Page last updated: 2024-08-07 15:42:51
Macrophage colony-stimulating factor 1 receptor
A macrophage colony-stimulating factor 1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P07333]
Synonyms
CSF-1 receptor;
CSF-1-R;
CSF-1R;
M-CSF-R;
2.7.10.1;
Proto-oncogene c-Fms
Research
Bioassay Publications (80)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 25 (31.25) | 29.6817 |
| 2010's | 38 (47.50) | 24.3611 |
| 2020's | 17 (21.25) | 2.80 |
Compounds (109)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| imatinib | Homo sapiens (human) | GI50 | 0.1100 | 1 | 1 |
| imatinib | Homo sapiens (human) | IC50 | 0.8417 | 3 | 3 |
| staurosporine | Homo sapiens (human) | IC50 | 0.1269 | 7 | 9 |
| lestaurtinib | Homo sapiens (human) | IC50 | 0.0310 | 1 | 1 |
| ptk 787 | Homo sapiens (human) | IC50 | 1.2400 | 1 | 1 |
| birb 796 | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| sorafenib | Homo sapiens (human) | IC50 | 0.0385 | 2 | 2 |
| s 1033 | Homo sapiens (human) | IC50 | 0.6770 | 1 | 1 |
| ag-213 | Homo sapiens (human) | IC50 | 3.0667 | 1 | 3 |
| N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-1-naphthalenecarboxamide | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| tandutinib | Homo sapiens (human) | IC50 | 3.4300 | 1 | 1 |
| dasatinib | Homo sapiens (human) | IC50 | 0.0078 | 4 | 4 |
| dasatinib | Homo sapiens (human) | Ki | 0.0100 | 1 | 1 |
| zd 6474 | Homo sapiens (human) | IC50 | 1.6000 | 1 | 1 |
| gtp 14564 | Homo sapiens (human) | IC50 | 0.3000 | 1 | 1 |
| semaxinib | Homo sapiens (human) | IC50 | 0.0840 | 1 | 1 |
| su 11248 | Homo sapiens (human) | IC50 | 0.0888 | 4 | 4 |
| palbociclib | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| 2-((4-pyridyl)methyl)amino-n-(3-(trifluoromethyl)phenyl)benzamide | Homo sapiens (human) | IC50 | 0.3800 | 1 | 1 |
| su 4312 | Homo sapiens (human) | IC50 | 4.4000 | 1 | 3 |
| su 11248 | Homo sapiens (human) | IC50 | 0.0120 | 1 | 1 |
| gdp 366 | Homo sapiens (human) | IC50 | 0.0030 | 1 | 1 |
| gw843682x | Homo sapiens (human) | IC50 | 0.6200 | 1 | 1 |
| midostaurin | Homo sapiens (human) | IC50 | 0.1420 | 1 | 1 |
| ki 20227 | Homo sapiens (human) | IC50 | 0.0300 | 1 | 1 |
| ct52923 | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| pazopanib | Homo sapiens (human) | IC50 | 0.2100 | 2 | 2 |
| abt 869 | Homo sapiens (human) | IC50 | 0.0321 | 3 | 8 |
| azd2932 | Homo sapiens (human) | IC50 | 0.1000 | 2 | 2 |
| plx647 | Homo sapiens (human) | IC50 | 0.0280 | 1 | 1 |
| gw 2580 | Homo sapiens (human) | IC50 | 0.1947 | 13 | 11 |
| crizotinib | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| 4-cyano-N-[4-(4-methyl-1-piperazinyl)-2-(4-methyl-1-piperidinyl)phenyl]-1H-pyrrole-2-carboxamide | Homo sapiens (human) | IC50 | 0.0008 | 4 | 4 |
| jnj 28312141 | Homo sapiens (human) | IC50 | 0.0007 | 2 | 2 |
| nvp-tae684 | Homo sapiens (human) | IC50 | 0.0501 | 1 | 1 |
| enmd 2076 | Homo sapiens (human) | IC50 | 0.3050 | 2 | 2 |
| plx 4720 | Homo sapiens (human) | IC50 | 1.8466 | 1 | 8 |
| amg 458 | Homo sapiens (human) | IC50 | 0.2380 | 1 | 1 |
| tak 593 | Homo sapiens (human) | IC50 | 0.0100 | 1 | 1 |
| pci 32765 | Homo sapiens (human) | IC50 | 3.2725 | 2 | 2 |
| ponatinib | Homo sapiens (human) | IC50 | 0.0086 | 1 | 1 |
| N-cyclopropyl-3-{4-[(cyclopropylmethyl)carbamoyl]phenyl}-4-methylbenzamide | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| pexidartinib | Homo sapiens (human) | IC50 | 0.0136 | 13 | 13 |
| jnj-40346527 | Homo sapiens (human) | IC50 | 0.0032 | 2 | 2 |
| blz 945 | Homo sapiens (human) | IC50 | 0.0524 | 3 | 3 |
| abt-348 | Homo sapiens (human) | IC50 | 0.0160 | 1 | 1 |
| abt-348 | Homo sapiens (human) | Ki | 0.0032 | 1 | 1 |
| glpg0634 | Homo sapiens (human) | IC50 | 0.4890 | 2 | 1 |
| on123300 | Homo sapiens (human) | IC50 | 0.0100 | 1 | 1 |
| cc214-2 | Homo sapiens (human) | IC50 | 2.7000 | 1 | 1 |
| cc-223 | Homo sapiens (human) | IC50 | 0.0280 | 1 | 1 |
| cc-115 | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| pf-543 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| chir 258 | Homo sapiens (human) | IC50 | 0.0020 | 2 | 2 |
| pf-477736 | Homo sapiens (human) | IC50 | 0.0100 | 1 | 0 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| sb 202190 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| imatinib | Homo sapiens (human) | Kd | 0.0133 | 3 | 3 |
| staurosporine | Homo sapiens (human) | Kd | 0.0120 | 2 | 2 |
| gefitinib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| lestaurtinib | Homo sapiens (human) | Kd | 0.1100 | 2 | 2 |
| vatalanib | Homo sapiens (human) | Kd | 0.0315 | 2 | 2 |
| ruboxistaurin | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| canertinib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| birb 796 | Homo sapiens (human) | Kd | 8.1000 | 2 | 2 |
| cyc 202 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| sb 203580 | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| enzastaurin | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| erlotinib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| lapatinib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| sorafenib | Homo sapiens (human) | Kd | 0.0280 | 4 | 4 |
| pd 173955 | Homo sapiens (human) | Kd | 0.0007 | 1 | 1 |
| s 1033 | Homo sapiens (human) | Kd | 0.0450 | 1 | 1 |
| bms 387032 | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| tandutinib | Homo sapiens (human) | Kd | 0.0049 | 3 | 3 |
| vx-745 | Homo sapiens (human) | Kd | 2.6000 | 2 | 2 |
| dasatinib | Homo sapiens (human) | Kd | 0.0006 | 3 | 3 |
| zd 6474 | Homo sapiens (human) | Kd | 1.2000 | 2 | 2 |
| 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| alvocidib | Homo sapiens (human) | Kd | 2.8000 | 2 | 2 |
| bosutinib | Homo sapiens (human) | Kd | 0.3800 | 1 | 1 |
| su 11248 | Homo sapiens (human) | Kd | 0.0022 | 3 | 3 |
| jnj-7706621 | Homo sapiens (human) | Kd | 4.2000 | 1 | 1 |
| vx680 | Homo sapiens (human) | Kd | 1.8000 | 2 | 2 |
| ekb 569 | Homo sapiens (human) | Kd | 4.3000 | 1 | 1 |
| axitinib | Homo sapiens (human) | Kd | 0.0210 | 1 | 1 |
| pd 184352 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| bms345541 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| midostaurin | Homo sapiens (human) | Kd | 0.3300 | 3 | 3 |
| ki 20227 | Homo sapiens (human) | Kd | 0.0008 | 1 | 1 |
| cp 724714 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| pi103 | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| hki 272 | Homo sapiens (human) | Kd | 0.6700 | 1 | 1 |
| tofacitinib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamide | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| cediranib | Homo sapiens (human) | Kd | 0.0130 | 1 | 1 |
| masitinib | Homo sapiens (human) | Kd | 0.0076 | 1 | 1 |
| pazopanib | Homo sapiens (human) | Kd | 0.0079 | 2 | 2 |
| azd 6244 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| su 14813 | Homo sapiens (human) | Kd | 0.0036 | 2 | 2 |
| bibw 2992 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| tg100-115 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| pha 665752 | Homo sapiens (human) | Kd | 0.7000 | 1 | 1 |
| 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one | Homo sapiens (human) | Kd | 0.0310 | 1 | 1 |
| brivanib | Homo sapiens (human) | Kd | 1.9000 | 1 | 1 |
| at 7519 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| bi 2536 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| nvp-ast487 | Homo sapiens (human) | Kd | 0.0058 | 2 | 2 |
| kw 2449 | Homo sapiens (human) | Kd | 0.1200 | 1 | 1 |
| abt 869 | Homo sapiens (human) | Kd | 0.0034 | 2 | 2 |
| gw 2580 | Homo sapiens (human) | Kd | 0.0019 | 2 | 2 |
| crizotinib | Homo sapiens (human) | Kd | 0.2100 | 1 | 1 |
| chir-265 | Homo sapiens (human) | Kd | 0.2500 | 2 | 2 |
| motesanib | Homo sapiens (human) | Kd | 0.0056 | 2 | 2 |
| mln8054 | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| GDC-0879 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| gsk 461364 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| azd 1152-hqpa | Homo sapiens (human) | Kd | 1.4000 | 2 | 2 |
| nvp-tae684 | Homo sapiens (human) | Kd | 0.0480 | 1 | 1 |
| fedratinib | Homo sapiens (human) | Kd | 0.6200 | 1 | 1 |
| gsk690693 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| gdc 0941 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| plx 4720 | Homo sapiens (human) | Kd | 2.7000 | 1 | 1 |
| sgx 523 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| quizartinib | Homo sapiens (human) | Kd | 0.0104 | 6 | 6 |
| incb-018424 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| gsk 1838705a | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| gsk 1363089 | Homo sapiens (human) | Kd | 0.0018 | 1 | 1 |
| blz 945 | Homo sapiens (human) | Kd | 0.0034 | 1 | 1 |
| cep-32496 | Homo sapiens (human) | Kd | 0.0090 | 1 | 1 |
| chir 258 | Homo sapiens (human) | Kd | 0.0600 | 2 | 2 |
| nintedanib | Homo sapiens (human) | Kd | 0.0480 | 1 | 1 |
| pp242 | Homo sapiens (human) | Kd | 3.3000 | 1 | 1 |
Enables
This protein enables 8 target(s):
| Target | Category | Definition |
|---|---|---|
| protein tyrosine kinase activity | molecular function | Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. [RHEA:10596] |
| macrophage colony-stimulating factor receptor activity | molecular function | Combining with macrophage colony-stimulating factor (M-CSF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. [GOC:mah, GOC:signaling] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| protein phosphatase binding | molecular function | Binding to a protein phosphatase. [GOC:jl] |
| cytokine binding | molecular function | Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. [GOC:ai, GOC:bf, ISBN:0198599471] |
| protein homodimerization activity | molecular function | Binding to an identical protein to form a homodimer. [GOC:jl] |
| growth factor binding | molecular function | Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. [GOC:curators] |
Located In
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| cell surface | cellular component | The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm] |
| intracellular membrane-bounded organelle | cellular component | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Part Of
This protein is part of 2 target(s):
| Target | Category | Definition |
|---|---|---|
| CSF1-CSF1R complex | cellular component | A protein complex consisting of a macrophage colony-stimulating factor (CSF1, also called M-CSF) dimer bound to a dimerized receptor (CSF1R, also called FMS). Receptor dimerization requires the presence of the ligand. [GOC:bf, GOC:BHF, GOC:nc, PMID:19017797] |
| receptor complex | cellular component | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:go_curators] |
Involved In
This protein is involved in 42 target(s):
| Target | Category | Definition |
|---|---|---|
| positive regulation of protein phosphorylation | biological process | Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. [GOC:hjd] |
| response to ischemia | biological process | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply. [GOC:hjd] |
| inflammatory response | biological process | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732] |
| signal transduction | biological process | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11] |
| cell surface receptor protein tyrosine kinase signaling pathway | biological process | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb, GOC:signaling] |
| axon guidance | biological process | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. [ISBN:0878932437] |
| cell population proliferation | biological process | The multiplication or reproduction of cells, resulting in the expansion of a cell population. [GOC:mah, GOC:mb] |
| positive regulation of cell population proliferation | biological process | Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators] |
| negative regulation of cell population proliferation | biological process | Any process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators] |
| regulation of cell shape | biological process | Any process that modulates the surface configuration of a cell. [GOC:dph, GOC:go_curators, GOC:tb] |
| peptidyl-tyrosine phosphorylation | biological process | The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. [RESID:AA0039] |
| cytokine-mediated signaling pathway | biological process | The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling, PMID:19295629] |
| olfactory bulb development | biological process | The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] |
| forebrain neuron differentiation | biological process | The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] |
| hemopoiesis | biological process | The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. [GOC:dgh, ISBN:0198506732] |
| monocyte differentiation | biological process | The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. [GOC:mah] |
| macrophage differentiation | biological process | The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage. [GOC:add, ISBN:0781735149] |
| osteoclast differentiation | biological process | The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. [CL:0000092, GOC:add, ISBN:0781735149, PMID:12161749] |
| ruffle organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell. [GOC:mah, PMID:10036235] |
| positive regulation of chemokine production | biological process | Any process that activates or increases the frequency, rate, or extent of chemokine production. [GOC:mah] |
| regulation of actin cytoskeleton organization | biological process | Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. [GOC:mah] |
| cellular response to macrophage colony-stimulating factor stimulus | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus. [GOC:yaf, PMID:14687666] |
| macrophage colony-stimulating factor signaling pathway | biological process | The series of molecular signals initiated by the binding of the cytokine macrophage colony-stimulating factor (M-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, GOC:uh, PMID:12138890, Wikipedia:Macrophage_colony-stimulating_factor] |
| positive regulation of tyrosine phosphorylation of STAT protein | biological process | Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. [GOC:jl, PMID:11426647] |
| negative regulation of apoptotic process | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis] |
| positive regulation by host of viral process | biological process | A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected. [GOC:jl] |
| innate immune response | biological process | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu] |
| regulation of bone resorption | biological process | Any process that modulates the frequency, rate or extent of bone tissue loss (resorption). [GOC:ai] |
| cell-cell junction maintenance | biological process | The maintenance of junctions between cells. [GOC:ai] |
| protein autophosphorylation | biological process | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). [ISBN:0198506732] |
| positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | biological process | Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai] |
| mammary gland duct morphogenesis | biological process | The process in which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk. [GOC:dph, PMID:17120154] |
| positive regulation of protein tyrosine kinase activity | biological process | Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity. [GOC:dph, GOC:tb] |
| microglial cell proliferation | biological process | The expansion of a microglial cell population by cell division. [GOC:dph, PMID:17344397] |
| positive regulation of ERK1 and ERK2 cascade | biological process | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah] |
| cellular response to cytokine stimulus | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. [GOC:mah] |
| regulation of macrophage migration | biological process | Any process that modulates the frequency, rate or extent of macrophage migration. [GO_REF:0000058, GOC:TermGenie, PMID:25749876] |
| positive regulation of cell motility | biological process | Any process that activates or increases the frequency, rate or extent of cell motility. [GOC:mah] |
| positive regulation of cell migration | biological process | Any process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators] |
| regulation of MAPK cascade | biological process | Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade. [GOC:go_curators] |
| positive regulation of kinase activity | biological process | Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:mah] |
| multicellular organism development | biological process | The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] |