Proteins > Ephrin type-B receptor 1
Page last updated: 2024-08-07 13:24:23

Ephrin type-B receptor 1

An ephrin type-B receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54762]

Synonyms

EC 2.7.10.1;
ELK;
EPH tyrosine kinase 2;
EPH-like kinase 6;
EK6;
hEK6;
Neuronally-expressed EPH-related tyrosine kinase;
NET;
Tyrosine-protein kinase receptor EPH-2

Research

Bioassay Publications (9)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (44.44)29.6817
2010's5 (55.56)24.3611
2020's0 (0.00)2.80

Compounds (75)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
staurosporineHomo sapiens (human)IC500.069433
birb 796Homo sapiens (human)IC500.110011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
sb 202190Homo sapiens (human)Kd10.000011
imatinibHomo sapiens (human)Kd10.000022
staurosporineHomo sapiens (human)Kd0.356733
gefitinibHomo sapiens (human)Kd6.200033
lestaurtinibHomo sapiens (human)Kd5.200022
vatalanibHomo sapiens (human)Kd10.000022
ruboxistaurinHomo sapiens (human)Kd10.000022
canertinibHomo sapiens (human)Kd4.300033
birb 796Homo sapiens (human)Kd4.666733
cyc 202Homo sapiens (human)Kd10.000011
sb 203580Homo sapiens (human)Kd10.000022
enzastaurinHomo sapiens (human)Kd10.000011
erlotinibHomo sapiens (human)Kd5.550022
lapatinibHomo sapiens (human)Kd10.000022
sorafenibHomo sapiens (human)Kd2.675044
pd 173955Homo sapiens (human)Kd0.004411
s 1033Homo sapiens (human)Kd1.300011
bms 387032Homo sapiens (human)Kd10.000022
tandutinibHomo sapiens (human)Kd10.000033
vx-745Homo sapiens (human)Kd5.933333
dasatinibHomo sapiens (human)Kd0.000422
zd 6474Homo sapiens (human)Kd0.373333
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamideHomo sapiens (human)Kd10.000011
alvocidibHomo sapiens (human)Kd4.566733
bosutinibHomo sapiens (human)Kd0.033011
su 11248Homo sapiens (human)Kd0.672055
jnj-7706621Homo sapiens (human)Kd10.000011
vx680Homo sapiens (human)Kd1.900022
ekb 569Homo sapiens (human)Kd7.100022
axitinibHomo sapiens (human)Kd10.000011
pd 184352Homo sapiens (human)Kd10.000011
bms345541Homo sapiens (human)Kd10.000011
midostaurinHomo sapiens (human)Kd10.000033
ki 20227Homo sapiens (human)Kd10.000011
cp 724714Homo sapiens (human)Kd10.000011
pi103Homo sapiens (human)Kd10.000022
hki 272Homo sapiens (human)Kd10.000011
tofacitinibHomo sapiens (human)Kd10.000022
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamideHomo sapiens (human)Kd10.000011
cediranibHomo sapiens (human)Kd10.000011
masitinibHomo sapiens (human)Kd10.000011
pazopanibHomo sapiens (human)Kd10.000022
azd 6244Homo sapiens (human)Kd10.000011
su 14813Homo sapiens (human)Kd7.150022
bibw 2992Homo sapiens (human)Kd10.000011
tg100-115Homo sapiens (human)Kd10.000011
pha 665752Homo sapiens (human)Kd10.000011
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-oneHomo sapiens (human)Kd0.390011
brivanibHomo sapiens (human)Kd10.000011
at 7519Homo sapiens (human)Kd10.000011
bi 2536Homo sapiens (human)Kd10.000011
nvp-ast487Homo sapiens (human)Kd0.180022
kw 2449Homo sapiens (human)Kd2.500011
abt 869Homo sapiens (human)Kd5.440022
gw 2580Homo sapiens (human)Kd10.000022
crizotinibHomo sapiens (human)Kd0.120011
chir-265Homo sapiens (human)Kd10.000022
motesanibHomo sapiens (human)Kd10.000022
mln8054Homo sapiens (human)Kd0.330022
GDC-0879Homo sapiens (human)Kd10.000011
gsk 461364Homo sapiens (human)Kd10.000011
azd 1152-hqpaHomo sapiens (human)Kd10.000022
nvp-tae684Homo sapiens (human)Kd0.340011
fedratinibHomo sapiens (human)Kd1.700011
gsk690693Homo sapiens (human)Kd10.000011
gdc 0941Homo sapiens (human)Kd10.000011
plx 4720Homo sapiens (human)Kd10.000011
sgx 523Homo sapiens (human)Kd10.000011
quizartinibHomo sapiens (human)Kd10.000022
incb-018424Homo sapiens (human)Kd10.000011
gsk 1838705aHomo sapiens (human)Kd10.000011
gsk 1363089Homo sapiens (human)Kd0.012011
chir 258Homo sapiens (human)Kd10.000022
nintedanibHomo sapiens (human)Kd0.550011
pp242Homo sapiens (human)Kd1.900011

Enables

This protein enables 5 target(s):

TargetCategoryDefinition
transmembrane-ephrin receptor activitymolecular functionCombining with a transmembrane ephrin to initiate a change in cell activity. [GOC:mah, PMID:9530499]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
ATP bindingmolecular functionBinding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
axon guidance receptor activitymolecular functionCombining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance. [GOC:dph, GOC:signaling, GOC:tb, PMID:15107857, PMID:15339666]
protein-containing complex bindingmolecular functionBinding to a macromolecular complex. [GOC:jl]

Located In

This protein is located in 10 target(s):

TargetCategoryDefinition
extracellular regioncellular componentThe space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
endoplasmic reticulumcellular componentThe irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
axoncellular componentThe long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. [GOC:nln, ISBN:0198506732]
early endosome membranecellular componentThe lipid bilayer surrounding an early endosome. [GOC:pz]
filopodium tipcellular componentThe end of a filopodium distal to the body of the cell. [GOC:mah]
membrane raftcellular componentAny of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. [PMID:16645198, PMID:20044567]
extracellular exosomecellular componentA vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
glutamatergic synapsecellular componentA synapse that uses glutamate as a neurotransmitter. [GOC:dos]

Active In

This protein is active in 2 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
dendritecellular componentA neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]

Involved In

This protein is involved in 26 target(s):

TargetCategoryDefinition
angiogenesisbiological processBlood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453]
immunological synapse formationbiological processThe formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. [GOC:mgi_curators, PMID:11244041, PMID:11376330]
axon guidancebiological processThe chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. [ISBN:0878932437]
skeletal muscle satellite cell activationbiological processThe change of a skeletal muscle satellite cell from a mitotically quiescent to a mitotically active state following exposure to some activating factor such as a cellular or soluble ligand. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage. [GOC:mtg_muscle, PMID:23303905]
optic nerve morphogenesisbiological processThe process in which the anatomical structure of the optic nerve is generated and organized. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
hindbrain tangential cell migrationbiological processThe migration of a cell in the hindbrain in which cells move orthogonal to the direction of radial migration. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
central nervous system projection neuron axonogenesisbiological processGeneration of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
neurogenesisbiological processGeneration of cells within the nervous system. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
establishment of cell polaritybiological processThe specification and formation of anisotropic intracellular organization or cell growth patterns. [GOC:mah]
retinal ganglion cell axon guidancebiological processThe process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues. [GOC:ejs]
cell-substrate adhesionbiological processThe attachment of a cell to the underlying substrate via adhesion molecules. [GOC:mah, GOC:pf]
regulation of JNK cascadebiological processAny process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade. [GOC:bf]
protein autophosphorylationbiological processThe phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). [ISBN:0198506732]
ephrin receptor signaling pathwaybiological processThe series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb]
camera-type eye morphogenesisbiological processThe process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. [GOC:jid, GOC:mtg_sensu]
modulation of chemical synaptic transmissionbiological processAny process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission. [GOC:ai]
detection of temperature stimulus involved in sensory perception of painbiological processThe series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos]
positive regulation of synapse assemblybiological processAny process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. [GOC:ai, GOC:pr]
cell chemotaxisbiological processThe directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [GOC:dph]
dendritic spine developmentbiological processThe process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. [GOC:dph]
dendritic spine morphogenesisbiological processThe process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. [GOC:dph]
neural precursor cell proliferationbiological processThe multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell. [GOC:dph, GOC:yaf]
regulation of ERK1 and ERK2 cascadebiological processAny process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:add, ISBN:0121245462, ISBN:0896039986]
negative regulation of skeletal muscle satellite cell proliferationbiological processAny process that stops, prevents or reduces the frequency, rate or extent of satellite cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:23212449]
negative regulation of satellite cell differentiationbiological processAny process that stops, prevents or reduces the frequency, rate or extent of satellite cell differentiation. [GO_REF:0000058, GOC:TermGenie, PMID:23212449]
protein phosphorylationbiological processThe process of introducing a phosphate group on to a protein. [GOC:hb]