Proteins > Corticotropin-releasing factor receptor 1
Page last updated: 2024-08-07 16:32:36

Corticotropin-releasing factor receptor 1

A corticotropin-releasing factor receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34998]

Synonyms

CRF-R-1;
CRF-R1;
CRFR-1;
Corticotropin-releasing hormone receptor 1;
CRH-R-1;
CRH-R1

Research

Bioassay Publications (44)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's7 (15.91)18.2507
2000's20 (45.45)29.6817
2010's17 (38.64)24.3611
2020's0 (0.00)2.80

Compounds (15)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
hypericinHomo sapiens (human)IC500.300022
nbi 27914Homo sapiens (human)Ki0.006578
antalarminHomo sapiens (human)IC500.018622
antalarminHomo sapiens (human)Ki0.008355
ssr 125543aHomo sapiens (human)Ki0.240011
cp 154526Homo sapiens (human)IC500.013422
cp 154526Homo sapiens (human)Ki0.00731112
ucb 35625Homo sapiens (human)IC505.000422
r 121919Homo sapiens (human)IC500.032177
r 121919Homo sapiens (human)Ki0.00521010
pexacerfontHomo sapiens (human)IC502.587644
4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)pyrimidineHomo sapiens (human)IC500.010011
4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)pyrimidineHomo sapiens (human)Ki0.001144
nbi-34041Homo sapiens (human)Ki0.004533
dmp 696Homo sapiens (human)IC500.050444
dmp 696Homo sapiens (human)Ki0.001844
cp 154526Homo sapiens (human)Ki0.002222
gsk 561679Homo sapiens (human)IC500.100011
gsk 561679Homo sapiens (human)Ki0.006311
bms 665053Homo sapiens (human)IC500.004911
nitd 609Homo sapiens (human)IC5030.000011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
r 121919Homo sapiens (human)Kd0.000311
4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)pyrimidineHomo sapiens (human)Kd0.000311

Enables

This protein enables 5 target(s):

TargetCategoryDefinition
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
corticotrophin-releasing factor receptor activitymolecular functionCombining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity. [PMID:12032352]
G protein-coupled peptide receptor activitymolecular functionCombining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:dph, GOC:tb]
corticotropin-releasing hormone bindingmolecular functionBinding to corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland. [PMID:7556876]
corticotropin-releasing hormone receptor activitymolecular functionCombining with corticotropin-releasing hormone and transmitting the signal to initiate a change in cell activity. [GOC:signaling, ISBN:0838577016, PMID:11027914, PMID:15134857]

Located In

This protein is located in 3 target(s):

TargetCategoryDefinition
endosomecellular componentA vacuole to which materials ingested by endocytosis are delivered. [ISBN:0198506732, PMID:19696797]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

Active In

This protein is active in 2 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
neuron projectioncellular componentA prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]

Involved In

This protein is involved in 16 target(s):

TargetCategoryDefinition
immune responsebiological processAny immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. [GO_REF:0000022, GOC:add]
cell surface receptor signaling pathwaybiological processThe series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:signaling]
adenylate cyclase-activating G protein-coupled receptor signaling pathwaybiological processA G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
activation of adenylate cyclase activitybiological processAny process that initiates the activity of the inactive enzyme adenylate cyclase. [GOC:ai]
female pregnancybiological processThe set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth. [ISBN:0192800825]
parturitionbiological processThe reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs. [ISBN:0198506732]
regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathwaybiological processAny process that modulates the frequency, rate or extent of adenylate cyclase (AC) activity that is an integral part of a G protein-coupled receptor signaling pathway. [GOC:dph, GOC:signaling, GOC:tb]
adrenal gland developmentbiological processThe process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells. [GOC:dgh]
exploration behaviorbiological processThe specific behavior of an organism in response to a novel environment or stimulus. [GOC:BHF, GOC:pr, PMID:11682103, PMID:9767169]
fear responsebiological processThe response of an organism to a perceived external threat. [GOC:go_curators]
behavioral response to ethanolbiological processAny process that results in a change in the behavior of an organism as a result of an ethanol stimulus. [GOC:jid]
corticotropin secretionbiological processThe regulated release of corticotropin by a cell. Corticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus. [GOC:cjm, PMID:11027914]
general adaptation syndrome, behavioral processbiological processThe set of behavioral processes that occur as part of the general adaptation syndrome, the response of the body to a strong, stressful stimulus. [GOC:ai]
cellular response to corticotropin-releasing hormone stimulusbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response. [GOC:mah]
negative regulation of voltage-gated calcium channel activitybiological processAny process that stops, prevents or reduces the frequency, rate or extent of voltage-gated calcium channel activity. [GOC:BHF, GOC:TermGenie]
regulation of corticosterone secretionbiological processAny process that modulates the frequency, rate or extent of corticosterone secretion. [GOC:sl]