Compounds > hti-286
Page last updated: 2024-10-14

hti-286

Description

HTI-286: a synthetic analog of the tripeptide hemiasterlin; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6918637
CHEMBL ID182319
SCHEMBL ID57122
SCHEMBL ID4378011
MeSH IDM0460181

Synonyms (41)

Synonym
phenylhemiasterlin
(e)-(s)-4-{[(s)-3,3-dimethyl-2-((s)-3-methyl-2-methylamino-3-phenyl-butyrylamino)-butyryl]-methyl-amino}-2,5-dimethyl-hex-2-enoic acid
bdbm50150589
(s)-2,5-dimethyl-4-((s)-n,3,3-trimethyl-2-((s)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enoic acid
(s,e)-2,5-dimethyl-4-((s)-n,3,3-trimethyl-2-((s)-3-methyl-2-(methylamino)-3-phenylbutanamido)butanamido)hex-2-enoic acid
4-{[3,3-dimethyl-2-(3-methyl-2-methylamino-3-phenyl-butyrylamino)-butyryl]-methyl-amino}-2,5-dimethyl-hex-2-enoic acid
spa-110
taltobulin
hti-286
D06001
taltobulin (usan/inn)
228266-40-8
l-valinamide, n,beta,beta-trimethyl-l-phenylalanyl-n-((1s,2e)-3-carboxy-1-(1-methylethyl)-2-butenyl)-n,3-dimethyl-
l-valinamide, n,beta,beta-trimethyl-l-phenylalanine-n-((1s,2e)-3-carboxy-1-(1-methylethyl)-2-butenyl)-n,3-dimethyl-
(4s)-4-(((2s)-3,3-dimethyl-2-(((2s)-3-methyl-2-(methylamino)-3-phenylbutanoyl)amino)butanoyl)methylamino)-2,5-dimethylhex-2-enoic acid
hti 286
spa 110
n,beta,beta-trimethyl-l-phenylalanyl-n-[(3s,4e)-5-carboxy-2-methylhex-4-en-3-yl]-n,3-dimethyl-l-valinamide
CHEMBL182319 ,
(e,4s)-4-[[(2s)-3,3-dimethyl-2-[[(2s)-3-methyl-2-(methylamino)-3-phenylbutanoyl]amino]butanoyl]-methylamino]-2,5-dimethylhex-2-enoic acid
unii-j6d6912bxs
taltobulin [usan:inn]
j6d6912bxs ,
(4s)-4-[[(2s)-3,3-dimethyl-2-[[(2s)-3-methyl-2-(methylamino)-3-phenylbutanoyl]amino]butanoyl]methylamino]-2,5-dimethylhex-2-enoic acid
taltobulin [inn]
taltobulin [usan]
l-valinamide,n,.beta.,.beta.-trimethyl-l-phenylalanine-n-((1s,2e)-3-carboxy-1-(1-methylethyl)-2-butenyl)-n,3-dimethyl
CS-3299
HY-15584
SCHEMBL57122
SCHEMBL4378011
CNTMOLDWXSVYKD-PSRNMDMQSA-N
n,beta,beta-trimethyl-l-phenylalanyl-n1-[(1s,2e)-3-carboxy-1-isopropylbut-2-enyl]-n1,3-dimethyl-l-valinamide
DTXSID2041040
NCGC00386600-02
hti-286;spa-110
Q27281267
A911116
(s,e)-4-(((s)-3,3-dimethyl-1-((s)-3-methyl-2-(methylamino)-3-phenylbutanamido)-1-oxobutan-2-yl)(methyl)amino)-2,5-dimethylhex-2-enoic acid
MS-28787
E98768

Bioavailability

ExcerptReference
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency33.78580.01237.983543.2770AID1645841
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Tubulin beta-1 chainHomo sapiens (human)Kd0.26000.05800.58941.8600AID238035
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (8)

Processvia Protein(s)Taxonomy
platelet formationTubulin beta-1 chainHomo sapiens (human)
thyroid gland developmentTubulin beta-1 chainHomo sapiens (human)
microtubule polymerizationTubulin beta-1 chainHomo sapiens (human)
spindle assemblyTubulin beta-1 chainHomo sapiens (human)
thyroid hormone transportTubulin beta-1 chainHomo sapiens (human)
platelet aggregationTubulin beta-1 chainHomo sapiens (human)
mitotic cell cycleTubulin beta-1 chainHomo sapiens (human)
microtubule cytoskeleton organizationTubulin beta-1 chainHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (4)

Processvia Protein(s)Taxonomy
GTPase activityTubulin beta-1 chainHomo sapiens (human)
metal ion bindingTubulin beta-1 chainHomo sapiens (human)
structural constituent of cytoskeletonTubulin beta-1 chainHomo sapiens (human)
GTP bindingTubulin beta-1 chainHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (6)

Processvia Protein(s)Taxonomy
cytoplasmTubulin beta-1 chainHomo sapiens (human)
microtubule cytoskeletonTubulin beta-1 chainHomo sapiens (human)
intercellular bridgeTubulin beta-1 chainHomo sapiens (human)
extracellular exosomeTubulin beta-1 chainHomo sapiens (human)
mitotic spindleTubulin beta-1 chainHomo sapiens (human)
microtubuleTubulin beta-1 chainHomo sapiens (human)
cytoplasmTubulin beta-1 chainHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (43)

Assay IDTitleYearJournalArticle
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347160Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347159Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID245713Minimum tolerated dose against Lox melanoma human xenograft models in athymic mice2004Bioorganic & medicinal chemistry letters, Nov-01, Volume: 14, Issue:21
Synthesis and activity of novel analogs of hemiasterlin as inhibitors of tubulin polymerization: modification of the A segment.
AID247845Inhibitory concentration against Lox melanoma cells2004Journal of medicinal chemistry, Sep-09, Volume: 47, Issue:19
Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286).
AID247728Inhibitory concentration against HCT-15 cells was evaluated2004Journal of medicinal chemistry, Sep-09, Volume: 47, Issue:19
Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286).
AID252005Percent inhibition of bovine microtubule-assisted protein (MAP) rich tubulin polymerisation at concentration of 0.3 uM2004Bioorganic & medicinal chemistry letters, Nov-01, Volume: 14, Issue:21
Synthesis and activity of novel analogs of hemiasterlin as inhibitors of tubulin polymerization: modification of the A segment.
AID248618Compound was tested for the cytotoxicity against KB-8-5 cell line expressing P-glycoprotein; value ranges from 1.2-5 nM2004Bioorganic & medicinal chemistry letters, Aug-16, Volume: 14, Issue:16
Tubulin inhibitors. Synthesis and biological activity of HTI-286 analogs with B-segment heterosubstituents.
AID247858Concentration required to inhibit tumor cell growth in KB-3-1 cells2004Journal of medicinal chemistry, Sep-09, Volume: 47, Issue:19
Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286).
AID248889Concentration required to kill human epidermoid KBV1 cell lines containing very high levels of P-glycoprotein after 3 days of continuous exposure2004Bioorganic & medicinal chemistry letters, Nov-01, Volume: 14, Issue:21
Synthesis and activity of novel analogs of hemiasterlin as inhibitors of tubulin polymerization: modification of the A segment.
AID244785Minimum effective dose was evaluated in lox melanoma human tumor graft model in athymic mice when administered intravenously2004Journal of medicinal chemistry, Sep-09, Volume: 47, Issue:19
Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286).
AID331685Antiproliferative activity against human 1A9 cells2008Bioorganic & medicinal chemistry letters, May-01, Volume: 18, Issue:9
Tubulysin analogs incorporating desmethyl and dimethyl tubuphenylalanine derivatives.
AID249650Effect at 1.6 mpk against DLD1 cell line expressing P-glycoprotein transporter in athymic mice; Active2004Bioorganic & medicinal chemistry letters, Nov-01, Volume: 14, Issue:21
Synthesis and activity of novel analogs of hemiasterlin as inhibitors of tubulin polymerization: modification of the A segment.
AID331686Inhibition of rat brain tubulin polymerization2008Bioorganic & medicinal chemistry letters, May-01, Volume: 18, Issue:9
Tubulysin analogs incorporating desmethyl and dimethyl tubuphenylalanine derivatives.
AID411786Antiproliferative activity against human MCF7 cells after 4 days by SRB assay2009Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
Total synthesis and biological evaluation of tubulysin U, tubulysin V, and their analogues.
AID251729Compound was evaluated for the inhibition of MAP-rich tubulin polymerisation at 0.3 uM2004Bioorganic & medicinal chemistry letters, Aug-16, Volume: 14, Issue:16
Tubulin inhibitors. Synthesis and biological activity of HTI-286 analogs with B-segment heterosubstituents.
AID247685Inhibitory concentration against KM20 cells was evaluated2004Journal of medicinal chemistry, Sep-09, Volume: 47, Issue:19
Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286).
AID248620Compound was tested for the cytotoxicity against KB-V1 cell line expressing P-glycoprotein; value ranges from 40-140 nM2004Bioorganic & medicinal chemistry letters, Aug-16, Volume: 14, Issue:16
Tubulin inhibitors. Synthesis and biological activity of HTI-286 analogs with B-segment heterosubstituents.
AID411785Antiproliferative activity against human 1A9 cells after 4 days by SRB assay2009Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
Total synthesis and biological evaluation of tubulysin U, tubulysin V, and their analogues.
AID251767Compound was evaluated for the ability to inhibit cell-free tubulin polymerisation at 0.5 uM2004Bioorganic & medicinal chemistry letters, Aug-16, Volume: 14, Issue:16
D-piece modifications of the hemiasterlin analog HTI-286 produce potent tubulin inhibitors.
AID245717Minimum tolerated dose was evaluated in lox melanoma human tumor graft model in athymic mice when administered intravenously2004Journal of medicinal chemistry, Sep-09, Volume: 47, Issue:19
Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286).
AID248401Compound was tested for cytotoxicity against paclitaxel resistant KB-8-5 cell line expressing P-glycoprotein2004Bioorganic & medicinal chemistry letters, Aug-16, Volume: 14, Issue:16
D-piece modifications of the hemiasterlin analog HTI-286 produce potent tubulin inhibitors.
AID247787Inhibitory concentration against NCI-H1299 cells was evaluated2004Journal of medicinal chemistry, Sep-09, Volume: 47, Issue:19
Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286).
AID249651Effect at 1.6 mpk against MX1W cell line expressing P-glycoprotein transporter in athymic mice; Active2004Bioorganic & medicinal chemistry letters, Nov-01, Volume: 14, Issue:21
Synthesis and activity of novel analogs of hemiasterlin as inhibitors of tubulin polymerization: modification of the A segment.
AID247640Inhibitory concentration against S1 cells was evaluated2004Journal of medicinal chemistry, Sep-09, Volume: 47, Issue:19
Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286).
AID326224Cytotoxicity against human 1A9 cells2008Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
Cytotoxic simplified tubulysin analogues.
AID354406Cytotoxicity activity against human MCF7 cells expressing p53 mutant by MTT assay2003Journal of natural products, Feb, Volume: 66, Issue:2
Synthesis and antimitotic/cytotoxic activity of hemiasterlin analogues.
AID326225Inhibition of rat brain tubulin polymerization2008Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
Cytotoxic simplified tubulysin analogues.
AID248081Compound was tested for the cytotoxicity against KB-3-1 cell line; value ranges from 0.6-2 nM2004Bioorganic & medicinal chemistry letters, Aug-16, Volume: 14, Issue:16
Tubulin inhibitors. Synthesis and biological activity of HTI-286 analogs with B-segment heterosubstituents.
AID411787Inhibition of tubulin polymerization2009Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
Total synthesis and biological evaluation of tubulysin U, tubulysin V, and their analogues.
AID248380Compound was tested for cytotoxicity against paclitaxel resistant KB-V1 cell line expressing P-glycoprotein2004Bioorganic & medicinal chemistry letters, Aug-16, Volume: 14, Issue:16
D-piece modifications of the hemiasterlin analog HTI-286 produce potent tubulin inhibitors.
AID354405Antimitotic activity against human MCF7 cells expressing p53 mutant by MTT assay2003Journal of natural products, Feb, Volume: 66, Issue:2
Synthesis and antimitotic/cytotoxic activity of hemiasterlin analogues.
AID247853Compound was tested for cytotoxicity against paclitaxel sensitive KB-3-1 cell line2004Bioorganic & medicinal chemistry letters, Aug-16, Volume: 14, Issue:16
D-piece modifications of the hemiasterlin analog HTI-286 produce potent tubulin inhibitors.
AID251815Percent inhibition of tubulin polymerization at 0.3 uM concentration2004Journal of medicinal chemistry, Sep-09, Volume: 47, Issue:19
Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286).
AID244780Minimum effective dose against Lox melanoma human xenograft models in athymic mice2004Bioorganic & medicinal chemistry letters, Nov-01, Volume: 14, Issue:21
Synthesis and activity of novel analogs of hemiasterlin as inhibitors of tubulin polymerization: modification of the A segment.
AID247859Concentration required to inhibit tumor cell growth in KB-8-5 cells2004Journal of medicinal chemistry, Sep-09, Volume: 47, Issue:19
Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286).
AID248904Concentration required to kill human epidermoid KB-3-1 cell lines containing very low levels of P-glycoprotein after 3 days of continuous exposure2004Bioorganic & medicinal chemistry letters, Nov-01, Volume: 14, Issue:21
Synthesis and activity of novel analogs of hemiasterlin as inhibitors of tubulin polymerization: modification of the A segment.
AID249654Effect at 1.6 mpk against HCT-15 cell line expressing P-glycoprotein transporter in athymic mice; Active2004Bioorganic & medicinal chemistry letters, Nov-01, Volume: 14, Issue:21
Synthesis and activity of novel analogs of hemiasterlin as inhibitors of tubulin polymerization: modification of the A segment.
AID248874Concentration required to kill human epidermoid KB85 cell lines containing moderate levels of P-glycoprotein after 3 days of continuous exposure2004Bioorganic & medicinal chemistry letters, Nov-01, Volume: 14, Issue:21
Synthesis and activity of novel analogs of hemiasterlin as inhibitors of tubulin polymerization: modification of the A segment.
AID247837Concentration required to inhibit tumor cell growth in KB-V1 cells2004Journal of medicinal chemistry, Sep-09, Volume: 47, Issue:19
Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286).
AID238035Binding affinity towards tubulin2004Journal of medicinal chemistry, Sep-09, Volume: 47, Issue:19
Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (27)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's20 (74.07)29.6817
2010's5 (18.52)24.3611
2020's2 (7.41)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (7.41%)5.53%
Reviews1 (3.70%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other24 (88.89%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
glycerol
Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.		3.5620alditol;
triol		algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent
pyruvic acid
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed). pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.		2.02102-oxo monocarboxylic acidcofactor;
fundamental metabolite
mitoxantrone
Mitoxantrone: An anthracenedione-derived antineoplastic agent.. mitoxantrone : A dihydroxyanthraquinone that is 1,4-dihydroxy-9,10-anthraquinone which is substituted by 6-hydroxy-1,4-diazahexyl groups at positions 5 and 8.		2.0210dihydroxyanthraquinoneanalgesic;
antineoplastic agent
mitomycin
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.		3.4311mitomycinalkylating agent;
antineoplastic agent
alanine
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.		2.0210alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
tyrosine
Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.		2.0210amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
phenylalanine
Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.		2.0410amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid		algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
methylamine
methyl group : An alkyl group that is the univalent group derived from methane by removal of a hydrogen atom.		2.0210methylamines;
one-carbon compound;
primary aliphatic amine		mouse metabolite
cyclohexanol
Cyclohexanols: Monohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers.. cyclohexanols : An alcohol in which one or more hydroxy groups are attached to a cyclohexane skeleton.		3.2510cyclohexanols;
secondary alcohol		solvent
thiazoles
[no description available]		2.05101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
podophyllotoxin
Podophyllum: A genus of poisonous American herbs, family BERBERIDACEAE. The roots yield PODOPHYLLOTOXIN and other pharmacologically important agents. The plant was formerly used as a cholagogue and cathartic. It is different from the European mandrake, MANDRAGORA.		2.0410furonaphthodioxole;
lignan;
organic heterotetracyclic compound		antimitotic;
antineoplastic agent;
keratolytic drug;
microtubule-destabilising agent;
plant metabolite;
tubulin modulator
paraquat
Paraquat: A poisonous dipyridilium compound used as contact herbicide. Contact with concentrated solutions causes irritation of the skin, cracking and shedding of the nails, and delayed healing of cuts and wounds.. paraquat : An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.		2.0510organic cationgeroprotector;
herbicide
sodium azide
Sodium Azide: A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed). sodium azide : The sodium salt of hydrogen azide (hydrazoic acid).		2.0210inorganic sodium saltantibacterial agent;
explosive;
mitochondrial respiratory-chain inhibitor;
mutagen
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.9340taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
docetaxel anhydrous
Docetaxel: A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER.. docetaxel anhydrous : A tetracyclic diterpenoid that is paclitaxel with the N-benzyloxycarbonyl group replaced by N-tert-butoxycarbonyl, and the acetoxy group at position 10 replaced by a hydroxy group.		3.4311secondary alpha-hydroxy ketone;
tetracyclic diterpenoid		antimalarial;
antineoplastic agent;
photosensitizing agent
stilbenes
Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.		2.4320stilbene
fosbretabulin
[no description available]		2.4420stilbenoid
fosbretabulin
fosbretabulin: a microtubule destabilizing agent isolated from Combretum caffrum; structure in first source		2.0410
hemiasterlin a
hemiasterlin A: potent cytotoxic peptide from marine sponge, Hemiasterella minor; structure given in first source		2.4220
hemiasterlin
hemiasterlin: structure in first source		5.68102
myxothiazol
myxothiazol: strobilurin analogue; methoxyacrylamide derivative; antifungal antibiotic from Myxococcus fulvus; structure given in first source. myxothiazol : A 2,4'-bi-1,3-thiazole substituted at the 4-position with a (1E,3S,4R,5E)-7-amino-3,5-dimethoxy-4-methyl-7-oxohepta-1,5-dien-1-yl] group and at the 2'-position with a (2S,3E,5E)-7-methylocta-3,5-dien-2-yl group. It is an inhibitor of coenzyme Q - cytochrome c reductase.		2.0510
dolastatin 10
dolastatin 10: from mollusk Dolabella auricularia; contains four amino acids, dolavaline, dolaisoleucine, dolaproine, valine and the primary amine dolaphenine; deo-dolastatin 10 is a new dolastatin 10 chiral derivative with MW of 784. dolastatin 10 : A tetrapeptide that is isolated from the sea hare Dolabella auricularia. It is a potent anticancer agent which inhibits tubulin polymerization.		2.42201,3-thiazoles;
tetrapeptide		animal metabolite;
antineoplastic agent;
apoptosis inducer;
marine metabolite;
microtubule-destabilising agent
tubulysin a
tubulysin A: has both antiangiogenic and antineoplastic activities; structure in first source		2.0410carboxylic acid;
diester
tubulysin d
tubulysin D: structure in first source		2.4520carboxylic acid;
diester
tubulysin u
tubulysin U: structure in first source		2.0510
tubulysin v
tubulysin V: structure in first source		2.0510
guanosine triphosphate
Guanosine Triphosphate: Guanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety.		2.0210guanosine 5'-phosphate;
purine ribonucleoside 5'-triphosphate		Escherichia coli metabolite;
mouse metabolite;
uncoupling protein inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Malignant Melanoma
[description not available]		02.0210
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		02.0210
Benign Neoplasms
[description not available]		03.3420
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.3420
B16 Melanoma
[description not available]		02.0210
Cancer of Ovary
[description not available]		02.4320
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		02.4320
Congenital Zika Syndrome
[description not available]		02.2510
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.2510
Zika Virus Infection
A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.		02.2510
Bladder Cancer
[description not available]		03.8321
Urinary Bladder Neoplasms
Tumors or cancer of the URINARY BLADDER.		03.8321
Experimental Neoplasms
[description not available]		02.9310
Angiogenesis, Pathologic
[description not available]		02.9310
Necrosis
The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.		02.9310
Hepatocellular Carcinoma
[description not available]		02.0310
Cancer of Liver
[description not available]		02.0310
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		02.0310
Liver Neoplasms
Tumors or cancer of the LIVER.		02.0310
Cancer of Prostate
[description not available]		03.4311
Hormone-Dependent Neoplasms
[description not available]		03.4311
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		03.4311