Mitochondrial sodium/calcium exchanger protein

A mitochondrial sodium/calcium exchanger protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6J4K2]

Synonyms

Na(+)/K(+)/Ca(2+)-exchange protein 6;
Sodium/calcium exchanger protein, mitochondrial;
Sodium/potassium/calcium exchanger 6;
Solute carrier family 24 member 6;
Solute carrier family 8 member B1

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (1)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
cgp 37157	Homo sapiens (human)	IC50	1.6000	1	1

Enables

This protein enables 4 target(s):

Target	Category	Definition
calcium:sodium antiporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in). [GOC:curators, PMID:16371597]
calcium:monoatomic cation antiporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in). [TC:2.A.19.-.-]
protein homodimerization activity	molecular function	Binding to an identical protein to form a homodimer. [GOC:jl]
calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in), which contributes to regulating the membrane potential of a cardiac muscle cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]

Located In

This protein is located in 5 target(s):

Target	Category	Definition
mitochondrial inner membrane	cellular component	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
mitochondrial crista	cellular component	Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria. [ISBN:0198506732]
mitochondrial membrane	cellular component	Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. [GOC:mah, NIF_Subcellular:sao1045389829]
sarcolemma	cellular component	The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. [ISBN:0198506732]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

Involved In

This protein is involved in 12 target(s):

Target	Category	Definition
monoatomic ion transport	biological process	The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai]
mitochondrial calcium ion transmembrane transport	biological process	The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion. [GOC:ai]
sodium ion transmembrane transport	biological process	A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:vw]
glucose homeostasis	biological process	Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. [GOC:go_curators]
regulation of insulin secretion	biological process	Any process that modulates the frequency, rate or extent of the regulated release of insulin. [GOC:ai]
regulation of cytosolic calcium ion concentration	biological process	Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. [GOC:ai, GOC:mah, GOC:rph]
mitochondrial calcium ion homeostasis	biological process	Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings. [GOC:ai, GOC:mah]
regulation of cardiac muscle cell membrane potential	biological process	Any process that modulates the establishment or extent of a membrane potential in a cardiac muscle cell (a cardiomyocyte). A membrane potential is the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
calcium export from the mitochondrion	biological process	A process in which a calcium ion (Ca2+) is transported out of the mitochondrial matrix, and into the cytosol. [GOC:dos, GOC:vw]
regulation of lymphocyte chemotaxis	biological process	Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis. [GOC:TermGenie]
regulation of store-operated calcium entry	biological process	Any process that modulates the frequency, rate or extent of store-operated calcium entry. [GOC:BHF]
intracellular calcium ion homeostasis	biological process	A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell. [GOC:ceb, GOC:mah]