Page last updated: 2024-12-06

pranolium

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

pranolium: deriv of propranolol; RN given refers to parent cpd; synonym UM 272 refers to iodide; synonym SC 27761 refers to chloride; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID38089
CHEMBL ID1710851
SCHEMBL ID2109959
MeSH IDM0043295

Synonyms (31)

Synonym
nsc303858
OPREA1_577736
[2-hydroxy-3-(1-naphthyloxy)propyl]isopropyldimethylammonium-
1-(isopropyl(dimethyl)-lambda~5~-azanyl)-3-(1-naphthyloxy)-2-propanol
1-propanaminium, 2-hydroxy-n, n-dimethyl-n-(1-methylethyl)-3-(1-naphthalenyloxy)-
1-propanaminium, 2-hydroxy-n, n-dimethyl-n-(1-methylethyl)-3-(1-naphthalenyloxy)-, chloride
{[2-hydroxy-3-(1-naphthyloxy)propyl]isopropyldimethylammonium} chloride
pranolium chloride(usan)
[2-hydroxy-3-(1-naphthyloxy)propyl]-isopropyl-dimethyl-ammonium
NCGC00160378-01
OPREA1_768255
1-propanaminium, 2-hydroxy-n,n-dimethyl-n-(1-methylethyl)-3-(1-naphthalenyloxy)-
pranolium
2-hydroxy-n,n-dimethyl-n-(1-methylethyl)-3-(1-naphthalenyloxy)-1-propanaminium
n,n-dimethylpropranolol
n,n-dimethyl-1-isopropylamino-3-(1-naphthyloxy)propan-2-ol
dimethylpropranolol
um 272
(2-hydroxy-3-naphthalen-1-yloxypropyl)-dimethyl-propan-2-ylazanium
AKOS000605847
50643-33-9
74h68x6iul ,
unii-74h68x6iul
CHEMBL1710851
pranolium ion
pranolium cation
DTXSID0048422
SCHEMBL2109959
AKOS024303923
2-hydroxy-n-isopropyl-n,n-dimethyl-3-(naphthalen-1-yloxy)propan-1-aminium
Q27266280

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" Both anti-arrhythmic efficacy and bioavailability were compared to oral drug."( Sublingual absorption of the quaternary ammonium antiarrhythmic agent, UM-272.
Lucchesi, BR; Patterson, E; Stetson, P, 1983
)
0.27

Dosage Studied

ExcerptRelevanceReference
" dosage the radioactivity was largely cleared via the kidneys."( Disposition of pranolium chloride in dogs, baboons and monkeys.
Allan, L; Barrow, A; Haskins, NJ; Palmer, RF; Rogers, M; Rose, DA, 1981
)
0.62
" The areas under the plasma concentration curve at conversion of ventricular tachycardia to sinus rhythm were similar for both dosage groups with area under the plasma concentration curve proportional to myocardial UM-272 concentration."( Plasma and myocardial tissue concentrations of UM-272 (N,N-dimethylpropranolol) after oral administration in dogs.
Lucchesi, BR; Patterson, E; Stetson, P, 1980
)
0.26
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency1.99530.035520.977089.1251AID504332
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency40.53340.005612.367736.1254AID624032
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency31.62280.251215.843239.8107AID504327
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID504749qHTS profiling for inhibitors of Plasmodium falciparum proliferation2011Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (27)

TimeframeStudies, This Drug (%)All Drugs %
pre-199024 (88.89)18.7374
1990's2 (7.41)18.2507
2000's0 (0.00)29.6817
2010's1 (3.70)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other29 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]