Cytosol aminopeptidase

A cytosol aminopeptidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P28838]

Synonyms

EC 3.4.11.1;
Cysteinylglycine-S-conjugate dipeptidase;
3.4.13.23;
Leucine aminopeptidase 3;
LAP-3;
Leucyl aminopeptidase;
Peptidase S;
Proline aminopeptidase;
3.4.11.5;
Prolyl aminopeptidase

Research

Bioassay Publications (8)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	3 (37.50)	18.7374
1990's	1 (12.50)	18.2507
2000's	2 (25.00)	29.6817
2010's	2 (25.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (10)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
isoamylamine	Homo sapiens (human)	Ki	50,000.0000	1	1
1-aminomethylphosphonic acid	Homo sapiens (human)	Ki	1,040.0000	1	1
ubenimex	Homo sapiens (human)	IC50	11.2000	1	1
ubenimex	Homo sapiens (human)	Ki	0.0103	2	2
1-(aminoethyl)phosphonic acid	Homo sapiens (human)	Ki	240.0000	1	1
1-amino-2-phenylethylphosphonic acid	Homo sapiens (human)	Ki	0.4200	1	1
jtp 4819	Homo sapiens (human)	IC50	100.0000	1	1
amastatin	Homo sapiens (human)	Ki	5.1125	4	4
leucine phosphonic acid	Homo sapiens (human)	Ki	0.2300	1	1
apstatin	Homo sapiens (human)	IC50	0.3000	1	1
ubenimex	Homo sapiens (human)	Ki	20.0000	1	1

Enables

This protein enables 7 target(s):

Target	Category	Definition
aminopeptidase activity	molecular function	Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837]
carboxypeptidase activity	molecular function	Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain. [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
metalloexopeptidase activity	molecular function	Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml]
manganese ion binding	molecular function	Binding to a manganese ion (Mn). [GOC:ai]
metalloaminopeptidase activity	molecular function	Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]
peptidase activity	molecular function	Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. [GOC:jl, ISBN:0815332181]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
trans-Golgi network	cellular component	The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. [GOC:vw, ISBN:0815316194]
focal adhesion	cellular component	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 1 target(s):

Target	Category	Definition
proteolysis	biological process	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]

chemdatabank.com