Mitogen-activated protein kinase 14

A mitogen-activated protein kinase 14 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q16539]

Synonyms

MAP kinase 14;
MAPK 14;
EC 2.7.11.24;
Cytokine suppressive anti-inflammatory drug-binding protein;
CSAID-binding protein;
CSBP;
MAP kinase MXI2;
MAX-interacting protein 2;
Mitogen-activated protein kinase p38 alpha;
MA

Research

Bioassay Publications (217)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	7 (3.23)	18.2507
2000's	103 (47.47)	29.6817
2010's	96 (44.24)	24.3611
2020's	11 (5.07)	2.80

Compounds (366)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
1-anilino-8-naphthalenesulfonate	Homo sapiens (human)	IC50	1.2000	1	1
rtki cpd	Homo sapiens (human)	IC50	0.5600	1	1
benzbromarone	Homo sapiens (human)	IC50	1.2350	1	0
bithionol	Homo sapiens (human)	IC50	0.3180	1	0
celecoxib	Homo sapiens (human)	IC50	0.8100	1	1
fenbendazole	Homo sapiens (human)	IC50	3.1880	1	0
hexachlorophene	Homo sapiens (human)	IC50	0.0876	1	0
iodoquinol	Homo sapiens (human)	IC50	0.3640	1	0
kynurenic acid	Homo sapiens (human)	Ki	1,300.0000	1	1
olomoucine	Homo sapiens (human)	IC50	63.5000	1	2
pd 153035	Homo sapiens (human)	IC50	6.3000	1	1
pd 169316	Homo sapiens (human)	IC50	0.0890	1	1
ag 1879	Homo sapiens (human)	IC50	4.2300	1	1
sb 220025	Homo sapiens (human)	IC50	2.5880	6	7
sb 239063	Homo sapiens (human)	IC50	0.0415	4	4
sb 202190	Homo sapiens (human)	IC50	0.0625	17	17
sb 216995	Homo sapiens (human)	IC50	16.7657	5	6
sk&f 86002	Homo sapiens (human)	IC50	2.1217	5	6
imatinib	Homo sapiens (human)	IC50	61.2333	3	3
ici 204,219	Homo sapiens (human)	IC50	0.3530	1	0
zm 336372	Homo sapiens (human)	IC50	1.0900	2	2
pyrazolanthrone	Homo sapiens (human)	IC50	15.0750	1	2
3,3',4',5-tetrachlorosalicylanilide	Homo sapiens (human)	IC50	2.1760	1	0
tribromsalan	Homo sapiens (human)	IC50	0.7150	1	0
4-octylphenol	Homo sapiens (human)	IC50	15.0160	1	0
nafenopin	Homo sapiens (human)	IC50	3.7405	1	0
pirfenidone	Homo sapiens (human)	IC50	165.4000	1	1
closantel	Homo sapiens (human)	IC50	0.6560	1	0
staurosporine	Homo sapiens (human)	IC50	0.5052	2	2
mifepristone	Homo sapiens (human)	IC50	83.0610	1	0
nelfinavir	Homo sapiens (human)	IC50	18.2240	1	0
3,4-dihydro-2(1h)-quinolinone	Homo sapiens (human)	IC50	0.0007	2	2
epigallocatechin gallate	Homo sapiens (human)	IC50	2.2100	1	1
gallocatechol	Homo sapiens (human)	IC50	4.4150	1	2
cephalotaxine	Homo sapiens (human)	IC50	0.2000	1	1
epicatechin	Homo sapiens (human)	IC50	78.5500	1	2
hesperetin	Homo sapiens (human)	IC50	54.6000	1	1
u 74006f	Homo sapiens (human)	IC50	7.4060	1	0
epicatechin gallate	Homo sapiens (human)	IC50	1.4700	1	1
mk 0663	Homo sapiens (human)	IC50	0.5300	1	1
perifosine	Homo sapiens (human)	IC50	1.2000	1	1
birb 796	Homo sapiens (human)	IC50	0.0674	18	18
birb 796	Homo sapiens (human)	Ki	0.0186	4	4
nevadensin	Homo sapiens (human)	IC50	20.1000	1	2
sb 203580	Homo sapiens (human)	IC50	15.3271	73	75
sb 203580	Homo sapiens (human)	Ki	0.0375	2	2
4'-o-methylepigallocatechin	Homo sapiens (human)	IC50	39.1600	1	1
sorafenib	Homo sapiens (human)	IC50	0.6228	8	8
1-phenyl-3-methyl-4-benzoyl-5-pyrazolone	Homo sapiens (human)	IC50	100.0000	2	2
1-(3-tert-butyl-1-methylpyrazol-5-yl)-3-(4-chlorophenyl)urea	Homo sapiens (human)	IC50	12.8648	3	3
pd 166326	Homo sapiens (human)	IC50	0.1400	1	1
hts 466284	Homo sapiens (human)	IC50	25.8700	2	2
diethylstilbestrol	Homo sapiens (human)	IC50	32.9030	1	0
repsox	Homo sapiens (human)	IC50	16.0000	1	1
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-1-naphthalenecarboxamide	Homo sapiens (human)	IC50	15.8489	1	1
dieldrin	Homo sapiens (human)	IC50	43.1930	1	0
u 0126	Homo sapiens (human)	IC50	55.0000	1	1
rwj 67657	Homo sapiens (human)	IC50	1.0000	1	1
vx-745	Homo sapiens (human)	IC50	1.8567	15	16
vx-745	Homo sapiens (human)	Ki	0.0008	1	1
dasatinib	Homo sapiens (human)	IC50	0.1000	3	3
quercetin	Homo sapiens (human)	IC50	2.8800	1	2
3,7-dimethoxy-5,3',4'-trihydroxyflavone	Homo sapiens (human)	IC50	10.0000	1	2
acacetin	Homo sapiens (human)	IC50	27.8900	1	2
apigenin	Homo sapiens (human)	IC50	10.2667	1	3
luteolin	Homo sapiens (human)	IC50	10.1500	1	2
quercitrin	Homo sapiens (human)	IC50	24.1500	1	2
luteolin-7-glucoside	Homo sapiens (human)	IC50	44.7750	1	2
chrysoeriol	Homo sapiens (human)	IC50	33.6000	1	1
quercetin 3-o-glucopyranoside	Homo sapiens (human)	IC50	41.4333	1	3
rutin	Homo sapiens (human)	IC50	65.9000	1	1
kaempferol	Homo sapiens (human)	IC50	18.7500	1	2
genistein	Homo sapiens (human)	IC50	61.4000	1	1
montelukast	Homo sapiens (human)	IC50	0.8560	1	0
apigenin dimethylether	Homo sapiens (human)	IC50	27.8000	1	1
chrysin	Homo sapiens (human)	IC50	25.8500	1	2
diosmetin	Homo sapiens (human)	IC50	25.9000	1	2
fisetin	Homo sapiens (human)	IC50	2.6500	1	2
hispidulin	Homo sapiens (human)	IC50	26.7000	1	2
3-methylquercetin	Homo sapiens (human)	IC50	13.2000	1	2
kaempferide	Homo sapiens (human)	IC50	42.7000	1	2
morin	Homo sapiens (human)	IC50	19.1000	1	2
myricetin	Homo sapiens (human)	IC50	1.9400	1	2
orientin	Homo sapiens (human)	IC50	46.9500	1	2
patuletin	Homo sapiens (human)	IC50	38.6000	1	2
isotretinoin	Homo sapiens (human)	IC50	2.5290	1	0
kn 93	Homo sapiens (human)	IC50	100.0000	1	1
ombuine	Homo sapiens (human)	IC50	29.6900	1	2
5,7-dihydroxy-4',6-dimethoxyflavone	Homo sapiens (human)	IC50	32.4000	1	1
jaceosidin	Homo sapiens (human)	IC50	19.0000	1	2
5,4'-dihydroxy-7,3'-dimethoxyflavone	Homo sapiens (human)	IC50	30.1500	1	2
2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz(h)imidazo(4,5-f)isoquinoline-7-one	Homo sapiens (human)	IC50	11.0000	1	1
ml 3403	Homo sapiens (human)	IC50	0.7748	6	6
d 4476	Homo sapiens (human)	IC50	8.4885	4	4
cyc 116	Homo sapiens (human)	Ki	10.0000	1	1
4-[4-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-1H-imidazol-5-yl]pyridine	Homo sapiens (human)	IC50	0.0400	1	1
a 770041	Homo sapiens (human)	IC50	25.0000	1	1
vk 19911	Homo sapiens (human)	IC50	0.1009	7	7
vk 19911	Homo sapiens (human)	Ki	0.0600	1	1
[4-(2-amino-4-bromoanilino)-2-chlorophenyl]-(2-methylphenyl)methanone	Homo sapiens (human)	IC50	0.0282	6	6
rwj 68354	Homo sapiens (human)	IC50	0.0385	5	4
gw843682x	Homo sapiens (human)	IC50	15.0000	1	1
sb-505124	Homo sapiens (human)	IC50	0.6072	5	5
sb 242235	Homo sapiens (human)	IC50	0.0572	4	4
sb 242235	Homo sapiens (human)	Ki	0.0360	1	1
sd 0006	Homo sapiens (human)	IC50	0.1100	1	1
scio-469	Homo sapiens (human)	IC50	0.0320	5	5
sb 210313	Homo sapiens (human)	IC50	0.9067	3	3
3,5-bis(2-fluorobenzylidene)piperidin-4-one	Homo sapiens (human)	IC50	92.0000	1	1
ct52923	Homo sapiens (human)	IC50	30.0000	1	1
tofacitinib	Homo sapiens (human)	IC50	10.0000	1	1
4-n-butyl-1-(4-(2-methylphenyl)-4-oxo-1-butyl)-piperidine hydrogen chloride	Homo sapiens (human)	Ki	1.0000	1	1
tak-715	Homo sapiens (human)	IC50	0.1236	4	4
ly2090314	Homo sapiens (human)	IC50	20.0000	1	1
ly-2157299	Homo sapiens (human)	IC50	0.4736	5	5
N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide	Homo sapiens (human)	IC50	1.5000	3	3
N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide	Homo sapiens (human)	Ki	0.7771	6	7
gw 799388	Homo sapiens (human)	IC50	7.2800	1	1
sotrastaurin	Homo sapiens (human)	IC50	10.0000	1	1
ps 540446	Homo sapiens (human)	IC50	0.0130	2	2
pha 665752	Homo sapiens (human)	IC50	10.0000	1	1
l 783277	Homo sapiens (human)	IC50	10.0000	1	1
r 1487	Homo sapiens (human)	IC50	0.0100	1	1
danusertib	Homo sapiens (human)	IC50	10.0000	1	1
nvp-aew541	Homo sapiens (human)	IC50	10.0000	1	1
fr 180204	Homo sapiens (human)	Ki	0.3100	1	1
6-(5-((cyclopropylamino)carbonyl)-3-fluoro-2-methylphenyl)-n-(2,2-dimethylprpyl)-3-pyridinecarboxamide	Homo sapiens (human)	IC50	0.1000	1	1
6-(5-((cyclopropylamino)carbonyl)-3-fluoro-2-methylphenyl)-n-(2,2-dimethylprpyl)-3-pyridinecarboxamide	Homo sapiens (human)	Ki	0.0217	3	4
cc-930	Homo sapiens (human)	IC50	3.4000	2	2
gw 2580	Homo sapiens (human)	IC50	16.0000	1	1
tak 285	Homo sapiens (human)	IC50	10.0000	1	1
crizotinib	Homo sapiens (human)	IC50	10.0000	1	1
5-(5,6-dimethoxy-1-benzimidazolyl)-3-[(2-methylsulfonylphenyl)methoxy]-2-thiophenecarbonitrile	Homo sapiens (human)	IC50	15.8489	1	1
4-[2-(2-chloro-4-fluoroanilino)-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide	Homo sapiens (human)	Ki	4.0000	1	1
motesanib	Homo sapiens (human)	IC50	1.0880	1	11
in 1130	Homo sapiens (human)	IC50	1.1167	6	6
4-(3-cyclohexyl-5-(4-fluoro-phenyl)-3h-imidazol-4-yl)pyrimidin-2-ylamine	Homo sapiens (human)	IC50	0.1146	2	2
5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine	Homo sapiens (human)	IC50	100.0000	1	1
N-(2,4-dimethoxyphenyl)-N-[2-[4-(4-methyl-1-piperazinyl)anilino]-4-pyrimidinyl]carbamic acid (2,6-dimethylphenyl) ester	Homo sapiens (human)	IC50	0.6496	2	5
azd 1152-hqpa	Homo sapiens (human)	Ki	10.0000	1	1
2-({2-[(3-hydroxyphenyl)amino]pyrimidin-4-yl}amino)benzamide	Homo sapiens (human)	IC50	50.0000	1	1
4-methyl-3-(2-(2-morpholinoethylamino)quinazolin-6-yl)-n-(3-(trifluoromethyl)phenyl)benzamide	Homo sapiens (human)	IC50	0.0030	1	1
tannins	Homo sapiens (human)	IC50	0.3750	1	0
pamapimod	Homo sapiens (human)	IC50	0.0140	2	2
pha 848125	Homo sapiens (human)	IC50	10.0000	1	1
ph 797804	Homo sapiens (human)	IC50	0.0460	4	6
ph 797804	Homo sapiens (human)	Ki	0.0044	2	2
amg 458	Homo sapiens (human)	IC50	100.0000	1	1
arry-614	Homo sapiens (human)	IC50	0.0040	1	1
bms 777607	Homo sapiens (human)	IC50	2.0000	1	1
ponatinib	Homo sapiens (human)	IC50	0.0100	1	1
N-cyclopropyl-3-{4-[(cyclopropylmethyl)carbamoyl]phenyl}-4-methylbenzamide	Homo sapiens (human)	IC50	0.0919	4	4
N-cyclopropyl-3-{4-[(cyclopropylmethyl)carbamoyl]phenyl}-4-methylbenzamide	Homo sapiens (human)	Ki	0.0115	6	7
N-(2,6-difluorophenyl)-5-[3-[2-[5-ethyl-2-methoxy-4-[4-(4-methylsulfonyl-1-piperazinyl)-1-piperidinyl]anilino]-4-pyrimidinyl]-2-imidazo[1,2-a]pyridinyl]-2-methoxybenzamide	Homo sapiens (human)	IC50	11.0000	1	1
entrectinib	Homo sapiens (human)	IC50	10.0000	1	1
4-[6-[4-(methoxycarbonylamino)phenyl]-4-(4-morpholinyl)-1-pyrazolo[3,4-d]pyrimidinyl]-1-piperidinecarboxylic acid methyl ester	Homo sapiens (human)	IC50	50.0000	1	1
skepinone-l	Homo sapiens (human)	IC50	0.0091	8	4
pha 793887	Homo sapiens (human)	IC50	10.0000	1	1
tak-632	Homo sapiens (human)	IC50	0.6000	1	1
3-((4-(6-methylpyridin-2-yl)-5-(quinolin-6-yl)-1h-imidazol-2-yl)methyl)benzamide	Homo sapiens (human)	IC50	0.5400	1	1
arry-371797	Homo sapiens (human)	IC50	0.0045	1	1
nms p937	Homo sapiens (human)	IC50	10.0000	1	1
nms-p118	Homo sapiens (human)	IC50	10.0000	1	1
encorafenib	Homo sapiens (human)	IC50	2.2000	1	0
lfm a13	Homo sapiens (human)	IC50	500.0000	1	1
urmc-099	Homo sapiens (human)	IC50	12.0500	1	1
ew-7197	Homo sapiens (human)	IC50	2.3960	5	5
4-[[9-[(3R)-3-oxolanyl]-8-(2,4,6-trifluoroanilino)-2-purinyl]amino]-1-cyclohexanol	Homo sapiens (human)	IC50	3.0000	1	1
ly3009120	Homo sapiens (human)	IC50	0.0610	1	1
nms-e973	Homo sapiens (human)	IC50	0.0100	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
fasudil	Homo sapiens (human)	Kd	30.0000	1	1
4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline	Homo sapiens (human)	Kd	30.0000	1	1
sb 202190	Homo sapiens (human)	Kd	0.0114	2	2
sk&f 86002	Homo sapiens (human)	Kd	0.1800	1	1
imatinib	Homo sapiens (human)	Kd	13.2906	4	4
troglitazone	Homo sapiens (human)	EC50	1.0000	1	1
triciribine phosphate	Homo sapiens (human)	Kd	30.0000	1	1
staurosporine	Homo sapiens (human)	Kd	10.0000	2	2
picropodophyllin	Homo sapiens (human)	Kd	30.0000	1	1
gefitinib	Homo sapiens (human)	Kd	16.6667	3	3
lestaurtinib	Homo sapiens (human)	Kd	16.6667	3	3
perifosine	Homo sapiens (human)	Kd	30.0000	1	1
vatalanib	Homo sapiens (human)	Kd	16.6667	3	3
ruboxistaurin	Homo sapiens (human)	Kd	16.6667	3	3
canertinib	Homo sapiens (human)	Kd	16.6667	3	3
birb 796	Homo sapiens (human)	EC50	0.0180	1	1
birb 796	Homo sapiens (human)	Kd	0.0013	17	18
cyc 202	Homo sapiens (human)	Kd	20.0000	2	2
sb 203580	Homo sapiens (human)	EC50	0.0600	2	2
sb 203580	Homo sapiens (human)	Kd	0.0128	6	6
enzastaurin	Homo sapiens (human)	Kd	20.0000	2	2
erlotinib	Homo sapiens (human)	Kd	16.6667	3	3
lapatinib	Homo sapiens (human)	Kd	16.6667	3	3
sorafenib	Homo sapiens (human)	Kd	5.2717	6	6
1-(3-tert-butyl-1-methylpyrazol-5-yl)-3-(4-chlorophenyl)urea	Homo sapiens (human)	EC50	5.9000	1	1
1-(3-tert-butyl-1-methylpyrazol-5-yl)-3-(4-chlorophenyl)urea	Homo sapiens (human)	Kd	1.5482	10	10
pd 173955	Homo sapiens (human)	Kd	0.0670	1	1
s 1033	Homo sapiens (human)	EC50	4.6000	1	1
s 1033	Homo sapiens (human)	Kd	0.6157	3	3
xl147	Homo sapiens (human)	Kd	30.0000	1	2
bms 387032	Homo sapiens (human)	Kd	16.6667	3	3
sf 2370	Homo sapiens (human)	Kd	30.0000	1	1
tandutinib	Homo sapiens (human)	Kd	15.0000	4	4
vx-745	Homo sapiens (human)	Kd	0.0029	4	4
dasatinib	Homo sapiens (human)	EC50	0.4700	1	1
dasatinib	Homo sapiens (human)	Kd	0.3587	7	7
ha 1100	Homo sapiens (human)	Kd	30.0000	1	1
7-epi-hydroxystaurosporine	Homo sapiens (human)	Kd	30.0000	1	1
zd 6474	Homo sapiens (human)	Kd	16.6667	3	3
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide	Homo sapiens (human)	Kd	10.0000	1	1
imd 0354	Homo sapiens (human)	Kd	30.0000	1	1
sirolimus	Homo sapiens (human)	Kd	30.0000	1	1
alvocidib	Homo sapiens (human)	Kd	16.6667	3	3
bosutinib	Homo sapiens (human)	Kd	20.0000	2	2
orantinib	Homo sapiens (human)	Kd	30.0000	1	1
su 11248	Homo sapiens (human)	Kd	15.0000	4	4
palbociclib	Homo sapiens (human)	Kd	30.0000	1	1
jnj-7706621	Homo sapiens (human)	Kd	10.0000	1	1
vx680	Homo sapiens (human)	Kd	16.6667	3	3
cyc 116	Homo sapiens (human)	Kd	30.0000	1	1
everolimus	Homo sapiens (human)	Kd	30.0000	1	1
trk 820	Homo sapiens (human)	EC50	0.0052	1	1
ekb 569	Homo sapiens (human)	Kd	20.0000	2	2
axitinib	Homo sapiens (human)	Kd	20.0000	2	2
4-[4-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-1H-imidazol-5-yl]pyridine	Homo sapiens (human)	Kd	0.0110	1	1
temsirolimus	Homo sapiens (human)	Kd	30.0000	1	1
pd 184352	Homo sapiens (human)	Kd	10.0000	1	1
on 01910	Homo sapiens (human)	Kd	30.0000	1	2
vk 19911	Homo sapiens (human)	Kd	0.0135	2	2
av 412	Homo sapiens (human)	Kd	30.0000	1	1
telatinib	Homo sapiens (human)	Kd	30.0000	1	1
y-39983	Homo sapiens (human)	Kd	30.0000	1	1
cp 547632	Homo sapiens (human)	Kd	30.0000	1	1
bms345541	Homo sapiens (human)	Kd	10.0000	1	1
lenvatinib	Homo sapiens (human)	Kd	0.2170	1	1
pd 0325901	Homo sapiens (human)	Kd	30.0000	1	2
midostaurin	Homo sapiens (human)	Kd	15.0000	4	4
px-866	Homo sapiens (human)	Kd	30.0000	1	1
ripasudil	Homo sapiens (human)	Kd	30.0000	1	1
osi 930	Homo sapiens (human)	Kd	30.0000	1	1
ki 20227	Homo sapiens (human)	Kd	10.0000	1	1
scio-469	Homo sapiens (human)	Kd	0.0042	2	2
cp 724714	Homo sapiens (human)	Kd	20.0000	2	2
pi103	Homo sapiens (human)	Kd	10.0000	2	2
hmn-214	Homo sapiens (human)	Kd	30.0000	1	1
tivozanib	Homo sapiens (human)	Kd	30.0000	1	1
hki 272	Homo sapiens (human)	Kd	20.0000	2	2
tofacitinib	Homo sapiens (human)	Kd	16.6667	3	3
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamide	Homo sapiens (human)	Kd	10.0000	1	1
cediranib	Homo sapiens (human)	Kd	20.0000	2	2
masitinib	Homo sapiens (human)	Kd	20.0000	2	2
ly-2157299	Homo sapiens (human)	Kd	30.0000	1	1
pazopanib	Homo sapiens (human)	Kd	16.6667	3	3
azd 6244	Homo sapiens (human)	Kd	20.0000	2	2
su 14813	Homo sapiens (human)	Kd	16.6667	3	3
bibw 2992	Homo sapiens (human)	Kd	1.1735	2	2
binimetinib	Homo sapiens (human)	Kd	30.0000	1	1
sotrastaurin	Homo sapiens (human)	Kd	30.0000	1	1
aee 788	Homo sapiens (human)	Kd	30.0000	1	1
saracatinib	Homo sapiens (human)	Kd	30.0000	1	1
vx 702	Homo sapiens (human)	Kd	0.0054	2	2
crenolanib	Homo sapiens (human)	Kd	30.0000	1	1
tg100-115	Homo sapiens (human)	Kd	20.0000	2	2
cc 401	Homo sapiens (human)	Kd	30.0000	1	1
bms 599626	Homo sapiens (human)	Kd	30.0000	1	1
exel-7647	Homo sapiens (human)	Kd	30.0000	1	1
volasertib	Homo sapiens (human)	Kd	30.0000	1	2
pha 665752	Homo sapiens (human)	Kd	10.0000	1	1
azd 7762	Homo sapiens (human)	Kd	30.0000	1	1
regorafenib	Homo sapiens (human)	Kd	0.7050	1	1
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one	Homo sapiens (human)	Kd	20.0000	2	2
brivanib	Homo sapiens (human)	Kd	20.0000	2	2
mp470	Homo sapiens (human)	Kd	30.0000	1	1
rgb 286638	Homo sapiens (human)	Kd	30.0000	1	1
np 031112	Homo sapiens (human)	Kd	30.0000	1	1
at 7519	Homo sapiens (human)	Kd	20.0000	2	2
bms-690514	Homo sapiens (human)	Kd	30.0000	1	1
bi 2536	Homo sapiens (human)	Kd	20.0000	2	2
inno-406	Homo sapiens (human)	Kd	0.5360	1	1
r 1487	Homo sapiens (human)	Kd	0.0002	1	1
nvp-ast487	Homo sapiens (human)	Kd	0.0730	2	2
kw 2449	Homo sapiens (human)	Kd	20.0000	2	2
danusertib	Homo sapiens (human)	Kd	30.0000	1	1
abt 869	Homo sapiens (human)	Kd	16.6667	3	3
azd 8931	Homo sapiens (human)	Kd	30.0000	1	1
arq 197	Homo sapiens (human)	Kd	30.0000	1	1
azd 1152	Homo sapiens (human)	Kd	30.0000	1	2
pf 00299804	Homo sapiens (human)	Kd	30.0000	1	1
ridaforolimus	Homo sapiens (human)	Kd	30.0000	1	1
ch 4987655	Homo sapiens (human)	Kd	30.0000	1	1
6-(5-((cyclopropylamino)carbonyl)-3-fluoro-2-methylphenyl)-n-(2,2-dimethylprpyl)-3-pyridinecarboxamide	Homo sapiens (human)	Kd	0.0090	1	1
cc-930	Homo sapiens (human)	Kd	0.7290	1	1
gw 2580	Homo sapiens (human)	Kd	10.0000	2	2
tak 285	Homo sapiens (human)	Kd	30.0000	1	1
idelalisib	Homo sapiens (human)	Kd	30.0000	1	1
crizotinib	Homo sapiens (human)	Kd	20.0000	2	2
osi 906	Homo sapiens (human)	Kd	30.0000	1	1
chir-265	Homo sapiens (human)	Kd	16.6667	3	3
motesanib	Homo sapiens (human)	Kd	16.6667	3	3
fostamatinib	Homo sapiens (human)	Kd	30.0000	1	1
trametinib	Homo sapiens (human)	Kd	30.0000	1	1
mln8054	Homo sapiens (human)	Kd	16.6667	3	3
pf-562,271	Homo sapiens (human)	Kd	30.0000	1	2
GDC-0879	Homo sapiens (human)	Kd	10.0000	1	1
jnj-26483327	Homo sapiens (human)	Kd	30.0000	1	1
ly2603618	Homo sapiens (human)	Kd	30.0000	1	1
tg100801	Homo sapiens (human)	Kd	30.0000	1	1
dactolisib	Homo sapiens (human)	Kd	30.0000	1	2
bgt226	Homo sapiens (human)	Kd	30.0000	1	1
gsk 461364	Homo sapiens (human)	Kd	20.0000	2	2
azd 1152-hqpa	Homo sapiens (human)	Kd	16.6667	3	3
nvp-tae684	Homo sapiens (human)	Kd	10.0000	1	1
enmd 2076	Homo sapiens (human)	Kd	30.0000	1	1
e 7050	Homo sapiens (human)	Kd	1.1110	1	1
2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)-7-pyrido[2,3-d]pyrimidinone	Homo sapiens (human)	Kd	30.0000	1	1
tak-901	Homo sapiens (human)	Kd	30.0000	1	1
pamapimod	Homo sapiens (human)	Kd	0.0013	2	2
gdc-0973	Homo sapiens (human)	Kd	30.0000	1	1
buparlisib	Homo sapiens (human)	Kd	30.0000	1	1
azd 1480	Homo sapiens (human)	Kd	30.0000	1	1
azd8330	Homo sapiens (human)	Kd	30.0000	1	1
pha 848125	Homo sapiens (human)	Kd	30.0000	1	1
ro5126766	Homo sapiens (human)	Kd	30.0000	1	1
fedratinib	Homo sapiens (human)	Kd	20.0000	2	2
gsk690693	Homo sapiens (human)	Kd	20.0000	2	2
14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene	Homo sapiens (human)	Kd	30.0000	1	1
azd5438	Homo sapiens (human)	Kd	30.0000	1	1
pf 04217903	Homo sapiens (human)	Kd	30.0000	1	1
gdc 0941	Homo sapiens (human)	Kd	20.0000	2	2
icotinib	Homo sapiens (human)	Kd	30.0000	1	1
ph 797804	Homo sapiens (human)	Kd	0.0038	2	2
kx-01	Homo sapiens (human)	Kd	30.0000	1	1
plx 4720	Homo sapiens (human)	Kd	10.0000	1	1
mk 5108	Homo sapiens (human)	Kd	30.0000	1	1
cx 4945	Homo sapiens (human)	Kd	30.0000	1	1
cudc 101	Homo sapiens (human)	Kd	30.0000	1	2
arry-614	Homo sapiens (human)	Kd	0.0420	1	1
tak 593	Homo sapiens (human)	Kd	30.0000	1	1
mln 8237	Homo sapiens (human)	Kd	30.0000	1	1
sgx 523	Homo sapiens (human)	Kd	20.0000	2	2
bms 754807	Homo sapiens (human)	Kd	30.0000	1	1
bms 777607	Homo sapiens (human)	Kd	30.0000	1	1
sgi 1776	Homo sapiens (human)	Kd	30.0000	1	1
pci 32765	Homo sapiens (human)	Kd	30.0000	1	2
ponatinib	Homo sapiens (human)	Kd	0.1540	1	1
amg 900	Homo sapiens (human)	Kd	0.7350	1	1
mk-1775	Homo sapiens (human)	Kd	30.0000	1	1
AMG-208	Homo sapiens (human)	Kd	30.0000	1	1
quizartinib	Homo sapiens (human)	Kd	16.6667	3	3
at13148	Homo sapiens (human)	Kd	30.0000	1	1
tak 733	Homo sapiens (human)	Kd	30.0000	1	2
mk 2206	Homo sapiens (human)	Kd	30.0000	1	1
sns 314	Homo sapiens (human)	Kd	30.0000	1	1
lucitanib	Homo sapiens (human)	Kd	30.0000	1	1
pf-04691502	Homo sapiens (human)	Kd	30.0000	1	1
n-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide	Homo sapiens (human)	Kd	30.0000	1	1
dcc-2036	Homo sapiens (human)	Kd	2.7630	1	1
cabozantinib	Homo sapiens (human)	Kd	30.0000	1	1
defactinib	Homo sapiens (human)	Kd	30.0000	1	1
ly2584702	Homo sapiens (human)	Kd	30.0000	1	1
incb-018424	Homo sapiens (human)	Kd	20.0000	2	2
poziotinib	Homo sapiens (human)	Kd	30.0000	1	1
asp3026	Homo sapiens (human)	Kd	30.0000	1	1
entrectinib	Homo sapiens (human)	Kd	30.0000	1	1
pexidartinib	Homo sapiens (human)	Kd	30.0000	1	1
TAK-580	Homo sapiens (human)	Kd	0.3580	1	1
gsk 2126458	Homo sapiens (human)	Kd	30.0000	1	1
emd1214063	Homo sapiens (human)	Kd	30.0000	1	1
gsk 1838705a	Homo sapiens (human)	Kd	10.0000	1	1
pf 3758309	Homo sapiens (human)	Kd	30.0000	1	2
gdc 0980	Homo sapiens (human)	Kd	30.0000	1	1
azd2014	Homo sapiens (human)	Kd	30.0000	1	1
(5-(2,4-bis((3s)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol	Homo sapiens (human)	Kd	30.0000	1	1
plx4032	Homo sapiens (human)	Kd	30.0000	1	1
gsk 1363089	Homo sapiens (human)	Kd	15.1600	2	2
arry-334543	Homo sapiens (human)	Kd	30.0000	1	1
kin-193	Homo sapiens (human)	Kd	30.0000	1	1
mk 2461	Homo sapiens (human)	Kd	30.0000	1	1
bay 869766	Homo sapiens (human)	Kd	30.0000	1	1
as 703026	Homo sapiens (human)	Kd	30.0000	1	1
baricitinib	Homo sapiens (human)	Kd	30.0000	1	1
dabrafenib	Homo sapiens (human)	Kd	30.0000	1	1
pki 587	Homo sapiens (human)	Kd	30.0000	1	1
n-(3-fluoro-4-((1-methyl-6-(1h-pyrazol-4-yl)-1h-indazol-5 yl)oxy)phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide	Homo sapiens (human)	Kd	30.0000	1	1
ribociclib	Homo sapiens (human)	Kd	30.0000	1	1
mk-8033	Homo sapiens (human)	Kd	30.0000	1	1
pha 793887	Homo sapiens (human)	Kd	30.0000	1	1
sb 1518	Homo sapiens (human)	Kd	30.0000	1	1
abemaciclib	Homo sapiens (human)	Kd	30.0000	1	1
mk-8776	Homo sapiens (human)	Kd	30.0000	1	1
afuresertib	Homo sapiens (human)	Kd	30.0000	1	1
gsk 1070916	Homo sapiens (human)	Kd	8.5000	1	1
jnj38877605	Homo sapiens (human)	Kd	30.0000	1	1
dinaciclib	Homo sapiens (human)	Kd	30.0000	1	1
gilteritinib	Homo sapiens (human)	Kd	30.0000	1	1
alectinib	Homo sapiens (human)	Kd	30.0000	1	1
glpg0634	Homo sapiens (human)	Kd	30.0000	1	1
encorafenib	Homo sapiens (human)	Kd	30.0000	1	1
bms-911543	Homo sapiens (human)	Kd	30.0000	1	2
gsk2141795	Homo sapiens (human)	Kd	30.0000	1	1
azd8186	Homo sapiens (human)	Kd	30.0000	1	1
byl719	Homo sapiens (human)	Kd	30.0000	1	1
cep-32496	Homo sapiens (human)	Kd	0.5660	1	1
rociletinib	Homo sapiens (human)	Kd	30.0000	1	1
ceritinib	Homo sapiens (human)	Kd	30.0000	1	1
azd1208	Homo sapiens (human)	Kd	30.0000	1	2
vx-509	Homo sapiens (human)	Kd	30.0000	1	1
debio 1347	Homo sapiens (human)	Kd	30.0000	1	1
volitinib	Homo sapiens (human)	Kd	30.0000	1	1
osimertinib	Homo sapiens (human)	Kd	30.0000	1	1
at 9283	Homo sapiens (human)	Kd	30.0000	1	1
otssp167	Homo sapiens (human)	Kd	30.0000	1	1
chir 258	Homo sapiens (human)	Kd	16.6667	3	3
osi 027	Homo sapiens (human)	Kd	30.0000	1	1
nintedanib	Homo sapiens (human)	Kd	20.0000	2	2
bay 80-6946	Homo sapiens (human)	Kd	30.0000	1	1
pp242	Homo sapiens (human)	Kd	10.0000	1	1

Enables

This protein enables 10 target(s):

Target	Category	Definition
protein serine/threonine kinase activity	molecular function	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]
MAP kinase activity	molecular function	Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. [GOC:ma, ISBN:0198547684]
MAP kinase kinase activity	molecular function	Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate. [ISBN:0198547684]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
protein phosphatase binding	molecular function	Binding to a protein phosphatase. [GOC:jl]
mitogen-activated protein kinase p38 binding	molecular function	Binding to mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation. [GOC:curators, PMID:17827184]
NFAT protein binding	molecular function	Binding to NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system. [PMID:15928679]
protein serine kinase activity	molecular function	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989]

Located In

This protein is located in 11 target(s):

Target	Category	Definition
spindle pole	cellular component	Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. [GOC:clt]
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
nuclear speck	cellular component	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. [http://www.cellnucleus.com/]
secretory granule lumen	cellular component	The volume enclosed by the membrane of a secretory granule. [GOC:rph]
glutamatergic synapse	cellular component	A synapse that uses glutamate as a neurotransmitter. [GOC:dos]
ficolin-1-rich granule lumen	cellular component	Any membrane-enclosed lumen that is part of a ficolin-1-rich granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620]

Active In

This protein is active in 3 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 64 target(s):

Target	Category	Definition
DNA damage checkpoint signaling	biological process	A signal transduction process that contributes to a DNA damage checkpoint. [GOC:mah]
cell morphogenesis	biological process	The developmental process in which the size or shape of a cell is generated and organized. [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
cartilage condensation	biological process	The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes. [ISBN:0878932437]
angiogenesis	biological process	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453]
osteoblast differentiation	biological process	The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone. [CL:0000062, GO_REF:0000034, GOC:jid]
placenta development	biological process	The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. [GOC:add, ISBN:068340007X]
response to dietary excess	biological process	The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure. [GOC:pg, GOC:pr, PMID:12161655]
chondrocyte differentiation	biological process	The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage. [GOC:dph]
negative regulation of inflammatory response to antigenic stimulus	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus. [GOC:add]
glucose metabolic process	biological process	The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. [ISBN:0198506732]
regulation of transcription by RNA polymerase II	biological process	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
transcription by RNA polymerase II	biological process	The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). [GOC:jl, GOC:txnOH, ISBN:0321000382]
apoptotic process	biological process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
chemotaxis	biological process	The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [ISBN:0198506732]
signal transduction	biological process	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
cell surface receptor signaling pathway	biological process	The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:signaling]
cell surface receptor protein serine/threonine kinase signaling pathway	biological process	The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]
skeletal muscle tissue development	biological process	The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers. [GOC:mtg_muscle]
positive regulation of gene expression	biological process	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
positive regulation of myotube differentiation	biological process	Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. [GOC:dph, GOC:tb]
peptidyl-serine phosphorylation	biological process	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. [RESID:AA0037]
fatty acid oxidation	biological process	The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen. [ISBN:0198506732, MetaCyc:FAO-PWY]
platelet activation	biological process	A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. [http://www.graylab.ac.uk/omd/]
regulation of ossification	biological process	Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. [GOC:go_curators]
osteoclast differentiation	biological process	The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. [CL:0000092, GOC:add, ISBN:0781735149, PMID:12161749]
stress-activated protein kinase signaling cascade	biological process	The series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays a signal. [GOC:mah]
positive regulation of cyclase activity	biological process	Any process that activates or increases the activity of a cyclase. [GOC:mah]
lipopolysaccharide-mediated signaling pathway	biological process	The series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. [GOC:mah, GOC:signaling, PMID:15379975]
response to muramyl dipeptide	biological process	Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan. [GOC:add]
positive regulation of interleukin-12 production	biological process	Any process that activates or increases the frequency, rate, or extent of interleukin-12 production. [GOC:mah]
response to insulin	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. [GOC:mah, ISBN:0198506732]
negative regulation of hippo signaling	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling. [GOC:bf]
intracellular signal transduction	biological process	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
cellular response to vascular endothelial growth factor stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus. [GOC:BHF, GOC:rl, PMID:18440775]
response to muscle stretch	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length. [GOC:BHF, GOC:vk, PMID:14583192]
p38MAPK cascade	biological process	A MAPK cascade containing at least the p38MAPK (MAPK14) MAP kinase, or Hog1 in yeast. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of p38MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The p38MAPK cascade is activated by stress signals, including hyperosmolarity, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation. [PMID:20811974, PMID:23125017, PMID:32794416]
positive regulation of protein import into nucleus	biological process	Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus. [GOC:jl]
signal transduction in response to DNA damage	biological process	A cascade of processes induced by the detection of DNA damage within a cell. [GOC:go_curators]
positive regulation of erythrocyte differentiation	biological process	Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation. [GOC:go_curators]
positive regulation of myoblast differentiation	biological process	Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:go_curators, GOC:mtg_muscle]
positive regulation of transcription by RNA polymerase II	biological process	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
glucose import	biological process	The directed movement of the hexose monosaccharide glucose into a cell or organelle. [GOC:ai]
positive regulation of glucose import	biological process	Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. [GOC:ai, GOC:dph, GOC:tb]
vascular endothelial growth factor receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb, GOC:signaling]
stem cell differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. [CL:0000034, GOC:isa_complete]
striated muscle cell differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. [CL:0000737, GOC:ai]
positive regulation of muscle cell differentiation	biological process	Any process that activates or increases the frequency, rate or extent of muscle cell differentiation. [CL:0000187, GOC:ai]
stress-activated MAPK cascade	biological process	A MAPK cascade that starts with the activation of a stress-activated MAP kinase cascade. [GOC:ai, PMID:15936270]
positive regulation of cardiac muscle cell proliferation	biological process	Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation. [GOC:dph, GOC:rph]
bone development	biological process	The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components. [GOC:dph]
3'-UTR-mediated mRNA stabilization	biological process	An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA. [GOC:mah, PMID:19029303]
cellular response to lipoteichoic acid	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor. [GOC:mah]
cellular response to tumor necrosis factor	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus. [GOC:mah]
cellular response to ionizing radiation	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. [GOC:mah]
cellular response to UV-B	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm. [GOC:mah]
negative regulation of canonical Wnt signaling pathway	biological process	Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:dph, GOC:tb]
positive regulation of brown fat cell differentiation	biological process	Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. [GOC:BHF]
cellular senescence	biological process	A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest. [GOC:BHF, PMID:28682291]
stress-induced premature senescence	biological process	A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays. [GOC:BHF]
cellular response to virus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. [GOC:dos]
regulation of synaptic membrane adhesion	biological process	Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes. [GOC:dos]
regulation of cytokine production involved in inflammatory response	biological process	Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response. [GOC:TermGenie]
positive regulation of myoblast fusion	biological process	Any process that activates or increases the frequency, rate or extent of myoblast fusion. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645]
positive regulation of reactive oxygen species metabolic process	biological process	Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process. [GOC:mah]