Page last updated: 2024-11-02

pd 98059 and Necrosis

pd 98059 has been researched along with Necrosis in 10 studies

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"To investigate the effect of bufalin on proliferation and apoptosis through ERK/RSK2 pathway in esophageal squamous cell carcinoma xenografts in nude mice."3.83[Effect of bufalin on proliferation and apoptosis through ERK/RSK2 pathway in human esophageal carcinoma cell line xenografts in nude mice]. ( Ding, Y; Liu, XJ; Liu, YP; Wang, XL; Yang, HC; Yue, M, 2016)
" We aimed to determine whether isoflurane, the most commonly used volatile anesthetic in the USA, protects against endothelial apoptosis and necrosis and the mechanisms involved in this protection."3.78Isoflurane protects against human endothelial cell apoptosis by inducing sphingosine kinase-1 via ERK MAPK. ( Bakar, AM; Kim, M; Lee, HT; Park, SW, 2012)
" Neurotoxic factors produced from activated macrophage or microglial cells such as tumor necrosis factor-alpha (TNFalpha), gp120 and quinolinic acid have been implicated as agents for the cell death which often appears to occur by an apoptotic mechanism."3.71CPI-1189 attenuates effects of suspected neurotoxins associated with AIDS dementia: a possible role for ERK activation. ( Flitter, WD; Garland, WA; Irwin, I; Kusdra, L; Pulliam, L; Rempel, H, 2001)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (20.00)18.2507
2000's6 (60.00)29.6817
2010's2 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yue, M1
Liu, XJ1
Ding, Y1
Wang, XL1
Yang, HC1
Liu, YP1
Bakar, AM1
Park, SW1
Kim, M1
Lee, HT1
Guo, J1
Jiang, H1
Wang, S1
Lobner, D1
Liot, G1
Belsey, MJ1
Davies, AR1
Witchel, HJ1
Kozlowski, RZ1
Journot, L1
Villalba, M1
Bockaert, J1
Ryu, BR1
Ko, HW1
Jou, I1
Noh, JS1
Gwag, BJ1
Galán, A1
García-Bermejo, ML1
Troyano, A1
Vilaboa, NE1
de Blas, E1
Kazanietz, MG1
Aller, P1
Pulliam, L1
Irwin, I1
Kusdra, L1
Rempel, H1
Flitter, WD1
Garland, WA1
Scheuren, N1
Jacobs, M1
Ertl, G1
Schorb, W1

Reviews

1 review available for pd 98059 and Necrosis

ArticleYear
PACAP-38 protects cerebellar granule cells from apoptosis.
    Annals of the New York Academy of Sciences, 1998, Dec-11, Volume: 865

    Topics: Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebellum; DNA F

1998

Other Studies

9 other studies available for pd 98059 and Necrosis

ArticleYear
[Effect of bufalin on proliferation and apoptosis through ERK/RSK2 pathway in human esophageal carcinoma cell line xenografts in nude mice].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2016, May-23, Volume: 38, Issue:5

    Topics: Animals; Antineoplastic Agents; Apoptosis; Bufanolides; Carcinoma, Squamous Cell; Cell Line, Tumor;

2016
Isoflurane protects against human endothelial cell apoptosis by inducing sphingosine kinase-1 via ERK MAPK.
    International journal of molecular sciences, 2012, Volume: 13, Issue:1

    Topics: Anesthetics, Inhalation; Apoptosis; Cell Line; DNA Fragmentation; Endothelial Cells; Extracellular S

2012
[The effect of metallothionein on delaying protection of ischemia/reperfusion].
    Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery, 2002, Volume: 18, Issue:6

    Topics: Animals; Cell Hypoxia; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Ischemic Preco

2002
Role of MAPK/ERK in neurotrophin-4 potentiation of necrotic neuronal death.
    Neurochemical research, 2004, Volume: 29, Issue:12

    Topics: Animals; Butadienes; Cell Death; Cells, Cultured; Cyclosporine; Enzyme Activation; Flavonoids; Immun

2004
Inhibition of ERK and JNK decreases both osmosensitive taurine release and cell proliferation in glioma cells.
    Neurochemical research, 2007, Volume: 32, Issue:11

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Anthracenes; Apoptosis; Astrocytoma; Cell

2007
Phosphatidylinositol 3-kinase-mediated regulation of neuronal apoptosis and necrosis by insulin and IGF-I.
    Journal of neurobiology, 1999, Jun-15, Volume: 39, Issue:4

    Topics: Adenosine Triphosphate; Androstadienes; Animals; Apoptosis; Buthionine Sulfoximine; Calcium-Calmodul

1999
Stimulation of p38 mitogen-activated protein kinase is an early regulatory event for the cadmium-induced apoptosis in human promonocytic cells.
    The Journal of biological chemistry, 2000, Apr-14, Volume: 275, Issue:15

    Topics: Apoptosis; Cadmium; Calcium-Calmodulin-Dependent Protein Kinases; Caspases; Enzyme Activation; Flavo

2000
CPI-1189 attenuates effects of suspected neurotoxins associated with AIDS dementia: a possible role for ERK activation.
    Brain research, 2001, Mar-02, Volume: 893, Issue:1-2

    Topics: AIDS Dementia Complex; Apoptosis; Brain; Butanes; Cells, Cultured; Culture Media, Conditioned; Enzym

2001
Cyclooxygenase-2 in myocardium stimulation by angiotensin-II in cultured cardiac fibroblasts and role at acute myocardial infarction.
    Journal of molecular and cellular cardiology, 2002, Volume: 34, Issue:1

    Topics: Angiotensin II; Animals; Blotting, Western; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Egg Pro

2002