pd 98059 has been researched along with Necrosis in 10 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effect of bufalin on proliferation and apoptosis through ERK/RSK2 pathway in esophageal squamous cell carcinoma xenografts in nude mice." | 3.83 | [Effect of bufalin on proliferation and apoptosis through ERK/RSK2 pathway in human esophageal carcinoma cell line xenografts in nude mice]. ( Ding, Y; Liu, XJ; Liu, YP; Wang, XL; Yang, HC; Yue, M, 2016) |
| " We aimed to determine whether isoflurane, the most commonly used volatile anesthetic in the USA, protects against endothelial apoptosis and necrosis and the mechanisms involved in this protection." | 3.78 | Isoflurane protects against human endothelial cell apoptosis by inducing sphingosine kinase-1 via ERK MAPK. ( Bakar, AM; Kim, M; Lee, HT; Park, SW, 2012) |
| " Neurotoxic factors produced from activated macrophage or microglial cells such as tumor necrosis factor-alpha (TNFalpha), gp120 and quinolinic acid have been implicated as agents for the cell death which often appears to occur by an apoptotic mechanism." | 3.71 | CPI-1189 attenuates effects of suspected neurotoxins associated with AIDS dementia: a possible role for ERK activation. ( Flitter, WD; Garland, WA; Irwin, I; Kusdra, L; Pulliam, L; Rempel, H, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 6 (60.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yue, M | 1 |
| Liu, XJ | 1 |
| Ding, Y | 1 |
| Wang, XL | 1 |
| Yang, HC | 1 |
| Liu, YP | 1 |
| Bakar, AM | 1 |
| Park, SW | 1 |
| Kim, M | 1 |
| Lee, HT | 1 |
| Guo, J | 1 |
| Jiang, H | 1 |
| Wang, S | 1 |
| Lobner, D | 1 |
| Liot, G | 1 |
| Belsey, MJ | 1 |
| Davies, AR | 1 |
| Witchel, HJ | 1 |
| Kozlowski, RZ | 1 |
| Journot, L | 1 |
| Villalba, M | 1 |
| Bockaert, J | 1 |
| Ryu, BR | 1 |
| Ko, HW | 1 |
| Jou, I | 1 |
| Noh, JS | 1 |
| Gwag, BJ | 1 |
| Galán, A | 1 |
| García-Bermejo, ML | 1 |
| Troyano, A | 1 |
| Vilaboa, NE | 1 |
| de Blas, E | 1 |
| Kazanietz, MG | 1 |
| Aller, P | 1 |
| Pulliam, L | 1 |
| Irwin, I | 1 |
| Kusdra, L | 1 |
| Rempel, H | 1 |
| Flitter, WD | 1 |
| Garland, WA | 1 |
| Scheuren, N | 1 |
| Jacobs, M | 1 |
| Ertl, G | 1 |
| Schorb, W | 1 |
1 review available for pd 98059 and Necrosis
| Article | Year |
|---|---|
PACAP-38 protects cerebellar granule cells from apoptosis.
Topics: Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebellum; DNA F | 1998 |
9 other studies available for pd 98059 and Necrosis
| Article | Year |
|---|---|
[Effect of bufalin on proliferation and apoptosis through ERK/RSK2 pathway in human esophageal carcinoma cell line xenografts in nude mice].
Topics: Animals; Antineoplastic Agents; Apoptosis; Bufanolides; Carcinoma, Squamous Cell; Cell Line, Tumor; | 2016 |
Isoflurane protects against human endothelial cell apoptosis by inducing sphingosine kinase-1 via ERK MAPK.
Topics: Anesthetics, Inhalation; Apoptosis; Cell Line; DNA Fragmentation; Endothelial Cells; Extracellular S | 2012 |
[The effect of metallothionein on delaying protection of ischemia/reperfusion].
Topics: Animals; Cell Hypoxia; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Ischemic Preco | 2002 |
Role of MAPK/ERK in neurotrophin-4 potentiation of necrotic neuronal death.
Topics: Animals; Butadienes; Cell Death; Cells, Cultured; Cyclosporine; Enzyme Activation; Flavonoids; Immun | 2004 |
Inhibition of ERK and JNK decreases both osmosensitive taurine release and cell proliferation in glioma cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Anthracenes; Apoptosis; Astrocytoma; Cell | 2007 |
Phosphatidylinositol 3-kinase-mediated regulation of neuronal apoptosis and necrosis by insulin and IGF-I.
Topics: Adenosine Triphosphate; Androstadienes; Animals; Apoptosis; Buthionine Sulfoximine; Calcium-Calmodul | 1999 |
Stimulation of p38 mitogen-activated protein kinase is an early regulatory event for the cadmium-induced apoptosis in human promonocytic cells.
Topics: Apoptosis; Cadmium; Calcium-Calmodulin-Dependent Protein Kinases; Caspases; Enzyme Activation; Flavo | 2000 |
CPI-1189 attenuates effects of suspected neurotoxins associated with AIDS dementia: a possible role for ERK activation.
Topics: AIDS Dementia Complex; Apoptosis; Brain; Butanes; Cells, Cultured; Culture Media, Conditioned; Enzym | 2001 |
Cyclooxygenase-2 in myocardium stimulation by angiotensin-II in cultured cardiac fibroblasts and role at acute myocardial infarction.
Topics: Angiotensin II; Animals; Blotting, Western; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Egg Pro | 2002 |