Compounds > chlorisondamine
Page last updated: 2024-09-20

chlorisondamine

Description

Chlorisondamine: A nicotinic antagonist used primarily as a ganglionic blocker in animal research. It has been used as an antihypertensive agent but has been supplanted by more specific drugs in most clinical applications. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6244
CHEMBL ID1398654
CHEBI ID135514
SCHEMBL ID14340042
MeSH IDM0004145

Synonyms (26)

Synonym
chlorisondamine
PDSP1_000172
PDSP2_000171
NCGC00024930-01
tocris-1001
NCGC00163230-01
CHEBI:135514
NCGC00024930-02
7701-62-4
4,5,6,7-tetrachloro-2-methyl-2-(2-(trimethylammonio)ethyl)isoindolinium
unii-jd3m24f66i
isoindolinium, 4,5,6,7-tetrachloro-2-methyl-2-(2-(trimethylammonio)ethyl)-
jd3m24f66i ,
cas_6243
bdbm84948
nsc_6243
CHEMBL1398654
chlorisondamine ion
chlorisondamine cation
isoindolinium, 4,5,6,7-tetrachloro-2-methyl-2-(2- (trimethylammonio)ethyl)-
chlorisondamine [who-dd]
1h-isoindolium, 4,5,6,7-tetrachloro-2,3-dihydro-2-methyl-2-(2- (trimethylammonio)ethyl)-
SCHEMBL14340042
DTXSID0048395
Q5102966
chlorisondamine-diiodide

Research Excerpts

Overview

ExcerptReference
"Chlorisondamine is a charged molecule that acts as long-acting nicotinic antagonist in many species, including pigeon. "( Chadman, KK; Stitzel, J; Woods, JH, 2007)

Effects

ExcerptReference
"Chlorisondamine (CSD) has been used to assess the neurogenic contribution to blood pressure (BP) and vasomotor sympathetic tone in animal models. "( Cooper, SG; Feng Earley, Y; Souza, LA; Thakore, P; Worker, CJ, 2021)

Actions

ExcerptReference
"3. Chlorisondamine failed to lower heart rate significantly in 4 or 7 day old rats, but lowered the rate by 50 to 80 beats per min in the older animals and eliminated the difference in rate between 16 day old and the other ages; atropine had little or no effect on heart rate."( Seidler, FJ; Slotkin, TA, 1979)
"Chlorisondamine inhibited the increase in ganglionic DOPAC following preganglionic stimulation (5 Hz, 30 min) by 30-50% and it even better reduced the biochemical changes in the salivary gland."( Andén, NE; Grabowska-Andén, M; Klaesson, L, 1986)

Treatment

ExcerptReference
"Chlorisondamine treatment exacerbated the decrease in mean arterial pressure in male mice infused with sPRR."( Gatineau, E; Gong, MC; Yiannikouris, F, 2019)
"Chlorisondamine pretreatment depressed heart rate, blood pressure and plasma levels of NPY-LI."( Al-Saffar, A; Lundberg, JM; Saria, A; Theodorsson-Norheim, E, 1986)
"Pretreatment with chlorisondamine (0.2-5 micromol/kg, i.p.) only partially blocked the effects of ABT-594 at the higher doses tested."( Decker, MW; Honore, P; Lynch, JJ; Mikusa, JP; Wade, CL, 2005)
"Treatment with chlorisondamine, which blocks nicotinic ganglionic transmission, also increased SP, reproducing the effects of decentralization."( Black, IB; Kessler, JA, 1982)
"Pretreatment with chlorisondamine (EC) and phentolamine (PT) did not alter the HC-induced hyperglycemia but did result in higher plasma insulin levels in response to the higher glucose levels."( Fletcher, HP; Longano, CA, 1983)
"Pretreatment with chlorisondamine, a ganglionic blocking agent, inhibited the Il-6 responses, while it had little influence on the TNF responses."( Kitamura, H; Morimatsu, M; Okamoto, S; Saito, M; Shimamoto, Y; Terao, A, 1998)
"Pretreatment with chlorisondamine or verapamil prevented the cocaine-induced enhancement of the maximal response to noradrenaline and the response to isoproterenol, but it did not inhibit potentiation of submaximal doses."( Bechara, G; El-Bizri, NM; Khoury, HA; Sabra, R; Sharaf, LH, 2000)
"Pretreatment with chlorisondamine (1 mg/kg i.v."( Baudrie, V; Chaouloff, F, 1992)
"Treatment with chlorisondamine, which blocks synaptic transmission in sympathetic ganglia, produces a significant increase in SV levels in the SCG after 7 d of treatment."( Greif, KF, 1986)

Drug Classes (1)

ClassDescription
isoindoles
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (4)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
15-lipoxygenase, partialHomo sapiens (human)Potency15.84890.012610.691788.5700AID887
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency15.84890.00207.533739.8107AID891
cytochrome P450 2C19 precursorHomo sapiens (human)Potency5.01190.00255.840031.6228AID899
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency17.03900.251215.843239.8107AID504327
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID504749qHTS profiling for inhibitors of Plasmodium falciparum proliferation2011Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
AID766732Noncompetitive inhibition of nicotinic cholinergic receptor in rat PC12 cells assessed as inhibition of 100 to 1000 uM nicotine-induced [3H]-norepinephrine release at 5 uM after 30 mins by liquid scintillation counting analysis2013Bioorganic & medicinal chemistry, Sep-15, Volume: 21, Issue:18
Development of a pharmacophore model for the catecholamine release-inhibitory peptide catestatin: virtual screening and functional testing identify novel small molecule therapeutics of hypertension.
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (584)

TimeframeStudies, This Drug (%)All Drugs %
pre-1990389 (66.61)18.7374
1990's123 (21.06)18.2507
2000's53 (9.08)29.6817
2010's16 (2.74)24.3611
2020's3 (0.51)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (0.17%)5.53%
Reviews6 (0.99%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other597 (98.84%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
1-(3,4-dichlorophenyl)-3-(4-((1-ethyl-3-piperidyl)amino)-6-methyl-2-pyrimidinyl)guanidine[no description available]medium10
desoxycorticosterone acetate[no description available]medium10corticosteroid hormone
propranolol[no description available]medium500naphthalenes;
propanolamine;
secondary amine		anti-arrhythmia drug;
antihypertensive agent;
anxiolytic drug;
beta-adrenergic antagonist;
environmental contaminant;
human blood serum metabolite;
vasodilator agent;
xenobiotic
losartan[no description available]medium60biphenylyltetrazole;
imidazoles		angiotensin receptor antagonist;
anti-arrhythmia drug;
antihypertensive agent;
endothelin receptor antagonist
atropine[no description available]medium940
leptin[no description available]medium30
a 65186[no description available]medium10
hs 024[no description available]medium10
muscimol[no description available]medium30alkaloid;
isoxazoles;
primary amino compound		fungal metabolite;
GABA agonist;
oneirogen;
psychotropic drug
nicotine[no description available]medium6303-(1-methylpyrrolidin-2-yl)pyridineanxiolytic drug;
biomarker;
immunomodulator;
mitogen;
neurotoxin;
nicotinic acetylcholine receptor agonist;
peripheral nervous system drug;
phytogenic insecticide;
plant metabolite;
psychotropic drug;
teratogenic agent;
xenobiotic
dichlorvos[no description available]medium10alkenyl phosphate;
dialkyl phosphate;
organochlorine acaricide;
organophosphate insecticide		anthelminthic drug;
antibacterial agent;
antifungal agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor
3-(2,4-dimethoxybenzylidene)anabaseine[no description available]medium10dimethoxybenzene
6-hydroxynicotine[no description available]medium10monohydroxypyridine
3-bromocytisine[no description available]medium10
l 365260[no description available]medium10benzodiazepine
devazepide[no description available]medium101,4-benzodiazepinone;
indolecarboxamide		antineoplastic agent;
apoptosis inducer;
cholecystokinin antagonist;
gastrointestinal drug
methoxsalen[no description available]medium10aromatic ether;
psoralens		antineoplastic agent;
cross-linking reagent;
dermatologic drug;
photosensitizing agent;
plant metabolite
propofol[no description available]medium10phenolsanticonvulsant;
antiemetic;
intravenous anaesthetic;
radical scavenger;
sedative
phenylephrine[no description available]medium250phenols;
phenylethanolamines;
secondary amino compound		alpha-adrenergic agonist;
cardiotonic drug;
mydriatic agent;
nasal decongestant;
protective agent;
sympathomimetic agent;
vasoconstrictor agent
phentolamine[no description available]medium390imidazoles;
phenols;
substituted aniline;
tertiary amino compound		alpha-adrenergic antagonist;
vasodilator agent
isoflurane[no description available]medium30organofluorine compoundinhalation anaesthetic
mecamylamine[no description available]medium480primary aliphatic amine
corticosterone[no description available]medium18011beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
sarin[no description available]medium20fluorine molecular entity;
phosphinic ester
angiotensin ii[no description available]medium240amino acid zwitterion;
angiotensin II		human metabolite
epibatidine[no description available]medium50
urethane[no description available]medium40carbamate esterfungal metabolite;
mutagen
hexachlorobenzene[no description available]medium10aromatic fungicide;
chlorobenzenes		antifungal agrochemical;
carcinogenic agent;
persistent organic pollutant
2-amino-7-phosphonoheptanoic acid[no description available]medium10
n-methylaspartate[no description available]medium40amino dicarboxylic acid;
D-alpha-amino acid;
D-aspartic acid derivative;
secondary amino compound		neurotransmitter agent
1-amino-1,3-dicarboxycyclopentane[no description available]medium10
2-amino-5-phosphonovalerate[no description available]medium10non-proteinogenic alpha-amino acidNMDA receptor antagonist
cycloleucine[no description available]medium10non-proteinogenic alpha-amino acidEC 2.5.1.6 (methionine adenosyltransferase) inhibitor
hexamethonium[no description available]medium110quaternary ammonium salt
ng-nitroarginine methyl ester[no description available]medium90alpha-amino acid ester;
L-arginine derivative;
methyl ester;
N-nitro compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor
indomethacin[no description available]medium60aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
pd 145065[no description available]medium10
scopolamine hydrobromide[no description available]medium90
palmidrol[no description available]medium10endocannabinoid;
N-(long-chain-acyl)ethanolamine;
N-(saturated fatty acyl)ethanolamine		anti-inflammatory drug;
anticonvulsant;
antihypertensive agent;
neuroprotective agent
indole[no description available]medium10indole;
polycyclic heteroarene		Escherichia coli metabolite
cardiovascular agents[no description available]medium20
chlorine[no description available]medium40halide anion;
monoatomic chlorine		cofactor;
Escherichia coli metabolite;
human metabolite
reserpine[no description available]medium691alkaloid ester;
methyl ester;
yohimban alkaloid		adrenergic uptake inhibitor;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
first generation antipsychotic;
plant metabolite;
xenobiotic
neostigmine[no description available]medium90quaternary ammonium ionantidote to curare poisoning;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
hydralazine[no description available]medium180azaarene;
hydrazines;
ortho-fused heteroarene;
phthalazines		antihypertensive agent;
vasodilator agent
pentolinium tartrate[no description available]medium200tartrate saltantihypertensive agent
arginine vasopressin[no description available]medium210vasopressincardiovascular drug;
hematologic agent;
mitogen
tyramine[no description available]medium110monoamine molecular messenger;
primary amino compound;
tyramines		EC 3.1.1.8 (cholinesterase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter
pituitrin[no description available]medium180
gallamine triethiodide[no description available]medium50
pempidine[no description available]medium200piperidines
guanidine[no description available]medium10carboxamidine;
guanidines;
one-carbon compound
succinylcholine[no description available]medium40quaternary ammonium ion;
succinate ester		drug allergen;
muscle relaxant;
neuromuscular agent
decamethonium[no description available]medium20quaternary ammonium ionmuscle relaxant;
nicotinic acetylcholine receptor agonist
tubocurarine[no description available]medium80bisbenzylisoquinoline alkaloiddrug allergen;
muscle relaxant;
nicotinic antagonist
dihydroxyphenylalanine[no description available]medium120hydroxyphenylalanine;
non-proteinogenic alpha-amino acid;
tyrosine derivative		human metabolite
trimethaphan[no description available]medium60sulfonium compoundanaesthesia adjuvant;
antihypertensive agent;
nicotinic antagonist;
vasodilator agent
chlorothiazide[no description available]medium30benzothiadiazineantihypertensive agent;
diuretic
pheniprazine[no description available]medium10amphetamines
hydrazine[no description available]medium40azane;
hydrazines		EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
histamine[no description available]medium140aralkylamino compound;
imidazoles		human metabolite;
mouse metabolite;
neurotransmitter
iproniazid[no description available]medium40carbohydrazide;
pyridines
chlorprothixene[no description available]medium20chlorprothixene
chlorpromazine[no description available]medium120organochlorine compound;
phenothiazines;
tertiary amine		anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
phenothiazine antipsychotic drug
tryptamine[no description available]medium10aminoalkylindole;
aralkylamino compound;
indole alkaloid;
tryptamines		human metabolite;
mouse metabolite;
plant metabolite
dimethylphenylpiperazinium iodide[no description available]medium100N-arylpiperazine;
organic iodide salt;
piperazinium salt;
quaternary ammonium salt		nicotinic acetylcholine receptor agonist
dihydroergotoxine[no description available]medium20
procaine[no description available]medium30benzoate ester;
substituted aniline;
tertiary amino compound		central nervous system depressant;
drug allergen;
local anaesthetic;
peripheral nervous system drug
ergotamine[no description available]medium60peptide ergot alkaloidalpha-adrenergic agonist;
mycotoxin;
non-narcotic analgesic;
oxytocic;
serotonergic agonist;
vasoconstrictor agent
methylergonovine[no description available]medium20ergoline alkaloid
mephenesin[no description available]medium20aromatic ether;
glycerol ether
pentylenetetrazole[no description available]medium30organic heterobicyclic compound;
organonitrogen heterocyclic compound
meprobamate[no description available]medium20organic molecular entity
bemegride[no description available]medium10piperidones
picrotoxin[no description available]medium20
phenytoin[no description available]medium20imidazolidine-2,4-dioneanticonvulsant;
drug allergen;
sodium channel blocker;
teratogenic agent
phenobarbital[no description available]medium40barbituratesanticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative
diazepam[no description available]medium301,4-benzodiazepinone;
organochlorine compound		anticonvulsant;
anxiolytic drug;
environmental contaminant;
sedative;
xenobiotic
strychnine[no description available]medium40monoterpenoid indole alkaloid;
organic heteroheptacyclic compound		avicide;
cholinergic antagonist;
glycine receptor antagonist;
neurotransmitter agent;
rodenticide
phenoxybenzamine[no description available]medium300aromatic amine
cortisone[no description available]medium4011-oxo steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		human metabolite;
mouse metabolite
hydrochlorothiazide[no description available]medium50benzothiadiazine;
organochlorine compound;
sulfonamide		antihypertensive agent;
diuretic;
environmental contaminant;
xenobiotic
guanethidine[no description available]medium270azocanes;
guanidines		adrenergic antagonist;
antihypertensive agent;
sympatholytic agent
methyldopa[no description available]medium70L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid		alpha-adrenergic agonist;
antihypertensive agent;
hapten;
peripheral nervous system drug;
sympatholytic agent
desoxycorticosterone[no description available]medium5020-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
mineralocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
dextroamphetamine[no description available]medium1001-phenylpropan-2-amineadrenergic agent;
adrenergic uptake inhibitor;
dopamine uptake inhibitor;
dopaminergic agent;
neurotoxin;
sympathomimetic agent
morphine[no description available]medium170morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic
substance p[no description available]medium60peptideneurokinin-1 receptor agonist;
neurotransmitter;
vasodilator agent
physostigmine[no description available]medium170carbamate ester;
indole alkaloid		antidote to curare poisoning;
EC 3.1.1.8 (cholinesterase) inhibitor;
miotic
pentobarbital[no description available]medium90barbituratesGABAA receptor agonist
ephedrine[no description available]medium50phenethylamine alkaloid;
phenylethanolamines		bacterial metabolite;
environmental contaminant;
nasal decongestant;
plant metabolite;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic
amphetamine[no description available]medium50primary amine
aminophylline[no description available]medium20mixturebronchodilator agent;
cardiotonic drug
isoproterenol[no description available]medium200catechols;
secondary alcohol;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
sympathomimetic agent
tyrosine[no description available]medium80amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
lysergic acid diethylamide[no description available]medium40ergoline alkaloid;
monocarboxylic acid amide;
organic heterotetracyclic compound		dopamine agonist;
hallucinogen;
serotonergic agonist
vitamin d 2[no description available]medium10hydroxy seco-steroid;
seco-ergostane;
vitamin D		bone density conservation agent;
nutraceutical;
plant metabolite;
rodenticide
dibenzylchlorethamine[no description available]medium20
dichloroisoproterenol[no description available]medium10
bicuculline methiodide[no description available]medium20
bicuculline[no description available]medium40benzylisoquinoline alkaloid;
isoquinoline alkaloid;
isoquinolines		agrochemical;
central nervous system stimulant;
GABA-gated chloride channel antagonist;
GABAA receptor antagonist;
neurotoxin
angiotensinogen[no description available]medium10
cosyntropin[no description available]medium10
dihydro-beta-erythroidine[no description available]medium30delta-lactone;
organic heterotetracyclic compound;
tertiary amino compound		nicotinic antagonist
amitriptyline[no description available]medium20carbotricyclic compound;
tertiary amine		adrenergic uptake inhibitor;
antidepressant;
environmental contaminant;
tropomyosin-related kinase B receptor agonist;
xenobiotic
methiothepin[no description available]medium20aryl sulfide;
dibenzothiepine;
N-alkylpiperazine;
tertiary amino compound		antipsychotic agent;
dopaminergic antagonist;
geroprotector;
serotonergic antagonist
a 85380[no description available]medium20
dizocilpine maleate[no description available]medium20maleate salt;
tetracyclic antidepressant		anaesthetic;
anticonvulsant;
neuroprotective agent;
nicotinic antagonist;
NMDA receptor antagonist
naloxone[no description available]medium160morphinane alkaloid;
organic heteropentacyclic compound;
tertiary alcohol		antidote to opioid poisoning;
central nervous system depressant;
mu-opioid receptor antagonist
piperacillin[no description available]medium20
sulpiride[no description available]medium10benzamides;
N-alkylpyrrolidine;
sulfonamide		antidepressant;
antiemetic;
antipsychotic agent;
dopaminergic antagonist
cocaine[no description available]medium140benzoate ester;
methyl ester;
tertiary amino compound;
tropane alkaloid		adrenergic uptake inhibitor;
central nervous system stimulant;
dopamine uptake inhibitor;
environmental contaminant;
local anaesthetic;
mouse metabolite;
plant metabolite;
serotonin uptake inhibitor;
sodium channel blocker;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic
methyllycaconitine[no description available]medium10
aconitine[no description available]medium10
naltrexone[no description available]medium40cyclopropanes;
morphinane-like compound;
organic heteropentacyclic compound		antidote to opioid poisoning;
central nervous system depressant;
environmental contaminant;
mu-opioid receptor antagonist;
xenobiotic
beta-endorphin[no description available]medium40
trinitrobenzenesulfonic acid[no description available]medium10arenesulfonic acid;
C-nitro compound		epitope;
explosive;
reagent
anabaseine[no description available]medium10bipyridines
mocetinostat[no description available]medium10aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline		antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent
anabasine[no description available]medium30anabasine
arginine[no description available]medium60arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical
captopril[no description available]medium60alkanethiol;
L-proline derivative;
N-acylpyrrolidine;
pyrrolidinemonocarboxylic acid		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
bibp 3226[no description available]medium10
thiazolidines[no description available]medium10thiazolidine
n-methylnaloxone[no description available]medium10
edetic acid[no description available]medium10ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid		anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector
gallic acid[no description available]medium10trihydroxybenzoic acidantineoplastic agent;
antioxidant;
apoptosis inducer;
astringent;
cyclooxygenase 2 inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
geroprotector;
human xenobiotic metabolite;
plant metabolite
nicardipine[no description available]medium20benzenes;
C-nitro compound;
diester;
dihydropyridine;
methyl ester;
tertiary amino compound
8-(n,n-diethylamino)octyl-3,4,5-trimethoxybenzoate[no description available]medium10trihydroxybenzoic acid
pilocarpine[no description available]medium60pilocarpineantiglaucoma drug
synephrine[no description available]medium10ethanolamines;
phenethylamine alkaloid;
phenols		alpha-adrenergic agonist;
plant metabolite
diazoxide[no description available]medium50benzothiadiazine;
organochlorine compound;
sulfone		antihypertensive agent;
beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
diuretic;
K-ATP channel agonist;
sodium channel blocker;
sympathomimetic agent;
vasodilator agent
thyroxine[no description available]medium202-halophenol;
iodophenol;
L-phenylalanine derivative;
non-proteinogenic L-alpha-amino acid;
thyroxine zwitterion;
thyroxine		antithyroid drug;
human metabolite;
mouse metabolite;
thyroid hormone
dihydroergotamine[no description available]medium20ergot alkaloid;
semisynthetic derivative		dopamine agonist;
non-narcotic analgesic;
serotonergic agonist;
sympatholytic agent;
vasoconstrictor agent
cyclic gmp[no description available]medium303',5'-cyclic purine nucleotide;
guanyl ribonucleotide		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
clonidine[no description available]medium110clonidine;
imidazoline
yohimbine[no description available]medium40methyl 17-hydroxy-20xi-yohimban-16-carboxylatealpha-adrenergic antagonist;
dopamine receptor D2 antagonist;
serotonergic antagonist
glutamic acid[no description available]medium90glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
n(2)-dansyl-l-arginine-4-t-butylpiperidine amide[no description available]medium10
talipexole[no description available]medium10azepine
cinnarizine[no description available]medium10diarylmethane;
N-alkylpiperazine;
olefinic compound		anti-allergic agent;
antiemetic;
calcium channel blocker;
geroprotector;
H1-receptor antagonist;
histamine antagonist;
muscarinic antagonist
methoxamine[no description available]medium70amphetaminesalpha-adrenergic agonist;
antihypotensive agent
verapamil[no description available]medium30aromatic ether;
nitrile;
polyether;
tertiary amino compound
apomorphine[no description available]medium50aporphine alkaloidalpha-adrenergic drug;
antidyskinesia agent;
antiparkinson drug;
dopamine agonist;
emetic;
serotonergic drug
bradykinin[no description available]medium60oligopeptidehuman blood serum metabolite;
vasodilator agent
1-methyl-3-isobutylxanthine[no description available]medium103-isobutyl-1-methylxanthine
argipressin, deaminopenicillamine(1)-o-methyl-tyr(2)-[no description available]medium50
ether[no description available]medium10ether;
volatile organic compound		inhalation anaesthetic;
non-polar solvent;
refrigerant
meclofenamic acid[no description available]medium20aminobenzoic acid;
organochlorine compound;
secondary amino compound		analgesic;
anticonvulsant;
antineoplastic agent;
antipyretic;
antirheumatic drug;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-steroidal anti-inflammatory drug
2h-benzo(a)quinolizin-2-ol, 2-ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-[no description available]medium10
wy 26703[no description available]medium10
indoramin[no description available]medium10tryptamines
azepexole[no description available]medium10
wy 26392[no description available]medium10
p-chloroamphetamine[no description available]medium20
sotalol[no description available]medium20ethanolamines;
secondary alcohol;
secondary amino compound;
sulfonamide		anti-arrhythmia drug;
beta-adrenergic antagonist;
environmental contaminant;
xenobiotic
oxidopamine[no description available]medium70benzenetriol;
catecholamine;
primary amino compound		drug metabolite;
human metabolite;
neurotoxin
gamma-aminobutyric acid[no description available]medium50amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid		human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
carbachol[no description available]medium100ammonium salt;
carbamate ester		cardiotonic drug;
miotic;
muscarinic agonist;
nicotinic acetylcholine receptor agonist;
non-narcotic analgesic
ethybenztropine[no description available]medium20
methylatropine[no description available]medium70
sucrose[no description available]medium30glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
cholestyramine resin[no description available]medium10
minoxidil[no description available]medium20dialkylarylamine;
tertiary amino compound
prazosin[no description available]medium70aromatic ether;
furans;
monocarboxylic acid amide;
piperazines;
quinazolines		alpha-adrenergic antagonist;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
tramazoline[no description available]medium30tetralins
propantheline[no description available]medium10xanthenes
atenolol[no description available]medium20ethanolamines;
monocarboxylic acid amide;
propanolamine		anti-arrhythmia drug;
antihypertensive agent;
beta-adrenergic antagonist;
environmental contaminant;
sympatholytic agent;
xenobiotic
metiamide[no description available]medium10imidazoles
tetrodotoxin[no description available]medium50azatetracycloalkane;
oxatetracycloalkane;
quinazoline alkaloid		animal metabolite;
bacterial metabolite;
marine metabolite;
neurotoxin;
voltage-gated sodium channel blocker
vasoactive intestinal peptide[no description available]medium40
muscarine[no description available]medium30monosaccharide
carbon monoxide[no description available]medium20carbon oxide;
gas molecular entity;
one-carbon compound		biomarker;
EC 1.9.3.1 (cytochrome c oxidase) inhibitor;
human metabolite;
ligand;
metabolite;
mitochondrial respiratory-chain inhibitor;
mouse metabolite;
neurotoxin;
neurotransmitter;
P450 inhibitor;
probe;
signalling molecule;
vasodilator agent
enkephalin, leucine[no description available]medium40pentapeptide;
peptide zwitterion		analgesic;
delta-opioid receptor agonist;
human metabolite;
mu-opioid receptor agonist;
neurotransmitter;
rat metabolite
neuropeptide y[no description available]medium90
chloralose[no description available]medium30
ketanserin[no description available]medium10aromatic ketone;
organofluorine compound;
piperidines;
quinazolines		alpha-adrenergic antagonist;
antihypertensive agent;
cardiovascular drug;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
serotonergic antagonist
tryptophan[no description available]medium30erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
cytisine[no description available]medium30alkaloid;
bridged compound;
lactam;
organic heterotricyclic compound;
secondary amino compound		nicotinic acetylcholine receptor agonist;
phytotoxin;
plant metabolite
lobeline[no description available]medium20
clozapine[no description available]medium30benzodiazepine;
N-arylpiperazine;
N-methylpiperazine;
organochlorine compound		adrenergic antagonist;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
GABA antagonist;
histamine antagonist;
muscarinic antagonist;
second generation antipsychotic;
serotonergic antagonist;
xenobiotic
flupenthixol[no description available]medium10thioxanthenes
3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid[no description available]medium10
calcimycin[no description available]medium10benzoxazole
8-bromocyclic gmp[no description available]medium103',5'-cyclic purine nucleotide;
organobromine compound		muscle relaxant;
protein kinase G agonist
tetraethylammonium[no description available]medium10quaternary ammonium ion
fluoxetine[no description available]medium20(trifluoromethyl)benzenes;
aromatic ether;
secondary amino compound
desipramine[no description available]medium80dibenzoazepine;
secondary amino compound		adrenergic uptake inhibitor;
alpha-adrenergic antagonist;
antidepressant;
cholinergic antagonist;
drug allergen;
EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
H1-receptor antagonist;
serotonin uptake inhibitor
nisoxetine[no description available]medium20aromatic ether;
secondary amino compound		adrenergic uptake inhibitor;
antidepressant
ici 118551[no description available]medium20aromatic ether;
indanes;
secondary alcohol;
secondary amino compound		beta-adrenergic antagonist
nitroarginine[no description available]medium10guanidines;
L-arginine derivative;
N-nitro compound;
non-proteinogenic L-alpha-amino acid
nitrous oxide[no description available]medium10gas molecular entity;
nitrogen oxide		analgesic;
bacterial metabolite;
food packaging gas;
food propellant;
general anaesthetic;
greenhouse gas;
inhalation anaesthetic;
NMDA receptor antagonist;
raising agent;
refrigerant;
vasodilator agent
capsaicin[no description available]medium80capsaicinoidnon-narcotic analgesic;
TRPV1 agonist;
voltage-gated sodium channel blocker
evans blue[no description available]medium10organic sodium saltfluorochrome;
histological dye;
sodium channel blocker;
teratogenic agent
pyrilamine[no description available]medium10aromatic ether;
ethylenediamine derivative		H1-receptor antagonist
diclofenac[no description available]medium10amino acid;
aromatic amine;
dichlorobenzene;
monocarboxylic acid;
secondary amino compound		antipyretic;
drug allergen;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
timolol[no description available]medium20timololanti-arrhythmia drug;
antiglaucoma drug;
antihypertensive agent;
beta-adrenergic antagonist
methysergide[no description available]medium50ergoline alkaloid
pd 123319[no description available]medium10imidazopyridineangiotensin receptor antagonist;
endothelin receptor antagonist;
vasoconstrictor agent
angiotensin i[no description available]medium20angiotensin;
peptide zwitterion		human metabolite;
neurotransmitter agent
resiniferatoxin[no description available]medium10carboxylic ester;
diterpenoid;
enone;
monomethoxybenzene;
organic heteropentacyclic compound;
ortho ester;
phenols;
tertiary alpha-hydroxy ketone		analgesic;
neurotoxin;
plant metabolite;
TRPV1 agonist
tetradecanoylphorbol acetate[no description available]medium10acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
vanoxerine[no description available]medium10ether;
N-alkylpiperazine;
organofluorine compound;
tertiary amino compound		dopamine uptake inhibitor
sumatriptan[no description available]medium10sulfonamide;
tryptamines		serotonergic agonist;
vasoconstrictor agent
enalapril[no description available]medium30dicarboxylic acid monoester;
dipeptide		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
geroprotector;
prodrug
(4-(m-chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium chloride[no description available]medium20
pirenzepine[no description available]medium20pyridobenzodiazepineanti-ulcer drug;
antispasmodic drug;
muscarinic antagonist
sq-11725[no description available]medium10
cesium[no description available]medium10alkali metal atom
lidocaine[no description available]medium60benzenes;
monocarboxylic acid amide;
tertiary amino compound		anti-arrhythmia drug;
drug allergen;
environmental contaminant;
local anaesthetic;
xenobiotic
qx-314[no description available]medium10monocarboxylic acid amidelocal anaesthetic
metyrapone[no description available]medium10aromatic ketoneantimetabolite;
diagnostic agent;
EC 1.14.15.4 (steroid 11beta-monooxygenase) inhibitor
triiodothyronine[no description available]medium202-halophenol;
amino acid zwitterion;
iodophenol;
iodothyronine		human metabolite;
mouse metabolite;
thyroid hormone
saccharin[no description available]medium101,2-benzisothiazole;
N-sulfonylcarboxamide		environmental contaminant;
sweetening agent;
xenobiotic
oxytocin[no description available]medium40heterodetic cyclic peptide;
peptide hormone		oxytocic;
vasodilator agent
alprostadil[no description available]medium10prostaglandins Eanticoagulant;
human metabolite;
platelet aggregation inhibitor;
vasodilator agent
okadaic acid[no description available]medium10ketal
pyrroles[no description available]medium10pyrrole;
secondary amine
sl 84.0418[no description available]medium10
endothelin-1[no description available]medium10
hydroxyindoleacetic acid[no description available]medium20indole-3-acetic acidsdrug metabolite;
human metabolite;
mouse metabolite
cl 316243[no description available]medium10
piperidines[no description available]medium10
rivastigmine[no description available]medium10carbamate ester;
tertiary amino compound		cholinergic drug;
EC 3.1.1.8 (cholinesterase) inhibitor;
neuroprotective agent
tacrine[no description available]medium10acridines;
aromatic amine		EC 3.1.1.7 (acetylcholinesterase) inhibitor
methoctramine[no description available]medium10hydrochloridemuscarinic antagonist
4-fluorohexahydrosiladifenidol[no description available]medium10
carbamates[no description available]medium30amino-acid anion
dsp 4[no description available]medium10
icatibant[no description available]medium10
nitrites[no description available]medium10monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species		human metabolite
nitrates[no description available]medium10monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species
sibutramine[no description available]medium10organochlorine compound;
tertiary amino compound		anti-obesity agent;
serotonin uptake inhibitor
brl 35135[no description available]medium10
kainic acid[no description available]medium10dicarboxylic acid;
L-proline derivative;
non-proteinogenic L-alpha-amino acid;
pyrrolidinecarboxylic acid		antinematodal drug;
excitatory amino acid agonist
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid[no description available]medium10arenesulfonic acid;
azobenzenes;
methylpyridines;
monohydroxypyridine;
organic phosphate;
pyridinecarbaldehyde		purinergic receptor P2X antagonist
pyridoxal phosphate[no description available]medium10methylpyridines;
monohydroxypyridine;
pyridinecarbaldehyde;
vitamin B6 phosphate		coenzyme;
cofactor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
metformin[no description available]medium10guanidinesenvironmental contaminant;
geroprotector;
hypoglycemic agent;
xenobiotic
potassium chloride[no description available]medium40inorganic chloride;
inorganic potassium salt;
potassium salt		fertilizer
deoxyglucose[no description available]medium30
glucagon-like peptide 1 (7-36)amide[no description available]medium10
glucagon-like peptide 1[no description available]medium10
glucagon[no description available]medium40peptide hormone
oxyntomodulin[no description available]medium10
cotinine[no description available]medium10N-alkylpyrrolidine;
pyridines;
pyrrolidin-2-ones;
pyrrolidine alkaloid		antidepressant;
biomarker;
human xenobiotic metabolite;
plant metabolite
haloperidol[no description available]medium40aromatic ketone;
hydroxypiperidine;
monochlorobenzenes;
organofluorine compound;
tertiary alcohol		antidyskinesia agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist
nornicotine[no description available]medium10
3,4-dihydroxyphenylacetic acid[no description available]medium20catechols;
dihydroxyphenylacetic acid		human metabolite
halothane[no description available]medium30haloalkane;
organobromine compound;
organochlorine compound;
organofluorine compound		inhalation anaesthetic
caseins[no description available]medium10
genistein[no description available]medium107-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
penicillamine[no description available]medium10non-proteinogenic alpha-amino acid;
penicillamine		antirheumatic drug;
chelator;
copper chelator;
drug allergen
s-nitro-n-acetylpenicillamine[no description available]medium10
proadifen[no description available]medium20diarylmethane
meproadifen[no description available]medium10
ethidium[no description available]medium10phenanthridinesfluorochrome;
intercalator
quinacrine[no description available]medium10acridines;
aromatic ether;
organochlorine compound;
tertiary amino compound		antimalarial;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor
qx-222[no description available]medium10amino acid amide
triphenylmethylphosphonium[no description available]medium10
chlorpheniramine[no description available]medium20monochlorobenzenes;
pyridines;
tertiary amino compound		anti-allergic agent;
antidepressant;
antipruritic drug;
H1-receptor antagonist;
histamine antagonist;
serotonin uptake inhibitor
metaraminol[no description available]medium30phenylethanolaminesalpha-adrenergic agonist;
sympathomimetic agent;
vasoconstrictor agent
cycloheximide[no description available]medium20antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol		anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor
emepronium[no description available]medium10diarylmethane
bucladesine[no description available]medium103',5'-cyclic purine nucleotide
pancuronium[no description available]medium10acetate ester;
steroid ester		cholinergic antagonist;
muscle relaxant;
nicotinic antagonist
disulfoton[no description available]medium10organic thiophosphate;
organothiophosphate insecticide		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
isoflurophate[no description available]medium20dialkyl phosphate
tetracaine[no description available]medium10benzoate ester;
tertiary amino compound		local anaesthetic
bretylium tosylate[no description available]medium20organosulfonate salt;
quaternary ammonium salt		adrenergic antagonist;
anti-arrhythmia drug;
antihypertensive agent
dactinomycin[no description available]medium30actinomycinmutagen
metaproterenol[no description available]medium10aralkylamino compound;
phenylethanolamines;
resorcinols;
secondary alcohol;
secondary amino compound
manganese[no description available]medium10elemental manganese;
manganese group element atom		Escherichia coli metabolite;
micronutrient
aldosterone[no description available]medium1011beta-hydroxy steroid;
18-oxo steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid hormone;
mineralocorticoid;
primary alpha-hydroxy ketone;
steroid aldehyde		human metabolite;
mouse metabolite
harmine[no description available]medium10harmala alkaloidanti-HIV agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
metabolite
zolertine[no description available]medium10
4-iodo-2,5-dimethoxyphenylisopropylamine[no description available]medium30amphetamines;
dimethoxybenzene;
organoiodine compound
bw 501c[no description available]medium10
citric acid, anhydrous[no description available]medium10tricarboxylic acidantimicrobial agent;
chelator;
food acidity regulator;
fundamental metabolite
phorbol 12,13-dibutyrate[no description available]medium10butyrate ester;
phorbol ester;
tertiary alpha-hydroxy ketone
nitroglycerin[no description available]medium20nitroglycerolexplosive;
muscle relaxant;
nitric oxide donor;
prodrug;
tocolytic agent;
vasodilator agent;
xenobiotic
cholecystokinin[no description available]medium10
3,4-dihydroxyphenylglycol[no description available]medium30catechols;
tetrol		metabolite;
mouse metabolite
methoxyhydroxyphenylglycol[no description available]medium30methoxybenzenes;
phenols
xylamidine[no description available]medium10
vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(o- methyl-l-tyrosine)-8-l-arginine-[no description available]medium30
enkephalin, ala(2)-mephe(4)-gly(5)-[no description available]medium10
4-aminobenzoic acid[no description available]medium10aminobenzoic acid;
aromatic amino-acid zwitterion		allergen;
Escherichia coli metabolite;
plant metabolite
4-aminomethylbenzoic acid[no description available]medium10benzoic acids
4-aminobenzoic acid[no description available]medium10aminobenzoate;
aromatic amino-acid anion		Escherichia coli metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
pentagastrin[no description available]medium50organic molecular entity
szl 49[no description available]medium10
gbr 12935[no description available]medium10ether;
N-alkylpiperazine;
tertiary amino compound		dopamine uptake inhibitor
ly 53857[no description available]medium10
ergoline[no description available]medium10diamine;
ergoline alkaloid;
indole alkaloid fundamental parent;
indole alkaloid;
organic heterotetracyclic compound
eticlopride[no description available]medium10salicylamides
debrisoquin[no description available]medium20carboxamidine;
isoquinolines		adrenergic agent;
antihypertensive agent;
human metabolite;
sympatholytic agent
fenoldopam[no description available]medium10benzazepinealpha-adrenergic agonist;
antihypertensive agent;
dopamine agonist;
dopaminergic antagonist;
vasodilator agent
neurotensin[no description available]medium10peptide hormonehuman metabolite;
mitogen;
neurotransmitter;
vulnerary
hydrogen carbonate[no description available]medium10carbon oxoanioncofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
vasoactive intestinal peptide, 4-chloro-phe(6)-leu(17)-[no description available]medium10
glycine[no description available]medium20alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
bretylium[no description available]medium30quaternary ammonium ionadrenergic antagonist;
anti-arrhythmia drug;
antihypertensive agent
gamma-endorphin, des-tyr(1)-[no description available]medium10
gamma-endorphin[no description available]medium10
n-methylscopolamine[no description available]medium10
midazolam[no description available]medium10imidazobenzodiazepine;
monofluorobenzenes;
organochlorine compound		anticonvulsant;
antineoplastic agent;
anxiolytic drug;
apoptosis inducer;
central nervous system depressant;
GABAA receptor agonist;
general anaesthetic;
muscle relaxant;
sedative
viprostol[no description available]medium10
dinoprostone[no description available]medium10prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
enflurane[no description available]medium10ether;
organochlorine compound;
organofluorine compound		anaesthetic
saralasin[no description available]medium10oligopeptide
chloral hydrate[no description available]medium10aldehyde hydrate;
ethanediol;
organochlorine compound		general anaesthetic;
mouse metabolite;
sedative;
xenobiotic
enkephalin, methionine[no description available]medium10
gastrin-releasing peptide[no description available]medium10
gastrins[no description available]medium50
bis(4-methyl-1-homopiperazinylthiocarbonyl)disulfide[no description available]medium10
preproenkephalin[no description available]medium10
losulazine hydrochloride[no description available]medium10
pargyline[no description available]medium100aromatic amine
glycogen[no description available]medium20
glycerol[no description available]medium10alditol;
triol		algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent
choline[no description available]medium10cholinesallergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter;
nutrient;
plant metabolite;
Saccharomyces cerevisiae metabolite
methylphenidate[no description available]medium20beta-amino acid ester;
methyl ester;
piperidines
oxprenolol[no description available]medium20aromatic ether
quinidine[no description available]medium10cinchona alkaloidalpha-adrenergic antagonist;
anti-arrhythmia drug;
antimalarial;
drug allergen;
EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor;
EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor;
muscarinic antagonist;
P450 inhibitor;
potassium channel blocker;
sodium channel blocker
procainamide[no description available]medium10benzamidesanti-arrhythmia drug;
platelet aggregation inhibitor;
sodium channel blocker
fenclonine[no description available]medium10phenylalanine derivative
5-hydroxytryptophan[no description available]medium20hydroxytryptophanhuman metabolite;
neurotransmitter
benserazide[no description available]medium10carbohydrazide;
catechols;
primary alcohol;
primary amino compound		antiparkinson drug;
dopaminergic agent;
EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor
octopamine[no description available]medium20phenylethanolamines;
tyramines		neurotransmitter
nalorphine[no description available]medium10morphinane alkaloid
dronabinol[no description available]medium30benzochromene;
diterpenoid;
phytocannabinoid;
polyketide		cannabinoid receptor agonist;
epitope;
hallucinogen;
metabolite;
non-narcotic analgesic
sarcosine[no description available]medium10N-alkylglycine zwitterion;
N-alkylglycine;
N-methyl-amino acid;
N-methylglycines		Escherichia coli metabolite;
glycine receptor agonist;
glycine transporter 1 inhibitor;
human metabolite;
mouse metabolite
alanine[no description available]medium10alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
barium[no description available]medium10alkaline earth metal atom;
elemental barium
theophylline[no description available]medium10dimethylxanthineadenosine receptor antagonist;
anti-asthmatic drug;
anti-inflammatory agent;
bronchodilator agent;
drug metabolite;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
fungal metabolite;
human blood serum metabolite;
immunomodulator;
muscle relaxant;
vasodilator agent
diphenhydramine[no description available]medium30ether;
tertiary amino compound		anti-allergic agent;
antidyskinesia agent;
antiemetic;
antiparkinson drug;
antipruritic drug;
antitussive;
H1-receptor antagonist;
local anaesthetic;
muscarinic antagonist;
oneirogen;
sedative
papaverine[no description available]medium31benzylisoquinoline alkaloid;
dimethoxybenzene;
isoquinolines		antispasmodic drug;
vasodilator agent
tremorine[no description available]medium20N-alkylpyrrolidine
nortriptyline[no description available]medium10organic tricyclic compound;
secondary amine		adrenergic uptake inhibitor;
analgesic;
antidepressant;
antineoplastic agent;
apoptosis inducer;
drug metabolite
imipramine[no description available]medium20dibenzoazepineadrenergic uptake inhibitor;
antidepressant;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
tetrabenazine[no description available]medium10benzoquinolizine;
cyclic ketone;
tertiary amino compound
chlordiazepoxide[no description available]medium20benzodiazepine
amobarbital[no description available]medium10barbiturates
caffeine[no description available]medium20purine alkaloid;
trimethylxanthine		adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic
nialamide[no description available]medium20organonitrogen compound;
organooxygen compound
tolazoline[no description available]medium30imidazolesalpha-adrenergic antagonist;
antihypertensive agent;
vasodilator agent
s-adenosylmethionine[no description available]medium10organic cation;
sulfonium compound		coenzyme;
cofactor;
human metabolite;
micronutrient;
Mycoplasma genitalium metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
tripelennamine[no description available]medium20aromatic amine
levodopa[no description available]medium10amino acid zwitterion;
dopa;
L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid		allelochemical;
antidyskinesia agent;
antiparkinson drug;
dopaminergic agent;
hapten;
human metabolite;
mouse metabolite;
neurotoxin;
plant growth retardant;
plant metabolite;
prodrug
chlorthalidone[no description available]medium10isoindoles;
monochlorobenzenes;
sulfonamide
furosemide[no description available]medium10chlorobenzoic acid;
furans;
sulfonamide		environmental contaminant;
loop diuretic;
xenobiotic
acetazolamide[no description available]medium10monocarboxylic acid amide;
sulfonamide;
thiadiazoles		anticonvulsant;
diuretic;
EC 4.2.1.1 (carbonic anhydrase) inhibitor
cyproheptadine[no description available]medium10piperidines;
tertiary amine		anti-allergic agent;
antipruritic drug;
gastrointestinal drug;
H1-receptor antagonist;
serotonergic antagonist
quinazolines[no description available]medium10azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinazolines
disulfiram[no description available]medium10organic disulfide;
organosulfur acaricide		angiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor;
EC 3.1.1.1 (carboxylesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
ferroptosis inducer;
fungicide;
NF-kappaB inhibitor
amantadine[no description available]medium10adamantanes;
primary aliphatic amine		analgesic;
antiparkinson drug;
antiviral drug;
dopaminergic agent;
NMDA receptor antagonist;
non-narcotic analgesic
alkenes[no description available]medium10
histidine[no description available]medium10amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
trimethadione[no description available]medium10oxazolidinoneanticonvulsant;
geroprotector
triflupromazine[no description available]medium10organofluorine compound;
phenothiazines;
tertiary amine		anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic
trifluoperazine[no description available]medium10N-alkylpiperazine;
N-methylpiperazine;
organofluorine compound;
phenothiazines		antiemetic;
calmodulin antagonist;
dopaminergic antagonist;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor;
EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor;
phenothiazine antipsychotic drug
formaldehyde[no description available]medium10aldehyde;
one-carbon compound		allergen;
carcinogenic agent;
disinfectant;
EC 3.5.1.4 (amidase) inhibitor;
environmental contaminant;
Escherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
valerates[no description available]medium10short-chain fatty acid anion;
straight-chain saturated fatty acid anion		plant metabolite
ouabain[no description available]medium1011alpha-hydroxy steroid;
14beta-hydroxy steroid;
5beta-hydroxy steroid;
alpha-L-rhamnoside;
cardenolide glycoside;
steroid hormone		anti-arrhythmia drug;
cardiotonic drug;
EC 2.3.3.1 [citrate (Si)-synthase] inhibitor;
EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor;
ion transport inhibitor;
plant metabolite
fomesafen[no description available]medium140aromatic ether;
C-nitro compound;
monochlorobenzenes;
N-sulfonylcarboxamide;
organofluorine compound;
phenols		agrochemical;
EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide
trolamine salicylate[no description available]medium10
iodine[no description available]medium10diatomic iodinenutrient
2-propanol[no description available]medium10secondary alcohol;
secondary fatty alcohol		protic solvent
inositol 3-phosphate[no description available]medium10
s,n,n'-tripropylthiocarbamate[no description available]medium20tertiary amine
apnea[no description available]medium10purine nucleoside
humulene[no description available]medium30alpha-humulene
isomethyleugenol[no description available]medium10isomethyleugenol
indoprofen[no description available]low00gamma-lactam;
isoindoles;
monocarboxylic acid		EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
captan[no description available]low00isoindoles;
organochlorine compound;
organosulfur compound;
phthalimide fungicide		antifungal agrochemical
phthalimidine[no description available]low00gamma-lactam;
isoindoles
captafol[no description available]low00isoindoles;
organochlorine compound;
organosulfur compound;
phthalimide fungicide		antifungal agrochemical
dialifor[no description available]low00isoindoles
1-ethyl-2-benzo[cd]indolone[no description available]low00isoindoles
N-Benzylphthalimide[no description available]low00isoindoles
indobufen[no description available]low00isoindoles
garenoxacin[no description available]low00aromatic ether;
cyclopropanes;
isoindoles;
organofluorine compound;
quinolinemonocarboxylic acid;
quinolone antibiotic		antibacterial drug;
non-steroidal anti-inflammatory drug
rs 45041-190[no description available]low00isoindoles
pomalidomide[no description available]low00aromatic amine;
dicarboximide;
isoindoles;
piperidones		angiogenesis inhibitor;
antineoplastic agent;
immunomodulator
lenalidomide[no description available]low00aromatic amine;
dicarboximide;
isoindoles;
piperidones		angiogenesis inhibitor;
antineoplastic agent;
immunomodulator
2-amino-7-cyclohexyl-6,8-dioxo-4,5,5a,8a-tetrahydrothieno[2,3-e]isoindole-3-carboxylic acid ethyl ester[no description available]low00isoindoles
6,7-dimethoxy-2-(2-thiazolyl)-3H-isoindol-1-one[no description available]low00isoindoles
3-(4-ethylphenyl)imino-1-isoindolamine[no description available]low00isoindoles
N-(1-ethyl-2-oxo-6-benzo[cd]indolyl)benzamide[no description available]low00isoindoles
2-(2-ethoxyphenyl)-5,6-dimethyl-1,3-dihydroisoindole[no description available]low00isoindoles
4-(dimethylsulfamoyl)-N-(1-ethyl-2-oxo-6-benzo[cd]indolyl)benzamide[no description available]low00isoindoles
2-(5H-[1,2,4]triazolo[5,1-a]isoindol-2-yl)ethanethioamide[no description available]low00isoindoles
2-(4-methylphenyl)-1,9b-dihydropyrazolo[1,5-b]isoindol-5-one[no description available]low00isoindoles
N-[[1,3-dioxo-2-(phenylmethyl)-7,7a-dihydro-3aH-octahydro-1H-4,7-epoxyisoindol-4-yl]methyl]-4-methoxybenzamide[no description available]low00isoindoles
LSM-25805[no description available]low00isoindoles
2-(2-oxo-1-benzo[cd]indolyl)-N-(2-oxolanylmethyl)acetamide[no description available]low00isoindoles
LSM-28383[no description available]low00isoindoles
4-[[[(1-ethyl-2-oxo-6-benzo[cd]indolyl)amino]-oxomethyl]amino]benzoic acid ethyl ester[no description available]low00isoindoles
LSM-17343[no description available]low00isoindoles
LSM-17324[no description available]low00isoindoles
LSM-4844[no description available]low00isoindoles
LSM-32057[no description available]low00isoindoles
LSM-19437[no description available]low00isoindoles
2-(2-furanylmethyl)-3-[[2-(3-pyridinyl)-3H-benzimidazol-5-yl]amino]-3H-isoindol-1-one[no description available]low00isoindoles
3-[(5-chloro-2-pyridinyl)amino]-2-(2-pyridinyl)-3H-isoindol-1-one[no description available]low00isoindoles
N-cycloheptyl-1-hydroxy-3-oxo-2-propyl-1H-isoindole-5-carboxamide[no description available]low00isoindoles
4-[[3-oxo-2-(3-pyridinyl)-1H-isoindol-1-yl]amino]benzoic acid ethyl ester[no description available]low00isoindoles
4-[[[2-(4-methoxyphenyl)-3-oxo-1H-isoindol-4-yl]-oxomethyl]amino]-1-piperidinecarboxylic acid ethyl ester[no description available]low00isoindoles
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(2-methoxyethyl)-3-oxo-1H-isoindole-4-carboxamide[no description available]low00isoindoles
3-[[2-(2-furanylmethyl)-3-oxo-1H-isoindol-1-yl]amino]benzoic acid ethyl ester[no description available]low00isoindoles
2-(5-chloro-2-pyridinyl)-3-(4-ethoxyanilino)-3H-isoindol-1-one[no description available]low00isoindoles
2-(2-methoxyethyl)-7-[oxo-(4-propyl-1-piperazinyl)methyl]-3H-isoindol-1-one[no description available]low00isoindoles
4-[4-[[[1-(2-methylpropyl)-3-pyrrolidinyl]methylamino]-oxomethyl]-3-oxo-1H-isoindol-2-yl]-1-piperidinecarboxylic acid ethyl ester[no description available]low00isoindoles
2-(1,3-benzodioxol-5-ylmethyl)-3-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-3H-isoindol-1-one[no description available]low00isoindoles
4-[3-oxo-1-(3,4,5-trimethoxyanilino)-1H-isoindol-2-yl]-1-piperidinecarboxylic acid ethyl ester[no description available]low00isoindoles
3-(2-ethoxyanilino)-2-(2-furanylmethyl)-3H-isoindol-1-one[no description available]low00isoindoles
LSM-20631[no description available]low00isoindoles
cinidon-ethyl[no description available]low00ethyl ester;
isoindoles;
monochlorobenzenes		herbicide
at 13387[no description available]low00benzamides;
isoindoles;
N-alkylpiperazine;
resorcinols;
tertiary carboxamide		antineoplastic agent;
Hsp90 inhibitor
N-(2-furanylmethyl)-3-(2-furanylmethylimino)-1-isoindolamine[no description available]low00isoindoles
ConditionIndicatedRelationship StrengthStudiesTrials
Abdominal Compartment Syndrome0low10
Abdominal Migraine0low10
Absence Seizure0low50
Absence Seizures0low50
Ache0low60
Acidosis0low10
Action Tremor0low10
Active Hyperemia0low10
Acute Confusional Migraine0low10
Acute Disease0low20
Acute Hypercapnic Respiratory Failure0low10
Acute Hypoxemic Respiratory Failure0low10
Adenocarcinoma0low10
Adenocarcinoma, Basal Cell0low10
Adenocarcinoma, Granular Cell0low10
Adenocarcinoma, Oxyphilic0low10
Adenocarcinoma, Tubular0low10
Adenoma, Malignant0low10
Adipocere0low10
Adrenal Cancer0low20
Adrenal Gland Cancer0low20
Adrenal Gland Neoplasms0low20
Adrenal Neoplasm0low20
Age-Related Memory Disorders0low20
Aggression0low10
Aging0low100
Aldosteronism0low20
Algor Mortis0low10
Allergy, Drug0low30
Alloxan Diabetes0low10
Anaphylactic Reaction0low30
Anaphylactoid Reaction0low30
Anaphylactoid Shock0low30
Anaphylaxis0low30
Anasarca0low20
Anesthesia0low110
Anochlesia0low10
Anoxemia0low10
Anoxia0low10
Apnea0low10
Arrhythmia0low40
Arrhythmias, Cardiac0low40
Arrythmia0low40
Arterial Hyperemia0low10
Arterial Obstructive Diseases0low10
Arterial Occlusive Diseases0low10
Arthritis0low10
Asphyxia0low10
Asthenia0low10
Asthma0low10
Asthma, Bronchial0low10
Atherosclerotic Parkinsonism0low10
Atonic Absence Seizure0low50
Atonic Absence Seizures0low50
Atonic Seizure0low50
Atonic Seizures0low50
Auditory Vertigo0low10
Aural Vertigo0low10
Bacterial Disease0low10
Bacterial Infection0low10
Bacterial Infections0low10
Bleeding0low50
Blood Poisoning0low10
Blood Pressure, High0medium631
Blood Pressure, Low0low90
Bloodstream Infection0low10
Body Weight0low120
Bradyarrhythmia0low40
Bradyarrhythmias0low40
Bradycardia0low40
Brain Vascular Disorders0low10
Bronchial Asthma0low10
Bronchial Spasm0low10
Bronchospasm0low10
Burns0low30
Cancer of the Adrenal Gland0low20
Carcinoma, Cribriform0low10
Carcinoma, Granular Cell0low10
Carcinoma, Tubular0low10
Cardiac Arrhythmia0low40
Cardiac Arrhythmias0low40
Cardiac Diseases0low30
Cardiac Disorders0low30
Cardiac Dysrhythmia0low40
Cardiac Failure0low20
Cardiac Hypertrophy0low10
Cardiac Neurosis0low10
Cardiomegaly0low10
Cardiomyopathies0low30
Cardiomyopathies, Primary0low30
Cardiomyopathies, Secondary0low30
Cardiovascular Diseases0low10
Cardiovascular Stroke0low10
Catalepsy0low10
Central Hypothyroidism0low10
Cerea Flexibilitas0low10
Cerebrovascular Diseases0low10
Cerebrovascular Disorders0low10
Cerebrovascular Insufficiency0low10
Cerebrovascular Occlusion0low10
Cervical Migraine Syndrome0low10
Chronic Disease0low40
Chronic Illness0low40
Chronically Ill0low40
Circulatory Collapse0low20
Circulatory Failure0low20
Clonic Seizure0low50
Clonic Seizures0low50
Coarse Tremor0low10
Colitis0low10
Complex Partial Seizure0low50
Complex Partial Seizures0low50
Congenital Zika Syndrome0low10
Congenital Zika Virus Infection0low10
Congestive Heart Failure0low20
Conn Syndrome0low20
Conn's Syndrome0low20
Continuous Tremor0low10
Convulsion0low50
Convulsion, Non-Epileptic0low50
Convulsions0low50
Convulsive Seizure0low50
Convulsive Seizures0low50
Cor Pulmonale0low30
Cornea Injuries0low10
Corneal Abrasions0low10
Corneal Damage0low10
Corneal Injuries0low10
Corneal Scar0low10
Corneal Trauma0low10
Cruor0low10
Cruveilhier-Baumgarten Syndrome0low10
Cystitis0low10
Darkness Tremor0low10
Decerebrate Posturing0low40
Decerebrate State0low40
Decorticate Rigidity0low40
Decorticate State0low40
Deficiency, Oxygen0low10
Delayed Effects, Prenatal Exposure0low10
Depression, Endogenous0low10
Depression, Neurotic0low10
Depression, Unipolar0low10
Depressive Disorder0low10
Depressive Syndrome0low10
Diabetes Insipidus0low20
Diabetes Mellitus0low10
Diabetes Mellitus, Experimental0low10
Disease Models, Animal0low190
Disease, Pulmonary Heart0low30
Diseases, Pulmonary Heart0low30
Dropsy0low20
Drug Allergy0low30
Drug Hypersensitivity0low30
Drug Withdrawal Symptoms0low10
Eclampsia0low10
Edema0low20
Edema-Proteinuria-Hypertension Gestosis0low20
Effort Syndrome0low10
Endotoxemia0low10
Enlarged Heart0low10
EPH Complex0low20
EPH Gestosis0low20
EPH Toxemias0low20
Epileptic Seizure0low50
Epileptic Seizures0low50
Experimental Diabetes Mellitus0low10
Experimental Mammary Neoplasms0low10
Experimental Neoplasms0low10
Extravasation of Contrast Media0low10
Extravasation of Diagnostic and Therapeutic Materials0low10
Extravasation of Diagnostic, Therapeutic Materials0low10
Extravascular Hemolysis0low10
Fasting Hypoglycemia0low20
Fatty Liver0low10
Fever0low20
Fever, Zika0low10
Fine Tremor0low10
Flexibility, Waxy0low10
Friedreich Ataxia0low20
Friedreich Disease0low20
Friedreich Familial Ataxia0low20
Friedreich Hereditary Ataxia0low20
Friedreich Hereditary Spinal Ataxia0low20
Friedreich Spinocerebellar Ataxia0low20
Friedreich's Ataxia0low20
Friedreich's Disease0low20
Friedreich's Familial Ataxia0low20
Friedreich's Hereditary Ataxia0low20
Friedreich's Hereditary Spinal Ataxia0low20
Gastric Ulcer0low20
Gastroduodenal Ulcer0low20
Generalized Absence Seizure0low50
Generalized Absence Seizures0low50
Generalized Tonic-Clonic Seizures0low50
Gestosis, EPH0low20
Goldblatt Syndrome0low10
Haemolysis0low10
Headache, Migraine0low10
Heart Attack0low10
Heart Decompensation0low20
Heart Disease, Pulmonary0low30
Heart Diseases0low30
Heart Diseases, Pulmonary0low30
Heart Disorders0low30
Heart Enlargement0low10
Heart Failure0low20
Heart Failure, Congestive0low20
Heart Failure, Left-Sided0low20
Heart Failure, Right-Sided0low20
Heart Hypertrophy0low10
Hemicrania Migraine0low10
Hemolysis0low10
Hemorrhage0low50
Hemorrhagic Shock0low30
Hereditary Spinal Ataxia, Friedreich0low20
Hereditary Spinal Ataxia, Friedreich's0low20
Hereditary Spinal Sclerosis0low20
Hydrops0low20
Hyperaldosteronism0low20
Hypercapnia0low20
Hypercapnic Acute Respiratory Failure0low10
Hypercapnic Respiratory Failure0low10
Hyperemia0low10
Hyperglycemia0low20
Hyperglycemia, Postprandial0low20
Hyperkinetic Heart Syndrome0low10
Hypernatremia0low10
Hypersensitivity, Drug0low30
Hypertension0medium631
Hypertension-Edema-Proteinuria Gestosis0low20
Hypertension, Goldblatt0low10
Hypertension, Malignant0low10
Hypertension, Portal0low10
Hypertension, Pulmonary0low30
Hypertension, Renal0low20
Hypertension, Renovascular0low10
Hyperthyroid0low30
Hyperthyroidism0low30
Hypoglycemia0low20
Hyponatremia0low10
Hypotension0low90
Hypotension, Orthostatic0low20
Hypotension, Postural0low20
Hypotension, Vascular0low90
Hypothermia0low10
Hypothermia, Accidental0low10
Hypothyroidism0low10
Hypovolemic Shock0low20
Hypoxemia0low10
Hypoxemic Acute Respiratory Failure0low10
Hypoxemic Respiratory Failure0low10
Hypoxia0low10
Infection, Bacterial0low10
Infections, Bacterial0low10
Inflammation0low40
Injuries, Spinal Cord0low10
Innate Inflammatory Response0low40
Insulin Resistance0low10
Insulin Sensitivity0low10
Intention Tremor0low10
Intermittent Tremor0low10
Intestinal Obstruction0low20
Intra-Abdominal Hypertension0low10
Intraabdominal Hypertension0low10
Intracranial Vascular Disorders0low10
Intravascular Hemolysis0low10
Involuntary Quiver0low10
Ischemia0low20
Jacksonian Seizure0low50
Kidney Diseases0low10
Late Effects, Prenatal Exposure0low10
Left-Sided Heart Failure0low20
Liver Diseases0low10
Liver Dysfunction0low10
Liver Steatosis0low10
Livor Mortis0low10
Low Blood Pressure0low90
Malignant Hypertension0low10
Mammary Neoplasms, Experimental0low10
Marginal Ulcer0low20
Massive Tremor0low10
Melancholia0low10
Memory Deficits0low20
Memory Disorder, Semantic0low20
Memory Disorder, Spatial0low20
Memory Disorders0low20
Memory Disorders, Age-Related0low20
Memory Loss0low20
Meniere Disease0low10
Meniere's Disease0low10
Meniere's Syndrome0low10
Metabolic Acidosis0low10
Migraine0low10
Migraine Disorders0low10
Migraine Headache0low10
Migraine Variant0low10
Mononeuritis0low10
Mononeuritis Multiplex0low10
Mononeuropathies0low10
Mononeuropathy Multiplex0low10
Mononeuropathy Multiplex Syndrome0low10
Mu00E9niu00E8re Disease0low10
Mu00E9niu00E8re's Disease0low10
Mu00E9niu00E8re's Vertigo0low10
Muscle Contraction0low180
Myelopathy0low10
Myelopathy, Traumatic0low10
Myocardial Diseases0low30
Myocardial Diseases, Primary0low30
Myocardial Diseases, Secondary0low30
Myocardial Failure0low20
Myocardial Infarct0low10
Myocardial Infarction0low10
Myocardiopathies0low30
Myoclonic Jerk0low10
Myoclonic Jerking0low10
Myoclonic Seizure0low50
Myoclonic Seizures0low50
Myoclonus0low10
Myoclonus Simplex0low10
Myoclonus, Action0low10
Myoclonus, Eyelid0low10
Myoclonus, Intention0low10
Myoclonus, Lower Extremity0low10
Myoclonus, Nocturnal0low10
Myoclonus, Oculopalatal0low10
Myoclonus, Palatal0low10
Myoclonus, Segmental0low10
Myoclonus, Sleep0low10
Myoclonus, Upper Extremity0low10
Necrosis0low10
Neoplasms, Adrenal Gland0low20
Neoplasms, Experimental0low10
Neoplasms, Experimental Mammary0low10
Nerve Degeneration0low10
Nerve Pain0low10
Neuralgia0low10
Neuralgia, Atypical0low10
Neuralgia, Iliohypogastric Nerve0low10
Neuralgia, Ilioinguinal0low10
Neuralgia, Perineal0low10
Neuralgia, Stump0low10
Neuralgia, Supraorbital0low10
Neuralgia, Vidian0low10
Neuroblastoma0low10
Neurocirculatory Asthenia0low10
Neurodynia0low10
Neuromuscular Blockade0low10
Neuron Degeneration0low10
Neuropathic Pain0low10
Neurosis, Depressive0low10
Nicotine Addiction0low10
Nicotine Dependence0low10
Nicotine Use Disorder0low10
Non-Epileptic Seizure0low50
Non-Epileptic Seizures0low50
Nonepileptic Seizure0low50
Nonepileptic Seizures0low50
Obesity0low40
Orthostatic Hypotension0low20
Otogenic Vertigo0low10
Oxygen Deficiency0low10
Pain0low60
Pain, Burning0low60
Pain, Crushing0low60
Pain, Migratory0low60
Pain, Radiating0low60
Pain, Splitting0low60
Parkinson Disease, Secondary0low10
Parkinson Disease, Secondary Vascular0low10
Parkinson Disease, Symptomatic0low10
Parkinsonism, Secondary0low10
Parkinsonism, Symptomatic0low10
Paroxysmal Nerve Pain0low10
Partial Seizure0low50
Partial Seizures0low50
Passive Hyperemia0low10
Passive Tremor0low10
Peptic Ulcer0low20
Persistent Tremor0low10
Petit Mal Convulsion0low50
Pheochromocytoma0low20
Pheochromocytoma, Extra-Adrenal0low20
Pill Rolling Tremor0low10
Poisoning, Blood0low10
Polyarthritis0low10
Polymyoclonus0low10
Post-Traumatic Myelopathy0low10
Postabsorptive Hypoglycemia0low20
Postmortem Changes0low10
Postprandial Hyperglycemia0low20
Postprandial Hypoglycemia0low20
Pre-Eclampsia0low20
Preeclampsia0low20
Preeclampsia Eclampsia 10low20
Pregnancy0low90
Pregnancy Toxemias0low20
Prenatal Exposure Delayed Effects0low10
Primary Hyperaldosteronism0low20
Primary Hyperthyroidism0low30
Primary Hypothyroidism0low10
Primary Myocardial Diseases0low30
Proteinuria-Edema-Hypertension Gestosis0low20
Pulmonary Heart Disease0low30
Pulmonary Heart Diseases0low30
Pulmonary Hypertension0low30
Pyaemia0low10
Pyemia0low10
Pyohemia0low10
Pyrexia0low20
Reactive Hyperemia0low10
Reactive Hypoglycemia0low20
Respiratory Depression0low10
Respiratory Failure0low10
Respiratory Insufficiency0low10
Rest Tremor0low10
Resting Tremor0low10
Retention Disorders, Cognitive0low20
Right-Sided Heart Failure0low20
Rigidity, Decerebrate0low40
Rigidity, Decorticate0low40
Saturnine Tremor0low10
Sclerosis, Hereditary Spinal0low20
Secondary Hypothyroidism0low10
Secondary Myocardial Diseases0low30
Secondary Parkinsonism0low10
Secondary Vascular Parkinson Disease0low10
Seizure0low50
Seizures0low50
Seizures, Auditory0low50
Seizures, Clonic0low50
Seizures, Convulsive0low50
Seizures, Epileptic0low50
Seizures, Focal0low50
Seizures, Generalized0low50
Seizures, Gustatory0low50
Seizures, Motor0low50
Seizures, Olfactory0low50
Seizures, Sensory0low50
Seizures, Somatosensory0low50
Seizures, Tonic0low50
Seizures, Tonic-Clonic0low50
Seizures, Vertiginous0low50
Seizures, Vestibular0low50
Seizures, Visual0low50
Semantic Memory Disorder0low20
Senile Tremor0low10
Sensitivity and Specificity0low10
Sepsis0low10
Septicemia0low10
Severe Sepsis0low10
Shock0low20
Shock, Anaphylactic0low30
Shock, Hemorrhagic0low30
Shock, Traumatic0low10
Sick Headache0low10
Single Seizure0low50
Smoking Cessation0low10
Spatial Memory Disorder0low20
Spinal Cord Contusion0low10
Spinal Cord Diseases0low10
Spinal Cord Disorders0low10
Spinal Cord Injuries0low10
Spinal Cord Laceration0low10
Spinal Cord Transection0low10
Spinal Cord Trauma0low10
Static Tremor0low10
Status Migrainosus0low10
Steatohepatitis0low10
Steatosis of Liver0low10
Stomach Ulcer0low20
Streptozocin Diabetes0low10
Streptozotocin Diabetes0low10
Substance Withdrawal Syndrome0low10
Suffering, Physical0low60
Suffocation0low10
Symptomatic Parkinson Disease0low10
Tachyarrhythmia0low60
Tachycardia0low60
Thyroid-Stimulating Hormone Deficiency0low10
Tobacco Dependence0low10
Tobacco Use Disorder0low10
Tobacco-Use Disorder0low10
Tonic Clonic Seizure0low50
Tonic Seizure0low50
Tonic Seizures0low50
Tonic-Clonic Seizure0low50
Tonic-Clonic Seizures0low50
Toxemia Of Pregnancy0low20
Toxemias, Pregnancy0low20
Tremor0low10
Tremor, Limb0low10
Tremor, Muscle0low10
Tremor, Neonatal0low10
Tremor, Nerve0low10
Tremor, Perioral0low10
Tremor, Semirhythmic0low10
TSH Deficiency0low10
Unipolar Depression0low10
Uremia0low10
Ureteral Obstruction0low10
Urinary Tract Infections0low10
Vascular Diseases, Intracranial0low10
Vascular Hypotension0low90
Venous Congestion0low10
Venous Engorgement0low10
Ventilatory Depression0low10
Ventricular Fibrillation0low20
Vertigo, Aural0low10
Visceral Steatosis0low10
Weight Gain0low10
Withdrawal Symptoms0low10
Zika Fever0low10
Zika Virus Disease0low10
Zika Virus Infection0low10
ZikV Infection0low10

Research Highlights

Safety/Toxicity (1)

ArticleYear
CRF activates autonomic nervous system and reduces natural killer cytotoxicity.
The American journal of physiology, Volume: 255, Issue: 5 Pt 2		1988
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Long-term Use (4)

ArticleYear
Effect of insulin on regional vascular resistances in conscious rats.
The American journal of physiology, Volume: 270, Issue: 2 Pt 2		1996
Acute and chronic angiotensin hypertension: neural and nonneural components, time course, and dose dependency.
The American journal of physiology, Volume: 271, Issue: 1 Pt 2		1996
Regulation of nicotinic receptors in rat brain following quasi-irreversible nicotinic blockade by chlorisondamine and chronic treatment with nicotine.
British journal of pharmacology, Volume: 113, Issue: 3		1994
Effects of chronic nicotine administration on the denervated rat adrenal medulla.
British journal of pharmacology, Volume: 56, Issue: 2		1976
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pharmacokinetics (3)

ArticleYear
Chronic angiotensin II infusion attenuates the renal sympathoinhibitory response to acute volume expansion.
American journal of physiology. Regulatory, integrative and comparative physiology, Volume: 284, Issue: 4		2003
The measurement of norepinephrine clearance and spillover rate into plasma in conscious spontaneously hypertensive rats.
Naunyn-Schmiedeberg's archives of pharmacology, Volume: 338, Issue: 4		1988
Cardiovascular effects of and interaction between calcium blocking drugs and anesthetics in chronically instrumented dogs. V. Role of pharmacokinetics and the autonomic nervous system in the interactions between verapamil and inhalational anesthetics.
Anesthesiology, Volume: 67, Issue: 3		1987
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (11)

ArticleYear
Lipid-enriched enteral nutrition controls the inflammatory response in murine Gram-negative sepsis.
Critical care medicine, Volume: 38, Issue: 10		2010
Modulation of neuronal nicotinic acetylcholine receptors by halothane in rat cortical neurons.
Molecular pharmacology, Volume: 59, Issue: 4		2001
Post-junctional mechanisms involved in the potentiation of cardiac adrenergic responses by cocaine.
European journal of pharmacology, May-26, Volume: 397, Issue: 1		2000
Bradykinin B2-receptors mediate the pressor and renal hemodynamic effects of intravenous bradykinin in conscious rats.
Journal of the autonomic nervous system, Jan-15, Volume: 75, Issue: 1		1999
Role of muscarinic receptors in ganglionic transmission in rabbits.
Journal of the autonomic nervous system, Jan-05, Volume: 56, Issue: 3		1996
Pulmonary effects of endogenous and exogenous nitric oxide in the pig: relation to cigarette smoke inhalation.
British journal of pharmacology, Volume: 110, Issue: 2		1993
Activation of nicotinic acetylcholine receptors on cultured Drosophila and other insect neurones.
The Journal of physiology, Volume: 463		1993
An investigation into the selectivity of a novel series of benzoquinolizines for alpha 2-adrenoceptors in vivo.
British journal of pharmacology, Volume: 82, Issue: 1		1984
Alpha 1-adrenoceptor subtypes and the regulation of peripheral hemodynamics in the conscious rat.
European journal of pharmacology, Sep-21, Volume: 186, Issue: 2-3		1990
Cardiovascular effects of cocaine in conscious rats: relative significance of central sympathetic stimulation and peripheral neuronal monoamine uptake and release mechanisms.
The Journal of pharmacology and experimental therapeutics, Volume: 262, Issue: 2		1992
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]