Proteins > Macrophage colony-stimulating factor 1 receptor
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Macrophage colony-stimulating factor 1 receptor

A macrophage colony-stimulating factor 1 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P07333]

Synonyms

CSF-1 receptor;
CSF-1-R;
CSF-1R;
M-CSF-R;
2.7.10.1;
Proto-oncogene c-Fms

Research

Bioassay Publications (80)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's25 (31.25)29.6817
2010's38 (47.50)24.3611
2020's17 (21.25)2.80

Compounds (109)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
imatinibHomo sapiens (human)GI500.110011
imatinibHomo sapiens (human)IC500.841733
staurosporineHomo sapiens (human)IC500.126979
lestaurtinibHomo sapiens (human)IC500.031011
ptk 787Homo sapiens (human)IC501.240011
birb 796Homo sapiens (human)IC5030.000011
sorafenibHomo sapiens (human)IC500.038522
s 1033Homo sapiens (human)IC500.677011
ag-213Homo sapiens (human)IC503.066713
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-1-naphthalenecarboxamideHomo sapiens (human)IC5010.000011
tandutinibHomo sapiens (human)IC503.430011
dasatinibHomo sapiens (human)IC500.007844
dasatinibHomo sapiens (human)Ki0.010011
zd 6474Homo sapiens (human)IC501.600011
gtp 14564Homo sapiens (human)IC500.300011
semaxinibHomo sapiens (human)IC500.084011
su 11248Homo sapiens (human)IC500.088844
palbociclibHomo sapiens (human)IC5010.000011
2-((4-pyridyl)methyl)amino-n-(3-(trifluoromethyl)phenyl)benzamideHomo sapiens (human)IC500.380011
su 4312Homo sapiens (human)IC504.400013
su 11248Homo sapiens (human)IC500.012011
gdp 366Homo sapiens (human)IC500.003011
gw843682xHomo sapiens (human)IC500.620011
midostaurinHomo sapiens (human)IC500.142011
ki 20227Homo sapiens (human)IC500.030011
ct52923Homo sapiens (human)IC5030.000011
pazopanibHomo sapiens (human)IC500.210022
abt 869Homo sapiens (human)IC500.032138
azd2932Homo sapiens (human)IC500.100022
plx647Homo sapiens (human)IC500.028011
gw 2580Homo sapiens (human)IC500.19471311
crizotinibHomo sapiens (human)IC5010.000011
4-cyano-N-[4-(4-methyl-1-piperazinyl)-2-(4-methyl-1-piperidinyl)phenyl]-1H-pyrrole-2-carboxamideHomo sapiens (human)IC500.000844
jnj 28312141Homo sapiens (human)IC500.000722
nvp-tae684Homo sapiens (human)IC500.050111
enmd 2076Homo sapiens (human)IC500.305022
plx 4720Homo sapiens (human)IC501.846618
amg 458Homo sapiens (human)IC500.238011
tak 593Homo sapiens (human)IC500.010011
pci 32765Homo sapiens (human)IC503.272522
ponatinibHomo sapiens (human)IC500.008611
N-cyclopropyl-3-{4-[(cyclopropylmethyl)carbamoyl]phenyl}-4-methylbenzamideHomo sapiens (human)IC5020.000011
pexidartinibHomo sapiens (human)IC500.01361313
jnj-40346527Homo sapiens (human)IC500.003222
blz 945Homo sapiens (human)IC500.052433
abt-348Homo sapiens (human)IC500.016011
abt-348Homo sapiens (human)Ki0.003211
glpg0634Homo sapiens (human)IC500.489021
on123300Homo sapiens (human)IC500.010011
cc214-2Homo sapiens (human)IC502.700011
cc-223Homo sapiens (human)IC500.028011
cc-115Homo sapiens (human)IC502.000011
pf-543Homo sapiens (human)IC5010.000011
chir 258Homo sapiens (human)IC500.002022
pf-477736Homo sapiens (human)IC500.010010

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
sb 202190Homo sapiens (human)Kd10.000011
imatinibHomo sapiens (human)Kd0.013333
staurosporineHomo sapiens (human)Kd0.012022
gefitinibHomo sapiens (human)Kd10.000022
lestaurtinibHomo sapiens (human)Kd0.110022
vatalanibHomo sapiens (human)Kd0.031522
ruboxistaurinHomo sapiens (human)Kd10.000022
canertinibHomo sapiens (human)Kd10.000022
birb 796Homo sapiens (human)Kd8.100022
cyc 202Homo sapiens (human)Kd10.000011
sb 203580Homo sapiens (human)Kd10.000022
enzastaurinHomo sapiens (human)Kd10.000011
erlotinibHomo sapiens (human)Kd10.000022
lapatinibHomo sapiens (human)Kd10.000022
sorafenibHomo sapiens (human)Kd0.028044
pd 173955Homo sapiens (human)Kd0.000711
s 1033Homo sapiens (human)Kd0.045011
bms 387032Homo sapiens (human)Kd10.000022
tandutinibHomo sapiens (human)Kd0.004933
vx-745Homo sapiens (human)Kd2.600022
dasatinibHomo sapiens (human)Kd0.000633
zd 6474Homo sapiens (human)Kd1.200022
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamideHomo sapiens (human)Kd10.000011
alvocidibHomo sapiens (human)Kd2.800022
bosutinibHomo sapiens (human)Kd0.380011
su 11248Homo sapiens (human)Kd0.002233
jnj-7706621Homo sapiens (human)Kd4.200011
vx680Homo sapiens (human)Kd1.800022
ekb 569Homo sapiens (human)Kd4.300011
axitinibHomo sapiens (human)Kd0.021011
pd 184352Homo sapiens (human)Kd10.000011
bms345541Homo sapiens (human)Kd10.000011
midostaurinHomo sapiens (human)Kd0.330033
ki 20227Homo sapiens (human)Kd0.000811
cp 724714Homo sapiens (human)Kd10.000011
pi103Homo sapiens (human)Kd10.000022
hki 272Homo sapiens (human)Kd0.670011
tofacitinibHomo sapiens (human)Kd10.000022
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamideHomo sapiens (human)Kd10.000011
cediranibHomo sapiens (human)Kd0.013011
masitinibHomo sapiens (human)Kd0.007611
pazopanibHomo sapiens (human)Kd0.007922
azd 6244Homo sapiens (human)Kd10.000011
su 14813Homo sapiens (human)Kd0.003622
bibw 2992Homo sapiens (human)Kd10.000011
tg100-115Homo sapiens (human)Kd10.000011
pha 665752Homo sapiens (human)Kd0.700011
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-oneHomo sapiens (human)Kd0.031011
brivanibHomo sapiens (human)Kd1.900011
at 7519Homo sapiens (human)Kd10.000011
bi 2536Homo sapiens (human)Kd10.000011
nvp-ast487Homo sapiens (human)Kd0.005822
kw 2449Homo sapiens (human)Kd0.120011
abt 869Homo sapiens (human)Kd0.003422
gw 2580Homo sapiens (human)Kd0.001922
crizotinibHomo sapiens (human)Kd0.210011
chir-265Homo sapiens (human)Kd0.250022
motesanibHomo sapiens (human)Kd0.005622
mln8054Homo sapiens (human)Kd10.000022
GDC-0879Homo sapiens (human)Kd10.000011
gsk 461364Homo sapiens (human)Kd10.000011
azd 1152-hqpaHomo sapiens (human)Kd1.400022
nvp-tae684Homo sapiens (human)Kd0.048011
fedratinibHomo sapiens (human)Kd0.620011
gsk690693Homo sapiens (human)Kd10.000011
gdc 0941Homo sapiens (human)Kd10.000011
plx 4720Homo sapiens (human)Kd2.700011
sgx 523Homo sapiens (human)Kd10.000011
quizartinibHomo sapiens (human)Kd0.010466
incb-018424Homo sapiens (human)Kd10.000011
gsk 1838705aHomo sapiens (human)Kd10.000011
gsk 1363089Homo sapiens (human)Kd0.001811
blz 945Homo sapiens (human)Kd0.003411
cep-32496Homo sapiens (human)Kd0.009011
chir 258Homo sapiens (human)Kd0.060022
nintedanibHomo sapiens (human)Kd0.048011
pp242Homo sapiens (human)Kd3.300011

Enables

This protein enables 8 target(s):

TargetCategoryDefinition
protein tyrosine kinase activitymolecular functionCatalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. [RHEA:10596]
macrophage colony-stimulating factor receptor activitymolecular functionCombining with macrophage colony-stimulating factor (M-CSF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. [GOC:mah, GOC:signaling]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
ATP bindingmolecular functionBinding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
protein phosphatase bindingmolecular functionBinding to a protein phosphatase. [GOC:jl]
cytokine bindingmolecular functionBinding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. [GOC:ai, GOC:bf, ISBN:0198599471]
protein homodimerization activitymolecular functionBinding to an identical protein to form a homodimer. [GOC:jl]
growth factor bindingmolecular functionBinding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. [GOC:curators]

Located In

This protein is located in 4 target(s):

TargetCategoryDefinition
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell surfacecellular componentThe external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
intracellular membrane-bounded organellecellular componentOrganized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Part Of

This protein is part of 2 target(s):

TargetCategoryDefinition
CSF1-CSF1R complexcellular componentA protein complex consisting of a macrophage colony-stimulating factor (CSF1, also called M-CSF) dimer bound to a dimerized receptor (CSF1R, also called FMS). Receptor dimerization requires the presence of the ligand. [GOC:bf, GOC:BHF, GOC:nc, PMID:19017797]
receptor complexcellular componentAny protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:go_curators]

Involved In

This protein is involved in 42 target(s):

TargetCategoryDefinition
positive regulation of protein phosphorylationbiological processAny process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. [GOC:hjd]
response to ischemiabiological processAny process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply. [GOC:hjd]
inflammatory responsebiological processThe immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
signal transductionbiological processThe cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
cell surface receptor protein tyrosine kinase signaling pathwaybiological processThe series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb, GOC:signaling]
axon guidancebiological processThe chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. [ISBN:0878932437]
cell population proliferationbiological processThe multiplication or reproduction of cells, resulting in the expansion of a cell population. [GOC:mah, GOC:mb]
positive regulation of cell population proliferationbiological processAny process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
negative regulation of cell population proliferationbiological processAny process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators]
regulation of cell shapebiological processAny process that modulates the surface configuration of a cell. [GOC:dph, GOC:go_curators, GOC:tb]
peptidyl-tyrosine phosphorylationbiological processThe phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. [RESID:AA0039]
cytokine-mediated signaling pathwaybiological processThe series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling, PMID:19295629]
olfactory bulb developmentbiological processThe progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
forebrain neuron differentiationbiological processThe process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
hemopoiesisbiological processThe process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. [GOC:dgh, ISBN:0198506732]
monocyte differentiationbiological processThe process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. [GOC:mah]
macrophage differentiationbiological processThe process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage. [GOC:add, ISBN:0781735149]
osteoclast differentiationbiological processThe process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. [CL:0000092, GOC:add, ISBN:0781735149, PMID:12161749]
ruffle organizationbiological processA process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell. [GOC:mah, PMID:10036235]
positive regulation of chemokine productionbiological processAny process that activates or increases the frequency, rate, or extent of chemokine production. [GOC:mah]
regulation of actin cytoskeleton organizationbiological processAny process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. [GOC:mah]
cellular response to macrophage colony-stimulating factor stimulusbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus. [GOC:yaf, PMID:14687666]
macrophage colony-stimulating factor signaling pathwaybiological processThe series of molecular signals initiated by the binding of the cytokine macrophage colony-stimulating factor (M-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, GOC:uh, PMID:12138890, Wikipedia:Macrophage_colony-stimulating_factor]
positive regulation of tyrosine phosphorylation of STAT proteinbiological processAny process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. [GOC:jl, PMID:11426647]
negative regulation of apoptotic processbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
positive regulation by host of viral processbiological processA process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected. [GOC:jl]
innate immune responsebiological processInnate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]
regulation of bone resorptionbiological processAny process that modulates the frequency, rate or extent of bone tissue loss (resorption). [GOC:ai]
cell-cell junction maintenancebiological processThe maintenance of junctions between cells. [GOC:ai]
protein autophosphorylationbiological processThe phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). [ISBN:0198506732]
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionbiological processAny process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai]
mammary gland duct morphogenesisbiological processThe process in which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk. [GOC:dph, PMID:17120154]
positive regulation of protein tyrosine kinase activitybiological processAny process that increases the rate, frequency, or extent of protein tyrosine kinase activity. [GOC:dph, GOC:tb]
microglial cell proliferationbiological processThe expansion of a microglial cell population by cell division. [GOC:dph, PMID:17344397]
positive regulation of ERK1 and ERK2 cascadebiological processAny process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah]
cellular response to cytokine stimulusbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. [GOC:mah]
regulation of macrophage migrationbiological processAny process that modulates the frequency, rate or extent of macrophage migration. [GO_REF:0000058, GOC:TermGenie, PMID:25749876]
positive regulation of cell motilitybiological processAny process that activates or increases the frequency, rate or extent of cell motility. [GOC:mah]
positive regulation of cell migrationbiological processAny process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators]
regulation of MAPK cascadebiological processAny process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade. [GOC:go_curators]
positive regulation of kinase activitybiological processAny process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:mah]
multicellular organism developmentbiological processThe biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]