-2-methyl-2-N-(methylamino)propanoic acid (NMeFAMP) as potential PET radioligands for imaging brain t
AID314561Ratio of drug uptake in tumor to brain in Fischer rat transplanted with rat 9L cells2008Bioorganic & medicinal chemistry letters, Feb-15, Volume: 18, Issue:4
Synthesis and evaluation of [123I] labeled iodovinyl amino acids syn-, anti-1-amino-3-[2-iodoethenyl]-cyclobutane-1-carboxylic acid, and 1-amino-3-iodomethylene-cyclobutane-1-carboxylic acid as potential SPECT brain tumor imaging agents.
AID393422Drug uptake in rat 9L cells assessed as intracellular accumulation after 30 mins measured per 5 x 10'5 cells by gamma-counter in presence of 2-aminobicyclo[2.2.1]-heptane-2-carboxylic acid2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent.
AID314560Drug uptake in tumor cells in Fischer rat transplanted with rat 9L cells after 60 mins2008Bioorganic & medicinal chemistry letters, Feb-15, Volume: 18, Issue:4
Synthesis and evaluation of [123I] labeled iodovinyl amino acids syn-, anti-1-amino-3-[2-iodoethenyl]-cyclobutane-1-carboxylic acid, and 1-amino-3-iodomethylene-cyclobutane-1-carboxylic acid as potential SPECT brain tumor imaging agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (162)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (0.62)18.2507
2000's8 (4.94)29.6817
2010's94 (58.02)24.3611
2020's59 (36.42)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 43.21

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index43.21 (24.57)
Research Supply Index5.23 (2.92)
Research Growth Index6.16 (4.65)
Search Engine Demand Index60.89 (26.88)
Search Engine Supply Index1.94 (0.95)

This Compound (43.21)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials16 (9.47%)5.53%
Reviews23 (13.61%)6.00%
Case Studies56 (33.14%)4.05%
Observational0 (0.00%)0.25%
Other74 (43.79%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]