Ectonucleoside triphosphate diphosphohydrolase 8

An ectonucleoside triphosphate diphosphohydrolase 8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5MY95]

E-NTPDase 8;
NTPDase 8;
NTPDase8;
EC 3.6.1.5

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
suramin	Homo sapiens (human)	Ki	100.0000	1	1

This protein enables 6 target(s):

Target	Category	Definition
apyrase activity	molecular function	Catalysis of the reaction: a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 phosphate. This reaction consists of two distinct successive phosphate-releasing steps, with NDPs as intermediates. Apyrases are active against both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs). [EC:3.6.1.5]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
UDP phosphatase activity	molecular function	Catalysis of the reaction: UDP + H2O = UMP + phosphate. [RHEA:64876]
ribonucleoside triphosphate phosphatase activity	molecular function	Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate. [RHEA:23680]
GDP phosphatase activity	molecular function	Catalysis of the reaction: GDP + H2O = GMP + phosphate. [PMID:2989286, RHEA:22156]

This protein is located in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is involved in 3 target(s):

Target	Category	Definition
nucleoside monophosphate biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar. [GOC:go_curators, ISBN:0198506732]
nucleoside diphosphate biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]
nucleoside diphosphate catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732]