glafenine has been researched along with Necrosis in 3 studies
Glafenine: An anthranilic acid derivative with analgesic properties used for the relief of all types of pain.
glafenine : A carboxylic ester that is 2,3-dihydroxypropyl anthranilate in which the amino group is substituted by a 7-chloroquinolin-4-yl group. A non-steroidal anti-inflammatory drug, glafenine and its hydrochloride salt were used for the relief of all types of pain, but high incidence of anaphylactic reactions resulted in their withdrawal from the market.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Glafenine was associated with hepatic injury in 38 cases." | 1.27 | Glafenine-associated hepatic injury. Analysis of 38 cases and review of the literature. ( Blok, AP; Bronkhorst, FB; Stricker, BH, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ypma, RT | 1 |
| Festen, JJ | 1 |
| De Bruin, CD | 1 |
| Koek, GH | 1 |
| Stricker, BH | 2 |
| Veldhuizen, RW | 1 |
| de Graaf, P | 1 |
| Blok, AP | 1 |
| Bronkhorst, FB | 1 |
3 other studies available for glafenine and Necrosis
| Article | Year |
|---|---|
Hepatotoxicity of glafenine.
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Glafenine; Humans; Liver; Middle Aged; Necros | 1978 |
[Fatal liver cell necrosis following administration of glafenine].
Topics: Aged; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Glafenine; Hepatic Encephalopat | 1991 |
Glafenine-associated hepatic injury. Analysis of 38 cases and review of the literature.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Female; Glafenine; H | 1986 |