Page last updated: 2024-12-08

3-(cystein-s-yl)paracetamol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID171264
CHEMBL ID3785905
CHEBI ID180558
SCHEMBL ID3454308
MeSH IDM0175144

Synonyms (23)

Synonym
CHEBI:180558
3-cysteinylacetaminophen
53446-10-9
(2r)-3-(5-acetamido-2-hydroxyphenyl)sulanyl-2-aminopropanoic acid
3-(cystein-s-yl)paracetamol
(2r)-3-(5-acetamido-2-hydroxyphenyl)sulfanyl-2-aminopropanoic acid
6q2x58y8bp ,
l-cysteine, s-(5-(acetylamino)-2-hydroxyphenyl)-
unii-6q2x58y8bp
paracetamol-cysteine
SCHEMBL3454308
3-(cystein-s-yl)acetaminophen (*)
(2r)-3-[(5-acetamido-2-hydroxy-phenyl)thio]-2-amino-propionic acid
3-cysteinylacetaminophen-d3
DTXSID70201608
CHEMBL3785905
(r)-3-(5-acetamido-2-hydroxyphenylthio)-2-aminopropanoic acid
3-(cysteine-s-yl)-paracetamol
(r)-3-((5-acetamido-2-hydroxyphenyl)thio)-2-aminopropanoic acid
Q27265314
3-cysteinylacetaminophen, trifluoroacetic acid salt
PD070518
(r)-3-((5-acetamido-2-hydroxyphenyl)thio)-2-aminopropanoicacid

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" A sigmoid Emax model was used as the pharmacodynamic model."( Pharmacokinetics/pharmacodynamics of acetaminophen analgesia in Japanese patients with chronic pain.
Aoyama, T; Aoyama, Y; Matsumoto, Y; Ohe, Y; Shinoda, S; Tomioka, S, 2007
)
0.34
" The following study examined the pharmacokinetic profile and clinical associations of adducts in 53 adults with acute APAP overdose resulting in acute liver failure."( Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
Capparelli, E; Davern, TJ; Hinson, JA; James, LP; Lee, WM; Letzig, L; Roberts, DW; Simpson, PM, 2009
)
0.35

Dosage Studied

ExcerptRelevanceReference
" These results suggest that these parameters can be used to determine an effective APAP dosage regimen for Japanese patients with chronic pain."( Pharmacokinetics/pharmacodynamics of acetaminophen analgesia in Japanese patients with chronic pain.
Aoyama, T; Aoyama, Y; Matsumoto, Y; Ohe, Y; Shinoda, S; Tomioka, S, 2007
)
0.34
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
S-conjugateA bioconjugate containing molecules covalently bonded by a sulphur linkage
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1289079Drug level in Japanese healthy volunteer treated with acetaminophen at 1000 mg, po by HPLC method2007Biological & pharmaceutical bulletin, Jan, Volume: 30, Issue:1
Pharmacokinetics/pharmacodynamics of acetaminophen analgesia in Japanese patients with chronic pain.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's4 (57.14)18.2507
2000's2 (28.57)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.97

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.97 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.27 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.97)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (12.50%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (87.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]