Page last updated: 2024-08-07 23:16:59
Matrix protein 2
An influenzavirus matrix protein 2 that is encoded in the genome of the H3N2 strain A/Udorn/1972. [PRO:DAN, UniProtKB:P0DOF8]
Synonyms
Proton channel protein M2
Research
Bioassay Publications (8)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (2)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| amantadine | Influenza A virus (A/udorn/1972(H3N2)) | IC50 | 109.8600 | 5 | 5 |
| rimantadine | Influenza A virus (A/udorn/1972(H3N2)) | IC50 | 255.4000 | 4 | 4 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| amantadine | Influenza A virus (A/udorn/1972(H3N2)) | EC50 | 0.6600 | 2 | 2 |
| amantadine | Influenza A virus (A/udorn/1972(H3N2)) | Kd | 58.2925 | 4 | 4 |
| rimantadine | Influenza A virus (A/udorn/1972(H3N2)) | Kd | 3,335.8367 | 3 | 3 |
Design and synthesis of heteroaromatic-based benzenesulfonamide derivatives as potent inhibitors of H5N1 influenza A virus.MedChemComm, , Jan-01, Volume: 10, Issue:1, 2019
Unraveling the Binding, Proton Blockage, and Inhibition of Influenza M2 WT and S31N by Rimantadine Variants.ACS medicinal chemistry letters, , Mar-08, Volume: 9, Issue:3, 2018
Synthesis and structure-activity relationship study of arylsulfonamides as novel potent H5N1 inhibitors.European journal of medicinal chemistry, , Nov-05, Volume: 159, 2018
Binding and Proton Blockage by Amantadine Variants of the Influenza M2Journal of medicinal chemistry, , 03-09, Volume: 60, Issue:5, 2017
Discovery of Highly Potent Inhibitors Targeting the Predominant Drug-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel.Journal of medicinal chemistry, , Feb-11, Volume: 59, Issue:3, 2016
Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus.Journal of medicinal chemistry, , Jul-10, Volume: 57, Issue:13, 2014
3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant.Journal of medicinal chemistry, , Nov-27, Volume: 56, Issue:22, 2013
Unraveling the Binding, Proton Blockage, and Inhibition of Influenza M2 WT and S31N by Rimantadine Variants.ACS medicinal chemistry letters, , Mar-08, Volume: 9, Issue:3, 2018
3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant.Journal of medicinal chemistry, , Nov-27, Volume: 56, Issue:22, 2013
Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus.Journal of medicinal chemistry, , Apr-11, Volume: 56, Issue:7, 2013