uric acid has been researched along with Necrosis in 47 studies
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
uric acid : An oxopurine that is the final oxidation product of purine metabolism.
6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.
7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Acetaminophen is a commonly used analgesic and antipyretic agent which, at high doses, causes liver and kidney necrosis in man and animals." | 3.77 | Evaluation of phytoconstituents and anti-nephrotoxic and antioxidant activities of Monochoria vaginalis. ( Kumar, BS; Kumar, RP; Palani, S; Raja, S; Selvaraj, R, 2011) |
| " Because the renal biopsy revealed acute tubular necrosis without uric acid crystals, the ARF of this patient might be due to oxygen free radicals resulting from exercise stress and hypouricemia." | 3.70 | Exercise-induced acute renal failure in a patient with renal hypouricemia. ( Abe, T; Oda, Y; Watanabe, T, 2000) |
| " Furthermore, 5 days of allopurinol treatment (25 mg/kg iv twice daily) starting 2 days before ischemia or 3 days of oxypurinol treatment (25 mg/kg iv twice daily) starting 15 min before reperfusion did not attenuate the extent of skeletal muscle necrosis in pig LD muscles subjected to 5 h of ischemia and 48 h of reperfusion." | 3.68 | Role of xanthine oxidase in reperfusion injury of ischemic skeletal muscles in the pig and human. ( Boyd, B; Chiu, C; Dorion, D; Forrest, CR; Pang, CY; Zhong, A, 1993) |
| "Gout is a metabolic disorder that results in hyperuricemia and the deposition of positively birefringent monosodium urate crystals in various parts of the body." | 1.42 | Clinicopathologic characterization of visceral gout of various internal organs--a study of 2 cases from a venom and toxin research center. ( Fayyaz, AF; Kamyabi-Moghaddam, Z; Mokarizadeh, A; Nasoori, A; Pedram, B; Pirasteh, H; Shooshtari, MB, 2015) |
| "Necrosis was assessed by acridine orange and ethidium bromide." | 1.37 | Pro-inflammatory and oxidative effects of noncrystalline uric acid in human mesangial cells: contribution to hyperuricemic glomerular damage. ( Borges, FT; Convento, MS; Dalboni, MA; Pessoa, E; Schor, N, 2011) |
| "Methyl parathion (MP) is a pesticide widely used to protect crops but also illegally used in many countries for spraying homes and businesses to contain insects." | 1.33 | The reproductive toxicity of the organophosphate pesticide 0, 0-dimethyl 0-4-nitrophenyl phosphorothioate (methyl parathion) in the male rat. ( Bairy, KL; Chandra Kumar, HH; D'Souza, UJ; Narayana, K; Nayanatara, A; Prashanthi, N, 2006) |
| "Gentamicin treated rats exhibited a 63% increase in blood urea nitrogen (BUN), a 124% increase in uric acid, and a 63% decrease in serum potassium levels on day 15." | 1.29 | Nephrotoxicity of gentamicin and co-trimoxazole combination in rats. ( Ayça, B; Cevikbaş, U; Izzettin, FV; Stohs, SJ; Uras, F; Uysal, V; Yardimci, T, 1994) |
| "Treatment with uric acid, at doses of 50, 100 or 300 mg/kg body weight, by gavage, provided some measure of protection against all of these effects, and the protection was generally dose dependent." | 1.28 | A study of uric acid pretreatment for the protection of rat gastric mucosa against toxic damage. ( Afal, M; Ahmed, MM; al-Bekairi, AM; Qureshi, S; Shah, AH, 1992) |
| "Generalized osteoarthrosis was found to be significantly more common in older males with high than with low diastolic blood pressure." | 1.25 | Hypertension in relation to musculoskeletal disorders. ( Lawrence, JS, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (42.55) | 18.7374 |
| 1990's | 6 (12.77) | 18.2507 |
| 2000's | 7 (14.89) | 29.6817 |
| 2010's | 11 (23.40) | 24.3611 |
| 2020's | 3 (6.38) | 2.80 |
| Authors | Studies |
|---|---|
| Farooq, M | 1 |
| Khan, AA | 1 |
| Fautrel, B | 1 |
| Belhassen, M | 1 |
| Hudry, C | 1 |
| Woronoff-Lemsi, MC | 1 |
| Levy-Bachelot, L | 1 |
| Van Ganse, E | 1 |
| Tubach, F | 1 |
| Zhong, CS | 1 |
| Zeng, B | 1 |
| Qiu, JH | 1 |
| Xu, LH | 1 |
| Zhong, MY | 1 |
| Huang, YT | 1 |
| Xu, R | 1 |
| Liu, SY | 1 |
| Zha, QB | 1 |
| Hu, B | 1 |
| Ou-Yang, DY | 1 |
| He, XH | 1 |
| Desai, J | 3 |
| Foresto-Neto, O | 2 |
| Honarpisheh, M | 2 |
| Steiger, S | 2 |
| Nakazawa, D | 1 |
| Popper, B | 3 |
| Buhl, EM | 1 |
| Boor, P | 2 |
| Mulay, SR | 3 |
| Anders, HJ | 3 |
| Gómez, LA | 1 |
| Poornima, K | 1 |
| Chella Perumal, P | 1 |
| Gopalakrishnan, VK | 1 |
| Kataoka, H | 1 |
| Yang, K | 1 |
| Rock, KL | 2 |
| Nasoori, A | 1 |
| Pedram, B | 1 |
| Kamyabi-Moghaddam, Z | 1 |
| Mokarizadeh, A | 1 |
| Pirasteh, H | 1 |
| Fayyaz, AF | 1 |
| Shooshtari, MB | 1 |
| Kumar, SV | 1 |
| Eberhard, JN | 1 |
| Thomasova, D | 1 |
| Romoli, S | 1 |
| Grigorescu, M | 1 |
| Kulkarni, OP | 1 |
| Vielhauer, V | 1 |
| Zuchtriegel, G | 1 |
| Reichel, C | 1 |
| Bräsen, JH | 1 |
| Romagnani, P | 1 |
| Bilyy, R | 1 |
| Munoz, LE | 1 |
| Herrmann, M | 1 |
| Liapis, H | 1 |
| Krautwald, S | 1 |
| Linkermann, A | 1 |
| Sloane, JA | 1 |
| Blitz, D | 1 |
| Margolin, Z | 1 |
| Vartanian, T | 1 |
| Kono, H | 1 |
| Chen, CJ | 1 |
| Ontiveros, F | 1 |
| Convento, MS | 1 |
| Pessoa, E | 1 |
| Dalboni, MA | 2 |
| Borges, FT | 2 |
| Schor, N | 2 |
| Michelacci, YM | 1 |
| Palani, S | 1 |
| Raja, S | 1 |
| Kumar, RP | 1 |
| Selvaraj, R | 1 |
| Kumar, BS | 1 |
| FREUDWEILER, M | 1 |
| Skoberne, M | 1 |
| Beignon, AS | 1 |
| Bhardwaj, N | 1 |
| Saxena, R | 1 |
| Loghmanee, F | 1 |
| Duarte, AI | 1 |
| Santos, MS | 1 |
| Oliveira, CR | 1 |
| Rego, AC | 1 |
| Prashanthi, N | 1 |
| Narayana, K | 1 |
| Nayanatara, A | 1 |
| Chandra Kumar, HH | 1 |
| Bairy, KL | 1 |
| D'Souza, UJ | 1 |
| Róka, A | 1 |
| Vásárhelyi, B | 1 |
| Bodrogi, E | 1 |
| Machay, T | 1 |
| Szabó, M | 1 |
| Jeremy, R | 1 |
| Orvoine, RH | 1 |
| Letellier, G | 1 |
| Lapointe, Y | 1 |
| Landolt, H | 1 |
| Langemann, H | 1 |
| Probst, A | 1 |
| Gratzl, O | 1 |
| Izzettin, FV | 1 |
| Ayça, B | 1 |
| Uras, F | 1 |
| Uysal, V | 1 |
| Cevikbaş, U | 1 |
| Yardimci, T | 1 |
| Stohs, SJ | 1 |
| Dorion, D | 1 |
| Zhong, A | 1 |
| Chiu, C | 1 |
| Forrest, CR | 1 |
| Boyd, B | 1 |
| Pang, CY | 1 |
| Iwata, J | 1 |
| Watanabe, T | 1 |
| Abe, T | 1 |
| Oda, Y | 1 |
| Kossard, S | 1 |
| Scurry, J | 1 |
| Killingsworth, M | 1 |
| Butler, RC | 1 |
| Shah, SM | 1 |
| Grunow, WA | 1 |
| Texter, C | 1 |
| Knochel, JP | 1 |
| Lawrence, JS | 1 |
| al-Bekairi, AM | 1 |
| Qureshi, S | 1 |
| Ahmed, MM | 1 |
| Afal, M | 1 |
| Shah, AH | 1 |
| Numabe, A | 1 |
| Tsukada, H | 1 |
| Sugimoto, T | 1 |
| Ono, H | 1 |
| Hirao, S | 1 |
| Abe, M | 1 |
| Yagi, S | 1 |
| Müller-Schweinitzer, E | 1 |
| Maldyk, E | 1 |
| Kawenoki-Minc, E | 1 |
| Polowiec, Z | 1 |
| Wagner, T | 1 |
| Zsernaviczky, J | 1 |
| von Torklus, D | 2 |
| Wilke, H | 2 |
| Frahm, H | 2 |
| Viala, JJ | 1 |
| Marcellin, J | 1 |
| Dechavanne, M | 1 |
| Druget, M | 1 |
| Scott, HW | 1 |
| Dean, R | 1 |
| Shull, HJ | 1 |
| Abram, HS | 1 |
| Webb, W | 1 |
| Younger, RK | 1 |
| Brill, AB | 1 |
| Stavric, B | 1 |
| Nera, EA | 1 |
| Johnson, WJ | 1 |
| Salem, FA | 1 |
| Quigley, MM | 1 |
| Espinoza, LR | 1 |
| Spilberg, I | 1 |
| Osterland, CK | 1 |
| Zsernaviezky, J | 1 |
| McCollum, DE | 1 |
| Mathews, RS | 1 |
| O'NEIL, MT | 1 |
| Boettcher, WG | 1 |
| Bonfiglio, M | 1 |
| Hamilton, HH | 1 |
| Sheets, RF | 1 |
| Smith, K | 1 |
| Frenkel, G | 1 |
| Kraicer, PF | 1 |
| Munsat, TL | 1 |
| Klinenberg, J | 1 |
| Carell, RE | 1 |
| Menkes, J | 1 |
| Hunder, GG | 1 |
| Worthington, JW | 1 |
| Bickel, WH | 1 |
4 reviews available for uric acid and Necrosis
| Article | Year |
|---|---|
A clear and present danger: endogenous ligands of Toll-like receptors.
Topics: Apoptosis; Central Nervous System; Central Nervous System Diseases; Extracellular Matrix; Heat-Shock | 2010 |
Danger signals: a time and space continuum.
Topics: Animals; Apoptosis; Cell Differentiation; Dendritic Cells; Humans; Immune Tolerance; Immunity, Innat | 2004 |
[Hyperuricemia in hematological disorders].
Topics: Bone Marrow; Bone Marrow Diseases; Hematologic Diseases; Humans; Kidney Diseases; Necrosis; Tumor Ly | 1996 |
Renal injury in mu.
Topics: Acute Kidney Injury; Adult; Animals; Glomerular Filtration Rate; Hemodynamics; Humans; Hypokalemia; | 1976 |
2 trials available for uric acid and Necrosis
| Article | Year |
|---|---|
Changes in laboratory parameters indicating cell necrosis and organ dysfunction in asphyxiated neonates on moderate systemic hypothermia.
Topics: Alanine Transaminase; Area Under Curve; Aspartate Aminotransferases; Asphyxia Neonatorum; Biomarkers | 2007 |
[Letter: Rise in blood levels in uric acid and of lacticodehydrogenase, cellular lysis, and aggraviation of certain hemopathies].
Topics: Bone Marrow Examination; Clinical Trials as Topic; Humans; L-Lactate Dehydrogenase; Leukemia, Lympho | 1974 |
41 other studies available for uric acid and Necrosis
| Article | Year |
|---|---|
Evaluation of histo-toxicity of nimesulide in Black Kites (Milvus migrans): a pharmacodynamic study.
Topics: Adult; Animals; Birds; Body Weight; Humans; Male; Necrosis; Raptors; Uric Acid | 2023 |
Predictive factors of tumour necrosis inhibitor treatment persistence for rheumatoid arthritis: An observational study in 8052 patients.
Topics: Aged; Arthritis, Rheumatoid; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Necrosis; N | 2020 |
Gout-associated monosodium urate crystal-induced necrosis is independent of NLRP3 activity but can be suppressed by combined inhibitors for multiple signaling pathways.
Topics: Animals; Arthritis, Gouty; Gout; Inflammasomes; Interleukin-1beta; Mice; Necrosis; NLR Family, Pyrin | 2022 |
Particles of different sizes and shapes induce neutrophil necroptosis followed by the release of neutrophil extracellular trap-like chromatin.
Topics: Animals; Calcium Oxalate; Calcium Phosphates; Cell Death; Cholesterol; Chromatin; Extracellular Trap | 2017 |
Phagocytosis of environmental or metabolic crystalline particles induces cytotoxicity by triggering necroptosis across a broad range of particle size and shape.
Topics: Animals; Apoptosis; Calcium Oxalate; Calcium Phosphates; Cell Line; Cholesterol; Crystallization; Cy | 2017 |
Protective effect of ethanolic extract of Tabernaemontana divaricata (L.) R. Br. against DEN and Fe NTA induced liver necrosis in Wistar Albino rats.
Topics: Alkylating Agents; Animals; Antimetabolites; Antioxidants; Bilirubin; Biomarkers; Carcinogens; Chemi | 2014 |
The xanthine oxidase inhibitor Febuxostat reduces tissue uric acid content and inhibits injury-induced inflammation in the liver and lung.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Death; Chemical and Drug Induced Liver Injury | 2015 |
Clinicopathologic characterization of visceral gout of various internal organs--a study of 2 cases from a venom and toxin research center.
Topics: Animals; Animals, Laboratory; Autopsy; Biopsy; Cause of Death; Crystallization; Elapidae; Gout; Gran | 2015 |
Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis.
Topics: Animals; Apoptosis; Calcium Oxalate; Calcium Pyrophosphate; Humans; Kidney Diseases; Mice; Mice, Inb | 2016 |
Uric acid promotes an acute inflammatory response to sterile cell death in mice.
Topics: Animals; Cell Death; Cells; Immune System; Inflammation; Mice; Mice, Inbred C57BL; Mice, Inbred Stra | 2010 |
Pro-inflammatory and oxidative effects of noncrystalline uric acid in human mesangial cells: contribution to hyperuricemic glomerular damage.
Topics: Cell Line, Transformed; Cell Survival; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Dose-Respons | 2011 |
Noncrystalline uric acid inhibits proteoglycan and glycosaminoglycan synthesis in distal tubular epithelial cells (MDCK).
Topics: Animals; Apoptosis; Cell Line; Cyclooxygenase 2; Dinoprostone; Dogs; Electrophoresis, Agar Gel; Endo | 2010 |
Evaluation of phytoconstituents and anti-nephrotoxic and antioxidant activities of Monochoria vaginalis.
Topics: Acetaminophen; Animals; Antioxidants; Creatine; Disease Models, Animal; Ethanol; Kidney Diseases; Ma | 2011 |
EXPERIMENTAL INVESTIGATIONS INTO THE ORIGIN OF GOUTY TOPHI.
Topics: Animals; Gout; History; Humans; Inflammation; Necrosis; Pathology; Poultry; Rabbits; Research; Uric | 1965 |
Fatal drug reaction due to allopurinol therapy in a 72-year-old man.
Topics: Aged; Allopurinol; Epidermis; Fatal Outcome; Gout Suppressants; Humans; Kidney Failure, Chronic; Mal | 2005 |
Insulin neuroprotection against oxidative stress in cortical neurons--involvement of uric acid and glutathione antioxidant defenses.
Topics: Aldehydes; Animals; Apoptosis; Ascorbic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Femal | 2005 |
The reproductive toxicity of the organophosphate pesticide 0, 0-dimethyl 0-4-nitrophenyl phosphorothioate (methyl parathion) in the male rat.
Topics: Acid Phosphatase; Animals; Cholesterol; Dose-Response Relationship, Drug; Epididymis; Insecticides; | 2006 |
Non-traumatic aseptic necrosis of the femoral head.
Topics: Adrenal Cortex Hormones; Adult; Alcoholism; Fats; Female; Femoral Fractures; Femur Head; Gout; Hip D | 1967 |
Systemic tolerance of osmotically induced oncolysis in rats.
Topics: Animals; Aspartate Aminotransferases; Body Weight; Diuresis; Drinking; Eating; Female; Fructose; Glu | 1983 |
Levels of water-soluble antioxidants in astrocytoma and in adjacent tumor-free tissue.
Topics: Adult; Aged; Antioxidants; Artifacts; Ascorbic Acid; Astrocytoma; Biopsy; Brain Chemistry; Brain Ede | 1994 |
Nephrotoxicity of gentamicin and co-trimoxazole combination in rats.
Topics: Animals; Blood Urea Nitrogen; Drug Therapy, Combination; Gentamicins; Kidney; Necrosis; Potassium; R | 1994 |
Role of xanthine oxidase in reperfusion injury of ischemic skeletal muscles in the pig and human.
Topics: Adult; Allopurinol; Animals; Blood Cell Count; Chromatography, High Pressure Liquid; Female; Humans; | 1993 |
Exercise-induced acute renal failure in a patient with renal hypouricemia.
Topics: Acute Kidney Injury; Child; Creatinine; Exercise; Follow-Up Studies; Humans; Kidney; Kidney Tubules; | 2000 |
Necrotizing infundibular crystalline folliculitis.
Topics: Adult; Crystallization; Facial Dermatoses; Female; Folliculitis; Humans; Necrosis; Uric Acid | 2001 |
Massive hepatic necrosis in a patient receiving allopurinol.
Topics: Allopurinol; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Humans; Middle A | 1977 |
Hypertension in relation to musculoskeletal disorders.
Topics: Blood Pressure; Cholesterol; Female; Humans; Hypertension; Intervertebral Disc; Knee Joint; Male; Ne | 1975 |
A study of uric acid pretreatment for the protection of rat gastric mucosa against toxic damage.
Topics: Animals; DNA; Dose-Response Relationship, Drug; Ethanol; Gastric Mucosa; Male; Mucus; Necrosis; Prot | 1992 |
[A case of acute renal failure in a patient with idiopathic hypouricemia].
Topics: Acute Kidney Injury; Adolescent; Humans; Kidney Tubules; Male; Necrosis; Uric Acid | 1992 |
[Diagnosis and etiology of aseptic femoral head necrosis in adults].
Topics: Adult; Age Factors; Alcoholism; Arthritis; Bone Diseases; Cortisone; Female; Femur Head; Follow-Up S | 1970 |
Microscopic appearance and histogenesis of gouty tophus.
Topics: Connective Tissue; Crystallization; Ear; Extremities; Glycosaminoglycans; Gout; Humans; Necrosis; Sk | 1972 |
[Multiple osteonecrosis with type IV hyperlipoproteinemia (author's transl)].
Topics: Adult; Blood Protein Disorders; Bone Diseases; Glucose Tolerance Test; Gout; Hip Joint; Humans; Hype | 1974 |
Considerations in use of jejunoileal bypass in patients with morbid obesity.
Topics: Adolescent; Adult; Alkaline Phosphatase; Ascorbic Acid; Aspartate Aminotransferases; Bilirubin; Caro | 1973 |
Uric acid kidney stones induced in rats by oxonic acid, a uricase inhibitor.
Topics: Animals; Blood Urea Nitrogen; Body Weight; Epithelial Cells; Kidney; Kidney Calculi; Kidney Cortex; | 1973 |
Acute obstetric yellow atrophy presenting as idiopathic hyperuricemia.
Topics: Acute Kidney Injury; Adult; Blood Coagulation Tests; Bronchopneumonia; Cytoplasm; Diagnosis, Differe | 1974 |
Joint manifestations of sickle cell disease.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Arthritis; Bone and Bones; Child; Child, Preschool; Erythroc | 1974 |
[Multiple aseptic bone necrosis in hyperlipidaemia, hyperuricaemia, and latent diabetes mellitus (author's transl)].
Topics: Adult; Allopurinol; Bone Diseases; Clofibrate; Diet Therapy; Dietary Carbohydrates; Femur Head Necro | 1974 |
Aseptic necrosis of the femoral head: associated diseases and evaluation of treatment.
Topics: Adult; Age Factors; Anemia, Sickle Cell; Bone Diseases; Female; Femoral Fractures; Femur Head; Fluor | 1970 |
Non-traumatic necrosis of the femoral head. I. Relation of altered hemostasis to etiology.
Topics: Alcohol Drinking; Blood Coagulation Disorders; Blood Coagulation Tests; Blood Platelet Disorders; Fe | 1970 |
The inhibition of adrenocortical function in the lizard Agama stellio.
Topics: Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Glands; Animals; Blood Glucose; Depression, | 1971 |
Defects in purine metabolism and neurologic disease.
Topics: Brain; Cerebellum; Child; Glucosyltransferases; Gout; Hemorrhage; Humans; Male; Necrosis; Nervous Sy | 1968 |
Avascular necrosis of the femoral head in a patient with gout.
Topics: Adult; Amputation, Surgical; Bone Diseases; Femur Head; Gout; Hip Joint; Humans; Male; Necrosis; Rad | 1968 |