Proteins > Oxygen-insensitive NAD(P)H nitroreductase
Page last updated: 2024-08-07 13:15:57
Oxygen-insensitive NAD(P)H nitroreductase
An oxygen-insensitive NAD(P)H nitroreductase that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P38489]
Synonyms
EC 1.-.-.-;
Dihydropteridine reductase;
1.5.1.34;
FMN-dependent nitroreductase
Research
Bioassay Publications (3)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
Compounds (3)
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| tretazicar | Escherichia coli K-12 | Km | 7,627.0000 | 3 | 3 |
| sn 23862 | Escherichia coli K-12 | Km | 2,500.0000 | 2 | 2 |
| pr-104a | Escherichia coli K-12 | Km | 4,500.0000 | 2 | 2 |
Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer.European journal of medicinal chemistry, , Feb-01, Volume: 187, 2020
PRODRUGS FOR NITROREDUCTASE BASED CANCER THERAPY- 2: Novel amide/Ntr combinations targeting PC3 cancer cells.European journal of medicinal chemistry, , Jun-01, Volume: 171, 2019
Design, synthesis, and biological evaluation of cyclic and acyclic nitrobenzylphosphoramide mustards for E. coli nitroreductase activation.Journal of medicinal chemistry, , Jul-13, Volume: 49, Issue:14, 2006