Protein mono-ADP-ribosyltransferase PARP15

A protein mono-ADP-ribosyltransferase PARP15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q460N3]

EC 2.4.2.-;
ADP-ribosyltransferase diphtheria toxin-like 7;
ARTD7;
B-aggressive lymphoma protein 3;
Poly [ADP-ribose] polymerase 15;
PARP-15

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
adenine	Homo sapiens (human)	IC50	15.0000	1	0
niacinamide	Homo sapiens (human)	IC50	15.0000	1	0
1,5-dihydroxyisoquinoline	Homo sapiens (human)	IC50	6.6048	1	0
phenanthridone	Homo sapiens (human)	IC50	2.4559	1	0
pj-34	Homo sapiens (human)	IC50	8.9563	1	2
4-Methoxybenzamide	Homo sapiens (human)	IC50	10.0000	1	1
rucaparib	Homo sapiens (human)	IC50	32.4797	1	2
olaparib	Homo sapiens (human)	IC50	12.6565	2	2
niraparib	Homo sapiens (human)	IC50	29.0202	1	2
minocycline	Homo sapiens (human)	IC50	15.0000	1	0
xav939	Homo sapiens (human)	IC50	15.0000	1	0

This protein enables 6 target(s):

Target	Category	Definition
transcription corepressor activity	molecular function	A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]
NAD+ ADP-ribosyltransferase activity	molecular function	Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. [EC:2.4.2.30]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
nucleotidyltransferase activity	molecular function	Catalysis of the transfer of a nucleotidyl group to a reactant. [ISBN:0198506732]
NAD+ binding	molecular function	Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. [GOC:mah]
NAD+-protein ADP-ribosyltransferase activity	molecular function	Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide. [PMID:1899243]

This protein is located in 1 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

This protein is active in 2 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

This protein is involved in 3 target(s):

Target	Category	Definition
negative regulation of transcription by RNA polymerase II	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
protein poly-ADP-ribosylation	biological process	The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain. [GOC:BHF, GOC:mah, GOC:rl, PMID:25043379]
negative regulation of gene expression	biological process	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]