Compounds > vadimezan
Page last updated: 2024-09-03

vadimezan and Necrosis

vadimezan has been researched along with Necrosis in 21 studies

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (38.10)18.2507
2000's11 (52.38)29.6817
2010's2 (9.52)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ching, LM; Henare, K; Kieda, C; Palmer, BD; Reddy, C; Sutherland, R; Wang, LC; Woon, ST1
Aghaei, M; Downey, CM; Jirik, FR; Schwendener, RA1
de Witte, P; Lerut, E; Marysael, T; Ni, Y1
Baguley, BC; Ching, LM; Kestell, P; Zhao, L1
Baguley, BC; Ching, LM1
Bellnier, DA; Camacho, SH; Cheney, RT; Gollnick, SO; Greco, WR1
Thorpe, PE1
Baguley, BC; Ching, LM; Drummond, CJ; Kieda, C; Reddy, CB; Schooltink, MA; Woon, ST1
Griffiths, JR; Kelland, LR; Kestell, P; Ludwig, C; McIntyre, DJ; McPhail, LD; Robinson, SP1
Albelda, SM; Blouin, A; Cheng, G; Ching, LM; Jassar, A; Kapoor, V; LaRosa, DF; Sun, J; Wallace, A1
De Witte, PA; Ni, Y; Van de Putte, M1
Bibby, MC; Double, JA; Laws, AL; Matthew, AM1
Baguley, BC; Ching, LM; Joseph, WR; Zhuang, L1
Baguley, BC; Gavin, JB; Wilson, WR; Zwi, LJ2
Baguley, BC; Cole, G; Li, Z; Thomsen, LL1
Baguley, BC; Li, Z; Thomsen, LL; Veszelovszky, E1
Baguley, BC; Ching, LM; Goldsmith, D; Joseph, WR; Körner, H; Sedgwick, JD1
Baguley, BC1
Lepler, S; Mercer, E; Rojiani, AM; Siemann, DW1
Baguley, BC; Ching, LM; Joseph, WR1

Reviews

2 review(s) available for vadimezan and Necrosis

ArticleYear
Vascular targeting agents as cancer therapeutics.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Jan-15, Volume: 10, Issue:2

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Cell Division; Clinical Trials as Topic; Diphosphates; Genetic Therapy; Humans; Hypoxia; Immunotoxins; Ligands; Models, Biological; Necrosis; Neoplasms; Organophosphorus Compounds; Peptides; Radioimmunotherapy; Stilbenes; Time Factors; Up-Regulation; Xanthones

2004
Small-molecule cytokine inducers causing tumor necrosis.
    Current opinion in investigational drugs (London, England : 2000), 2001, Volume: 2, Issue:7

    Topics: 5-Hydroxytryptophan; Animals; Antineoplastic Agents; Capillary Permeability; Cytokines; Endothelium, Vascular; Flavonoids; Humans; Interferon-alpha; Mice; Microcirculation; Necrosis; Neoplasms; NF-kappa B; Nitric Oxide; Tumor Necrosis Factor-alpha; Xanthenes; Xanthones

2001

Other Studies

19 other study(ies) available for vadimezan and Necrosis

ArticleYear
Synthesis and biological activity of azido analogues of 5,6-dimethylxanthenone-4-acetic acid for use in photoaffinity labeling.
    Journal of medicinal chemistry, 2007, Aug-09, Volume: 50, Issue:16

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Azides; Cells, Cultured; Colonic Neoplasms; Hemorrhage; Mice; Mice, Inbred C57BL; Necrosis; NF-kappa B; Photoaffinity Labels; Protein Binding; Spleen; Structure-Activity Relationship; Transplantation, Heterologous; Tumor Necrosis Factor-alpha; Xanthones

2007
DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization.
    PloS one, 2014, Volume: 9, Issue:6

    Topics: Adenocarcinoma; Animals; Carcinoma, Non-Small-Cell Lung; Cell Membrane Permeability; Cell Polarity; Clodronic Acid; Humans; Inflammation; Liposomes; Lung Neoplasms; Macrophages; Male; Membrane Proteins; Mice, Transgenic; Necrosis; Neovascularization, Pathologic; Nucleotides, Cyclic; Phenotype; ras Proteins; Subcutaneous Tissue; Tumor Suppressor Protein p53; Xanthones; Xenograft Model Antitumor Assays

2014
Influence of the vascular damaging agents DMXAA and ZD6126 on hypericin distribution and accumulation in RIF-1 tumors.
    Journal of cancer research and clinical oncology, 2011, Volume: 137, Issue:11

    Topics: Animals; Anthracenes; Antineoplastic Agents; Cell Line, Tumor; Mice; Mice, Inbred C3H; Necrosis; Neoplasms; Neovascularization, Pathologic; Organophosphorus Compounds; Perylene; Telomere-Binding Proteins; Xanthones

2011
The antitumour activity of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF receptor-1 knockout mice.
    British journal of cancer, 2002, Aug-12, Volume: 87, Issue:4

    Topics: Animals; Antigens, CD; Antineoplastic Agents; Colonic Neoplasms; Dose-Response Relationship, Drug; Mice; Mice, Inbred C57BL; Mice, Knockout; Necrosis; Neoplasm Transplantation; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Serotonin; Time Factors; Tumor Necrosis Factor-alpha; Xanthenes; Xanthones

2002
DMXAA: an antivascular agent with multiple host responses.
    International journal of radiation oncology, biology, physics, 2002, Dec-01, Volume: 54, Issue:5

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Hydroxyindoleacetic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Models, Chemical; Necrosis; Neoplasm Transplantation; Neovascularization, Pathologic; Nitric Oxide; Receptors, Tumor Necrosis Factor; Serotonin; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Xanthenes; Xanthones

2002
Treatment with the tumor necrosis factor-alpha-inducing drug 5,6-dimethylxanthenone-4-acetic acid enhances the antitumor activity of the photodynamic therapy of RIF-1 mouse tumors.
    Cancer research, 2003, Nov-15, Volume: 63, Issue:22

    Topics: Animals; Antibodies, Monoclonal; Cell Line, Tumor; Dihematoporphyrin Ether; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Female; Fibrosarcoma; Mice; Mice, Inbred C3H; Necrosis; Neoplasms, Experimental; Photochemotherapy; Tumor Necrosis Factor-alpha; Xanthones

2003
A comparison of the ability of DMXAA and xanthenone analogues to activate NF-kappaB in murine and human cell lines.
    Oncology research, 2005, Volume: 15, Issue:7-8

    Topics: Animals; Antineoplastic Agents; Biological Assay; Cell Line, Tumor; Colonic Neoplasms; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Lymphoma, B-Cell; Mice; Necrosis; NF-kappa B; Structure-Activity Relationship; Xanthenes; Xanthones

2005
Rat tumor response to the vascular-disrupting agent 5,6-dimethylxanthenone-4-acetic acid as measured by dynamic contrast-enhanced magnetic resonance imaging, plasma 5-hydroxyindoleacetic acid levels, and tumor necrosis.
    Neoplasia (New York, N.Y.), 2006, Volume: 8, Issue:3

    Topics: Angiogenesis Inhibitors; Animals; Area Under Curve; Biomarkers; Capillary Permeability; Cell Line, Tumor; Contrast Media; Dose-Response Relationship, Drug; Female; Gadolinium DTPA; Indoles; Magnetic Resonance Imaging; Necrosis; Neoplasm Transplantation; Neovascularization, Pathologic; Pituitary Neoplasms; Prolactinoma; Rats; Rats, Inbred WF; Subcutaneous Tissue; Xanthones

2006
The vascular disrupting agent, DMXAA, directly activates dendritic cells through a MyD88-independent mechanism and generates antitumor cytotoxic T lymphocytes.
    Cancer research, 2007, Jul-15, Volume: 67, Issue:14

    Topics: Animals; Antineoplastic Agents; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Chickens; Cytokines; Dendritic Cells; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; Necrosis; Neoplasm Transplantation; Ovalbumin; T-Lymphocytes, Cytotoxic; Xanthones

2007
Exploration of the mechanism underlying the tumor necrosis avidity of hypericin.
    Oncology reports, 2008, Volume: 19, Issue:4

    Topics: Animals; Anthracenes; Carbocyanines; Female; Fibrosarcoma; Lipoproteins; Mice; Mice, Inbred C3H; Necrosis; Perylene; Sarcoma, Experimental; Xanthones

2008
Preclinical in vitro and in vivo activity of 5,6-dimethylxanthenone-4-acetic acid.
    British journal of cancer, 1995, Volume: 71, Issue:6

    Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Colonic Neoplasms; Hemorrhage; Humans; Lung Neoplasms; Mice; Mice, Inbred Strains; Mice, Nude; Necrosis; Species Specificity; Tumor Cells, Cultured; Xanthenes; Xanthones

1995
Interaction between endotoxin and the antitumour agent 5,6-dimethylxanthenone-4-acetic acid in the induction of tumour necrosis factor and haemorrhagic necrosis of colon 38 tumours.
    Cancer chemotherapy and pharmacology, 1994, Volume: 35, Issue:2

    Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Synergism; Endotoxins; Lipopolysaccharides; Mice; Necrosis; Tumor Necrosis Factor-alpha; Xanthenes; Xanthones

1994
The morphological effects of the anti-tumor agents flavone acetic acid and 5,6-dimethyl xanthenone acetic acid on the colon 38 mouse tumor.
    Pathology, 1994, Volume: 26, Issue:2

    Topics: Adenocarcinoma; Adenosine Triphosphate; Animals; Apoptosis; Colonic Neoplasms; Flavonoids; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Microscopy, Electron; Necrosis; Phosphocreatine; Xanthenes; Xanthones

1994
Serotonin involvement in the antitumour and host effects of flavone-8-acetic acid and 5,6-dimethylxanthenone-4-acetic acid.
    Cancer chemotherapy and pharmacology, 1993, Volume: 33, Issue:1

    Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Cyproheptadine; Flavonoids; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Necrosis; Nitrates; Nitric Oxide; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tumor Necrosis Factor-alpha; Xanthenes; Xanthones

1993
Flavone acetic acid and 5,6-dimethylxanthenone-4-acetic acid: relationship between plasma nitrate elevation and the induction of tumour necrosis.
    European journal of cancer (Oxford, England : 1990), 1993, Volume: 29A, Issue:3

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Arginine; Canavanine; Colonic Neoplasms; Flavonoids; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Necrosis; Nitrates; Nitric Oxide; Nitroarginine; omega-N-Methylarginine; Xanthenes; Xanthones

1993
Induction of intratumoral tumor necrosis factor (TNF) synthesis and hemorrhagic necrosis by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF knockout mice.
    Cancer research, 1999, Jul-15, Volume: 59, Issue:14

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; Hemorrhage; Mice; Mice, Inbred C57BL; Mice, Knockout; Necrosis; Neoplasm Proteins; Neovascularization, Pathologic; RNA, Messenger; RNA, Neoplasm; Tumor Necrosis Factor-alpha; Xanthenes; Xanthones

1999
Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy.
    International journal of cancer, 2002, May-01, Volume: 99, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blood Vessels; Cisplatin; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Mice; Mice, Inbred C3H; Mice, Nude; Necrosis; Neovascularization, Pathologic; Sarcoma, Experimental; Stilbenes; Tumor Cells, Cultured; Xanthenes; Xanthones

2002
Antitumour responses to flavone-8-acetic acid and 5,6-dimethylxanthenone-4-acetic acid in immune deficient mice.
    British journal of cancer, 1992, Volume: 66, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Flavonoids; Mice; Mice, Inbred Strains; Mice, Nude; Necrosis; T-Lymphocytes; Thymectomy; Xanthenes; Xanthones

1992
Necrosis in non-tumour tissues caused by flavone acetic acid and 5,6-dimethyl xanthenone acetic acid.
    British journal of cancer, 1990, Volume: 62, Issue:6

    Topics: Animals; Antineoplastic Agents; Endometrium; Female; Flavonoids; Lymphoid Tissue; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Necrosis; Thrombosis; Xanthenes; Xanthones

1990