Page last updated: 2024-10-20

uric acid and Necrosis

uric acid has been researched along with Necrosis in 47 studies

Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
" Acetaminophen is a commonly used analgesic and antipyretic agent which, at high doses, causes liver and kidney necrosis in man and animals."3.77Evaluation of phytoconstituents and anti-nephrotoxic and antioxidant activities of Monochoria vaginalis. ( Kumar, BS; Kumar, RP; Palani, S; Raja, S; Selvaraj, R, 2011)
" Because the renal biopsy revealed acute tubular necrosis without uric acid crystals, the ARF of this patient might be due to oxygen free radicals resulting from exercise stress and hypouricemia."3.70Exercise-induced acute renal failure in a patient with renal hypouricemia. ( Abe, T; Oda, Y; Watanabe, T, 2000)
" Furthermore, 5 days of allopurinol treatment (25 mg/kg iv twice daily) starting 2 days before ischemia or 3 days of oxypurinol treatment (25 mg/kg iv twice daily) starting 15 min before reperfusion did not attenuate the extent of skeletal muscle necrosis in pig LD muscles subjected to 5 h of ischemia and 48 h of reperfusion."3.68Role of xanthine oxidase in reperfusion injury of ischemic skeletal muscles in the pig and human. ( Boyd, B; Chiu, C; Dorion, D; Forrest, CR; Pang, CY; Zhong, A, 1993)
"Gout is a metabolic disorder that results in hyperuricemia and the deposition of positively birefringent monosodium urate crystals in various parts of the body."1.42Clinicopathologic characterization of visceral gout of various internal organs--a study of 2 cases from a venom and toxin research center. ( Fayyaz, AF; Kamyabi-Moghaddam, Z; Mokarizadeh, A; Nasoori, A; Pedram, B; Pirasteh, H; Shooshtari, MB, 2015)
"Necrosis was assessed by acridine orange and ethidium bromide."1.37Pro-inflammatory and oxidative effects of noncrystalline uric acid in human mesangial cells: contribution to hyperuricemic glomerular damage. ( Borges, FT; Convento, MS; Dalboni, MA; Pessoa, E; Schor, N, 2011)
"Methyl parathion (MP) is a pesticide widely used to protect crops but also illegally used in many countries for spraying homes and businesses to contain insects."1.33The reproductive toxicity of the organophosphate pesticide 0, 0-dimethyl 0-4-nitrophenyl phosphorothioate (methyl parathion) in the male rat. ( Bairy, KL; Chandra Kumar, HH; D'Souza, UJ; Narayana, K; Nayanatara, A; Prashanthi, N, 2006)
"Gentamicin treated rats exhibited a 63% increase in blood urea nitrogen (BUN), a 124% increase in uric acid, and a 63% decrease in serum potassium levels on day 15."1.29Nephrotoxicity of gentamicin and co-trimoxazole combination in rats. ( Ayça, B; Cevikbaş, U; Izzettin, FV; Stohs, SJ; Uras, F; Uysal, V; Yardimci, T, 1994)
"Treatment with uric acid, at doses of 50, 100 or 300 mg/kg body weight, by gavage, provided some measure of protection against all of these effects, and the protection was generally dose dependent."1.28A study of uric acid pretreatment for the protection of rat gastric mucosa against toxic damage. ( Afal, M; Ahmed, MM; al-Bekairi, AM; Qureshi, S; Shah, AH, 1992)
"Generalized osteoarthrosis was found to be significantly more common in older males with high than with low diastolic blood pressure."1.25Hypertension in relation to musculoskeletal disorders. ( Lawrence, JS, 1975)

Research

Studies (47)

TimeframeStudies, this research(%)All Research%
pre-199020 (42.55)18.7374
1990's6 (12.77)18.2507
2000's7 (14.89)29.6817
2010's11 (23.40)24.3611
2020's3 (6.38)2.80

Authors

AuthorsStudies
Farooq, M1
Khan, AA1
Fautrel, B1
Belhassen, M1
Hudry, C1
Woronoff-Lemsi, MC1
Levy-Bachelot, L1
Van Ganse, E1
Tubach, F1
Zhong, CS1
Zeng, B1
Qiu, JH1
Xu, LH1
Zhong, MY1
Huang, YT1
Xu, R1
Liu, SY1
Zha, QB1
Hu, B1
Ou-Yang, DY1
He, XH1
Desai, J3
Foresto-Neto, O2
Honarpisheh, M2
Steiger, S2
Nakazawa, D1
Popper, B3
Buhl, EM1
Boor, P2
Mulay, SR3
Anders, HJ3
Gómez, LA1
Poornima, K1
Chella Perumal, P1
Gopalakrishnan, VK1
Kataoka, H1
Yang, K1
Rock, KL2
Nasoori, A1
Pedram, B1
Kamyabi-Moghaddam, Z1
Mokarizadeh, A1
Pirasteh, H1
Fayyaz, AF1
Shooshtari, MB1
Kumar, SV1
Eberhard, JN1
Thomasova, D1
Romoli, S1
Grigorescu, M1
Kulkarni, OP1
Vielhauer, V1
Zuchtriegel, G1
Reichel, C1
Bräsen, JH1
Romagnani, P1
Bilyy, R1
Munoz, LE1
Herrmann, M1
Liapis, H1
Krautwald, S1
Linkermann, A1
Sloane, JA1
Blitz, D1
Margolin, Z1
Vartanian, T1
Kono, H1
Chen, CJ1
Ontiveros, F1
Convento, MS1
Pessoa, E1
Dalboni, MA2
Borges, FT2
Schor, N2
Michelacci, YM1
Palani, S1
Raja, S1
Kumar, RP1
Selvaraj, R1
Kumar, BS1
FREUDWEILER, M1
Skoberne, M1
Beignon, AS1
Bhardwaj, N1
Saxena, R1
Loghmanee, F1
Duarte, AI1
Santos, MS1
Oliveira, CR1
Rego, AC1
Prashanthi, N1
Narayana, K1
Nayanatara, A1
Chandra Kumar, HH1
Bairy, KL1
D'Souza, UJ1
Róka, A1
Vásárhelyi, B1
Bodrogi, E1
Machay, T1
Szabó, M1
Jeremy, R1
Orvoine, RH1
Letellier, G1
Lapointe, Y1
Landolt, H1
Langemann, H1
Probst, A1
Gratzl, O1
Izzettin, FV1
Ayça, B1
Uras, F1
Uysal, V1
Cevikbaş, U1
Yardimci, T1
Stohs, SJ1
Dorion, D1
Zhong, A1
Chiu, C1
Forrest, CR1
Boyd, B1
Pang, CY1
Iwata, J1
Watanabe, T1
Abe, T1
Oda, Y1
Kossard, S1
Scurry, J1
Killingsworth, M1
Butler, RC1
Shah, SM1
Grunow, WA1
Texter, C1
Knochel, JP1
Lawrence, JS1
al-Bekairi, AM1
Qureshi, S1
Ahmed, MM1
Afal, M1
Shah, AH1
Numabe, A1
Tsukada, H1
Sugimoto, T1
Ono, H1
Hirao, S1
Abe, M1
Yagi, S1
Müller-Schweinitzer, E1
Maldyk, E1
Kawenoki-Minc, E1
Polowiec, Z1
Wagner, T1
Zsernaviczky, J1
von Torklus, D2
Wilke, H2
Frahm, H2
Viala, JJ1
Marcellin, J1
Dechavanne, M1
Druget, M1
Scott, HW1
Dean, R1
Shull, HJ1
Abram, HS1
Webb, W1
Younger, RK1
Brill, AB1
Stavric, B1
Nera, EA1
Johnson, WJ1
Salem, FA1
Quigley, MM1
Espinoza, LR1
Spilberg, I1
Osterland, CK1
Zsernaviezky, J1
McCollum, DE1
Mathews, RS1
O'NEIL, MT1
Boettcher, WG1
Bonfiglio, M1
Hamilton, HH1
Sheets, RF1
Smith, K1
Frenkel, G1
Kraicer, PF1
Munsat, TL1
Klinenberg, J1
Carell, RE1
Menkes, J1
Hunder, GG1
Worthington, JW1
Bickel, WH1

Reviews

4 reviews available for uric acid and Necrosis

ArticleYear
A clear and present danger: endogenous ligands of Toll-like receptors.
    Neuromolecular medicine, 2010, Volume: 12, Issue:2

    Topics: Apoptosis; Central Nervous System; Central Nervous System Diseases; Extracellular Matrix; Heat-Shock

2010
Danger signals: a time and space continuum.
    Trends in molecular medicine, 2004, Volume: 10, Issue:6

    Topics: Animals; Apoptosis; Cell Differentiation; Dendritic Cells; Humans; Immune Tolerance; Immunity, Innat

2004
[Hyperuricemia in hematological disorders].
    Nihon rinsho. Japanese journal of clinical medicine, 1996, Volume: 54, Issue:12

    Topics: Bone Marrow; Bone Marrow Diseases; Hematologic Diseases; Humans; Kidney Diseases; Necrosis; Tumor Ly

1996
Renal injury in mu.
    Perspectives in nephrology and hypertension, 1976, Volume: 3

    Topics: Acute Kidney Injury; Adult; Animals; Glomerular Filtration Rate; Hemodynamics; Humans; Hypokalemia;

1976

Trials

2 trials available for uric acid and Necrosis

ArticleYear
Changes in laboratory parameters indicating cell necrosis and organ dysfunction in asphyxiated neonates on moderate systemic hypothermia.
    Acta paediatrica (Oslo, Norway : 1992), 2007, Volume: 96, Issue:8

    Topics: Alanine Transaminase; Area Under Curve; Aspartate Aminotransferases; Asphyxia Neonatorum; Biomarkers

2007
[Letter: Rise in blood levels in uric acid and of lacticodehydrogenase, cellular lysis, and aggraviation of certain hemopathies].
    La Nouvelle presse medicale, 1974, Feb-16, Volume: 3, Issue:7

    Topics: Bone Marrow Examination; Clinical Trials as Topic; Humans; L-Lactate Dehydrogenase; Leukemia, Lympho

1974

Other Studies

41 other studies available for uric acid and Necrosis

ArticleYear
Evaluation of histo-toxicity of nimesulide in Black Kites (Milvus migrans): a pharmacodynamic study.
    Brazilian journal of biology = Revista brasleira de biologia, 2023, Volume: 83

    Topics: Adult; Animals; Birds; Body Weight; Humans; Male; Necrosis; Raptors; Uric Acid

2023
Predictive factors of tumour necrosis inhibitor treatment persistence for rheumatoid arthritis: An observational study in 8052 patients.
    Joint bone spine, 2020, Volume: 87, Issue:2

    Topics: Aged; Arthritis, Rheumatoid; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Necrosis; N

2020
Gout-associated monosodium urate crystal-induced necrosis is independent of NLRP3 activity but can be suppressed by combined inhibitors for multiple signaling pathways.
    Acta pharmacologica Sinica, 2022, Volume: 43, Issue:5

    Topics: Animals; Arthritis, Gouty; Gout; Inflammasomes; Interleukin-1beta; Mice; Necrosis; NLR Family, Pyrin

2022
Particles of different sizes and shapes induce neutrophil necroptosis followed by the release of neutrophil extracellular trap-like chromatin.
    Scientific reports, 2017, 11-03, Volume: 7, Issue:1

    Topics: Animals; Calcium Oxalate; Calcium Phosphates; Cell Death; Cholesterol; Chromatin; Extracellular Trap

2017
Phagocytosis of environmental or metabolic crystalline particles induces cytotoxicity by triggering necroptosis across a broad range of particle size and shape.
    Scientific reports, 2017, Nov-14, Volume: 7, Issue:1

    Topics: Animals; Apoptosis; Calcium Oxalate; Calcium Phosphates; Cell Line; Cholesterol; Crystallization; Cy

2017
Protective effect of ethanolic extract of Tabernaemontana divaricata (L.) R. Br. against DEN and Fe NTA induced liver necrosis in Wistar Albino rats.
    BioMed research international, 2014, Volume: 2014

    Topics: Alkylating Agents; Animals; Antimetabolites; Antioxidants; Bilirubin; Biomarkers; Carcinogens; Chemi

2014
The xanthine oxidase inhibitor Febuxostat reduces tissue uric acid content and inhibits injury-induced inflammation in the liver and lung.
    European journal of pharmacology, 2015, Jan-05, Volume: 746

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Death; Chemical and Drug Induced Liver Injury

2015
Clinicopathologic characterization of visceral gout of various internal organs--a study of 2 cases from a venom and toxin research center.
    Diagnostic pathology, 2015, Apr-09, Volume: 10

    Topics: Animals; Animals, Laboratory; Autopsy; Biopsy; Cause of Death; Crystallization; Elapidae; Gout; Gran

2015
Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis.
    Nature communications, 2016, Jan-28, Volume: 7

    Topics: Animals; Apoptosis; Calcium Oxalate; Calcium Pyrophosphate; Humans; Kidney Diseases; Mice; Mice, Inb

2016
Uric acid promotes an acute inflammatory response to sterile cell death in mice.
    The Journal of clinical investigation, 2010, Volume: 120, Issue:6

    Topics: Animals; Cell Death; Cells; Immune System; Inflammation; Mice; Mice, Inbred C57BL; Mice, Inbred Stra

2010
Pro-inflammatory and oxidative effects of noncrystalline uric acid in human mesangial cells: contribution to hyperuricemic glomerular damage.
    Urological research, 2011, Volume: 39, Issue:1

    Topics: Cell Line, Transformed; Cell Survival; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Dose-Respons

2011
Noncrystalline uric acid inhibits proteoglycan and glycosaminoglycan synthesis in distal tubular epithelial cells (MDCK).
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2010, Volume: 43, Issue:10

    Topics: Animals; Apoptosis; Cell Line; Cyclooxygenase 2; Dinoprostone; Dogs; Electrophoresis, Agar Gel; Endo

2010
Evaluation of phytoconstituents and anti-nephrotoxic and antioxidant activities of Monochoria vaginalis.
    Pakistan journal of pharmaceutical sciences, 2011, Volume: 24, Issue:3

    Topics: Acetaminophen; Animals; Antioxidants; Creatine; Disease Models, Animal; Ethanol; Kidney Diseases; Ma

2011
EXPERIMENTAL INVESTIGATIONS INTO THE ORIGIN OF GOUTY TOPHI.
    Arthritis and rheumatism, 1965, Volume: 8

    Topics: Animals; Gout; History; Humans; Inflammation; Necrosis; Pathology; Poultry; Rabbits; Research; Uric

1965
Fatal drug reaction due to allopurinol therapy in a 72-year-old man.
    Archives of pathology & laboratory medicine, 2005, Volume: 129, Issue:8

    Topics: Aged; Allopurinol; Epidermis; Fatal Outcome; Gout Suppressants; Humans; Kidney Failure, Chronic; Mal

2005
Insulin neuroprotection against oxidative stress in cortical neurons--involvement of uric acid and glutathione antioxidant defenses.
    Free radical biology & medicine, 2005, Oct-01, Volume: 39, Issue:7

    Topics: Aldehydes; Animals; Apoptosis; Ascorbic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Femal

2005
The reproductive toxicity of the organophosphate pesticide 0, 0-dimethyl 0-4-nitrophenyl phosphorothioate (methyl parathion) in the male rat.
    Folia morphologica, 2006, Volume: 65, Issue:4

    Topics: Acid Phosphatase; Animals; Cholesterol; Dose-Response Relationship, Drug; Epididymis; Insecticides;

2006
Non-traumatic aseptic necrosis of the femoral head.
    The Medical journal of Australia, 1967, Feb-18, Volume: 1, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Alcoholism; Fats; Female; Femoral Fractures; Femur Head; Gout; Hip D

1967
Systemic tolerance of osmotically induced oncolysis in rats.
    Journal of the National Cancer Institute, 1983, Volume: 70, Issue:5

    Topics: Animals; Aspartate Aminotransferases; Body Weight; Diuresis; Drinking; Eating; Female; Fructose; Glu

1983
Levels of water-soluble antioxidants in astrocytoma and in adjacent tumor-free tissue.
    Journal of neuro-oncology, 1994, Volume: 21, Issue:2

    Topics: Adult; Aged; Antioxidants; Artifacts; Ascorbic Acid; Astrocytoma; Biopsy; Brain Chemistry; Brain Ede

1994
Nephrotoxicity of gentamicin and co-trimoxazole combination in rats.
    General pharmacology, 1994, Volume: 25, Issue:6

    Topics: Animals; Blood Urea Nitrogen; Drug Therapy, Combination; Gentamicins; Kidney; Necrosis; Potassium; R

1994
Role of xanthine oxidase in reperfusion injury of ischemic skeletal muscles in the pig and human.
    Journal of applied physiology (Bethesda, Md. : 1985), 1993, Volume: 75, Issue:1

    Topics: Adult; Allopurinol; Animals; Blood Cell Count; Chromatography, High Pressure Liquid; Female; Humans;

1993
Exercise-induced acute renal failure in a patient with renal hypouricemia.
    Pediatric nephrology (Berlin, Germany), 2000, Volume: 14, Issue:8-9

    Topics: Acute Kidney Injury; Child; Creatinine; Exercise; Follow-Up Studies; Humans; Kidney; Kidney Tubules;

2000
Necrotizing infundibular crystalline folliculitis.
    The British journal of dermatology, 2001, Volume: 145, Issue:1

    Topics: Adult; Crystallization; Facial Dermatoses; Female; Folliculitis; Humans; Necrosis; Uric Acid

2001
Massive hepatic necrosis in a patient receiving allopurinol.
    JAMA, 1977, Jan-31, Volume: 237, Issue:5

    Topics: Allopurinol; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Humans; Middle A

1977
Hypertension in relation to musculoskeletal disorders.
    Annals of the rheumatic diseases, 1975, Volume: 34, Issue:5

    Topics: Blood Pressure; Cholesterol; Female; Humans; Hypertension; Intervertebral Disc; Knee Joint; Male; Ne

1975
A study of uric acid pretreatment for the protection of rat gastric mucosa against toxic damage.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1992, Volume: 30, Issue:6

    Topics: Animals; DNA; Dose-Response Relationship, Drug; Ethanol; Gastric Mucosa; Male; Mucus; Necrosis; Prot

1992
[A case of acute renal failure in a patient with idiopathic hypouricemia].
    Nihon Jinzo Gakkai shi, 1992, Volume: 34, Issue:7

    Topics: Acute Kidney Injury; Adolescent; Humans; Kidney Tubules; Male; Necrosis; Uric Acid

1992
[Diagnosis and etiology of aseptic femoral head necrosis in adults].
    Zeitschrift fur Orthopadie und ihre Grenzgebiete, 1970, Volume: 108, Issue:2

    Topics: Adult; Age Factors; Alcoholism; Arthritis; Bone Diseases; Cortisone; Female; Femur Head; Follow-Up S

1970
Microscopic appearance and histogenesis of gouty tophus.
    Polish medical journal, 1972, Volume: 11, Issue:5

    Topics: Connective Tissue; Crystallization; Ear; Extremities; Glycosaminoglycans; Gout; Humans; Necrosis; Sk

1972
[Multiple osteonecrosis with type IV hyperlipoproteinemia (author's transl)].
    Zeitschrift fur Orthopadie und ihre Grenzgebiete, 1974, Volume: 112, Issue:5

    Topics: Adult; Blood Protein Disorders; Bone Diseases; Glucose Tolerance Test; Gout; Hip Joint; Humans; Hype

1974
Considerations in use of jejunoileal bypass in patients with morbid obesity.
    Annals of surgery, 1973, Volume: 177, Issue:6

    Topics: Adolescent; Adult; Alkaline Phosphatase; Ascorbic Acid; Aspartate Aminotransferases; Bilirubin; Caro

1973
Uric acid kidney stones induced in rats by oxonic acid, a uricase inhibitor.
    Investigative urology, 1973, Volume: 11, Issue:1

    Topics: Animals; Blood Urea Nitrogen; Body Weight; Epithelial Cells; Kidney; Kidney Calculi; Kidney Cortex;

1973
Acute obstetric yellow atrophy presenting as idiopathic hyperuricemia.
    Southern medical journal, 1974, Volume: 67, Issue:2

    Topics: Acute Kidney Injury; Adult; Blood Coagulation Tests; Bronchopneumonia; Cytoplasm; Diagnosis, Differe

1974
Joint manifestations of sickle cell disease.
    Medicine, 1974, Volume: 53, Issue:4

    Topics: Adolescent; Adult; Anemia, Sickle Cell; Arthritis; Bone and Bones; Child; Child, Preschool; Erythroc

1974
[Multiple aseptic bone necrosis in hyperlipidaemia, hyperuricaemia, and latent diabetes mellitus (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1974, Jul-19, Volume: 99, Issue:29

    Topics: Adult; Allopurinol; Bone Diseases; Clofibrate; Diet Therapy; Dietary Carbohydrates; Femur Head Necro

1974
Aseptic necrosis of the femoral head: associated diseases and evaluation of treatment.
    Southern medical journal, 1970, Volume: 63, Issue:3

    Topics: Adult; Age Factors; Anemia, Sickle Cell; Bone Diseases; Female; Femoral Fractures; Femur Head; Fluor

1970
Non-traumatic necrosis of the femoral head. I. Relation of altered hemostasis to etiology.
    The Journal of bone and joint surgery. American volume, 1970, Volume: 52, Issue:2

    Topics: Alcohol Drinking; Blood Coagulation Disorders; Blood Coagulation Tests; Blood Platelet Disorders; Fe

1970
The inhibition of adrenocortical function in the lizard Agama stellio.
    General and comparative endocrinology, 1971, Volume: 17, Issue:1

    Topics: Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Glands; Animals; Blood Glucose; Depression,

1971
Defects in purine metabolism and neurologic disease.
    Bulletin of the Los Angeles neurological societies, 1968, Volume: 33, Issue:2

    Topics: Brain; Cerebellum; Child; Glucosyltransferases; Gout; Hemorrhage; Humans; Male; Necrosis; Nervous Sy

1968
Avascular necrosis of the femoral head in a patient with gout.
    JAMA, 1968, Jan-01, Volume: 203, Issue:1

    Topics: Adult; Amputation, Surgical; Bone Diseases; Femur Head; Gout; Hip Joint; Humans; Male; Necrosis; Rad

1968