A eukaryotic-type peptidyl-prolyl cis-trans isomerase D that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q08752]
Discovery of novel Cyclophilin D inhibitors starting from three dimensional fragments with millimolar potencies.Bioorganic & medicinal chemistry letters, , 12-01, Volume: 29, Issue:23, 2019
Identification of a Small Molecule Cyclophilin D Inhibitor for Rescuing Aβ-Mediated Mitochondrial Dysfunction.ACS medicinal chemistry letters, , Mar-10, Volume: 7, Issue:3, 2016
Small Molecule Inhibitors of Cyclophilin D To Protect Mitochondrial Function as a Potential Treatment for Acute Pancreatitis.Journal of medicinal chemistry, , Mar-24, Volume: 59, Issue:6, 2016
Facile synthesis of a fluorescent cyclosporin a analogue to study cyclophilin 40 and cyclophilin 18 ligands.ACS medicinal chemistry letters, , Dec-09, Volume: 1, Issue:9, 2010
| Target | Category | Definition |
|---|
| peptidyl-prolyl cis-trans isomerase activity | molecular function | Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). [EC:5.2.1.8] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| transcription factor binding | molecular function | Binding to a transcription factor, a protein required to initiate or regulate transcription. [ISBN:0198506732] |
| cyclosporin A binding | molecular function | Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids. [GOC:mb] |
| nuclear estrogen receptor binding | molecular function | Binding to a nuclear estrogen receptor. [GOC:ai] |
| Hsp70 protein binding | molecular function | Binding to a Hsp70 protein, heat shock proteins around 70kDa in size. [ISBN:0198506732] |
| heat shock protein binding | molecular function | Binding to a heat shock protein, a protein synthesized or activated in response to heat shock. [GOC:mah, GOC:vw] |
| Hsp90 protein binding | molecular function | Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size. [GOC:ai] |
| Target | Category | Definition |
|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| nucleolus | cellular component | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. [ISBN:0198506732] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| Target | Category | Definition |
|---|
| negative regulation of transcription by RNA polymerase II | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH] |
| protein peptidyl-prolyl isomerization | biological process | The modification of a protein by cis-trans isomerization of a proline residue. [GOC:krc, PMID:16959570] |
| protein folding | biological process | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. [GOC:go_curators, GOC:rb] |
| apoptotic process | biological process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] |
| protein transport | biological process | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| viral release from host cell | biological process | The dissemination of mature viral particles from a host cell, e.g. by cell lysis or the budding of virus particles from the cell membrane. [GOC:jl] |
| lipid droplet organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle. [GOC:dph, GOC:jl, GOC:mah, PMID:18093937, PMID:18250201] |
| positive regulation of apoptotic process | biological process | Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis] |
| positive regulation of viral genome replication | biological process | Any process that activates or increases the frequency, rate or extent of viral genome replication. [GOC:ai] |
| positive regulation of protein secretion | biological process | Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. [GOC:ai] |
| chaperone-mediated protein folding | biological process | The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone. [GOC:dph, GOC:vw] |
| protein-containing complex assembly | biological process | The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. [GOC:jl] |
| cellular response to UV-A | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm. [GOC:mah] |