A tubulin polymerization-promoting protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:O94811]
TPPP;
EC 3.6.5.-;
25 kDa brain-specific protein;
TPPP/p25;
p24;
p25-alpha
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| fosbretabulin | Homo sapiens (human) | IC50 | 1.0160 | 2 | 2 |
This protein enables 8 target(s):
| Target | Category | Definition |
|---|---|---|
| magnesium ion binding | molecular function | Binding to a magnesium (Mg) ion. [GOC:ai] |
| GTPase activity | molecular function | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. [PMID:26832457, PMID:27218782] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| microtubule binding | molecular function | Binding to a microtubule, a filament composed of tubulin monomers. [GOC:krc] |
| tubulin binding | molecular function | Binding to monomeric or multimeric forms of tubulin, including microtubules. [GOC:clt] |
| protein homodimerization activity | molecular function | Binding to an identical protein to form a homodimer. [GOC:jl] |
| protein dimerization activity | molecular function | The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. [ISBN:0198506732] |
| microtubule nucleator activity | molecular function | The action of a molecule that provides a shape mimicking the end of a microtubule to seed the formation of a new microtubule via self-assembly. [PMID:20631709, PMID:21993292] |
This protein is located in 8 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| microtubule organizing center | cellular component | An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| perinuclear region of cytoplasm | cellular component | Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid] |
| mitotic spindle | cellular component | A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178] |
| postsynaptic Golgi apparatus | cellular component | The network of the Golgi apparatus structures located within the postsynapse. [GOC:aruk, GOC:bc, PMID:23838184] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| Golgi apparatus | cellular component | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732] |
This protein is involved in 13 target(s):
| Target | Category | Definition |
|---|---|---|
| microtubule bundle formation | biological process | A process that results in a parallel arrangement of microtubules. [GOC:dph] |
| oligodendrocyte development | biological process | The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system. [GOC:dgh, GOC:ef] |
| astral microtubule organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles. [GOC:mah] |
| positive regulation of protein-containing complex assembly | biological process | Any process that activates or increases the frequency, rate or extent of protein complex assembly. [GOC:mah] |
| positive regulation of myelination | biological process | Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons. [GOC:mah] |
| positive regulation of protein polymerization | biological process | Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers. [GOC:mah] |
| myelin assembly | biological process | The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system. [GOC:dgh, GOC:dph, GOC:tb] |
| microtubule polymerization | biological process | The addition of tubulin heterodimers to one or both ends of a microtubule. [GOC:ai, GOC:go_curators] |
| oligodendrocyte differentiation | biological process | The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system. [GOC:vp, PMID:15139015] |
| cell division | biological process | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. [GOC:di, GOC:go_curators, GOC:pr] |
| microtubule nucleation by microtubule organizing center | biological process | The 'de novo' formation of a microtubule, mediated by the microtubule organizing center. [GOC:ai] |
| regulation of microtubule cytoskeleton organization | biological process | Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. [GOC:mah] |
| negative regulation of tubulin deacetylation | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylation. [GO_REF:0000058, GOC:TermGenie, PMID:23886946] |