5-hydroxytryptamine receptor 2C

A 5-hydroxytryptamine receptor 2C that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28335]

Synonyms

5-HT-2C;
5-HT2C;
5-HTR2C;
5-hydroxytryptamine receptor 1C;
5-HT-1C;
5-HT1C;
Serotonin receptor 2C

Research

Bioassay Publications (192)

Compounds (251)

Drugs with Inhibition Measurements

Drugs with Activation Measurements

Drugs with Other Measurements

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	2 (1.04)	18.7374
1990's	22 (11.46)	18.2507
2000's	74 (38.54)	29.6817
2010's	78 (40.63)	24.3611
2020's	16 (8.33)	2.80

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
tryptamine	Homo sapiens (human)	Ki	0.0500	1	1
8-hydroxy-2-(di-n-propylamino)tetralin	Homo sapiens (human)	Ki	11.0250	2	2
4-iodo-2,5-dimethoxyphenylisopropylamine	Homo sapiens (human)	Ki	0.0018	1	1
octoclothepine	Homo sapiens (human)	Ki	0.0006	1	1
1-(3-chlorophenyl)piperazine	Homo sapiens (human)	Ki	0.0146	6	6
4-nonylphenol	Homo sapiens (human)	IC50	2.5710	1	0
4-nonylphenol	Homo sapiens (human)	Ki	1.3470	1	0
5-carboxamidotryptamine	Homo sapiens (human)	Ki	1.5659	2	2
methylbufotenin	Homo sapiens (human)	IC50	0.2500	1	1
methylbufotenin	Homo sapiens (human)	Ki	0.0420	1	1
5-methoxytryptamine	Homo sapiens (human)	Ki	0.0450	1	1
alpha-methylserotonin	Homo sapiens (human)	Ki	0.0245	3	3
amiodarone	Homo sapiens (human)	IC50	0.4040	1	0
amiodarone	Homo sapiens (human)	Ki	0.2120	1	0
amitriptyline	Homo sapiens (human)	IC50	0.0060	1	0
amitriptyline	Homo sapiens (human)	Ki	0.0032	1	0
amoxapine	Homo sapiens (human)	IC50	0.0038	1	0
amoxapine	Homo sapiens (human)	Ki	0.0020	1	0
astemizole	Homo sapiens (human)	IC50	0.1790	1	0
astemizole	Homo sapiens (human)	Ki	0.0940	1	0
azelastine	Homo sapiens (human)	Ki	0.5012	1	1
bithionol	Homo sapiens (human)	IC50	8.7800	1	0
bithionol	Homo sapiens (human)	Ki	4.5990	1	0
buspirone	Homo sapiens (human)	Ki	2.2700	1	1
verapamil	Homo sapiens (human)	IC50	0.2970	1	0
verapamil	Homo sapiens (human)	Ki	0.1550	1	0
carvedilol	Homo sapiens (human)	IC50	0.1150	1	0
carvedilol	Homo sapiens (human)	Ki	0.0600	1	0
cgs 12066	Homo sapiens (human)	IC50	68.4825	3	3
chlorpromazine	Homo sapiens (human)	IC50	0.0052	1	0
chlorpromazine	Homo sapiens (human)	Ki	0.0260	4	4
cisapride	Homo sapiens (human)	IC50	0.2597	3	2
cisapride	Homo sapiens (human)	Ki	0.4020	1	0
citalopram	Homo sapiens (human)	IC50	0.2970	1	0
citalopram	Homo sapiens (human)	Ki	0.1560	1	0
clomipramine	Homo sapiens (human)	IC50	0.0340	1	0
clomipramine	Homo sapiens (human)	Ki	0.0180	1	0
clotrimazole	Homo sapiens (human)	IC50	14.4720	1	0
clotrimazole	Homo sapiens (human)	Ki	7.5810	1	0
cyproheptadine	Homo sapiens (human)	IC50	0.0024	1	0
cyproheptadine	Homo sapiens (human)	Ki	0.0061	2	1
dicyclomine	Homo sapiens (human)	IC50	0.4680	1	0
dicyclomine	Homo sapiens (human)	Ki	0.2450	1	0
diphenhydramine	Homo sapiens (human)	IC50	0.9800	1	0
diphenhydramine	Homo sapiens (human)	Ki	0.5130	1	0
domperidone	Homo sapiens (human)	IC50	1.3320	1	0
domperidone	Homo sapiens (human)	Ki	0.6980	1	0
doxazosin	Homo sapiens (human)	IC50	0.5440	1	0
doxazosin	Homo sapiens (human)	Ki	0.2850	1	0
doxepin	Homo sapiens (human)	IC50	0.0460	1	0
doxepin	Homo sapiens (human)	Ki	0.0240	1	0
droperidol	Homo sapiens (human)	IC50	0.4540	1	0
droperidol	Homo sapiens (human)	Ki	0.2380	1	0
ebastine	Homo sapiens (human)	IC50	0.2375	1	0
ebastine	Homo sapiens (human)	Ki	0.1244	1	0
econazole	Homo sapiens (human)	IC50	11.9820	1	0
econazole	Homo sapiens (human)	Ki	6.2760	1	0
fenofibrate	Homo sapiens (human)	IC50	2.3710	1	0
fenofibrate	Homo sapiens (human)	Ki	1.2420	1	0
fluphenazine	Homo sapiens (human)	IC50	0.0670	1	0
fluphenazine	Homo sapiens (human)	Ki	0.0350	1	0
fluoxetine	Homo sapiens (human)	IC50	0.1395	2	1
fluoxetine	Homo sapiens (human)	Ki	0.0620	1	0
guanfacine	Homo sapiens (human)	IC50	1.4530	1	0
guanfacine	Homo sapiens (human)	Ki	0.7610	1	0
haloperidol	Homo sapiens (human)	IC50	6.6735	2	1
haloperidol	Homo sapiens (human)	Ki	4.7367	11	10
haloprogin	Homo sapiens (human)	IC50	2.6020	1	0
haloprogin	Homo sapiens (human)	Ki	1.3630	1	0
hexachlorophene	Homo sapiens (human)	IC50	4.6042	1	0
hexachlorophene	Homo sapiens (human)	Ki	2.4117	1	0
imipramine	Homo sapiens (human)	Ki	0.1600	1	1
ketanserin	Homo sapiens (human)	IC50	0.0027	1	1
ketanserin	Homo sapiens (human)	Ki	0.0718	2	2
ketotifen	Homo sapiens (human)	IC50	0.1600	1	0
ketotifen	Homo sapiens (human)	Ki	0.1418	2	1
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one	Homo sapiens (human)	IC50	1.0020	1	0
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one	Homo sapiens (human)	Ki	0.5250	1	0
maprotiline	Homo sapiens (human)	IC50	0.0780	1	0
maprotiline	Homo sapiens (human)	Ki	0.0410	1	0
mescaline	Homo sapiens (human)	Ki	0.3028	1	1
methapyrilene	Homo sapiens (human)	IC50	0.7440	1	0
methapyrilene	Homo sapiens (human)	Ki	0.3900	1	0
metoclopramide	Homo sapiens (human)	IC50	2.3830	1	0
metoclopramide	Homo sapiens (human)	Ki	1.2480	1	0
mianserin	Homo sapiens (human)	IC50	0.0043	2	1
mianserin	Homo sapiens (human)	Ki	0.0048	6	7
miconazole	Homo sapiens (human)	IC50	5.3140	1	0
miconazole	Homo sapiens (human)	Ki	2.7840	1	0
mirtazapine	Homo sapiens (human)	Ki	0.0390	1	1
mitoxantrone	Homo sapiens (human)	IC50	3.5619	1	0
mitoxantrone	Homo sapiens (human)	Ki	1.8657	1	0
1-(3-trifluoromethylphenyl)piperazine	Homo sapiens (human)	IC50	0.1500	1	1
nifedipine	Homo sapiens (human)	IC50	18.2730	1	0
nifedipine	Homo sapiens (human)	Ki	9.5720	1	0
nortriptyline	Homo sapiens (human)	IC50	0.0160	1	0
nortriptyline	Homo sapiens (human)	Ki	0.0082	1	0
orphenadrine	Homo sapiens (human)	IC50	0.5340	1	0
orphenadrine	Homo sapiens (human)	Ki	0.2800	1	0
oxymetazoline	Homo sapiens (human)	IC50	0.5780	1	0
oxymetazoline	Homo sapiens (human)	Ki	0.3030	1	0
pentamidine	Homo sapiens (human)	IC50	3.2780	1	0
pentamidine	Homo sapiens (human)	Ki	1.7170	1	0
pindolol	Homo sapiens (human)	Ki	54.0000	1	1
pirenperone	Homo sapiens (human)	Ki	0.0600	1	1
prochlorperazine	Homo sapiens (human)	IC50	0.0780	1	0
prochlorperazine	Homo sapiens (human)	Ki	0.0410	1	0
promazine	Homo sapiens (human)	IC50	0.0990	1	0
promazine	Homo sapiens (human)	Ki	0.0520	1	0
promethazine	Homo sapiens (human)	IC50	0.0120	1	0
promethazine	Homo sapiens (human)	Ki	0.0065	1	0
propafenone	Homo sapiens (human)	IC50	0.3840	1	0
propafenone	Homo sapiens (human)	Ki	0.2010	1	0
propofol	Homo sapiens (human)	IC50	11.5530	1	0
propofol	Homo sapiens (human)	Ki	6.0510	1	0
propranolol	Homo sapiens (human)	IC50	3.6529	2	1
propranolol	Homo sapiens (human)	Ki	1.2020	1	0
psilocin	Homo sapiens (human)	IC50	0.0078	1	1
pyrilamine	Homo sapiens (human)	IC50	1.1300	1	0
pyrilamine	Homo sapiens (human)	Ki	0.5920	1	0
quetiapine	Homo sapiens (human)	IC50	3.3008	1	0
quetiapine	Homo sapiens (human)	Ki	1.7338	5	4
quipazine	Homo sapiens (human)	IC50	0.0617	2	2
quipazine	Homo sapiens (human)	Ki	0.2000	1	1
raloxifene	Homo sapiens (human)	IC50	1.1780	1	0
raloxifene	Homo sapiens (human)	Ki	0.6170	1	0
risperidone	Homo sapiens (human)	IC50	0.0057	6	5
risperidone	Homo sapiens (human)	Ki	0.0271	16	15
ritanserin	Homo sapiens (human)	IC50	0.0025	1	3
ritanserin	Homo sapiens (human)	Ki	0.0009	6	7
rizatriptan	Homo sapiens (human)	IC50	8.9716	2	2
sb 206553	Homo sapiens (human)	IC50	0.0094	1	1
sb 206553	Homo sapiens (human)	Ki	0.0095	4	4
spiperone	Homo sapiens (human)	Ki	1.1500	1	1
sulconazole	Homo sapiens (human)	IC50	2.7850	1	0
sulconazole	Homo sapiens (human)	Ki	1.4590	1	0
sumatriptan	Homo sapiens (human)	IC50	5.9835	3	3
terfenadine	Homo sapiens (human)	IC50	1.2310	1	0
terfenadine	Homo sapiens (human)	Ki	0.6450	1	0
tetracaine	Homo sapiens (human)	IC50	3.2680	1	0
tetracaine	Homo sapiens (human)	Ki	1.7120	1	0
thioridazine	Homo sapiens (human)	IC50	0.0440	1	0
thioridazine	Homo sapiens (human)	Ki	0.0230	1	0
trazodone	Homo sapiens (human)	IC50	0.0910	1	0
trazodone	Homo sapiens (human)	Ki	0.0470	1	0
trioxsalen	Homo sapiens (human)	IC50	2.3560	1	0
trioxsalen	Homo sapiens (human)	Ki	1.2340	1	0
zotepine	Homo sapiens (human)	Ki	0.0029	1	1
lysergic acid diethylamide	Homo sapiens (human)	Ki	0.0050	1	1
phentolamine	Homo sapiens (human)	IC50	0.3960	1	0
phentolamine	Homo sapiens (human)	Ki	0.2070	1	0
2-acetylaminofluorene	Homo sapiens (human)	IC50	2.1430	1	0
2-acetylaminofluorene	Homo sapiens (human)	Ki	1.1220	1	0
mepazine	Homo sapiens (human)	IC50	0.4950	1	0
mepazine	Homo sapiens (human)	Ki	0.2590	1	0
n,n-dimethyltryptamine	Homo sapiens (human)	Ki	0.0330	1	1
cyclizine	Homo sapiens (human)	IC50	1.0210	1	0
cyclizine	Homo sapiens (human)	Ki	0.5350	1	0
phenothiazine	Homo sapiens (human)	IC50	2.2360	1	0
phenothiazine	Homo sapiens (human)	Ki	1.1710	1	0
ergotamine	Homo sapiens (human)	IC50	0.0560	1	0
ergotamine	Homo sapiens (human)	Ki	0.0290	1	0
methylergonovine	Homo sapiens (human)	IC50	0.0130	1	0
methylergonovine	Homo sapiens (human)	Ki	0.0066	1	0
benzethonium chloride	Homo sapiens (human)	IC50	1.0270	1	0
benzethonium chloride	Homo sapiens (human)	Ki	0.5380	1	0
sterogenol	Homo sapiens (human)	IC50	1.2880	1	0
sterogenol	Homo sapiens (human)	Ki	0.6740	1	0
indopan	Homo sapiens (human)	Ki	0.1660	1	2
methysergide	Homo sapiens (human)	IC50	0.0021	1	0
methysergide	Homo sapiens (human)	Ki	0.0018	2	1
bufotenin	Homo sapiens (human)	Ki	0.0700	1	1
dihydroergotamine	Homo sapiens (human)	IC50	0.0900	1	0
dihydroergotamine	Homo sapiens (human)	Ki	0.0470	1	0
dimenhydrinate	Homo sapiens (human)	IC50	0.6340	1	0
dimenhydrinate	Homo sapiens (human)	Ki	0.3320	1	0
5-fluoro-alpha-methyltryptamine	Homo sapiens (human)	Ki	0.0100	1	1
azaperone	Homo sapiens (human)	Ki	1.4446	2	4
n-methyllaurotetanine	Homo sapiens (human)	Ki	0.9500	1	1
glaucine	Homo sapiens (human)	Ki	0.3280	1	1
clemastine	Homo sapiens (human)	IC50	0.0990	1	0
clemastine	Homo sapiens (human)	Ki	0.0520	1	0
pizotyline	Homo sapiens (human)	Ki	0.0014	1	1
metergoline	Homo sapiens (human)	IC50	0.0007	1	0
metergoline	Homo sapiens (human)	Ki	0.0004	2	1
lisuride	Homo sapiens (human)	IC50	0.0200	1	0
lisuride	Homo sapiens (human)	Ki	0.0100	1	0
bromocriptine	Homo sapiens (human)	IC50	0.5320	1	0
bromocriptine	Homo sapiens (human)	Ki	0.2780	1	0
dexchlorpheniramine	Homo sapiens (human)	IC50	2.3220	1	0
dexchlorpheniramine	Homo sapiens (human)	Ki	1.2170	1	0
penfluridol	Homo sapiens (human)	Ki	0.8810	1	1
5-methoxy-alpha-methyltryptamine	Homo sapiens (human)	Ki	0.0083	2	2
pergolide	Homo sapiens (human)	IC50	0.3790	1	0
pergolide	Homo sapiens (human)	Ki	0.1990	1	0
sertindole	Homo sapiens (human)	Ki	0.0008	3	3
fananserin	Homo sapiens (human)	Ki	0.0010	1	1
aripiprazole	Homo sapiens (human)	IC50	1.3800	3	3
aripiprazole	Homo sapiens (human)	Ki	0.0829	7	8
ziprasidone	Homo sapiens (human)	Ki	0.0050	6	6
fluoxetine hydrochloride	Homo sapiens (human)	Ki	0.0720	1	1
sertraline	Homo sapiens (human)	IC50	1.0830	1	0
sertraline	Homo sapiens (human)	Ki	0.5673	1	0
mesulergine	Homo sapiens (human)	IC50	0.0019	1	1
mesulergine	Homo sapiens (human)	Ki	0.0014	3	3
mdl 11939	Homo sapiens (human)	Ki	10.0000	1	1
ergocornine	Homo sapiens (human)	IC50	0.1040	1	0
ergocornine	Homo sapiens (human)	Ki	0.0550	1	0
s20098	Homo sapiens (human)	Ki	0.6820	3	3
u 74006f	Homo sapiens (human)	IC50	0.7180	1	0
u 74006f	Homo sapiens (human)	Ki	0.3760	1	0
gr 127935	Homo sapiens (human)	Ki	0.1050	1	1
6-chloro-2-(1-piperazinyl)pyrazine	Homo sapiens (human)	Ki	3.3942	1	2
5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole	Homo sapiens (human)	IC50	0.2950	2	2
5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1h indole	Homo sapiens (human)	Ki	0.4000	1	1
mosapride	Homo sapiens (human)	IC50	0.3966	1	0
mosapride	Homo sapiens (human)	Ki	0.2077	1	0
sb 204070a	Homo sapiens (human)	Ki	0.1027	2	2
n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine	Homo sapiens (human)	Ki	5.4200	2	2
cp 93129	Homo sapiens (human)	IC50	6.4000	1	1
desloratadine	Homo sapiens (human)	IC50	0.0300	1	0
desloratadine	Homo sapiens (human)	Ki	0.0160	1	0
l 694247	Homo sapiens (human)	IC50	0.3162	1	1
sc 53116	Homo sapiens (human)	IC50	10.0000	1	1
sc 53116	Homo sapiens (human)	Ki	10.0000	1	1
l 741626	Homo sapiens (human)	Ki	6.5700	1	1
alpha-ergocryptine	Homo sapiens (human)	IC50	0.1470	1	0
alpha-ergocryptine	Homo sapiens (human)	Ki	0.0770	1	0
n-methylserotonin	Homo sapiens (human)	Ki	0.2800	1	1
6-hydroxytryptamine	Homo sapiens (human)	Ki	5.5000	1	1
harmalan	Homo sapiens (human)	Ki	1.8600	1	1
n-demethyllysergic acid diethylamide	Homo sapiens (human)	IC50	1.2900	1	1
5,6,7,8-tetrahydro-4h-isoxazolo(4,5-d)azepin-3-ol	Homo sapiens (human)	Ki	308.1140	1	2
atropine	Homo sapiens (human)	IC50	1.0120	1	0
atropine	Homo sapiens (human)	Ki	0.5300	1	0
nantenine, (+-)-isomer	Homo sapiens (human)	Ki	1.0690	1	1
maduramicin	Homo sapiens (human)	IC50	0.0340	1	0
maduramicin	Homo sapiens (human)	Ki	0.0180	1	0
latrepirdine	Homo sapiens (human)	Ki	0.0759	2	2
sorafenib	Homo sapiens (human)	Ki	0.4170	1	1
1-methyl-6-methoxy-dihydro-beta-carboline	Homo sapiens (human)	Ki	0.9240	1	1
terconazole	Homo sapiens (human)	IC50	6.9610	1	0
terconazole	Homo sapiens (human)	Ki	3.6460	1	0
sb 221284	Homo sapiens (human)	Ki	0.0025	2	2
sb 228357	Homo sapiens (human)	IC50	0.0100	1	1
sb 228357	Homo sapiens (human)	Ki	0.0010	1	1
sb 243213	Homo sapiens (human)	IC50	0.0007	1	1
sb 243213	Homo sapiens (human)	Ki	0.0010	4	4
ergonovine	Homo sapiens (human)	IC50	0.0210	1	0
ergonovine	Homo sapiens (human)	Ki	0.0110	1	0
dihydroergocristine monomesylate	Homo sapiens (human)	IC50	0.2390	1	0
dihydroergocristine monomesylate	Homo sapiens (human)	Ki	0.1250	1	0
diethylstilbestrol	Homo sapiens (human)	IC50	50.8190	1	0
diethylstilbestrol	Homo sapiens (human)	Ki	26.6190	1	0
cannabidiol	Homo sapiens (human)	Ki	1.1000	1	1
3,4,5-trimethoxycinnamic acid	Homo sapiens (human)	IC50	2.5000	2	2
flunarizine	Homo sapiens (human)	IC50	0.6690	1	0
flunarizine	Homo sapiens (human)	Ki	0.3510	1	0
benztropine	Homo sapiens (human)	IC50	0.0610	1	0
benztropine	Homo sapiens (human)	Ki	0.0320	1	0
enclomiphene	Homo sapiens (human)	IC50	1.2720	1	0
enclomiphene	Homo sapiens (human)	Ki	0.6660	1	0
4-phenyl-1,2,3,6-tetrahydropyridine hdyrochloride	Homo sapiens (human)	Ki	7.1800	1	1
tamoxifen	Homo sapiens (human)	IC50	0.4600	1	0
tamoxifen	Homo sapiens (human)	Ki	0.2410	1	0
dapiprazole	Homo sapiens (human)	IC50	0.6250	1	0
dapiprazole	Homo sapiens (human)	Ki	0.3270	1	0
altanserin	Homo sapiens (human)	Ki	0.0400	1	1
mitragynine	Homo sapiens (human)	Ki	10.0000	1	1
2-chloro-n(6)-(3-iodobenzyl)adenosine-5'-n-methyluronamide	Homo sapiens (human)	Ki	10.0000	1	1
paynantheine	Homo sapiens (human)	Ki	1.7700	1	1
bp 897	Homo sapiens (human)	Ki	0.8400	2	2
ym348	Homo sapiens (human)	Ki	0.0009	2	2
ro 60-0175	Homo sapiens (human)	Ki	0.0080	4	4
sb-224289	Homo sapiens (human)	Ki	0.6310	1	1
sb 242084	Homo sapiens (human)	IC50	0.0003	1	1
sb 242084	Homo sapiens (human)	Ki	0.0010	4	4
rs 102221	Homo sapiens (human)	IC50	0.0039	5	5
rs 102221	Homo sapiens (human)	Ki	0.0015	4	4
bw 723c86	Homo sapiens (human)	IC50	0.2043	1	0
bw 723c86	Homo sapiens (human)	Ki	0.1070	1	0
harmine	Homo sapiens (human)	Ki	9.3400	1	1
genistein	Homo sapiens (human)	IC50	14.9100	1	0
genistein	Homo sapiens (human)	Ki	7.8060	1	0
methysergide maleate	Homo sapiens (human)	Ki	0.0008	1	1
amentoflavone	Homo sapiens (human)	Ki	2.5550	1	1
ly 344864	Homo sapiens (human)	Ki	0.5000	1	1
l 745870	Homo sapiens (human)	Ki	3.7333	3	3
mdl 100907	Homo sapiens (human)	Ki	0.0924	5	5
sb 200646a	Homo sapiens (human)	Ki	0.1238	2	2
sb 258719	Homo sapiens (human)	Ki	15.8489	1	1
sb 271046	Homo sapiens (human)	Ki	1.0179	3	4
cinanserin	Homo sapiens (human)	Ki	0.2000	1	1
guanabenz	Homo sapiens (human)	IC50	0.2040	1	0
guanabenz	Homo sapiens (human)	Ki	0.1070	1	0
1-(3-(5-(1,2,4-triazol-4-yl)-1h-indol-3-yl)propyl)-4-(2-(3-fluorophenyl)ethyl)piperazine	Homo sapiens (human)	IC50	9.0000	1	1
sb 269970	Homo sapiens (human)	Ki	6.6683	3	3
sb 334867-a	Homo sapiens (human)	Ki	3.1059	2	2
2-ethyl-5-methoxy-n,n-dimethyltryptamine	Homo sapiens (human)	IC50	5.5000	1	1
n-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide	Homo sapiens (human)	Ki	5.0119	1	1
4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine	Homo sapiens (human)	Ki	10.0000	1	1
rwj 68354	Homo sapiens (human)	IC50	1.2370	1	0
rwj 68354	Homo sapiens (human)	Ki	0.6480	1	0
n-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide	Homo sapiens (human)	Ki	0.0527	1	1
4-iodo-2,5-dimethoxyphenylisopropylamine, (r)-isomer	Homo sapiens (human)	Ki	0.0040	2	2
s 21007	Homo sapiens (human)	IC50	1.8621	2	2
sb258741	Homo sapiens (human)	Ki	5.0119	1	1
fauc 346	Homo sapiens (human)	Ki	0.3500	1	1
ngb 2904	Homo sapiens (human)	Ki	0.4110	1	1
2-(3-chlorobenzyloxy)-6-(piperazin-1-yl)pyrazine	Homo sapiens (human)	Ki	0.0065	2	3
4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl)-1-(4-fluorophenyl)butan-1-one	Homo sapiens (human)	Ki	2.4250	2	4
4-n-butyl-1-(4-(2-methylphenyl)-4-oxo-1-butyl)-piperidine hydrogen chloride	Homo sapiens (human)	Ki	1.0000	1	1
1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene	Homo sapiens (human)	Ki	0.4300	1	1
sb-656104-a	Homo sapiens (human)	Ki	0.2692	1	1
pimavanserin	Homo sapiens (human)	IC50	0.0464	1	2
pimavanserin	Homo sapiens (human)	Ki	0.0012	2	3
tert-butyl peroxybenzoate	Homo sapiens (human)	Ki	0.0850	1	1
way 163909	Homo sapiens (human)	Ki	0.0102	2	2
5-chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1h-indole	Homo sapiens (human)	IC50	0.4500	1	1
way 181187	Homo sapiens (human)	Ki	0.3463	2	4
2-(4-iodo-2,5-dimethoxyphenyl)-n-(2-methoxybenzyl)ethanamine	Homo sapiens (human)	Ki	0.0070	1	1
fauc 365	Homo sapiens (human)	Ki	2.0000	1	1
sb-649915	Homo sapiens (human)	Ki	7.9433	1	1
way-208466	Homo sapiens (human)	IC50	0.6440	1	1
9-(aminomethyl)-9,10-dihydroanthracene	Homo sapiens (human)	Ki	0.0430	1	1
meridianin a	Homo sapiens (human)	Ki	10.0000	1	1
1-(2,4-difluorophenethyl)-4-(4-fluorophenylsulfonyl)piperidine	Homo sapiens (human)	Ki	0.0788	4	4
cariprazine	Homo sapiens (human)	Ki	0.1989	1	2
barettin	Homo sapiens (human)	Ki	0.3400	1	1
naphyrone	Homo sapiens (human)	IC50	10.0000	1	1
naluzotan	Homo sapiens (human)	Ki	5.0000	1	1
pg 01037	Homo sapiens (human)	Ki	0.0470	1	1
vabicaserin	Homo sapiens (human)	Ki	0.0030	1	1
col-144	Homo sapiens (human)	Ki	0.5940	1	1
lassbio-579	Homo sapiens (human)	Ki	8.5350	2	2
lorcaserin	Homo sapiens (human)	Ki	0.0713	7	7
td-5108	Homo sapiens (human)	Ki	0.1000	1	1
octoclothepine, (s)-isomer	Homo sapiens (human)	Ki	0.0029	1	1
mitragynine	Homo sapiens (human)	Ki	5.4300	1	1
a 803467	Homo sapiens (human)	IC50	10.0000	1	1
sp 203	Homo sapiens (human)	Ki	10.0000	1	1
lu ae58054	Homo sapiens (human)	Ki	0.2506	1	2
yil 781	Homo sapiens (human)	Ki	1.0000	1	1
pf 04457845	Homo sapiens (human)	Ki	1.6594	1	0
pf 3246799	Homo sapiens (human)	Ki	0.1700	2	2
nitd 609	Homo sapiens (human)	IC50	10.0000	1	1
n,n-diallyl-5-methoxytryptamine	Homo sapiens (human)	Ki	3.4837	2	4
clozapine	Homo sapiens (human)	IC50	0.0658	3	4
clozapine	Homo sapiens (human)	Ki	0.0154	23	25
olanzapine	Homo sapiens (human)	IC50	0.0210	1	0
olanzapine	Homo sapiens (human)	Ki	0.0083	9	8
tegaserod	Homo sapiens (human)	Ki	0.1000	1	1
methylaplysinopsin	Homo sapiens (human)	Ki	10.0000	1	1
aplysinopsin	Homo sapiens (human)	Ki	12.2255	2	2

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
4-iodo-2,5-dimethoxyphenylisopropylamine	Homo sapiens (human)	EC50	0.0457	1	1
1-(3-chlorophenyl)piperazine	Homo sapiens (human)	EC50	0.0466	10	10
methylbufotenin	Homo sapiens (human)	Kd	0.0794	1	1
methiothepin	Homo sapiens (human)	EC50	0.0004	1	1
propranolol	Homo sapiens (human)	EC50	5.0119	1	1
psilocin	Homo sapiens (human)	EC50	0.0300	1	1
mecoprop	Homo sapiens (human)	EC50	0.1200	1	1
indopan	Homo sapiens (human)	EC50	0.1071	1	2
psilocybin	Homo sapiens (human)	EC50	0.5060	1	1
lisuride	Homo sapiens (human)	EC50	0.0246	1	0
bromocriptine	Homo sapiens (human)	EC50	1.5849	1	0
pergolide	Homo sapiens (human)	EC50	0.2188	1	0
6-chloro-2-(1-piperazinyl)pyrazine	Homo sapiens (human)	EC50	0.0946	2	4
Serotonin hydrochloride	Homo sapiens (human)	EC50	0.0003	1	2
5,6,7,8-tetrahydro-4h-isoxazolo(4,5-d)azepin-3-ol	Homo sapiens (human)	EC50	1,000.0000	1	2
5-hydroxytryptophan	Homo sapiens (human)	EC50	0.0002	1	2
4-phenyl-1,2,3,6-tetrahydropyridine hdyrochloride	Homo sapiens (human)	EC50	2.4500	1	1
ym348	Homo sapiens (human)	EC50	0.0010	1	1
ro 60-0175	Homo sapiens (human)	EC50	0.0230	4	4
norfenfluramine	Homo sapiens (human)	EC50	0.0251	1	1
2-(3-chlorobenzyloxy)-6-(piperazin-1-yl)pyrazine	Homo sapiens (human)	EC50	0.0040	3	5
way 163909	Homo sapiens (human)	EC50	0.0080	2	2
vabicaserin	Homo sapiens (human)	EC50	0.0080	2	2
lorcaserin	Homo sapiens (human)	EC50	0.0222	15	22
pf 3246799	Homo sapiens (human)	EC50	0.0972	4	4
n,n-diallyl-5-methoxytryptamine	Homo sapiens (human)	EC50	0.0094	1	2
clozapine	Homo sapiens (human)	EC50	0.2500	1	0

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ketanserin	Homo sapiens (human)	Kb	0.1120	1	1
lg 100268	Homo sapiens (human)	Synergy	0.0069	1	1
sb 206553	Homo sapiens (human)	Kb	0.0023	1	1
nuciferine	Homo sapiens (human)	Kb	0.0364	1	1
roemerine	Homo sapiens (human)	Kb	0.0151	1	1
nrx 194204	Homo sapiens (human)	Synergy	0.0019	1	1
way 163909	Homo sapiens (human)	K	0.0090	2	2
vabicaserin	Homo sapiens (human)	K	0.0055	2	2

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New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands.
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Central serotonin receptors as targets for drug research.
Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987

Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists.
Bioorganic & medicinal chemistry, , Jul-15, Volume: 23, Issue:14, 2015

A novel (benzodifuranyl)aminoalkane with extremely potent activity at the 5-HT2A receptor.
Journal of medicinal chemistry, , Dec-17, Volume: 41, Issue:26, 1998

Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity for α(1)-adrenoceptors.
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Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT
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The influence of 5-HT(2A) activity on a 5-HT(2C) specific in vivo assay used for early identification of multiple acting SERT and 5-HT(2C) receptor ligands.
Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 26, Issue:3, 2016

Tetrahydroquinoline-based tricyclic amines as potent and selective agonists of the 5-HT
Bioorganic & medicinal chemistry letters, , 12-15, Volume: 26, Issue:24, 2016

Novel pyrimidoazepine analogs as serotonin 5-HT(2A) and 5-HT(2C) receptor ligands for the treatment of obesity.
European journal of medicinal chemistry, , Volume: 63, 2013

Tricyclic dihydroquinazolinones as novel 5-HT2C selective and orally efficacious anti-obesity agents.
Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 20, Issue:3, 2010

Design and synthesis of pyridazinone-based 5-HT(2C) agonists.
Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 19, Issue:19, 2009

Discovery of a novel azepine series of potent and selective 5-HT2C agonists as potential treatments for urinary incontinence.
Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 19, Issue:17, 2009

Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.
Journal of medicinal chemistry, , Jan-24, Volume: 51, Issue:2, 2008

Discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a selective, orally active agonist of the 5-HT(2C) receptor.
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Pyrrolo(iso)quinoline derivatives as 5-HT(2C) receptor agonists.
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Indoline derivatives as 5-HT(2C) receptor agonists.
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A novel ergot alkaloid as a 5-HT(1A) inhibitor produced by Dicyma sp.
Journal of medicinal chemistry, , Nov-20, Volume: 46, Issue:24, 2003

Central serotonin receptors as targets for drug research.
Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987

1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.
Journal of medicinal chemistry, , Jan-12, Volume: 49, Issue:1, 2006

1-(2-Aminoethyl)-3-methyl-8,9-dihydropyrano[3,2-e]indole: a rotationally restricted phenolic analog of the neurotransmitter serotonin and agonist selective for serotonin (5-HT2-type) receptors.
Journal of medicinal chemistry, , Oct-02, Volume: 35, Issue:20, 1992

Serotonin receptor binding affinities of several hallucinogenic phenylalkylamine and N,N-dimethyltryptamine analogues.
Journal of medicinal chemistry, , Volume: 21, Issue:8, 1978

Central serotonin receptors as targets for drug research.
Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987

1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.
Journal of medicinal chemistry, , Jan-12, Volume: 49, Issue:1, 2006

A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole.
Journal of medicinal chemistry, , Sep-11, Volume: 46, Issue:19, 2003

Central serotonin receptors as targets for drug research.
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[no title available]
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Identification of selective 8-(piperidin-4-yloxy)quinoline sulfone and sulfonamide histamine H
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[no title available]
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New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands.
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[no title available]
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Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines.
Journal of medicinal chemistry, , Jun-06, Volume: 40, Issue:12, 1997

Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines.
Journal of medicinal chemistry, , May-10, Volume: 39, Issue:10, 1996

3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.
Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990

The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds.
Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 24, Issue:2, 2014

CNS and antimalarial activity of synthetic meridianin and psammopemmin analogs.
Bioorganic & medicinal chemistry, , Oct-01, Volume: 19, Issue:19, 2011

Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs.
Journal of medicinal chemistry, , Oct-18, Volume: 50, Issue:21, 2007

[no title available]
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Pyrrolizidine esters and amides as 5-HT4 receptor agonists and antagonists.
Journal of medicinal chemistry, , Feb-09, Volume: 49, Issue:3, 2006

Azaadamantane benzamide 5-HT4 agonists: gastrointestinal prokinetic SC-54750.
Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 14, Issue:22, 2004

[no title available]
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[no title available]
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Structural determinants for high 5-HT(2A) receptor affinity of spiro[9,10-dihydroanthracene]-9,3(')-pyrrolidine (SpAMDA).
Bioorganic & medicinal chemistry letters, , May-03, Volume: 14, Issue:9, 2004

[no title available]
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[no title available]
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Evaluation of anti-depressant effects of phthalazinone-based triple-acting small molecules against 5-HT
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[no title available]
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[no title available]
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Synthesis and binding affinity of potential atypical antipsychotics with the tetrahydroquinazolinone motif.
Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 19, Issue:21, 2009

Synthesis, binding affinity, and molecular docking analysis of new benzofuranone derivatives as potential antipsychotics.
Journal of medicinal chemistry, , Oct-09, Volume: 51, Issue:19, 2008

Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.
Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008

Synthesis and binding affinity of new pyrazole and isoxazole derivatives as potential atypical antipsychotics.
Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 17, Issue:17, 2007

Selective optimization of side activities: another way for drug discovery.
Journal of medicinal chemistry, , Mar-11, Volume: 47, Issue:6, 2004

Chemoenzymatic synthesis and binding affinity of novel (R)- and (S)-3-aminomethyl-1-tetralones, potential atypical antipsychotics.
Bioorganic & medicinal chemistry letters, , Feb-09, Volume: 14, Issue:3, 2004

New serotonin 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptor antagonists: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo and heterocycloalkanones.
Journal of medicinal chemistry, , Jan-03, Volume: 45, Issue:1, 2002

Pharmacological evaluation of a diarylmethylene-piperidine derivative: a new potent atypical antipsychotic?
Bioorganic & medicinal chemistry letters, , May-21, Volume: 11, Issue:10, 2001

Conformationally constrained butyrophenones with affinity for dopamine (D(1), D(2), D(4)) and serotonin (5-HT(2A), 5-HT(2B), 5-HT(2C)) receptors: synthesis of aminomethylbenzo[b]furanones and their evaluation as antipsychotics.
Journal of medicinal chemistry, , Nov-30, Volume: 43, Issue:24, 2000

Conformationally constrained butyrophenones with mixed dopaminergic (D(2)) and serotoninergic (5-HT(2A), 5-HT(2C)) affinities: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo- and -thienocycloalkanones as putative atypical an
Journal of medicinal chemistry, , Jul-29, Volume: 42, Issue:15, 1999

Novel benzothiazolin-2-one and benzoxazin-3-one arylpiperazine derivatives with mixed 5HT1A/D2 affinity as potential atypical antipsychotics.
Journal of medicinal chemistry, , Jun-04, Volume: 41, Issue:12, 1998

[no title available]
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[no title available]
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Structural determinants for high 5-HT(2A) receptor affinity of spiro[9,10-dihydroanthracene]-9,3(')-pyrrolidine (SpAMDA).
Bioorganic & medicinal chemistry letters, , May-03, Volume: 14, Issue:9, 2004

Synthesis and evaluation of nuciferine and roemerine enantiomers as 5-HT
MedChemComm, , Mar-01, Volume: 9, Issue:3, 2018

2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
Journal of medicinal chemistry, , Nov-03, Volume: 48, Issue:22, 2005

New serotonin 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptor antagonists: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo and heterocycloalkanones.
Journal of medicinal chemistry, , Jan-03, Volume: 45, Issue:1, 2002

Central serotonin receptors as targets for drug research.
Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987

Design and synthesis of novel RXR-selective modulators with improved pharmacological profile.
Bioorganic & medicinal chemistry letters, , Nov-17, Volume: 13, Issue:22, 2003

[no title available]
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Dihydrobenzofuran analogues of hallucinogens. 4. Mescaline derivatives.
Journal of medicinal chemistry, , Sep-12, Volume: 40, Issue:19, 1997

[no title available]
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Novel pyrimidoazepine analogs as serotonin 5-HT(2A) and 5-HT(2C) receptor ligands for the treatment of obesity.
European journal of medicinal chemistry, , Volume: 63, 2013

[no title available]
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Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties.
Journal of medicinal chemistry, , Feb-14, Volume: 56, Issue:3, 2013

Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.
Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005

Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 1.
Bioorganic & medicinal chemistry letters, , Jan-21, Volume: 12, Issue:2, 2002

New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands.
Journal of medicinal chemistry, , Mar-14, Volume: 40, Issue:6, 1997

Central serotonin receptors as targets for drug research.
Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987

[no title available]
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[no title available]
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Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.
Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005

[no title available]
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3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.
Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990

[no title available]
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Central serotonin receptors as targets for drug research.
Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987

[no title available]
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Benzazaborinines as Novel Bioisosteric Replacements of Naphthalene: Propranolol as an Example.
Journal of medicinal chemistry, , Dec-10, Volume: 58, Issue:23, 2015

[no title available]
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Improved 5-HT2 Selective Receptor Modulators for the Treatment of Psychological Disorders.
ACS medicinal chemistry letters, , Dec-09, Volume: 12, Issue:12, 2021

SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist.
Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 15, Issue:20, 2005

[no title available]
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Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.
Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008

Selective optimization of side activities: another way for drug discovery.
Journal of medicinal chemistry, , Mar-11, Volume: 47, Issue:6, 2004

Current and novel approaches to the drug treatment of schizophrenia.
Journal of medicinal chemistry, , Feb-15, Volume: 44, Issue:4, 2001

Pharmacological evaluation of a diarylmethylene-piperidine derivative: a new potent atypical antipsychotic?
Bioorganic & medicinal chemistry letters, , May-21, Volume: 11, Issue:10, 2001

[no title available]
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Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines.
Journal of medicinal chemistry, , Jun-06, Volume: 40, Issue:12, 1997

Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines.
Journal of medicinal chemistry, , May-10, Volume: 39, Issue:10, 1996

Central serotonin receptors as targets for drug research.
Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987

[no title available]
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Semisynthetic Transformations on (+)-Boldine Reveal a 5-HT
Journal of natural products, , 09-23, Volume: 85, Issue:9, 2022

Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors.
Journal of medicinal chemistry, , 08-25, Volume: 65, Issue:16, 2022

Identification of a novel DGKα inhibitor for XLP-1 therapy by virtual screening.
European journal of medicinal chemistry, , Feb-15, Volume: 164, 2019

Pharmacophore-based tailoring of biphenyl amide derivatives as selective 5-hydroxytryptamine 2B receptor antagonists.
MedChemComm, , Jun-01, Volume: 9, Issue:6, 2018

New halogenated tris-(phenylalkyl)amines as h5-HT2B receptor ligands.
Bioorganic & medicinal chemistry letters, , 07-15, Volume: 26, Issue:14, 2016

Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist.
The Journal of pharmacology and experimental therapeutics, , Volume: 317, Issue:2, 2006

Synthesis and serotonergic activity of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors.
Journal of medicinal chemistry, , May-12, Volume: 38, Issue:10, 1995

Activity of
Journal of medicinal chemistry, , 09-23, Volume: 64, Issue:18, 2021

[no title available]
European journal of medicinal chemistry, , Feb-10, Volume: 145, 2018

Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia.
Journal of medicinal chemistry, , Jun-12, Volume: 57, Issue:11, 2014

Novel and selective 5-HT2C/2B receptor antagonists as potential anxiolytic agents: synthesis, quantitative structure-activity relationships, and molecular modeling of substituted 1-(3-pyridylcarbamoyl)indolines.
Journal of medicinal chemistry, , May-07, Volume: 41, Issue:10, 1998

6-Chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]- indoline (SB-242084): the first selective and brain penetrant 5-HT2C receptor antagonist.
Journal of medicinal chemistry, , Oct-24, Volume: 40, Issue:22, 1997

5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole: a novel 5-HT2C/5-HT2B receptor antagonist with improved affinity, selectivity, and oral activity.
Journal of medicinal chemistry, , Jul-07, Volume: 38, Issue:14, 1995

Central serotonin receptors as targets for drug research.
Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987

[no title available]
,

Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents.
Journal of medicinal chemistry, , Oct-24, Volume: 40, Issue:22, 1997

Synthesis and serotonergic activity of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors.
Journal of medicinal chemistry, , May-12, Volume: 38, Issue:10, 1995

[no title available]
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Selective optimization of side activities: another way for drug discovery.
Journal of medicinal chemistry, , Mar-11, Volume: 47, Issue:6, 2004

A novel ergot alkaloid as a 5-HT(1A) inhibitor produced by Dicyma sp.
Journal of medicinal chemistry, , Nov-20, Volume: 46, Issue:24, 2003

[no title available]
,

Thieno[3,2-b]- and thieno[2,3-b]pyrrole bioisosteric analogues of the hallucinogen and serotonin agonist N,N-dimethyltryptamine.
Journal of medicinal chemistry, , Mar-25, Volume: 42, Issue:6, 1999

[no title available]
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An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging 'Novel Psychoactive Drugs'.
Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 23, Issue:11, 2013

Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands.
Journal of natural products, , Volume: 69, Issue:10, 2006

[no title available]
,

Synthesis and evaluation of nuciferine and roemerine enantiomers as 5-HT
MedChemComm, , Mar-01, Volume: 9, Issue:3, 2018

Central serotonin receptors as targets for drug research.
Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987

[no title available]
,

SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist.
Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 15, Issue:20, 2005

[no title available]
,

Novel agonists of 5HT2C receptors. Synthesis and biological evaluation of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno[1,2-b]pyrrol-1-yl)-1-methylethylamines. Improved therapeutics for obsessive compulsive disorder.
Journal of medicinal chemistry, , Aug-15, Volume: 40, Issue:17, 1997

New dual 5-HT1A and 5-HT7 receptor ligands derived from SYA16263.
European journal of medicinal chemistry, , Mar-15, Volume: 214, 2021

A study of the structure-affinity relationship in SYA16263; is a D
Bioorganic & medicinal chemistry, , 01-15, Volume: 30, 2021

Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors.
Journal of natural products, , Apr-24, Volume: 78, Issue:4, 2015

Semisynthetic Transformations on (+)-Boldine Reveal a 5-HT
Journal of natural products, , 09-23, Volume: 85, Issue:9, 2022

[no title available]
,

Synthesis and structure-activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT2B and 5-HT7 receptor antagonists.
Bioorganic & medicinal chemistry, , Dec-15, Volume: 21, Issue:24, 2013

Central serotonin receptors as targets for drug research.
Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987

[no title available]
,

[no title available]
,

Analogs of penfluridol as chemotherapeutic agents with reduced central nervous system activity.
Bioorganic & medicinal chemistry letters, , 12-15, Volume: 28, Issue:23-24, 2018

1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.
Journal of medicinal chemistry, , Jan-12, Volume: 49, Issue:1, 2006

A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole.
Journal of medicinal chemistry, , Sep-11, Volume: 46, Issue:19, 2003

[no title available]
,

Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands.
Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 20, Issue:18, 2010

Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity for α(1)-adrenoceptors.
Journal of medicinal chemistry, , Oct-14, Volume: 53, Issue:19, 2010

Selective optimization of side activities: another way for drug discovery.
Journal of medicinal chemistry, , Mar-11, Volume: 47, Issue:6, 2004

4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists.
Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002

Polypharmacology - foe or friend?
Journal of medicinal chemistry, , Nov-27, Volume: 56, Issue:22, 2013

Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands.
Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 20, Issue:18, 2010

Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.
Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008

Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs.
Journal of medicinal chemistry, , Oct-18, Volume: 50, Issue:21, 2007

Selective optimization of side activities: another way for drug discovery.
Journal of medicinal chemistry, , Mar-11, Volume: 47, Issue:6, 2004

Current and novel approaches to the drug treatment of schizophrenia.
Journal of medicinal chemistry, , Feb-15, Volume: 44, Issue:4, 2001

Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants.
European journal of medicinal chemistry, , Volume: 53, 2012

[no title available]
,

Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT₆ and dopamine D₂ receptor ligands.
Journal of medicinal chemistry, , Jul-10, Volume: 57, Issue:13, 2014

2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
Journal of medicinal chemistry, , Nov-03, Volume: 48, Issue:22, 2005

Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists.
Journal of medicinal chemistry, , Jan-16, Volume: 46, Issue:2, 2003

Central serotonin receptors as targets for drug research.
Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987

[no title available]
,

[no title available]
European journal of medicinal chemistry, , Dec-01, Volume: 141, 2017

Melatonergic ligands: Design, synthesis and pharmacological evaluation of novel series of naphthofuranic derivatives.
European journal of medicinal chemistry, , Feb-15, Volume: 109, 2016

Design, synthesis and pharmacological evaluation of new series of naphthalenic analogues as melatoninergic (MT1/MT2) and serotoninergic 5-HT2C dual ligands (I).
European journal of medicinal chemistry, , Volume: 49, 2012

[no title available]
,

Synthesis of potent and selective serotonin 5-HT1B receptor ligands.
Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005

Structure-activity relationship of 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole analogues as 5-HT(6) receptor agonists.
European journal of medicinal chemistry, , Volume: 63, 2013

3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.
Journal of medicinal chemistry, , Volume: 33, Issue:8, 1990

Central serotonin receptors as targets for drug research.
Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987

Synthesis and evaluation of nuciferine and roemerine enantiomers as 5-HT
MedChemComm, , Mar-01, Volume: 9, Issue:3, 2018

[no title available]
,

(1-Butyl-4-piperidinyl)methyl 8-amino-7-chloro-1,4-benzodioxane-5-carboxylate hydrochloride: a highly potent and selective 5-HT4 receptor antagonist derived from metoclopramide.
Journal of medicinal chemistry, , Dec-10, Volume: 36, Issue:25, 1993

[no title available]
Journal of medicinal chemistry, , 12-22, Volume: 59, Issue:24, 2016

In vivo phenotypic screening for treating chronic neuropathic pain: modification of C2-arylethynyl group of conformationally constrained A3 adenosine receptor agonists.
Journal of medicinal chemistry, , Dec-11, Volume: 57, Issue:23, 2014

[no title available]
,

Synthesis and serotonergic activity of 5-(oxadiazolyl)tryptamines: potent agonists for 5-HT1D receptors.
Journal of medicinal chemistry, , May-28, Volume: 36, Issue:11, 1993

Pyrrolizidine esters and amides as 5-HT4 receptor agonists and antagonists.
Journal of medicinal chemistry, , Feb-09, Volume: 49, Issue:3, 2006

Bridgehead-methyl analog of SC-53116 as a 5-HT4 agonist.
Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 14, Issue:12, 2004

Structure-activity relationships for a novel series of dopamine D2-like receptor ligands based on N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ol.
Journal of medicinal chemistry, , Oct-09, Volume: 51, Issue:19, 2008

[no title available]
,

Central serotonin receptors as targets for drug research.
Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987

Discovery of Highly Potent Serotonin 5-HT
ACS medicinal chemistry letters, , Apr-14, Volume: 13, Issue:4, 2022

Central serotonin receptors as targets for drug research.
Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987

Binding of beta-carbolines at 5-HT(2) serotonin receptors.
Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 13, Issue:24, 2003

Special ergolines are highly selective, potent antagonists of the chemokine receptor CXCR3: discovery, characterization and preliminary SAR of a promising lead.
Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 19, Issue:21, 2009

[no title available]
,

Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine.
Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 20, Issue:2, 2010

[no title available]
,

8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 receptor antagonists.
European journal of medicinal chemistry, , Volume: 45, Issue:2, 2010

Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles.
Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 20, Issue:1, 2010

Life beyond kinases: structure-based discovery of sorafenib as nanomolar antagonist of 5-HT receptors.
Journal of medicinal chemistry, , Jun-28, Volume: 55, Issue:12, 2012

Binding of beta-carbolines at 5-HT(2) serotonin receptors.
Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 13, Issue:24, 2003

Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models.
Journal of medicinal chemistry, , Jan-28, Volume: 59, Issue:2, 2016

[no title available]
,

Novel and selective 5-HT2C/2B receptor antagonists as potential anxiolytic agents: synthesis, quantitative structure-activity relationships, and molecular modeling of substituted 1-(3-pyridylcarbamoyl)indolines.
Journal of medicinal chemistry, , May-07, Volume: 41, Issue:10, 1998

6-Chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]- indoline (SB-242084): the first selective and brain penetrant 5-HT2C receptor antagonist.
Journal of medicinal chemistry, , Oct-24, Volume: 40, Issue:22, 1997

A Divergent SAR Study Allows Optimization of a Potent 5-HT2c Inhibitor to a Promising Antimalarial Scaffold.
ACS medicinal chemistry letters, , May-10, Volume: 3, Issue:5, 2012

Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent.
Journal of medicinal chemistry, , Mar-23, Volume: 43, Issue:6, 2000

Synthesis and structure-activity relationship of 1H-indole-3-carboxylic acid pyridine-3-ylamides: a novel series of 5-HT2C receptor antagonists.
Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 18, Issue:14, 2008

A series of bisaryl imidazolidin-2-ones has shown to be selective and orally active 5-HT2C receptor antagonists.
Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 15, Issue:22, 2005

1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines: novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolytic agents.
Bioorganic & medicinal chemistry letters, , Aug-21, Volume: 10, Issue:16, 2000

Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent.
Journal of medicinal chemistry, , Mar-23, Volume: 43, Issue:6, 2000

[no title available]
,

The Essential Medicinal Chemistry of Cannabidiol (CBD).
Journal of medicinal chemistry, , 11-12, Volume: 63, Issue:21, 2020

Research progress in the biological activities of 3,4,5-trimethoxycinnamic acid (TMCA) derivatives.
European journal of medicinal chemistry, , Jul-01, Volume: 173, 2019

Design, synthesis, and biological evaluation of 3,4,5-trimethoxyphenyl acrylamides as antinarcotic agents.
Journal of enzyme inhibition and medicinal chemistry, , Volume: 25, Issue:1, 2010

[no title available]
,

Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6-tetrahydropyridines as 5-HT₂C agonists.
Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 22, Issue:7, 2012

[no title available]
,

Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET.
Bioorganic & medicinal chemistry, , Apr-15, Volume: 17, Issue:8, 2009

Activity of
Journal of medicinal chemistry, , 09-23, Volume: 64, Issue:18, 2021

[no title available]
Journal of medicinal chemistry, , 12-22, Volume: 59, Issue:24, 2016

Activity of
Journal of medicinal chemistry, , 09-23, Volume: 64, Issue:18, 2021

Fancy bioisosteres: novel paracyclophane derivatives as super-affinity dopamine D3 receptor antagonists.
Journal of medicinal chemistry, , Jun-15, Volume: 49, Issue:12, 2006

Interactive SAR studies: rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists.
Journal of medicinal chemistry, , Oct-10, Volume: 45, Issue:21, 2002

Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists.
Bioorganic & medicinal chemistry, , Feb-15, Volume: 16, Issue:4, 2008

Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.
Journal of medicinal chemistry, , Jan-24, Volume: 51, Issue:2, 2008

Pyrrolo(iso)quinoline derivatives as 5-HT(2C) receptor agonists.
Bioorganic & medicinal chemistry letters, , Volume: 16, Issue:3, 2006

Indoline derivatives as 5-HT(2C) receptor agonists.
Bioorganic & medicinal chemistry letters, , May-03, Volume: 14, Issue:9, 2004

Novel agonists of 5HT2C receptors. Synthesis and biological evaluation of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno[1,2-b]pyrrol-1-yl)-1-methylethylamines. Improved therapeutics for obsessive compulsive disorder.
Journal of medicinal chemistry, , Aug-15, Volume: 40, Issue:17, 1997

The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function b
Journal of medicinal chemistry, , Apr-09, Volume: 41, Issue:8, 1998

Synthesis and biological evaluation of thioadatanserin and its dialkylated products as partial 5-HTR
Bioorganic & medicinal chemistry letters, , 08-15, Volume: 30, Issue:16, 2020

A series of bisaryl imidazolidin-2-ones has shown to be selective and orally active 5-HT2C receptor antagonists.
Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 15, Issue:22, 2005

1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines: novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolytic agents.
Bioorganic & medicinal chemistry letters, , Aug-21, Volume: 10, Issue:16, 2000

Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent.
Journal of medicinal chemistry, , Mar-23, Volume: 43, Issue:6, 2000

6-Chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]- indoline (SB-242084): the first selective and brain penetrant 5-HT2C receptor antagonist.
Journal of medicinal chemistry, , Oct-24, Volume: 40, Issue:22, 1997

Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Bioorganic & medicinal chemistry, , 01-15, Volume: 25, Issue:2, 2017

Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Bioorganic & medicinal chemistry, , Apr-15, Volume: 24, Issue:8, 2016

Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.
European journal of medicinal chemistry, , Mar-06, Volume: 92, 2015

Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia.
Journal of medicinal chemistry, , Jun-12, Volume: 57, Issue:11, 2014

Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.
Bioorganic & medicinal chemistry, , May-15, Volume: 21, Issue:10, 2013

Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.
European journal of medicinal chemistry, , Volume: 63, 2013

cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Journal of medicinal chemistry, , Nov-27, Volume: 51, Issue:22, 2008

[no title available]
,

Binding of beta-carbolines at 5-HT(2) serotonin receptors.
Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 13, Issue:24, 2003

[no title available]
,

[no title available]
European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019

Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors.
Bioorganic & medicinal chemistry letters, , Jul-21, Volume: 13, Issue:14, 2003

Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors.
Journal of medicinal chemistry, , 08-25, Volume: 65, Issue:16, 2022

Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands.
Bioorganic & medicinal chemistry letters, , Jun-04, Volume: 11, Issue:11, 2001

Current and novel approaches to the drug treatment of schizophrenia.
Journal of medicinal chemistry, , Feb-15, Volume: 44, Issue:4, 2001

3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.
Journal of medicinal chemistry, , May-10, Volume: 39, Issue:10, 1996

Novel spirotetracyclic zwitterionic dual H(1)/5-HT(2A) receptor antagonists for the treatment of sleep disorders.
Journal of medicinal chemistry, , Nov-11, Volume: 53, Issue:21, 2010

Non-basic ligands for aminergic GPCRs: the discovery and development diaryl sulfones as selective, orally bioavailable 5-HT2A receptor antagonists for the treatment of sleep disorders.
Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010

Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET.
Bioorganic & medicinal chemistry, , Apr-15, Volume: 17, Issue:8, 2009

4-Fluorosulfonylpiperidines: selective 5-HT2A ligands for the treatment of insomnia.
Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 15, Issue:16, 2005

4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists.
Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002

5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole: a novel 5-HT2C/5-HT2B receptor antagonist with improved affinity, selectivity, and oral activity.
Journal of medicinal chemistry, , Jul-07, Volume: 38, Issue:14, 1995

N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea: a novel, high-affinity 5-HT2B receptor antagonist.
Journal of medicinal chemistry, , Mar-17, Volume: 38, Issue:6, 1995

(R)-3,N-dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl) propyl]benzenesulfonamide: the first selective 5-HT7 receptor antagonist.
Journal of medicinal chemistry, , Feb-26, Volume: 41, Issue:5, 1998

Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT₆ and dopamine D₂ receptor ligands.
Journal of medicinal chemistry, , Jul-10, Volume: 57, Issue:13, 2014

Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists.
Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 18, Issue:2, 2008

Bicyclic piperazinylbenzenesulphonamides are potent and selective 5-HT6 receptor antagonists.
Bioorganic & medicinal chemistry letters, , May-20, Volume: 12, Issue:10, 2002

Central serotonin receptors as targets for drug research.
Journal of medicinal chemistry, , Volume: 30, Issue:1, 1987

[no title available]
,

Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents.
Journal of medicinal chemistry, , Oct-24, Volume: 40, Issue:22, 1997

Discovery of G Protein-Biased Antagonists against 5-HT
Journal of medicinal chemistry, , 09-23, Volume: 64, Issue:18, 2021

Synthesis and evaluation of the structural elements in alkylated tetrahydroisoquinolines for binding to CNS receptors.
Bioorganic & medicinal chemistry, , 11-15, Volume: 24, Issue:22, 2016

A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970).
Journal of medicinal chemistry, , Feb-10, Volume: 43, Issue:3, 2000

Identification of highly selective and potent orexin receptor 1 antagonists derived from a dual orexin receptor 1/2 antagonist based on the structural framework of pyrazoylethylbenzamide.
Bioorganic & medicinal chemistry, , 10-15, Volume: 25, Issue:20, 2017

1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor.
Bioorganic & medicinal chemistry letters, , Jul-23, Volume: 11, Issue:14, 2001

2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists.
Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 15, Issue:19, 2005

Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134).
Bioorganic & medicinal chemistry letters, , Jan-08, Volume: 11, Issue:1, 2001

Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist.
Journal of medicinal chemistry, , Mar-27, Volume: 46, Issue:7, 2003

Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.
Journal of medicinal chemistry, , Jan-24, Volume: 51, Issue:2, 2008

[no title available]
,

Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3 receptor ligands: potential substance abuse therapeutic agents.
Journal of medicinal chemistry, , Aug-23, Volume: 50, Issue:17, 2007

1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.
Journal of medicinal chemistry, , Jan-12, Volume: 49, Issue:1, 2006

A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole.
Journal of medicinal chemistry, , Sep-11, Volume: 46, Issue:19, 2003

A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970).
Journal of medicinal chemistry, , Feb-10, Volume: 43, Issue:3, 2000

Design and synthesis of novel RXR-selective modulators with improved pharmacological profile.
Bioorganic & medicinal chemistry letters, , Nov-17, Volume: 13, Issue:22, 2003

Interactive SAR studies: rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists.
Journal of medicinal chemistry, , Oct-10, Volume: 45, Issue:21, 2002

Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents.
Journal of medicinal chemistry, , Feb-26, Volume: 58, Issue:4, 2015

Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties.
Journal of medicinal chemistry, , Feb-14, Volume: 56, Issue:3, 2013

Identification of novel serotonin 2C receptor ligands by sequential virtual screening.
Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009

Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.
Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008

Evaluation of the eutomer of 4-{3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl}-1-(4-fluorophenyl)butan-1-one, {(+)-SYA 09}, a pyrrolidine analog of haloperidol.
Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 16, Issue:12, 2006

Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.
Journal of medicinal chemistry, , Sep-09, Volume: 53, Issue:17, 2010

Novel 4-substituted-N,N-dimethyltetrahydronaphthalen-2-amines: synthesis, affinity, and in silico docking studies at serotonin 5-HT2-type and histamine H1 G protein-coupled receptors.
Bioorganic & medicinal chemistry, , Apr-01, Volume: 23, Issue:7, 2015

SB-656104-A: a novel 5-HT(7) receptor antagonist with improved in vivo properties.
Bioorganic & medicinal chemistry letters, , Nov-18, Volume: 12, Issue:22, 2002

Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors.
Journal of medicinal chemistry, , 08-25, Volume: 65, Issue:16, 2022

Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist.
The Journal of pharmacology and experimental therapeutics, , Volume: 317, Issue:2, 2006

Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors.
Journal of medicinal chemistry, , 08-25, Volume: 65, Issue:16, 2022

Discovery of a lead series of potent benzodiazepine 5-HT
Bioorganic & medicinal chemistry letters, , 03-01, Volume: 30, Issue:5, 2020

Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents.
Journal of medicinal chemistry, , Feb-26, Volume: 58, Issue:4, 2015

Imaging evaluation of 5HT2C agonists, [(11)C]WAY-163909 and [(11)C]vabicaserin, formed by Pictet-Spengler cyclization.
Journal of medicinal chemistry, , Feb-27, Volume: 57, Issue:4, 2014

2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists.
Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 15, Issue:19, 2005

Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist.
Journal of medicinal chemistry, , Nov-15, Volume: 50, Issue:23, 2007

Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors.
Journal of medicinal chemistry, , 08-25, Volume: 65, Issue:16, 2022

3,4-Dihydro-2H-benzoxazinones as dual-acting 5-HT1A receptor antagonists and serotonin reuptake inhibitors.
Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 17, Issue:4, 2007

Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists.
Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009

Potential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation.
Journal of medicinal chemistry, , Nov-13, Volume: 51, Issue:21, 2008

CNS and antimalarial activity of synthetic meridianin and psammopemmin analogs.
Bioorganic & medicinal chemistry, , Oct-01, Volume: 19, Issue:19, 2011

Non-basic ligands for aminergic GPCRs: the discovery and development diaryl sulfones as selective, orally bioavailable 5-HT2A receptor antagonists for the treatment of sleep disorders.
Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010

A new class of selective, non-basic 5-HT2A receptor antagonists.
Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 16, Issue:12, 2006

4-Fluorosulfonylpiperidines: selective 5-HT2A ligands for the treatment of insomnia.
Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 15, Issue:16, 2005

4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists.
Journal of medicinal chemistry, , Jan-17, Volume: 45, Issue:2, 2002

2-Phenylcyclopropylmethylamine Derivatives as Dopamine D
Journal of medicinal chemistry, , 12-09, Volume: 64, Issue:23, 2021

Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands.
Journal of natural products, , Volume: 69, Issue:10, 2006

1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors.
Journal of medicinal chemistry, , Feb-23, Volume: 49, Issue:4, 2006

An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
Journal of medicinal chemistry, , Jun-01, Volume: 49, Issue:11, 2006

Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors.
Journal of medicinal chemistry, , 08-25, Volume: 65, Issue:16, 2022

Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents.
Journal of medicinal chemistry, , Feb-26, Volume: 58, Issue:4, 2015

Imaging evaluation of 5HT2C agonists, [(11)C]WAY-163909 and [(11)C]vabicaserin, formed by Pictet-Spengler cyclization.
Journal of medicinal chemistry, , Feb-27, Volume: 57, Issue:4, 2014

Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors.
Journal of medicinal chemistry, , 08-25, Volume: 65, Issue:16, 2022

Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579.
European journal of medicinal chemistry, , Volume: 66, 2013

Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound.
European journal of medicinal chemistry, , Volume: 62, 2013

Discovery, oral pharmacokinetics and in vivo efficacy of velusetrag, a highly selective 5-HT(4) receptor agonist that has achieved proof-of-concept in patients with chronic idiopathic constipation.
Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 22, Issue:19, 2012

Activity of
Journal of medicinal chemistry, , 09-23, Volume: 64, Issue:18, 2021

A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.
Proceedings of the National Academy of Sciences of the United States of America, , May-15, Volume: 104, Issue:20, 2007

Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography.
Journal of medicinal chemistry, , Jul-12, Volume: 50, Issue:14, 2007

Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT₆ and dopamine D₂ receptor ligands.
Journal of medicinal chemistry, , Jul-10, Volume: 57, Issue:13, 2014

Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity.
Journal of medicinal chemistry, , Oct-18, Volume: 50, Issue:21, 2007

[no title available]
,

Selective 5-HT2C receptor agonists: Design and synthesis of pyridazine-fused azepines.
Bioorganic & medicinal chemistry letters, , 08-15, Volume: 26, Issue:16, 2016

Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors.
Journal of medicinal chemistry, , Jun-26, Volume: 57, Issue:12, 2014

Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence.
Bioorganic & medicinal chemistry letters, , May-01, Volume: 21, Issue:9, 2011

Spiroindolones, a potent compound class for the treatment of malaria.
Science (New York, N.Y.), , Sep-03, Volume: 329, Issue:5996, 2010

Receptor binding profiles and quantitative structure-affinity relationships of some 5-substituted-N,N-diallyltryptamines.
Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 26, Issue:3, 2016

An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging 'Novel Psychoactive Drugs'.
Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 23, Issue:11, 2013

Target	Category	Definition
Gq/11-coupled serotonin receptor activity	molecular function	Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels. [GOC:bf, GOC:mah, PMID:18571247, PMID:18703043]
G protein-coupled serotonin receptor activity	molecular function	Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. [GOC:ai]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
serotonin binding	molecular function	Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. [GOC:ai]
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	molecular function	Binding to the amine 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine, a serotonin receptor agonist that can act as a psychedelic drug. [GOC:yaf, PMID:19057895]
neurotransmitter receptor activity	molecular function	Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. [GOC:jl, GOC:signaling]

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
synapse	cellular component	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
dendrite	cellular component	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]

Target	Category	Definition
behavioral fear response	biological process	An acute behavioral change resulting from a perceived external threat. [GOC:dph, PMID:9920659]
intracellular calcium ion homeostasis	biological process	A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell. [GOC:ceb, GOC:mah]
phospholipase C-activating G protein-coupled receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
phospholipase C-activating serotonin receptor signaling pathway	biological process	A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]
locomotory behavior	biological process	The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. [GOC:dph]
feeding behavior	biological process	Behavior associated with the intake of food. [GOC:mah]
positive regulation of phosphatidylinositol biosynthetic process	biological process	Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol. [GOC:dph, GOC:tb, GOC:vw]
cGMP-mediated signaling	biological process	An intracellular signaling cassette that starts with production of cyclic GMP (cGMP), and ends with activation of downstream effectors that further transmit the signal within the cell. [GOC:signaling]
regulation of nervous system process	biological process	Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system. [GOC:dph, GOC:mah, GOC:tb]
regulation of appetite	biological process	Any process which modulates appetite, the desire or physical craving for food. [GOC:add]
regulation of corticotropin-releasing hormone secretion	biological process	Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone secretion. [GOC:go_curators, PMID:11027914]
positive regulation of fat cell differentiation	biological process	Any process that activates or increases the frequency, rate or extent of adipocyte differentiation. [GOC:go_curators]
positive regulation of calcium-mediated signaling	biological process	Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling. [GOC:ai]
release of sequestered calcium ion into cytosol	biological process	The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment. [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]
positive regulation of ERK1 and ERK2 cascade	biological process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah]
G protein-coupled serotonin receptor signaling pathway	biological process	The series of molecular signals generated as a consequence of a G protein-coupled serotonin receptor binding to one of its physiological ligands. [GOC:mah]
serotonin receptor signaling pathway	biological process	The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands. [GOC:mah]
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. [GOC:mah, GOC:signaling, ISBN:0815316194]
chemical synaptic transmission	biological process	The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435]

5-hydroxytryptamine receptor 2C

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Research

Bioassay Publications (192)

Compounds (251)

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