Page last updated: 2024-08-02 15:34:55
alpha-synuclein
Description
alpha-Synuclein: A synuclein that is a major component of LEWY BODIES and plays a role in SYNUCLEINOPATHIES, neurodegeneration and neuroprotection. [MeSH]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 10307709 |
| MeSH ID | M0159750 |
Synonyms (5)
| Synonym |
|---|
| alpha-synuclein |
| EX-A7463 |
| 440645-08-9 |
| AKOS040758135 |
| ??-synuclein (61-75) |
Research
Studies (10,687)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 122 (1.14) | 18.2507 |
| 2000's | 2177 (20.37) | 29.6817 |
| 2010's | 5350 (50.06) | 24.3611 |
| 2020's | 3038 (28.43) | 2.80 |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 29 (0.27%) | 5.53% |
| Reviews | 1,902 (17.58%) | 6.00% |
| Case Studies | 189 (1.75%) | 4.05% |
| Observational | 13 (0.12%) | 0.25% |
| Other | 8,688 (80.29%) | 84.16% |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|
| acetylcarnitine | | O-acylcarnitine | human metabolite | 2010 | 2014 | 12.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| protocatechuic acid | | catechols;
dihydroxybenzoic acid | antineoplastic agent;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor;
human xenobiotic metabolite;
plant metabolite | 2009 | 2019 | 10.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| 3-hydroxykynurenine | | hydroxykynurenine | human metabolite | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| phosphoserine | | non-proteinogenic alpha-amino acid;
O-phosphoamino acid;
serine derivative | human metabolite | 2004 | 2021 | 10.1 | low | 0 | 0 | 0 | 6 | 10 | 2 |
| gamma-aminobutyric acid | | amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid | human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule | 2003 | 2022 | 12.0 | low | 0 | 0 | 0 | 5 | 4 | 1 |
| 5-hydroxytryptophan | | hydroxytryptophan | human metabolite;
neurotransmitter | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| acetone | | ketone body;
methyl ketone;
propanones;
volatile organic compound | EC 3.5.1.4 (amidase) inhibitor;
human metabolite;
polar aprotic solvent | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| adenine | | 6-aminopurines;
purine nucleobase | Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2001 | 2018 | 11.9 | low | 0 | 0 | 0 | 2 | 8 | 0 |
| ammonium hydroxide | | azane;
gas molecular entity;
mononuclear parent hydride | EC 3.5.1.4 (amidase) inhibitor;
metabolite;
mouse metabolite;
neurotoxin;
NMR chemical shift reference compound;
nucleophilic reagent;
refrigerant | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| quinacrine | | acridines;
aromatic ether;
organochlorine compound;
tertiary amino compound | antimalarial;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| beta-alanine | | amino acid zwitterion;
beta-amino acid | agonist;
fundamental metabolite;
human metabolite;
inhibitor;
neurotransmitter | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| betaine | | amino-acid betaine;
glycine derivative | fundamental metabolite | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| bromide | | halide anion;
monoatomic bromine | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| butyric acid | | fatty acid 4:0;
straight-chain saturated fatty acid | human urinary metabolite;
Mycoplasma genitalium metabolite | 2017 | 2021 | 4.7 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| carbamates | | amino-acid anion | | 2015 | 2020 | 6.7 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| formic acid | | monocarboxylic acid | antibacterial agent;
astringent;
metabolite;
protic solvent;
solvent | 1998 | 2021 | 15.4 | low | 0 | 0 | 1 | 2 | 1 | 1 |
| catechol | | catechols | allelochemical;
genotoxin;
plant metabolite | 2006 | 2021 | 11.2 | low | 0 | 0 | 0 | 2 | 1 | 1 |
| methane | | alkane;
gas molecular entity;
mononuclear parent hydride;
one-carbon compound | bacterial metabolite;
fossil fuel;
greenhouse gas | 2019 | 2023 | 3.4 | low | 0 | 0 | 0 | 0 | 3 | 4 |
| choline | | cholines | allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter;
nutrient;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| chlorine | | halide anion;
monoatomic chlorine | cofactor;
Escherichia coli metabolite;
human metabolite | 1999 | 2019 | 16.1 | low | 0 | 0 | 2 | 5 | 5 | 0 |
| coumarin | | coumarins | fluorescent dye;
human metabolite;
plant metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| cuminaldehyde | | benzaldehydes | insecticide;
plant metabolite;
volatile oil component | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| gallic acid | | trihydroxybenzoic acid | antineoplastic agent;
antioxidant;
apoptosis inducer;
astringent;
cyclooxygenase 2 inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
geroprotector;
human xenobiotic metabolite;
plant metabolite | 2014 | 2020 | 7.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| hydrogen sulfide | | gas molecular entity;
hydracid;
mononuclear parent hydride;
sulfur hydride | Escherichia coli metabolite;
genotoxin;
metabolite;
signalling molecule;
toxin;
vasodilator agent | 2019 | 2022 | 3.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| nornicotine | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3-hydroxybutyric acid | | (omega-1)-hydroxy fatty acid;
3-hydroxy monocarboxylic acid;
hydroxybutyric acid | human metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| guaiacol | | guaiacols | disinfectant;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
expectorant;
plant metabolite | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 3,4-dihydroxyphenylacetic acid | | catechols;
dihydroxyphenylacetic acid | human metabolite | 2001 | 2022 | 11.3 | low | 1 | 0 | 0 | 16 | 23 | 3 |
| creatine | | glycine derivative;
guanidines;
zwitterion | geroprotector;
human metabolite;
mouse metabolite;
neuroprotective agent;
nutraceutical | 2009 | 2016 | 11.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| cytosine | | aminopyrimidine;
pyrimidine nucleobase;
pyrimidone | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2001 | 2015 | 16.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| lactic acid | | 2-hydroxy monocarboxylic acid | algal metabolite;
Daphnia magna metabolite | 2004 | 2015 | 14.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| dimethyl sulfoxide | | sulfoxide;
volatile organic compound | alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger | 2001 | 2023 | 14.5 | low | 0 | 0 | 0 | 5 | 1 | 2 |
| formaldehyde | | aldehyde;
one-carbon compound | allergen;
carcinogenic agent;
disinfectant;
EC 3.5.1.4 (amidase) inhibitor;
environmental contaminant;
Escherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2008 | 2023 | 6.8 | low | 0 | 0 | 0 | 1 | 5 | 3 |
| glycine | | alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid | EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical | 2003 | 2023 | 13.1 | low | 0 | 0 | 0 | 10 | 8 | 1 |
| glycerol | | alditol;
triol | algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent | 2007 | 2022 | 8.3 | low | 0 | 0 | 0 | 1 | 4 | 1 |
| hydrogen carbonate | | carbon oxoanion | cofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2004 | 2006 | 19.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| histamine | | aralkylamino compound;
imidazoles | human metabolite;
mouse metabolite;
neurotransmitter | 2011 | 2023 | 7.2 | low | 0 | 0 | 0 | 0 | 3 | 1 |
| homogentisic acid | | dihydroxyphenylacetic acid;
hydroquinones | human metabolite;
plant metabolite | 2009 | 2017 | 11.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| hydrogen | | elemental hydrogen;
elemental molecule;
gas molecular entity | antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite | 2013 | 2022 | 7.4 | low | 0 | 0 | 0 | 0 | 11 | 1 |
| hydroquinone | | benzenediol;
hydroquinones | antioxidant;
carcinogenic agent;
cofactor;
Escherichia coli metabolite;
human xenobiotic metabolite;
mouse metabolite;
skin lightening agent | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| imidazole | | imidazole | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dihydroxyphenylalanine | | hydroxyphenylalanine;
non-proteinogenic alpha-amino acid;
tyrosine derivative | human metabolite | 2004 | 2023 | 13.0 | low | 0 | 0 | 0 | 7 | 3 | 2 |
| kynurenine | | aromatic ketone;
non-proteinogenic alpha-amino acid;
substituted aniline | human metabolite | 2013 | 2022 | 6.8 | low | 0 | 0 | 0 | 0 | 3 | 1 |
| thioctic acid | | dithiolanes;
heterocyclic fatty acid;
thia fatty acid | fundamental metabolite;
geroprotector | 2010 | 2018 | 10.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| malonic acid | | alpha,omega-dicarboxylic acid | human metabolite | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| racemethionine | | alpha-amino acid;
amino acid zwitterion;
sulfur-containing amino acid | algal metabolite;
Daphnia magna metabolite;
Escherichia coli metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| pyruvaldehyde | | 2-oxo aldehyde;
propanals | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2009 | 2022 | 7.1 | low | 0 | 0 | 0 | 1 | 6 | 1 |
| methanol | | alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound | amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite | 2004 | 2023 | 8.0 | low | 0 | 0 | 0 | 1 | 4 | 4 |
| phytic acid | | inositol phosphate | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| inositol | | cyclitol;
hexol | | 2005 | 2021 | 10.5 | low | 0 | 0 | 0 | 3 | 10 | 1 |
| melatonin | | acetamides;
tryptamines | anticonvulsant;
central nervous system depressant;
geroprotector;
hormone;
human metabolite;
immunological adjuvant;
mouse metabolite;
radical scavenger | 2007 | 2021 | 10.1 | low | 0 | 0 | 0 | 4 | 13 | 2 |
| nickel | | metal allergen;
nickel group element atom | epitope;
micronutrient | 2018 | 2022 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| niacinamide | | pyridine alkaloid;
pyridinecarboxamide;
vitamin B3 | anti-inflammatory agent;
antioxidant;
cofactor;
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
Escherichia coli metabolite;
geroprotector;
human urinary metabolite;
metabolite;
mouse metabolite;
neuroprotective agent;
Saccharomyces cerevisiae metabolite;
Sir2 inhibitor | 2008 | 2021 | 9.5 | low | 0 | 0 | 0 | 1 | 2 | 1 |
| nitrates | | monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species | | 2000 | 2023 | 16.0 | low | 0 | 0 | 2 | 19 | 3 | 4 |
| nitroxyl | | nitrogen oxoacid | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| nitrites | | monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species | human metabolite | 2003 | 2022 | 13.1 | low | 0 | 0 | 0 | 3 | 3 | 1 |
| hydroxide ion | | oxygen hydride | mouse metabolite | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| palmitic acid | | long-chain fatty acid;
straight-chain saturated fatty acid | algal metabolite;
Daphnia magna metabolite;
EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor;
plant metabolite | 2005 | 2022 | 13.3 | low | 0 | 0 | 0 | 2 | 0 | 1 |
| phosphorylcholine | | phosphocholines | allergen;
epitope;
hapten;
human metabolite;
mouse metabolite | 2006 | 2022 | 10.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| porphobilinogen | | aralkylamino compound;
dicarboxylic acid;
pyrroles | Escherichia coli metabolite;
metabolite;
mouse metabolite | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pqq cofactor | | orthoquinones;
pyrroloquinoline cofactor;
tricarboxylic acid | anti-inflammatory agent;
antioxidant;
cofactor;
water-soluble vitamin (role) | 2006 | 2022 | 7.2 | low | 0 | 0 | 0 | 1 | 1 | 2 |
| 1-propanol | | propan-1-ols;
short-chain primary fatty alcohol | metabolite;
protic solvent | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| pteridines | | azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
pteridines | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| putrescine | | alkane-alpha,omega-diamine | antioxidant;
fundamental metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pyrazole | | pyrazole | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pyridine | | azaarene;
mancude organic heteromonocyclic parent;
monocyclic heteroarene;
pyridines | environmental contaminant;
NMR chemical shift reference compound | 2007 | 2022 | 8.7 | low | 0 | 0 | 0 | 1 | 1 | 1 |
| pyridoxal phosphate | | methylpyridines;
monohydroxypyridine;
pyridinecarbaldehyde;
vitamin B6 phosphate | coenzyme;
cofactor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pyruvic acid | | 2-oxo monocarboxylic acid | cofactor;
fundamental metabolite | 2004 | 2022 | 10.0 | low | 0 | 0 | 0 | 1 | 1 | 1 |
| quinolinic acid | | pyridinedicarboxylic acid | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
NMDA receptor agonist | 1999 | 2018 | 13.3 | low | 0 | 0 | 1 | 0 | 2 | 0 |
| dithionite | | sulfur oxide;
sulfur oxoanion | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sarcosine | | N-alkylglycine zwitterion;
N-alkylglycine;
N-methyl-amino acid;
N-methylglycines | Escherichia coli metabolite;
glycine receptor agonist;
glycine transporter 1 inhibitor;
human metabolite;
mouse metabolite | 2001 | 2018 | 14.8 | low | 0 | 0 | 0 | 4 | 2 | 0 |
| spermidine | | polyazaalkane;
triamine | autophagy inducer;
fundamental metabolite;
geroprotector | 2003 | 2018 | 11.6 | low | 0 | 0 | 0 | 1 | 4 | 0 |
| spermine | | polyazaalkane;
tetramine | antioxidant;
fundamental metabolite;
immunosuppressive agent | 2003 | 2022 | 9.7 | low | 0 | 0 | 0 | 4 | 3 | 2 |
| taurine | | amino sulfonic acid;
zwitterion | antioxidant;
Escherichia coli metabolite;
glycine receptor agonist;
human metabolite;
mouse metabolite;
nutrient;
radical scavenger;
Saccharomyces cerevisiae metabolite | 2007 | 2018 | 11.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| thymine | | pyrimidine nucleobase;
pyrimidone | Escherichia coli metabolite;
human metabolite;
mouse metabolite | 2001 | 2015 | 16.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| trimethyloxamine | | tertiary amine oxide | Escherichia coli metabolite;
metabolite;
osmolyte | 2001 | 2019 | 14.4 | low | 0 | 0 | 0 | 3 | 2 | 0 |
| uric acid | | uric acid | Escherichia coli metabolite;
human metabolite;
mouse metabolite | 2010 | 2020 | 9.0 | low | 1 | 0 | 0 | 2 | 4 | 0 |
| urea | | isourea;
monocarboxylic acid amide;
one-carbon compound | Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2006 | 2022 | 8.9 | low | 0 | 0 | 0 | 3 | 8 | 4 |
| 2-amino-5-phosphonovalerate | | non-proteinogenic alpha-amino acid | NMDA receptor antagonist | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 7-hydroxy-2-n,n-dipropylaminotetralin | | tetralins | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sk&f-38393 | | benzazepine;
catechols;
secondary amino compound | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1-anilino-8-naphthalenesulfonate | | aminonaphthalene;
naphthalenesulfonic acid | fluorescent probe | 2001 | 2015 | 15.7 | low | 0 | 0 | 0 | 4 | 3 | 0 |
| 1-anilino-8-naphthalenesulfonate | | aminonaphthalene;
naphthalenesulfonic acid | fluorescent probe | 2001 | 2012 | 19.0 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | | methylpyridines;
phenylpyridine;
tetrahydropyridine | neurotoxin | 2000 | 2024 | 9.7 | low | 0 | 0 | 2 | 34 | 58 | 28 |
| n-(3-(aminomethyl)benzyl)acetamidine | | aralkylamine;
carboxamidine;
primary amino compound | angiogenesis inhibitor;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
geroprotector | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2,4-dinitrophenol | | dinitrophenol | allergen;
antiseptic drug;
bacterial xenobiotic metabolite;
geroprotector;
oxidative phosphorylation inhibitor | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| n-methyl-3,4-methylenedioxyamphetamine | | amphetamines;
benzodioxoles | neurotoxin | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3-aminobenzamide | | benzamides;
substituted aniline | EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| 3-hydroxybenzylhydrazine | | phenols | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3-methoxytyramine | | monomethoxybenzene;
phenols;
phenylethylamine;
primary amino compound | biomarker;
human blood serum metabolite;
human urinary metabolite | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 3-nitropropionic acid | | C-nitro compound | antimycobacterial drug;
EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor;
mycotoxin;
neurotoxin | 2005 | 2015 | 14.1 | low | 0 | 0 | 0 | 6 | 4 | 0 |
| 4-aminopyridine | | aminopyridine;
aromatic amine | avicide;
orphan drug;
potassium channel blocker | 2004 | 2017 | 13.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| homovanillic acid | | guaiacols;
monocarboxylic acid | human metabolite;
mouse metabolite | 2001 | 2019 | 14.1 | low | 1 | 0 | 0 | 8 | 6 | 0 |
| 5,5-dimethyl-1-pyrroline-1-oxide | | 1-pyrroline nitrones | neuroprotective agent;
spin trapping reagent | 2009 | 2016 | 11.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| phenytoin | | imidazolidine-2,4-dione | anticonvulsant;
drug allergen;
sodium channel blocker;
teratogenic agent | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| hydroxyindoleacetic acid | | indole-3-acetic acids | drug metabolite;
human metabolite;
mouse metabolite | 2010 | 2015 | 11.0 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| 8-cyclopentyl-1,3-dimethylxanthine | | oxopurine | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| oxyquinoline | | monohydroxyquinoline | antibacterial agent;
antifungal agrochemical;
antiseptic drug;
iron chelator | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| acetaminophen | | acetamides;
phenols | antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
cyclooxygenase 3 inhibitor;
environmental contaminant;
ferroptosis inducer;
geroprotector;
hepatotoxic agent;
human blood serum metabolite;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic | 2008 | 2021 | 9.5 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| adrenic acid | | docosatetraenoic acid | mouse metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| albuterol | | phenols;
phenylethanolamines;
secondary amino compound | beta-adrenergic agonist;
bronchodilator agent;
environmental contaminant;
xenobiotic | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| am 251 | | amidopiperidine;
carbohydrazide;
dichlorobenzene;
organoiodine compound;
pyrazoles | antidepressant;
antineoplastic agent;
apoptosis inducer;
CB1 receptor antagonist | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| ambroxol | | aromatic amine | | 2014 | 2022 | 6.8 | low | 0 | 0 | 0 | 0 | 3 | 1 |
| theophylline | | dimethylxanthine | adenosine receptor antagonist;
anti-asthmatic drug;
anti-inflammatory agent;
bronchodilator agent;
drug metabolite;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
fungal metabolite;
human blood serum metabolite;
immunomodulator;
muscle relaxant;
vasodilator agent | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| amitriptyline | | carbotricyclic compound;
tertiary amine | adrenergic uptake inhibitor;
antidepressant;
environmental contaminant;
tropomyosin-related kinase B receptor agonist;
xenobiotic | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| acetovanillone | | acetophenones;
aromatic ketone;
methyl ketone | antirheumatic drug;
EC 1.6.3.1. [NAD(P)H oxidase (H2O2-forming)] inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
peripheral nervous system drug;
plant metabolite | 2012 | 2016 | 10.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| aspirin | | benzoic acids;
phenyl acetates;
salicylates | anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| atenolol | | ethanolamines;
monocarboxylic acid amide;
propanolamine | anti-arrhythmia drug;
antihypertensive agent;
beta-adrenergic antagonist;
environmental contaminant;
sympatholytic agent;
xenobiotic | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| atrazine | | chloro-1,3,5-triazine;
diamino-1,3,5-triazine | environmental contaminant;
herbicide;
xenobiotic | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| bay-k-8644 | | (trifluoromethyl)benzenes;
C-nitro compound;
dihydropyridine;
methyl ester | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| benserazide | | carbohydrazide;
catechols;
primary alcohol;
primary amino compound | antiparkinson drug;
dopaminergic agent;
EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor | 2006 | 2017 | 12.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| benzo(a)pyrene | | ortho- and peri-fused polycyclic arene | carcinogenic agent;
mouse metabolite | 2020 | 2021 | 3.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| berberine | | alkaloid antibiotic;
berberine alkaloid;
botanical anti-fungal agent;
organic heteropentacyclic compound | antilipemic drug;
antineoplastic agent;
antioxidant;
EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitor;
EC 1.21.3.3 (reticuline oxidase) inhibitor;
EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor;
EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor;
EC 2.7.11.10 (IkappaB kinase) inhibitor;
EC 3.1.1.4 (phospholipase A2) inhibitor;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor;
EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
geroprotector;
hypoglycemic agent;
metabolite;
potassium channel blocker | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| diminazene | | carboxamidine;
triazene derivative | antiparasitic agent;
trypanocidal drug | 2010 | 2019 | 9.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| bisbenzimidazole | | bibenzimidazole;
N-methylpiperazine | anthelminthic drug;
fluorochrome | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| bumetanide | | amino acid;
benzoic acids;
sulfonamide | diuretic;
EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| caffeine | | purine alkaloid;
trimethylxanthine | adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic | 2012 | 2020 | 7.5 | low | 0 | 0 | 0 | 0 | 8 | 0 |
| candesartan | | benzimidazolecarboxylic acid;
biphenylyltetrazole | angiotensin receptor antagonist;
antihypertensive agent;
environmental contaminant;
xenobiotic | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| carbonyl cyanide m-chlorophenyl hydrazone | | hydrazone;
monochlorobenzenes;
nitrile | antibacterial agent;
geroprotector;
ionophore | 2008 | 2015 | 12.5 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| cetyltrimethylammonium ion | | quaternary ammonium ion | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| chloroquine | | aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound | anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug | 2009 | 2018 | 10.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| chlorpromazine | | organochlorine compound;
phenothiazines;
tertiary amine | anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
phenothiazine antipsychotic drug | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| chlorpyrifos | | chloropyridine;
organic thiophosphate | acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
insecticide;
xenobiotic | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| clioquinol | | monohydroxyquinoline;
organochlorine compound;
organoiodine compound | antibacterial agent;
antifungal agent;
antimicrobial agent;
antineoplastic agent;
antiprotozoal drug;
chelator;
copper chelator | 2016 | 2022 | 4.7 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| clobenpropit | | imidazoles;
imidothiocarbamic ester;
organochlorine compound | H3-receptor antagonist;
H4-receptor agonist | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| clonazepam | | 1,4-benzodiazepinone;
monochlorobenzenes | anticonvulsant;
anxiolytic drug;
GABA modulator | 2017 | 2018 | 6.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| conduritol epoxide | | cyclitol;
epoxide;
tetrol | | 2009 | 2021 | 9.5 | low | 0 | 0 | 0 | 1 | 8 | 1 |
| cypermethrin | | aromatic ether;
cyclopropanecarboxylate ester;
nitrile;
organochlorine compound | agrochemical;
molluscicide;
pyrethroid ester acaricide;
pyrethroid ester insecticide | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cystamine | | organic disulfide;
primary amino compound | EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitor | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dapi | | indoles | fluorochrome | 2005 | 2016 | 14.8 | low | 0 | 0 | 0 | 4 | 2 | 0 |
| decamethonium | | quaternary ammonium ion | muscle relaxant;
nicotinic acetylcholine receptor agonist | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| deferiprone | | 4-pyridones | iron chelator;
protective agent | 2017 | 2021 | 4.7 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| deferoxamine | | acyclic desferrioxamine | bacterial metabolite;
ferroptosis inhibitor;
iron chelator;
siderophore | 1999 | 2017 | 14.7 | low | 0 | 0 | 1 | 1 | 5 | 0 |
| dequalinium | | quinolinium ion | antifungal agent;
antineoplastic agent;
antiseptic drug;
mitochondrial NADH:ubiquinone reductase inhibitor | 2006 | 2008 | 16.7 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| desipramine | | dibenzoazepine;
secondary amino compound | adrenergic uptake inhibitor;
alpha-adrenergic antagonist;
antidepressant;
cholinergic antagonist;
drug allergen;
EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
H1-receptor antagonist;
serotonin uptake inhibitor | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| amphetamine | | primary amine | | 2000 | 2018 | 14.7 | low | 0 | 0 | 1 | 5 | 8 | 0 |
| ddt | | benzenoid aromatic compound;
chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide | bridged diphenyl acaricide;
carcinogenic agent;
endocrine disruptor;
persistent organic pollutant | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| dichlorvos | | alkenyl phosphate;
dialkyl phosphate;
organochlorine acaricide;
organophosphate insecticide | anthelminthic drug;
antibacterial agent;
antifungal agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| diphenyleneiodonium | | organic cation | | 2011 | 2012 | 12.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| dipyridamole | | piperidines;
pyrimidopyrimidine;
tertiary amino compound;
tetrol | adenosine phosphodiesterase inhibitor;
EC 3.5.4.4 (adenosine deaminase) inhibitor;
platelet aggregation inhibitor;
vasodilator agent | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| valproic acid | | branched-chain fatty acid;
branched-chain saturated fatty acid | anticonvulsant;
antimanic drug;
EC 3.5.1.98 (histone deacetylase) inhibitor;
GABA agent;
neuroprotective agent;
psychotropic drug;
teratogenic agent | 2006 | 2017 | 13.0 | low | 0 | 0 | 0 | 3 | 3 | 0 |
| racemetirosine | | | | 2002 | 2010 | 18.6 | low | 0 | 0 | 0 | 7 | 0 | 0 |
| dsp 4 | | | | 2020 | 2023 | 2.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| emodin | | trihydroxyanthraquinone | antineoplastic agent;
laxative;
plant metabolite;
tyrosine kinase inhibitor | 2020 | 2022 | 3.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| erythrosine | | | | 2000 | 2021 | 8.4 | low | 0 | 0 | 1 | 0 | 6 | 1 |
| felodipine | | dichlorobenzene;
dihydropyridine;
ethyl ester;
methyl ester | anti-arrhythmia drug;
antihypertensive agent;
calcium channel blocker;
vasodilator agent | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| fenofibrate | | aromatic ether;
chlorobenzophenone;
isopropyl ester;
monochlorobenzenes | antilipemic drug;
environmental contaminant;
geroprotector;
xenobiotic | 2007 | 2022 | 9.5 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| fenofibrate | | aromatic ether;
chlorobenzophenone;
isopropyl ester;
monochlorobenzenes | antilipemic drug;
environmental contaminant;
geroprotector;
xenobiotic | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| fluconazole | | conazole antifungal drug;
difluorobenzene;
tertiary alcohol;
triazole antifungal drug | environmental contaminant;
P450 inhibitor;
xenobiotic | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| flufenamic acid | | aromatic amino acid;
organofluorine compound | antipyretic;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| fluoxetine | | (trifluoromethyl)benzenes;
aromatic ether;
secondary amino compound | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| fluspirilene | | diarylmethane | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| vanoxerine | | ether;
N-alkylpiperazine;
organofluorine compound;
tertiary amino compound | dopamine uptake inhibitor | 2003 | 2018 | 13.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| glutaral | | dialdehyde | cross-linking reagent;
disinfectant;
fixative | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| glyphosate | | glycine derivative;
phosphonic acid | agrochemical;
EC 2.5.1.19 (3-phosphoshikimate 1-carboxyvinyltransferase) inhibitor;
herbicide | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| go 6976 | | indolocarbazole;
organic heterohexacyclic compound | EC 2.7.11.13 (protein kinase C) inhibitor | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| guanidine | | carboxamidine;
guanidines;
one-carbon compound | | 2005 | 2014 | 15.8 | low | 0 | 0 | 0 | 3 | 1 | 0 |
| gw8510 | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1-(5-isoquinolinesulfonyl)-2-methylpiperazine | | isoquinolines;
N-sulfonylpiperazine | EC 2.7.11.13 (protein kinase C) inhibitor | 2016 | 2022 | 6.5 | low | 0 | 0 | 0 | 0 | 3 | 1 |
| fasudil | | isoquinolines;
N-sulfonyldiazepane | antihypertensive agent;
calcium channel blocker;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
geroprotector;
neuroprotective agent;
nootropic agent;
vasodilator agent | 2016 | 2022 | 6.5 | low | 0 | 0 | 0 | 0 | 3 | 1 |
| haloperidol | | aromatic ketone;
hydroxypiperidine;
monochlorobenzenes;
organofluorine compound;
tertiary alcohol | antidyskinesia agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist | 2011 | 2023 | 6.0 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| beta-thujaplicin | | cyclic ketone;
enol;
monoterpenoid | antibacterial agent;
antifungal agent;
antineoplastic agent;
antiplasmodial drug;
plant metabolite | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ethidium | | phenanthridines | fluorochrome;
intercalator | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| hydroxyurea | | one-carbon compound;
ureas | antimetabolite;
antimitotic;
antineoplastic agent;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
genotoxin;
immunomodulator;
radical scavenger;
teratogenic agent | 2003 | 2011 | 17.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| ibuprofen | | monocarboxylic acid | antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
radical scavenger;
xenobiotic | 2010 | 2013 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| indole-3-carbinol | | indolyl alcohol | antineoplastic agent;
plant metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| indolepropionic acid | | indol-3-yl carboxylic acid | auxin;
human metabolite;
plant metabolite | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| isoflurane | | organofluorine compound | inhalation anaesthetic | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| juglone | | hydroxy-1,4-naphthoquinone | geroprotector;
herbicide;
reactive oxygen species generator | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| ketanserin | | aromatic ketone;
organofluorine compound;
piperidines;
quinazolines | alpha-adrenergic antagonist;
antihypertensive agent;
cardiovascular drug;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
serotonergic antagonist | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| kinetin | | 6-aminopurines;
furans | cytokinin;
geroprotector | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pyrrolidine-2,4-dicarboxylic acid | | | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| losartan | | biphenylyltetrazole;
imidazoles | angiotensin receptor antagonist;
anti-arrhythmia drug;
antihypertensive agent;
endothelin receptor antagonist | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one | | chromones;
morpholines;
organochlorine compound | autophagy inhibitor;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
geroprotector | 2002 | 2012 | 17.0 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| malathion | | diester;
ethyl ester;
organic thiophosphate | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| edaravone | | pyrazolone | antioxidant;
radical scavenger | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| meclofenoxate | | monocarboxylic acid | | 2016 | 2023 | 4.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| memantine | | adamantanes;
primary aliphatic amine | antidepressant;
antiparkinson drug;
dopaminergic agent;
neuroprotective agent;
NMDA receptor antagonist | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| vitamin k 3 | | 1,4-naphthoquinones;
vitamin K | angiogenesis inhibitor;
antineoplastic agent;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
human urinary metabolite;
nutraceutical | 2013 | 2018 | 8.3 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| metformin | | guanidines | environmental contaminant;
geroprotector;
hypoglycemic agent;
xenobiotic | 2014 | 2021 | 6.4 | low | 0 | 0 | 0 | 0 | 8 | 1 |
| methoxsalen | | aromatic ether;
psoralens | antineoplastic agent;
cross-linking reagent;
dermatologic drug;
photosensitizing agent;
plant metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| nocodazole | | aromatic ketone;
benzimidazoles;
carbamate ester;
thiophenes | antimitotic;
antineoplastic agent;
microtubule-destabilising agent;
tubulin modulator | 2004 | 2017 | 15.1 | low | 0 | 0 | 0 | 5 | 3 | 0 |
| methyl salicylate | | benzoate ester;
methyl ester;
salicylates | flavouring agent;
insect attractant;
metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| methylphenidate | | beta-amino acid ester;
methyl ester;
piperidines | | 2012 | 2020 | 9.3 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| molsidomine | | ethyl ester;
morpholines;
oxadiazole;
zwitterion | antioxidant;
apoptosis inhibitor;
cardioprotective agent;
nitric oxide donor;
vasodilator agent | 2003 | 2012 | 17.6 | low | 0 | 0 | 0 | 4 | 1 | 0 |
| apnea | | purine nucleoside | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| niclosamide | | benzamides;
C-nitro compound;
monochlorobenzenes;
salicylanilides;
secondary carboxamide | anthelminthic drug;
anticoronaviral agent;
antiparasitic agent;
apoptosis inducer;
molluscicide;
piscicide;
STAT3 inhibitor | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| nifedipine | | C-nitro compound;
dihydropyridine;
methyl ester | calcium channel blocker;
human metabolite;
tocolytic agent;
vasodilator agent | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nimesulide | | aromatic ether;
C-nitro compound;
sulfonamide | cyclooxygenase 2 inhibitor;
non-steroidal anti-inflammatory drug | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nomifensine | | isoquinolines | dopamine uptake inhibitor | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| nortriptyline | | organic tricyclic compound;
secondary amine | adrenergic uptake inhibitor;
analgesic;
antidepressant;
antineoplastic agent;
apoptosis inducer;
drug metabolite | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| octopamine | | phenylethanolamines;
tyramines | neurotransmitter | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| oxidopamine | | benzenetriol;
catecholamine;
primary amino compound | drug metabolite;
human metabolite;
neurotoxin | 2000 | 2023 | 10.1 | low | 0 | 0 | 1 | 26 | 53 | 18 |
| aminosalicylic acid | | aminobenzoic acid;
phenols | antitubercular agent | 2003 | 2023 | 11.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| quinone | | 1,4-benzoquinones | cofactor;
human xenobiotic metabolite;
mouse metabolite | 2010 | 2023 | 8.0 | low | 0 | 0 | 0 | 1 | 1 | 1 |
| palmidrol | | endocannabinoid;
N-(long-chain-acyl)ethanolamine;
N-(saturated fatty acyl)ethanolamine | anti-inflammatory drug;
anticonvulsant;
antihypertensive agent;
neuroprotective agent | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| papaverine | | benzylisoquinoline alkaloid;
dimethoxybenzene;
isoquinolines | antispasmodic drug;
vasodilator agent | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pargyline | | aromatic amine | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pd 98059 | | aromatic amine;
monomethoxyflavone | EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
geroprotector | 2002 | 2015 | 15.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| pemoline | | 1,3-oxazoles | central nervous system stimulant | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-phenylbutyric acid | | monocarboxylic acid | antineoplastic agent;
apoptosis inducer;
EC 3.5.1.98 (histone deacetylase) inhibitor;
prodrug | 2006 | 2022 | 11.0 | low | 0 | 0 | 0 | 3 | 2 | 1 |
| phenylmethylsulfonyl fluoride | | acyl fluoride | serine proteinase inhibitor | 2003 | 2020 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| o-phthalaldehyde | | benzaldehydes;
dialdehyde | epitope | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pioglitazone | | aromatic ether;
pyridines;
thiazolidinediones | antidepressant;
cardioprotective agent;
EC 2.7.1.33 (pantothenate kinase) inhibitor;
EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor;
ferroptosis inhibitor;
geroprotector;
hypoglycemic agent;
insulin-sensitizing drug;
PPARgamma agonist;
xenobiotic | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| potassium chloride | | inorganic chloride;
inorganic potassium salt;
potassium salt | fertilizer | 2009 | 2021 | 8.2 | low | 0 | 0 | 0 | 1 | 2 | 1 |
| 4-aminobenzoic acid | | aminobenzoate;
aromatic amino-acid anion | Escherichia coli metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| prazosin | | aromatic ether;
furans;
monocarboxylic acid amide;
piperazines;
quinazolines | alpha-adrenergic antagonist;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor | 2002 | 2022 | 12.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| probenecid | | benzoic acids;
sulfonamide | uricosuric drug | 2002 | 2019 | 8.6 | low | 0 | 0 | 0 | 1 | 6 | 0 |
| probucol | | dithioketal;
polyphenol | anti-inflammatory drug;
anticholesteremic drug;
antilipemic drug;
antioxidant;
cardiovascular drug | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| propofol | | phenols | anticonvulsant;
antiemetic;
intravenous anaesthetic;
radical scavenger;
sedative | 2017 | 2020 | 5.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| propranolol | | naphthalenes;
propanolamine;
secondary amine | anti-arrhythmia drug;
antihypertensive agent;
anxiolytic drug;
beta-adrenergic antagonist;
environmental contaminant;
human blood serum metabolite;
vasodilator agent;
xenobiotic | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| opc 12759 | | secondary carboxamide | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| riluzole | | benzothiazoles | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| rolipram | | pyrrolidin-2-ones | antidepressant;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ropinirole | | indolones;
tertiary amine | antidyskinesia agent;
antiparkinson drug;
central nervous system drug;
dopamine agonist | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| saccharin | | 1,2-benzisothiazole;
N-sulfonylcarboxamide | environmental contaminant;
sweetening agent;
xenobiotic | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sb 202190 | | imidazoles;
organofluorine compound;
phenols;
pyridines | apoptosis inducer;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| linsidomine | | morpholines | | 2003 | 2012 | 17.6 | low | 0 | 0 | 0 | 4 | 1 | 0 |
| sk&f 86002 | | imidazoles | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| sulfaphenazole | | primary amino compound;
pyrazoles;
substituted aniline;
sulfonamide antibiotic;
sulfonamide | antibacterial drug;
EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor;
EC 1.14.13.67 (quinine 3-monooxygenase) inhibitor;
P450 inhibitor | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sulforaphane | | isothiocyanate;
sulfoxide | antineoplastic agent;
antioxidant;
EC 3.5.1.98 (histone deacetylase) inhibitor;
plant metabolite | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| talipexole | | azepine | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| terazosin | | furans;
piperazines;
primary amino compound;
quinazolines | alpha-adrenergic antagonist;
antihypertensive agent;
antineoplastic agent | 2002 | 2022 | 12.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| thalidomide | | phthalimides;
piperidones | | 2015 | 2022 | 6.0 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| trifluoperazine | | N-alkylpiperazine;
N-methylpiperazine;
organofluorine compound;
phenothiazines | antiemetic;
calmodulin antagonist;
dopaminergic antagonist;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor;
EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor;
phenothiazine antipsychotic drug | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| trihexyphenidyl | | amine | | 2007 | 2012 | 14.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| tyramine | | monoamine molecular messenger;
primary amino compound;
tyramines | EC 3.1.1.8 (cholinesterase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| zinc chloride | | inorganic chloride;
zinc molecular entity | astringent;
disinfectant;
EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor;
Lewis acid | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| zonisamide | | 1,2-benzoxazoles;
sulfonamide | anticonvulsant;
antioxidant;
central nervous system drug;
protective agent;
T-type calcium channel blocker | 2008 | 2014 | 13.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| corticosterone | | 11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone | human metabolite;
mouse metabolite | 2015 | 2019 | 6.5 | low | 0 | 0 | 0 | 0 | 6 | 0 |
| estriol | | 16alpha-hydroxy steroid;
17beta-hydroxy steroid;
3-hydroxy steroid | estrogen;
human metabolite;
human xenobiotic metabolite;
mouse metabolite | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| reserpine | | alkaloid ester;
methyl ester;
yohimban alkaloid | adrenergic uptake inhibitor;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
first generation antipsychotic;
plant metabolite;
xenobiotic | 2003 | 2023 | 9.5 | low | 0 | 0 | 0 | 2 | 1 | 3 |
| benzimidazole | | benzimidazole;
polycyclic heteroarene | | 2013 | 2017 | 9.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| dextroamphetamine | | 1-phenylpropan-2-amine | adrenergic agent;
adrenergic uptake inhibitor;
dopamine uptake inhibitor;
dopaminergic agent;
neurotoxin;
sympathomimetic agent | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| carbachol | | ammonium salt;
carbamate ester | cardiotonic drug;
miotic;
muscarinic agonist;
nicotinic acetylcholine receptor agonist;
non-narcotic analgesic | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dichlororibofuranosylbenzimidazole | | | | 2004 | 2005 | 19.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| pilocarpine | | pilocarpine | antiglaucoma drug | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pentylenetetrazole | | organic heterobicyclic compound;
organonitrogen heterocyclic compound | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| alanine | | alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid | EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite | 1998 | 2021 | 16.1 | low | 0 | 0 | 6 | 31 | 12 | 1 |
| serine | | L-alpha-amino acid;
proteinogenic amino acid;
serine family amino acid;
serine zwitterion;
serine | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1999 | 2023 | 11.4 | low | 0 | 0 | 2 | 39 | 46 | 12 |
| aspartic acid | | aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid | Escherichia coli metabolite;
mouse metabolite;
neurotransmitter | 2000 | 2018 | 14.7 | low | 0 | 0 | 1 | 5 | 3 | 0 |
| glutamine | | amino acid zwitterion;
glutamine family amino acid;
glutamine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid | EC 1.14.13.39 (nitric oxide synthase) inhibitor;
Escherichia coli metabolite;
human metabolite;
metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite | 2004 | 2021 | 11.1 | low | 0 | 0 | 0 | 3 | 6 | 1 |
| lysine | | aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid | algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2004 | 2023 | 11.5 | low | 0 | 0 | 0 | 16 | 24 | 2 |
| physostigmine | | carbamate ester;
indole alkaloid | antidote to curare poisoning;
EC 3.1.1.8 (cholinesterase) inhibitor;
miotic | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| sulfamic acid | | sulfamic acids | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| sucrose | | glycosyl glycoside | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent | 2011 | 2017 | 10.5 | low | 0 | 0 | 0 | 0 | 4 | 0 |
| apomorphine | | aporphine alkaloid | alpha-adrenergic drug;
antidyskinesia agent;
antiparkinson drug;
dopamine agonist;
emetic;
serotonergic drug | 2004 | 2022 | 10.4 | low | 0 | 0 | 0 | 4 | 9 | 3 |
| tetrabenazine | | benzoquinolizine;
cyclic ketone;
tertiary amino compound | | 2007 | 2018 | 10.0 | low | 0 | 0 | 0 | 1 | 4 | 0 |
| adenosine diphosphate | | adenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate | fundamental metabolite;
human metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| uridine | | uridines | drug metabolite;
fundamental metabolite;
human metabolite | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| kanamycin a | | kanamycins | bacterial metabolite | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| bromodeoxyuridine | | pyrimidine 2'-deoxyribonucleoside | antimetabolite;
antineoplastic agent | 2003 | 2022 | 9.5 | low | 0 | 0 | 0 | 1 | 4 | 1 |
| galactose | | D-galactose;
galactopyranose | Escherichia coli metabolite;
mouse metabolite | 2014 | 2019 | 7.7 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| carbostyril | | monohydroxyquinoline;
quinolone | bacterial xenobiotic metabolite | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| levodopa | | amino acid zwitterion;
dopa;
L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid | allelochemical;
antidyskinesia agent;
antiparkinson drug;
dopaminergic agent;
hapten;
human metabolite;
mouse metabolite;
neurotoxin;
plant growth retardant;
plant metabolite;
prodrug | 1999 | 2023 | 10.6 | low | 0 | 0 | 1 | 27 | 38 | 13 |
| edetic acid | | ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid | anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector | 2003 | 2014 | 15.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| phenylethyl alcohol | | benzenes;
primary alcohol | Aspergillus metabolite;
fragrance;
plant growth retardant;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2014 | 2023 | 4.4 | low | 0 | 0 | 0 | 0 | 6 | 3 |
| tyrosine | | amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine | EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical | 2000 | 2022 | 13.6 | low | 0 | 0 | 3 | 47 | 34 | 10 |
| cysteamine | | amine;
thiol | geroprotector;
human metabolite;
mouse metabolite;
radiation protective agent | 2015 | 2020 | 6.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| adenosine monophosphate | | adenosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate | adenosine A1 receptor agonist;
cofactor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.11 (fructose-bisphosphatase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical | 2018 | 2019 | 5.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| methylene blue | | organic chloride salt | acid-base indicator;
antidepressant;
antimalarial;
antimicrobial agent;
antioxidant;
cardioprotective agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 4.6.1.2 (guanylate cyclase) inhibitor;
fluorochrome;
histological dye;
neuroprotective agent;
physical tracer | 2019 | 2022 | 3.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| leucine | | amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2004 | 2023 | 7.3 | low | 0 | 0 | 0 | 1 | 2 | 3 |
| aniline | | anilines;
primary arylamine | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| methionine | | aspartate family amino acid;
L-alpha-amino acid;
methionine zwitterion;
methionine;
proteinogenic amino acid | antidote to paracetamol poisoning;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical | 2002 | 2023 | 11.3 | low | 0 | 0 | 0 | 13 | 15 | 3 |
| 1,2-dipalmitoylphosphatidylcholine | | | | 2007 | 2018 | 9.8 | low | 0 | 0 | 0 | 1 | 4 | 0 |
| phenylalanine | | amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid | algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2004 | 2022 | 7.3 | low | 0 | 0 | 0 | 1 | 3 | 2 |
| colchicine | | alkaloid;
colchicine | anti-inflammatory agent;
gout suppressant;
mutagen | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cytidine triphosphate | | cytidine 5'-phosphate;
pyrimidine ribonucleoside 5'-triphosphate | Escherichia coli metabolite;
mouse metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| strophanthidin | | 14beta-hydroxy steroid;
19-oxo steroid;
3beta-hydroxy steroid;
5beta-hydroxy steroid;
cardenolides;
steroid aldehyde | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cycloheximide | | antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol | anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| egtazic acid | | diether;
tertiary amino compound;
tetracarboxylic acid | chelator | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dimethylformamide | | formamides;
volatile organic compound | geroprotector;
hepatotoxic agent;
polar aprotic solvent | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| mannitol | | mannitol | allergen;
antiglaucoma drug;
compatible osmolytes;
Escherichia coli metabolite;
food anticaking agent;
food bulking agent;
food humectant;
food stabiliser;
food thickening agent;
hapten;
metabolite;
osmotic diuretic;
sweetening agent | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cytarabine | | beta-D-arabinoside;
monosaccharide derivative;
pyrimidine nucleoside | antimetabolite;
antineoplastic agent;
antiviral agent;
immunosuppressive agent | 2003 | 2005 | 20.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| asparagine | | amino acid zwitterion;
asparagine;
aspartate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid | Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2009 | 2018 | 10.0 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| histidine | | amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid | algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite | 2004 | 2023 | 10.8 | low | 0 | 0 | 0 | 7 | 15 | 2 |
| 1,1,1-trichloroethane | | chloroethanes | polar solvent | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| valine | | L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid;
valine | algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite | 2003 | 2012 | 17.0 | low | 0 | 0 | 0 | 6 | 1 | 0 |
| threonine | | amino acid zwitterion;
aspartate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
threonine | algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1998 | 2022 | 14.2 | low | 0 | 0 | 5 | 15 | 11 | 2 |
| tryptophan | | erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan | antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2004 | 2022 | 12.0 | low | 0 | 0 | 0 | 10 | 12 | 2 |
| isoleucine | | aspartate family amino acid;
isoleucine;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| arginine | | arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid | biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical | 2008 | 2022 | 8.0 | low | 0 | 0 | 0 | 1 | 4 | 1 |
| acetonitrile | | aliphatic nitrile;
volatile organic compound | EC 3.5.1.4 (amidase) inhibitor;
NMR chemical shift reference compound;
polar aprotic solvent | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| methylene chloride | | chloromethanes;
volatile organic compound | carcinogenic agent;
polar aprotic solvent;
refrigerant | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| trifluoroethanol | | fluoroalcohol | | 2002 | 2018 | 13.3 | low | 0 | 0 | 0 | 3 | 6 | 0 |
| tert-butylhydroperoxide | | alkyl hydroperoxide | antibacterial agent;
oxidising agent | 2013 | 2021 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| trifluoroacetic acid | | fluoroalkanoic acid | human xenobiotic metabolite;
NMR chemical shift reference compound;
reagent | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| trichloroethylene | | chloroethenes | inhalation anaesthetic;
mouse metabolite | 2010 | 2021 | 7.0 | low | 0 | 0 | 0 | 1 | 2 | 1 |
| acrylamide | | acrylamides;
N-acylammonia;
primary carboxamide | alkylating agent;
carcinogenic agent;
Maillard reaction product;
mutagen;
neurotoxin | 2006 | 2016 | 12.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| rotenone | | organic heteropentacyclic compound;
rotenones | antineoplastic agent;
metabolite;
mitochondrial NADH:ubiquinone reductase inhibitor;
phytogenic insecticide;
piscicide;
toxin | 2001 | 2023 | 9.2 | low | 0 | 0 | 0 | 50 | 94 | 40 |
| diquat | | organic cation | defoliant;
herbicide | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| pyocyanine | | iminium betaine;
phenazines | antibacterial agent;
bacterial metabolite;
biological pigment;
virulence factor | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| n-vinyl-2-pyrrolidinone | | pyrrolidin-2-ones | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dinoseb | | dinitrophenol | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| salicylaldehyde | | hydroxybenzaldehyde | nematicide;
plant metabolite | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| isatin | | indoledione | EC 1.4.3.4 (monoamine oxidase) inhibitor;
plant metabolite | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 2-naphthylamine | | naphthylamine | carcinogenic agent | 2003 | 2020 | 11.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| 2-methylquinoline | | quinolines | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| diphenyl | | aromatic fungicide;
benzenes;
biphenyls | antifungal agrochemical;
antimicrobial food preservative | 2017 | 2020 | 5.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| xanthenes | | xanthene | | 2014 | 2017 | 8.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| pyrrolidonecarboxylic acid | | 5-oxoproline;
L-proline derivative;
non-proteinogenic L-alpha-amino acid | algal metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| trehalose | | trehalose | Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2007 | 2023 | 7.5 | low | 0 | 0 | 0 | 1 | 18 | 3 |
| styrene | | styrenes;
vinylarene;
volatile organic compound | mouse metabolite;
mutagen;
plant metabolite | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| quinuclidines | | quinuclidines;
saturated organic heterobicyclic parent | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-phenylenediamine | | phenylenediamine | allergen;
dye;
hapten;
reagent | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| acrolein | | enal | herbicide;
human xenobiotic metabolite;
toxin | 2007 | 2021 | 7.6 | low | 0 | 0 | 0 | 1 | 3 | 1 |
| acrylonitrile | | aliphatic nitrile;
volatile organic compound | antifungal agent;
carcinogenic agent;
fungal metabolite;
mutagen;
polar aprotic solvent | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| glyoxal | | dialdehyde | agrochemical;
allergen;
pesticide;
plant growth regulator | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| diisobutylene | | | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2-methylpentane | | alkane | | 2008 | 2011 | 14.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| n-pentanoic acid | | short-chain fatty acid;
straight-chain saturated fatty acid | plant metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pyrroles | | pyrrole;
secondary amine | | 2012 | 2018 | 8.5 | low | 0 | 0 | 0 | 0 | 6 | 0 |
| thiophenes | | mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound | non-polar solvent | 2013 | 2020 | 6.2 | low | 0 | 0 | 0 | 0 | 5 | 0 |
| ethyl stearate | | long-chain fatty acid ethyl ester;
octadecanoate ester | plant metabolite | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| n-methylpyrrolidine | | | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pyrazolanthrone | | anthrapyrazole;
aromatic ketone;
cyclic ketone | antineoplastic agent;
c-Jun N-terminal kinase inhibitor;
geroprotector | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1,4-naphthoquinone | | 1,4-naphthoquinones | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| protocatechualdehyde | | dihydroxybenzaldehyde | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2-hydroxypyridine | | monohydroxypyridine | plant metabolite | 2012 | 2021 | 7.8 | low | 0 | 0 | 0 | 0 | 4 | 1 |
| ditiocarb | | dithiocarbamic acids | chelator;
copper chelator | 2001 | 2004 | 21.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| potassium cyanide | | cyanide salt;
one-carbon compound;
potassium salt | EC 1.15.1.1 (superoxide dismutase) inhibitor;
EC 1.9.3.1 (cytochrome c oxidase) inhibitor;
neurotoxin | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| catechin | | catechin | antioxidant;
plant metabolite | 2004 | 2023 | 8.2 | low | 0 | 0 | 0 | 9 | 29 | 7 |
| quinazolines | | azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinazolines | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| indazoles | | indazole | | 2019 | 2021 | 4.0 | low | 0 | 0 | 0 | 0 | 2 | 2 |
| benzoxazoles | | 1,3-benzoxazoles;
mancude organic heterobicyclic parent | | 2009 | 2021 | 9.0 | low | 0 | 0 | 0 | 2 | 3 | 1 |
| cyclopentane | | cycloalkane;
cyclopentanes;
volatile organic compound | non-polar solvent | 2006 | 2019 | 9.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| isoxazoles | | isoxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene | | 2008 | 2014 | 12.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| oxazoles | | 1,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene | | 2018 | 2023 | 3.0 | low | 0 | 0 | 0 | 0 | 1 | 2 |
| thiazoles | | 1,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene | | 1998 | 2022 | 14.0 | low | 0 | 0 | 7 | 60 | 51 | 3 |
| 1,2,4-triazole | | 1,2,4-triazole | | 2020 | 2022 | 3.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| pyrazines | | diazine;
pyrazines | Daphnia magna metabolite | 2018 | 2019 | 5.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| hydrazine | | azane;
hydrazines | EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor | 2009 | 2010 | 14.3 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| evans blue | | organic sodium salt | fluorochrome;
histological dye;
sodium channel blocker;
teratogenic agent | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| azacitidine | | N-glycosyl-1,3,5-triazine;
nucleoside analogue | antineoplastic agent | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| diazomethane | | diazo compound | alkylating agent;
antineoplastic agent;
carcinogenic agent;
poison | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 5-fluorotryptophan | | non-proteinogenic alpha-amino acid;
organofluorine compound;
tryptophan derivative | | 2006 | 2012 | 15.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| galantamine | | benzazepine alkaloid fundamental parent;
benzazepine alkaloid;
organic heterotetracyclic compound;
tertiary amino compound | antidote to curare poisoning;
cholinergic drug;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
plant metabolite | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| aminoimidazole carboxamide | | aminoimidazole;
monocarboxylic acid amide | mouse metabolite | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cuprizone | | organonitrogen compound;
organooxygen compound | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-methylcatechol | | methylcatechol | antioxidant;
carcinogenic agent;
hapten;
human metabolite;
plant metabolite | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| fusarium | | | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| bicuculline | | benzylisoquinoline alkaloid;
isoquinoline alkaloid;
isoquinolines | agrochemical;
central nervous system stimulant;
GABA-gated chloride channel antagonist;
GABAA receptor antagonist;
neurotoxin | 2010 | 2017 | 10.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| vasicinone | | | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| kainic acid | | dicarboxylic acid;
L-proline derivative;
non-proteinogenic L-alpha-amino acid;
pyrrolidinecarboxylic acid | antinematodal drug;
excitatory amino acid agonist | 2001 | 2021 | 12.0 | low | 0 | 0 | 0 | 1 | 2 | 1 |
| thymoquinone | | 1,4-benzoquinones | adjuvant;
anti-inflammatory agent;
antidepressant;
antineoplastic agent;
antioxidant;
cardioprotective agent;
plant metabolite | 2014 | 2019 | 8.3 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| diphenoquinone | | | | 2012 | 2012 | 12.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| indan | | indanes;
ortho-fused bicyclic hydrocarbon | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| butenolide | | butenolide | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 4-hydroxyphenylethanol | | phenols | anti-arrhythmia drug;
antioxidant;
cardiovascular drug;
fungal metabolite;
geroprotector;
plant metabolite;
protective agent | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| alpha-aminopyridine | | | | 2017 | 2018 | 6.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| thiazolidines | | thiazolidine | | 2008 | 2013 | 13.5 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| mustard gas | | ethyl sulfide;
organochlorine compound | alkylating agent;
carcinogenic agent;
vesicant | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cyanogen bromide | | | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| oleanolic acid | | hydroxy monocarboxylic acid;
pentacyclic triterpenoid | plant metabolite | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| tetranitromethane | | organonitrogen compound | | 2003 | 2005 | 20.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| hematoxylin | | organic heterotetracyclic compound;
oxacycle;
polyphenol;
tertiary alcohol | histological dye;
plant metabolite | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| hesperidin | | 3'-hydroxyflavanones;
4'-methoxyflavanones;
dihydroxyflavanone;
disaccharide derivative;
flavanone glycoside;
monomethoxyflavanone;
rutinoside | mutagen | 2021 | 2023 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| androstenediol | | 17beta-hydroxy steroid;
3beta-hydroxy-Delta(5)-steroid | androgen;
human metabolite;
mouse metabolite;
radiation protective agent | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| luminol | | | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| flavone | | flavones | metabolite;
nematicide | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| tropolone | | alpha-hydroxy ketone;
cyclic ketone;
enol | bacterial metabolite;
fungicide;
toxin | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4,6-dinitro-o-cresol | | dinitrophenol acaricide;
hydroxytoluene;
nitrotoluene | dinitrophenol insecticide;
fungicide;
herbicide | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| methoxyhydroxyphenylglycol | | methoxybenzenes;
phenols | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| methamphetamine | | amphetamines;
secondary amine | central nervous system stimulant;
environmental contaminant;
neurotoxin;
psychotropic drug;
xenobiotic | 2003 | 2022 | 10.0 | low | 0 | 0 | 0 | 11 | 18 | 5 |
| dicyclohexylcarbodiimide | | carbodiimide | ATP synthase inhibitor;
cross-linking reagent;
peptide coupling reagent | 1998 | 2000 | 25.2 | low | 0 | 0 | 4 | 0 | 0 | 0 |
| maleimide | | dicarboximide;
maleimides | EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| malondialdehyde | | dialdehyde | biomarker | 2005 | 2022 | 9.7 | low | 0 | 0 | 0 | 4 | 7 | 2 |
| eosine yellowish-(ys) | | organic sodium salt;
organobromine compound | fluorochrome;
histological dye | 2000 | 2009 | 20.6 | low | 0 | 0 | 1 | 4 | 0 | 0 |
| lithium carbonate | | carbonate salt;
lithium salt | antimanic drug | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| congo red | | bis(azo) compound | | 2000 | 2019 | 12.5 | low | 0 | 0 | 1 | 4 | 6 | 0 |
| 3-hydroxyflavone | | flavonols;
monohydroxyflavone | | 2012 | 2021 | 5.3 | low | 0 | 0 | 0 | 0 | 4 | 2 |
| 1,3-indandione | | aromatic ketone;
beta-diketone;
indanones | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| acetylcysteine | | acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid | antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary | 1999 | 2021 | 14.8 | low | 0 | 0 | 1 | 20 | 11 | 1 |
| c.i. 42510 | | | | 2001 | 2020 | 11.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| 2-chloroethyl ethyl sulfide | | | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| hexafluoroisopropanol | | organofluorine compound;
secondary alcohol | drug metabolite | 2003 | 2018 | 15.4 | low | 0 | 0 | 0 | 4 | 3 | 0 |
| cyclopentenone | | alicyclic ketone;
enone | Hsp70 inducer | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1-methylpyridinium | | methylpyridines | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cytidine diphosphate choline | | nucleotide-(amino alcohol)s;
phosphocholines | human metabolite;
mouse metabolite;
neuroprotective agent;
psychotropic drug;
Saccharomyces cerevisiae metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tetramethylpyrazine | | alkaloid;
pyrazines | antineoplastic agent;
apoptosis inhibitor;
bacterial metabolite;
neuroprotective agent;
platelet aggregation inhibitor;
vasodilator agent | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| zinc oxide | | zinc molecular entity | | 2020 | 2021 | 3.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| molybdenum disulfide | | sulfide salt | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| glycyrrhizic acid | | enone;
glucosiduronic acid;
pentacyclic triterpenoid;
tricarboxylic acid;
triterpenoid saponin | EC 3.4.21.5 (thrombin) inhibitor;
plant metabolite | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| d-alpha tocopherol | | alpha-tocopherol | algal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite | 2008 | 2014 | 13.2 | low | 1 | 0 | 0 | 2 | 3 | 0 |
| selenomethionine | | selenoamino acid;
selenomethionines | plant metabolite | 2005 | 2021 | 11.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| paraquat | | organic cation | geroprotector;
herbicide | 2001 | 2023 | 10.8 | low | 0 | 0 | 0 | 17 | 22 | 10 |
| s,n,n'-tripropylthiocarbamate | | tertiary amine | | 2006 | 2019 | 11.8 | low | 0 | 0 | 0 | 2 | 3 | 0 |
| 2-tert-butylhydroquinone | | hydroquinones | food antioxidant | 2017 | 2021 | 5.3 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| 5-hydroxyindole | | hydroxyindoles | human metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| azetidyl-2-carboxylic acid | | azetidine-2-carboxylic acid | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| diallyl disulfide | | organic disulfide | antifungal agent;
antineoplastic agent;
plant metabolite | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| n-isopropylacrylamide | | | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| fluorescein | | 2-benzofurans;
gamma-lactone;
organic heteropentacyclic compound;
oxaspiro compound;
polyphenol;
xanthene dye | fluorescent dye;
radioopaque medium | 2020 | 2022 | 3.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| fast green fcf | | organic sodium salt | fluorochrome;
food colouring;
histological dye | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| thioflavin t | | organic chloride salt | fluorochrome;
geroprotector;
histological dye | 1998 | 2022 | 11.4 | low | 0 | 0 | 5 | 45 | 66 | 9 |
| c.i. direct blue 1 | | | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| dicloxacillin | | dichlorobenzene;
penicillin | antibacterial drug | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| mannose | | D-aldohexose;
D-mannose;
mannopyranose | metabolite | 2013 | 2022 | 6.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| dithiothreitol | | 1,4-dimercaptobutane-2,3-diol;
butanediols;
dithiol;
glycol;
thiol | chelator;
human metabolite;
reducing agent | 2000 | 2008 | 21.3 | low | 0 | 0 | 2 | 1 | 0 | 0 |
| tranylcypromine | | 2-phenylcyclopropan-1-amine | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3-phenoxybenzoic acid | | phenoxybenzoic acid | human xenobiotic metabolite;
marine xenobiotic metabolite | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| carbonates | | carbon oxoanion | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| buthionine sulfoximine | | diastereoisomeric mixture;
homocysteines;
non-proteinogenic alpha-amino acid;
sulfoximide | EC 6.3.2.2 (glutamate--cysteine ligase) inhibitor;
ferroptosis inducer | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| n-methylaspartate | | amino dicarboxylic acid;
D-alpha-amino acid;
D-aspartic acid derivative;
secondary amino compound | neurotransmitter agent | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dysprosium | | f-block element atom;
lanthanoid atom | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| iridium | | cobalt group element atom;
platinum group metal atom | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| manganese | | elemental manganese;
manganese group element atom | Escherichia coli metabolite;
micronutrient | 2005 | 2023 | 8.4 | low | 0 | 0 | 0 | 5 | 32 | 5 |
| mercury | | elemental mercury;
zinc group element atom | neurotoxin | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| molybdenum | | chromium group element atom | micronutrient | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| palladium | | metal allergen;
nickel group element atom;
platinum group metal atom | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| platinum | | elemental platinum;
nickel group element atom;
platinum group metal atom | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ruthenium | | iron group element atom;
platinum group metal atom | | 2017 | 2023 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| silver | | copper group element atom;
elemental silver | Escherichia coli metabolite | 1998 | 2023 | 10.8 | low | 0 | 0 | 1 | 0 | 2 | 1 |
| terbium | | f-block element atom;
lanthanoid atom | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| titanium | | titanium group element atom | | 2010 | 2020 | 9.0 | low | 0 | 0 | 0 | 1 | 4 | 0 |
| cadmium | | cadmium molecular entity;
zinc group element atom | | 2004 | 2021 | 11.5 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| cerium | | f-block element atom;
lanthanoid atom | | 2018 | 2019 | 5.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| chromium | | chromium group element atom;
metal allergen | micronutrient | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| gold | | copper group element atom;
elemental gold | | 2008 | 2023 | 6.6 | low | 0 | 0 | 0 | 2 | 26 | 11 |
| vanadium | | elemental vanadium;
vanadium group element atom | micronutrient | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| aluminum chloride | | aluminium coordination entity | Lewis acid | 2002 | 2021 | 12.5 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| cupric chloride | | copper molecular entity;
inorganic chloride | EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor | 2000 | 2015 | 16.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| acetylglucosamine | | N-acetyl-D-glucosamine | epitope | 2012 | 2021 | 6.2 | low | 0 | 0 | 0 | 0 | 10 | 2 |
| ferric chloride | | iron coordination entity | astringent;
Lewis acid | 1999 | 2000 | 24.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| nickel chloride | | nickel coordination entity | calcium channel blocker;
hapten | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ferrous sulfate | | iron molecular entity;
metal sulfate | reducing agent | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| calcium phosphate, monobasic, anhydrous | | calcium phosphate | fertilizer | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tricalcium phosphate | | calcium phosphate | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ferrous chloride | | iron coordination entity | | 1999 | 2020 | 16.9 | low | 0 | 0 | 1 | 5 | 2 | 0 |
| copper sulfate | | metal sulfate | emetic;
fertilizer;
sensitiser | 2011 | 2017 | 10.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| deuterium | | dihydrogen | | 2011 | 2022 | 7.3 | low | 0 | 0 | 0 | 0 | 5 | 2 |
| fluorine | | diatomic fluorine;
gas molecular entity | NMR chemical shift reference compound | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ferric sulfate | | iron molecular entity;
metal sulfate | astringent;
catalyst;
mordant | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| aluminum sulfate | | aluminium sulfate | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cadmium chloride | | cadmium coordination entity | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-chloro-7-nitrobenzofurazan | | benzoxadiazole;
C-nitro compound;
organochlorine compound | EC 1.4.3.4 (monoamine oxidase) inhibitor;
EC 3.6.1.3 (adenosinetriphosphatase) inhibitor;
fluorescent probe;
fluorochrome | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ammonium chloride | | ammonium salt;
inorganic chloride | ferroptosis inhibitor | 2001 | 2021 | 12.6 | low | 0 | 0 | 0 | 4 | 2 | 1 |
| titanium dioxide | | titanium oxides | food colouring | 2012 | 2017 | 9.0 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| selegiline | | selegiline;
terminal acetylenic compound | geroprotector | 2003 | 2022 | 9.9 | low | 1 | 0 | 0 | 3 | 7 | 3 |
| eedq | | | | 1998 | 2003 | 23.8 | low | 0 | 0 | 4 | 2 | 0 | 0 |
| tetradecanoylphorbol acetate | | acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester | antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator | 2001 | 2014 | 18.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| 18-crown-6 | | crown ether;
saturated organic heteromonocyclic parent | phase-transfer catalyst | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1-deoxynojirimycin | | 2-(hydroxymethyl)piperidine-3,4,5-triol;
piperidine alkaloid | anti-HIV agent;
anti-obesity agent;
bacterial metabolite;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
hepatoprotective agent;
hypoglycemic agent;
plant metabolite | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| phosphotyrosine | | L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid;
O(4)-phosphotyrosine | Escherichia coli metabolite;
immunogen | 2005 | 2021 | 10.0 | low | 0 | 0 | 0 | 1 | 1 | 1 |
| bromocriptine | | indole alkaloid | antidyskinesia agent;
antiparkinson drug;
dopamine agonist;
hormone antagonist | 2002 | 2007 | 19.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| cetalkonium chloride | | | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| zingerone | | methyl ketone;
monomethoxybenzene;
phenols | anti-inflammatory agent;
antiemetic;
antioxidant;
flavouring agent;
fragrance;
plant metabolite;
radiation protective agent | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| phenyl acetate | | benzenes;
phenyl acetates | | 2005 | 2021 | 7.0 | low | 0 | 0 | 0 | 1 | 6 | 1 |
| cetylpyridinium chloride anhydrous | | chloride salt;
organic chloride salt | antiseptic drug;
surfactant | 2012 | 2018 | 9.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| myrcene | | monoterpene | anabolic agent;
anti-inflammatory agent;
flavouring agent;
fragrance;
plant metabolite;
volatile oil component | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| pyrrolidine | | azacycloalkane;
pyrrolidines;
saturated organic heteromonocyclic parent | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pyrene | | ortho- and peri-fused polycyclic arene | fluorescent probe;
persistent organic pollutant | 2008 | 2019 | 10.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| transferrin | | | | 2007 | 2020 | 9.3 | low | 0 | 0 | 0 | 2 | 8 | 0 |
| alkenes | | | | 2020 | 2022 | 3.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| glutamic acid | | glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid | Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical | 2000 | 2023 | 10.9 | low | 0 | 0 | 1 | 14 | 15 | 5 |
| torpedo | | | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sodium azide | | inorganic sodium salt | antibacterial agent;
explosive;
mitochondrial respiratory-chain inhibitor;
mutagen | 2005 | 2008 | 17.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| azides | | pseudohalide anion | mitochondrial respiratory-chain inhibitor | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| nigericin | | polycyclic ether | antibacterial agent;
antimicrobial agent;
bacterial metabolite;
potassium ionophore | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 5,7-dihydroxytryptamine | | | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| paclitaxel | | taxane diterpenoid;
tetracyclic diterpenoid | antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| etoposide | | beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound | antineoplastic agent;
DNA synthesis inhibitor | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| substance p | | peptide | neurokinin-1 receptor agonist;
neurotransmitter;
vasodilator agent | 2000 | 2021 | 12.6 | low | 0 | 0 | 1 | 1 | 2 | 1 |
| pendimethalin | | C-nitro compound;
secondary amino compound;
substituted aniline | agrochemical;
environmental contaminant;
herbicide | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1-methyl-4-phenylpyridinium | | pyridinium ion | apoptosis inducer;
herbicide;
human xenobiotic metabolite;
neurotoxin | 2000 | 2023 | 12.2 | low | 0 | 0 | 1 | 27 | 31 | 6 |
| ng-nitroarginine methyl ester | | alpha-amino acid ester;
L-arginine derivative;
methyl ester;
N-nitro compound | EC 1.14.13.39 (nitric oxide synthase) inhibitor | 2002 | 2022 | 11.0 | low | 0 | 0 | 0 | 2 | 3 | 1 |
| permethrin | | cyclopropanecarboxylate ester;
cyclopropanes | agrochemical;
ectoparasiticide;
pyrethroid ester acaricide;
pyrethroid ester insecticide;
scabicide | 2003 | 2019 | 12.5 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| exifone | | benzophenones | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| chlorodiphenyl (54% chlorine) | | | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| quisqualic acid | | non-proteinogenic alpha-amino acid | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nitazoxanide | | benzamides;
carboxylic ester | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| captopril | | alkanethiol;
L-proline derivative;
N-acylpyrrolidine;
pyrrolidinemonocarboxylic acid | antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| fenpropathrin, (+-)-isomer | | aromatic ether;
cyclopropanecarboxylate ester | agrochemical;
pyrethroid ester acaricide;
pyrethroid ester insecticide | 2016 | 2020 | 6.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| pergolide | | diamine;
methyl sulfide;
organic heterotetracyclic compound | antiparkinson drug;
dopamine agonist | 2002 | 2008 | 18.3 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| colforsin | | acetate ester;
cyclic ketone;
labdane diterpenoid;
organic heterotricyclic compound;
tertiary alpha-hydroxy ketone;
triol | adenylate cyclase agonist;
anti-HIV agent;
antihypertensive agent;
plant metabolite;
platelet aggregation inhibitor;
protein kinase A agonist | 2001 | 2014 | 14.9 | low | 0 | 0 | 0 | 4 | 3 | 0 |
| triclabendazole | | aromatic ether | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| fomesafen | | aromatic ether;
C-nitro compound;
monochlorobenzenes;
N-sulfonylcarboxamide;
organofluorine compound;
phenols | agrochemical;
EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide | 2003 | 2016 | 14.0 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| miglustat | | piperidines;
tertiary amino compound | anti-HIV agent;
EC 2.4.1.80 (ceramide glucosyltransferase) inhibitor | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| lovastatin | | delta-lactone;
fatty acid ester;
hexahydronaphthalenes;
polyketide;
statin (naturally occurring) | anticholesteremic drug;
antineoplastic agent;
Aspergillus metabolite;
prodrug | 2004 | 2017 | 13.7 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| simvastatin | | delta-lactone;
fatty acid ester;
hexahydronaphthalenes;
statin (semi-synthetic) | EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor;
EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor;
ferroptosis inducer;
geroprotector;
prodrug | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| quinpirole | | pyrazoloquinoline | dopamine agonist | 2009 | 2019 | 8.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| pravastatin | | 3-hydroxy carboxylic acid;
carbobicyclic compound;
carboxylic ester;
hydroxy monocarboxylic acid;
secondary alcohol;
statin (semi-synthetic) | anticholesteremic drug;
environmental contaminant;
metabolite;
xenobiotic | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| cabergoline | | N-acylurea | antineoplastic agent;
antiparkinson drug;
dopamine agonist | 2009 | 2018 | 10.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| mifepristone | | 3-oxo-Delta(4) steroid;
acetylenic compound;
tertiary amino compound | abortifacient;
contraceptive drug;
hormone antagonist;
synthetic oral contraceptive | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| itraconazole | | aromatic ether;
conazole antifungal drug;
cyclic ketal;
dichlorobenzene;
dioxolane;
N-arylpiperazine;
triazole antifungal drug;
triazoles | EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor;
Hedgehog signaling pathway inhibitor;
P450 inhibitor | 2022 | 2022 | 2.0 | low | 1 | 0 | 0 | 0 | 0 | 1 |
| ractopamine | | benzyl alcohols;
polyphenol;
secondary alcohol;
secondary amino compound | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| fluorodopa f 18 | | (18)F radiopharmaceutical;
6-fluoro-L-dopa | | 2006 | 2012 | 14.0 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| fura-2 | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| imiquimod | | imidazoquinoline | antineoplastic agent;
interferon inducer | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| n 0437, (-)-isomer | | tetralins | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 3-iodobenzylguanidine | | organoiodine compound | | 2006 | 2022 | 8.2 | low | 0 | 0 | 0 | 3 | 3 | 3 |
| adenosine | | adenosines;
purines D-ribonucleoside | analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent | 2004 | 2014 | 14.8 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| safranal | | monoterpenoid | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 3-n-butylphthalide | | benzofurans | | 2010 | 2023 | 5.0 | low | 0 | 0 | 0 | 1 | 1 | 3 |
| coomassie brilliant blue r | | | | 2001 | 2018 | 14.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| vanadates | | trivalent inorganic anion;
vanadium oxoanion | EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ammonium peroxydisulfate | | | | 2012 | 2019 | 8.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| octyl glucoside | | beta-D-glucoside | plant metabolite | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| trazodone hydrochloride | | hydrochloride | adrenergic antagonist;
antidepressant;
H1-receptor antagonist;
sedative;
serotonin uptake inhibitor | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| glucose, (beta-d)-isomer | | D-glucopyranose | epitope;
mouse metabolite | 2011 | 2024 | 6.8 | low | 0 | 0 | 0 | 0 | 13 | 5 |
| mevastatin | | 2-pyranones;
carboxylic ester;
hexahydronaphthalenes;
polyketide;
statin (naturally occurring) | antifungal agent;
apoptosis inducer;
EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor;
fungal metabolite;
Penicillium metabolite | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ursolic acid | | hydroxy monocarboxylic acid;
pentacyclic triterpenoid | geroprotector;
plant metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| thiazolyl blue | | organic bromide salt | colorimetric reagent;
dye | 2000 | 2014 | 16.5 | low | 0 | 0 | 2 | 6 | 5 | 0 |
| baicalin | | dihydroxyflavone;
glucosiduronic acid;
glycosyloxyflavone;
monosaccharide derivative | antiatherosclerotic agent;
antibacterial agent;
anticoronaviral agent;
antineoplastic agent;
antioxidant;
cardioprotective agent;
EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
ferroptosis inhibitor;
neuroprotective agent;
non-steroidal anti-inflammatory drug;
plant metabolite;
prodrug | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 5-methylcytosine | | methylcytosine;
pyrimidines | human metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| epigallocatechin gallate | | flavans;
gallate ester;
polyphenol | antineoplastic agent;
antioxidant;
apoptosis inducer;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent;
plant metabolite | 2004 | 2023 | 8.1 | low | 0 | 0 | 0 | 8 | 27 | 7 |
| fluorexon | | xanthene dye | fluorochrome | 2013 | 2020 | 6.7 | low | 0 | 0 | 0 | 0 | 6 | 0 |
| gallocatechol | | gallocatechin | antioxidant;
metabolite;
radical scavenger | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| aica ribonucleotide | | 1-(phosphoribosyl)imidazolecarboxamide;
aminoimidazole | cardiovascular drug;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| salvin | | abietane diterpenoid;
carbotricyclic compound;
catechols;
monocarboxylic acid | angiogenesis modulating agent;
anti-inflammatory agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
food preservative;
HIV protease inhibitor;
plant metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| nile red | | aromatic amine;
cyclic ketone;
organic heterotetracyclic compound;
tertiary amino compound | fluorochrome;
histological dye | 2018 | 2019 | 5.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| tris(2,2'-bipyridine)ruthenium(II) | | ruthenium coordination entity | fluorochrome | 2006 | 2012 | 15.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| pyrrolidine dithiocarbamate | | dithiocarbamic acids;
pyrrolidines | anticonvulsant;
antineoplastic agent;
geroprotector;
neuroprotective agent;
NF-kappaB inhibitor;
radical scavenger | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| peroxynitric acid | | nitrogen oxoacid | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| glutathione disulfide | | glutathione derivative;
organic disulfide | Escherichia coli metabolite;
mouse metabolite | 2003 | 2014 | 15.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| telmisartan | | benzimidazoles;
biphenyls;
carboxybiphenyl | angiotensin receptor antagonist;
antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
environmental contaminant;
xenobiotic | 2013 | 2018 | 8.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| triazoles | | 1,2,3-triazole | | 2000 | 2022 | 8.2 | low | 0 | 0 | 1 | 0 | 1 | 2 |
| delphinidin | | anthocyanidin chloride | | 2022 | 2023 | 1.5 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| 1,2-dithiol-3-thione | | 1,2-dithiole | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| fluorodeoxyglucose f18 | | 2-deoxy-2-((18)F)fluoro-D-glucose;
2-deoxy-2-fluoro-aldehydo-D-glucose | | 2009 | 2022 | 8.5 | low | 1 | 0 | 0 | 1 | 5 | 2 |
| sertraline | | dichlorobenzene;
secondary amino compound;
tetralins | antidepressant;
serotonin uptake inhibitor | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| masoprocol | | nordihydroguaiaretic acid | antineoplastic agent;
hypoglycemic agent;
lipoxygenase inhibitor;
metabolite | 2012 | 2023 | 6.8 | low | 0 | 0 | 0 | 0 | 4 | 1 |
| trichlorosucrose | | disaccharide derivative;
organochlorine compound | environmental contaminant;
sweetening agent;
xenobiotic | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| hesperetin | | 3'-hydroxyflavanones;
4'-methoxyflavanones;
monomethoxyflavanone;
trihydroxyflavanone | antineoplastic agent;
antioxidant;
plant metabolite | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| honokiol | | biphenyls | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| lycorine | | indolizidine alkaloid | anticoronaviral agent;
antimalarial;
plant metabolite;
protein synthesis inhibitor | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| leupeptin | | aldehyde;
tripeptide | bacterial metabolite;
calpain inhibitor;
cathepsin B inhibitor;
EC 3.4.21.4 (trypsin) inhibitor;
serine protease inhibitor | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| squalamine | | bile acid | | 2017 | 2020 | 5.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| beta-amyrin | | pentacyclic triterpenoid;
secondary alcohol | Aspergillus metabolite;
plant metabolite | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| hederagenin | | dihydroxy monocarboxylic acid;
pentacyclic triterpenoid;
sapogenin | plant metabolite | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| bilobalide | | sesquiterpene lactone | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ceric oxide | | cerium molecular entity;
metal oxide | | 2018 | 2019 | 5.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| hydroxyindoleacetaldehyde | | hydroxyindoles;
indoleacetaldehyde | human metabolite;
mouse metabolite | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1-hydroxybenzotriazole | | benzotriazoles | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 2-aminoindan | | | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| rivastigmine | | carbamate ester;
tertiary amino compound | cholinergic drug;
EC 3.1.1.8 (cholinesterase) inhibitor;
neuroprotective agent | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| rosiglitazone | | aminopyridine;
thiazolidinediones | EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor;
ferroptosis inhibitor;
insulin-sensitizing drug | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| bexarotene | | benzoic acids;
naphthalenes;
retinoid | antineoplastic agent | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-phenyl-1,2,3,6-tetrahydropyridine | | | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 3,4-dihydroxyphenylethanol | | catechols;
primary alcohol | antineoplastic agent;
antioxidant;
metabolite | 2014 | 2023 | 4.0 | low | 0 | 0 | 0 | 0 | 5 | 4 |
| 4-phenylbutylamine | | benzenes;
phenylalkylamine;
primary amino compound | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| coenzyme a | | adenosine 3',5'-bisphosphate | coenzyme;
Escherichia coli metabolite;
mouse metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| nicotine | | 3-(1-methylpyrrolidin-2-yl)pyridine | anxiolytic drug;
biomarker;
immunomodulator;
mitogen;
neurotoxin;
nicotinic acetylcholine receptor agonist;
peripheral nervous system drug;
phytogenic insecticide;
plant metabolite;
psychotropic drug;
teratogenic agent;
xenobiotic | 2007 | 2023 | 7.3 | low | 0 | 0 | 0 | 2 | 7 | 2 |
| fibrinogen | | iditol | fungal metabolite | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| homocysteine | | amino acid zwitterion;
homocysteine;
serine family amino acid | fundamental metabolite;
mouse metabolite | 2005 | 2013 | 15.0 | low | 0 | 0 | 0 | 3 | 1 | 0 |
| salsolinol | | 1-methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol | human urinary metabolite | 2013 | 2020 | 7.5 | low | 0 | 0 | 0 | 0 | 4 | 0 |
| 1,5-i-aedans | | aminonaphthalenesulfonic acid | fluorescent probe | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pyridaben | | organochlorine acaricide;
organochlorine insecticide;
pyridazinone | mitochondrial NADH:ubiquinone reductase inhibitor | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3-fluorotyrosine | | fluoroamino acid;
fluorophenol;
non-proteinogenic alpha-amino acid;
tyrosine derivative | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| picein | | glycoside | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| melamine phosphate | | | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| firefly luciferin | | 1,3-thiazolemonocarboxylic acid;
benzothiazoles;
imidothioate | luciferin | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| glycidyl nitrate | | | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1-phenazinecarboxylic acid | | aromatic carboxylic acid;
monocarboxylic acid;
phenazines | antifungal agent;
antimicrobial agent;
bacterial metabolite | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline | | benzyltetrahydroisoquinoline | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| coumarin 6 | | 7-aminocoumarins | fluorochrome | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cobalt | | cobalt group element atom;
metal allergen | micronutrient | 2004 | 2022 | 9.4 | low | 0 | 0 | 0 | 2 | 2 | 1 |
| arginyl-glycyl-aspartic acid | | oligopeptide | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| vitamin b 6 | | | | 2009 | 2017 | 11.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| acrylodan | | | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| laurdan | | | | 2003 | 2015 | 15.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| cyanates | | | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| (3h)2-carbomethoxy-3-(4-fluorophenyl)tropane | | | | 2007 | 2009 | 16.3 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| epibatidine | | | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| beta-n-methylamino-l-alanine | | diamino acid;
L-alanine derivative;
non-proteinogenic L-alpha-amino acid;
secondary amino compound | bacterial metabolite;
neurotoxin | 2009 | 2015 | 12.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| 3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonate | | 1,1-diunsubstituted alkanesulfonate | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dimyristoylphosphatidylglycerol | | | | 2003 | 2019 | 11.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| geniposide | | terpene glycoside | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dityrosine | | biphenyls;
non-proteinogenic alpha-amino acid;
tyrosine derivative | biomarker | 2000 | 2022 | 11.5 | low | 0 | 0 | 1 | 4 | 4 | 2 |
| epicatechin gallate | | catechin;
gallate ester;
polyphenol | EC 3.2.1.1 (alpha-amylase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
metabolite | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| fingolimod hydrochloride | | hydrochloride | immunosuppressive agent;
prodrug;
sphingosine-1-phosphate receptor agonist | 2016 | 2021 | 5.4 | low | 0 | 0 | 0 | 0 | 6 | 1 |
| triptolide | | diterpenoid;
epoxide;
gamma-lactam;
organic heteroheptacyclic compound | antispermatogenic agent;
plant metabolite | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1-hexadecyl-2-acetyl-glycero-3-phosphocholine | | 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine | antihypertensive agent;
beta-adrenergic antagonist;
bronchoconstrictor agent;
hematologic agent;
vasodilator agent | 2008 | 2015 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| deoxyglucose | | | | 2008 | 2022 | 9.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| anserine | | beta-alanine derivative;
dipeptide;
zwitterion | animal metabolite;
mouse metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 5,6-dihydroxyindole | | dihydroxyindole | mouse metabolite | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1-phenyl-2-decanoylamino-3-morpholino-1-propanol | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tanshinone | | abietane diterpenoid | anticoronaviral agent | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1,2-dimyristoylphosphatidylethanolamine | | | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| gastrodin | | glycoside | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ponasterone a | | 14alpha-hydroxy steroid;
20-hydroxy steroid;
22-hydroxy steroid;
2beta-hydroxy steroid;
3beta-hydroxy steroid;
6-oxo steroid;
phytoecdysteroid | | 2000 | 2004 | 22.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| 3'-o-(4-benzoyl)benzoyladenosine 5'-triphosphate | | purine ribonucleoside triphosphate | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 3,5-dibromo-4-nitrosobenzenesulfonate | | | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ginkgolide a | | diterpene lactone | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| glyceraldehyde 3-phosphate dehydrogenase (304-313) | | | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 3,4-dihydroxyphenylacetaldehyde | | alpha-CH2-containing aldehyde;
catechols;
phenylacetaldehydes | Escherichia coli metabolite;
human metabolite;
mouse metabolite | 2006 | 2021 | 7.3 | medium | 0 | 0 | 0 | 1 | 16 | 2 |
| astilbin | | 3'-hydroxyflavanones;
4'-hydroxyflavanones;
alpha-L-rhamnoside;
flavanone glycoside;
monosaccharide derivative;
tetrahydroxyflavanone | anti-inflammatory agent;
plant metabolite;
radical scavenger | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| caprylates | | fatty acid anion 8:0;
straight-chain saturated fatty acid anion | human metabolite;
Saccharomyces cerevisiae metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tris(2-carboxyethyl)phosphine | | phosphine derivative;
tricarboxylic acid | reducing agent | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pramipexole | | benzothiazoles;
diamine | antidyskinesia agent;
antiparkinson drug;
dopamine agonist;
radical scavenger | 2001 | 2023 | 8.8 | low | 0 | 0 | 0 | 2 | 7 | 2 |
| calpain inhibitor 2 | | peptide | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 5-s-cysteinyldopamine | | S-conjugate | | 2014 | 2019 | 7.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| 5-fluorodopamine | | | | 2004 | 2012 | 16.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| astragaloside a | | | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| celastrol | | monocarboxylic acid;
pentacyclic triterpenoid | anti-inflammatory drug;
antineoplastic agent;
antioxidant;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
Hsp90 inhibitor;
metabolite | 2022 | 2023 | 1.5 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| peroxynitrous acid | | nitrogen oxoacid | | 2001 | 2016 | 16.7 | low | 0 | 0 | 0 | 7 | 4 | 0 |
| 1-aminoindan | | | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| fullerene c60 | | fullerene | geroprotector | 2019 | 2020 | 4.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| imatinib mesylate | | methanesulfonate salt | anticoronaviral agent;
antineoplastic agent;
apoptosis inducer;
tyrosine kinase inhibitor | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dimyristoylphosphatidylserine | | | | 2016 | 2020 | 6.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| n(6)-carboxymethyllysine | | L-lysine derivative;
non-proteinogenic L-alpha-amino acid | antigen | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ro 8-0576 | | | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| angiotensin ii, des-asp(1)-des-arg(2)-ile(5)- | | organic molecular entity | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dihydrotetrabenazine | | isoquinolines | | 2012 | 2017 | 9.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| 1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone | | dichlorobenzene;
differentiation-inducing factor;
monomethoxybenzene;
resorcinols | eukaryotic metabolite;
signalling molecule | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 27-hydroxycholesterol | | 26-hydroxycholesterol | apoptosis inducer;
human metabolite;
mouse metabolite;
neuroprotective agent | 2008 | 2023 | 10.2 | low | 0 | 0 | 0 | 2 | 3 | 1 |
| skullcapflavone ii | | dihydroxyflavone;
tetramethoxyflavone | anti-asthmatic drug;
plant metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| glycerophosphoinositol 4,5-bisphosphate | | | | 2005 | 2023 | 6.9 | low | 0 | 0 | 0 | 2 | 2 | 3 |
| indatraline | | indanes | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| dihydroethidium | | | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| delphinidin | | 5-hydroxyanthocyanidin | antineoplastic agent;
biological pigment;
plant metabolite | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| n-isobutyrylcysteine | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| l 690330 | | 1,1-bis(phosphonic acid) | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| lanthionine ketimine | | 1,4-thiazine;
dicarboxylic acid;
sulfur-containing amino acid | anti-inflammatory agent;
human urinary metabolite;
neuroprotective agent | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| pomalidomide | | aromatic amine;
dicarboximide;
isoindoles;
piperidones | angiogenesis inhibitor;
antineoplastic agent;
immunomodulator | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| proline | | amino acid zwitterion;
glutamine family amino acid;
L-alpha-amino acid;
proline;
proteinogenic amino acid | algal metabolite;
compatible osmolytes;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite | 1998 | 2020 | 13.2 | low | 0 | 0 | 3 | 16 | 20 | 0 |
| 6-hydroxybenzothiazole | | | | 2022 | 2022 | 2.0 | medium | 0 | 0 | 0 | 0 | 0 | 1 |
| mn(iii) 5,10,15,20-tetrakis(n-methylpyridinium-2-yl)porphyrin | | | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| kolaviron | | 4'-methoxyflavanones;
biflavonoid;
dihydroflavonols;
ring assembly;
secondary alpha-hydroxy ketone | hepatoprotective agent;
plant metabolite | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ym 09151-2 | | N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| hydroxyl radical | | oxygen hydride;
oxygen radical;
reactive oxygen species | | 2002 | 2012 | 18.9 | low | 0 | 0 | 0 | 6 | 1 | 0 |
| rhodioloside | | glycoside | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| singlet oxygen | | chalcogen;
monoatomic oxygen;
nonmetal atom | macronutrient | 2016 | 2020 | 6.3 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| ampelopsin | | dihydromyricetin;
secondary alpha-hydroxy ketone | antineoplastic agent;
antioxidant;
metabolite | 2016 | 2020 | 5.7 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| 8-aminohexylamino camp | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dopamine quinone | | 1,2-benzoquinones;
primary amino compound | metabolite | 2005 | 2023 | 9.8 | medium | 0 | 0 | 0 | 3 | 2 | 1 |
| hydromethylthionine | | aromatic amine;
phenothiazines;
tertiary amino compound | bacterial xenobiotic metabolite;
fluorochrome;
mouse metabolite;
rat metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| thiophosphoric acid | | phosphorothioic acid | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| peiminine | | alkaloid | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| aminochrome 1 | | indoledione;
orthoquinones | neurotoxin | 2005 | 2022 | 10.0 | low | 0 | 0 | 0 | 2 | 2 | 1 |
| biotin | | biotins;
vitamin B7 | coenzyme;
cofactor;
Escherichia coli metabolite;
fundamental metabolite;
human metabolite;
mouse metabolite;
nutraceutical;
prosthetic group;
Saccharomyces cerevisiae metabolite | 1997 | 2023 | 14.5 | low | 0 | 0 | 1 | 1 | 1 | 1 |
| angiotensin ii | | amino acid zwitterion;
angiotensin II | human metabolite | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3-n-butyl-4,5-dihydrophthalide | | | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sb 203580 | | imidazoles;
monofluorobenzenes;
pyridines;
sulfoxide | EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent | 2002 | 2020 | 12.2 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| sb 216763 | | indoles;
maleimides | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| acetylcorynoline | | benzophenanthridine alkaloid | | 2014 | 2014 | 10.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| gvs 111 | | | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| scutellarin | | glucosiduronic acid;
glycosyloxyflavone;
monosaccharide derivative;
trihydroxyflavone | antineoplastic agent;
proteasome inhibitor | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| aspartimide | | dicarboximide;
primary amino compound;
pyrrolidinone | Maillard reaction product | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| phenserine | | | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| g(m1)-oligosaccharide | | beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc | epitope | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| latrepirdine | | methylpyridines;
pyridoindole | geroprotector | 2011 | 2013 | 11.5 | low | 0 | 0 | 0 | 0 | 4 | 0 |
| anabasine | | anabasine | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| deferasirox | | benzoic acids;
monocarboxylic acid;
phenols;
triazoles | iron chelator | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dabigatran | | aromatic amide;
benzimidazoles;
beta-alanine derivative;
carboxamidine;
pyridines | anticoagulant;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
EC 3.4.21.5 (thrombin) inhibitor | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| lenalidomide | | aromatic amine;
dicarboximide;
isoindoles;
piperidones | angiogenesis inhibitor;
antineoplastic agent;
immunomodulator | 2015 | 2017 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| brazilin | | 1-benzopyran | | 2019 | 2021 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| 3-nitrotyrosine | | 2-nitrophenols;
C-nitro compound;
nitrotyrosine;
non-proteinogenic alpha-amino acid | | 2000 | 2021 | 15.0 | low | 0 | 0 | 2 | 16 | 10 | 1 |
| anisomycin | | monohydroxypyrrolidine;
organonitrogen heterocyclic antibiotic | anticoronaviral agent;
antimicrobial agent;
antineoplastic agent;
antiparasitic agent;
bacterial metabolite;
DNA synthesis inhibitor;
protein synthesis inhibitor | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| benzofurans | | | | 2010 | 2021 | 7.0 | low | 0 | 0 | 0 | 1 | 5 | 1 |
| withaferin a | | 27-hydroxy steroid;
4-hydroxy steroid;
delta-lactone;
enone;
epoxy steroid;
ergostanoid;
primary alcohol;
secondary alcohol;
withanolide | antineoplastic agent;
apoptosis inducer | 2024 | 2024 | 0.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| fusicoccin | | | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| noscapine | | aromatic ether;
benzylisoquinoline alkaloid;
cyclic acetal;
isobenzofuranone;
organic heterobicyclic compound;
organic heterotricyclic compound;
tertiary amino compound | antineoplastic agent;
antitussive;
apoptosis inducer;
plant metabolite | 2012 | 2021 | 6.3 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| withanolides | | | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| gitoxigenin | | 14beta-hydroxy steroid;
16beta-hydroxy steroid;
3beta-hydroxy steroid | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| taurochenodeoxycholic acid | | bile acid taurine conjugate | human metabolite;
mouse metabolite | 2005 | 2020 | 10.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| bortezomib | | amino acid amide;
L-phenylalanine derivative;
pyrazines | antineoplastic agent;
antiprotozoal drug;
protease inhibitor;
proteasome inhibitor | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dihydropyridines | | | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 4-aminopiperidine | | | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| leupeptins | | | | 2001 | 2015 | 16.4 | low | 0 | 0 | 0 | 11 | 3 | 0 |
| lithium chloride | | inorganic chloride;
lithium salt | antimanic drug;
geroprotector | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| s-adenosylhomocysteine | | adenosines;
amino acid zwitterion;
homocysteine derivative;
homocysteines;
organic sulfide | cofactor;
EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor;
EC 2.1.1.79 (cyclopropane-fatty-acyl-phospholipid synthase) inhibitor;
epitope;
fundamental metabolite | 2009 | 2013 | 13.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| glyceraldehyde 3-phosphate | | glyceraldehyde 3-phosphate | mouse metabolite | 2008 | 2019 | 8.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| arabinose | | L-arabinose | Escherichia coli metabolite;
mouse metabolite | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| glucosamine | | D-glucosamine | Escherichia coli metabolite;
geroprotector;
mouse metabolite | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| carnosine | | amino acid zwitterion;
dipeptide | anticonvulsant;
antineoplastic agent;
antioxidant;
Daphnia magna metabolite;
geroprotector;
human metabolite;
mouse metabolite;
neuroprotective agent | 2003 | 2021 | 8.8 | low | 0 | 0 | 0 | 1 | 2 | 1 |
| mevalonic acid | | 3,5-dihydroxy-3-methylpentanoic acid | | 2004 | 2009 | 17.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| naringenin | | (2S)-flavan-4-one;
naringenin | expectorant;
plant metabolite | 2018 | 2023 | 3.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| nitroarginine | | guanidines;
L-arginine derivative;
N-nitro compound;
non-proteinogenic L-alpha-amino acid | | 2006 | 2020 | 9.8 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| ginsenoside rg1 | | 12beta-hydroxy steroid;
3beta-hydroxy-4,4-dimethylsteroid;
beta-D-glucoside;
ginsenoside;
tetracyclic triterpenoid | neuroprotective agent;
pro-angiogenic agent | 2015 | 2016 | 8.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| beta-hederin | | triterpenoid | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| genipin | | iridoid monoterpenoid | anti-inflammatory agent;
antioxidant;
apoptosis inhibitor;
cross-linking reagent;
hepatotoxic agent;
uncoupling protein inhibitor | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| swertiamarin | | glycoside | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| ochratoxin a | | isochromanes;
monocarboxylic acid amide;
N-acyl-L-phenylalanine;
organochlorine compound;
phenylalanine derivative | Aspergillus metabolite;
calcium channel blocker;
carcinogenic agent;
mycotoxin;
nephrotoxin;
Penicillium metabolite;
teratogenic agent | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| lignans | | | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| acetylleucyl-leucyl-norleucinal | | aldehyde;
tripeptide | cysteine protease inhibitor | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sodium arsenite | | arsenic molecular entity;
inorganic sodium salt | antibacterial agent;
antifungal agent;
antineoplastic agent;
carcinogenic agent;
herbicide;
insecticide;
rodenticide | 2007 | 2015 | 13.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| vinpocetine | | alkaloid | geroprotector | 2017 | 2023 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| betadex | | cyclodextrin | | 2004 | 2022 | 11.1 | low | 0 | 0 | 0 | 2 | 4 | 1 |
| maleic acid | | butenedioic acid | algal metabolite;
mouse metabolite;
plant metabolite | 2020 | 2021 | 3.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| e-z cinnamic acid | | cinnamic acid | plant metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ergosterol | | 3beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
ergostanoid;
phytosterols | fungal metabolite;
Saccharomyces cerevisiae metabolite | 2008 | 2009 | 15.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| trichostatin a | | antibiotic antifungal agent;
hydroxamic acid;
trichostatin | bacterial metabolite;
EC 3.5.1.98 (histone deacetylase) inhibitor;
geroprotector | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tretinoin | | retinoic acid;
vitamin A | anti-inflammatory agent;
antineoplastic agent;
antioxidant;
AP-1 antagonist;
human metabolite;
keratolytic drug;
retinoic acid receptor agonist;
retinoid X receptor agonist;
signalling molecule | 2006 | 2023 | 9.5 | low | 0 | 0 | 0 | 3 | 6 | 1 |
| arachidonic acid | | icosa-5,8,11,14-tetraenoic acid;
long-chain fatty acid;
omega-6 fatty acid | Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite;
mouse metabolite | 2005 | 2022 | 10.2 | low | 0 | 0 | 0 | 4 | 5 | 1 |
| resveratrol | | resveratrol | antioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger | 2007 | 2022 | 8.7 | low | 0 | 0 | 0 | 2 | 6 | 2 |
| retinol | | retinol;
vitamin A | human metabolite;
mouse metabolite;
plant metabolite | 2007 | 2021 | 11.1 | low | 0 | 0 | 0 | 3 | 5 | 1 |
| latrunculin a | | cyclic hemiketal;
macrolide;
oxabicycloalkane;
thiazolidinone | actin polymerisation inhibitor;
metabolite;
toxin | 2008 | 2012 | 14.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| cyanoginosin lr | | microcystin | bacterial metabolite;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
environmental contaminant;
xenobiotic | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| oleic acid | | octadec-9-enoic acid | antioxidant;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite;
solvent | 2001 | 2019 | 12.6 | low | 0 | 0 | 0 | 2 | 3 | 0 |
| tacrolimus | | macrolide lactam | bacterial metabolite;
immunosuppressive agent | 2001 | 2017 | 12.9 | low | 0 | 0 | 0 | 4 | 6 | 0 |
| ferulic acid | | ferulic acids | anti-inflammatory agent;
antioxidant;
apoptosis inhibitor;
cardioprotective agent;
MALDI matrix material;
plant metabolite | 2015 | 2022 | 5.3 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| cocaine | | benzoate ester;
methyl ester;
tertiary amino compound;
tropane alkaloid | adrenergic uptake inhibitor;
central nervous system stimulant;
dopamine uptake inhibitor;
environmental contaminant;
local anaesthetic;
mouse metabolite;
plant metabolite;
serotonin uptake inhibitor;
sodium channel blocker;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic | 2003 | 2022 | 12.8 | low | 0 | 0 | 0 | 7 | 5 | 1 |
| thapsigargin | | butyrate ester;
organic heterotricyclic compound;
sesquiterpene lactone | calcium channel blocker;
EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor | 2004 | 2018 | 13.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| isofagomine | | piperidines | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| desoxyepothilone b | | epothilone | microtubule-stabilising agent | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| stigmatellin | | aromatic ether;
chromones;
olefinic compound;
phenols | bacterial metabolite;
quinol oxidation site inhibitor | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| t0901317 | | | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| y 27632 | | aromatic amide | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| prostaglandin d2 | | prostaglandins D | human metabolite;
mouse metabolite | 2006 | 2009 | 16.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| epothilone a | | epothilone;
epoxide | antineoplastic agent;
metabolite;
microtubule-stabilising agent;
tubulin modulator | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 6-bromoindirubin-3'-oxime | | | | 2017 | 2021 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| roflumilast | | aromatic ether;
benzamides;
chloropyridine;
cyclopropanes;
organofluorine compound | anti-asthmatic drug;
phosphodiesterase IV inhibitor | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| decitabine | | 2'-deoxyribonucleoside | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| texas red | | organic heteroheptacyclic compound | fluorochrome | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| iridoids | | | | 2016 | 2023 | 4.7 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| dactinomycin | | actinomycin | mutagen | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| benzyloxycarbonylleucyl-leucyl-leucine aldehyde | | amino aldehyde;
carbamate ester;
tripeptide | proteasome inhibitor | 2002 | 2015 | 15.7 | low | 0 | 0 | 0 | 9 | 3 | 0 |
| reynosin | | organic heterotricyclic compound;
sesquiterpene lactone | metabolite | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| riboflavin | | flavin;
vitamin B2 | anti-inflammatory agent;
antioxidant;
cofactor;
Escherichia coli metabolite;
food colouring;
fundamental metabolite;
human urinary metabolite;
mouse metabolite;
photosensitizing agent;
plant metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| amiridine | | aminoquinoline | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| carbenoxolone sodium | | triterpenoid | | 2013 | 2014 | 10.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| alpha-asarone | | asarone | anticonvulsant;
GABA modulator | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| anethole | | anethole | flavouring agent | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| geraniol | | 3,7-dimethylocta-2,6-dien-1-ol;
monoterpenoid;
primary alcohol | allergen;
fragrance;
plant metabolite;
volatile oil component | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| glycosides | | | | 2020 | 2021 | 3.2 | low | 0 | 0 | 0 | 0 | 1 | 3 |
| chalcone | | chalcone | EC 3.2.1.1 (alpha-amylase) inhibitor | 2018 | 2022 | 3.3 | low | 0 | 0 | 0 | 0 | 1 | 2 |
| isomethyleugenol | | isomethyleugenol | | 2008 | 2022 | 8.6 | low | 0 | 0 | 0 | 2 | 8 | 1 |
| piperine | | benzodioxoles;
N-acylpiperidine;
piperidine alkaloid;
tertiary carboxamide | food component;
human blood serum metabolite;
NF-kappaB inhibitor;
plant metabolite | 2016 | 2022 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| squalene | | triterpene | human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| stilbenes | | stilbene | | 2007 | 2016 | 10.9 | low | 0 | 0 | 0 | 2 | 9 | 0 |
| phenyl-n-tert-butylnitrone | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cannabidiol | | olefinic compound;
phytocannabinoid;
resorcinols | antimicrobial agent;
plant metabolite | 2022 | 2023 | 1.5 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| arginine vasopressin | | vasopressin | cardiovascular drug;
hematologic agent;
mitogen | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| s 1033 | | (trifluoromethyl)benzenes;
imidazoles;
pyridines;
pyrimidines;
secondary amino compound;
secondary carboxamide | anticoronaviral agent;
antineoplastic agent;
tyrosine kinase inhibitor | 2013 | 2020 | 5.8 | low | 1 | 0 | 0 | 0 | 6 | 0 |
| dodecylphosphocholine | | phosphocholines | detergent | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| isopropyl thiogalactoside | | S-glycosyl compound | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nsc 4347 | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sesquiterpenes | | | | 2013 | 2022 | 6.3 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| 3,3',4,5'-tetrahydroxystilbene | | catechols;
polyphenol;
resorcinols;
stilbenol | antineoplastic agent;
apoptosis inducer;
geroprotector;
hypoglycemic agent;
plant metabolite;
protein kinase inhibitor;
tyrosine kinase inhibitor | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| caffeic acid | | caffeic acid | geroprotector;
mouse metabolite | 2015 | 2019 | 7.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| cotinine | | N-alkylpyrrolidine;
pyridines;
pyrrolidin-2-ones;
pyrrolidine alkaloid | antidepressant;
biomarker;
human xenobiotic metabolite;
plant metabolite | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dieldrin | | epoxide;
organochlorine compound;
organochlorine insecticide | carcinogenic agent;
xenobiotic | 2001 | 2023 | 9.4 | low | 0 | 0 | 0 | 2 | 1 | 2 |
| curcumin | | aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol | anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger | 2008 | 2023 | 7.8 | low | 0 | 0 | 0 | 4 | 22 | 7 |
| curcumin | | aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol | anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger | 2008 | 2023 | 7.7 | low | 0 | 0 | 0 | 4 | 22 | 8 |
| benztropine | | diarylmethane | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 3-(1-azepanylsulfonyl)-n-(3-bromphenyl)benzamide | | | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| capsaicin | | capsaicinoid | non-narcotic analgesic;
TRPV1 agonist;
voltage-gated sodium channel blocker | 2018 | 2022 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| n-(4-(n-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide | | pyrazines;
sulfonamide;
thiophenes | necroptosis inhibitor;
neuroprotective agent | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| chlorogenic acid | | cinnamate ester;
tannin | food component;
plant metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| thiourea | | one-carbon compound;
thioureas;
ureas | antioxidant;
chromophore | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| fumonisin b1 | | diester;
fumonisin;
primary amino compound;
triol | carcinogenic agent;
metabolite | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tamoxifen | | stilbenoid;
tertiary amino compound | angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole | | | | 2007 | 2018 | 11.7 | low | 0 | 0 | 0 | 4 | 3 | 0 |
| rhyncophylline | | | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| u 0126 | | aryl sulfide;
dinitrile;
enamine;
substituted aniline | antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
osteogenesis regulator;
vasoconstrictor agent | 2001 | 2010 | 18.0 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| 6-methyl-2-(phenylethynyl)pyridine | | acetylenic compound;
methylpyridines | anxiolytic drug;
metabotropic glutamate receptor antagonist | 2010 | 2017 | 10.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| lithium | | alkali metal atom | | 2005 | 2019 | 9.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| cobaltous chloride | | cobalt salt;
inorganic chloride | allergen;
calcium channel blocker;
sensitiser;
two-colour indicator | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nitrogen dioxide | | nitrogen oxide | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| maneb | | | | 2007 | 2023 | 9.4 | low | 0 | 0 | 0 | 3 | 8 | 3 |
| raclopride | | salicylamides | | 2006 | 2009 | 17.0 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| 1,2-bis(2-aminophenoxy)ethane n,n,n',n'-tetraacetic acid acetoxymethyl ester | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cystine | | | | 2011 | 2019 | 8.0 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| sch 23390 | | benzazepine | | 2012 | 2018 | 9.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| rasagiline | | indanes;
secondary amine;
terminal acetylenic compound | EC 1.4.3.4 (monoamine oxidase) inhibitor;
neuroprotective agent | 2008 | 2022 | 7.4 | low | 0 | 0 | 0 | 2 | 6 | 2 |
| cytellin | | | | 2014 | 2020 | 7.7 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| silicon nitride | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 3-aminotyrosine | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ginsenosides | | | | 2013 | 2021 | 7.2 | low | 0 | 0 | 0 | 0 | 4 | 1 |
| cambinol | | | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| ovalbumin | | | | 2001 | 2012 | 17.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| 4-aminopyrrolidine-2,4-dicarboxylic acid | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-mercaptobenzeneacetic acid | | | | 2013 | 2013 | 11.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| sodium dodecyl sulfate | | organic sodium salt | detergent;
protein denaturant | 1999 | 2021 | 14.8 | low | 0 | 0 | 1 | 26 | 12 | 1 |
| crocin | | | | 2018 | 2022 | 4.0 | low | 0 | 0 | 0 | 0 | 2 | 2 |
| mtt formazan | | | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 6-cyano-7-nitroquinoxaline-2,3-dione | | quinoxaline derivative | | 2010 | 2017 | 11.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3h)-quinazolinone | | | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| alpha-chymotrypsin | | | | 2004 | 2023 | 14.0 | low | 0 | 0 | 0 | 3 | 1 | 1 |
| ferrostatin-1 | | ethyl ester;
primary arylamine;
substituted aniline | antifungal agent;
antioxidant;
ferroptosis inhibitor;
neuroprotective agent;
radiation protective agent;
radical scavenger | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| naphthoquinones | | | | 2012 | 2023 | 7.0 | low | 0 | 0 | 0 | 0 | 3 | 1 |
| tolcapone | | 2-nitrophenols;
benzophenones;
catechols | antiparkinson drug;
EC 2.1.1.6 (catechol O-methyltransferase) inhibitor | 2010 | 2020 | 7.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| myelin basic protein | | | | 2006 | 2020 | 11.8 | low | 0 | 0 | 0 | 5 | 7 | 0 |
| jnj 7777120 | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| methanethiosulfonate | | | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| diethyl maleate | | ethyl ester;
maleate ester | glutathione depleting agent | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sphingosine | | sphing-4-enine | human metabolite;
mouse metabolite | 2014 | 2021 | 6.7 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| quercetin | | 7-hydroxyflavonol;
pentahydroxyflavone | antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger | 2013 | 2023 | 4.9 | low | 0 | 0 | 0 | 0 | 4 | 3 |
| dinoprostone | | prostaglandins E | human metabolite;
mouse metabolite;
oxytocic | 2004 | 2007 | 18.7 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| dinoprost | | monocarboxylic acid;
prostaglandins Falpha | human metabolite;
mouse metabolite | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| apigenin | | trihydroxyflavone | antineoplastic agent;
metabolite | 2011 | 2020 | 8.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| luteolin | | 3'-hydroxyflavonoid;
tetrahydroxyflavone | angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 7,3'-dihydroxy-4'-methoxyisoflavone | | 4'-methoxyisoflavones;
7-hydroxyisoflavones | antioxidant;
metabolite | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| linoleic acid | | octadecadienoic acid;
omega-6 fatty acid | algal metabolite;
Daphnia galeata metabolite;
plant metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| calcitriol | | D3 vitamins;
hydroxycalciol;
triol | antineoplastic agent;
antipsoriatic;
bone density conservation agent;
calcium channel agonist;
calcium channel modulator;
hormone;
human metabolite;
immunomodulator;
metabolite;
mouse metabolite;
nutraceutical | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| psychosine | | glycosylsphingoid | human metabolite | 2011 | 2022 | 8.1 | low | 0 | 0 | 0 | 0 | 7 | 1 |
| scopoletin | | hydroxycoumarin | plant growth regulator;
plant metabolite | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| vitamin k semiquinone radical | | | | 2000 | 2013 | 17.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| beta carotene | | carotenoid beta-end derivative;
cyclic carotene | antioxidant;
biological pigment;
cofactor;
ferroptosis inhibitor;
human metabolite;
mouse metabolite;
plant metabolite;
provitamin A | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| retinol palmitate | | all-trans-retinyl ester;
retinyl palmitate | antioxidant;
Escherichia coli metabolite;
human xenobiotic metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| gossypetin | | 7-hydroxyflavonol;
hexahydroxyflavone | plant metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cholecalciferol | | D3 vitamins;
hydroxy seco-steroid;
seco-cholestane;
secondary alcohol;
steroid hormone | geroprotector;
human metabolite | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| rutin | | disaccharide derivative;
quercetin O-glucoside;
rutinoside;
tetrahydroxyflavone | antioxidant;
metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| kaempferol | | 7-hydroxyflavonol;
flavonols;
tetrahydroxyflavone | antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite | 2020 | 2021 | 3.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| 9-deoxy-delta-9-prostaglandin d2 | | prostaglandins J | human metabolite | 2006 | 2009 | 16.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| alpha-linolenic acid | | linolenic acid;
omega-3 fatty acid | micronutrient;
mouse metabolite;
nutraceutical | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| harmine | | harmala alkaloid | anti-HIV agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
metabolite | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| genistein | | 7-hydroxyisoflavones | antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| amphotericin b | | antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic | antiamoebic agent;
antiprotozoal drug;
bacterial metabolite | 2008 | 2017 | 11.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| montelukast | | aliphatic sulfide;
monocarboxylic acid;
quinolines | anti-arrhythmia drug;
anti-asthmatic drug;
leukotriene antagonist | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| entacapone | | 2-nitrophenols;
catechols;
monocarboxylic acid amide;
nitrile | antidyskinesia agent;
antiparkinson drug;
central nervous system drug;
EC 2.1.1.6 (catechol O-methyltransferase) inhibitor | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| astaxanthine | | carotenol;
carotenone | animal metabolite;
anticoagulant;
antioxidant;
food colouring;
plant metabolite | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| oleuropein | | beta-D-glucoside;
catechols;
diester;
methyl ester;
pyrans;
secoiridoid glycoside | anti-inflammatory agent;
antihypertensive agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
NF-kappaB inhibitor;
nutraceutical;
plant metabolite;
radical scavenger | 2019 | 2023 | 3.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| baicalein | | trihydroxyflavone | angiogenesis inhibitor;
anti-inflammatory agent;
antibacterial agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
EC 4.1.1.17 (ornithine decarboxylase) inhibitor;
ferroptosis inhibitor;
geroprotector;
hormone antagonist;
plant metabolite;
prostaglandin antagonist;
radical scavenger | 2004 | 2023 | 11.7 | low | 0 | 0 | 0 | 9 | 8 | 2 |
| chrysin | | 7-hydroxyflavonol;
dihydroxyflavone | anti-inflammatory agent;
antineoplastic agent;
antioxidant;
EC 2.7.11.18 (myosin-light-chain kinase) inhibitor;
hepatoprotective agent;
plant metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| diosmin | | dihydroxyflavanone;
disaccharide derivative;
glycosyloxyflavone;
monomethoxyflavone;
rutinoside | anti-inflammatory agent;
antioxidant | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| fisetin | | 3'-hydroxyflavonoid;
7-hydroxyflavonol;
tetrahydroxyflavone | anti-inflammatory agent;
antioxidant;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
metabolite;
plant metabolite | 2012 | 2021 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 2 |
| mangostin | | aromatic ether;
phenols;
xanthones | antimicrobial agent;
antineoplastic agent;
antioxidant;
plant metabolite | 2016 | 2022 | 4.8 | low | 0 | 0 | 0 | 0 | 2 | 2 |
| myricetin | | 7-hydroxyflavonol;
hexahydroxyflavone | antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite | 2015 | 2022 | 5.3 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| scutellarein | | tetrahydroxyflavone | metabolite | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| daidzein | | 7-hydroxyisoflavones | antineoplastic agent;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
phytoestrogen;
plant metabolite | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| rosmarinic acid | | rosmarinic acid | geroprotector;
plant metabolite | 2015 | 2023 | 4.4 | low | 0 | 0 | 0 | 0 | 3 | 2 |
| acteoside | | catechols;
cinnamate ester;
disaccharide derivative;
glycoside;
polyphenol | anti-inflammatory agent;
antibacterial agent;
antileishmanial agent;
neuroprotective agent;
plant metabolite | 2016 | 2021 | 5.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| tectorigenin | | 7-hydroxyisoflavones;
methoxyisoflavone | anti-inflammatory agent;
plant metabolite | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| wedelolactone | | aromatic ether;
coumestans;
delta-lactone;
polyphenol | antineoplastic agent;
apoptosis inducer;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
hepatoprotective agent;
metabolite | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| ellagic acid | | catechols;
cyclic ketone;
lactone;
organic heterotetracyclic compound;
polyphenol | antioxidant;
EC 1.14.18.1 (tyrosinase) inhibitor;
EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitor;
EC 2.4.1.1 (glycogen phosphorylase) inhibitor;
EC 2.5.1.18 (glutathione transferase) inhibitor;
EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor;
EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor;
EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
food additive;
fungal metabolite;
geroprotector;
plant metabolite;
skin lightening agent | 2014 | 2023 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 4 |
| ginkgolic acid | | hydroxybenzoic acid | | 2017 | 2019 | 6.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| coenzyme q10 | | ubiquinones | antioxidant;
ferroptosis inhibitor;
human metabolite | 2004 | 2019 | 13.5 | low | 0 | 0 | 0 | 6 | 5 | 0 |
| 1-palmitoyl-2-oleoylphosphatidylethanolamine | | (18R,21S)-24-amino-21-hydroxy-21-oxido-15-oxo-16,20,22-trioxa-21lambdalambda(5)-phosphatetracosan-18-yl icosanoate;
phosphatidylethanolamine | | 1998 | 2015 | 19.3 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| 1-palmitoyl-2-oleoylglycero-3-phosphoglycerol | | phosphatidylglycerol | | 2006 | 2021 | 10.2 | low | 0 | 0 | 0 | 3 | 7 | 2 |
| 4-hydroxy-2-nonenal | | 4-hydroxynon-2-enal;
4-hydroxynonenal | | 2001 | 2021 | 11.8 | low | 0 | 0 | 0 | 6 | 10 | 1 |
| 1-palmitoyl-2-oleoylglycero-3-phosphoserine | | 3-sn-phosphatidyl-L-serine | | 2008 | 2021 | 8.4 | low | 0 | 0 | 0 | 1 | 6 | 1 |
| menaquinone 6 | | | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sphingosine 1-phosphate | | sphingoid 1-phosphate | mouse metabolite;
signalling molecule;
sphingosine-1-phosphate receptor agonist;
T-cell proliferation inhibitor;
vasodilator agent | 2014 | 2021 | 6.7 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| diminazene aceturate | | N-acetylglycinate salt | antiparasitic agent;
trypanocidal drug | 2010 | 2019 | 9.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| vitamin k 1 | | phylloquinones;
vitamin K | cofactor;
human metabolite;
plant metabolite | 2013 | 2019 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| sirolimus | | antibiotic antifungal drug;
cyclic acetal;
cyclic ketone;
ether;
macrolide lactam;
organic heterotricyclic compound;
secondary alcohol | antibacterial drug;
anticoronaviral agent;
antineoplastic agent;
bacterial metabolite;
geroprotector;
immunosuppressive agent;
mTOR inhibitor | 2003 | 2022 | 9.2 | low | 1 | 0 | 0 | 3 | 11 | 3 |
| brefeldin a | | macrolide antibiotic | Penicillium metabolite | 2010 | 2020 | 9.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| morphine | | morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound | anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pd 180970 | | | | 2019 | 2020 | 4.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| lysophosphatidylcholines | | 1-O-acyl-sn-glycero-3-phosphocholine | | 2017 | 2023 | 3.8 | low | 0 | 0 | 0 | 0 | 2 | 2 |
| cytochalasin b | | cytochalasin;
lactam;
lactone;
organic heterotricyclic compound | actin polymerisation inhibitor;
metabolite;
mycotoxin;
platelet aggregation inhibitor | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pd 123319 | | imidazopyridine | angiotensin receptor antagonist;
endothelin receptor antagonist;
vasoconstrictor agent | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1,2-oleoylphosphatidylcholine | | phosphatidylcholine(1+) | | 2007 | 2022 | 8.3 | low | 0 | 0 | 0 | 3 | 5 | 3 |
| syringin | | beta-D-glucoside;
dimethoxybenzene;
monosaccharide derivative;
primary alcohol | hepatoprotective agent;
plant metabolite | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| kaempferol-3-o-rutinoside | | disaccharide derivative;
kaempferol O-glucoside;
rutinoside;
trihydroxyflavone | metabolite;
plant metabolite;
radical scavenger | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| icariin | | flavonols;
glycosyloxyflavone | antioxidant;
bone density conservation agent;
EC 3.1.4.35 (3',5'-cyclic-GMP phosphodiesterase) inhibitor;
phytoestrogen | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| squamosamide | | | | 2007 | 2017 | 11.5 | medium | 0 | 0 | 0 | 1 | 3 | 0 |
| casein kinase ii | | | | 2000 | 2022 | 12.3 | low | 0 | 0 | 1 | 9 | 9 | 3 |
| lead | | carbon group element atom;
elemental lead;
metal atom | neurotoxin | 2005 | 2023 | 10.3 | low | 0 | 0 | 0 | 3 | 4 | 2 |
| butylidenephthalide | | isobenzofuranone | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 6,7-dihydroxyflavone | | | | 2016 | 2022 | 4.7 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine | | cyanine dye;
indolium ion | fluorochrome | 2005 | 2009 | 17.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| diamide | | 1,1'-azobis(N,N-dimethylformamide) | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| methyl-3-methoxy-4-hydroxystyryl ketone | | hydroxycinnamic acid | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| aluminum | | boron group element atom;
elemental aluminium;
metal atom | | 2008 | 2021 | 9.0 | low | 0 | 0 | 0 | 2 | 3 | 2 |
| thallium | | boron group element atom | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| arsenic | | metalloid atom;
pnictogen | micronutrient | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| naltrexone | | cyclopropanes;
morphinane-like compound;
organic heteropentacyclic compound | antidote to opioid poisoning;
central nervous system depressant;
environmental contaminant;
mu-opioid receptor antagonist;
xenobiotic | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| gallium | | boron group element atom | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sulfur | | chalcogen;
nonmetal atom | macronutrient | 2018 | 2019 | 5.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| 5-methyl-2-hepten-4-one | | | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| methylazoxymethanol acetate | | azoxy compound | | 2009 | 2021 | 9.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| geldanamycin | | | | 2004 | 2010 | 18.0 | low | 0 | 0 | 0 | 4 | 0 | 0 |
| diphenylhexatriene | | alkatriene | fluorochrome | 2005 | 2011 | 16.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| dimyristoylphosphatidylcholine | | 1,2-diacyl-sn-glycero-3-phosphocholine;
phosphatidylcholine 28:0;
tetradecanoate ester | antigen;
mouse metabolite | 2004 | 2021 | 9.3 | low | 0 | 0 | 0 | 1 | 1 | 1 |
| ecdysterone | | 14alpha-hydroxy steroid;
20-hydroxy steroid;
22-hydroxy steroid;
25-hydroxy steroid;
2beta-hydroxy steroid;
3beta-sterol;
ecdysteroid;
phytoecdysteroid | animal metabolite;
plant metabolite | 2000 | 2004 | 22.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| deoxyribose | | deoxypentose | human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cysteine | | cysteinium | fundamental metabolite | 2003 | 2022 | 10.7 | low | 0 | 0 | 0 | 10 | 12 | 5 |
| silicon | | carbon group element atom;
metalloid atom;
nonmetal atom | | 2017 | 2021 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| phosphorus | | monoatomic phosphorus;
nonmetal atom;
pnictogen | macronutrient | 2012 | 2013 | 11.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| pepstatin | | pentapeptide;
secondary carboxamide | bacterial metabolite;
EC 3.4.23.* (aspartic endopeptidase) inhibitor | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| naltrindole | | isoquinolines | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| bafilomycin a | | | | 2012 | 2018 | 9.7 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| carbocyanines | | cyanine dye;
organic iodide salt | fluorochrome | 2005 | 2012 | 15.2 | low | 0 | 0 | 0 | 5 | 1 | 0 |
| 1,2-dielaidoylphosphatidylethanolamine | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| nitroblue formazan | | | | 2007 | 2007 | 17.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| ammonium sulfate | | ammonium salt;
inorganic sulfate salt | fertilizer | 2012 | 2022 | 6.3 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| monorden | | cyclic ketone;
enone;
epoxide;
macrolide antibiotic;
monochlorobenzenes;
phenols | antifungal agent;
metabolite;
tyrosine kinase inhibitor | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| coomassie brilliant blue | | | | 2001 | 2020 | 11.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| tetrodotoxin | | azatetracycloalkane;
oxatetracycloalkane;
quinazoline alkaloid | animal metabolite;
bacterial metabolite;
marine metabolite;
neurotoxin;
voltage-gated sodium channel blocker | 2004 | 2018 | 13.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| silatrane | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dizocilpine maleate | | maleate salt;
tetracyclic antidepressant | anaesthetic;
anticonvulsant;
neuroprotective agent;
nicotinic antagonist;
NMDA receptor antagonist | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| methylazoxymethanol | | azoxy compound | | 2009 | 2021 | 9.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| bongkrekic acid | | ether;
olefinic compound;
tricarboxylic acid | apoptosis inhibitor;
ATP/ADP translocase inhibitor;
bacterial metabolite;
EC 2.5.1.18 (glutathione transferase) inhibitor;
toxin | 2011 | 2017 | 10.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| 1-palmitoyl-2-oleoylphosphatidylcholine | | | | 1998 | 2019 | 13.2 | low | 0 | 0 | 1 | 7 | 13 | 0 |
| bafilomycin a1 | | cyclic hemiketal;
macrolide antibiotic;
oxanes | apoptosis inducer;
autophagy inhibitor;
bacterial metabolite;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
EC 3.6.3.14 (H(+)-transporting two-sector ATPase) inhibitor;
ferroptosis inhibitor;
fungicide;
potassium ionophore;
toxin | 2015 | 2017 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| cyanoginosin-la | | peptide | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dioleoyl phosphatidylethanolamine | | phosphatidylethanolamine | | 2018 | 2022 | 3.7 | low | 0 | 0 | 0 | 0 | 1 | 2 |
| bis(1,3-dibutylbarbiturate)trimethine oxonol | | | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| thermozymocidin | | alpha-amino fatty acid;
hydroxy monocarboxylic acid;
non-proteinogenic alpha-amino acid;
sphingoid | antifungal agent;
antimicrobial agent;
antineoplastic agent;
apoptosis inducer;
EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitor;
fungal metabolite;
immunosuppressive agent | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 2,3,5,4'-tetrahydroxystilbene 2-o-glucopyranoside | | | | 2013 | 2015 | 10.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| 1,2-dioleoylphosphatidylserine | | phosphatidylserine(18:1/18:1) | mouse metabolite | 2008 | 2021 | 6.7 | low | 0 | 0 | 0 | 1 | 4 | 2 |
| 1,2-linoleoylphosphatidylcholine | | | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sphingosyl beta-glucoside | | | | 2011 | 2023 | 8.4 | low | 0 | 0 | 0 | 0 | 4 | 1 |
| hydroxysafflor yellow a | | | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-oxo-2-nonenal | | enal;
enone | human metabolite | 2009 | 2023 | 8.1 | low | 0 | 0 | 0 | 1 | 5 | 2 |
| asialo gm1 ganglioside | | | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| salvianolic acid B | | 1-benzofurans;
catechols;
dicarboxylic acid;
enoate ester;
polyphenol | anti-inflammatory agent;
antidepressant;
antineoplastic agent;
antioxidant;
apoptosis inducer;
autophagy inhibitor;
cardioprotective agent;
hepatoprotective agent;
hypoglycemic agent;
neuroprotective agent;
osteogenesis regulator;
plant metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| i(3)so3-galactosylceramide | | galactosylceramide sulfate;
N-acyl-beta-D-galactosylsphingosine | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tanespimycin | | 1,4-benzoquinones;
ansamycin;
carbamate ester;
organic heterobicyclic compound;
secondary amino compound | antineoplastic agent;
apoptosis inducer;
Hsp90 inhibitor | 2010 | 2011 | 13.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| beta-escin | | | | 2013 | 2017 | 8.5 | low | 0 | 0 | 0 | 0 | 4 | 0 |
| melibiose | | glycosylglucose | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| lactacystin | | lactam;
S-substituted L-cysteine | | 2001 | 2021 | 15.5 | low | 0 | 0 | 0 | 17 | 6 | 1 |
| ergoline | | diamine;
ergoline alkaloid;
indole alkaloid fundamental parent;
indole alkaloid;
organic heterotetracyclic compound | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sq-23377 | | cyclic ether;
enol;
polyunsaturated fatty acid;
very long-chain fatty acid | calcium ionophore;
metabolite | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| xct790 | | cinnamamides | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| epsilon-(gamma-glutamyl)-lysine | | L-alpha-amino acid zwitterion;
N(6)-acyl-L-lysine | | 2004 | 2009 | 18.3 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| staurosporine | | ammonium ion derivative | | 2000 | 2016 | 16.9 | low | 0 | 0 | 1 | 5 | 2 | 0 |
| dioleoylphosphatidic acid | | 1,2-bis(octadec-9-enoyl)phosphatidic acid | | 2008 | 2017 | 11.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| formazans | | | | 2007 | 2008 | 16.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| fenpyroximate | | pyrazole acaricide;
tert-butyl ester | mitochondrial NADH:ubiquinone reductase inhibitor | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| davunetide | | oligopeptide | | 2011 | 2017 | 10.0 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| sincalide | | oligopeptide | | 2012 | 2015 | 10.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| ursodoxicoltaurine | | bile acid taurine conjugate | anti-inflammatory agent;
apoptosis inhibitor;
bone density conservation agent;
cardioprotective agent;
human metabolite;
neuroprotective agent | 2005 | 2020 | 10.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| sm 346 | | | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| mocetinostat | | aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline | antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent | 2004 | 2020 | 10.0 | low | 0 | 0 | 0 | 1 | 4 | 0 |
| alloin | | diastereoisomeric mixture | EC 1.14.18.1 (tyrosinase) inhibitor;
laxative | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| lipid a | | dodecanoate ester;
lipid A;
tetradecanoate ester | Escherichia coli metabolite | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pi103 | | aromatic amine;
morpholines;
organic heterotricyclic compound;
phenols;
tertiary amino compound | antineoplastic agent;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
mTOR inhibitor | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| mart-1 antigen | | | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ginsenoside rb1 | | ginsenoside;
glycoside;
tetracyclic triterpenoid | anti-inflammatory drug;
anti-obesity agent;
apoptosis inhibitor;
neuroprotective agent;
plant metabolite;
radical scavenger | 2015 | 2019 | 7.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| g(m2) ganglioside | | N-acetyl-beta-D-galactosaminyl-(1->4)-alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-N-acylsphingosine;
sialotriaosylceramide | antigen | 2007 | 2015 | 11.5 | low | 0 | 0 | 0 | 1 | 5 | 0 |
| msi 1436 | | bile acid | | 2018 | 2020 | 5.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| ginsenoside rg3 | | ginsenoside;
glycoside;
tetracyclic triterpenoid | angiogenesis modulating agent;
antineoplastic agent;
apoptosis inducer;
plant metabolite | 2013 | 2021 | 7.7 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| perampanel | | bipyridines;
nitrile;
pyridone | AMPA receptor antagonist;
anticonvulsant | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| olesoxime | | | | 2014 | 2020 | 7.7 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| tetramethylrhodamine | | xanthene dye | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| benzyloxycarbonyl-isoleucyl-glutamyl(o-tert-butyl)-alanyl-leucinal | | | | 2001 | 2012 | 17.8 | low | 0 | 0 | 0 | 3 | 1 | 0 |
| g(m1) ganglioside | | alpha-N-acetylneuraminosyl-(2->3)-[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphingosine;
sialotetraosylceramide | | 2007 | 2023 | 7.6 | low | 0 | 0 | 0 | 3 | 10 | 5 |
| 2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane | | | | 2008 | 2022 | 8.2 | low | 0 | 0 | 0 | 2 | 10 | 1 |
| methionine sulfoxide | | amino acid zwitterion;
L-methionine S-oxide | Escherichia coli metabolite | 2004 | 2018 | 13.4 | low | 0 | 0 | 0 | 4 | 3 | 0 |
| pimavanserin | | aromatic ether;
monofluorobenzenes;
piperidines;
tertiary amino compound;
ureas | 5-hydroxytryptamine 2A receptor inverse agonist;
antipsychotic agent;
serotonergic antagonist | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| corynoxine b | | indolizines | metabolite | 2017 | 2019 | 6.0 | high | 0 | 0 | 0 | 0 | 2 | 0 |
| azd 6244 | | benzimidazoles;
bromobenzenes;
hydroxamic acid ester;
monochlorobenzenes;
organofluorine compound;
secondary amino compound | anticoronaviral agent;
antineoplastic agent;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| a 443654 | | indoles | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| trans-sodium crocetinate | | | | 2018 | 2021 | 4.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| msdc-0160 | | aromatic ether | | 2016 | 2016 | 8.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| corynoxine | | indolizines | metabolite | 2017 | 2017 | 7.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| oxadiazoles | | | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ribose | | D-ribose;
ribopyranose | | 2010 | 2022 | 8.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| acebutolol | | alpha-D-glucosyl-(1->4)-D-mannopyranose | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 8-oxo-2'-deoxyadenosine | | purine 2'-deoxyribonucleoside | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| lactulose | | | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| hypoestoxide | | | | 2015 | 2015 | 9.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| calpain inhibitor iii | | | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| epoxomicin | | morpholines;
tripeptide | proteasome inhibitor | 2005 | 2013 | 14.5 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| phenylnitrene | | | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cardanol | | phenols | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| nystatin a1 | | nystatins | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| bi 2536 | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| vx 765 | | dipeptide | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| titanium boride | | | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| azd3241 | | | | 2015 | 2015 | 9.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| cannabidivarin | | monoterpenoid | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| losartan potassium | | | | 2011 | 2016 | 10.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| empagliflozin | | aromatic ether;
C-glycosyl compound;
monochlorobenzenes;
tetrahydrofuryl ether | hypoglycemic agent;
sodium-glucose transport protein subtype 2 inhibitor | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| calcimycin | | benzoxazole | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dextrothyroxine | | | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| veliparib | | benzimidazoles | EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sepharose | | | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| scopolamine hydrobromide | | | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 4'-diethylamino-3-hydroxyflavone | | | | 2009 | 2009 | 15.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| 24-hydroxycholesterol | | 24-hydroxy steroid;
3beta-hydroxy-Delta(5)-steroid;
oxysterol | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tenuigenin | | 12alpha-hydroxy steroid | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| acid phosphatase | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| eosine i bluish | | organic sodium salt | fluorescent dye;
histological dye | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| erythrosine | | | | 2000 | 2011 | 18.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| lyoniside | | | | 2014 | 2020 | 7.7 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| aegeline | | methoxybenzenes | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cyanidin-3-o-beta-glucopyranoside | | | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| homopropargylglycine | | | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| nad | | organophosphate oxoanion | cofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite | 2011 | 2022 | 6.9 | low | 0 | 0 | 0 | 0 | 6 | 2 |
| serofendic acid | | | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| mf 438 | | | | 2020 | 2020 | 4.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| cytochrome c-t | | | | 2004 | 2021 | 12.1 | low | 0 | 0 | 0 | 11 | 12 | 1 |
| gw 4869 | | | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| melitten | | | | 2011 | 2019 | 9.0 | low | 0 | 0 | 0 | 0 | 4 | 0 |
| cholecystokinin | | | | 2015 | 2022 | 5.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| atrial natriuretic factor | | polypeptide | | 2017 | 2020 | 5.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| peptide i | | | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| nociceptin | | organic molecular entity;
polypeptide | human metabolite;
rat metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| glucagon | | peptide hormone | | 2008 | 2022 | 8.2 | low | 0 | 0 | 0 | 1 | 2 | 1 |
| neuropeptide y | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| tannins | | | | 2017 | 2022 | 4.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| oligonucleotides | | | | 2005 | 2023 | 9.4 | low | 0 | 0 | 0 | 2 | 5 | 2 |
| liraglutide | | lipopeptide;
polypeptide | glucagon-like peptide-1 receptor agonist;
neuroprotective agent | 2019 | 2022 | 3.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| glucagon-like peptide 1 | | | | 2021 | 2022 | 2.3 | low | 0 | 0 | 0 | 0 | 0 | 3 |
| cellulose | | glycoside | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| endothelin-1 | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| phosphatidylcholines | | 1,2-diacyl-sn-glycero-3-phosphocholine | | 1998 | 2023 | 11.1 | low | 0 | 0 | 1 | 16 | 28 | 7 |
| azd 1480 | | | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| hoe 33342 | | | | 2008 | 2018 | 12.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| sodium salicylate | | organic molecular entity | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sphingosine kinase | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ubiquinone | | | | 2003 | 2019 | 14.6 | low | 0 | 0 | 0 | 8 | 5 | 0 |
| florbenazine f 18 | | | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1-palmitoyl-2-(6-(n-(7-nitrobenz)-2-oxa-1,3-diazol-4-yl)aminocaproyl)phosphatidylcholine | | 1,2-diacyl-sn-glycero-3-phosphocholine(1+) | fluorescent probe | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| calpain | | | | 2003 | 2023 | 12.4 | low | 0 | 0 | 0 | 9 | 12 | 2 |
| lucifer yellow | | organic lithium salt | fluorochrome | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| onjisaponin b | | triterpenoid saponin | | 2013 | 2015 | 10.0 | high | 0 | 0 | 0 | 0 | 2 | 0 |
| chitosan | | | | 2020 | 2022 | 3.0 | low | 0 | 0 | 0 | 0 | 1 | 2 |
| 2',3',4'-trihydroxyflavone | | | | 2020 | 2020 | 4.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| octyl galactopyranoside | | | | 2021 | 2021 | 3.0 | medium | 0 | 0 | 0 | 0 | 0 | 1 |
| bis(1,3-diethylthiobarbiturate)trimethineoxonol | | | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| bucladesine | | 3',5'-cyclic purine nucleotide | | 2003 | 2006 | 19.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| sodium lactate | | lactate salt;
organic sodium salt | food acidity regulator;
food preservative | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| sarkosyl | | | | 2001 | 2018 | 12.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| stearates | | | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| ro13-9904 | | | | 2010 | 2018 | 9.5 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| chiniofon | | | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| methyl jasmonate | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| s-adenosylmethionine | | organic cation;
sulfonium compound | coenzyme;
cofactor;
human metabolite;
micronutrient;
Mycoplasma genitalium metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| picrotoxin | | | | 2010 | 2020 | 7.8 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| pervanadate | | | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| egg white | | | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene | | BODIPY compound | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| quetiapine fumarate | | fumarate salt | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| apelin-13 peptide | | oligopeptide | antihypertensive agent;
autophagy inhibitor;
biomarker;
human metabolite;
neuroprotective agent | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| glycolipids | | | | 2006 | 2022 | 10.2 | low | 0 | 0 | 0 | 3 | 12 | 1 |
| piperidines | | | | 2007 | 2022 | 7.5 | low | 0 | 0 | 0 | 2 | 7 | 3 |
| resolvin d1 | | hydroxy polyunsaturated fatty acid;
resolvin;
triol | anti-inflammatory agent | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| thymosin | | | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| interleukin-8 | | | | 2006 | 2015 | 13.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| corynoxeine | | | | 2014 | 2014 | 10.0 | medium | 0 | 0 | 0 | 0 | 2 | 0 |
| 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1h-pyrazole | | | | 2014 | 2023 | 4.6 | high | 1 | 0 | 0 | 0 | 7 | 5 |
| exenatide | | | | 2017 | 2021 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| mannosylglycerate | | carbohydrate acid anion | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| calcipotriene | | hydrate | antipsoriatic | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tubastatin a | | hydroxamic acid;
pyridoindole;
tertiary amino compound | EC 3.5.1.98 (histone deacetylase) inhibitor | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1,2-dioleoyl-sn-glycero-3-phosphoglycerol | | 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) | | 2008 | 2019 | 9.2 | low | 0 | 0 | 0 | 1 | 4 | 0 |
| vasoactive intestinal peptide | | | | 2009 | 2014 | 12.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| heme | | | | 2015 | 2021 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1h-indol-5-yl)-7h-pyrrolo(2,3-d)pyrimidin-4-amine | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| heparitin sulfate | | | | 1999 | 2023 | 9.2 | low | 0 | 0 | 1 | 1 | 3 | 3 |
| ascorbic acid | | ascorbic acid;
vitamin C | coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent | 2010 | 2022 | 10.0 | low | 0 | 0 | 0 | 1 | 8 | 1 |
| tetracycline | | | | 2001 | 2019 | 15.2 | low | 0 | 0 | 0 | 3 | 1 | 0 |
| minocycline | | | | 2007 | 2020 | 11.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| salicylates | | monohydroxybenzoate | plant metabolite | 2017 | 2019 | 6.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| mobic | | 1,3-thiazoles;
benzothiazine;
monocarboxylic acid amide | analgesic;
antirheumatic drug;
cyclooxygenase 2 inhibitor;
non-steroidal anti-inflammatory drug | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| warfarin | | benzenes;
hydroxycoumarin;
methyl ketone | | 2011 | 2023 | 4.8 | low | 0 | 0 | 0 | 0 | 2 | 3 |
| metastat | | | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| epidermal growth factor | | | | 2012 | 2017 | 9.7 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| charybdotoxin | | | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| transforming growth factor beta | | | | 2017 | 2020 | 5.3 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| oleuropein aglycone | | catechols;
diester;
lactol;
methyl ester;
pyrans;
secoiridoid | anti-inflammatory agent;
antioxidant;
mTOR inhibitor;
neuroprotective agent;
plant metabolite;
TRPA1 channel agonist | 2020 | 2021 | 3.7 | medium | 0 | 0 | 0 | 0 | 2 | 1 |
| semaglutide | | lipopeptide;
polypeptide | anti-obesity agent;
appetite depressant;
glucagon-like peptide-1 receptor agonist;
hypoglycemic agent;
neuroprotective agent | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| okadaic acid | | ketal | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pyrethrins | | | | 2015 | 2020 | 7.0 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| globotriaosylceramide | | | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| gsk2578215a | | | | 2017 | 2018 | 6.5 | medium | 0 | 0 | 0 | 0 | 2 | 0 |
| maysin | | disaccharide derivative;
flavone C-glycoside;
secondary alpha-hydroxy ketone;
tetrahydroxyflavone | insecticide;
neuroprotective agent;
plant metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| kiss1 protein, human | | | | 2022 | 2023 | 1.5 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| fti 277 | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| greigite | | iron(2+) sulfides;
iron(3+) sulfides;
sulfide mineral | catalyst | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| bf 227 | | | | 2009 | 2018 | 11.2 | medium | 0 | 0 | 0 | 2 | 2 | 0 |
| ganglioside gm1alpha | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| caseins | | | | 2000 | 2018 | 16.4 | low | 0 | 0 | 1 | 4 | 2 | 0 |
| azd3759 | | | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| oligomycins | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| phthalocyanine | | phthalocyanines;
tetrapyrrole fundamental parent | | 2004 | 2011 | 16.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| g(m3) ganglioside | | alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide;
sialodiosylceramide;
sialotriaosylceramide | mouse metabolite | 2007 | 2023 | 10.3 | low | 0 | 0 | 0 | 2 | 3 | 1 |
| benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone | | | | 2001 | 2009 | 19.3 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| nitrophenols | | | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| difopein | | | | 2010 | 2021 | 8.5 | medium | 0 | 0 | 0 | 1 | 0 | 1 |
| calpastatin | | polypeptide | EC 3.4.22.52 (calpain-1) inhibitor;
EC 3.4.22.53 (calpain-2) inhibitor | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| hyaluronoglucosaminidase | | | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| ginkgolide k | | | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ginkgolide b | | | | 2017 | 2018 | 6.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| tro 40303 | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| peoniflorin | | | | 2011 | 2021 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| vitamin b 12 | | | | 2019 | 2020 | 4.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| ferric ammonium citrate | | | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| oxyntomodulin | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cyclosporine | | | | 2001 | 2020 | 9.4 | low | 0 | 0 | 0 | 1 | 7 | 0 |
| silybin | | | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| lactoferrin | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| myelin oligodendrocyte glycoprotein (35-55) | | | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| digitonin | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| catalpol | | | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| thromboplastin | | | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| muramidase | | | | 2001 | 2022 | 12.6 | low | 0 | 0 | 0 | 10 | 13 | 1 |
| amyloid beta-peptides | | | | 2001 | 2020 | 11.5 | low | 1 | 0 | 0 | 5 | 18 | 0 |
| amyloid beta-peptides | | | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| chondroitin sulfates | | | | 2012 | 2022 | 7.0 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| cyclic gmp | | 3',5'-cyclic purine nucleotide;
guanyl ribonucleotide | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2007 | 2021 | 10.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| deoxyguanosine | | purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2009 | 2015 | 12.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| guanosine triphosphate | | guanosine 5'-phosphate;
purine ribonucleoside 5'-triphosphate | Escherichia coli metabolite;
mouse metabolite;
uncoupling protein inhibitor | 2004 | 2022 | 10.8 | low | 0 | 0 | 0 | 1 | 2 | 1 |
| guanine | | 2-aminopurines;
oxopurine;
purine nucleobase | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2001 | 2021 | 15.5 | low | 0 | 0 | 0 | 2 | 1 | 1 |
| guanosine | | guanosines;
purines D-ribonucleoside | fundamental metabolite | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sapropterin | | 5,6,7,8-tetrahydrobiopterin | coenzyme;
cofactor;
diagnostic agent;
human metabolite | 2008 | 2019 | 10.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| folic acid | | folic acids;
N-acyl-amino acid | human metabolite;
mouse metabolite;
nutrient | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3-methyladenine | | | | 2012 | 2018 | 9.9 | low | 0 | 0 | 0 | 0 | 7 | 0 |
| queuine | | pyrrolopyrimidine | Escherichia coli metabolite | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| rifampin | | cyclic ketal;
hydrazone;
N-iminopiperazine;
N-methylpiperazine;
rifamycins;
semisynthetic derivative;
zwitterion | angiogenesis inhibitor;
antiamoebic agent;
antineoplastic agent;
antitubercular agent;
DNA synthesis inhibitor;
EC 2.7.7.6 (RNA polymerase) inhibitor;
Escherichia coli metabolite;
geroprotector;
leprostatic drug;
neuroprotective agent;
pregnane X receptor agonist;
protein synthesis inhibitor | 2004 | 2021 | 12.7 | low | 0 | 0 | 0 | 5 | 4 | 1 |
| 1-hydroxyphenazine | | phenazines | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sildenafil citrate | | citrate salt | EC 3.1.4.35 (3',5'-cyclic-GMP phosphodiesterase) inhibitor;
vasodilator agent | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 8-hydroxyguanine | | oxopurine | | 2001 | 2011 | 18.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| trypan blue | | | | 2012 | 2022 | 7.0 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| 8-hydroxy-2'-deoxyguanosine | | guanosines | biomarker | 2009 | 2015 | 12.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| pp242 | | aromatic amine;
biaryl;
hydroxyindoles;
phenols;
primary amino compound;
pyrazolopyrimidine | antineoplastic agent;
mTOR inhibitor | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| avermectin | | | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| eye | | | | 2012 | 2017 | 9.1 | low | 0 | 0 | 0 | 0 | 9 | 0 |
| dehydrorifampicin | | | | 2019 | 2019 | 5.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| frondoside a | | | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| carbidopa | | | | 2011 | 2023 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| amyloid beta-peptides | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| metallothionein | | | | 2003 | 2022 | 11.4 | low | 0 | 0 | 0 | 3 | 3 | 1 |
| leptin | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| hopeaphenol | | | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pyrimidinones | | | | 2012 | 2021 | 7.2 | low | 0 | 0 | 0 | 0 | 3 | 1 |
| phenanthrenes | | | | 2007 | 2017 | 12.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|
| (pPNET) Peripheral Primitive Neuroectodermal Tumors | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 2019 Novel Coronavirus Disease | 0 | | 2020 | 2023 | 2.1 | low | 0 | 0 | 0 | 0 | 3 | 24 |
| 22q11.2 Deletion Syndrome | 0 | | 2013 | 2019 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| 47,XX,+21 | 0 | | 1999 | 2016 | 18.0 | low | 0 | 0 | 4 | 1 | 3 | 0 |
| 5p Deletion Syndrome | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| a-Synucleinopathies | 0 | | 2019 | 2023 | 2.6 | high | 1 | 0 | 0 | 0 | 120 | 310 |
| Abdominal Migraine | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Aberrant Tissue | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Abnormal Deep Tendon Reflex | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Abnormal Movements | 0 | | 2015 | 2021 | 5.4 | low | 0 | 0 | 0 | 0 | 6 | 1 |
| Abnormalities, Autosome | 0 | | 1999 | 2013 | 18.0 | low | 0 | 0 | 1 | 2 | 1 | 0 |
| Abnormalities, Cardiovascular | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Abnormality, Torsion | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Absence Seizure | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Academic Disorder, Developmental | 0 | | 2001 | 2017 | 12.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Acetyl-CoA:alpha-Glucosaminide N-Acetyltransferase Deficiency | 0 | | 2012 | 2019 | 8.0 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| Ache | 0 | | 2004 | 2022 | 10.0 | low | 1 | 0 | 0 | 1 | 1 | 1 |
| Achromatopsia | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Acid Aspiration Syndrome | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Acid beta-Glucosidase Deficiency | 0 | | 2003 | 2023 | 7.8 | low | 0 | 0 | 0 | 4 | 61 | 19 |
| Acidosis | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Acquired Language Disorders | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Acquired Metabolic Diseases, Brain | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Acquired-Immune Deficiency Syndrome Dementia Complex | 0 | | 2006 | 2009 | 16.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Action Myoclonus-Renal Failure Syndrome | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Action Tremor | 0 | | 2003 | 2023 | 9.2 | low | 0 | 0 | 0 | 5 | 6 | 5 |
| Acute Brain Injuries | 0 | | 1999 | 2023 | 10.2 | low | 0 | 0 | 1 | 2 | 8 | 2 |
| Acute Confusional Senile Dementia | 0 | | 1994 | 2023 | 10.0 | low | 3 | 0 | 38 | 177 | 335 | 154 |
| Acute Disease | 0 | | 1999 | 2010 | 19.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Acute Disseminated Encephalomyelitis | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Acute Ischemic Stroke | 0 | | 2022 | 2023 | 1.3 | low | 0 | 0 | 0 | 0 | 0 | 3 |
| Acute Onset Vascular Dementia | 0 | | 2008 | 2020 | 10.0 | low | 0 | 0 | 0 | 2 | 4 | 0 |
| Acute Post-Traumatic Stress Disorder | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Acute Relapsing Multiple Sclerosis | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ADDH | 0 | | 2018 | 2019 | 5.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Adenocarcinoma | 0 | | 2000 | 2022 | 13.0 | low | 0 | 0 | 1 | 0 | 0 | 1 |
| Adenocarcinoma of Lung | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Adenocarcinoma, Basal Cell | 0 | | 2000 | 2022 | 13.0 | low | 0 | 0 | 1 | 0 | 0 | 1 |
| Adenohypophyseal Diseases | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Adenoma | 0 | | 2006 | 2015 | 13.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Adenoma, Basal Cell | 0 | | 2006 | 2015 | 13.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Adenoma, Prostatic | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Adiadochokinesis | 0 | | 2003 | 2021 | 11.4 | low | 0 | 0 | 0 | 3 | 3 | 1 |
| Adipocere | 0 | | 2000 | 2021 | 14.4 | low | 0 | 0 | 1 | 17 | 9 | 1 |
| Adrenal Cancer | 0 | | 2007 | 2016 | 12.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Adrenocorticotropic Hormone, Inappropriate Secretion | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Adrenoleukodystrophy, Autosomal Neonatal Form | 0 | | 2007 | 2010 | 15.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Adult Neuroaxonal Dystrophy | 0 | | 1999 | 2014 | 16.8 | low | 0 | 0 | 1 | 1 | 2 | 0 |
| Adult Neuronal Ceroid Lipofuscinosis | 0 | | 2013 | 2022 | 7.7 | low | 0 | 0 | 0 | 0 | 5 | 1 |
| Adult Sandhoff Disease | 0 | | 2003 | 2020 | 12.8 | low | 0 | 0 | 0 | 2 | 3 | 0 |
| Adult Spinal Muscular Atrophy | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Adult-Onset Dystonias | 0 | | 2001 | 2019 | 12.2 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| Advanced Sleep Phase Syndrome | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Adverse Drug Event | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Affective Psychosis, Bipolar | 0 | | 2006 | 2009 | 16.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Afibrinogenemia | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Afibrinogenemia, Congenital | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Age-Related Macular Degeneration | 0 | | 2006 | 2021 | 11.7 | low | 0 | 0 | 0 | 2 | 0 | 1 |
| Age-Related Memory Disorders | 0 | | 2001 | 2023 | 8.6 | low | 0 | 0 | 0 | 7 | 23 | 6 |
| Age-Related Osteoporosis | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Aggression | 0 | | 2009 | 2015 | 12.7 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Aging | 0 | | 1998 | 2023 | 11.1 | low | 0 | 0 | 4 | 78 | 135 | 21 |
| Aging, Premature | 0 | | 2006 | 2008 | 17.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Agitation, Psychomotor | 0 | | 2012 | 2018 | 8.3 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| AIDS Dementia Complex | 0 | | 2006 | 2009 | 16.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Akinetic-Rigid Variant of Huntington Disease | 0 | | 2000 | 2022 | 12.5 | low | 0 | 0 | 2 | 16 | 21 | 3 |
| AL Amyloidosis | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Alcaptonuria | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Alcohol Abuse | 0 | | 2004 | 2020 | 13.5 | low | 0 | 0 | 0 | 13 | 9 | 0 |
| Alcohol Abuse, Nervous System | 0 | | 2006 | 2010 | 15.7 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| Alcohol Drinking | 0 | | 2003 | 2020 | 13.0 | low | 0 | 0 | 0 | 6 | 4 | 0 |
| Alcohol Problem | 0 | | 2009 | 2015 | 11.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Alcohol-Related Disorders | 0 | | 2009 | 2015 | 11.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Alcoholic Cirrhosis | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Alcoholism | 0 | | 2004 | 2020 | 13.5 | low | 0 | 0 | 0 | 13 | 9 | 0 |
| Alexander Disease | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Alkaptonuria | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Allergic Encephalomyelitis | 0 | | 2005 | 2020 | 12.2 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| Alloxan Diabetes | 0 | | 2010 | 2020 | 9.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Alogia | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| alpha 1-Antitrypsin Deficiency | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| alpha-Galactosidase A Deficiency | 0 | | 2014 | 2023 | 5.0 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| ALS - Amyotrophic Lateral Sclerosis | 0 | | 1998 | 2023 | 10.1 | low | 0 | 0 | 3 | 13 | 36 | 9 |
| Alzheimer Disease | 0 | | 1994 | 2023 | 10.0 | low | 3 | 0 | 38 | 177 | 335 | 154 |
| Amaurotic Familial Idiocy | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Ambulation Disorders, Neurologic | 0 | | 2007 | 2020 | 9.8 | low | 0 | 0 | 0 | 3 | 17 | 0 |
| Amentia | 0 | | 1998 | 2023 | 11.8 | low | 0 | 0 | 16 | 63 | 90 | 23 |
| Amnesia | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Amnesia-Memory Loss | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Amphetamine Abuse | 0 | | 2004 | 2014 | 15.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Amphetamine-Related Disorders | 0 | | 2004 | 2014 | 15.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Amyloid Angiopathy, Cerebral | 0 | | 2002 | 2022 | 11.6 | low | 0 | 0 | 0 | 2 | 4 | 1 |
| Amyloid Deposits | 0 | | 1999 | 2023 | 13.4 | low | 0 | 0 | 8 | 43 | 35 | 9 |
| Amyloid Neuropathies | 0 | | 2008 | 2010 | 15.3 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| Amyloid Neuropathies, Familial | 0 | | 2007 | 2012 | 13.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Amyloid Neuropathy Type 1 | 0 | | 2007 | 2012 | 13.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Amyloidosis | 0 | | 2002 | 2023 | 8.4 | low | 0 | 0 | 0 | 14 | 16 | 21 |
| Amyloidosis, Familial | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Amyloidosis, Hereditary | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Amyotonia Congenita | 0 | | 2013 | 2023 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Amyotrophic Lateral Sclerosis | 0 | | 1998 | 2023 | 10.1 | low | 0 | 0 | 3 | 13 | 36 | 9 |
| Anaplastic Astrocytoma | 0 | | 2000 | 2006 | 21.8 | low | 0 | 0 | 1 | 3 | 0 | 0 |
| Anaplastic Ependymoma | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Anaplastic Oligodendroglioma | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Anemia | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Anemia, Iron-Deficiency | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Anemias, Iron-Deficiency | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Anesthesia | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Aneuploid | 0 | | 2015 | 2017 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Animal Diseases | 0 | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Anochlesia | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Anorexia Nervosa | 0 | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Anosmia | 0 | | 2021 | 2023 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Anoxemia | 0 | | 2004 | 2023 | 9.0 | low | 0 | 0 | 0 | 2 | 3 | 2 |
| Anoxia-Ischemia, Brain | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Anoxia, Brain | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ANS (Autonomic Nervous System) Diseases | 0 | | 2000 | 2022 | 12.3 | low | 0 | 0 | 1 | 14 | 13 | 3 |
| Anterior Cerebral Circulation Infarction | 0 | | 2010 | 2020 | 8.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Anterior Cervical Pain | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Anterior Choroidal Artery Infarction | 0 | | 2009 | 2010 | 14.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Anterior Circulation Transient Ischemic Attack | 0 | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Anterior Horn Cell Disease | 0 | | 1998 | 2021 | 15.1 | low | 0 | 0 | 1 | 4 | 2 | 1 |
| Antidiuretic Hormone, Inappropriate Secretion | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Anton Syndrome | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Antopol Disease | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Anxiety | 0 | | 2008 | 2023 | 10.0 | low | 0 | 0 | 0 | 6 | 9 | 3 |
| Anxiety Disorders | 0 | | 2012 | 2021 | 7.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Anxiety Neuroses | 0 | | 2012 | 2021 | 7.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Aphakia | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Aphasia | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Aphasia, Primary Progressive | 0 | | 2010 | 2013 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Apnea | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Apnea, Obstructive Sleep | 0 | | 2007 | 2019 | 7.4 | low | 0 | 0 | 0 | 1 | 4 | 0 |
| Apnea, Sleep | 0 | | 2001 | 2019 | 13.8 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| Apolipoprotein C-II Deficiency | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Apoplexy | 0 | | 2010 | 2023 | 4.9 | low | 0 | 0 | 0 | 1 | 6 | 5 |
| Appetite Disorders | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Aprosodia | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Arachnoidal Cerebellar Sarcoma, Circumscribed | 0 | | 2000 | 2018 | 17.0 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| Arsenic Encephalopathy | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Arteriolosclerosis | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| As If Personality | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Asthma | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Asthma, Bronchial | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Astrocytoma | 0 | | 2000 | 2006 | 21.8 | low | 0 | 0 | 1 | 3 | 0 | 0 |
| Astrocytoma, Grade IV | 0 | | 2003 | 2017 | 12.8 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| Astrocytosis | 0 | | 2000 | 2023 | 10.6 | low | 0 | 0 | 1 | 11 | 30 | 5 |
| Asymptomatic Conditions | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Asystole | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Ataxia | 0 | | 2007 | 2015 | 13.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Atherogenesis | 0 | | 2006 | 2013 | 13.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Atherosclerosis | 0 | | 2006 | 2013 | 13.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Atherosclerotic Parkinsonism | 0 | | 1998 | 2022 | 10.3 | low | 0 | 0 | 4 | 23 | 73 | 12 |
| Athletic Injuries | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 3 |
| Atrial Fibrillation | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Atrophy | 0 | | 2002 | 2022 | 9.4 | low | 0 | 0 | 0 | 7 | 13 | 4 |
| Atrophy, Muscle | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 3 |
| Atrophy, Muscular, Peroneal | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Atrophy, Muscular, Spinobulbar | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Attention Deficit Disorder with Hyperactivity | 0 | | 2018 | 2019 | 5.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Aura | 0 | | 2015 | 2020 | 6.5 | low | 0 | 0 | 0 | 0 | 4 | 0 |
| Aural Cholesteatoma | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Auricular Fibrillation | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Autism Spectrum Disorder | 0 | | 2015 | 2023 | 2.5 | low | 1 | 0 | 0 | 0 | 1 | 10 |
| Autoimmune Diabetes | 0 | | 2015 | 2022 | 4.3 | low | 0 | 0 | 0 | 0 | 1 | 2 |
| Autoimmune Disease | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Autoimmune Diseases | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Autonomic Failure, Progressive | 0 | | 2000 | 2014 | 15.3 | low | 0 | 0 | 1 | 2 | 3 | 0 |
| Autonomic Failure, Pure | 0 | | 2010 | 2022 | 7.6 | medium | 0 | 0 | 0 | 2 | 16 | 4 |
| Autosomal Chromosome Disorders | 0 | | 1999 | 2005 | 22.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Autosomal Dominant Cerebellar Ataxia, Type II | 0 | | 2001 | 2019 | 12.5 | low | 1 | 0 | 0 | 3 | 5 | 0 |
| Autosomal Dominant Hereditary Spastic Paraplegia | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Autosomal Dominant Juvenile Parkinson Disease | 0 | | 1999 | 2023 | 10.4 | low | 0 | 0 | 8 | 128 | 254 | 59 |
| Autosomal Dominant Striatonigral Degeneration | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Axon Reaction | 0 | | 2002 | 2021 | 10.7 | low | 0 | 0 | 0 | 1 | 1 | 1 |
| Axonotmesis | 0 | | 2003 | 2020 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| B16 Melanoma | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Bacterial Disease | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Bacterial Infections | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Bacterial Pneumonia | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Baltic Myoclonic Epilepsy | 0 | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Basal Ganglia Diseases | 0 | | 2001 | 2019 | 15.9 | low | 0 | 0 | 0 | 5 | 2 | 0 |
| Behavior Disorder, Rapid Eye Movement Sleep | 0 | | 2003 | 2023 | 7.0 | low | 0 | 0 | 0 | 15 | 48 | 32 |
| Behavior Disorders | 0 | | 2010 | 2019 | 9.0 | low | 0 | 0 | 0 | 1 | 6 | 0 |
| Benign Cerebellar Neoplasms | 0 | | 2000 | 2003 | 22.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Benign Essential Tremor | 0 | | 2001 | 2022 | 10.8 | low | 0 | 0 | 0 | 3 | 5 | 4 |
| Benign Neoplasms | 0 | | 1998 | 2023 | 9.9 | low | 0 | 0 | 2 | 0 | 9 | 3 |
| Benign Neoplasms, Brain | 0 | | 2000 | 2020 | 13.1 | low | 0 | 0 | 1 | 4 | 4 | 0 |
| Benign Psychomotor Epilepsy, Childhood | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| BH4 Deficiency | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Biological Clock Disturbances | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Bipolar Disorder | 0 | | 2006 | 2009 | 16.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Bladder Cancer | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Bladder Diseases | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Bladder Disorder, Neurogenic | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Blepharospasm | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Blood Poisoning | 0 | | 2019 | 2020 | 4.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Blunt Injuries | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Body Rocking | 0 | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Body Weight | 0 | | 2002 | 2022 | 9.6 | low | 0 | 0 | 0 | 4 | 12 | 2 |
| Bone Diseases, Metabolic | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Bone Loss, Perimenopausal | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Bovine Diseases | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Bovine Spongiform Encephalopathy | 0 | | 2011 | 2015 | 10.7 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| Bowel Diseases, Inflammatory | 0 | | 2015 | 2021 | 5.0 | low | 0 | 0 | 0 | 0 | 3 | 2 |
| Brachial Paresis | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Bradykinesia | 0 | | 2004 | 2022 | 13.0 | low | 0 | 0 | 0 | 5 | 2 | 1 |
| Brain Atrophy, Circumscribed Lobar | 0 | | 1999 | 2023 | 15.1 | low | 0 | 0 | 1 | 9 | 2 | 2 |
| Brain Concussion | 0 | | 2013 | 2023 | 4.2 | low | 0 | 0 | 0 | 0 | 3 | 3 |
| Brain Diseases | 0 | | 2000 | 2021 | 12.2 | low | 0 | 0 | 1 | 8 | 9 | 2 |
| Brain Diseases, Metabolic, Familial | 0 | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Brain Disorders | 0 | | 2000 | 2021 | 12.2 | low | 0 | 0 | 1 | 8 | 9 | 2 |
| Brain Edema | 0 | | 2010 | 2016 | 12.0 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| Brain Infarction | 0 | | 2010 | 2020 | 8.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Brain Inflammation | 0 | | 2000 | 2023 | 10.2 | low | 0 | 0 | 1 | 12 | 17 | 4 |
| Brain Injuries | 0 | | 1999 | 2023 | 10.2 | low | 0 | 0 | 1 | 2 | 8 | 2 |
| Brain Injuries, Traumatic | 0 | | 2016 | 2023 | 4.4 | low | 0 | 0 | 0 | 0 | 8 | 4 |
| Brain Injury, Chronic | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Brain Ischemia | 0 | | 2001 | 2021 | 10.8 | low | 0 | 0 | 0 | 3 | 7 | 1 |
| Brain Neoplasms | 0 | | 2000 | 2020 | 13.1 | low | 0 | 0 | 1 | 4 | 4 | 0 |
| Brain Swelling | 0 | | 2010 | 2016 | 12.0 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| Brain Vascular Disorders | 0 | | 2011 | 2020 | 7.6 | low | 0 | 0 | 0 | 0 | 5 | 0 |
| Breast Cancer | 0 | | 1998 | 2023 | 13.0 | low | 0 | 0 | 2 | 0 | 2 | 2 |
| Breast Neoplasms | 0 | | 1998 | 2023 | 13.0 | low | 0 | 0 | 2 | 0 | 2 | 2 |
| Breathing Sounds | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Breathlessness | 0 | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Bronze Diabetes | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Bulbo-Spinal Atrophy, X-Linked | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| CACH Syndrome | 0 | | 2012 | 2015 | 11.0 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| Cacosmia | 0 | | 2002 | 2023 | 9.1 | low | 0 | 0 | 0 | 5 | 23 | 3 |
| Cadaver | 0 | | 1998 | 2022 | 14.5 | low | 0 | 0 | 2 | 1 | 4 | 1 |
| Calcification, Pathologic | 0 | | 2002 | 2015 | 18.2 | low | 0 | 0 | 0 | 4 | 1 | 0 |
| Calcinosis | 0 | | 2002 | 2015 | 18.2 | low | 0 | 0 | 0 | 4 | 1 | 0 |
| Calculus, Dental | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Caliciviridae Infections | 0 | | 2017 | 2022 | 5.3 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| Cancer of Colon | 0 | | 2015 | 2017 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Cancer of Liver | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Cancer of Lung | 0 | | 2021 | 2023 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 3 |
| Cancer of Ovary | 0 | | 1998 | 2000 | 25.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Cancer of Pancreas | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Cancer of Parotid | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cancer of Pituitary | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Cancer of Prostate | 0 | | 2006 | 2013 | 14.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Cancer of Rectum | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cancer of Skin | 0 | | 2010 | 2016 | 11.2 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| Cancer of Stomach | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cancer Pain | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Cancer-Associated Pain | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Caprine Diseases | 0 | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Carcinogenesis | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Carcinoma | 0 | | 2000 | 2010 | 19.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Carcinoma, Anaplastic | 0 | | 2000 | 2010 | 19.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| Carcinoma, Ductal, Breast | 0 | | 1998 | 2000 | 25.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Carcinoma, Ductal, Pancreatic | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Carcinoma, Hepatocellular | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Carcinoma, Lewis Lung | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Carcinoma, Non-Small Cell Lung | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Carcinoma, Non-Small-Cell Lung | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Carcinoma, Pancreatic Ductal | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Cardiac Arrest, Sudden | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Cardiometabolic Syndrome | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Cardiovascular Abnormalities | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cardiovascular Diseases | 0 | | 2011 | 2022 | 6.8 | low | 0 | 0 | 0 | 0 | 3 | 1 |
| Cataract | 0 | | 2008 | 2017 | 10.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Cataract, Membranous | 0 | | 2008 | 2017 | 10.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Catarrh | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Catatonic Rigidity | 0 | | 2004 | 2017 | 12.6 | low | 0 | 0 | 0 | 2 | 3 | 0 |
| Cell Transformation, Neoplastic | 0 | | 2013 | 2023 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Cell Transformation, Viral | 0 | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Central Nervous System Disease | 0 | | 2009 | 2020 | 8.0 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| Central Nervous System Diseases | 0 | | 2009 | 2020 | 8.0 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| Central Nervous System Neoplasm | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Central Nervous System Neoplasms | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Cerebellar Ataxia | 0 | | 2003 | 2021 | 11.4 | low | 0 | 0 | 0 | 3 | 3 | 1 |
| Cerebellar Diseases | 0 | | 2005 | 2017 | 11.8 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| Cerebral Amyloid Angiopathy | 0 | | 2002 | 2022 | 11.6 | low | 0 | 0 | 0 | 2 | 4 | 1 |
| Cerebral Arteriosclerosis | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cerebral Concussion | 0 | | 2013 | 2023 | 4.2 | low | 0 | 0 | 0 | 0 | 3 | 3 |
| Cerebral Cortical Thinning | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Cerebral Infarction | 0 | | 2009 | 2010 | 14.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Cerebral Infarction, Middle Cerebral Artery | 0 | | 2019 | 2022 | 3.5 | low | 0 | 0 | 0 | 0 | 2 | 2 |
| Cerebral Ischemia | 0 | | 2001 | 2021 | 10.8 | low | 0 | 0 | 0 | 3 | 7 | 1 |
| Cerebral Malaria | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cerebral Microangiopathies | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cerebral Primitive Neuroectodermal Tumor | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Cerebral Pseudosclerosis | 0 | | 2013 | 2019 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Cerebral Small Vessel Diseases | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cerebromalacia | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cerebrovascular Disorders | 0 | | 2011 | 2020 | 7.6 | low | 0 | 0 | 0 | 0 | 5 | 0 |
| Channelopathies | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Charcot-Marie-Tooth Disease | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Chemical Dependence | 0 | | 2007 | 2011 | 14.7 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Chest Injuries | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Child Development Disorders, Pervasive | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Child Mental Disorders | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cholera Infantum | 0 | | 2009 | 2023 | 6.5 | low | 0 | 0 | 0 | 2 | 9 | 4 |
| Chorea | 0 | | 2003 | 2014 | 15.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Chorea Disorders | 0 | | 2003 | 2014 | 15.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Chromosomal Breakage | 0 | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Chromosomal Translocation | 0 | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Chromosomal Triplication | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Chromosome Deletion | 0 | | 2002 | 2017 | 15.0 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| Chromosome Instability Syndromes | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Chromosome Inversion | 0 | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Chromosome-Defective Micronuclei | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| chronic COVID syndrome | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 3 |
| Chronic Disease | 0 | | 2005 | 2023 | 8.5 | low | 0 | 0 | 0 | 3 | 9 | 1 |
| Chronic Encephalopathy, Post-Concussive | 0 | | 2017 | 2018 | 6.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Chronic Idiopathic Intestinal Pseudo-Obstruction | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Chronic Illness | 0 | | 2005 | 2023 | 8.5 | low | 0 | 0 | 0 | 3 | 9 | 1 |
| Chronic Insomnia | 0 | | 2005 | 2013 | 14.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Chronic Pain | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Chronic Primary Open Angle Glaucoma | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Chronic Traumatic Encephalopathy | 0 | | 2017 | 2018 | 6.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Cirrhosis | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| CJD (Creutzfeldt-Jakob Disease) | 0 | | 2002 | 2022 | 8.5 | low | 0 | 0 | 0 | 6 | 14 | 5 |
| Clasp-Knife Spasticity | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Classic Globoid Cell Leukodystrophy | 0 | | 2014 | 2022 | 5.6 | low | 0 | 0 | 0 | 0 | 3 | 2 |
| Classical Niemann-Pick Disease | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Clerambault Syndrome | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Clinically Isolated CNS Demyelinating Syndrome | 0 | | 2014 | 2023 | 6.2 | low | 0 | 0 | 0 | 0 | 3 | 2 |
| Cocaine Abuse | 0 | | 2003 | 2019 | 15.2 | low | 0 | 0 | 0 | 3 | 1 | 0 |
| Cocaine-Related Disorders | 0 | | 2003 | 2019 | 15.2 | low | 0 | 0 | 0 | 3 | 1 | 0 |
| Cognition Disorders | 0 | | 2000 | 2021 | 11.7 | low | 1 | 0 | 1 | 24 | 44 | 2 |
| Cognitive Decline | 0 | | 2012 | 2023 | 4.8 | low | 2 | 0 | 0 | 0 | 51 | 25 |
| Cognitive Dysfunction | 0 | | 2012 | 2023 | 4.8 | low | 2 | 0 | 0 | 0 | 51 | 25 |
| Colitis | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Colitis Gravis | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Colitis, Granulomatous | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Colitis, Ulcerative | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Colonic Inertia | 0 | | 2008 | 2023 | 7.1 | low | 0 | 0 | 0 | 3 | 10 | 3 |
| Colonic Neoplasms | 0 | | 2015 | 2017 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Color Vision Defects | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Colorectal Cancer | 0 | | 2010 | 2022 | 8.8 | low | 0 | 0 | 0 | 1 | 3 | 1 |
| Colorectal Neoplasms | 0 | | 2010 | 2022 | 8.8 | low | 0 | 0 | 0 | 1 | 3 | 1 |
| Common Cold | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Communicable Diseases | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Complication, Postoperative | 0 | | 2013 | 2020 | 7.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Complications of Diabetes Mellitus | 0 | | 2013 | 2018 | 7.7 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| Condition, Preneoplastic | 0 | | 2000 | 2011 | 18.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| Congenital Myotonic Dystrophy | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Conjugate Nystagmus | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Constipation | 0 | | 2008 | 2023 | 7.1 | low | 0 | 0 | 0 | 3 | 10 | 3 |
| Corneal Dystrophies | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Coronavirus Infections | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Corpus Luteum Cyst | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Cortical Lewy Body Disease | 0 | | 1999 | 2023 | 10.0 | high | 2 | 0 | 20 | 229 | 392 | 160 |
| Corticobasal Degeneration | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Coxsackie Virus Infections | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Cranial Nerve X Diseases | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Craniocerebral Injuries | 0 | | 1998 | 2021 | 11.3 | low | 1 | 0 | 1 | 0 | 4 | 1 |
| Craniocerebral Trauma | 0 | | 1998 | 2021 | 11.3 | low | 1 | 0 | 1 | 0 | 4 | 1 |
| Craniofacial Abnormalities | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Creutzfeldt-Jakob Syndrome | 0 | | 2002 | 2022 | 8.5 | low | 0 | 0 | 0 | 6 | 14 | 5 |
| Crohn Disease | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cryptogenic Infantile Spasms | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Curling Ulcer | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Cystadenocarcinoma, Papillary | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Cystic Fibrosis | 0 | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Cystic Fibrosis of Pancreas | 0 | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Cytomegalovirus | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Day Blindness | 0 | | 2018 | 2020 | 5.0 | low | 0 | 0 | 0 | 0 | 4 | 0 |
| Daytime Sleepiness | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| DDPAC | 0 | | 2011 | 2023 | 7.2 | low | 0 | 0 | 0 | 0 | 10 | 5 |
| Death, Sudden | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Death, Sudden, Cardiac | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Decreased Muscle Tone | 0 | | 2019 | 2022 | 3.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Deficiency, Mental | 0 | | 2012 | 2018 | 9.2 | low | 0 | 0 | 0 | 0 | 5 | 0 |
| Degenerative Disease, Nervous System, Hereditary | 0 | | 2000 | 2018 | 13.8 | low | 0 | 0 | 1 | 1 | 4 | 0 |
| Degenerative Diseases, Central Nervous System | 0 | | 1998 | 2024 | 9.2 | low | 3 | 0 | 19 | 219 | 424 | 246 |
| Deglutition Disorders | 0 | | 2013 | 2016 | 9.5 | low | 0 | 0 | 0 | 0 | 4 | 0 |
| Dejerine-Thomas Syndrome | 0 | | 2003 | 2023 | 11.1 | low | 0 | 0 | 0 | 4 | 1 | 3 |
| Delayed Effects, Prenatal Exposure | 0 | | 2004 | 2021 | 9.5 | low | 0 | 0 | 0 | 1 | 1 | 2 |
| Delirium | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Delirium of Mixed Origin | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Dementia | 0 | | 1998 | 2023 | 11.8 | low | 0 | 0 | 16 | 63 | 90 | 23 |
| Dementia Praecox | 0 | | 2006 | 2023 | 10.1 | low | 0 | 0 | 0 | 4 | 4 | 2 |
| Dementia, Vascular | 0 | | 2008 | 2020 | 10.0 | low | 0 | 0 | 0 | 2 | 4 | 0 |
| Dementias, Transmissible | 0 | | 2001 | 2023 | 8.6 | low | 0 | 0 | 0 | 13 | 44 | 8 |
| Demyelinating Diseases | 0 | | 2014 | 2023 | 6.2 | low | 0 | 0 | 0 | 0 | 3 | 2 |
| Depression | 0 | | 2007 | 2023 | 8.8 | low | 0 | 0 | 0 | 4 | 18 | 2 |
| Depression, Endogenous | 0 | | 2000 | 2012 | 15.3 | low | 0 | 0 | 1 | 2 | 3 | 0 |
| Depression, Involutional | 0 | | 2008 | 2021 | 7.4 | low | 0 | 0 | 0 | 2 | 3 | 2 |
| Depressive Disorder | 0 | | 2000 | 2012 | 15.3 | low | 0 | 0 | 1 | 2 | 3 | 0 |
| Depressive Disorder, Major | 0 | | 2008 | 2021 | 7.4 | low | 0 | 0 | 0 | 2 | 3 | 2 |
| Dermatoses | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Developmental Coordination Disorder | 0 | | 2008 | 2018 | 9.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Developmental Psychomotor Disorders | 0 | | 2004 | 2017 | 13.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Devic Disease | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Di Guglielmo Disease | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Diabetes Mellitus | 0 | | 2014 | 2022 | 5.5 | low | 0 | 0 | 0 | 0 | 7 | 1 |
| Diabetes Mellitus, Adult-Onset | 0 | | 2004 | 2023 | 5.2 | low | 0 | 0 | 0 | 3 | 12 | 15 |
| Diabetes Mellitus, Type 1 | 0 | | 2015 | 2022 | 4.3 | low | 0 | 0 | 0 | 0 | 1 | 2 |
| Diabetes Mellitus, Type 2 | 0 | | 2004 | 2023 | 5.2 | low | 0 | 0 | 0 | 3 | 12 | 15 |
| Diabetic Retinopathy | 0 | | 2015 | 2022 | 5.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Diathesis | 0 | | 2004 | 2023 | 5.4 | low | 0 | 0 | 0 | 1 | 12 | 8 |
| Diffuse Mixed Small and Large Cell Lymphoma | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Diffuse Neurofibrillary Tangles with Calcification | 0 | | 2011 | 2011 | 13.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| DiGeorge Syndrome | 0 | | 2013 | 2019 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Disbacteriosis | 0 | | 2015 | 2023 | 3.5 | low | 0 | 0 | 0 | 0 | 8 | 11 |
| Disease | 0 | | 2011 | 2017 | 10.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Disease Exacerbation | 0 | | 1998 | 2023 | 9.7 | low | 1 | 0 | 4 | 72 | 171 | 36 |
| Disease Models, Animal | 0 | | 2000 | 2024 | 8.5 | low | 1 | 0 | 5 | 234 | 777 | 266 |
| Disease, Pulmonary | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Diseases in Twins | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Disorders of Excessive Somnolence | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Disruptive, Impulse Control, and Conduct Disorders | 0 | | 2008 | 2017 | 11.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Down Syndrome | 0 | | 1999 | 2016 | 18.0 | low | 0 | 0 | 4 | 1 | 3 | 0 |
| Drooling | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Drug Abuse, Intravenous | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Drug Refractory Epilepsy | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Drug Withdrawal Symptoms | 0 | | 2008 | 2018 | 11.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Drug-Related Side Effects and Adverse Reactions | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Drusen, Retinal | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Duodenal Ulcer | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Duodenitis | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Dysarthosis | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Dysautonomia | 0 | | 2013 | 2021 | 5.0 | low | 0 | 0 | 0 | 0 | 3 | 3 |
| Dysesthesia | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Dyskinesia Syndromes | 0 | | 2000 | 2023 | 11.3 | low | 0 | 0 | 1 | 13 | 27 | 4 |
| Dyskinesia, Drug-Induced | 0 | | 2005 | 2016 | 15.0 | low | 0 | 0 | 0 | 3 | 1 | 0 |
| Dyskinesia, Medication-Induced | 0 | | 2005 | 2016 | 15.0 | low | 0 | 0 | 0 | 3 | 1 | 0 |
| Dysmyelopoietic Syndromes | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Dysphagia | 0 | | 2013 | 2016 | 9.5 | low | 0 | 0 | 0 | 0 | 4 | 0 |
| Dysplastic Nevus Syndrome, Hereditary | 0 | | 2016 | 2023 | 4.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Dyspnea | 0 | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Dystonia | 0 | | 2003 | 2019 | 13.3 | low | 0 | 0 | 0 | 4 | 3 | 0 |
| Dystonic Disorders | 0 | | 2001 | 2019 | 12.2 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| E coli Infections | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| EBV Infections | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Edema-Proteinuria-Hypertension Gestosis | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Electrolytes | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Electron Transport Chain Deficiencies, Mitochondrial | 0 | | 2003 | 2022 | 10.5 | low | 0 | 0 | 0 | 13 | 19 | 5 |
| Encephalitis | 0 | | 2000 | 2023 | 10.2 | low | 0 | 0 | 1 | 12 | 17 | 4 |
| Encephalitis Lethargica Type Parkinsonism | 0 | | 2002 | 2016 | 15.0 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Encephalitis, Viral | 0 | | 2017 | 2021 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Encephalomyopathies, Mitochondrial | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Encephalopathy, Hepatic | 0 | | 2010 | 2017 | 11.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Encephalopathy, Kuru | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Encephalopathy, Subacute Spongiform, Gerstmann-Straussler Type | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Encephalopathy, Toxic | 0 | | 2006 | 2023 | 6.3 | low | 0 | 0 | 0 | 3 | 22 | 20 |
| Encephalopathy, Traumatic | 0 | | 2016 | 2023 | 4.4 | low | 0 | 0 | 0 | 0 | 8 | 4 |
| Enteritis | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Ependymoma | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Epilepsy | 0 | | 2015 | 2020 | 6.5 | low | 0 | 0 | 0 | 0 | 4 | 0 |
| Epilepsy, Temporal Lobe | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Epstein-Barr Virus Infections | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Equine Diseases | 0 | | 2003 | 2021 | 13.8 | low | 0 | 0 | 0 | 2 | 1 | 1 |
| Erectile Dysfunction | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Erosive Duodenitis | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Escherichia coli Infections | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Essential Tremor | 0 | | 2001 | 2022 | 10.8 | low | 0 | 0 | 0 | 3 | 5 | 4 |
| Experimental Spinal Cord Ischemia | 0 | | 2009 | 2021 | 9.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| Extravascular Hemolysis | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Eye Cancer, Retinoblastoma | 0 | | 2001 | 2010 | 18.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Eye Diseases | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Eye Disorders | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Fabry Disease | 0 | | 2014 | 2023 | 5.0 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| Familial Fatal Insomnia | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Fatigue | 0 | | 2013 | 2020 | 9.0 | low | 0 | 0 | 0 | 0 | 5 | 0 |
| Fatty Liver, Nonalcoholic | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Feeding and Eating Disorders | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Fever | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Fibrosis | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Fra(X) Syndrome | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Fragile X Syndrome | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Friedreich Ataxia | 0 | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Friedreich Disease | 0 | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Frontotemporal Dementia | 0 | | 2011 | 2023 | 7.2 | low | 0 | 0 | 0 | 0 | 10 | 5 |
| Frontotemporal Lobar Degeneration | 0 | | 2009 | 2023 | 7.9 | low | 0 | 0 | 0 | 4 | 12 | 4 |
| Fungal Diseases | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| G(M2) Gangliosidoses | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Gait Disorders, Animal | 0 | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Gambling | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Gambling, Pathologic | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Ganglioglioma | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Ganglioneuroblastoma | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Gangliosidoses, GM2 | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Gastric Stasis | 0 | | 2015 | 2016 | 8.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Gastric Ulcer | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Gastritis | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Gastroenteritis | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Gastroparesis | 0 | | 2015 | 2016 | 8.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Gaucher Disease | 0 | | 2003 | 2023 | 7.8 | low | 0 | 0 | 0 | 4 | 61 | 19 |
| Gelineau Syndrome | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Genetic Diseases | 0 | | 2010 | 2011 | 13.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Genetic Diseases, Inborn | 0 | | 2010 | 2011 | 13.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Genetic Diseases, X-Chromosome Linked | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Genetic Predisposition | 0 | | 1998 | 2022 | 12.0 | low | 0 | 0 | 6 | 118 | 145 | 13 |
| Genome Instability | 0 | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Germinoblastoma | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Glaucoma | 0 | | 2005 | 2017 | 11.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Glaucoma, Open-Angle | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Glial Cell Tumors | 0 | | 2001 | 2020 | 12.8 | low | 0 | 0 | 0 | 5 | 6 | 0 |
| Glioblastoma | 0 | | 2003 | 2017 | 12.8 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| Glioma | 0 | | 2001 | 2020 | 12.8 | low | 0 | 0 | 0 | 5 | 6 | 0 |
| Grippe | 0 | | 2013 | 2020 | 7.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Group A Strep Infection | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Hakim Syndrome | 0 | | 2012 | 2022 | 6.2 | low | 0 | 0 | 0 | 0 | 4 | 2 |
| Hallervorden-Spatz Disease | 0 | | 1998 | 2013 | 21.9 | low | 0 | 0 | 5 | 1 | 1 | 0 |
| Hallucination of Body Sensation | 0 | | 2002 | 2023 | 12.1 | low | 0 | 0 | 0 | 8 | 7 | 2 |
| Hallucinations | 0 | | 2002 | 2023 | 12.1 | low | 0 | 0 | 0 | 8 | 7 | 2 |
| Headache, Tension | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Heart Arrest | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Heart Disease, Ischemic | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Heavy Metal Poisoning | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Heavy Metal Poisoning, Nervous System | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Helicobacter Infections | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hematologic Malignancies | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Hematologic Neoplasms | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Hemiplegia | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Hemiplegia, Crossed | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Hemochromatosis | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Hemolysis | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Hemorrhagic Fever with Renal Syndrome | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Hemorrhagic Fever, Epidemic | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Hemosiderosis | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hepatic Encephalopathy | 0 | | 2010 | 2017 | 11.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Hepatocellular Carcinoma | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Hepatolenticular Degeneration | 0 | | 2013 | 2019 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Heroin Abuse | 0 | | 2012 | 2015 | 10.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Heroin Dependence | 0 | | 2012 | 2015 | 10.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| HIV | 0 | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| HIV Coinfection | 0 | | 2009 | 2019 | 10.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| HIV Infections | 0 | | 2009 | 2019 | 10.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Hospital-Acquired Condition | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Huntington Disease | 0 | | 2000 | 2022 | 12.5 | low | 0 | 0 | 2 | 16 | 21 | 3 |
| Hydrocephalus, Normal Pressure | 0 | | 2012 | 2022 | 6.2 | low | 0 | 0 | 0 | 0 | 4 | 2 |
| Hydrophobia | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hymenolepiasis | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hyperactivity, Motor | 0 | | 2006 | 2017 | 13.0 | low | 0 | 0 | 0 | 3 | 3 | 0 |
| Hyperammonemia | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Hypercoagulability | 0 | | 2004 | 2013 | 15.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Hyperglycemia | 0 | | 2015 | 2022 | 4.3 | low | 0 | 0 | 0 | 0 | 1 | 2 |
| Hyperglycemia, Postprandial | 0 | | 2015 | 2022 | 4.3 | low | 0 | 0 | 0 | 0 | 1 | 2 |
| Hyperlipoproteinemia Type I | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hyperoxia | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hyperphagia | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hyperplasia | 0 | | 2000 | 2022 | 13.0 | low | 0 | 0 | 1 | 0 | 0 | 1 |
| Hypersomnolence, CNS, Idiopathic | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Hypertrophy | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Hypotension, Orthostatic | 0 | | 2001 | 2021 | 11.7 | low | 0 | 0 | 0 | 6 | 8 | 1 |
| Hypotension, Postural | 0 | | 2001 | 2021 | 11.7 | low | 0 | 0 | 0 | 6 | 8 | 1 |
| Hypoxia | 0 | | 2004 | 2023 | 9.0 | low | 0 | 0 | 0 | 2 | 3 | 2 |
| Hypoxia-Ischemia, Brain | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Idiopathic Hypersomnia | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Idiopathic Parkinson Disease | 0 | | 1997 | 2024 | 8.4 | high | 20 | 0 | 133 | 1,087 | 2,738 | 1,612 |
| Immunoglobulin Light-chain Amyloidosis | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Impotence | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Inadequate Sleep | 0 | | 2009 | 2022 | 8.5 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| Inappropriate ADH Syndrome | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Inborn Errors of Metabolism | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Inclusion Body Myopathy, Sporadic | 0 | | 2000 | 2013 | 15.6 | low | 0 | 0 | 1 | 1 | 3 | 0 |
| Infarction, Middle Cerebral Artery | 0 | | 2019 | 2022 | 3.5 | low | 0 | 0 | 0 | 0 | 2 | 2 |
| Infection | 0 | | 2019 | 2020 | 4.7 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| Infections | 0 | | 2019 | 2020 | 4.7 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| Infections, Coronavirus | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Infections, Helicobacter | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Infections, Lentivirus | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Infections, Mycobacterium | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Infections, Orthomyxoviridae | 0 | | 2009 | 2020 | 9.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Infections, Reoviridae | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Infections, Respiratory | 0 | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Infections, RNA Virus | 0 | | 2015 | 2021 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Infections, Salmonella | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Infections, Staphylococcal | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Infectious Diseases | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Inflammation | 0 | | 2006 | 2023 | 5.8 | low | 0 | 0 | 0 | 16 | 123 | 70 |
| Inflammatory Bowel Diseases | 0 | | 2015 | 2021 | 5.0 | low | 0 | 0 | 0 | 0 | 3 | 2 |
| Influenza, Human | 0 | | 2013 | 2020 | 7.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Injuries, Spinal Cord | 0 | | 2016 | 2022 | 5.2 | low | 0 | 0 | 0 | 0 | 8 | 2 |
| Injury, Ischemia-Reperfusion | 0 | | 2006 | 2018 | 10.5 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| Innate Inflammatory Response | 0 | | 2006 | 2023 | 5.8 | low | 0 | 0 | 0 | 16 | 123 | 70 |
| Insulin Resistance | 0 | | 2011 | 2023 | 7.6 | low | 0 | 0 | 0 | 0 | 7 | 1 |
| Insulin Sensitivity | 0 | | 2011 | 2023 | 7.6 | low | 0 | 0 | 0 | 0 | 7 | 1 |
| Intellectual Disability | 0 | | 2012 | 2018 | 9.2 | low | 0 | 0 | 0 | 0 | 5 | 0 |
| Intestinal Diseases | 0 | | 2022 | 2023 | 1.5 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Intestinal Pseudo-Obstruction | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Intracranial Arteriosclerosis | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Intraocular Pressure | 0 | | 2017 | 2023 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Invasiveness, Neoplasm | 0 | | 2016 | 2018 | 7.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Iron Metabolism Disorders | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Iron Overload | 0 | | 2019 | 2023 | 3.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Ischemia | 0 | | 2008 | 2015 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Ischemic Attack, Transient | 0 | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Ischemic Stroke | 0 | | 2022 | 2023 | 1.3 | low | 0 | 0 | 0 | 0 | 0 | 3 |
| Kahler Disease | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Kidney Diseases | 0 | | 2010 | 2023 | 6.5 | low | 0 | 0 | 0 | 1 | 2 | 1 |
| Language Disorders | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Laryngeal Diseases | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Lassitude | 0 | | 2013 | 2020 | 9.0 | low | 0 | 0 | 0 | 0 | 5 | 0 |
| Late Onset Diseases | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Latent Infection | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Learning Disabilities | 0 | | 2001 | 2017 | 12.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Lesion of Sciatic Nerve | 0 | | 2006 | 2010 | 16.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Leucocythaemia | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Leukemia | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Leukemia, Erythroblastic, Acute | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Leukemia, Megakaryoblastic, Acute | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Leukemia, Megakaryocytic | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Leukodystrophy, Globoid Cell | 0 | | 2014 | 2022 | 5.6 | low | 0 | 0 | 0 | 0 | 3 | 2 |
| Lewy Body Disease | 0 | | 1999 | 2023 | 10.0 | high | 2 | 0 | 20 | 229 | 392 | 160 |
| Libman-Sacks Disease | 0 | | 2014 | 2019 | 7.5 | low | 1 | 0 | 0 | 0 | 2 | 0 |
| Lichen Planus, Oral | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Lipid Metabolism Disorders | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Lipidoses | 0 | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Liver Cirrhosis, Alcoholic | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Liver Neoplasms | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Long Sleeper Syndrome | 0 | | 2003 | 2023 | 7.2 | low | 0 | 0 | 0 | 2 | 10 | 4 |
| Low Bone Density | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Lung Adenocarcinoma | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Lung Diseases | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Lung Neoplasms | 0 | | 2021 | 2023 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 3 |
| Lupus Erythematosus, Systemic | 0 | | 2014 | 2019 | 7.5 | low | 1 | 0 | 0 | 0 | 2 | 0 |
| Lymph Node Metastasis | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Lymphocytopenia | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Lymphoma | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Lymphoma, Non-Hodgkin | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Lymphopenia | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Lysosomal Enzyme Disorders | 0 | | 2014 | 2021 | 6.5 | low | 0 | 0 | 0 | 0 | 7 | 1 |
| Lysosomal Enzyme Disorders, Nervous System | 0 | | 2002 | 2007 | 19.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Machado-Joseph Disease | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Macular Degeneration | 0 | | 2006 | 2021 | 11.7 | low | 0 | 0 | 0 | 2 | 0 | 1 |
| Malaria, Falciparum | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Malignant Melanoma | 0 | | 2010 | 2023 | 6.9 | low | 0 | 0 | 0 | 1 | 8 | 4 |
| Malnourishment | 0 | | 2010 | 2016 | 11.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Malnutrition | 0 | | 2010 | 2016 | 11.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Manganese Poisoning | 0 | | 2009 | 2020 | 8.6 | low | 0 | 0 | 0 | 1 | 4 | 0 |
| Medulloblastoma | 0 | | 2000 | 2018 | 17.0 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| Melanoma | 0 | | 2010 | 2023 | 6.9 | low | 0 | 0 | 0 | 1 | 8 | 4 |
| Memory Disorders | 0 | | 2001 | 2023 | 8.6 | low | 0 | 0 | 0 | 7 | 23 | 6 |
| Mental Disorders | 0 | | 2010 | 2019 | 9.0 | low | 0 | 0 | 0 | 1 | 6 | 0 |
| Metabolic Acidosis | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Metabolic Syndrome | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Metabolism, Inborn Errors | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Metastase | 0 | | 2014 | 2016 | 9.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Migraine Disorders | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Mitochondrial Diseases | 0 | | 2003 | 2022 | 10.5 | low | 0 | 0 | 0 | 13 | 19 | 5 |
| Mixed Pineocytoma-Pineoblastoma | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Mole, Skin | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Motor Disorders | 0 | | 2017 | 2023 | 3.9 | low | 0 | 0 | 0 | 0 | 4 | 4 |
| Motor Neuron Disease | 0 | | 1998 | 2021 | 15.1 | low | 0 | 0 | 1 | 4 | 2 | 1 |
| Movement Disorders | 0 | | 2000 | 2023 | 11.3 | low | 0 | 0 | 1 | 13 | 27 | 4 |
| MPTP Neurotoxicity Syndrome | 0 | | 2000 | 2023 | 10.0 | low | 0 | 0 | 2 | 18 | 52 | 8 |
| MS (Multiple Sclerosis) | 0 | | 2005 | 2023 | 9.9 | low | 0 | 0 | 0 | 5 | 4 | 3 |
| Mucopolysaccharidosis III | 0 | | 2012 | 2019 | 8.0 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| Multiple Myeloma | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Multiple Sclerosis | 0 | | 2005 | 2023 | 9.9 | low | 0 | 0 | 0 | 5 | 4 | 3 |
| Multiple Sclerosis, Relapsing-Remitting | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Multiple System Atrophy | 0 | | 1998 | 2023 | 9.1 | high | 3 | 0 | 21 | 122 | 275 | 146 |
| Multiple System Atrophy Syndrome | 0 | | 1998 | 2023 | 9.1 | high | 3 | 0 | 21 | 122 | 275 | 146 |
| Muscle Contraction | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Muscle Rigidity | 0 | | 2004 | 2017 | 12.6 | low | 0 | 0 | 0 | 2 | 3 | 0 |
| Muscle Spasticity | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Muscular Atrophy | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 3 |
| Muscular Atrophy, Spinal | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Mycobacterium Infections | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Mycoses | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Myelodysplastic Syndromes | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Myelopathy | 0 | | 2010 | 2012 | 12.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Myocardial Ischemia | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Myoclonic Jerk | 0 | | 2009 | 2019 | 11.2 | low | 0 | 0 | 0 | 3 | 3 | 0 |
| Myositis, Inclusion Body | 0 | | 2000 | 2013 | 15.6 | low | 0 | 0 | 1 | 1 | 3 | 0 |
| Myotonic Dystrophy | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Narcolepsy | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Neck Pain | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Necrosis | 0 | | 2000 | 2019 | 12.2 | low | 0 | 0 | 1 | 2 | 3 | 0 |
| Neoplasm Metastasis | 0 | | 2014 | 2016 | 9.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Neoplasms | 0 | | 1998 | 2023 | 9.9 | low | 0 | 0 | 2 | 0 | 9 | 3 |
| Nerve Degeneration | 0 | | 1995 | 2023 | 12.1 | low | 0 | 0 | 17 | 160 | 194 | 45 |
| Nerve Pain | 0 | | 2016 | 2021 | 5.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Nervous System Diseases | 0 | | 1998 | 2023 | 12.2 | low | 0 | 0 | 2 | 9 | 11 | 4 |
| Nervous System Disorders | 0 | | 1998 | 2023 | 12.2 | low | 0 | 0 | 2 | 9 | 11 | 4 |
| Neuralgia | 0 | | 2016 | 2021 | 5.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Neurilemmoma | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Neurilemoma | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Neuritis | 0 | | 2008 | 2013 | 13.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Neuroblastoma | 0 | | 1998 | 2023 | 10.4 | low | 0 | 0 | 4 | 73 | 87 | 47 |
| Neurocytoma | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Neurodegenerative Diseases | 0 | | 1998 | 2024 | 9.2 | low | 3 | 0 | 19 | 219 | 424 | 246 |
| Neurodevelopmental Disorders | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Neuroectodermal Tumors, Primitive | 0 | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Neuroectodermal Tumors, Primitive, Peripheral | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Neurogenic Inflammation | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Neuromuscular Diseases | 0 | | 2013 | 2023 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Neuromuscular Junction Diseases | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Neuromyelitis Optica | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Neuronal Ceroid-Lipofuscinoses | 0 | | 2013 | 2022 | 7.7 | low | 0 | 0 | 0 | 0 | 5 | 1 |
| Neurovisceral Storage Disease with Vertical Supranuclear Ophthalmoplegia | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Niemann-Pick Disease | 0 | | 2004 | 2016 | 14.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Niemann-Pick Disease, Type A | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Niemann-Pick Disease, Type C | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Niemann-Pick Diseases | 0 | | 2004 | 2016 | 14.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Non-alcoholic Fatty Liver Disease | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Obesity | 0 | | 2014 | 2022 | 6.4 | low | 0 | 0 | 0 | 0 | 5 | 2 |
| Ochronosis | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Oligodendroglioma | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Ophthalmoplegia, Progressive Supranuclear | 0 | | 1998 | 2023 | 13.2 | low | 1 | 0 | 3 | 23 | 18 | 7 |
| Optic Atrophy | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Orphan Diseases | 0 | | 2010 | 2021 | 8.5 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| Orthomyxoviridae Infections | 0 | | 2009 | 2020 | 9.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Osteogenic Sarcoma | 0 | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Osteoporosis | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Osteoporosis, Postmenopausal | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Osteoporotic Fractures | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Osteosarcoma | 0 | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Ovarian Cysts | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Ovarian Neoplasms | 0 | | 1998 | 2000 | 25.0 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| Pain | 0 | | 2004 | 2022 | 10.0 | low | 1 | 0 | 0 | 1 | 1 | 1 |
| Pain, Chronic | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Palsy | 0 | | 2003 | 2021 | 10.7 | low | 0 | 0 | 0 | 1 | 1 | 1 |
| Pancreatic Neoplasms | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Pantothenate Kinase-Associated Neurodegeneration | 0 | | 1998 | 2013 | 21.9 | low | 0 | 0 | 5 | 1 | 1 | 0 |
| Paralysis | 0 | | 2003 | 2021 | 10.7 | low | 0 | 0 | 0 | 1 | 1 | 1 |
| Parkinson Disease | 0 | | 1997 | 2024 | 8.4 | high | 20 | 0 | 133 | 1,087 | 2,738 | 1,612 |
| Parkinson Disease, Postencephalitic | 0 | | 2002 | 2016 | 15.0 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Parkinson Disease, Secondary | 0 | | 1998 | 2022 | 10.3 | low | 0 | 0 | 4 | 23 | 73 | 12 |
| Parkinsonian Disorders | 0 | | 1999 | 2023 | 10.4 | low | 0 | 0 | 8 | 128 | 254 | 59 |
| Parotid Neoplasms | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Peripheral Nerve Diseases | 0 | | 2010 | 2021 | 8.9 | low | 0 | 0 | 0 | 1 | 7 | 1 |
| Peripheral Nerve Neoplasms | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Peripheral Nervous System Diseases | 0 | | 2010 | 2021 | 8.9 | low | 0 | 0 | 0 | 1 | 7 | 1 |
| Peripheral Nervous System Neoplasms | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Peroxisomal Disorders | 0 | | 2007 | 2010 | 15.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Pervasive Child Development Disorders | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Phenylketonurias | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Pheochromocytoma | 0 | | 2007 | 2016 | 12.8 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| Pheochromocytoma, Extra-Adrenal | 0 | | 2007 | 2016 | 12.8 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| Pick Disease of the Brain | 0 | | 1999 | 2023 | 15.1 | low | 0 | 0 | 1 | 9 | 2 | 2 |
| Pinealoma | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Pituitary ACTH Hypersecretion | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Pituitary Diseases | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Pituitary Neoplasms | 0 | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| Plant Poisoning | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Plasmodium falciparum Malaria | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Pneumonia, Aspiration | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Pneumonia, Bacterial | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Pneumonia, Viral | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Polycystic Ovarian Syndrome | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Polycystic Ovary Syndrome | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Polyneuropathies | 0 | | 2004 | 2017 | 13.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Polyneuropathy, Acquired | 0 | | 2004 | 2017 | 13.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Polyuria | 0 | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Post-Concussion Symptoms | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Post-Concussion Syndrome | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Postoperative Complications | 0 | | 2013 | 2020 | 7.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Postural Orthostatic Tachycardia Syndrome | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Pre-Eclampsia | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Precancerous Conditions | 0 | | 2000 | 2011 | 18.5 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| Pregnancy | 0 | | 2002 | 2021 | 10.2 | low | 0 | 0 | 0 | 10 | 21 | 6 |
| Presbycusis | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Prodromal Characteristics | 0 | | 2013 | 2023 | 4.8 | low | 0 | 0 | 0 | 0 | 24 | 16 |
| Prostatic Hyperplasia | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Prostatic Neoplasms | 0 | | 2006 | 2013 | 14.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Protein Aggregation, Pathological | 0 | | 2013 | 2023 | 5.7 | medium | 0 | 0 | 0 | 0 | 351 | 87 |
| Protein Folding Diseases | 0 | | 2009 | 2023 | 7.4 | low | 0 | 0 | 0 | 1 | 60 | 8 |
| Psychomotor Agitation | 0 | | 2012 | 2018 | 8.3 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| Psychoses | 0 | | 2007 | 2022 | 9.0 | low | 0 | 0 | 0 | 1 | 4 | 2 |
| Psychoses, Drug | 0 | | 2004 | 2010 | 17.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Psychotic Disorders | 0 | | 2007 | 2022 | 9.0 | low | 0 | 0 | 0 | 1 | 4 | 2 |
| Pyrexia | 0 | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Recrudescence | 0 | | 2006 | 2010 | 16.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Rectal Neoplasms | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Reflex, Abnormal | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| REM Sleep Behavior Disorder | 0 | | 2003 | 2023 | 7.0 | low | 0 | 0 | 0 | 15 | 48 | 32 |
| Reperfusion Injury | 0 | | 2006 | 2018 | 10.5 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| Respiratory Sounds | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Respiratory Tract Infections | 0 | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Restless Leg Syndrome | 0 | | 2004 | 2020 | 13.2 | low | 0 | 0 | 0 | 2 | 3 | 0 |
| Restless Legs Syndrome | 0 | | 2004 | 2020 | 13.2 | low | 0 | 0 | 0 | 2 | 3 | 0 |
| Retinal Degeneration | 0 | | 2000 | 2021 | 12.2 | low | 0 | 0 | 1 | 1 | 2 | 1 |
| Retinal Detachment | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Retinal Diseases | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Retinal Pigment Epithelial Detachment | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Retinoblastoma | 0 | | 2001 | 2010 | 18.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Rida | 0 | | 2002 | 2021 | 13.8 | low | 0 | 0 | 0 | 3 | 1 | 1 |
| Salivary Gland Diseases | 0 | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Sandhoff Disease | 0 | | 2003 | 2020 | 12.8 | low | 0 | 0 | 0 | 2 | 3 | 0 |
| Sarcopenia | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 3 |
| Schizophrenia | 0 | | 2006 | 2023 | 10.1 | low | 0 | 0 | 0 | 4 | 4 | 2 |
| Sclerosis | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Seizures | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Sensation Disorders | 0 | | 2008 | 2021 | 9.4 | low | 0 | 0 | 0 | 1 | 3 | 1 |
| Sensitivity and Specificity | 0 | | 2003 | 2023 | 8.6 | low | 0 | 0 | 0 | 13 | 38 | 12 |
| Sepsis | 0 | | 2019 | 2020 | 4.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| Sexually Transmitted Diseases | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Sialorrhea | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Skin Diseases | 0 | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Skin Neoplasms | 0 | | 2010 | 2016 | 11.2 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| Sleep Apnea Syndromes | 0 | | 2001 | 2019 | 13.8 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| Sleep Apnea, Obstructive | 0 | | 2007 | 2019 | 7.4 | low | 0 | 0 | 0 | 1 | 4 | 0 |
| Sleep Disorders, Circadian Rhythm | 0 | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Sleep Initiation and Maintenance Disorders | 0 | | 2005 | 2013 | 14.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Sleep Wake Disorders | 0 | | 2003 | 2023 | 7.2 | low | 0 | 0 | 0 | 2 | 10 | 4 |
| Small Fiber Neuropathy | 0 | | 2019 | 2021 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Snoring | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Spasms, Infantile | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Spastic Paraplegia, Hereditary | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Spinal Cord Diseases | 0 | | 2010 | 2012 | 12.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Spinal Cord Injuries | 0 | | 2016 | 2022 | 5.2 | low | 0 | 0 | 0 | 0 | 8 | 2 |
| Spinal Diseases | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Spinocerebellar Ataxias | 0 | | 2001 | 2019 | 12.5 | low | 1 | 0 | 0 | 3 | 5 | 0 |
| Staphylococcal Infections | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Starvation | 0 | | 2007 | 2018 | 11.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Stomach Neoplasms | 0 | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Stomach Ulcer | 0 | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Streptococcal Infections | 0 | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Stress Disorders, Post-Traumatic | 0 | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Striatonigral Atrophy | 0 | | 2000 | 2022 | 12.9 | low | 0 | 0 | 1 | 2 | 3 | 1 |
| Stroke | 0 | | 2010 | 2023 | 4.9 | low | 0 | 0 | 0 | 1 | 6 | 5 |
| Submandibular Gland Diseases | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Substance Withdrawal Syndrome | 0 | | 2008 | 2018 | 11.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| Substance-Related Disorders | 0 | | 2007 | 2011 | 14.7 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Sunburn | 0 | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Supranuclear Palsy, Progressive | 0 | | 1998 | 2023 | 13.2 | low | 1 | 0 | 3 | 23 | 18 | 7 |
| Sweat Gland Diseases | 0 | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Symptom Cluster | 0 | | 2001 | 2023 | 13.8 | low | 0 | 0 | 0 | 4 | 0 | 1 |
| Syndrome | 0 | | 2001 | 2023 | 13.8 | low | 0 | 0 | 0 | 4 | 0 | 1 |
| Tauopathies | 0 | | 2003 | 2024 | 9.8 | low | 0 | 0 | 0 | 24 | 33 | 18 |
| Tay-Sachs Disease | 0 | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| TDP-43 Proteinopathies | 0 | | 2009 | 2021 | 9.6 | low | 0 | 0 | 0 | 2 | 5 | 2 |
| Tension-Type Headache | 0 | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Teratocarcinoma | 0 | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| Thrombophilia | 0 | | 2004 | 2013 | 15.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Trauma, Nervous System | 0 | | 2003 | 2020 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| Tremor | 0 | | 2003 | 2023 | 9.2 | low | 0 | 0 | 0 | 5 | 6 | 5 |
| Unverricht-Lundborg Syndrome | 0 | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Ureteral Obstruction | 0 | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Urinary Bladder Neoplasms | 0 | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| Urinary Bladder, Neurogenic | 0 | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Urinary Incontinence | 0 | | 2005 | 2015 | 15.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| Urinary Tract Diseases | 0 | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Urinary Tract Infections | 0 | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Urination Disorders | 0 | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Vascular Diseases | 0 | | 2011 | 2022 | 7.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| Viral Diseases | 0 | | 2009 | 2023 | 6.0 | low | 0 | 0 | 0 | 1 | 2 | 1 |
| Virus Diseases | 0 | | 2009 | 2023 | 6.0 | low | 0 | 0 | 0 | 1 | 2 | 1 |
| Wallerian Degeneration | 0 | | 2002 | 2014 | 15.9 | low | 0 | 0 | 0 | 7 | 2 | 0 |
| Weight Gain | 0 | | 2011 | 2020 | 7.0 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| Weight Loss | 0 | | 2012 | 2023 | 8.3 | low | 0 | 0 | 0 | 0 | 5 | 1 |
| Weight Reduction | 0 | | 2012 | 2023 | 8.3 | low | 0 | 0 | 0 | 0 | 5 | 1 |
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Co-administration of Nanowired DL-3-n-Butylphthalide (DL-NBP) Together with Mesenchymal Stem Cells, Monoclonal Antibodies to Alpha Synuclein and TDP-43 (TAR DNA-Binding Protein 43) Enhance Superior Neuroprotection in Parkinson's Disease Following ConcussiAdvances in neurobiology, , Volume: 32, 2023
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Equine pituitary pars intermedia dysfunction: a spontaneous model of synucleinopathy.Scientific reports, , 08-06, Volume: 11, Issue:1, 2021
Constitutive silencing of LRRK2 kinase activity leads to early glucocerebrosidase deregulation and late impairment of autophagy in vivo.Neurobiology of disease, , Volume: 159, 2021
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Alpha-synuclein differentially reduces surface expression of N-methyl-d-aspartate receptors in the aging human brain.Neurobiology of aging, , Volume: 90, 2020
Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice.Neurobiology of aging, , Volume: 91, 2020
Novel biomarkers for the evaluation of aging-induced proteinopathies.Biogerontology, , Volume: 21, Issue:5, 2020
Immunotherapies for Aging-Related Neurodegenerative Diseases-Emerging Perspectives and New Targets.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 17, Issue:3, 2020
Small vessel disease pathological changes in neurodegenerative and vascular dementias concomitant with autonomic dysfunction.Brain pathology (Zurich, Switzerland), , Volume: 30, Issue:1, 2020
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Associations of sleep characteristics with alpha-synuclein in cerebrospinal fluid in older adults.Annals of clinical and translational neurology, , Volume: 7, Issue:10, 2020
Regular Aerobic Exercise-Alleviated Dysregulation of CAMKIIα Carbonylation to Mitigate Parkinsonism via Homeostasis of Apoptosis With Autophagy.Journal of neuropathology and experimental neurology, , 01-01, Volume: 79, Issue:1, 2020
Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging ACS chemical biology, , 07-19, Volume: 14, Issue:7, 2019
The influence of tau, amyloid, alpha-synuclein, TDP-43, and vascular pathology in clinically normal elderly individuals.Neurobiology of aging, , Volume: 77, 2019
Anti-ageing and anti-Parkinsonian effects of natural flavonol, tambulin from Zanthoxyllum aramatum promotes longevity in Caenorhabditis elegans.Experimental gerontology, , Volume: 120, 2019
Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis.Nature communications, , 03-07, Volume: 10, Issue:1, 2019
Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease.Scientific reports, , 11-22, Volume: 9, Issue:1, 2019
Lasting spatial learning and memory deficits following chronic cerebral hypoperfusion are associated with hippocampal mitochondrial aging in rats.Neuroscience, , 09-01, Volume: 415, 2019
Layer-specific axonal degeneration of serotonergic fibers in the prefrontal cortex of aged A53T α-synuclein-expressing mice.Neurobiology of aging, , Volume: 80, 2019
Early impairment of epigenetic pattern in neurodegeneration: Additional mechanisms behind pyrethroid toxicity.Experimental gerontology, , Volume: 124, 2019
Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease.Molecular neurodegeneration, , 11-08, Volume: 14, Issue:1, 2019
[no title available]Aging, , 12-13, Volume: 10, Issue:12, 2018
G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice.Neurobiology of disease, , Volume: 120, 2018
Neuropathology and cognitive performance in self-reported cognitively healthy centenarians.Acta neuropathologica communications, , 07-23, Volume: 6, Issue:1, 2018
Analysis of age-related changes in psychosine metabolism in the human brain.PloS one, , Volume: 13, Issue:2, 2018
Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease.Autophagy, , Volume: 14, Issue:8, 2018
Impaired Fast Network Oscillations and Mitochondrial Dysfunction in a Mouse Model of Alpha-synucleinopathy (A30P).Neuroscience, , 05-01, Volume: 377, 2018
Sex differences in Alzheimer's disease and common neuropathologies of aging.Acta neuropathologica, , Volume: 136, Issue:6, 2018
Age-dependent elevations of oligomeric and phosphorylated alpha-synuclein synchronously occurs in the brain and gastrointestinal tract of cynomolgus monkeys.Neuroscience letters, , Jan-01, Volume: 662, 2018
N-palmitoylethanolamide Prevents Parkinsonian Phenotypes in Aged Mice.Molecular neurobiology, , Volume: 55, Issue:11, 2018
Phosphorylated α-Synuclein Accumulations and Lewy Body-like Pathology Distributed in Parkinson's Disease-Related Brain Areas of Aged Rhesus Monkeys Treated with MPTP.Neuroscience, , 05-21, Volume: 379, 2018
Measurements of auto-antibodies to α-synuclein in the serum and cerebral spinal fluids of patients with Parkinson's disease.Journal of neurochemistry, , Volume: 145, Issue:6, 2018
Minimal neuropathologic diagnosis for brain banking in the normal middle-aged and aged brain and in neurodegenerative disorders.Handbook of clinical neurology, , Volume: 150, 2018
Age-related Beta-synuclein Alters the p53/Mdm2 Pathway and Induces the Apoptosis of Brain Microvascular Endothelial Cells In Vitro.Cell transplantation, , Volume: 27, Issue:5, 2018
Depleting Trim28 in adult mice is well tolerated and reduces levels of α-synuclein and tau.eLife, , 06-04, Volume: 7, 2018
Age-dependent alpha-synuclein accumulation is correlated with elevation of mitochondrial TRPC3 in the brains of monkeys and mice.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 124, Issue:4, 2017
In vivo and in silico studies to identify mechanisms associated with Nurr1 modulation following early life exposure to permethrin in rats.Neuroscience, , 01-06, Volume: 340, 2017
Higher levels of myelin phospholipids in brains of neuronal α-Synuclein transgenic mice precede myelin loss.Acta neuropathologica communications, , 05-08, Volume: 5, Issue:1, 2017
Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice.Neuron, , Nov-15, Volume: 96, Issue:4, 2017
Brain tau deposition linked to systemic causes of death in normal elderly.Neurobiology of aging, , Volume: 50, 2017
Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice.Acta neuropathologica communications, , 03-14, Volume: 5, Issue:1, 2017
Interactions of pathological proteins in neurodegenerative diseases.Acta neuropathologica, , Volume: 134, Issue:2, 2017
Aging modifies the effect of GCH1 RS11158026 on DAT uptake and Parkinson's disease clinical severity.Neurobiology of aging, , Volume: 50, 2017
c-Abl and Parkinson's Disease: Mechanisms and Therapeutic Potential.Journal of Parkinson's disease, , Volume: 7, Issue:4, 2017
Lack of spontaneous age-related brain pathology in Octodon degus: a reappraisal of the model.Scientific reports, , 04-04, Volume: 7, 2017
Sleep fragmentation and Parkinson's disease pathology in older adults without Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:12, 2017
Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.Brain : a journal of neurology, , May-01, Volume: 140, Issue:5, 2017
Seeding and transgenic overexpression of alpha-synuclein triggers dendritic spine pathology in the neocortex.EMBO molecular medicine, , Volume: 9, Issue:5, 2017
Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation.Journal of neuroinflammation, , 08-02, Volume: 14, Issue:1, 2017
Evaluation of a DNA Aβ42 Vaccine in Aged NZW Rabbits: Antibody Kinetics and Immune Profile after Intradermal Immunization with Full-Length DNA Aβ42 Trimer.Journal of Alzheimer's disease : JAD, , Volume: 57, Issue:1, 2017
Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function.Autophagy, , 10-02, Volume: 12, Issue:10, 2016
Early-onset motor impairment and increased accumulation of phosphorylated α-synuclein in the motor cortex of normal aging mice are ameliorated by coenzyme Q.Experimental gerontology, , Volume: 81, 2016
DNA methylation in Parkinson's disease.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Brain aging and Parkinson's disease: New therapeutic approaches using drug delivery systems.Maturitas, , Volume: 84, 2016
Age-dependent defects of alpha-synuclein oligomer uptake in microglia and monocytes.Acta neuropathologica, , Volume: 131, Issue:3, 2016
Amelioration of neuronal cell death in a spontaneous obese rat model by dietary restriction through modulation of ubiquitin proteasome system.The Journal of nutritional biochemistry, , Volume: 33, 2016
Age- and brain region-dependent α-synuclein oligomerization is attributed to alterations in intrinsic enzymes regulating α-synuclein phosphorylation in aging monkey brains.Oncotarget, , Feb-23, Volume: 7, Issue:8, 2016
Progression of Behavioral and CNS Deficits in a Viable Murine Model of Chronic Neuronopathic Gaucher Disease.PloS one, , Volume: 11, Issue:9, 2016
Neuroprotection by Epigenetic Modulation in a Transgenic Model of Multiple System Atrophy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 13, Issue:4, 2016
Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease.Acta neuropathologica communications, , 06-23, Volume: 4, Issue:1, 2016
Altered Proteins in the Aging Brain.Journal of neuropathology and experimental neurology, , Volume: 75, Issue:4, 2016
Is age-related failure of metabolic reprogramming a principal mediator in idiopathic Parkinson's disease? Implications for treatment and inverse cancer risk.Medical hypotheses, , Volume: 93, 2016
Neuronal hemoglobin in mitochondria is reduced by forming a complex with α-synuclein in aging monkey brains.Oncotarget, , Feb-16, Volume: 7, Issue:7, 2016
FTY720/Fingolimod Reduces Synucleinopathy and Improves Gut Motility in A53T Mice: CONTRIBUTIONS OF PRO-BRAIN-DERIVED NEUROTROPHIC FACTOR (PRO-BDNF) AND MATURE BDNF.The Journal of biological chemistry, , 09-23, Volume: 291, Issue:39, 2016
Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain.The Journal of neuroscience : the official journal of the Society for Neuroscience, , May-27, Volume: 35, Issue:21, 2015
The loss of glucose-regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein (α-syn) toxicity to rat nigral neurons.Neurobiology of aging, , Volume: 36, Issue:6, 2015
Alpha-synuclein levels in blood plasma decline with healthy aging.PloS one, , Volume: 10, Issue:4, 2015
α-Synuclein staging in the amygdala of a Parkinson's disease model: cell types involved.The European journal of neuroscience, , Volume: 41, Issue:1, 2015
Parkinson's disease and age: The obvious but largely unexplored link.Experimental gerontology, , Volume: 68, 2015
Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease.Biomolecules, , Oct-16, Volume: 5, Issue:4, 2015
DNA methylation levels of α-synuclein intron 1 in the aging brain.Neurobiology of aging, , Volume: 36, Issue:12, 2015
Tetrahydroxystilbene glucoside ameliorates memory and movement functions, protects synapses and inhibits α-synuclein aggregation in hippocampus and striatum in aged mice.Restorative neurology and neuroscience, , Volume: 33, Issue:4, 2015
Distribution of α-synuclein in the spinal cord and dorsal root ganglia in an autopsy cohort of elderly persons.Acta neuropathologica communications, , Sep-15, Volume: 3, 2015
Longitudinal Metabolomics Profiling of Parkinson's Disease-Related α-Synuclein A53T Transgenic Mice.PloS one, , Volume: 10, Issue:8, 2015
Heroin abuse exaggerates age-related deposition of hyperphosphorylated tau and p62-positive inclusions.Neurobiology of aging, , Volume: 36, Issue:11, 2015
Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression.Acta neuropathologica communications, , Jul-25, Volume: 3, 2015
Mutations in LRRK2 potentiate age-related impairment of autophagic flux.Molecular neurodegeneration, , Jul-11, Volume: 10, 2015
Increased oligomerization and phosphorylation of α-synuclein are associated with decreased activity of glucocerebrosidase and protein phosphatase 2A in aging monkey brains.Neurobiology of aging, , Volume: 36, Issue:9, 2015
Mutant α-synuclein enhances firing frequencies in dopamine substantia nigra neurons by oxidative impairment of A-type potassium channels.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Oct-08, Volume: 34, Issue:41, 2014
[Pathogenetic mechanisms of dementia in the older patients with Parkinson's diseases].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, , Volume: 114, Issue:7, 2014
Biochemical assessment of precuneus and posterior cingulate gyrus in the context of brain aging and Alzheimer's disease.PloS one, , Volume: 9, Issue:8, 2014
A new Drosophila model to study the interaction between genetic and environmental factors in Parkinson's disease.Brain research, , Oct-02, Volume: 1583, 2014
Region specific mitochondrial impairment in mice with widespread overexpression of alpha-synuclein.Neurobiology of disease, , Volume: 70, 2014
The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models.Cell metabolism, , Jul-01, Volume: 20, Issue:1, 2014
Olfactory deficits in an alpha-synuclein fly model of Parkinson's disease.PloS one, , Volume: 9, Issue:5, 2014
Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb.Nature communications, , May-28, Volume: 5, 2014
Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson's disease.Neurobiology of aging, , Volume: 35, Issue:10, 2014
α-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy.Neurobiology of aging, , Volume: 35, Issue:10, 2014
Management of the aging risk factor for Parkinson's disease.Neurobiology of aging, , Volume: 35, Issue:4, 2014
Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice.Human molecular genetics, , Feb-01, Volume: 23, Issue:3, 2014
Non-motor parkinsonian pathology in aging A53T α-synuclein mice is associated with progressive synucleinopathy and altered enzymatic function.Journal of neurochemistry, , Volume: 128, Issue:4, 2014
Macrophages are unsuccessful in clearing aggregated alpha-synuclein from the gastrointestinal tract of healthy aged Fischer 344 rats.Anatomical record (Hoboken, N.J. : 2007), , Volume: 296, Issue:4, 2013
Increased SUMO-1 expression in the unilateral rotenone-lesioned mouse model of Parkinson's disease.Neuroscience letters, , Jun-07, Volume: 544, 2013
Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits.Human molecular genetics, , May-15, Volume: 22, Issue:10, 2013
A novel α-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of α-synuclein-GFP.Neurobiology of disease, , Volume: 56, 2013
Impairment of mitochondria in adult mouse brain overexpressing predominantly full-length, N-terminally acetylated human α-synuclein.PloS one, , Volume: 8, Issue:5, 2013
Castration induces Parkinson disease pathologies in young male mice via inducible nitric-oxide synthase.The Journal of biological chemistry, , Jul-19, Volume: 288, Issue:29, 2013
The impact of pathogenic mitochondrial DNA mutations on substantia nigra neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jun-26, Volume: 33, Issue:26, 2013
Alpha-synuclein expression patterns in the colonic submucosal plexus of the aging Fischer 344 rat: implications for biopsies in aging and neurodegenerative disorders?Neurogastroenterology and motility, , Volume: 25, Issue:9, 2013
Changes in amyloid-β and Tau in the cerebrospinal fluid of transgenic mice overexpressing amyloid precursor protein.Science translational medicine, , Jul-17, Volume: 5, Issue:194, 2013
Non-Alzheimer neurodegenerative pathologies and their combinations are more frequent than commonly believed in the elderly brain: a community-based autopsy series.Acta neuropathologica, , Volume: 126, Issue:3, 2013
Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease.PloS one, , Volume: 8, Issue:8, 2013
Impaired mitochondrial energy production and ABC transporter function-A crucial interconnection in dementing proteopathies of the brain.Mechanisms of ageing and development, , Volume: 134, Issue:10, 2013
Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model.Proceedings of the National Academy of Sciences of the United States of America, , Oct-15, Volume: 110, Issue:42, 2013
Exacerbated neuronal ceroid lipofuscinosis phenotype in Cln1/5 double-knockout mice.Disease models & mechanisms, , Volume: 6, Issue:2, 2013
Tetrahydroxystilbene glucoside antagonizes age-related α-synuclein overexpression in the hippocampus of APP transgenic mouse model of Alzheimer's disease.Restorative neurology and neuroscience, , Volume: 31, Issue:1, 2013
Comparison of α-synuclein immunoreactivity in the hippocampus between the adult and aged beagle dogs.Cellular and molecular neurobiology, , Volume: 33, Issue:1, 2013
Age-related appearance of dendritic inclusions in catecholaminergic brainstem neurons.Neurobiology of aging, , Volume: 34, Issue:1, 2013
Alzheimer's disease-related lesions.Journal of Alzheimer's disease : JAD, , Volume: 33 Suppl 1, 2013
Mechanisms underlying altered striatal synaptic plasticity in old A53T-α synuclein overexpressing mice.Neurobiology of aging, , Volume: 33, Issue:8, 2012
Evaluation of the role of SNCA variants in survival without neurological disease.PloS one, , Volume: 7, Issue:8, 2012
Feedback motif for the pathogenesis of Parkinson's disease.IET systems biology, , Volume: 6, Issue:3, 2012
Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation.Proceedings of the National Academy of Sciences of the United States of America, , Sep-11, Volume: 109, Issue:37, 2012
Dynamic modelling of protein and oxidative metabolisms simulates the pathogenesis of Parkinson's disease.IET systems biology, , Volume: 6, Issue:3, 2012
Macrophages associated with the intrinsic and extrinsic autonomic innervation of the rat gastrointestinal tract.Autonomic neuroscience : basic & clinical, , Jul-02, Volume: 169, Issue:1, 2012
Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H β-synuclein.Molecular brain, , Sep-26, Volume: 5, 2012
Increased α-synuclein phosphorylation and nitration in the aging primate substantia nigra.Cell death & disease, , May-31, Volume: 3, 2012
Late-onset Parkinsonism in NFκB/c-Rel-deficient mice.Brain : a journal of neurology, , Volume: 135, Issue:Pt 9, 2012
Regulation of iron-related molecules in the rat hippocampus: sex- and age-associated differences.Annals of clinical and laboratory science, ,Spring, Volume: 42, Issue:2, 2012
Increased dimerization of alpha-synuclein in erythrocytes in Gaucher disease and aging.Neuroscience letters, , Oct-24, Volume: 528, Issue:2, 2012
Alpha-synuclein transgenic mice display age-related slowing of gastrointestinal motility associated with transgene expression in the vagal system.Neurobiology of disease, , Volume: 48, Issue:1, 2012
Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias.Brain : a journal of neurology, , Volume: 135, Issue:Pt 12, 2012
Positive lysosomal modulation as a unique strategy to treat age-related protein accumulation diseases.Rejuvenation research, , Volume: 15, Issue:2, 2012
Pathogenic considerations in sporadic inclusion-body myositis, a degenerative muscle disease associated with aging and abnormalities of myoproteostasis.Journal of neuropathology and experimental neurology, , Volume: 71, Issue:8, 2012
Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate.Scientific reports, , Volume: 2, 2012
Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson's disease.Journal of neurochemistry, , Volume: 122, Issue:2, 2012
Age and α-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling.Neurobiology of disease, , Volume: 44, Issue:2, 2011
Circadian dysfunction in a mouse model of Parkinson's disease.Experimental neurology, , Volume: 232, Issue:1, 2011
CSF α-synuclein concentrations do not fluctuate over hours and are not correlated to amyloid β in humans.Neuroscience letters, , Oct-31, Volume: 504, Issue:3, 2011
Epidemiological neuropathology: the MRC Cognitive Function and Aging Study experience.Journal of Alzheimer's disease : JAD, , Volume: 25, Issue:2, 2011
Protein aggregation in the aging retina.Journal of neuropathology and experimental neurology, , Volume: 70, Issue:1, 2011
Increased expression of α-synuclein in aged human brain associated with neuromelanin accumulation.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 118, Issue:11, 2011
α-Synuclein, leucine-rich repeat kinase-2, and manganese in the pathogenesis of Parkinson disease.Neurotoxicology, , Volume: 32, Issue:5, 2011
Inducible dopaminergic glutathione depletion in an α-synuclein transgenic mouse model results in age-related olfactory dysfunction.Neuroscience, , Jan-13, Volume: 172, 2011
Absence of alpha-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice.Neurobiology of aging, , Volume: 31, Issue:5, 2010
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice.Proceedings of the National Academy of Sciences of the United States of America, , May-25, Volume: 107, Issue:21, 2010
A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice.PloS one, , Jul-07, Volume: 5, Issue:7, 2010
Parkinson disease: Progress towards a molecular biomarker for Parkinson disease.Nature reviews. Neurology, , Volume: 6, Issue:7, 2010
The genetics of Parkinson disease.Journal of geriatric psychiatry and neurology, , Volume: 23, Issue:4, 2010
Comparison of newly generated doublecortin-immunoreactive neuronal progenitors in the main olfactory bulb among variously aged gerbils.Neurochemical research, , Volume: 35, Issue:10, 2010
Aging enhances the neuroinflammatory response and alpha-synuclein nitration in rats.Neurobiology of aging, , Volume: 31, Issue:9, 2010
Alpha-synuclein deficiency affects brain Foxp1 expression and ultrasonic vocalization.Neuroscience, , Mar-31, Volume: 166, Issue:3, 2010
Lymphomonocyte alpha-synuclein levels in aging and in Parkinson disease.Neurobiology of aging, , Volume: 31, Issue:5, 2010
Synergistic effects of environmental risk factors and gene mutations in Parkinson's disease accelerate age-related neurodegeneration.Journal of neurochemistry, , Volume: 115, Issue:6, 2010
Ageing, neurodegeneration and Parkinson's disease.Age and ageing, , Volume: 39, Issue:2, 2010
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.Science (New York, N.Y.), , Sep-24, Volume: 329, Issue:5999, 2010
Mitochondrial α-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo.Neuroscience letters, , Dec-17, Volume: 486, Issue:3, 2010
Frontal lobe white matter hyperintensities and neurofibrillary pathology in the oldest old.Neurology, , Dec-07, Volume: 75, Issue:23, 2010
Ageing enhances alpha-synuclein, ubiquitin and endoplasmic reticular stress protein expression in the nigral neurons of Asian Indians.Neurochemistry international, , Volume: 57, Issue:5, 2010
Enhanced alpha-synuclein expression in human neurodegenerative diseases: pathogenetic and therapeutic implications.Current protein & peptide science, , Volume: 10, Issue:5, 2009
Age and Parkinson's disease-related neuronal death in the substantia nigra pars compacta.Journal of neural transmission. Supplementum, , Issue:73, 2009
Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein.The American journal of pathology, , Volume: 175, Issue:2, 2009
Parkinsonism in hiv-infected patients on highly active antiretroviral therapy.Neurology, , Aug-04, Volume: 73, Issue:5, 2009
Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction.Acta neuropathologica, , Volume: 117, Issue:6, 2009
Decreased alpha-synuclein expression in the aging mouse substantia nigra.Experimental neurology, , Volume: 220, Issue:2, 2009
[In-vivo imaging for pursuing molecular cascades in the pathogenesis of neurodegenerative diseases].Rinsho shinkeigaku = Clinical neurology, , Volume: 49, Issue:11, 2009
Aging and alpha-synuclein affect synaptic plasticity in the dentate gyrus.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 116, Issue:1, 2009
Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation.The Journal of clinical investigation, , Volume: 119, Issue:11, 2009
Nuclear and neuritic distribution of serine-129 phosphorylated alpha-synuclein in transgenic mice.Neuroscience, , Jun-02, Volume: 160, Issue:4, 2009
Investigating bacterial sources of toxicity as an environmental contributor to dopaminergic neurodegeneration.PloS one, , Oct-06, Volume: 4, Issue:10, 2009
Quantitation and mapping of cerebral detergent-insoluble proteins in the elderly.Brain pathology (Zurich, Switzerland), , Volume: 19, Issue:3, 2009
Alpha-synuclein immunopositive aggregates in the myenteric plexus of the aging Fischer 344 rat.Experimental neurology, , Volume: 220, Issue:1, 2009
Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-18, Volume: 29, Issue:7, 2009
Alpha- and gamma-synuclein proteins are present in cerebrospinal fluid and are increased in aged subjects with neurodegenerative and vascular changes.Dementia and geriatric cognitive disorders, , Volume: 26, Issue:1, 2008
Lewy body pathology involves cutaneous nerves.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:10, 2008
Mutant alpha-synuclein exacerbates age-related decrease of neurogenesis.Neurobiology of aging, , Volume: 29, Issue:6, 2008
Patterns and stages of alpha-synucleinopathy: Relevance in a population-based cohort.Neurology, , Mar-25, Volume: 70, Issue:13, 2008
C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging.PLoS genetics, , Mar-21, Volume: 4, Issue:3, 2008
Human-based studies on alpha-synuclein deposition and relationship to Parkinson's disease symptoms.Experimental neurology, , Volume: 209, Issue:1, 2008
Incidence and extent of Lewy body-related alpha-synucleinopathy in aging human olfactory bulb.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:11, 2008
Mitochondrial alterations in Parkinson's disease: new clues.Journal of neurochemistry, , Volume: 107, Issue:2, 2008
Transgenic mice overexpressing tyrosine-to-cysteine mutant human alpha-synuclein: a progressive neurodegenerative model of diffuse Lewy body disease.The Journal of biological chemistry, , Apr-11, Volume: 283, Issue:15, 2008
Systematic appraisal using immunohistochemistry of brain pathology in aged and demented subjects.Dementia and geriatric cognitive disorders, , Volume: 25, Issue:5, 2008
Favorable effects of a prolonged treatment with melatonin on the level of oxidative damage and neurodegeneration in senescence-accelerated mice.Journal of pineal research, , Volume: 45, Issue:3, 2008
Alpha-synuclein A30P point-mutation generates age-dependent nigrostriatal deficiency in mice.Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, , Volume: 59, Issue:2, 2008
Medicine. The yin-yang of sirtuins.Science (New York, N.Y.), , Jul-27, Volume: 317, Issue:5837, 2007
Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?Neurobiology of disease, , Volume: 25, Issue:1, 2007
Aging of the rat mesostriatal system: differences between the nigrostriatal and the mesolimbic compartments.Experimental neurology, , Volume: 204, Issue:1, 2007
A variable poly-T sequence modulates alpha-synuclein isoform expression and is associated with aging.Journal of neuroscience research, , May-15, Volume: 85, Issue:7, 2007
Dietary restriction modulates alpha-synuclein expression in the aging rat cortex and hippocampus.Synapse (New York, N.Y.), , Volume: 61, Issue:9, 2007
Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Apr-05, Volume: 26, Issue:14, 2006
Increased lifespan in transgenic Caenorhabditis elegans overexpressing human alpha-synuclein.Experimental gerontology, , Volume: 41, Issue:9, 2006
Alpha-synuclein and its neurotoxic fragment inhibit dopamine uptake into rat striatal synaptosomes. Relationship to nitric oxide.Neurochemistry international, , Volume: 49, Issue:4, 2006
Levels of mRNA coding for alpha-, beta-, and gamma-synuclein in the brains of newborn, juvenile, and adult rats.Journal of molecular neuroscience : MN, , Volume: 29, Issue:3, 2006
Elevated oxidative stress in the brain of senescence-accelerated mice at 5 months of age.Biogerontology, , Volume: 7, Issue:1, 2006
Enhanced sensitivity of dopaminergic neurons to rotenone-induced toxicity with aging.Parkinsonism & related disorders, , Volume: 12, Issue:4, 2006
Comparison of alpha-synuclein immunoreactivity and protein levels in ischemic hippocampal CA1 region between adult and aged gerbils and correlation with Cu,Zn-superoxide dismutase.Neuroscience research, , Volume: 55, Issue:4, 2006
Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease.Biochemical and biophysical research communications, , Oct-13, Volume: 349, Issue:1, 2006
Proteasome dysfunction in aged human alpha-synuclein transgenic mice.Neurobiology of disease, , Volume: 23, Issue:1, 2006
Critical appraisal of brain pathology staging related to presymptomatic and symptomatic cases of sporadic Parkinson's disease.Journal of neural transmission. Supplementum, , Issue:70, 2006
Pathophysiology of synuclein aggregation in Lewy body disease.Mechanisms of ageing and development, , Volume: 127, Issue:2, 2006
Haploinsufficiency for trkB and trkC receptors induces cell loss and accumulation of alpha-synuclein in the substantia nigra.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 19, Issue:12, 2005
Intrapallidal lipopolysaccharide injection increases iron and ferritin levels in glia of the rat substantia nigra and induces locomotor deficits.Neuroscience, , Volume: 135, Issue:3, 2005
Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA).Journal of neuropathology and experimental neurology, , Volume: 64, Issue:2, 2005
Whole-mount analysis reveals normal numbers of dopaminergic neurons following misexpression of alpha-Synuclein in Drosophila.Genesis (New York, N.Y. : 2000), , Volume: 41, Issue:4, 2005
Expression of alpha-synuclein in different brain parts of adult and aged rats.Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, , Volume: 56, Issue:1, 2005
Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA).Journal of neuropathology and experimental neurology, , Volume: 64, Issue:6, 2005
Neurodegenerative diseases caused by protein aggregation: a phenomenon at the borderline between molecular evolution and ageing.Pharmacological research, , Volume: 50, Issue:4, 2004
Phosphorylated alpha-synuclein in normal mouse brain.FEBS letters, , Aug-13, Volume: 572, Issue:1-3, 2004
Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Aug-18, Volume: 24, Issue:33, 2004
Axonal transport of human alpha-synuclein slows with aging but is not affected by familial Parkinson's disease-linked mutations.Journal of neurochemistry, , Volume: 88, Issue:2, 2004
Lewy body-related alpha-synucleinopathy in the aged human brain.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 111, Issue:10-11, 2004
Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila.Neuron, , Mar-27, Volume: 37, Issue:6, 2003
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[Lewy bodies, a misleading marker for Parkinson's disease?].Bulletin de l'Academie nationale de medecine, , Volume: 187, Issue:2, 2003
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Accumulation of phosphorylated alpha-synuclein in aging human brain.Journal of neuropathology and experimental neurology, , Volume: 62, Issue:6, 2003
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[Development of imaging-based diagnostic procedures for brain protein aging using a mouse model of tauopathy].Nihon yakurigaku zasshi. Folia pharmacologica Japonica, , Volume: 152, Issue:1
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Role of Alcohol Drinking in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis.International journal of molecular sciences, , Mar-27, Volume: 21, Issue:7, 2020
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alpha-Synuclein expression in the brain and blood during abstinence from chronic alcohol drinking in mice.Neuropharmacology, , Volume: 54, Issue:8, 2008
Elevated alpha synuclein mRNA levels are associated with craving in patients with alcoholism.Biological psychiatry, , Dec-15, Volume: 56, Issue:12, 2004
alpha-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and -nonpreferring rats.Proceedings of the National Academy of Sciences of the United States of America, , Apr-15, Volume: 100, Issue:8, 2003
Alpha-Synuclein in Alcohol Use Disorder, Connections with Parkinson's Disease and Potential Therapeutic Role of 5' Untranslated Region-Directed Small Molecules.Biomolecules, , 10-21, Volume: 10, Issue:10, 2020
Alpha sinuclein expression in blood and its relationship with chronic constipation in a population from Bogotá, D.C., with problems of alcohol consumptionBiomedica : revista del Instituto Nacional de Salud, , 06-15, Volume: 40, Issue:2, 2020
Ethanol (EtOH)-Related Behaviors in α-Synuclein Mutant Mice and Association of SNCA SNPs with Anxiety in EtOH-Dependent Patients.Alcoholism, clinical and experimental research, , Volume: 42, Issue:11, 2018
[Relationship between the Expression of α-syn and Neuronal Apoptosis in Brain Cortex of Acute Alcoholism Rats].Fa yi xue za zhi, , Volume: 32, Issue:6, 2016
Differential expression of α-synuclein splice variants in the brain of alcohol misusers: Influence of genotype.Drug and alcohol dependence, , Oct-01, Volume: 155, 2015
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Peripheral blood alpha-synuclein mRNA levels are elevated in cynomolgus monkeys that chronically self-administer ethanol.Alcohol (Fayetteville, N.Y.), , Volume: 38, Issue:1, 2006
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Joint analysis of the NACP-REP1 marker within the alpha synuclein gene concludes association with alcohol dependence.Human molecular genetics, , Apr-01, Volume: 14, Issue:7, 2005
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The Structural Combination of SIL and MODAG Scaffolds Fails to Enhance Binding to α-Synuclein but Reveals Promising Affinity to Amyloid β.Molecules (Basel, Switzerland), , May-10, Volume: 28, Issue:10, 2023
Plasma GFAP associates with secondary Alzheimer's pathology in Lewy body disease.Annals of clinical and translational neurology, , Volume: 10, Issue:5, 2023
Fluid and Biopsy Based Biomarkers in Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 20, Issue:4, 2023
Are patients with Parkinson's disease at a lower risk of catching the common cold? Propensity score matching.Parkinsonism & related disorders, , Volume: 106, 2023
Hippocampal Reduction of α-Synuclein via RNA Interference Improves Neuropathology in Alzheimer's Disease Mice.Journal of Alzheimer's disease : JAD, , Volume: 95, Issue:1, 2023
The Mediating Role of Inflammation in the Relationship Between α-Synuclein and Cognitive Functioning.The journals of gerontology. Series A, Biological sciences and medical sciences, , 02-24, Volume: 78, Issue:2, 2023
Clinical trials in dementia with Lewy bodies: the evolving concept of co-pathologies, patient selection and biomarkers.Current opinion in neurology, , 08-01, Volume: 36, Issue:4, 2023
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Neurodegeneration cell per cell.Neuron, , 03-15, Volume: 111, Issue:6, 2023
Probing physical properties of single amyloid fibrils using nanofluidic channels.Nanoscale, , Nov-30, Volume: 15, Issue:46, 2023
Identification of a Putative α-synuclein Radioligand Using an in silico Similarity Search.Molecular imaging and biology, , Volume: 25, Issue:4, 2023
The Mechanisms of the Roles of α-Synuclein, Amyloid-β, and Tau Protein in the Lewy Body Diseases: Pathogenesis, Early Detection, and Therapeutics.International journal of molecular sciences, , Jun-17, Volume: 24, Issue:12, 2023
Interaction Between the Glymphatic System and α-Synuclein in Parkinson's Disease.Molecular neurobiology, , Volume: 60, Issue:4, 2023
CSF alpha-synuclein aggregates by seed amplification and clinical presentation of AD.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 19, Issue:8, 2023
Distinct effects of SDC3 and FGFRL1 on selective neurodegeneration in AD and PD.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 37, Issue:2, 2023
Co-aggregation of α-synuclein with amyloid-β stabilizes β-sheet-rich oligomers and enhances the formation of β-barrels.Physical chemistry chemical physics : PCCP, , Nov-29, Volume: 25, Issue:46, 2023
Cognitive effects of Lewy body pathology in clinically unimpaired individuals.Nature medicine, , Volume: 29, Issue:8, 2023
Tau accumulation in degradative organelles is associated to lysosomal stress.Scientific reports, , 10-21, Volume: 13, Issue:1, 2023
Folium Hibisci Mutabilis extract, a potent autophagy enhancer, exhibits neuroprotective properties in multiple models of neurodegenerative diseases.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 109, 2023
Seed Amplification Assay as a Diagnostic Tool in Newly-Diagnosed Parkinson's Disease.Journal of Parkinson's disease, , Volume: 13, Issue:5, 2023
An amphiphilic material arginine-arginine-bile acid promotes α-synuclein amyloid formation.Nanoscale, , Jun-01, Volume: 15, Issue:21, 2023
Timing matters: A protective role of astrocyte reactivity in neurodegeneration.Neuron, , 08-02, Volume: 111, Issue:15, 2023
Endocytic pathways of pathogenic protein aggregates in neurodegenerative diseases.Traffic (Copenhagen, Denmark), , Volume: 24, Issue:10, 2023
A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibrils in Multiple System Atrophy.Journal of medicinal chemistry, , 09-14, Volume: 66, Issue:17, 2023
Tau seeds occur before earliest Alzheimer's changes and are prevalent across neurodegenerative diseases.Acta neuropathologica, , Volume: 146, Issue:1, 2023
The Strategies of Development of New Non-Toxic Inhibitors of Amyloid Formation.International journal of molecular sciences, , Feb-14, Volume: 24, Issue:4, 2023
Sigma-2 Receptors-From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases.International journal of molecular sciences, , Mar-26, Volume: 24, Issue:7, 2023
Conformational dynamics of α-synuclein and study of its intramolecular forces in the presence of selected compounds.Scientific reports, , 11-03, Volume: 13, Issue:1, 2023
Nanoscale imaging of individual amyloid aggregates extracted from brains of Alzheimer and Parkinson patients reveals presence of lipids in α-synuclein but not in amyloid βProtein science : a publication of the Protein Society, , Volume: 32, Issue:4, 2023
Associations of phosphorylated tau pathology with whole-hemisphere ex vivo morphometry in 7 tesla MRI.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 19, Issue:6, 2023
Phosphorylated α-synuclein in skin Schwann cells: a new biomarker for multiple system atrophy.Brain : a journal of neurology, , 03-01, Volume: 146, Issue:3, 2023
Extracellular vesicle biomarkers for cognitive impairment in Parkinson's disease.Brain : a journal of neurology, , 01-05, Volume: 146, Issue:1, 2023
Small molecule-based fluorescent probes for the detection of α-Synuclein aggregation states.Bioorganic & medicinal chemistry letters, , 04-15, Volume: 86, 2023
Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions.Proceedings of the National Academy of Sciences of the United States of America, , 03-28, Volume: 120, Issue:13, 2023
Novel systemic delivery of a peptide-conjugated antisense oligonucleotide to reduce α-synuclein in a mouse model of Alzheimer's disease.Neurobiology of disease, , 10-01, Volume: 186, 2023
Mixed pathology as a rule, not exception: Time to reconsider disease nosology.Handbook of clinical neurology, , Volume: 192, 2023
Decreased DHA-containing phospholipids in the neocortex of dementia with Lewy bodies are associated with soluble AβBrain pathology (Zurich, Switzerland), , Volume: 33, Issue:6, 2023
Biomarkers of diagnosis, prognosis, pathogenesis, response to therapy: Convergence or divergence? Lessons from Alzheimer's disease and synucleinopathies.Handbook of clinical neurology, , Volume: 192, 2023
Gene Expression Profiling as a Novel Diagnostic Tool for Neurodegenerative Disorders.International journal of molecular sciences, , Mar-17, Volume: 24, Issue:6, 2023
Implications of DNA Methylation in Lewy Body Pathology.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:1, 2023
Evaluation of N- and O-Linked Indole Triazines for a Dual Effect on α-Synuclein and Tau Aggregation.ACS chemical neuroscience, , 11-01, Volume: 14, Issue:21, 2023
Cross-sectional Associations of β-Amyloid, Tau, and Cerebrovascular Biomarkers With Neurodegeneration in Probable Dementia With Lewy Bodies.Neurology, , 02-21, Volume: 100, Issue:8, 2023
Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats.Cell death & disease, , 05-13, Volume: 14, Issue:5, 2023
Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies.Acta neuropathologica communications, , 03-16, Volume: 10, Issue:1, 2022
[A role of human microbiota in the development of neurodegenerative diseases].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, , Volume: 122, Issue:10, 2022
Perception of Fragmented Letters by Patients With Pathologically Confirmed Dementia With Lewy Bodies or Alzheimer Disease.Neurology, , 11-01, Volume: 99, Issue:18, 2022
Unique seeding profiles and prion-like propagation of synucleinopathies are highly dependent on the host in human α-synuclein transgenic mice.Acta neuropathologica, , Volume: 143, Issue:6, 2022
The amyloid concentric β-barrel hypothesis: Models of synuclein oligomers, annular protofibrils, lipoproteins, and transmembrane channels.Proteins, , Volume: 90, Issue:2, 2022
Tailoring a Nanochaperone to Regulate α-Synuclein Assembly.Angewandte Chemie (International ed. in English), , 05-02, Volume: 61, Issue:19, 2022
Biofluid-based biomarkers for Alzheimer's disease-related pathologies: An update and synthesis of the literature.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 18, Issue:9, 2022
Amyloids on Membrane Interfaces: Implications for Neurodegeneration.The Journal of membrane biology, , Volume: 255, Issue:6, 2022
Endogenous Human Proteins Interfering with Amyloid Formation.Biomolecules, , 03-14, Volume: 12, Issue:3, 2022
A53T α-synuclein induces neurogenesis impairment and cognitive dysfunction in line M83 transgenic mice and reduces the proliferation of embryonic neural stem cells.Brain research bulletin, , Volume: 182, 2022
Liquid-Liquid Phase Separation Promotes Protein Aggregation and Its Implications in Ferroptosis in Parkinson's Disease Dementia.Oxidative medicine and cellular longevity, , Volume: 2022, 2022
Natural speech markers of Alzheimer's disease co-pathology in Lewy body dementias.Parkinsonism & related disorders, , Volume: 102, 2022
MCC950 ameliorates the dementia symptom at the early age of line M83 mouse and reduces hippocampal α-synuclein accumulation.Biochemical and biophysical research communications, , 06-30, Volume: 611, 2022
Molecular Insights into the Effect of Metals on Amyloid Aggregation.Methods in molecular biology (Clifton, N.J.), , Volume: 2340, 2022
Characterization of molecular biomarkers in cerebrospinal fluid and serum of E46K-SNCA mutation carriers.Parkinsonism & related disorders, , Volume: 96, 2022
De novo designed protein inhibitors of amyloid aggregation and seeding.Proceedings of the National Academy of Sciences of the United States of America, , 08-23, Volume: 119, Issue:34, 2022
The Role of Amyloid-β, Tau, and α-Synuclein Proteins as Putative Blood Biomarkers in Patients with Cerebral Amyloid Angiopathy.Journal of Alzheimer's disease : JAD, , Volume: 89, Issue:3, 2022
Modulation of Inflammatory Mediators and Microglial Activation Through Physical Exercise in Alzheimer's and Parkinson's Diseases.Neurochemical research, , Volume: 47, Issue:11, 2022
Dityrosine Cross-links are Present in Alzheimer's Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297-391) In Vitro.Journal of molecular biology, , 10-15, Volume: 434, Issue:19, 2022
Propagation of tau and α-synuclein in the brain: therapeutic potential of the glymphatic system.Translational neurodegeneration, , 03-21, Volume: 11, Issue:1, 2022
Differentiating dementia with Lewy bodies from Alzheimer's disease and Parkinson's disease dementia: an update on imaging modalities.Journal of neurology, , Volume: 269, Issue:2, 2022
Quantifying regional α -synuclein, amyloid β, and tau accumulation in lewy body dementia.Annals of clinical and translational neurology, , Volume: 9, Issue:2, 2022
α-synuclein-assisted oligomerization of β-amyloid (1-42).Archives of biochemistry and biophysics, , 03-15, Volume: 717, 2022
Alpha-synuclein: a pathological factor with Aβ and tau and biomarker in Alzheimer's disease.Alzheimer's research & therapy, , 12-31, Volume: 14, Issue:1, 2022
Functional Cooperation of α-Synuclein and Tau Is Essential for Proper Corticogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 09-14, Volume: 42, Issue:37, 2022
Emerging urinary alpha-synuclein and miRNA biomarkers in Parkinson's disease.Metabolic brain disease, , Volume: 37, Issue:6, 2022
Immunohistochemical Demonstration of the pGlu79 α-Synuclein Fragment in Alzheimer's Disease and Its Tg2576 Mouse Model.Biomolecules, , 07-20, Volume: 12, Issue:7, 2022
APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer's disease with Lewy body pathology.Acta neuropathologica, , Volume: 143, Issue:6, 2022
Cerebrospinal Fluid Alpha-Synuclein Improves the Differentiation between Dementia with Lewy Bodies and Alzheimer's Disease in Clinical Practice.International journal of molecular sciences, , Nov-04, Volume: 23, Issue:21, 2022
AmyP53, a Therapeutic Peptide Candidate for the Treatment of Alzheimer's and Parkinson's Disease: Safety, Stability, Pharmacokinetics Parameters and Nose-to Brain Delivery.International journal of molecular sciences, , Nov-02, Volume: 23, Issue:21, 2022
Prions and Neurodegenerative Diseases: A Focus on Alzheimer's Disease.Journal of Alzheimer's disease : JAD, , Volume: 85, Issue:2, 2022
Could Amyloid-β 1-42 or α-Synuclein Interact Directly with Mitochondrial DNA? A Hypothesis.ACS chemical neuroscience, , 10-05, Volume: 13, Issue:19, 2022
Error-prone protein synthesis recapitulates early symptoms of Alzheimer disease in aging mice.Cell reports, , 09-27, Volume: 40, Issue:13, 2022
Overlap between Central and Peripheral Transcriptomes in Parkinson's Disease but Not Alzheimer's Disease.International journal of molecular sciences, , May-06, Volume: 23, Issue:9, 2022
Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases.Progress in neurobiology, , Volume: 214, 2022
Axonal degeneration in the anterior insular cortex is associated with Alzheimer's co-pathology in Parkinson's disease and dementia with Lewy bodies.Translational neurodegeneration, , 12-07, Volume: 11, Issue:1, 2022
Effect of olfactory bulb pathology on olfactory function in normal aging.Brain pathology (Zurich, Switzerland), , Volume: 32, Issue:5, 2022
α-synuclein as an emerging pathophysiological biomarker of Alzheimer's disease.Expert review of molecular diagnostics, , Volume: 22, Issue:4, 2022
SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex.Acta neuropathologica communications, , 12-14, Volume: 10, Issue:1, 2022
Exploring the brain metabolic correlates of process-specific CSF biomarkers in patients with MCI due to Alzheimer's disease: preliminary data.Neurobiology of aging, , Volume: 117, 2022
Diagnostic value of plasma p-tau181, NfL, and GFAP in a clinical setting cohort of prevalent neurodegenerative dementias.Alzheimer's research & therapy, , 10-12, Volume: 14, Issue:1, 2022
Distinct Aβ pathology in the olfactory bulb and olfactory deficits in a mouse model of Aβ and α-syn co-pathology.Brain pathology (Zurich, Switzerland), , Volume: 32, Issue:3, 2022
The promise of amplification assays for accurate early detection of α-synucleinopathies: A review.Experimental gerontology, , Volume: 165, 2022
1-Indanone and 1,3-indandione Derivatives as Ligands for Misfolded α-Synuclein Aggregates.ChemMedChem, , 01-19, Volume: 17, Issue:2, 2022
Biomarkers Related to Synaptic Dysfunction to Discriminate Alzheimer's Disease from Other Neurological Disorders.International journal of molecular sciences, , Sep-16, Volume: 23, Issue:18, 2022
Relevance of plasma biomarkers to pathologies in Alzheimer's disease, Parkinson's disease and frontotemporal dementia.Scientific reports, , 10-26, Volume: 12, Issue:1, 2022
Exploring the Paradox of COVID-19 in Neurological Complications with Emphasis on Parkinson's and Alzheimer's Disease.Oxidative medicine and cellular longevity, , Volume: 2022, 2022
Plasma total tau predicts executive dysfunction in Parkinson's disease.Acta neurologica Scandinavica, , Volume: 145, Issue:1, 2022
Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups.Brain : a journal of neurology, , 06-03, Volume: 145, Issue:5, 2022
Queuine, a bacterial-derived hypermodified nucleobase, shows protection in in vitro models of neurodegeneration.PloS one, , Volume: 16, Issue:8, 2021
Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer's Disease.Medicina (Kaunas, Lithuania), , Sep-10, Volume: 57, Issue:9, 2021
Ultrasensitive techniques and protein misfolding amplification assays for biomarker-guided reconceptualization of Alzheimer's and other neurodegenerative diseases.Expert review of neurotherapeutics, , Volume: 21, Issue:9, 2021
Alternative platelet activation pathways and their role in neurodegenerative diseases.Neurobiology of disease, , Volume: 159, 2021
STochastic Optical Reconstruction Microscopy (STORM) reveals the nanoscale organization of pathological aggregates in human brain.Neuropathology and applied neurobiology, , Volume: 47, Issue:1, 2021
Microglia is associated with p-Tau aggregates in the olfactory bulb of patients with neurodegenerative diseases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 42, Issue:4, 2021
Novel blood test for early biomarkers of preeclampsia and Alzheimer's disease.Scientific reports, , 08-05, Volume: 11, Issue:1, 2021
Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer's continuum.Alzheimer's research & therapy, , 08-05, Volume: 13, Issue:1, 2021
Neurogranin as a Novel Biomarker in Alzheimer's Disease.Laboratory medicine, , Mar-15, Volume: 52, Issue:2, 2021
Sildenafil ameliorates Alzheimer disease via the modulation of vascular endothelial growth factor and vascular cell adhesion molecule-1 in rats.Human & experimental toxicology, , Volume: 40, Issue:4, 2021
α-Synuclein modulates tau spreading in mouse brains.The Journal of experimental medicine, , 01-04, Volume: 218, Issue:1, 2021
Clinicopathological investigation of the background of cognitive decline in elderly schizophrenia.Acta neuropsychiatrica, , Volume: 33, Issue:2, 2021
Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model.Molecular neurodegeneration, , 09-09, Volume: 16, Issue:1, 2021
Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease.Nature chemical biology, , Volume: 17, Issue:3, 2021
Interplay between tau and α-synuclein liquid-liquid phase separation.Protein science : a publication of the Protein Society, , Volume: 30, Issue:7, 2021
Inflammation and Parkinson's disease pathogenesis: Mechanisms and therapeutic insight.Progress in molecular biology and translational science, , Volume: 177, 2021
The Association Between Plasma α-Synuclein (α-syn) Protein, Urinary Alzheimer-Associated Neuronal Thread Protein (AD7c-NTP), and Apolipoprotein Epsilon 4 (ApoE ε4) Alleles and Cognitive Decline in 60 Patients with Alzheimer's Disease Compared with 28 Age-Medical science monitor : international medical journal of experimental and clinical research, , Jul-27, Volume: 27, 2021
Different patterns of hippocampal subfield pathology in Lewy body disease and Alzheimer's disease.Neuropathology and applied neurobiology, , Volume: 47, Issue:5, 2021
How gut microbes could drive brain disorders.Nature, , Volume: 590, Issue:7844, 2021
Prion Diseases: A Unique Transmissible Agent or a Model for Neurodegenerative Diseases?Biomolecules, , 02-02, Volume: 11, Issue:2, 2021
Lewy Body Pathology: From Amyloidosis to Vesicle Trafficking.Protein and peptide letters, , Volume: 28, Issue:11, 2021
Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.Chemical reviews, , 02-24, Volume: 121, Issue:4, 2021
Electrochemical biosensors for biometal-protein interactions in neurodegenerative diseases.Biosensors & bioelectronics, , May-01, Volume: 179, 2021
α-Synuclein Heteromers in Red Blood Cells of Alzheimer's Disease and Lewy Body Dementia Patients.Journal of Alzheimer's disease : JAD, , Volume: 80, Issue:2, 2021
Bispecific Tau Antibodies with Additional Binding to C1q or Alpha-Synuclein.Journal of Alzheimer's disease : JAD, , Volume: 80, Issue:2, 2021
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture.Nature genetics, , Volume: 53, Issue:3, 2021
Ecto-GPR37: a potential biomarker for Parkinson's disease.Translational neurodegeneration, , 02-26, Volume: 10, Issue:1, 2021
Multiple Neurodegenerative Pathologies in an Alzheimer's Disease Patient Treated with Fornical Deep Brain Stimulation.Journal of Alzheimer's disease : JAD, , Volume: 80, Issue:4, 2021
Disrupted metabolic connectivity in dopaminergic and cholinergic networks at different stages of dementia from Scientific reports, , 03-08, Volume: 11, Issue:1, 2021
Clinicopathological correlations and cholinesterase expression in early-onset familial Alzheimer's disease with the presenilin 1 mutation, Leu235Pro.Neurobiology of aging, , Volume: 103, 2021
Amyloid Structural Changes Studied by Infrared Microspectroscopy in Bigenic Cellular Models of Alzheimer's Disease.International journal of molecular sciences, , Mar-26, Volume: 22, Issue:7, 2021
In Vivo Diagnosis of Synucleinopathies: A Comparative Study of Skin Biopsy and RT-QuIC.Neurology, , 05-18, Volume: 96, Issue:20, 2021
Nanoaggregates Derived from Amyloid-beta and Alpha-synuclein Characterized by Sequential Quadruple Force Mapping.Nano letters, , 05-12, Volume: 21, Issue:9, 2021
Molecular Factors Mediating Neural Cell Plasticity Changes in Dementia Brain Diseases.Neural plasticity, , Volume: 2021, 2021
Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer's Disease.Neurochemical research, , Volume: 46, Issue:7, 2021
Curcumin: A small molecule with big functionality against amyloid aggregation in neurodegenerative diseases and type 2 diabetes.BioFactors (Oxford, England), , Volume: 47, Issue:4, 2021
Associations of Neuropsychiatric Features with Cerebrospinal Fluid Biomarkers of Amyloidogenesis and Neurodegeneration in Dementia with Lewy Bodies Compared with Alzheimer's Disease and Cognitively Healthy People.Journal of Alzheimer's disease : JAD, , Volume: 81, Issue:3, 2021
Faster disease progression in Parkinson's disease with type 2 diabetes is not associated with increased α-synuclein, tau, amyloid-β or vascular pathology.Neuropathology and applied neurobiology, , Volume: 47, Issue:7, 2021
Cerebrospinal fluid α synuclein concentrations in patients with positive AD biomarkers and extrapyramidal symptoms.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 128, Issue:6, 2021
[The role of aluminum and lead in the development of Alzheimer's and Parkinson's diseases].Arkhiv patologii, , Volume: 83, Issue:3, 2021
Four Common Late-Life Cognitive Trajectories Patterns Associate with Replicable Underlying Neuropathologies.Journal of Alzheimer's disease : JAD, , Volume: 82, Issue:2, 2021
Proteolytic α-Synuclein Cleavage in Health and Disease.International journal of molecular sciences, , May-21, Volume: 22, Issue:11, 2021
How an Infection of Sheep Revealed Prion Mechanisms in Alzheimer's Disease and Other Neurodegenerative Disorders.International journal of molecular sciences, , May-04, Volume: 22, Issue:9, 2021
Green Tea Epigallocatechin-3-gallate (EGCG) Targeting Protein Misfolding in Drug Discovery for Neurodegenerative Diseases.Biomolecules, , 05-20, Volume: 11, Issue:5, 2021
Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates.Journal of neuroinflammation, , Jun-03, Volume: 18, Issue:1, 2021
Biomarkers for neurodegenerative diseases.Nature medicine, , Volume: 27, Issue:6, 2021
New strategies for fluorescently labeling proteins in the study of amyloids.Current opinion in chemical biology, , Volume: 64, 2021
From Kuru to Alzheimer: A personal outlook.Protein science : a publication of the Protein Society, , Volume: 30, Issue:9, 2021
Slow-wave sleep affects synucleinopathy and regulates proteostatic processes in mouse models of Parkinson's disease.Science translational medicine, , 12-08, Volume: 13, Issue:623, 2021
Human amyloid beta and α-synuclein co-expression in neurons impair behavior and recapitulate features for Lewy body dementia in Caenorhabditis elegans.Biochimica et biophysica acta. Molecular basis of disease, , 10-01, Volume: 1867, Issue:10, 2021
Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions.Acta neuropathologica communications, , 07-21, Volume: 9, Issue:1, 2021
Mechanistic roles for altered O-GlcNAcylation in neurodegenerative disorders.The Biochemical journal, , 07-30, Volume: 478, Issue:14, 2021
Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies.Acta neuropathologica communications, , 08-28, Volume: 9, Issue:1, 2021
Modulating α-Synuclein Liquid-Liquid Phase Separation.Biochemistry, , 12-07, Volume: 60, Issue:48, 2021
Structural and Functional Insights into α-Synuclein Fibril Polymorphism.Biomolecules, , 09-28, Volume: 11, Issue:10, 2021
Biomarkers of neurodegeneration and glial activation validated in Alzheimer's disease assessed in longitudinal cerebrospinal fluid samples of Parkinson's disease.PloS one, , Volume: 16, Issue:10, 2021
Choroid plexus volume is associated with levels of CSF proteins: relevance for Alzheimer's and Parkinson's disease.Neurobiology of aging, , Volume: 89, 2020
APOENature reviews. Neurology, , Volume: 16, Issue:4, 2020
Systematic review of gene expression studies in people with Lewy body dementia.Acta neuropsychiatrica, , Volume: 32, Issue:6, 2020
Aggregation and Cellular Toxicity of Pathogenic or Non-pathogenic Proteins.Scientific reports, , 03-20, Volume: 10, Issue:1, 2020
Protein transmission in neurodegenerative disease.Nature reviews. Neurology, , Volume: 16, Issue:4, 2020
Role of Alcohol Drinking in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis.International journal of molecular sciences, , Mar-27, Volume: 21, Issue:7, 2020
The value of cerebrospinal fluid α-synuclein and the tau/α-synuclein ratio for diagnosis of neurodegenerative disorders with Lewy pathology.European journal of neurology, , Volume: 27, Issue:1, 2020
Novel biomarkers for the evaluation of aging-induced proteinopathies.Biogerontology, , Volume: 21, Issue:5, 2020
Degree of genetic liability for Alzheimer's disease associated with specific proteomic profiles in cerebrospinal fluid.Neurobiology of aging, , Volume: 93, 2020
Contribution of mixed pathology to medial temporal lobe atrophy in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 16, Issue:6, 2020
Small vessel disease pathological changes in neurodegenerative and vascular dementias concomitant with autonomic dysfunction.Brain pathology (Zurich, Switzerland), , Volume: 30, Issue:1, 2020
Calbindin-DCellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , May-02, Volume: 54, Issue:3, 2020
A new tetra-plex fluorimetric assay for the quantification of cerebrospinal fluid β-amyloid42, total-tau, phospho-tau and α-synuclein in the differential diagnosis of neurodegenerative dementia.Journal of neurology, , Volume: 267, Issue:9, 2020
Interactions between Soluble Species of β-Amyloid and α-Synuclein Promote Oligomerization while Inhibiting Fibrillization.Biochemistry, , 02-04, Volume: 59, Issue:4, 2020
Ubiquitin biology in neurodegenerative disorders: From impairment to therapeutic strategies.Ageing research reviews, , Volume: 61, 2020
Prodromal Intestinal Events in Alzheimer's Disease (AD): Colonic Dysmotility and Inflammation Are Associated with Enteric AD-Related Protein Deposition.International journal of molecular sciences, , May-15, Volume: 21, Issue:10, 2020
Biophysical studies of protein misfolding and aggregation in Quarterly reviews of biophysics, , 06-04, Volume: 49, 2020
Application of yeast to studying amyloid and prion diseases.Advances in genetics, , Volume: 105, 2020
Dual Targeting of Monomeric Tau and α-Synuclein Aggregation: A New Multitarget Therapeutic Strategy for Neurodegeneration.ACS chemical neuroscience, , 07-15, Volume: 11, Issue:14, 2020
General Aggregation-Induced Emission Probes for Amyloid Inhibitors with Dual Inhibition Capacity against Amyloid β-Protein and α-Synuclein.ACS applied materials & interfaces, , Jul-15, Volume: 12, Issue:28, 2020
Systematic review of genetic association studies in people with Lewy body dementia.International journal of geriatric psychiatry, , Volume: 35, Issue:5, 2020
CSF total tau/α-synuclein ratio improved the diagnostic performance for Alzheimer's disease as an indicator of tau phosphorylation.Alzheimer's research & therapy, , 07-13, Volume: 12, Issue:1, 2020
Prolongation of metallothionein induction combats Aß and α-synuclein toxicity in aged transgenic Caenorhabditis elegans.Scientific reports, , 07-16, Volume: 10, Issue:1, 2020
Somatic mutations in neurodegeneration: An update.Neurobiology of disease, , Volume: 144, 2020
Novel Therapeutics for the Treatment of Alzheimer's and Parkinson's Disease.Current pharmaceutical design, , Volume: 26, Issue:7, 2020
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.Scientific reports, , 07-30, Volume: 10, Issue:1, 2020
Aβ Puts the Alpha in Synuclein.Neuron, , 01-22, Volume: 105, Issue:2, 2020
Discoidin Domain Receptor 1 is a therapeutic target for neurodegenerative diseases.Human molecular genetics, , 10-10, Volume: 29, Issue:17, 2020
Immunotherapy for Parkinson's disease.Neurobiology of disease, , Volume: 137, 2020
Potential Role of Natural Polyphenols against Protein Aggregation Toxicity: In Vitro, In Vivo, and Clinical Studies.ACS chemical neuroscience, , 10-07, Volume: 11, Issue:19, 2020
Mangosteen Pericarp and Its Bioactive Xanthones: Potential Therapeutic Value in Alzheimer's Disease, Parkinson's Disease, and Depression with Pharmacokinetic and Safety Profiles.International journal of molecular sciences, , Aug-27, Volume: 21, Issue:17, 2020
Quadruple abnormal protein aggregates in brainstem pathology and exogenous metal-rich magnetic nanoparticles (and engineered Ti-rich nanorods). The substantia nigrae is a very early target in young urbanites and the gastrointestinal tract a key brainstem Environmental research, , Volume: 191, 2020
Hippocampal subfield pathologic burden in Lewy body diseases vs. Alzheimer's disease.Neuropathology and applied neurobiology, , Volume: 46, Issue:7, 2020
Association of APOE e2 genotype with Alzheimer's and non-Alzheimer's neurodegenerative pathologies.Nature communications, , 09-18, Volume: 11, Issue:1, 2020
Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro.Molecules (Basel, Switzerland), , Jan-29, Volume: 25, Issue:3, 2020
Associations of sleep characteristics with alpha-synuclein in cerebrospinal fluid in older adults.Annals of clinical and translational neurology, , Volume: 7, Issue:10, 2020
Differential diagnostic value of total alpha-synuclein assay in the cerebrospinal fluid between Alzheimer's disease and dementia with Lewy bodies from the prodromal stage.Alzheimer's research & therapy, , 09-29, Volume: 12, Issue:1, 2020
Microglia modulate neurodegeneration in Alzheimer's and Parkinson's diseases.Science (New York, N.Y.), , 10-02, Volume: 370, Issue:6512, 2020
Mixed Brain Pathology Is the Most Common Cause of Cognitive Impairment in the Elderly.Journal of Alzheimer's disease : JAD, , Volume: 78, Issue:1, 2020
Rapid Structural, Kinetic, and Immunochemical Analysis of Alpha-Synuclein Oligomers in Solution.Nano letters, , 11-11, Volume: 20, Issue:11, 2020
Multiplicity of α-Synuclein Aggregated Species and Their Possible Roles in Disease.International journal of molecular sciences, , Oct-28, Volume: 21, Issue:21, 2020
Spearmint Extract Containing Rosmarinic Acid Suppresses Amyloid Fibril Formation of Proteins Associated with Dementia.Nutrients, , Nov-13, Volume: 12, Issue:11, 2020
Complex Interaction between Resident Microbiota and Misfolded Proteins: Role in Neuroinflammation and Neurodegeneration.Cells, , 11-13, Volume: 9, Issue:11, 2020
Effect of Ionic Strength on Thioflavin-T Affinity to Amyloid Fibrils and Its Fluorescence Intensity.International journal of molecular sciences, , Nov-24, Volume: 21, Issue:23, 2020
Evaluating the Effects of Grain of Isogenic Wheat Lines Differing in the Content of Anthocyanins in Mouse Models of Neurodegenerative Disorders.Nutrients, , Dec-18, Volume: 12, Issue:12, 2020
PET Radiopharmaceuticals for Alzheimer's Disease and Parkinson's Disease Diagnosis, the Current and Future Landscape.Molecules (Basel, Switzerland), , Feb-21, Volume: 25, Issue:4, 2020
Synthesis and characterization of high affinity fluorogenic α-synuclein probes.Chemical communications (Cambridge, England), , Mar-24, Volume: 56, Issue:24, 2020
KDS2010: A Potent Highly Selective and Reversible MAO-B Inhibitor for Alzheimer's Disease.Combinatorial chemistry & high throughput screening, , Volume: 23, Issue:9, 2020
CSF or serum neurofilament light added to α-Synuclein panel discriminates Parkinson's from controls.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:2, 2020
Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes.Nature neuroscience, , Volume: 22, Issue:7, 2019
Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer's and Parkinson disease pathology.Biochimica et biophysica acta. Molecular basis of disease, , 08-01, Volume: 1865, Issue:8, 2019
Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration.Brain pathology (Zurich, Switzerland), , Volume: 29, Issue:1, 2019
The Toxicity of Misfolded Protein Oligomers Is Independent of Their Secondary Structure.ACS chemical biology, , 07-19, Volume: 14, Issue:7, 2019
Investigating the Association Between Verbal Forgetting and Pathological Markers of Alzheimer's and Lewy Body Diseases.Journal of Alzheimer's disease : JAD, , Volume: 70, Issue:3, 2019
Roles for the adaptive immune system in Parkinson's and Alzheimer's diseases.Current opinion in immunology, , Volume: 59, 2019
Effects of single and combined immunotherapy approach targeting amyloid β protein and α-synuclein in a dementia with Lewy bodies-like model.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 15, Issue:9, 2019
Twendee X Ameliorates Phosphorylated Tau, α-Synuclein and Neurovascular Dysfunction in Alzheimer's Disease Transgenic Mice With Chronic Cerebral Hypoperfusion.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, , Volume: 28, Issue:10, 2019
AD biomarkers at AAIC 2019.Nature reviews. Neurology, , Volume: 15, Issue:9, 2019
Measurement of CSF α-synuclein improves early differential diagnosis of mild cognitive impairment due to Alzheimer's disease.Journal of neurochemistry, , Volume: 150, Issue:2, 2019
High lithium levels in tobacco may account for reduced incidences of both Parkinson's disease and melanoma in smokers through enhanced β-catenin-mediated activity.Medical hypotheses, , Volume: 131, 2019
LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?Biochemical Society transactions, , 06-28, Volume: 47, Issue:3, 2019
Transcriptomics in tissue glucocorticoid sensitivity.European journal of clinical investigation, , Volume: 49, Issue:8, 2019
Heterogeneity in α-synuclein subtypes and their expression in cortical brain tissue lysates from Lewy body diseases and Alzheimer's disease.Neuropathology and applied neurobiology, , Volume: 45, Issue:6, 2019
Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 15, Issue:1, 2019
α-synuclein in the pathophysiology of Alzheimer's disease.Molecular neurodegeneration, , 06-11, Volume: 14, Issue:1, 2019
Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression.Acta neuropathologica communications, , 09-02, Volume: 7, Issue:1, 2019
Erythrocytes as Biomarkers for Dementia: Analysis of Protein Content and Alpha-Synuclein.Journal of Alzheimer's disease : JAD, , 08-12, Volume: 71, Issue:2, 2019
Dementia with lewy bodies: GBA1 mutations are associated with cerebrospinal fluid alpha-synuclein profile.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:7, 2019
Lower nucleus accumbens α-synuclein load and D3 receptor levels in Parkinson's disease with impulsive compulsive behaviours.Brain : a journal of neurology, , 11-01, Volume: 142, Issue:11, 2019
Late-Life Depression and Lewy Body Disease.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, , Volume: 27, Issue:3, 2019
Associations Between APOE Variants, Tau and α-Synuclein.Advances in experimental medicine and biology, , Volume: 1184, 2019
Ultrasensitive Detection of Aggregated α-Synuclein in Glial Cells, Human Cerebrospinal Fluid, and Brain Tissue Using the RT-QuIC Assay: New High-Throughput Neuroimmune Biomarker Assay for Parkinsonian Disorders.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 14, Issue:3, 2019
Potential Diagnostic Value of Red Blood Cells α-Synuclein Heteroaggregates in Alzheimer's Disease.Molecular neurobiology, , Volume: 56, Issue:9, 2019
An attempt to elucidate the role of iron and zinc ions in development of Alzheimer's and Parkinson's diseases.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 111, 2019
Aβ, Tau, and α-Synuclein aggregation and integrated role of PARK2 in the regulation and clearance of toxic peptides.Neuropeptides, , Volume: 78, 2019
A Genome-Wide Association Study of α-Synuclein Levels in Cerebrospinal Fluid.Neurotoxicity research, , Volume: 35, Issue:1, 2019
Simultaneous quantification of tau and α-synuclein in cerebrospinal fluid by high-resolution mass spectrometry for differentiation of Lewy Body Dementia from Alzheimer's Disease and controls.The Analyst, , Oct-22, Volume: 144, Issue:21, 2019
The prion-like propagation hypothesis in Alzheimer's and Parkinson's disease.Current opinion in neurology, , Volume: 32, Issue:2, 2019
Alzheimer's disease and other neurodegenerative dementias in comorbidity: A clinical and neuropathological overview.Clinical biochemistry, , Volume: 73, 2019
rAAV-based brain slice culture models of Alzheimer's and Parkinson's disease inclusion pathologies.The Journal of experimental medicine, , 03-04, Volume: 216, Issue:3, 2019
Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases.Neurology, , 02-12, Volume: 92, Issue:7, 2019
Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders.Annals of neurology, , Volume: 85, Issue:2, 2019
The toxin MPTP generates similar cognitive and locomotor deficits in hTau and tau knock-out mice.Brain research, , 05-15, Volume: 1711, 2019
Million-fold sensitivity enhancement in proteopathic seed amplification assays for biospecimens by Hofmeister ion comparisons.Proceedings of the National Academy of Sciences of the United States of America, , 11-12, Volume: 116, Issue:46, 2019
Redox active metals in neurodegenerative diseases.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, , Volume: 24, Issue:8, 2019
Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies.Cells, , 10-10, Volume: 8, Issue:10, 2019
[The Propagation Hypothesis of Prion-like Protein Agregates in Neurodegenerative Diseases].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 71, Issue:11, 2019
α-Synuclein RT-QuIC assay in cerebrospinal fluid of patients with dementia with Lewy bodies.Annals of clinical and translational neurology, , Volume: 6, Issue:10, 2019
Differential diagnosis between Alzheimer's disease and other dementias: Role of cerebrospinal fluid biomarkers.Clinical biochemistry, , Volume: 72, 2019
Metal ions and degenerative diseases.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, , Volume: 24, Issue:8, 2019
Parkinson's disease and Alzheimer's disease: a Mendelian randomization study.BMC medical genetics, , 12-31, Volume: 19, Issue:Suppl 1, 2018
Distinct functional roles of Vps41-mediated neuroprotection in Alzheimer's and Parkinson's disease models of neurodegeneration.Human molecular genetics, , 12-15, Volume: 27, Issue:24, 2018
Methylation changes and aberrant expression of FGFR3 in Lewy body disease neurons.Brain research, , 10-15, Volume: 1697, 2018
Insights into the Molecular Mechanisms of Alzheimer's and Parkinson's Diseases with Molecular Simulations: Understanding the Roles of Artificial and Pathological Missense Mutations in Intrinsically Disordered Proteins Related to Pathology.International journal of molecular sciences, , Jan-24, Volume: 19, Issue:2, 2018
Relationships between lewy and tau pathologies in 375 consecutive non-Alzheimer's olfactory bulbs.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:2, 2018
Autopsied centenarian case of Alzheimer's disease combined with hippocampal sclerosis, TDP-43, and α-synuclein pathologies.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 38, Issue:6, 2018
A refined concept: α-synuclein dysregulation disease.Neurochemistry international, , Volume: 119, 2018
Diagnostic value of cerebrospinal fluid alpha-synuclein in dementia with Lewy body.Geriatrie et psychologie neuropsychiatrie du vieillissement, , Sep-01, Volume: 16, Issue:3, 2018
The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration.FEBS letters, , Volume: 592, Issue:23, 2018
Neuropsychiatric symptoms and α-Synuclein profile of patients with Parkinson's disease dementia, dementia with Lewy bodies and Alzheimer's disease.Journal of neurology, , Volume: 265, Issue:10, 2018
A Longitudinal Study of Total and Phosphorylated α-Synuclein with Other Biomarkers in Cerebrospinal Fluid of Alzheimer's Disease and Mild Cognitive Impairment.Journal of Alzheimer's disease : JAD, , Volume: 61, Issue:4, 2018
α-Synuclein species as potential cerebrospinal fluid biomarkers for dementia with lewy bodies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:11, 2018
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells.Chembiochem : a European journal of chemical biology, , 10-04, Volume: 19, Issue:19, 2018
Synergistic Amyloid Switch Triggered by Early Heterotypic Oligomerization of Intrinsically Disordered α-Synuclein and Tau.Journal of molecular biology, , 08-03, Volume: 430, Issue:16, 2018
Bidirectional modulation of Alzheimer phenotype by alpha-synuclein in mice and primary neurons.Acta neuropathologica, , Volume: 136, Issue:4, 2018
Endogenous Murine Amyloid-β Peptide Assembles into Aggregates in the Aged C57BL/6J Mouse Suggesting These Animals as a Model to Study Pathogenesis of Amyloid-β Plaque Formation.Journal of Alzheimer's disease : JAD, , Volume: 61, Issue:4, 2018
Improving the identification of dementia with Lewy bodies in the context of an Alzheimer's-type dementia.Alzheimer's research & therapy, , 03-01, Volume: 10, Issue:1, 2018
Alternative hypotheses related to Alzheimer's disease.Bratislavske lekarske listy, , Volume: 119, Issue:4, 2018
Lewy Body Dementia.Clinics in geriatric medicine, , Volume: 34, Issue:4, 2018
Negative 11C-PIB PET Predicts Lack of Alzheimer's Disease Pathology in Postmortem Examination.Journal of Alzheimer's disease : JAD, , Volume: 63, Issue:1, 2018
Novel monoclonal antibodies targeting the microtubule-binding domain of human tau.PloS one, , Volume: 13, Issue:4, 2018
Lack of pathogenic potential of peripheral α-synuclein aggregates from Parkinson's disease patients.Acta neuropathologica communications, , 02-08, Volume: 6, Issue:1, 2018
Shedding light on aberrant interactions - a review of modern tools for studying protein aggregates.The FEBS journal, , Volume: 285, Issue:19, 2018
Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 14, Issue:8, 2018
Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated.Brain : a journal of neurology, , 07-01, Volume: 141, Issue:7, 2018
Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC.Acta neuropathologica communications, , 02-09, Volume: 6, Issue:1, 2018
Alzheimer disease biomarkers and synucleinopathy.Neurology, , 03-20, Volume: 90, Issue:12, 2018
Long Road to Ruin: Noradrenergic Dysfunction in Neurodegenerative Disease.Trends in neurosciences, , Volume: 41, Issue:4, 2018
Possible Role of the Polyglutamine Elongation in Evolution of Amyloid-Related Evolvability.Journal of Huntington's disease, , Volume: 7, Issue:4, 2018
Associations between ZnT3, tau pathology, agitation, and delusions in dementia.International journal of geriatric psychiatry, , Volume: 33, Issue:8, 2018
Alzheimer's disease and alpha-synuclein pathology in the olfactory bulbs of infants, children, teens and adults ≤ 40 years in Metropolitan Mexico City. APOE4 carriers at higher risk of suicide accelerate their olfactory bulb pathology.Environmental research, , Volume: 166, 2018
The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease.Acta neuropathologica communications, , 11-26, Volume: 6, Issue:1, 2018
Sex differences in Alzheimer's disease and common neuropathologies of aging.Acta neuropathologica, , Volume: 136, Issue:6, 2018
Cerebral inoculation of human A53T α-synuclein reduces spatial memory decline and amyloid-β aggregation in APP/PS1 transgenic mice of Alzheimer's disease.Brain research bulletin, , Volume: 143, 2018
Analysis of age-related changes in psychosine metabolism in the human brain.PloS one, , Volume: 13, Issue:2, 2018
Quinolinic Acid Amyloid-like Fibrillar Assemblies Seed α-Synuclein Aggregation.Journal of molecular biology, , 10-12, Volume: 430, Issue:20, 2018
Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases.The FEBS journal, , Volume: 285, Issue:19, 2018
Association of cerebrospinal fluid α-synuclein with total and phospho-tauAlzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 14, Issue:12, 2018
Beneficial Effects of Green Tea Catechins on Neurodegenerative Diseases.Molecules (Basel, Switzerland), , May-29, Volume: 23, Issue:6, 2018
Implications of Metal Binding and Asparagine Deamidation for Amyloid Formation.International journal of molecular sciences, , Aug-19, Volume: 19, Issue:8, 2018
Differential role of CSF fatty acid binding protein 3, α-synuclein, and Alzheimer's disease core biomarkers in Lewy body disorders and Alzheimer's dementia.Alzheimer's research & therapy, , Jul-28, Volume: 9, Issue:1, 2017
Physico-Pathologic Mechanisms Involved in Neurodegeneration: Misfolded Protein-Plasma Membrane Interactions.Neuron, , Jul-05, Volume: 95, Issue:1, 2017
Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer's disease.Scientific reports, , 01-10, Volume: 7, 2017
Neuronal Loss and Α-Synuclein Pathology in the Superior Colliculus and Its Relationship to Visual Hallucinations in Dementia with Lewy Bodies.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, , Volume: 25, Issue:6, 2017
A new potential biomarker for dementia with Lewy bodies: Skin nerve α-synuclein deposits.Neurology, , Jul-25, Volume: 89, Issue:4, 2017
A preclinical screen to evaluate pharmacotherapies for the treatment of agitation in dementia.Behavioural pharmacology, , Volume: 28, Issue:2 and 3-Sp, 2017
Human cyclophilin 40 unravels neurotoxic amyloids.PLoS biology, , Volume: 15, Issue:6, 2017
Vaccination strategies in tauopathies and synucleinopathies.Journal of neurochemistry, , Volume: 143, Issue:5, 2017
Modulation of Parkinson's Disease Associated Protein Rescues Alzheimer's Disease Degeneration.Journal of Alzheimer's disease : JAD, , Volume: 55, Issue:1, 2017
Dementia: Skin α-synuclein deposits - a new biomarker for DLB?Nature reviews. Neurology, , Volume: 13, Issue:9, 2017
Extracts from two ubiquitous Mediterranean plants ameliorate cellular and animal models of neurodegenerative proteinopathies.Neuroscience letters, , 01-18, Volume: 638, 2017
The Clinical Use of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease Diagnosis: The Italian Selfie.Journal of Alzheimer's disease : JAD, , Volume: 55, Issue:4, 2017
Protein aggregation and neurodegeneration in prototypical neurodegenerative diseases: Examples of amyloidopathies, tauopathies and synucleinopathies.Progress in neurobiology, , Volume: 155, 2017
Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology.Acta neuropathologica communications, , 06-09, Volume: 5, Issue:1, 2017
Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits.Proceedings of the National Academy of Sciences of the United States of America, , 06-06, Volume: 114, Issue:23, 2017
Quantitative neuropathology: an update on automated methodologies and implications for large scale cohorts.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 124, Issue:6, 2017
Higher levels of myelin phospholipids in brains of neuronal α-Synuclein transgenic mice precede myelin loss.Acta neuropathologica communications, , 05-08, Volume: 5, Issue:1, 2017
Amygdala α-Synuclein Pathology in the Population-Based Vantaa 85+ Study.Journal of Alzheimer's disease : JAD, , Volume: 58, Issue:3, 2017
Novel Benzothiazole Derivatives as Fluorescent Probes for Detection of β-Amyloid and α-Synuclein Aggregates.ACS chemical neuroscience, , 08-16, Volume: 8, Issue:8, 2017
Regional Overlap of Pathologies in Lewy Body Disorders.Journal of neuropathology and experimental neurology, , 03-01, Volume: 76, Issue:3, 2017
Changes in CD200 and intercellular adhesion molecule-1 (ICAM-1) levels in brains of Lewy body disorder cases are associated with amounts of Alzheimer's pathology not α-synuclein pathology.Neurobiology of aging, , Volume: 54, 2017
α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies.Nature medicine, , Feb-07, Volume: 23, Issue:2, 2017
Lack of spontaneous age-related brain pathology in Octodon degus: a reappraisal of the model.Scientific reports, , 04-04, Volume: 7, 2017
Synaptic phosphorylated α-synuclein in dementia with Lewy bodies.Brain : a journal of neurology, , Dec-01, Volume: 140, Issue:12, 2017
The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome.PloS one, , Volume: 12, Issue:9, 2017
Lysosomal dysfunction in the brain of a mouse model with intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein.Molecular psychiatry, , Volume: 22, Issue:7, 2017
MOAG-4 promotes the aggregation of α-synuclein by competing with self-protective electrostatic interactions.The Journal of biological chemistry, , 05-19, Volume: 292, Issue:20, 2017
Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders.Pharmacology & therapeutics, , Volume: 172, 2017
Small-molecule PET Tracers for Imaging Proteinopathies.Seminars in nuclear medicine, , Volume: 47, Issue:5, 2017
Discoidin domain receptor inhibition reduces neuropathology and attenuates inflammation in neurodegeneration models.Journal of neuroimmunology, , 10-15, Volume: 311, 2017
Evaluation of a DNA Aβ42 Vaccine in Aged NZW Rabbits: Antibody Kinetics and Immune Profile after Intradermal Immunization with Full-Length DNA Aβ42 Trimer.Journal of Alzheimer's disease : JAD, , Volume: 57, Issue:1, 2017
Synthesis and biological evaluation of novel radioiodinated benzimidazole derivatives for imaging α-synuclein aggregates.Bioorganic & medicinal chemistry, , 12-15, Volume: 25, Issue:24, 2017
Increased Transforming Growth Factor β2 in the Neocortex of Alzheimer's Disease and Dementia with Lewy Bodies is Correlated with Disease Severity and Soluble Aβ42 Load.Journal of Alzheimer's disease : JAD, , Volume: 56, Issue:1, 2017
Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis.The Lancet. Neurology, , Volume: 16, Issue:1, 2017
A meta-analysis and review examining a possible role for oxidative stress and singlet oxygen in diverse diseases.The Biochemical journal, , 08-02, Volume: 474, Issue:16, 2017
Analysis of primary visual cortex in dementia with Lewy bodies indicates GABAergic involvement associated with recurrent complex visual hallucinations.Acta neuropathologica communications, , 06-30, Volume: 4, Issue:1, 2016
Non-Amyloid-β Component of Human α-Synuclein Oligomers Induces Formation of New Aβ Oligomers: Insight into the Mechanisms That Link Parkinson's and Alzheimer's Diseases.ACS chemical neuroscience, , Jan-20, Volume: 7, Issue:1, 2016
Cell Models to Study Cell-to-Cell Transmission of α-Synuclein.Methods in molecular biology (Clifton, N.J.), , Volume: 1345, 2016
Alpha-, Beta-, and Gamma-synuclein Quantification in Cerebrospinal Fluid by Multiple Reaction Monitoring Reveals Increased Concentrations in Alzheimer's and Creutzfeldt-Jakob Disease but No Alteration in Synucleinopathies.Molecular & cellular proteomics : MCP, , Volume: 15, Issue:10, 2016
Detection of Helical Intermediates During Amyloid Formation by Intrinsically Disordered Polypeptides and Proteins.Methods in molecular biology (Clifton, N.J.), , Volume: 1345, 2016
Subgroup differences in 'brain-type' transferrin and α-synuclein in Parkinson's disease and multiple system atrophy.Journal of biochemistry, , Volume: 160, Issue:2, 2016
Oligomeric α-synuclein and β-amyloid variants as potential biomarkers for Parkinson's and Alzheimer's diseases.The European journal of neuroscience, , Volume: 43, Issue:1, 2016
A First Tetraplex Assay for the Simultaneous Quantification of Total α-Synuclein, Tau, β-Amyloid42 and DJ-1 in Human Cerebrospinal Fluid.PloS one, , Volume: 11, Issue:4, 2016
Coordination and redox properties of copper interaction with α-synuclein.Journal of inorganic biochemistry, , Volume: 163, 2016
Unfolded protein response is activated in Lewy body dementias.Neuropathology and applied neurobiology, , Volume: 42, Issue:4, 2016
[A Therapeutic Target for Inhibition of Neurodegeneration: Autophagy].Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova, , Volume: 66, Issue:5, 2016
Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 07-27, Volume: 36, Issue:30, 2016
Aged Lewis rats exposed to low and moderate doses of rotenone are a good model for studying the process of protein aggregation and its effects upon central nervous system cell physiology.Arquivos de neuro-psiquiatria, , Volume: 74, Issue:9, 2016
Brain Atrophy of Secondary REM-Sleep Behavior Disorder in Neurodegenerative Disease.Journal of Alzheimer's disease : JAD, , 04-05, Volume: 52, Issue:3, 2016
Glycation in Parkinson's disease and Alzheimer's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:6, 2016
Oligomeropathies and pathogenesis of Alzheimer and Parkinson's diseases.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:6, 2016
Cerebrospinal Fluid Biomarkers in Highly Exposed PM2.5 Urbanites: The Risk of Alzheimer's and Parkinson's Diseases in Young Mexico City Residents.Journal of Alzheimer's disease : JAD, , 09-06, Volume: 54, Issue:2, 2016
Elevated mRNA Expression and Low Methylation of SNCA in Japanese Alzheimer's Disease Subjects.Journal of Alzheimer's disease : JAD, , 10-18, Volume: 54, Issue:4, 2016
Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons.Proceedings of the National Academy of Sciences of the United States of America, , Apr-05, Volume: 113, Issue:14, 2016
Potential Pathways of Abnormal Tau and α-Synuclein Dissemination in Sporadic Alzheimer's and Parkinson's Diseases.Cold Spring Harbor perspectives in biology, , Nov-01, Volume: 8, Issue:11, 2016
TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau.eLife, , 10-25, Volume: 5, 2016
Pathogenic mechanisms of prion protein, amyloid-β and α-synuclein misfolding: the prion concept and neurotoxicity of protein oligomers.Journal of neurochemistry, , Volume: 139, Issue:2, 2016
Interactions Between α-Synuclein and Tau Protein: Implications to Neurodegenerative Disorders.Journal of molecular neuroscience : MN, , Volume: 60, Issue:3, 2016
The red-hot debate about transmissible Alzheimer's.Nature, , Mar-17, Volume: 531, Issue:7594, 2016
A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins.ACS combinatorial science, , Mar-14, Volume: 18, Issue:3, 2016
Altered Proteins in the Aging Brain.Journal of neuropathology and experimental neurology, , Volume: 75, Issue:4, 2016
Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer's and Parkinson's Disease.International journal of molecular sciences, , Feb-06, Volume: 17, Issue:2, 2016
TDP-43 in the olfactory bulb in Alzheimer's disease.Neuropathology and applied neurobiology, , Volume: 42, Issue:4, 2016
Lewy- and Alzheimer-type pathologies in midbrain and cerebellum across the Lewy body disorders spectrum.Neuropathology and applied neurobiology, , Volume: 42, Issue:5, 2016
Stabilization of α-Synuclein Fibril Clusters Prevents Fragmentation and Reduces Seeding Activity and Toxicity.Biochemistry, , Feb-02, Volume: 55, Issue:4, 2016
Editorial overview: Neurobiology of disease.Current opinion in neurobiology, , Volume: 36, 2016
Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson's disease.Molecular neurodegeneration, , Jan-19, Volume: 11, 2016
Altered Levels of Visinin-Like Protein 1 Correspond to Regional Neuronal Loss in Alzheimer Disease and Frontotemporal Lobar Degeneration.Journal of neuropathology and experimental neurology, , Volume: 75, Issue:2, 2016
Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology.Acta neuropathologica, , Volume: 131, Issue:3, 2016
The Anti-Amyloid-β Monoclonal Antibody 4G8 Recognizes a Generic Sequence-Independent Epitope Associated with α-Synuclein and Islet Amyloid Polypeptide Amyloid Fibrils.Journal of Alzheimer's disease : JAD, , Volume: 50, Issue:2, 2016
Broad neutralization of calcium-permeable amyloid pore channels with a chimeric Alzheimer/Parkinson peptide targeting brain gangliosides.Biochimica et biophysica acta, , Volume: 1862, Issue:2, 2016
A cytosine-thymine (CT)-rich haplotype in intron 4 of SNCA confers risk for Lewy body pathology in Alzheimer's disease and affects SNCA expression.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 11, Issue:10, 2015
Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth.Scientific reports, , May-28, Volume: 5, 2015
Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology.Neurobiology of disease, , Volume: 79, 2015
α-Synuclein pathology accumulates in sacral spinal visceral sensory pathways.Annals of neurology, , Volume: 78, Issue:1, 2015
Use of CSF α-synuclein in the differential diagnosis between Alzheimer's disease and other neurodegenerative disorders.International psychogeriatrics, , Volume: 27, Issue:9, 2015
Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways.BMC neuroscience, , Oct-23, Volume: 16, 2015
Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.Experimental & molecular medicine, , Mar-13, Volume: 47, 2015
Neuropathologically mixed Alzheimer's and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes.Acta neuropathologica, , Volume: 129, Issue:5, 2015
Patterns of Tau and α-Synuclein Pathology in the Visual System.Journal of Parkinson's disease, , Volume: 5, Issue:2, 2015
Intracellular screening of a peptide library to derive a potent peptide inhibitor of α-synuclein aggregation.The Journal of biological chemistry, , Mar-20, Volume: 290, Issue:12, 2015
Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap?Experimental gerontology, , Volume: 68, 2015
I716F AβPP mutation associates with the deposition of oligomeric pyroglutamate amyloid-β and α-synucleinopathy with Lewy bodies.Journal of Alzheimer's disease : JAD, , Volume: 44, Issue:1, 2015
Cerebrospinal fluid α-synuclein and Lewy body-like symptoms in normal controls, mild cognitive impairment, and Alzheimer's disease.Journal of Alzheimer's disease : JAD, , Volume: 43, Issue:3, 2015
Heroin abuse exaggerates age-related deposition of hyperphosphorylated tau and p62-positive inclusions.Neurobiology of aging, , Volume: 36, Issue:11, 2015
NEURODEGENERATION. Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein.Science (New York, N.Y.), , Aug-07, Volume: 349, Issue:6248, 2015
Opposing effects of APP/PS1 and TrkB.T1 genotypes on midbrain dopamine neurons and stimulated dopamine release in vivo.Brain research, , Oct-05, Volume: 1622, 2015
Quantification of CSF biomarkers using an electrochemiluminescence-based detection system in the differential diagnosis of AD and sCJD.Journal of neurology, , Volume: 262, Issue:10, 2015
Influence of Lentiviral β-Synuclein Overexpression in the Hippocampus of a Transgenic Mouse Model of Alzheimer's Disease on Amyloid Precursor Protein Metabolism and Pathology.Neuro-degenerative diseases, , Volume: 15, Issue:4, 2015
Early Stage of Progressive Supranuclear Palsy: A Neuropathological Study of 324 Consecutive Autopsy Cases.Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, , Volume: 82, Issue:6, 2015
Sensitive Detection of Proteopathic Seeding Activity with FRET Flow Cytometry.Journal of visualized experiments : JoVE, , Dec-08, Issue:106, 2015
[Histopathological and immunohistochemical study of spinal cord tissues in neurodegenerative diseases].Zhonghua bing li xue za zhi = Chinese journal of pathology, , Volume: 44, Issue:8, 2015
[Expression of proteins related neurodegeneration in autopsy brains of the aged].Zhonghua bing li xue za zhi = Chinese journal of pathology, , Volume: 43, Issue:10, 2014
Accumulation of α-synuclein in dementia with Lewy bodies is associated with decline in the α-synuclein-degrading enzymes kallikrein-6 and calpain-1.Acta neuropathologica communications, , Dec-05, Volume: 2, 2014
Monoclonal antibodies against Aβ42 fibrils distinguish multiple aggregation state polymorphisms in vitro and in Alzheimer disease brain.The Journal of biological chemistry, , Nov-14, Volume: 289, Issue:46, 2014
Protein misfolding and aggregation in Alzheimer's disease and type 2 diabetes mellitus.CNS & neurological disorders drug targets, , Volume: 13, Issue:7, 2014
Cross dimerization of amyloid-β and αsynuclein proteins in aqueous environment: a molecular dynamics simulations study.PloS one, , Volume: 9, Issue:9, 2014
Molecular inscription of environmental information into protein suprastructures: temperature effects on unit assembly of α-synuclein oligomers into polymorphic amyloid fibrils.The Biochemical journal, , Dec-01, Volume: 464, Issue:2, 2014
APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease.JAMA neurology, , Volume: 71, Issue:11, 2014
Biochemical assessment of precuneus and posterior cingulate gyrus in the context of brain aging and Alzheimer's disease.PloS one, , Volume: 9, Issue:8, 2014
Deciphering the glycolipid code of Alzheimer's and Parkinson's amyloid proteins allowed the creation of a universal ganglioside-binding peptide.PloS one, , Volume: 9, Issue:8, 2014
Amyloid-β oligomers as a template for secondary amyloidosis in Alzheimer's disease.Neurobiology of disease, , Volume: 71, 2014
Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies.Acta neuropathologica, , Volume: 128, Issue:5, 2014
Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques.Neurobiology of disease, , Volume: 71, 2014
Is there a risk of prion-like disease transmission by Alzheimer- or Parkinson-associated protein particles?Acta neuropathologica, , Volume: 128, Issue:4, 2014
Flow cytometry analysis of synaptosomes from post-mortem human brain reveals changes specific to Lewy body and Alzheimer's disease.Laboratory investigation; a journal of technical methods and pathology, , Volume: 94, Issue:10, 2014
Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies.Human molecular genetics, , Dec-01, Volume: 23, Issue:23, 2014
Beta-amyloid, phospho-tau and alpha-synuclein deposits similar to those in the brain are not identified in the eyes of Alzheimer's and Parkinson's disease patients.Brain pathology (Zurich, Switzerland), , Volume: 24, Issue:1, 2014
Convergence of pathology in dementia with Lewy bodies and Alzheimer's disease: a role for the novel interaction of alpha-synuclein and presenilin 1 in disease.Brain : a journal of neurology, , Volume: 137, Issue:Pt 7, 2014
Prions: generation and spread versus neurotoxicity.The Journal of biological chemistry, , Jul-18, Volume: 289, Issue:29, 2014
Prion-like properties of Tau protein: the importance of extracellular Tau as a therapeutic target.The Journal of biological chemistry, , Jul-18, Volume: 289, Issue:29, 2014
Mouse models for studying the formation and propagation of prions.The Journal of biological chemistry, , Jul-18, Volume: 289, Issue:29, 2014
The genetic contributions of SNCA and LRRK2 genes to Lewy Body pathology in Alzheimer's disease.Human molecular genetics, , Sep-15, Volume: 23, Issue:18, 2014
Psychotic Alzheimer's disease is associated with gender-specific tau phosphorylation abnormalities.Neurobiology of aging, , Volume: 35, Issue:9, 2014
Sphingosine kinases modulate the secretion of amyloid β precursor protein from SH-SY5Y neuroblastoma cells: the role of α-synuclein.Folia neuropathologica, , Volume: 52, Issue:1, 2014
Neuropathological investigation of hypocretin expression in brains of dementia with Lewy bodies.Neuroscience letters, , May-21, Volume: 569, 2014
Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo.Brain : a journal of neurology, , Volume: 137, Issue:Pt 5, 2014
A generic method for design of oligomer-specific antibodies.PloS one, , Volume: 9, Issue:3, 2014
Protein folding and misfolding in the neurodegenerative disorders: a review.Revue neurologique, , Volume: 170, Issue:3, 2014
Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD.Acta neuropathologica, , Volume: 127, Issue:4, 2014
Increased CSF α-synuclein levels in Alzheimer's disease: correlation with tau levels.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 10, Issue:5 Suppl, 2014
Predictive association of copper metabolism proteins with Alzheimer's disease and Parkinson's disease: a preliminary perspective.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, , Volume: 27, Issue:1, 2014
Increased amoeboid microglial density in the olfactory bulb of Parkinson's and Alzheimer's patients.Brain pathology (Zurich, Switzerland), , Volume: 24, Issue:2, 2014
Naturally occurring α-synuclein autoantibody levels are lower in patients with Parkinson disease.Neurology, , Jan-08, Volume: 80, Issue:2, 2013
Kinase-kinase interaction and modulation of tau phosphorylation.International review of cell and molecular biology, , Volume: 300, 2013
Low CSF levels of both α-synuclein and the α-synuclein cleaving enzyme neurosin in patients with synucleinopathy.PloS one, , Volume: 8, Issue:1, 2013
Tetrahydroxystilbene glucoside antagonizes age-related α-synuclein overexpression in the hippocampus of APP transgenic mouse model of Alzheimer's disease.Restorative neurology and neuroscience, , Volume: 31, Issue:1, 2013
Synthesis of the Alzheimer drug Posiphen into its primary metabolic products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their inhibition of amyloid precursor protein, α-Synuclein synthesis, interleukin-1β release, and cholinergiAnti-inflammatory & anti-allergy agents in medicinal chemistry, , Volume: 12, Issue:2, 2013
Early Alzheimer's and Parkinson's disease pathology in urban children: Friend versus Foe responses--it is time to face the evidence.BioMed research international, , Volume: 2013, 2013
Enteric alpha-synuclein expression is increased in Parkinson's disease but not Alzheimer's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:2, 2013
[Neurotoxicity of pesticides: its relationship with neurodegenerative diseases].Medecine sciences : M/S, , Volume: 29, Issue:3, 2013
Evaluation of potential infectivity of Alzheimer and Parkinson disease proteins in recipients of cadaver-derived human growth hormone.JAMA neurology, , Volume: 70, Issue:4, 2013
Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model.Autophagy, , Volume: 9, Issue:4, 2013
Prolyl oligopeptidase colocalizes with α-synuclein, β-amyloid, tau protein and astroglia in the post-mortem brain samples with Parkinson's and Alzheimer's diseases.Neuroscience, , Jul-09, Volume: 242, 2013
Effect of α-synuclein on amyloid β-induced toxicity: relevance to Lewy body variant of Alzheimer disease.Neurochemical research, , Volume: 38, Issue:4, 2013
α-Synuclein in cerebrospinal fluid of Alzheimer's disease and mild cognitive impairment.Journal of Alzheimer's disease : JAD, , Volume: 36, Issue:4, 2013
Parkinsonism, dementia and glucocerebrosidase mutations.Journal of neurology, , Volume: 260, Issue:5, 2013
Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.Molecular psychiatry, , Volume: 18, Issue:8, 2013
Small molecules interacting with α-synuclein: antiaggregating and cytoprotective properties.Amino acids, , Volume: 45, Issue:2, 2013
Altered serum IgG levels to α-synuclein in dementia with Lewy bodies and Alzheimer's disease.PloS one, , Volume: 8, Issue:5, 2013
CSF levels of the neuronal injury biomarker visinin-like protein-1 in Alzheimer's disease and dementia with Lewy bodies.Journal of neurochemistry, , Volume: 127, Issue:5, 2013
CSF α-synuclein improves diagnostic and prognostic performance of CSF tau and Aβ in Alzheimer's disease.Acta neuropathologica, , Volume: 126, Issue:5, 2013
Changes in amyloid-β and Tau in the cerebrospinal fluid of transgenic mice overexpressing amyloid precursor protein.Science translational medicine, , Jul-17, Volume: 5, Issue:194, 2013
The diagnostic utility of cerebrospinal fluid alpha-synuclein analysis in dementia with Lewy bodies - a systematic review and meta-analysis.Parkinsonism & related disorders, , Volume: 19, Issue:10, 2013
The role of α-synuclein in neurodegenerative diseases: from molecular pathways in disease to therapeutic approaches.Current Alzheimer research, , Volume: 10, Issue:6, 2013
Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies.Nature reviews. Neuroscience, , Volume: 14, Issue:9, 2013
Non-Alzheimer neurodegenerative pathologies and their combinations are more frequent than commonly believed in the elderly brain: a community-based autopsy series.Acta neuropathologica, , Volume: 126, Issue:3, 2013
Novel 5' untranslated region directed blockers of iron-regulatory protein-1 dependent amyloid precursor protein translation: implications for down syndrome and Alzheimer's disease.PloS one, , Volume: 8, Issue:7, 2013
Treatment implications of the altered cytokine-insulin axis in neurodegenerative disease.Biochemical pharmacology, , Oct-01, Volume: 86, Issue:7, 2013
Effects of baseline CSF α-synuclein on regional brain atrophy rates in healthy elders, mild cognitive impairment and Alzheimer's disease.PloS one, , Volume: 8, Issue:12, 2013
The diagnostic value of CSF α-synuclein in the differential diagnosis of dementia with Lewy bodies vs. normal subjects and patients with Alzheimer's disease.PloS one, , Volume: 8, Issue:11, 2013
Plasma homocysteine, Alzheimer and cerebrovascular pathology: a population-based autopsy study.Brain : a journal of neurology, , Volume: 136, Issue:Pt 9, 2013
Self-propagation of pathogenic protein aggregates in neurodegenerative diseases.Nature, , Sep-05, Volume: 501, Issue:7465, 2013
Impaired mitochondrial energy production and ABC transporter function-A crucial interconnection in dementing proteopathies of the brain.Mechanisms of ageing and development, , Volume: 134, Issue:10, 2013
[The role of extracellular α-synuclein in molecular mechanisms of cell death].Postepy higieny i medycyny doswiadczalnej (Online), , Nov-04, Volume: 67, 2013
Identification of the sites of tau hyperphosphorylation and activation of tau kinases in synucleinopathies and Alzheimer's diseases.PloS one, , Volume: 8, Issue:9, 2013
Personalized medicine strategies for managing patients with parkinsonism and cognitive deficits.Metabolism: clinical and experimental, , Volume: 62 Suppl 1, 2013
Alzheimer's disease-related lesions.Journal of Alzheimer's disease : JAD, , Volume: 33 Suppl 1, 2013
Neuropathologic analysis of Lewy-related α-synucleinopathy in olfactory mucosa.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 33, Issue:1, 2013
A proteomic analysis of MCLR-induced neurotoxicity: implications for Alzheimer's disease.Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 127, Issue:2, 2012
Soluble α-synuclein is a novel modulator of Alzheimer's disease pathophysiology.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jul-25, Volume: 32, Issue:30, 2012
Generic inhibition of amyloidogenic proteins by two naphthoquinone-tryptophan hybrid molecules.Proteins, , Volume: 80, Issue:8, 2012
Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias.Brain : a journal of neurology, , Volume: 135, Issue:Pt 12, 2012
Positive lysosomal modulation as a unique strategy to treat age-related protein accumulation diseases.Rejuvenation research, , Volume: 15, Issue:2, 2012
Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate.Scientific reports, , Volume: 2, 2012
Experimental inhibition of fibrillogenesis and neurotoxicity by amyloid-beta (Aβ) and other disease-related peptides/proteins by plant extracts and herbal compounds.Sub-cellular biochemistry, , Volume: 65, 2012
α-Synuclein mRNA and soluble α-synuclein protein levels in post-mortem brain from patients with Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease.Brain research, , Jun-12, Volume: 1459, 2012
Neuropathological investigation of the hypometabolic regions on positron emission tomography with [18F] fluorodeoxyglucose in patients with dementia with Lewy bodies.Journal of the neurological sciences, , Mar-15, Volume: 314, Issue:1-2, 2012
Recommendations to standardize preanalytical confounding factors in Alzheimer's and Parkinson's disease cerebrospinal fluid biomarkers: an update.Biomarkers in medicine, , Volume: 6, Issue:4, 2012
Interaction between pathogenic proteins in neurodegenerative disorders.Journal of cellular and molecular medicine, , Volume: 16, Issue:6, 2012
Amyloid generation and dysfunctional immunoproteasome activation with disease progression in animal model of familial Alzheimer's disease.Brain pathology (Zurich, Switzerland), , Volume: 22, Issue:5, 2012
Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research.PloS one, , Volume: 7, Issue:7, 2012
Altered CSF orexin and α-synuclein levels in dementia patients.Journal of Alzheimer's disease : JAD, , Volume: 29, Issue:1, 2012
Antibody 9D5 recognizes oligomeric pyroglutamate amyloid-β in a fraction of amyloid-β deposits in Alzheimer's disease without cross-reactivity with other protein aggregates.Journal of Alzheimer's disease : JAD, , Volume: 29, Issue:2, 2012
[The role of proteins in neurodegenerative disease].Postepy higieny i medycyny doswiadczalnej (Online), , Apr-16, Volume: 66, 2012
Oxidative stress in Alzheimer's and Parkinson's diseases: insights from the yeast Saccharomyces cerevisiae.Oxidative medicine and cellular longevity, , Volume: 2012, 2012
Selection of DNA aptamers that recognize α-synuclein oligomers using a competitive screening method.Analytical chemistry, , Jul-03, Volume: 84, Issue:13, 2012
An evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology.Journal of neurology, neurosurgery, and psychiatry, , Volume: 83, Issue:4, 2012
Pathologic evaluation of the supraoptic and paraventricular nuclei in dementia.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, , Volume: 39, Issue:2, 2012
[An 87-year-old women with the clinical diagnosis of dementia with Lewy bodies without α-synuclein deposition].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 64, Issue:5, 2012
GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology.Neurology, , Nov-06, Volume: 79, Issue:19, 2012
Autoantibodies against amyloid and glial-derived antigens are increased in serum and cerebrospinal fluid of Lewy body-associated dementias.Journal of Alzheimer's disease : JAD, , Volume: 26, Issue:1, 2011
Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?Brain : a journal of neurology, , Volume: 134, Issue:Pt 5, 2011
α-Synuclein expression selectively affects tumorigenesis in mice modeling Parkinson's disease.PloS one, , Volume: 6, Issue:5, 2011
Prevalence and pathology of dementia with Lewy bodies in the oldest old: a comparison with other dementing disorders.Dementia and geriatric cognitive disorders, , Volume: 31, Issue:4, 2011
Aberrant protein structure and diseases of the brain.Irish journal of medical science, , Volume: 180, Issue:1, 2011
Neuropathology underlying clinical variability in patients with synucleinopathies.Acta neuropathologica, , Volume: 122, Issue:2, 2011
Increased dopaminergic cells and protein aggregates in the olfactory bulb of patients with neurodegenerative disorders.Acta neuropathologica, , Volume: 122, Issue:1, 2011
Decreased α-synuclein serum levels in patients with Lewy body dementia compared to Alzheimer's disease patients and control subjects.Dementia and geriatric cognitive disorders, , Volume: 31, Issue:6, 2011
Toward the discovery of effective polycyclic inhibitors of alpha-synuclein amyloid assembly.The Journal of biological chemistry, , Sep-16, Volume: 286, Issue:37, 2011
Single-molecule atomic force microscopy force spectroscopy study of Aβ-40 interactions.Biochemistry, , Jun-14, Volume: 50, Issue:23, 2011
A deadly spread: cellular mechanisms of α-synuclein transfer.Cell death and differentiation, , Volume: 18, Issue:9, 2011
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein.The Journal of biological chemistry, , Sep-30, Volume: 286, Issue:39, 2011
Parkinson disease: PD biomarkers-use of α-synuclein reaches new levels.Nature reviews. Neurology, , May-10, Volume: 7, Issue:6, 2011
CSF amyloid-β peptides in neuropathologically diagnosed dementia with Lewy bodies and Alzheimer's disease.Journal of Alzheimer's disease : JAD, , Volume: 24, Issue:2, 2011
Xanthene food dye, as a modulator of Alzheimer's disease amyloid-beta peptide aggregation and the associated impaired neuronal cell function.PloS one, , Volume: 6, Issue:10, 2011
CSF α-synuclein concentrations do not fluctuate over hours and are not correlated to amyloid β in humans.Neuroscience letters, , Oct-31, Volume: 504, Issue:3, 2011
Caenorhabditis elegans as an experimental tool for the study of complex neurological diseases: Parkinson's disease, Alzheimer's disease and autism spectrum disorder.Invertebrate neuroscience : IN, , Volume: 11, Issue:2, 2011
Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes.Bioorganic & medicinal chemistry, , Dec-15, Volume: 19, Issue:24, 2011
[Role of genetics in the etiology of synucleinopathies].Revista espanola de geriatria y gerontologia, , Volume: 46 Suppl 1, 2011
α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study.The Lancet. Neurology, , Volume: 10, Issue:3, 2011
TAR-DNA binding protein-43 and alterations in the hippocampus.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 118, Issue:5, 2011
Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression.Annals of neurology, , Volume: 69, Issue:3, 2011
A novel mechanism of non-Aβ component of Alzheimer's disease amyloid (NAC) neurotoxicity. Interplay between p53 protein and cyclin-dependent kinase 5 (Cdk5).Neurochemistry international, , Volume: 58, Issue:2, 2011
The n-terminal 5-MER peptide analogue P165 of amyloid precursor protein exerts protective effects on SH-SY5Y cells and rat hippocampus neuronal synapses.Neuroscience, , Jan-26, Volume: 173, 2011
Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders.Acta neuropathologica, , Volume: 119, Issue:6, 2010
The Society for Neuroscience 2009 meeting report, part 2.Journal of Alzheimer's disease : JAD, , Volume: 19, Issue:4, 2010
CSF α-synuclein as a diagnostic biomarker for Parkinson disease and related dementias.Neurology, , Nov-16, Volume: 75, Issue:20, 2010
Bis(thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease.Journal of Alzheimer's disease : JAD, , Volume: 20, Issue:1, 2010
Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy.PloS one, , Feb-19, Volume: 5, Issue:2, 2010
Evidence in favor of Braak staging of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 25 Suppl 1, 2010
Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease.Neurology, , Nov-16, Volume: 75, Issue:20, 2010
Burden of neurodegenerative diseases in a cohort of medical examiner subjects.Journal of forensic sciences, , Volume: 55, Issue:3, 2010
Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease.Annals of neurology, , Volume: 67, Issue:4, 2010
Mitochondrial trafficking of APP and alpha synuclein: Relevance to mitochondrial dysfunction in Alzheimer's and Parkinson's diseases.Biochimica et biophysica acta, , Volume: 1802, Issue:1, 2010
Regulation of Weibel-Palade body exocytosis by alpha-synuclein in endothelial cells.The Journal of biological chemistry, , Jul-09, Volume: 285, Issue:28, 2010
Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline.The Journal of neuroscience : the official journal of the Society for Neuroscience, , May-26, Volume: 30, Issue:21, 2010
Frontal lobe white matter hyperintensities and neurofibrillary pathology in the oldest old.Neurology, , Dec-07, Volume: 75, Issue:23, 2010
[GSK-3beta: a central kinase for neurodegenerative diseases?].Medecine sciences : M/S, , Volume: 26, Issue:5, 2010
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-03, Volume: 30, Issue:9, 2010
CSF synuclein: adding to the biomarker footprint of dementia with Lewy bodies.Journal of neurology, neurosurgery, and psychiatry, , Volume: 81, Issue:6, 2010
Differential levels of alpha-synuclein, beta-amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer's disease.Journal of neurology, neurosurgery, and psychiatry, , Volume: 81, Issue:6, 2010
Neuropathological asymmetry in argyrophilic grain disease.Journal of neuropathology and experimental neurology, , Volume: 69, Issue:7, 2010
Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease.Neuroscience letters, , Aug-09, Volume: 480, Issue:1, 2010
Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jul-07, Volume: 30, Issue:27, 2010
Soluble and mature amyloid fibrils in drusen deposits.Investigative ophthalmology & visual science, , Volume: 51, Issue:3, 2010
Tau protein: relevance to Parkinson's disease.The international journal of biochemistry & cell biology, , Volume: 42, Issue:11, 2010
Chaperone-mediated autophagy markers in Parkinson disease brains.Archives of neurology, , Volume: 67, Issue:12, 2010
Structure and function of the molecular chaperone Hsp104 from yeast.Biopolymers, , Volume: 93, Issue:3, 2010
[Alpha-synuclein and Alzheimer's disease].Sheng li ke xue jin zhan [Progress in physiology], , Volume: 41, Issue:2, 2010
Abnormal neurites containing C-terminally truncated alpha-synuclein are present in Alzheimer's disease without conventional Lewy body pathology.The American journal of pathology, , Volume: 177, Issue:6, 2010
Prediction of pathology in primary progressive language and speech disorders.Neurology, , Jan-05, Volume: 74, Issue:1, 2010
CSF α-synuclein does not discriminate dementia with Lewy bodies from Alzheimer's disease.Journal of Alzheimer's disease : JAD, , Volume: 22, Issue:1, 2010
Neuropathology of dementia with Lewy bodies in advanced age: a comparison with Alzheimer disease.Neuroscience letters, , Nov-26, Volume: 485, Issue:3, 2010
Distribution of cerebral amyloid deposition and its relevance to clinical phenotype in Lewy body dementia.Neuroscience letters, , Dec-03, Volume: 486, Issue:1, 2010
DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease.Brain : a journal of neurology, , Volume: 133, Issue:Pt 3, 2010
Recurrent systemic infections with Streptococcus pneumoniae do not aggravate the course of experimental neurodegenerative diseases.Journal of neuroscience research, , Volume: 88, Issue:5, 2010
High-resolution temperature-concentration diagram of alpha-synuclein conformation obtained from a single Förster resonance energy transfer image in a microfluidic device.Analytical chemistry, , Aug-15, Volume: 81, Issue:16, 2009
In vitro characterisation of BF227 binding to alpha-synuclein/Lewy bodies.European journal of pharmacology, , Sep-01, Volume: 617, Issue:1-3, 2009
CSF alpha-synuclein levels in dementia with Lewy bodies and Alzheimer's disease.Brain research, , Jan-28, Volume: 1251, 2009
Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders.Acta neuropathologica, , Volume: 117, Issue:2, 2009
Trends in the molecular pathogenesis and clinical therapeutics of common neurodegenerative disorders.International journal of molecular sciences, , Jun-03, Volume: 10, Issue:6, 2009
Inhibitors of protein aggregation and toxicity.Biochemical Society transactions, , Volume: 37, Issue:Pt 4, 2009
Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies.Brain : a journal of neurology, , Volume: 132, Issue:Pt 4, 2009
Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders.Acta neuropathologica, , Volume: 117, Issue:2, 2009
Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases.Biochimica et biophysica acta, , Volume: 1790, Issue:7, 2009
Parkinson's disease dementia and dementia with Lewy bodies: different aspects of one entity.International psychogeriatrics, , Volume: 21, Issue:2, 2009
Exploiting a (13)C-labelled heparin analogue for in situ solid-state NMR investigations of peptide-glycan interactions within amyloid fibrils.Organic & biomolecular chemistry, , Jun-07, Volume: 7, Issue:11, 2009
Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss?Neuroscience letters, , Feb-06, Volume: 450, Issue:3, 2009
Mechanism of amyloidogenesis: nucleation-dependent fibrillation versus double-concerted fibrillation.BMB reports, , Sep-30, Volume: 42, Issue:9, 2009
[In-vivo imaging for pursuing molecular cascades in the pathogenesis of neurodegenerative diseases].Rinsho shinkeigaku = Clinical neurology, , Volume: 49, Issue:11, 2009
Intrinsic disorder in proteins associated with neurodegenerative diseases.Frontiers in bioscience (Landmark edition), , 06-01, Volume: 14, Issue:14, 2009
Lewy body variant of Alzheimer's disease: selective neocortical loss of t-SNARE proteins and loss of MAP2 and alpha-synuclein in medial temporal lobe.TheScientificWorldJournal, , Dec-16, Volume: 9, 2009
Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction.Acta neuropathologica, , Volume: 117, Issue:6, 2009
Criteria for the neuropathological diagnosis of dementing disorders: routes out of the swamp?Acta neuropathologica, , Volume: 117, Issue:2, 2009
Creutzfeldt-jakob, Parkinson, lewy body dementia and Alzheimer diseases: from diagnosis to therapy.Central nervous system agents in medicinal chemistry, , Volume: 9, Issue:1, 2009
Heavy alcohol consumption and neuropathological lesions: a post-mortem human study.Journal of neuroscience research, , Volume: 87, Issue:12, 2009
Quantitation and mapping of cerebral detergent-insoluble proteins in the elderly.Brain pathology (Zurich, Switzerland), , Volume: 19, Issue:3, 2009
MRI correlates of neurofibrillary tangle pathology at autopsy: a voxel-based morphometry study.Neurology, , Sep-02, Volume: 71, Issue:10, 2008
Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases.PloS one, , Sep-04, Volume: 3, Issue:9, 2008
[Molecular neuropathology of Non-Alzheimer dementia].Der Pathologe, , Volume: 29, Issue:6, 2008
Alpha- and gamma-synuclein proteins are present in cerebrospinal fluid and are increased in aged subjects with neurodegenerative and vascular changes.Dementia and geriatric cognitive disorders, , Volume: 26, Issue:1, 2008
[Near a biological diagnosis of Alzheimer's disease and related disorders].La Revue de medecine interne, , Volume: 29, Issue:10, 2008
alpha-Synuclein enhances secretion and toxicity of amyloid beta peptides in PC12 cells.Neurochemistry international, , Volume: 53, Issue:6-8, 2008
Co-localization of tau and alpha-synuclein in the olfactory bulb in Alzheimer's disease with amygdala Lewy bodies.Acta neuropathologica, , Volume: 116, Issue:1, 2008
Olfactory pathogenesis of idiopathic Parkinson disease revisited.Movement disorders : official journal of the Movement Disorder Society, , Jun-15, Volume: 23, Issue:8, 2008
Systematic appraisal using immunohistochemistry of brain pathology in aged and demented subjects.Dementia and geriatric cognitive disorders, , Volume: 25, Issue:5, 2008
Spontaneous aggregation and altered intracellular distribution of endogenous alpha-synuclein during neuronal apoptosis.Journal of Alzheimer's disease : JAD, , Volume: 13, Issue:2, 2008
Patterns and stages of alpha-synucleinopathy: Relevance in a population-based cohort.Neurology, , Mar-25, Volume: 70, Issue:13, 2008
Differences between normal and alpha-synuclein overexpressing SH-SY5Y neuroblastoma cells after Abeta(1-42) and NAC treatment.Brain research bulletin, , Mar-28, Volume: 75, Issue:5, 2008
Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies.Neuroscience, , Apr-09, Volume: 152, Issue:4, 2008
Differential expression of alpha-synuclein, parkin, and synphilin-1 isoforms in Lewy body disease.Neurogenetics, , Volume: 9, Issue:3, 2008
Characterization of fibrillation process of alpha-synuclein at the initial stage.Biochemical and biophysical research communications, , May-09, Volume: 369, Issue:3, 2008
Protein folding diseases and neurodegeneration: lessons learned from yeast.Biochimica et biophysica acta, , Volume: 1783, Issue:7, 2008
A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides.Nature neuroscience, , Volume: 11, Issue:3, 2008
Early discriminatory diagnosis of dementia with Lewy bodies. The emerging role of CSF and imaging biomarkers.Dementia and geriatric cognitive disorders, , Volume: 25, Issue:3, 2008
Noninvasive measurement of protein aggregation by mutant huntingtin fragments or alpha-synuclein in the lens.The Journal of biological chemistry, , Mar-07, Volume: 283, Issue:10, 2008
Commentary to "Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease".Neurochemical research, , Volume: 33, Issue:6, 2008
Identification and characterization of a new alpha-synuclein isoform and its role in Lewy body diseases.Neurogenetics, , Volume: 9, Issue:1, 2008
Evaluation of alpha-synuclein immunohistochemical methods used by invited experts.Acta neuropathologica, , Volume: 116, Issue:3, 2008
Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders.Autoimmunity reviews, , Volume: 7, Issue:6, 2008
The alpha-synuclein burden hypothesis of Parkinson disease and its relationship to Alzheimer disease.Experimental neurology, , Volume: 212, Issue:2, 2008
[Animal models of neurodegenerative diseases].Medecine sciences : M/S, , Volume: 23, Issue:2, 2007
Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-28, Volume: 27, Issue:48, 2007
Concurrence of TDP-43, tau and alpha-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies.Brain research, , Dec-12, Volume: 1184, 2007
Transgenic animal models of neurodegenerative diseases and their application to treatment development.Advanced drug delivery reviews, , Sep-30, Volume: 59, Issue:11, 2007
Differentiating Alzheimer disease-associated aggregates with small molecules.Neurobiology of disease, , Volume: 28, Issue:3, 2007
[Pathology of familial Parkinson's disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 59, Issue:8, 2007
In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution.Neurology, , Jul-24, Volume: 69, Issue:4, 2007
Nitration in neurodegeneration: deciphering the "Hows" "nYs".Biochemistry, , Jun-26, Volume: 46, Issue:25, 2007
alpha-Synuclein and its disease-related mutants interact differentially with the microtubule protein tau and associate with the actin cytoskeleton.Neurobiology of disease, , Volume: 26, Issue:3, 2007
A variable poly-T sequence modulates alpha-synuclein isoform expression and is associated with aging.Journal of neuroscience research, , May-15, Volume: 85, Issue:7, 2007
Lewy body variant of Alzheimer's disease or cerebral type lewy body disease? Two autopsy cases of presenile onset with minimal involvement of the brainstem.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 27, Issue:1, 2007
Tauopathies and synucleinopathies: do cerebrospinal fluid beta-amyloid peptides reflect disease-specific pathogenesis?Journal of neural transmission (Vienna, Austria : 1996), , Volume: 114, Issue:7, 2007
Mutant ubiquitin and p62 immunoreactivity in cases of combined multiple system atrophy and Alzheimer's disease.Acta neuropathologica, , Volume: 113, Issue:4, 2007
Tau and alpha-synuclein brainstem pathology in Alzheimer disease: relation with extrapyramidal signs.Acta neuropathologica, , Volume: 113, Issue:1, 2007
Cerebrospinal fluid of Alzheimer's disease and dementia with Lewy bodies patients enhances alpha-synuclein fibril formation in vitro.Experimental neurology, , Volume: 203, Issue:2, 2007
Identification of G-protein coupled receptor kinase 2 in paired helical filaments and neurofibrillary tangles.Journal of neuropathology and experimental neurology, , Volume: 65, Issue:12, 2006
Natural antisense transcripts of Alzheimer's disease associated genes.DNA sequence : the journal of DNA sequencing and mapping, , Volume: 17, Issue:2, 2006
[Nosology of dementias: the neuropathologist's point of view].Revue neurologique, , Volume: 162, Issue:10, 2006
A spectroscopic study of some of the peptidyl radicals formed following hydroxyl radical attack on beta-amyloid and alpha-synuclein.Free radical research, , Volume: 40, Issue:7, 2006
Small molecule oxidation products trigger disease-associated protein misfolding.Accounts of chemical research, , Volume: 39, Issue:9, 2006
Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease.Experimental & molecular medicine, , Aug-31, Volume: 38, Issue:4, 2006
Low alpha-synuclein 126 mRNA levels in dementia with Lewy bodies and Alzheimer disease.Neuroreport, , Aug-21, Volume: 17, Issue:12, 2006
Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease.Neurochemical research, , Volume: 31, Issue:9, 2006
Lewy body pathology in late-onset familial Alzheimer's disease: a clinicopathological case series.Journal of Alzheimer's disease : JAD, , Volume: 9, Issue:3, 2006
Linker histone H1 binds to disease associated amyloid-like fibrils.Journal of molecular biology, , Aug-18, Volume: 361, Issue:3, 2006
[Amyloid-beta protein vaccine therapy for alzheimer's disease].Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, , Jun-10, Volume: 95, Issue:6, 2006
Alzheimer disease with amygdala Lewy bodies: a distinct form of alpha-synucleinopathy.Journal of neuropathology and experimental neurology, , Volume: 65, Issue:7, 2006
Biochemical staging of synucleinopathy and amyloid deposition in dementia with Lewy bodies.Journal of neuropathology and experimental neurology, , Volume: 65, Issue:3, 2006
[Abeta, tau and alpha-synuclein and glial cells].Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, , Volume: 26, Issue:1, 2006
Lewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotype.Archives of neurology, , Volume: 63, Issue:3, 2006
Relation of quantitative indexes of concurrent alpha-synuclein abnormalities to clinical outcome in autopsy-proven Alzheimer disease.Archives of neurology, , Volume: 63, Issue:2, 2006
The distribution pattern of pathology and cholinergic deficits in amygdaloid complex in Alzheimer's disease and dementia with Lewy bodies.Acta neuropathologica, , Volume: 111, Issue:2, 2006
Nurr1 in Parkinson's disease and related disorders.The Journal of comparative neurology, , Jan-20, Volume: 494, Issue:3, 2006
Insoluble alpha-synuclein in Alzheimer's disease without Lewy body formation.Neurotoxicity research, , Volume: 7, Issue:1-2, 2005
Genetic association between the APOE*4 allele and Lewy bodies in Alzheimer disease.Neurology, , Feb-08, Volume: 64, Issue:3, 2005
A mutant PSEN1 causes dementia with Lewy bodies and variant Alzheimer's disease.Annals of neurology, , Volume: 57, Issue:3, 2005
Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA).Journal of neuropathology and experimental neurology, , Volume: 64, Issue:2, 2005
A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease.The Journal of biological chemistry, , Jun-17, Volume: 280, Issue:24, 2005
The pathology of the substantia nigra in Alzheimer disease with extrapyramidal signs.Neurology, , Apr-26, Volume: 64, Issue:8, 2005
Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases.The Journal of biological chemistry, , Jul-01, Volume: 280, Issue:26, 2005
Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA).Journal of neuropathology and experimental neurology, , Volume: 64, Issue:6, 2005
In vitro preparation of prefibrillar intermediates of amyloid-beta and alpha-synuclein.Methods in molecular biology (Clifton, N.J.), , Volume: 299, 2005
Cognitive differences in dementia patients with autopsy-verified AD, Lewy body pathology, or both.Neurology, , Jun-28, Volume: 64, Issue:12, 2005
Novel presenilin 1 mutation (S170F) causing Alzheimer disease with Lewy bodies in the third decade of life.Archives of neurology, , Volume: 62, Issue:12, 2005
New presenilin 1 mutation with Alzheimer disease and Lewy bodies.Archives of neurology, , Volume: 62, Issue:12, 2005
American Chemical Society 230th National Meeting. Neurological disorders.IDrugs : the investigational drugs journal, , Volume: 8, Issue:11, 2005
Metal ions and oxidative protein modification in neurological disease.Annali dell'Istituto superiore di sanita, , Volume: 41, Issue:2, 2005
The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy.British journal of pharmacology, , Volume: 146, Issue:8, 2005
How to diagnose dementia with Lewy bodies: state of the art.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
Engineered alpha-synuclein prevents wild type and familial Parkin variant fibril formation.Biochemical and biophysical research communications, , Sep-23, Volume: 335, Issue:2, 2005
Agrin binds alpha-synuclein and modulates alpha-synuclein fibrillation.Glycobiology, , Volume: 15, Issue:12, 2005
Chasing genes in Alzheimer's and Parkinson's disease.Human genetics, , Volume: 114, Issue:5, 2004
Dopamine and L-dopa disaggregate amyloid fibrils: implications for Parkinson's and Alzheimer's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 18, Issue:9, 2004
Alpha-synuclein, Parkinson's disease, and Alzheimer's disease.Parkinsonism & related disorders, , Volume: 10 Suppl 1, 2004
Cross-linking of ubiquitin, HSP27, parkin, and alpha-synuclein by gamma-glutamyl-epsilon-lysine bonds in Alzheimer's neurofibrillary tangles.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 18, Issue:10, 2004
ABri peptide associated with familial British dementia forms annular and ring-like protofibrillar structures.Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, , Volume: 11, Issue:1, 2004
Lewy body-related alpha-synucleinopathy in the aged human brain.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 111, Issue:10-11, 2004
Differential expression of alpha-synuclein isoforms in dementia with Lewy bodies.Neuropathology and applied neurobiology, , Volume: 30, Issue:6, 2004
Nucleus-specific alteration of raphe neurons in human neurodegenerative disorders.Neuroreport, , Jan-20, Volume: 14, Issue:1, 2003
Alpha-synuclein, Abeta and Alzheimer's disease.Progress in neuro-psychopharmacology & biological psychiatry, , Volume: 27, Issue:1, 2003
Recent advances on alpha-synuclein cell biology: functions and dysfunctions.Current molecular medicine, , Volume: 3, Issue:1, 2003
Ubiquitinated inclusions and neuronal cell death.Histology and histopathology, , Volume: 18, Issue:2, 2003
Lewy body pathology is a frequent co-pathology in familial Alzheimer's disease.Acta neuropathologica, , Volume: 105, Issue:5, 2003
Regional distribution of alpha-synuclein pathology in unimpaired aging and Alzheimer disease.Journal of neuropathology and experimental neurology, , Volume: 62, Issue:4, 2003
Alpha-synuclein-positive structures in association with diffuse neurofibrillary tangles with calcification.Neuropathology and applied neurobiology, , Volume: 29, Issue:3, 2003
Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease.Neuropharmacology, , Volume: 45, Issue:1, 2003
Alpha-synuclein pathology in Parkinson's and Alzheimer's disease brain: incidence and topographic distribution--a pilot study.Acta neuropathologica, , Volume: 106, Issue:3, 2003
Variability and heterogeneity in Alzheimer's disease with cotton wool plaques: a clinicopathological study of four autopsy cases.Acta neuropathologica, , Volume: 106, Issue:4, 2003
Toward a molecular neuropsychiatry of neurodegenerative diseases.Annals of neurology, , Volume: 54, Issue:2, 2003
Dissociation of amyloid fibrils of alpha-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities.Proceedings of the National Academy of Sciences of the United States of America, , Aug-19, Volume: 100, Issue:17, 2003
Age-associated prevalence and risk factors of Lewy body pathology in a general population: the Hisayama study.Acta neuropathologica, , Volume: 106, Issue:4, 2003
Tau pathology in the olfactory bulb correlates with Braak stage, Lewy body pathology and apolipoprotein epsilon4.Neuropathology and applied neurobiology, , Volume: 29, Issue:5, 2003
Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer's and Parkinson's diseases.Neuromolecular medicine, , Volume: 4, Issue:1-2, 2003
[Lewy bodies, a misleading marker for Parkinson's disease?].Bulletin de l'Academie nationale de medecine, , Volume: 187, Issue:2, 2003
Neuritic alterations and neural system dysfunction in Alzheimer's disease and dementia with Lewy bodies.Neurochemical research, , Volume: 28, Issue:11, 2003
Cycles of aberrant synaptic sprouting and neurodegeneration in Alzheimer's and dementia with Lewy bodies.Neurochemical research, , Volume: 28, Issue:11, 2003
Neurodegenerative disease: amyloid pores from pathogenic mutations.Nature, , Jul-18, Volume: 418, Issue:6895, 2002
Clusterin/apolipoprotein J is associated with cortical Lewy bodies: immunohistochemical study in cases with alpha-synucleinopathies.Acta neuropathologica, , Volume: 104, Issue:3, 2002
Aggregation and neurotoxicity of alpha-synuclein and related peptides.Biochemical Society transactions, , Volume: 30, Issue:4, 2002
Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease.Pharmacological reviews, , Volume: 54, Issue:3, 2002
NACP/alpha-synuclein, NAC, and beta-amyloid pathology of familial Alzheimer's disease with the E184D presenilin-1 mutation: a clinicopathological study of two autopsy cases.Acta neuropathologica, , Volume: 104, Issue:6, 2002
TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation.Journal of neurochemistry, , Volume: 83, Issue:4, 2002
[Gene diagnosis of Alzheimer's disease and Parkinson's disease].Rinsho byori. The Japanese journal of clinical pathology, , Volume: 50, Issue:10, 2002
Expression of alpha-synuclein, the precursor of non-amyloid beta component of Alzheimer's disease amyloid, in human cerebral blood vessels.Neuroscience letters, , Jun-21, Volume: 326, Issue:1, 2002
Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease.Free radical biology & medicine, , Jun-01, Volume: 32, Issue:11, 2002
Alzheimer's and Parkinson's disease--overlapping or synergistic pathologies?Trends in molecular medicine, , Volume: 8, Issue:1, 2002
Production of reactive oxygen species from aggregating proteins implicated in Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases.Current topics in medicinal chemistry, , Volume: 1, Issue:6, 2001
Lewy body pathology in Alzheimer's disease.Journal of molecular neuroscience : MN, , Volume: 17, Issue:2, 2001
Alpha-synuclein in familial Alzheimer disease: epitope mapping parallels dementia with Lewy bodies and Parkinson disease.Archives of neurology, , Volume: 58, Issue:11, 2001
Altered expression of the synuclein family mRNA in Lewy body and Alzheimer's disease.Brain research, , Sep-28, Volume: 914, Issue:1-2, 2001
beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , Oct-09, Volume: 98, Issue:21, 2001
Alpha-synuclein pathology is highly dependent on the case selection.Neuropathology and applied neurobiology, , Volume: 27, Issue:4, 2001
Postnatal expression of alpha-synuclein protein in the rodent substantia nigra and striatum.Developmental neuroscience, , Volume: 23, Issue:2, 2001
Neuropathological correlates to clinically defined dementia with Lewy bodies.International journal of geriatric psychiatry, , Volume: 16, Issue:7, 2001
Identification of the region of non-Abeta component (NAC) of Alzheimer's disease amyloid responsible for its aggregation and toxicity.Journal of neurochemistry, , Volume: 78, Issue:2, 2001
[Alpha-synucleinopathies].Neurologia (Barcelona, Spain), , Volume: 16, Issue:4, 2001
Mouse models of alpha-synucleinopathy and Lewy pathology. Alpha-synuclein expression in transgenic mice.Advances in experimental medicine and biology, , Volume: 487, 2001
beta-amyloid deposits in transgenic mice expressing human beta-amyloid precursor protein have the same characteristics as those in Alzheimer's disease.Neuroscience, , Volume: 104, Issue:2, 2001
Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins.Mechanisms of ageing and development, , Jul-15, Volume: 122, Issue:9, 2001
Alpha-synuclein-positive structures in cases with sporadic Alzheimer's disease: morphology and its relationship to tau aggregation.Brain research, , Jan-12, Volume: 888, Issue:2, 2001
Alpha-synuclein and Parkinson's disease.Cellular and molecular life sciences : CMLS, , Volume: 57, Issue:13-14, 2000
Lewy body variant of Alzheimer's disease: alpha-synuclein in dystrophic neurites of A beta plaques.Neuroreport, , Nov-27, Volume: 11, Issue:17, 2000
Activated microglial cells and complement factors are unrelated to cortical Lewy bodies.Acta neuropathologica, , Volume: 100, Issue:6, 2000
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions.Science (New York, N.Y.), , Nov-03, Volume: 290, Issue:5493, 2000
Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease.Acta neuropathologica, , Volume: 100, Issue:3, 2000
Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease.The American journal of pathology, , Volume: 157, Issue:2, 2000
Late-onset neurodegenerative diseases--the role of protein insolubility.Journal of anatomy, , Volume: 196 ( Pt 4), 2000
Properties of NACP/alpha-synuclein and its role in Alzheimer's disease.Biochimica et biophysica acta, , Jul-26, Volume: 1502, Issue:1, 2000
Alpha-synuclein inclusions in Alzheimer and Lewy body diseases.Journal of neuropathology and experimental neurology, , Volume: 59, Issue:5, 2000
Lewy bodies in Alzheimer's disease: a neuropathological review of 145 cases using alpha-synuclein immunohistochemistry.Brain pathology (Zurich, Switzerland), , Volume: 10, Issue:3, 2000
Accumulation of insoluble alpha-synuclein in dementia with Lewy bodies.Neurobiology of disease, , Volume: 7, Issue:3, 2000
Metal-catalyzed oxidation of alpha-synuclein in the presence of Copper(II) and hydrogen peroxide.Archives of biochemistry and biophysics, , Jun-15, Volume: 378, Issue:2, 2000
Involvement of alpha-synuclein in Parkinson's disease and other neurodegenerative disorders.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 107, Issue:1, 2000
Toxicity of non-abeta component of Alzheimer's disease amyloid, and N-terminal fragments thereof, correlates to formation of beta-sheet structure and fibrils.European journal of biochemistry, , Volume: 267, Issue:8, 2000
Occurrence of human alpha-synuclein immunoreactive neurons with neurofibrillary tangle formation in the limbic areas of patients with Alzheimer's disease.Journal of the neurological sciences, , Mar-15, Volume: 174, Issue:2, 2000
The role of NAC in amyloidogenesis in Alzheimer's disease.The American journal of pathology, , Volume: 156, Issue:2, 2000
Plaque-associated alpha-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor protein.Brain research, , Jan-24, Volume: 853, Issue:2, 2000
Stains for the differential diagnosis of degenerative dementias.Biotechnic & histochemistry : official publication of the Biological Stain Commission, , Volume: 74, Issue:6, 1999
The expression of alpha-, beta-, and gamma-synucleins in olfactory mucosa from patients with and without neurodegenerative diseases.Experimental neurology, , Volume: 160, Issue:2, 1999
Alpha-synuclein in Lewy body disease and Alzheimer's disease.Brain pathology (Zurich, Switzerland), , Volume: 9, Issue:4, 1999
Non-Abeta component of Alzheimer's disease amyloid (NAC) revisited. NAC and alpha-synuclein are not associated with Abeta amyloid.The American journal of pathology, , Volume: 155, Issue:4, 1999
Neural expression profile of alpha-synuclein in developing human cortex.Neuroreport, , Sep-09, Volume: 10, Issue:13, 1999
The genetics of disorders with synuclein pathology and parkinsonism.Human molecular genetics, , Volume: 8, Issue:10, 1999
Alpha-synuclein accumulates in Lewy bodies in Parkinson's disease and dementia with Lewy bodies but not in Alzheimer's disease beta-amyloid plaque cores.Neuroscience letters, , May-14, Volume: 266, Issue:3, 1999
Filamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and alpha-synucleinopathies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences, , Jun-29, Volume: 354, Issue:1386, 1999
Copper(II)-induced self-oligomerization of alpha-synuclein.The Biochemical journal, , Jun-15, Volume: 340 ( Pt 3), 1999
Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro.Neuroreport, , Mar-17, Volume: 10, Issue:4, 1999
Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease.Annals of neurology, , Volume: 45, Issue:3, 1999
Novel alpha-synuclein-immunoreactive proteins in brain samples from the Contursi kindred, Parkinson's, and Alzheimer's disease.Experimental neurology, , Volume: 154, Issue:2, 1998
Alpha synuclein is present in Lewy bodies in sporadic Parkinson's disease.Molecular psychiatry, , Volume: 3, Issue:6, 1998
Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes.The American journal of pathology, , Volume: 153, Issue:5, 1998
Intraneuronal filamentous tau protein and alpha-synuclein deposits in neurodegenerative diseases.Biochemical Society transactions, , Volume: 26, Issue:3, 1998
The synuclein family.Genome research, , Volume: 8, Issue:9, 1998
Mutation in the alpha-synuclein gene and sporadic Parkinson's disease, Alzheimer's disease, and dementia with lewy bodies.Experimental neurology, , Volume: 153, Issue:1, 1998
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alpha-Synuclein--a link between Parkinson and Alzheimer diseases?Nature genetics, , Volume: 16, Issue:4, 1997
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Tracer development for PET imaging of proteinopathies.Nuclear medicine and biology, , Volume: 114-115
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Default mode network connectivity is linked to cognitive functioning and CSF Aβ1-42 levels in Alzheimer's disease.Archives of gerontology and geriatrics, , Volume: 62
Alpha-synuclein Levels in the Differential Diagnosis of Lewy Bodies Dementia and Other Neurodegenerative Disorders: A Meta-analysis.Alzheimer disease and associated disorders, , Volume: 34, Issue:3
Could it be that neurodegenerative diseases are infectious?Revue neurologique, , Volume: 175, Issue:7-8
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A review on the cause-effect relationship between oxidative stress and toxic proteins in the pathogenesis of neurodegenerative diseases.Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, , Volume: 118, Issue:1
Development of a new treatment for Alzheimer's disease and Parkinson's disease using anti-aggregatory beta-synuclein-derived peptides.Journal of molecular neuroscience : MN, , Volume: 19, Issue:1-2
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Locus Coeruleus Pathology Indicates a Continuum of Lewy Body Dementia.Journal of Parkinson's disease, , Volume: 11, Issue:4
Abeta deposition is associated with enhanced cortical alpha-synuclein lesions in Lewy body diseases.Neurobiology of aging, , Volume: 26, Issue:8
Parkinson's disease: the thalamic components of the limbic loop are severely impaired by alpha-synuclein immunopositive inclusion body pathology.Neurobiology of aging, , Volume: 23, Issue:2
Genetic association between Alzheimer disease and the alpha-synuclein gene.Dementia and geriatric cognitive disorders, , Volume: 12, Issue:2
Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases.Molecular medicine (Cambridge, Mass.), , Volume: 14, Issue:7-8
Alpha-synuclein in the cerebrospinal fluid differentiates synucleinopathies (Parkinson Disease, dementia with Lewy bodies, multiple system atrophy) from Alzheimer disease.Alzheimer disease and associated disorders, , Volume: 26, Issue:3
A statistical and biological approach for identifying misdiagnosis of incipient Alzheimer patients using gene expression data.Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, , Volume: 2006
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Decreased Levels of VAMP2 and Monomeric Alpha-Synuclein Correlate with Duration of Dementia.Journal of Alzheimer's disease : JAD, , Volume: 50, Issue:1, 2016
Therapeutic approaches in Parkinson's disease and related disorders.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
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Curcumin Treatment Improves Motor Behavior in α-Synuclein Transgenic Mice.PloS one, , Volume: 10, Issue:6, 2015
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The significance of α-synuclein, amyloid-β and tau pathologies in Parkinson's disease progression and related dementia.Neuro-degenerative diseases, , Volume: 13, Issue:2-3, 2014
A quantitative study of α-synuclein pathology in fifteen cases of dementia associated with Parkinson disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 121, Issue:2, 2014
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Dysfunction of the locus coeruleus-norepinephrine system and related circuitry in Parkinson's disease-related dementia.Journal of neurology, neurosurgery, and psychiatry, , Volume: 84, Issue:7, 2013
Identification of the sites of tau hyperphosphorylation and activation of tau kinases in synucleinopathies and Alzheimer's diseases.PloS one, , Volume: 8, Issue:9, 2013
SMG1 identified as a regulator of Parkinson's disease-associated alpha-synuclein through siRNA screening.PloS one, , Volume: 8, Issue:10, 2013
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Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 22, Issue:1, 2012
Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H β-synuclein.Molecular brain, , Sep-26, Volume: 5, 2012
Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.Autophagy, , May-01, Volume: 8, Issue:5, 2012
Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders.Archives of neurology, , Volume: 69, Issue:11, 2012
Altered CSF orexin and α-synuclein levels in dementia patients.Journal of Alzheimer's disease : JAD, , Volume: 29, Issue:1, 2012
α-Synuclein pathology in the amyotrophic lateral sclerosis/parkinsonism dementia complex in the Kii Peninsula, Japan.Journal of neuropathology and experimental neurology, , Volume: 71, Issue:7, 2012
Pathobiochemical effect of acylated steryl-β-glucoside on aggregation and cytotoxicity of α-synuclein.Neurochemical research, , Volume: 37, Issue:6, 2012
Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-21, Volume: 32, Issue:12, 2012
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Cerebrospinal fluid Tau/α-synuclein ratio in Parkinson's disease and degenerative dementias.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:8, 2011
Epidemiological neuropathology: the MRC Cognitive Function and Aging Study experience.Journal of Alzheimer's disease : JAD, , Volume: 25, Issue:2, 2011
Prevalence and pathology of dementia with Lewy bodies in the oldest old: a comparison with other dementing disorders.Dementia and geriatric cognitive disorders, , Volume: 31, Issue:4, 2011
Alpha- and beta-synuclein expression in Parkinson disease with and without dementia.Journal of the neurological sciences, , Nov-15, Volume: 310, Issue:1-2, 2011
[108th Scientific Meeting of the Japanese Society of Internal Medicine: symposium: 1. Progress in dementia research--dementia disorders and protein; (3) alpha-synuclein, alpha-synucleinopathies, and dementia].Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, , Sep-10, Volume: 100, Issue:9, 2011
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In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia.Neurology, , Jan-05, Volume: 74, Issue:1, 2010
The progression of pathology in Parkinson's disease.Annals of the New York Academy of Sciences, , Volume: 1184, 2010
Neuropathological asymmetry in argyrophilic grain disease.Journal of neuropathology and experimental neurology, , Volume: 69, Issue:7, 2010
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85-year old man with Parkinson's disease accompanying dementia.Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 62, Issue:6, 2010
Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia.Experimental neurology, , Volume: 225, Issue:1, 2010
CSF α-synuclein as a diagnostic biomarker for Parkinson disease and related dementias.Neurology, , Nov-16, Volume: 75, Issue:20, 2010
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Protein coding of neurodegenerative dementias: the neuropathological basis of biomarker diagnostics.Acta neuropathologica, , Volume: 119, Issue:4, 2010
Biomarkers: Parkinson disease with dementia and dementia with Lewy bodies.Parkinsonism & related disorders, , Volume: 16, Issue:5, 2010
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Heavy alcohol consumption and neuropathological lesions: a post-mortem human study.Journal of neuroscience research, , Volume: 87, Issue:12, 2009
Intralaminar nuclei of the thalamus in Lewy body diseases.Brain research bulletin, , Feb-16, Volume: 78, Issue:2-3, 2009
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Alpha-synuclein multiplications with parkinsonism, dementia or progressive myoclonus?Parkinsonism & related disorders, , Volume: 15, Issue:5, 2009
The morbid anatomy of dementia in Parkinson's disease.Acta neuropathologica, , Volume: 118, Issue:5, 2009
Cellular glutathione peroxidase in human brain: cellular distribution, and its potential role in the degradation of Lewy bodies in Parkinson's disease and dementia with Lewy bodies.Acta neuropathologica, , Volume: 117, Issue:1, 2009
The ALS/PDC syndrome of Guam and the cycad hypothesis.Neurology, , Feb-03, Volume: 72, Issue:5, 2009
The paradoxical cell biology of alpha-Synucle.Results and problems in cell differentiation, , Volume: 48, 2009
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Striatal beta-amyloid deposition in Parkinson disease with dementia.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:2, 2008
Clinicopathologic study of a SNCA gene duplication patient with Parkinson disease and dementia.Neurology, , Jan-15, Volume: 70, Issue:3, 2008
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Alpha-synuclein promoter haplotypes and dementia in Parkinson's disease.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, , Apr-05, Volume: 147, Issue:3, 2008
Mutation analyses in amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula, Japan.Movement disorders : official journal of the Movement Disorder Society, , Dec-15, Volume: 23, Issue:16, 2008
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Alpha-synuclein pathology in the olfactory pathways of dementia patients.Journal of anatomy, , Volume: 211, Issue:1, 2007
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Beta-amlyoid 1-42 and tau-protein in cerebrospinal fluid of patients with Parkinson's disease dementia.Dementia and geriatric cognitive disorders, , Volume: 22, Issue:3, 2006
Characterization of ubiquitinated intraneuronal inclusions in a novel Belgian frontotemporal lobar degeneration family.Journal of neuropathology and experimental neurology, , Volume: 65, Issue:3, 2006
Characterization of tau pathologies in gray and white matter of Guam parkinsonism-dementia complex.Acta neuropathologica, , Volume: 111, Issue:5, 2006
Alpha-synuclein pathology does not predict extrapyramidal symptoms or dementia.Annals of neurology, , Volume: 57, Issue:1, 2005
Tau and alpha-synuclein inclusions in a case of familial frontotemporal dementia and progressive aphasia.Journal of neuropathology and experimental neurology, , Volume: 64, Issue:3, 2005
p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies.The Journal of biological chemistry, , Feb-18, Volume: 280, Issue:7, 2005
17q-linked frontotemporal dementia-amyotrophic lateral sclerosis without tau mutations with tau and alpha-synuclein inclusions.Archives of neurology, , Volume: 61, Issue:3, 2004
Occurrence of alpha-synuclein pathology in the cerebellum of Guamanian patients with parkinsonism-dementia complex.Acta neuropathologica, , Volume: 107, Issue:6, 2004
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No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found.Neuroscience letters, , Jun-10, Volume: 363, Issue:2, 2004
Limbic neuropathology in idiopathic Parkinson's disease with concomitant dementia.Folia neuropathologica, , Volume: 42, Issue:3, 2004
Extrapyramidal features in patients with motor neuron disease and dementia; a clinicopathological correlative study.Acta neuropathologica, , Volume: 107, Issue:4, 2004
Tissue transglutaminase-induced aggregation of alpha-synuclein: Implications for Lewy body formation in Parkinson's disease and dementia with Lewy bodies.Proceedings of the National Academy of Sciences of the United States of America, , Feb-18, Volume: 100, Issue:4, 2003
Pathological involvement of the motor neuron system and hippocampal formation in motor neuron disease-inclusion dementia.Acta neuropathologica, , Volume: 106, Issue:1, 2003
Familial and sporadic Parkinson's disease usually display the same clinical features.Parkinsonism & related disorders, , Volume: 9, Issue:4, 2003
Accumulation of phosphorylated alpha-synuclein in aging human brain.Journal of neuropathology and experimental neurology, , Volume: 62, Issue:6, 2003
Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism.Neurology, , Jul-08, Volume: 61, Issue:1, 2003
NACP/alpha-synuclein immunoreactivity in diffuse neurofibrillary tangles with calcification (DNTC).Acta neuropathologica, , Volume: 104, Issue:4, 2002
Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam.The American journal of pathology, , Volume: 160, Issue:5, 2002
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Accumulation of human alpha-synuclein in different cytoskeletons in Lewy bodies in brains of dementia with Lewy bodies.Neuroscience letters, , Aug-18, Volume: 290, Issue:1, 2000
Alpha-synuclein inclusions in amygdala in the brains of patients with the parkinsonism-dementia complex of Guam.Journal of neuropathology and experimental neurology, , Volume: 59, Issue:7, 2000
Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease.Neurology, , May-23, Volume: 54, Issue:10, 2000
Microtubule-associated protein tau, heparan sulphate and alpha-synuclein in several neurodegenerative diseases with dementia.Acta neuropathologica, , Volume: 97, Issue:6, 1999
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Aggregation of neurofilament and alpha-synuclein proteins in Lewy bodies: implications for the pathogenesis of Parkinson disease and Lewy body dementia.Archives of neurology, , Volume: 55, Issue:2, 1998
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Early and extensive alterations of glial connexins, distal oligodendrogliopathy type demyelination, and nodal/paranodal pathology are characteristic of multiple system atrophy.Brain pathology (Zurich, Switzerland), , Volume: 33, Issue:3, 2023
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Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy.Molecular neurodegeneration, , Mar-19, Volume: 10, 2015
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Intracellular alpha-synuclein affects early maturation of primary oligodendrocyte progenitor cells.Molecular and cellular neurosciences, , Volume: 62, 2014
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How gut microbes could drive brain disorders.Nature, , Volume: 590, Issue:7844, 2021
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Mangosteen Pericarp and Its Bioactive Xanthones: Potential Therapeutic Value in Alzheimer's Disease, Parkinson's Disease, and Depression with Pharmacokinetic and Safety Profiles.International journal of molecular sciences, , Aug-27, Volume: 21, Issue:17, 2020
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Increased Serum Levels of α-Synuclein in Patients With Major Depressive Disorder.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, , Volume: 27, Issue:3, 2019
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Aggregation and Cellular Toxicity of Pathogenic or Non-pathogenic Proteins.Scientific reports, , 03-20, Volume: 10, Issue:1, 2020
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Modulation of Disordered Proteins with a Focus on Neurodegenerative Diseases and Other Pathologies.International journal of molecular sciences, , Mar-15, Volume: 20, Issue:6, 2019
Diabetes mellitus and Parkinson disease.Neurology, , 05-08, Volume: 90, Issue:19, 2018
Interaction of amyloidogenic proteins in pancreatic β cells from subjects with synucleinopathies.Acta neuropathologica, , Volume: 135, Issue:6, 2018
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Inhibition of Amyloid Protein Aggregation Using Selected Peptidomimetics.ChemMedChem, , 01-17, Volume: 18, Issue:2, 2023
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Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation.Diabetologia, , Volume: 65, Issue:8, 2022
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Dementia with Lewy bodies in an elderly Greek male due to alpha-synuclein gene mutation.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, , Volume: 13, Issue:9, 2006
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Involvement of Abnormal p-α-syn Accumulation and TLR2-Mediated Inflammation of Schwann Cells in Enteric Autonomic Nerve Dysfunction of Parkinson's Disease: an Animal Model Study.Molecular neurobiology, , Volume: 60, Issue:8, 2023
Mitochondrial signaling on innate immunity activation in Parkinson disease.Current opinion in neurobiology, , Volume: 78, 2023
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Alpha Synuclein: Neurodegeneration and Inflammation.International journal of molecular sciences, , Mar-21, Volume: 24, Issue:6, 2023
Myrcene Salvages Rotenone-Induced Loss of Dopaminergic Neurons by Inhibiting Oxidative Stress, Inflammation, Apoptosis, and Autophagy.Molecules (Basel, Switzerland), , Jan-10, Volume: 28, Issue:2, 2023
Investigation of Inflammation in Lewy Body Dementia: A Systematic Scoping Review.International journal of molecular sciences, , Jul-28, Volume: 24, Issue:15, 2023
Alpha-synuclein in Parkinson's disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction.Cell death & disease, , 03-01, Volume: 14, Issue:3, 2023
Helicobacter hepaticus augmentation triggers Dopaminergic degeneration and motor disorders in mice with Parkinson's disease.Molecular psychiatry, , Volume: 28, Issue:3, 2023
The Mediating Role of Inflammation in the Relationship Between α-Synuclein and Cognitive Functioning.The journals of gerontology. Series A, Biological sciences and medical sciences, , 02-24, Volume: 78, Issue:2, 2023
Lewy bodies, iron, inflammation and neuromelanin: pathological aspects underlying Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 130, Issue:5, 2023
Three-dimensional neuroimmune co-culture system for modeling Parkinson's disease microenvironmentsBiofabrication, , 07-10, Volume: 15, Issue:4, 2023
The Hyperproliferation Mechanism of Cholesteatoma Based on Proteomics: SNCA Promotes Autophagy-Mediated Cell Proliferation Through the PI3K/AKT/CyclinD1 Signaling Pathway.Molecular & cellular proteomics : MCP, , Volume: 22, Issue:9, 2023
Necrosulfonamide exerts neuroprotective effect by inhibiting necroptosis, neuroinflammation, and α-synuclein oligomerization in a subacute MPTP mouse model of Parkinson's disease.Scientific reports, , 05-31, Volume: 13, Issue:1, 2023
Coumarin-chalcone hybrid LM-021 and indole derivative NC009-1 targeting inflammation and oxidative stress to protect BE(2)-M17 cells against α-synuclein toxicity.Aging, , 08-11, Volume: 15, Issue:16, 2023
Cntnap4 partial deficiency exacerbates α-synuclein pathology through astrocyte-microglia C3-C3aR pathway.Cell death & disease, , 04-22, Volume: 14, Issue:4, 2023
Role of enteric glia and microbiota-gut-brain axis in parkinson disease pathogenesis.Ageing research reviews, , Volume: 84, 2023
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Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of Parkinson disease.Nature communications, , 06-26, Volume: 14, Issue:1, 2023
Revisiting Alpha-Synuclein Pathways to Inflammation.International journal of molecular sciences, , Apr-12, Volume: 24, Issue:8, 2023
Inflammasome Activation in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
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Neuroinflammation in Parkinson's Disease and its Treatment Opportunities.Balkan medical journal, , 09-09, Volume: 39, Issue:5, 2022
Oligomeric α-Synuclein induces skin degeneration in reconstructed human epidermis.Neurobiology of aging, , Volume: 113, 2022
Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD.Molecular neurodegeneration, , 09-05, Volume: 17, Issue:1, 2022
Mechanisms of NLRP3 activation and pathology during neurodegeneration.The international journal of biochemistry & cell biology, , Volume: 151, 2022
Role of NLRP3 Inflammasome in Parkinson's Disease and Therapeutic Considerations.Journal of Parkinson's disease, , Volume: 12, Issue:7, 2022
Microgliosis and neuronal proteinopathy in brain persist beyond viral clearance in SARS-CoV-2 hamster model.EBioMedicine, , Volume: 79, 2022
Cholecystokinin and glucagon-like peptide-1 analogues regulate intestinal tight junction, inflammation, dopaminergic neurons and α-synuclein accumulation in the colon of two Parkinson's disease mouse models.European journal of pharmacology, , Jul-05, Volume: 926, 2022
Therapeutic Strategies for Immune Transformation in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
Human gut microbiota and Parkinson's disease.Progress in molecular biology and translational science, , Volume: 192, Issue:1, 2022
Fucosylated Chondroitin Sulfate against Parkinson's Disease through Inhibiting Inflammation Induced by Gut Dysbiosis.Journal of agricultural and food chemistry, , Oct-26, Volume: 70, Issue:42, 2022
New Insights and Implications of Natural Killer Cells in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
Ischemic stroke causes Parkinson's disease-like pathology and symptoms in transgenic mice overexpressing alpha-synuclein.Acta neuropathologica communications, , 02-24, Volume: 10, Issue:1, 2022
GM1 ganglioside modifies microglial and neuroinflammatory responses to α-synuclein in the rat AAV-A53T α-synuclein model of Parkinson's disease.Molecular and cellular neurosciences, , Volume: 120, 2022
Dysregulation of peripheral monocytes and pro-inflammation of alpha-synuclein in Parkinson's disease.Journal of neurology, , Volume: 269, Issue:12, 2022
Inflammation promotes synucleinopathy propagation.Experimental & molecular medicine, , Volume: 54, Issue:12, 2022
Central and Peripheral Inflammation: Connecting the Immune Responses of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
Xanthotoxin modulates oxidative stress, inflammation, and MAPK signaling in a rotenone-induced Parkinson's disease model.Life sciences, , Dec-01, Volume: 310, 2022
Leveraging the preformed fibril model to distinguish between alpha-synuclein inclusion- and nigrostriatal degeneration-associated immunogenicity.Neurobiology of disease, , Volume: 171, 2022
Effects of miRNAs in exosomes derived from α-synuclein overexpressing SH-SY5Y cells on autophagy and inflammation of microglia.Cellular signalling, , Volume: 89, 2022
LRRK2 Inhibition Mitigates the Neuroinflammation Caused by TLR2-Specific α-Synuclein and Alleviates Neuroinflammation-Derived Dopaminergic Neuronal Loss.Cells, , 03-02, Volume: 11, Issue:5, 2022
TNF-α promotes α-synuclein propagation through stimulation of senescence-associated lysosomal exocytosis.Experimental & molecular medicine, , Volume: 54, Issue:6, 2022
The influence of preconditioning with low dose of LPS on paraquat-induced neurotoxicity, microglia activation and expression of α-synuclein and synphilin-1 in the dopaminergic system.Pharmacological reports : PR, , Volume: 74, Issue:1, 2022
Further Characterization of Intrastriatal Lipopolysaccharide Model of Parkinson's Disease in C57BL/6 Mice.International journal of molecular sciences, , Jul-09, Volume: 22, Issue:14, 2021
The Nigral Coup in Parkinson's Disease by α-Synuclein and Its Associated Rebels.Cells, , 03-09, Volume: 10, Issue:3, 2021
The Alpha-Synuclein RT-QuIC Products Generated by the Olfactory Mucosa of Patients with Parkinson's Disease and Multiple System Atrophy Induce Inflammatory Responses in SH-SY5Y Cells.Cells, , 12-28, Volume: 11, Issue:1, 2021
NLRP3 Inflammasome Inhibition Prevents α-Synuclein Pathology by Relieving Autophagy Dysfunction in Chronic MPTP-Treated NLRP3 Knockout Mice.Molecular neurobiology, , Volume: 58, Issue:4, 2021
Inflammation and Parkinson's disease pathogenesis: Mechanisms and therapeutic insight.Progress in molecular biology and translational science, , Volume: 177, 2021
EphA1 Activation Induces Neuropathological Changes in a Mouse Model of Parkinson's Disease Through the CXCL12/CXCR4 Signaling Pathway.Molecular neurobiology, , Volume: 58, Issue:3, 2021
Inflammation in Experimental Models of α-Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:1, 2021
Metabotropic glutamate receptor 5 inhibits α-synuclein-induced microglia inflammation to protect from neurotoxicity in Parkinson's disease.Journal of neuroinflammation, , Jan-18, Volume: 18, Issue:1, 2021
Velvet Antler Methanol Extracts Ameliorate Parkinson's Disease by Inhibiting Oxidative Stress and Neuroinflammation: From Oxidative medicine and cellular longevity, , Volume: 2021, 2021
Pursuing Multiple Biomarkers for Early Idiopathic Parkinson's Disease Diagnosis.Molecular neurobiology, , Volume: 58, Issue:11, 2021
Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes.Cell, , 09-30, Volume: 184, Issue:20, 2021
The role of innate immunity and inflammation in Parkinson´s disease.Scandinavian journal of immunology, , Volume: 93, Issue:5, 2021
Alpha-synuclein increases in rodent and human spinal cord injury and promotes inflammation and tissue loss.Scientific reports, , 06-03, Volume: 11, Issue:1, 2021
Alpha-Synuclein-induced DNA Methylation and Gene Expression in Microglia.Neuroscience, , 08-01, Volume: 468, 2021
Peripheral inflammation exacerbates α-synuclein toxicity and neuropathology in Parkinson's models.Neuropathology and applied neurobiology, , Volume: 47, Issue:1, 2021
Tat-p27 Ameliorates Neuronal Damage Reducing α-Synuclein and Inflammatory Responses in Motor Neurons After Spinal Cord Ischemia.Neurochemical research, , Volume: 46, Issue:12, 2021
The Intersection of Parkinson's Disease, Viral Infections, and COVID-19.Molecular neurobiology, , Volume: 58, Issue:9, 2021
Fatal attraction - The role of hypoxia when alpha-synuclein gets intimate with mitochondria.Neurobiology of aging, , Volume: 107, 2021
Genetic and Environmental Factors in Parkinson's Disease Converge on Immune Function and Inflammation.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:1, 2021
The Contribution of Microglia to Neuroinflammation in Parkinson's Disease.International journal of molecular sciences, , Apr-28, Volume: 22, Issue:9, 2021
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disease.International journal of molecular sciences, , Nov-10, Volume: 21, Issue:22, 2020
Modeling Parkinson's Disease Neuropathology and Symptoms by Intranigral Inoculation of Preformed Human α-Synuclein Oligomers.International journal of molecular sciences, , Nov-12, Volume: 21, Issue:22, 2020
Parkinson's disease and the gastrointestinal microbiome.Journal of neurology, , Volume: 267, Issue:9, 2020
Korean Red Ginseng Regulates Intestinal Tight Junction and Inflammation in the Colon of a Parkinson's Disease Mouse Model.Journal of medicinal food, , Volume: 23, Issue:12, 2020
Effects of Grape Polyphenols on the Life Span and Neuroinflammatory Alterations Related to Neurodegenerative Parkinson Disease-Like Disturbances in Mice.Molecules (Basel, Switzerland), , Nov-16, Volume: 25, Issue:22, 2020
The Role of α-Synuclein Oligomers in Parkinson's Disease.International journal of molecular sciences, , Nov-17, Volume: 21, Issue:22, 2020
CMT-3 targets different α-synuclein aggregates mitigating their toxic and inflammogenic effects.Scientific reports, , 11-20, Volume: 10, Issue:1, 2020
Biomarkers for Parkinson's Disease: How Good Are They?Neuroscience bulletin, , Volume: 36, Issue:2, 2020
A new avenue for treating Parkinson's disease targeted at aggrephagy modulation and neuroinflammation: Insights from in vitro and animal studies.EBioMedicine, , Volume: 51, 2020
Double-stranded RNA-induced dopaminergic neuronal loss in the substantia nigra in the presence of Mac1 receptor.Biochemical and biophysical research communications, , 12-17, Volume: 533, Issue:4, 2020
Preferential microglial activation associated with pathological alpha synuclein transmission.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, , Volume: 81, 2020
High-salt diet does not boost neuroinflammation and neurodegeneration in a model of α-synucleinopathy.Journal of neuroinflammation, , Jan-24, Volume: 17, Issue:1, 2020
Neuron-Astrocyte Interactions in Parkinson's Disease.Cells, , 12-07, Volume: 9, Issue:12, 2020
Immunotherapy for Parkinson's disease.Neurobiology of disease, , Volume: 137, 2020
Bioluminescence Imaging of Neuroinflammation in a Mouse Model of Parkinson's Disease.Methods in molecular biology (Clifton, N.J.), , Volume: 2081, 2020
Iron Dysregulation and Inflammagens Related to Oral and Gut Health Are Central to the Development of Parkinson's Disease.Biomolecules, , 12-29, Volume: 11, Issue:1, 2020
Gut Microbiome Imbalance and Neuroinflammation: Impact of COVID-19 on Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:9, 2020
What and How Can Physical Activity Prevention Function on Parkinson's Disease?Oxidative medicine and cellular longevity, , Volume: 2020, 2020
The Promise and Challenges of Developing miRNA-Based Therapeutics for Parkinson's Disease.Cells, , 03-31, Volume: 9, Issue:4, 2020
Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD.Proceedings of the National Academy of Sciences of the United States of America, , 06-30, Volume: 117, Issue:26, 2020
A novel multi-marker discovery approach identifies new serum biomarkers for Parkinson's disease in older people: an EXosomes in PArkiNson Disease (EXPAND) ancillary study.GeroScience, , Volume: 42, Issue:5, 2020
Apoptosis signal regulating kinase 1 deletion mitigates α-synuclein pre-formed fibril propagation in mice.Neurobiology of aging, , Volume: 85, 2020
The gut microbiome in Parkinson's disease: A culprit or a bystander?Progress in brain research, , Volume: 252, 2020
Mechanisms of alpha-synuclein toxicity: An update and outlook.Progress in brain research, , Volume: 252, 2020
Discoidin Domain Receptor 1 is a therapeutic target for neurodegenerative diseases.Human molecular genetics, , 10-10, Volume: 29, Issue:17, 2020
Biological links between traumatic brain injury and Parkinson's disease.Acta neuropathologica communications, , 04-07, Volume: 8, Issue:1, 2020
FTY720-Mitoxy reduces synucleinopathy and neuroinflammation, restores behavior and mitochondria function, and increases GDNF expression in Multiple System Atrophy mouse models.Experimental neurology, , Volume: 325, 2020
Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models.Journal of neuroinflammation, , Jul-17, Volume: 17, Issue:1, 2020
Alpha sinuclein expression in blood and its relationship with chronic constipation in a population from Bogotá, D.C., with problems of alcohol consumptionBiomedica : revista del Instituto Nacional de Salud, , 06-15, Volume: 40, Issue:2, 2020
Manganese Accumulation in the Brain via Various Transporters and Its Neurotoxicity Mechanisms.Molecules (Basel, Switzerland), , Dec-12, Volume: 25, Issue:24, 2020
Isotope-reinforced polyunsaturated fatty acids improve Parkinson's disease-like phenotype in rats overexpressing α-synuclein.Acta neuropathologica communications, , 12-11, Volume: 8, Issue:1, 2020
Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease.The Journal of clinical investigation, , 08-03, Volume: 130, Issue:8, 2020
Prodromal Intestinal Events in Alzheimer's Disease (AD): Colonic Dysmotility and Inflammation Are Associated with Enteric AD-Related Protein Deposition.International journal of molecular sciences, , May-15, Volume: 21, Issue:10, 2020
Novel Immunotherapeutic Approaches to Target Alpha-Synuclein and Related Neuroinflammation in Parkinson's Disease.Cells, , 01-31, Volume: 8, Issue:2, 2019
Histamine-4 receptor antagonist JNJ7777120 inhibits pro-inflammatory microglia and prevents the progression of Parkinson-like pathology and behaviour in a rat model.Brain, behavior, and immunity, , Volume: 76, 2019
CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson's disease.Journal of neuroinflammation, , Dec-12, Volume: 16, Issue:1, 2019
Temporal evolution of microglia and α-synuclein accumulation following foetal grafting in Parkinson's disease.Brain : a journal of neurology, , 06-01, Volume: 142, Issue:6, 2019
Lentivirus-mediated downregulation of α-synuclein reduces neuroinflammation and promotes functional recovery in rats with spinal cord injury.Journal of neuroinflammation, , Dec-30, Volume: 16, Issue:1, 2019
[Research progress on neural mechanism of peripheral inflammation in Parkinson's disease].Sheng li xue bao : [Acta physiologica Sinica], , Oct-25, Volume: 71, Issue:5, 2019
Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils.Neurobiology of disease, , Volume: 129, 2019
Nurr1: A vital participant in the TLR4-NF-κB signal pathway stimulated by α-synuclein in BV-2 cells.Neuropharmacology, , Volume: 144, 2019
Lycopodium Attenuates Loss of Dopaminergic Neurons by Suppressing Oxidative Stress and Neuroinflammation in a Rat Model of Parkinson's Disease.Molecules (Basel, Switzerland), , Jun-10, Volume: 24, Issue:11, 2019
Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson's disease.Nature communications, , 09-02, Volume: 10, Issue:1, 2019
Acute inflammation down-regulates alpha-synuclein expression in enteric neurons.Journal of neurochemistry, , Volume: 148, Issue:6, 2019
Calpain in the cleavage of alpha-synuclein and the pathogenesis of Parkinson's disease.Progress in molecular biology and translational science, , Volume: 167, 2019
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis.Acta neuropathologica, , Volume: 137, Issue:1, 2019
TLR4 absence reduces neuroinflammation and inflammasome activation in Parkinson's diseases in vivo model.Brain, behavior, and immunity, , Volume: 76, 2019
miR-let-7a suppresses α-Synuclein-induced microglia inflammation through targeting STAT3 in Parkinson's disease.Biochemical and biophysical research communications, , 11-19, Volume: 519, Issue:4, 2019
Exosomes from patients with Parkinson's disease are pathological in mice.Journal of molecular medicine (Berlin, Germany), , Volume: 97, Issue:9, 2019
Parkinson's disease: a short story of 200 years.Histology and histopathology, , Volume: 34, Issue:6, 2019
Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson's disease.Journal of neuroinflammation, , Jul-22, Volume: 16, Issue:1, 2019
Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease.Annals of neurology, , Volume: 86, Issue:4, 2019
Peripheral Inflammation Regulates CNS Immune Surveillance Through the Recruitment of Inflammatory Monocytes Upon Systemic α-Synuclein Administration.Frontiers in immunology, , Volume: 10, 2019
TREM2 deficiency aggravates α-synuclein-induced neurodegeneration and neuroinflammation in Parkinson's disease models.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 33, Issue:11, 2019
Microglia in Parkinson's Disease.Advances in experimental medicine and biology, , Volume: 1175, 2019
Autoimmunity in Parkinson's Disease: The Role of α-Synuclein-Specific T Cells.Frontiers in immunology, , Volume: 10, 2019
[no title available]Science translational medicine, , 09-25, Volume: 11, Issue:511, 2019
Aquaporin-4 deficiency reduces TGF-β1 in mouse midbrains and exacerbates pathology in experimental Parkinson's disease.Journal of cellular and molecular medicine, , Volume: 23, Issue:4, 2019
Alternative hypotheses related to Alzheimer's disease.Bratislavske lekarske listy, , Volume: 119, Issue:4, 2018
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Seipin deficiency in mice causes loss of dopaminergic neurons via aggregation and phosphorylation of α-synuclein and neuroinflammation.Cell death & disease, , 05-01, Volume: 9, Issue:5, 2018
Modulatory Role of Nurr1 Activation and Thrombin Inhibition in the Neuroprotective Effects of Dabigatran Etexilate in Rotenone-Induced Parkinson's Disease in Rats.Molecular neurobiology, , Volume: 55, Issue:5, 2018
Linking Neuroinflammation and Neurodegeneration in Parkinson's Disease.Journal of immunology research, , Volume: 2018, 2018
Motor neuron loss and neuroinflammation in a model of α-synuclein-induced neurodegeneration.Neurobiology of disease, , Volume: 120, 2018
Inflammation kinase PKR phosphorylates α-synuclein and causes α-synuclein-dependent cell death.Neurobiology of disease, , Volume: 115, 2018
Heat shock protein 70 suppresses neuroinflammation induced by α-synuclein in astrocytes.Molecular and cellular neurosciences, , Volume: 86, 2018
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Updates on immunity and inflammation in Parkinson disease pathology.Journal of neuroscience research, , Volume: 96, Issue:3, 2018
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Trichloroethylene and Parkinson's Disease: Risk Assessment.Molecular neurobiology, , Volume: 55, Issue:7, 2018
Neuroprotective Effects of Filgrastim in Rotenone-Induced Parkinson's Disease in Rats: Insights into its Anti-Inflammatory, Neurotrophic, and Antiapoptotic Effects.Molecular neurobiology, , Volume: 55, Issue:8, 2018
2-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease.Molecular neurobiology, , Volume: 55, Issue:12, 2018
Nurr1 overexpression exerts neuroprotective and anti-inflammatory roles via down-regulating CCL2 expression in both in vivo and in vitro Parkinson's disease models.Biochemical and biophysical research communications, , Jan-22, Volume: 482, Issue:4, 2017
Non-Amyloid PET Imaging Biomarkers for Neurodegeneration: Focus on Tau, Alpha-Synuclein and Neuroinflammation.Current Alzheimer research, , Volume: 14, Issue:2, 2017
The implication of neuronimmunoendocrine (NIE) modulatory network in the pathophysiologic process of Parkinson's disease.Cellular and molecular life sciences : CMLS, , Volume: 74, Issue:20, 2017
Toll-like receptor 2 is increased in neurons in Parkinson's disease brain and may contribute to alpha-synuclein pathology.Acta neuropathologica, , Volume: 133, Issue:2, 2017
Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production.Cellular and molecular life sciences : CMLS, , Volume: 74, Issue:15, 2017
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Alpha-Synuclein to the Rescue: Immune Cell Recruitment by Alpha-Synuclein during Gastrointestinal Infection.Journal of innate immunity, , Volume: 9, Issue:5, 2017
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Microglia in dementia with Lewy bodies.Brain, behavior, and immunity, , Volume: 55, 2016
6-Mer Hyaluronan Oligosaccharides Modulate Neuroinflammation and α-Synuclein Expression in Neuron-Like SH-SY5Y Cells.Journal of cellular biochemistry, , Volume: 117, Issue:12, 2016
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Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease.Cell, , Dec-01, Volume: 167, Issue:6, 2016
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Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model by targeting α-synuclein abnormalities in the substantia nigra.Toxicology letters, , Jan-22, Volume: 243, 2016
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Defects in trafficking bridge Parkinson's disease pathology and genetics.Nature, , 11-10, Volume: 539, Issue:7628, 2016
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Brain-gut-microbiota axis in Parkinson's disease.World journal of gastroenterology, , Oct-07, Volume: 21, Issue:37, 2015
Amyloid fibrils are the molecular trigger of inflammation in Parkinson's disease.The Biochemical journal, , Nov-01, Volume: 471, Issue:3, 2015
Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice.Molecular neurodegeneration, , Jul-30, Volume: 10, 2015
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FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease.Neurobiology of aging, , Volume: 36, Issue:3, 2015
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Inflammation induces multinucleation of Microglia via PKC inhibition of cytokinesis, generating highly phagocytic multinucleated giant cells.Journal of neurochemistry, , Volume: 128, Issue:5, 2014
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Impaired olfactory bulb neurogenesis depends on the presence of human wild-type alpha-synuclein.Neuroscience, , Oct-11, Volume: 222, 2012
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[New perspectives on the mechanism of methamphetamine-induced neurotoxicity].Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, , Volume: 28, Issue:2, 2008
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SGTA associates with intracellular aggregates in neurodegenerative diseases.Molecular brain, , 03-23, Volume: 14, Issue:1, 2021
The Alpha-Synuclein RT-QuIC Products Generated by the Olfactory Mucosa of Patients with Parkinson's Disease and Multiple System Atrophy Induce Inflammatory Responses in SH-SY5Y Cells.Cells, , 12-28, Volume: 11, Issue:1, 2021
Copper Dependent Modulation of α-Synuclein Phosphorylation in Differentiated SHSY5Y Neuroblastoma Cells.International journal of molecular sciences, , Feb-18, Volume: 22, Issue:4, 2021
Ghrelin protects against rotenone-induced cytotoxicity: Involvement of mitophagy and the AMPK/SIRT1/PGC1α pathway.Neuropeptides, , Volume: 87, 2021
Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells.Communications biology, , 05-21, Volume: 4, Issue:1, 2021
Conformational distortion in a fibril-forming oligomer arrests alpha-Synuclein fibrillation and minimizes its toxic effects.Communications biology, , 05-03, Volume: 4, Issue:1, 2021
Kaempferol Has Potent Protective and Antifibrillogenic Effects for α-Synuclein Neurotoxicity In Vitro.International journal of molecular sciences, , Oct-25, Volume: 22, Issue:21, 2021
Abnormal accumulation of lipid droplets in neurons induces the conversion of alpha-Synuclein to proteolytic resistant forms in a Drosophila model of Parkinson's disease.PLoS genetics, , Volume: 17, Issue:11, 2021
Misfolded α-synuclein causes hyperactive respiration without functional deficit in live neuroblastoma cells.Disease models & mechanisms, , 01-17, Volume: 13, Issue:1, 2020
Changes in the cellular fatty acid profile drive the proteasomal degradation of α-synuclein and enhance neuronal survival.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 34, Issue:11, 2020
Real-Time Characterization of Cell Membrane Disruption by α-Synuclein Oligomers in Live SH-SY5Y Neuroblastoma Cells.ACS chemical neuroscience, , 09-02, Volume: 11, Issue:17, 2020
P2X7 Receptor is Involved in Mitochondrial Dysfunction Induced by Extracellular Alpha Synuclein in Neuroblastoma SH-SY5Y Cells.International journal of molecular sciences, , May-31, Volume: 21, Issue:11, 2020
Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor.International journal of molecular sciences, , Jul-22, Volume: 21, Issue:15, 2020
α-Synuclein Overexpression in SH-SY5Y Human Neuroblastoma Cells Leads to the Accumulation of Thioflavin S-positive Aggregates and Impairment of Glycolysis.Biochemistry. Biokhimiia, , Volume: 85, Issue:5, 2020
α-synuclein accumulation in SH-SY5Y cell impairs autophagy in microglia by exosomes overloading miR-19a-3p.Epigenomics, , 11-01, Volume: 11, Issue:15, 2019
Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase.Proceedings of the National Academy of Sciences of the United States of America, , 10-08, Volume: 116, Issue:41, 2019
Increased Aggregation Tendency of Alpha-Synuclein in a Fully Disordered Protein Complex.Journal of molecular biology, , 06-28, Volume: 431, Issue:14, 2019
Involvement of C/EBPβ-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis.Toxicology letters, , Sep-15, Volume: 312, 2019
Conformational-Switch Based Strategy Triggered by [18] π Heteroannulenes toward Reduction of Alpha Synuclein Oligomer Toxicity.ACS chemical neuroscience, , 01-16, Volume: 10, Issue:1, 2019
A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body-like pathology.Science translational medicine, , 06-05, Volume: 11, Issue:495, 2019
Cell-Based Screen Using Amyloid Mimic β23 Expression Identifies Peucedanocoumarin III as a Novel Inhibitor of α-Synuclein and Huntingtin Aggregates.Molecules and cells, , Jun-30, Volume: 42, Issue:6, 2019
Upregulation of the p53-p21 pathway by G2019S LRRK2 contributes to the cellular senescence and accumulation of α-synuclein.Cell cycle (Georgetown, Tex.), , Volume: 18, Issue:4, 2019
Efficient Detection of Early Events of α-Synuclein Aggregation Using a Cysteine Specific Hybrid Scaffold.Biochemistry, , 02-26, Volume: 58, Issue:8, 2019
Glycosaminoglycans have variable effects on α-synuclein aggregation and differentially affect the activities of the resulting amyloid fibrils.The Journal of biological chemistry, , 08-24, Volume: 293, Issue:34, 2018
Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods.Acta neuropathologica communications, , 04-18, Volume: 6, Issue:1, 2018
Extracellular α-Synuclein Disrupts Membrane Nanostructure and Promotes S-Nitrosylation-Induced Neuronal Cell Death.Biomacromolecules, , 04-09, Volume: 19, Issue:4, 2018
Co-aggregation of pro-inflammatory S100A9 with α-synuclein in Parkinson's disease: ex vivo and in vitro studies.Journal of neuroinflammation, , Jun-04, Volume: 15, Issue:1, 2018
Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity.Acta neuropathologica communications, , 07-02, Volume: 6, Issue:1, 2018
Extracellular α-synuclein drives sphingosine 1-phosphate receptor subtype 1 out of lipid rafts, leading to impaired inhibitory G-protein signaling.The Journal of biological chemistry, , 05-25, Volume: 293, Issue:21, 2018
Complexation of NAC-Derived Peptide Ligands with the C-Terminus of α-Synuclein Accelerates Its Aggregation.Biochemistry, , 02-06, Volume: 57, Issue:5, 2018
The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity.The Journal of biological chemistry, , 03-23, Volume: 293, Issue:12, 2018
Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons.Proceedings of the National Academy of Sciences of the United States of America, , 10-09, Volume: 115, Issue:41, 2018
Real-time determination of aggregated alpha-synuclein induced membrane disruption at neuroblastoma cells using scanning ion conductance microscopy.Faraday discussions, , 10-01, Volume: 210, Issue:0, 2018
An Inducible Alpha-Synuclein Expressing Neuronal Cell Line Model for Parkinson's Disease1.Journal of Alzheimer's disease : JAD, , Volume: 66, Issue:2, 2018
Influence of Early Life Lead (Pb) Exposure on α-Synuclein, GSK-3β and Caspase-3 Mediated Tauopathy: Implications on Alzheimer's Disease.Current Alzheimer research, , Volume: 15, Issue:12, 2018
Calcipotriol inhibits α-synuclein aggregation in SH-SY5Y neuroblastoma cells by a Calbindin-D28k-dependent mechanism.Journal of neurochemistry, , Volume: 141, Issue:2, 2017
Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation.Journal of neuroinflammation, , 08-02, Volume: 14, Issue:1, 2017
Mitochondrial ferritin protects SH-SY5Y cells against HExperimental neurology, , Volume: 291, 2017
Discoidin domain receptor inhibition reduces neuropathology and attenuates inflammation in neurodegeneration models.Journal of neuroimmunology, , 10-15, Volume: 311, 2017
Ginkgolide B and bilobalide ameliorate neural cell apoptosis in α-synuclein aggregates.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 96, 2017
Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson's Disease.Journal of Alzheimer's disease : JAD, , Volume: 60, Issue:s1, 2017
Individual Amino Acid Supplementation Can Improve Energy Metabolism and Decrease ROS Production in Neuronal Cells Overexpressing Alpha-Synuclein.Neuromolecular medicine, , Volume: 19, Issue:2-3, 2017
Levodopa (L-DOPA) attenuates endoplasmic reticulum stress response and cell death signaling through DRD2 in SH-SY5Y neuronal cells under α-synuclein-induced toxicity.Neuroscience, , 09-01, Volume: 358, 2017
Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy.Neurobiology of disease, , Volume: 104, 2017
Impairment of mitochondria dynamics by human A53T α-synuclein and rescue by NAP (davunetide) in a cell model for Parkinson's disease.Experimental brain research, , Volume: 235, Issue:3, 2017
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.Proceedings of the National Academy of Sciences of the United States of America, , 02-07, Volume: 114, Issue:6, 2017
Elevated levels of alpha-synuclein blunt cellular signal transduction downstream of Gq protein-coupled receptors.Cellular signalling, , Volume: 30, 2017
Neuronal hemoglobin in mitochondria is reduced by forming a complex with α-synuclein in aging monkey brains.Oncotarget, , Feb-16, Volume: 7, Issue:7, 2016
Influence of 6-Hydroxydopamine Toxicity on α-Synuclein Phosphorylation, Resting Vesicle Expression, and Vesicular Dopamine Release.Journal of cellular biochemistry, , Volume: 117, Issue:12, 2016
Cellular response of human neuroblastoma cells to α-synuclein fibrils, the main constituent of Lewy bodies.Biochimica et biophysica acta, , Volume: 1860, Issue:1 Pt A, 2016
α-Synuclein enhances histone H3 lysine-9 dimethylation and H3K9me2-dependent transcriptional responses.Scientific reports, , 11-03, Volume: 6, 2016
Direct Observation of α-Synuclein Amyloid Aggregates in Endocytic Vesicles of Neuroblastoma Cells.PloS one, , Volume: 11, Issue:4, 2016
Rotenone down-regulates HSPA8/hsc70 chaperone protein in vitro: A new possible toxic mechanism contributing to Parkinson's disease.Neurotoxicology, , Volume: 54, 2016
High expression of α-synuclein in damaged mitochondria with PLA2G6 dysfunction.Acta neuropathologica communications, , Mar-30, Volume: 4, 2016
Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 07-20, Volume: 36, Issue:29, 2016
6-Mer Hyaluronan Oligosaccharides Modulate Neuroinflammation and α-Synuclein Expression in Neuron-Like SH-SY5Y Cells.Journal of cellular biochemistry, , Volume: 117, Issue:12, 2016
Suppression of MAPK attenuates neuronal cell death induced by activated glia-conditioned medium in alpha-synuclein overexpressing SH-SY5Y cells.Journal of neuroinflammation, , Oct-26, Volume: 12, 2015
Proteasome subunit and opioid receptor gene expression down-regulation induced by paraquat and maneb in human neuroblastoma SH-SY5Y cells.Environmental toxicology and pharmacology, , Volume: 40, Issue:3, 2015
MicroRNA-214 participates in the neuroprotective effect of Resveratrol via inhibiting α-synuclein expression in MPTP-induced Parkinson's disease mouse.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 74, 2015
Heat shock protein 70 induction by glutamine increases the α-synuclein degradation in SH-SY5Y neuroblastoma cells.Molecular medicine reports, , Volume: 12, Issue:4, 2015
Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration.Molecular neurodegeneration, , 06-23, Volume: 10, 2015
A cell culture model for monitoring α-synuclein cell-to-cell transfer.Neurobiology of disease, , Volume: 77, 2015
Molecular determinants of α-synuclein mutants' oligomerization and membrane interactions.ACS chemical neuroscience, , Mar-18, Volume: 6, Issue:3, 2015
Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways.Neurobiology of disease, , Volume: 81, 2015
Over-expression of an inactive mutant cathepsin D increases endogenous alpha-synuclein and cathepsin B activity in SH-SY5Y cells.Journal of neurochemistry, , Volume: 128, Issue:6, 2014
The protective role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro.Neurobiology of disease, , Volume: 63, 2014
Modulation of human α-synuclein aggregation by a combined effect of calcium and dopamine.Neurobiology of disease, , Volume: 63, 2014
5-S-cysteinyldopamine neurotoxicity: Influence on the expression of α-synuclein and ERp57 in cellular and animal models of Parkinson's disease.Journal of neuroscience research, , Volume: 92, Issue:3, 2014
Dopamine and Cu+/2+ can induce oligomerization of α-synuclein in the absence of oxygen: Two types of oligomerization mechanisms for α-synuclein and related cell toxicity studies.Journal of neuroscience research, , Volume: 92, Issue:3, 2014
Prefoldin prevents aggregation of α-synuclein.Brain research, , Jan-13, Volume: 1542, 2014
ATP6V0C knockdown in neuroblastoma cells alters autophagy-lysosome pathway function and metabolism of proteins that accumulate in neurodegenerative disease.PloS one, , Volume: 9, Issue:4, 2014
The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells.Human molecular genetics, , Sep-01, Volume: 23, Issue:17, 2014
Accumulation of α-synuclein in dementia with Lewy bodies is associated with decline in the α-synuclein-degrading enzymes kallikrein-6 and calpain-1.Acta neuropathologica communications, , Dec-05, Volume: 2, 2014
Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:12, 2014
Amyloid-β oligomers as a template for secondary amyloidosis in Alzheimer's disease.Neurobiology of disease, , Volume: 71, 2014
Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease.The EMBO journal, , Nov-27, Volume: 32, Issue:23, 2013
Endonuclease-G and the pathways to dopaminergic neurodegeneration: a question of location?The EMBO journal, , Nov-27, Volume: 32, Issue:23, 2013
G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome.Annals of neurology, , Volume: 73, Issue:4, 2013
Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration.Brain : a journal of neurology, , Volume: 136, Issue:Pt 7, 2013
In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells.The Journal of biological chemistry, , Mar-01, Volume: 288, Issue:9, 2013
Specific pesticide-dependent increases in α-synuclein levels in human neuroblastoma (SH-SY5Y) and melanoma (SK-MEL-2) cell lines.Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 133, Issue:2, 2013
P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Aug-22, Volume: 32, Issue:34, 2012
Extracellular signal-regulated kinase is involved in alpha-synuclein-induced mitochondrial dynamic disorders by regulating dynamin-like protein 1.Neurobiology of aging, , Volume: 33, Issue:12, 2012
Changes in sphingomyelin level affect alpha-synuclein and ABCA5 expression.Journal of Parkinson's disease, , Volume: 2, Issue:1, 2012
α-synuclein phosphorylation and truncation are normal events in the adult human brain.Neuroscience, , Jan-03, Volume: 200, 2012
α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases.Journal of neurochemistry, , Volume: 120, Issue:3, 2012
Moracenin D from Mori Cortex radicis protects SH-SY5Y cells against dopamine-induced cell death by regulating nurr1 and α-synuclein expression.Phytotherapy research : PTR, , Volume: 26, Issue:4, 2012
Effects of intravenous immunoglobulin on alpha synuclein aggregation and neurotoxicity.International immunopharmacology, , Volume: 14, Issue:4, 2012
Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains.Annals of neurology, , Volume: 72, Issue:3, 2012
Neuroprotective effects of 3α-acetoxyeudesma-1,4(15),11(13)-trien-12,6α-olide against dopamine-induced apoptosis in the human neuroblastoma SH-SY5Y cell line.Neurochemical research, , Volume: 36, Issue:11, 2011
N-terminal deletion does not affect α-synuclein membrane binding, self-association and toxicity in human neuroblastoma cells, unlike yeast.Journal of neurochemistry, , Volume: 119, Issue:2, 2011
Dopamine and paraquat enhance α-synuclein-induced alterations in membrane conductance.Neurotoxicity research, , Volume: 20, Issue:4, 2011
α-Synuclein aggregation and transmission are enhanced by leucine-rich repeat kinase 2 in human neuroblastoma SH-SY5Y cells.Biological & pharmaceutical bulletin, , Volume: 34, Issue:7, 2011
The oxysterol 27-hydroxycholesterol regulates α-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors--relevance to Parkinson's disease.Journal of neurochemistry, , Volume: 119, Issue:5, 2011
Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-17, Volume: 30, Issue:7, 2010
Differential effects of wild-type and A53T mutant isoform of alpha-synuclein on the mitochondrial proteome of differentiated SH-SY5Y cells.Journal of proteome research, , May-07, Volume: 9, Issue:5, 2010
Alpha-synuclein overexpression increases dopamine toxicity in BE2-M17 cells.BMC neuroscience, , Mar-25, Volume: 11, 2010
G protein-coupled receptor kinase 5, overexpressed in the alpha-synuclein up-regulation model of Parkinson's disease, regulates bcl-2 expression.Brain research, , Jan-11, Volume: 1307, 2010
Dual effects of alpha-synuclein on neurotoxicity induced by low dosage of rotenone are dependent on exposure time in dopaminergic neuroblastoma cells.Science China. Life sciences, , Volume: 53, Issue:5, 2010
Filamentous phages reduce alpha-synuclein oligomerization in the membrane fraction of SH-SY5Y cells.Neuro-degenerative diseases, , Volume: 7, Issue:1-3, 2010
Genome-wide microarray analysis of the differential neuroprotective effects of antioxidants in neuroblastoma cells overexpressing the familial Parkinson's disease alpha-synuclein A53T mutation.Neurochemical research, , Volume: 35, Issue:1, 2010
Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival.The Journal of neuroscience : the official journal of the Society for Neuroscience, , May-19, Volume: 30, Issue:20, 2010
Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells.The international journal of biochemistry & cell biology, , Volume: 41, Issue:10, 2009
Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies.The American journal of pathology, , Volume: 174, Issue:5, 2009
alpha-Synuclein modulation of Ca2+ signaling in human neuroblastoma (SH-SY5Y) cells.Journal of neurochemistry, , Volume: 111, Issue:5, 2009
The Parkinson disease-associated A30P mutation stabilizes alpha-synuclein against proteasomal degradation triggered by heme oxygenase-1 over-expression in human neuroblastoma cells.Journal of neurochemistry, , Volume: 110, Issue:2, 2009
Parkin attenuates wild-type tau modification in the presence of beta-amyloid and alpha-synuclein.Journal of molecular neuroscience : MN, , Volume: 37, Issue:1, 2009
Microarray expression analysis of human dopaminergic neuroblastoma cells after RNA interference of SNCA--a key player in the pathogenesis of Parkinson's disease.Brain research, , Feb-23, Volume: 1256, 2009
Inducible over-expression of wild type alpha-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death.Journal of neurochemistry, , Volume: 109, Issue:5, 2009
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation.The Journal of clinical investigation, , Volume: 119, Issue:3, 2009
Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism.Neurotoxicology, , Volume: 30, Issue:6, 2009
Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux.Journal of neurochemistry, , Volume: 108, Issue:6, 2009
The ubiquitin ligase E6-AP promotes degradation of alpha-synuclein.Journal of neurochemistry, , Volume: 110, Issue:6, 2009
Curcumin inhibits aggregation of alpha-synuclein.Acta neuropathologica, , Volume: 115, Issue:4, 2008
Aggregates assembled from overexpression of wild-type alpha-synuclein are not toxic to human neuronal cells.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:11, 2008
Regulation of alpha-synuclein expression by liver X receptor ligands in vitro.Neuroreport, , Nov-19, Volume: 19, Issue:17, 2008
Advanced glycation end products induce in vitro cross-linking of alpha-synuclein and accelerate the process of intracellular inclusion body formation.Journal of neuroscience research, , Volume: 86, Issue:9, 2008
Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and alpha-synuclein in human neuroblastoma SH-SY5Y cells.Journal of neurochemistry, , Volume: 107, Issue:6, 2008
Differences between normal and alpha-synuclein overexpressing SH-SY5Y neuroblastoma cells after Abeta(1-42) and NAC treatment.Brain research bulletin, , Mar-28, Volume: 75, Issue:5, 2008
High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in a Drosophila model of Parkinson's disease.Journal of neuroscience research, , Volume: 86, Issue:9, 2008
Cyclooxygenase-2 is involved in oxidative damage and alpha-synuclein accumulation in dopaminergic cells.Neuroscience letters, , May-09, Volume: 436, Issue:2, 2008
Melatonin inhibits amphetamine-induced increase in alpha-synuclein and decrease in phosphorylated tyrosine hydroxylase in SK-N-SH cells.Neuroscience letters, , May-16, Volume: 436, Issue:3, 2008
Nurr1 transcriptionally regulates the expression of alpha-synuclein.Neuroreport, , May-28, Volume: 19, Issue:8, 2008
Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-28, Volume: 27, Issue:48, 2007
Different species of alpha-synuclein oligomers induce calcium influx and seeding.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Aug-22, Volume: 27, Issue:34, 2007
The novel squamosamide derivative (compound FLZ) attenuated 1-methyl, 4-phenyl-pyridinium ion (MPP+)-induced apoptosis and alternations of related signal transduction in SH-SY5Y cells.Neuropharmacology, , Volume: 52, Issue:2, 2007
RNA interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from MPP(+) toxicity and reduces dopamine transport.Journal of neuroscience research, , Feb-01, Volume: 85, Issue:2, 2007
Alpha-synuclein overexpression reduces gap junctional intercellular communication in dopaminergic neuroblastoma cells.Neuroscience letters, , Apr-18, Volume: 416, Issue:3, 2007
Assembly of lysine 63-linked ubiquitin conjugates by phosphorylated alpha-synuclein implies Lewy body biogenesis.The Journal of biological chemistry, , May-11, Volume: 282, Issue:19, 2007
A cell-based model of alpha-synucleinopathy for screening compounds with therapeutic potential of Parkinson's disease.Acta pharmacologica Sinica, , Volume: 28, Issue:5, 2007
Zinc protects SK-N-SH cells from methamphetamine-induced alpha-synuclein expression.Neuroscience letters, , May-23, Volume: 419, Issue:1, 2007
Cellular oligomerization of alpha-synuclein is determined by the interaction of oxidized catechols with a C-terminal sequence.The Journal of biological chemistry, , Oct-26, Volume: 282, Issue:43, 2007
Lack of direct role of parkin in the steady-state level and aggregation of alpha-synuclein and the clearance of pre-formed aggregates.Experimental neurology, , Volume: 197, Issue:2, 2006
The alpha-synuclein mutation E46K promotes aggregation in cultured cells.Experimental neurology, , Volume: 197, Issue:2, 2006
6-Hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation.The Journal of biological chemistry, , Apr-07, Volume: 281, Issue:14, 2006
Proteasomal inhibition hypersensitizes differentiated neuroblastoma cells to oxidative damage.Neuroscience letters, , May-15, Volume: 399, Issue:1-2, 2006
Small molecule inhibitors of alpha-synuclein filament assembly.Biochemistry, , May-16, Volume: 45, Issue:19, 2006
alpha-Synuclein protects SH-SY5Y cells from dopamine toxicity.Biochemical and biophysical research communications, , Nov-03, Volume: 349, Issue:4, 2006
The neurotoxin, MPP+, induces hyperphosphorylation of Tau, in the presence of alpha-Synuclein, in SH-SY5Y neuroblastoma cells.Neurotoxicity research, , Volume: 10, Issue:1, 2006
Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Sep-27, Volume: 26, Issue:39, 2006
Common anti-apoptotic roles of parkin and alpha-synuclein in human dopaminergic cells.Biochemical and biophysical research communications, , Jun-24, Volume: 332, Issue:1, 2005
Selenomethionine prevents degeneration induced by overexpression of wild-type human alpha-synuclein during differentiation of neuroblastoma cells.Journal of the American College of Nutrition, , Volume: 24, Issue:6, 2005
Induction of C/EBP beta and GADD153 expression by dopamine in human neuroblastoma cells. Relationship with alpha-synuclein increase and cell damage.Brain research bulletin, , Feb-15, Volume: 65, Issue:1, 2005
Alpha-synuclein up-regulation and aggregation during MPP+-induced apoptosis in neuroblastoma cells: intermediacy of transferrin receptor iron and hydrogen peroxide.The Journal of biological chemistry, , Apr-09, Volume: 279, Issue:15, 2004
Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-25, Volume: 24, Issue:8, 2004
alpha-Synuclein selectively increases manganese-induced viability loss in SK-N-MC neuroblastoma cells expressing the human dopamine transporter.Neuroscience letters, , Jan-02, Volume: 354, Issue:1, 2004
Parkinson's disease transgenic mitochondrial cybrids generate Lewy inclusion bodies.Journal of neurochemistry, , Volume: 88, Issue:4, 2004
Tissue transglutaminase is not involved in the aggregate formation of stably expressed alpha-synuclein in SH-SY5Y human neuroblastoma cells.Archives of pharmacal research, , Volume: 27, Issue:8, 2004
Accelerated alpha-synuclein aggregation after differentiation of SH-SY5Y neuroblastoma cells.Brain research, , Jul-02, Volume: 1013, Issue:1, 2004
A strategy for designing inhibitors of alpha-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 18, Issue:11, 2004
Differential cytotoxicity of human wild type and mutant alpha-synuclein in human neuroblastoma SH-SY5Y cells in the presence of dopamine.Biochemistry, , May-11, Volume: 43, Issue:18, 2004
1-Benzyl-1,2,3,4-tetrahydroisoquinoline, a Parkinsonism-inducing endogenous toxin, increases alpha-synuclein expression and causes nuclear damage in human dopaminergic cells.Journal of neuroscience research, , May-15, Volume: 76, Issue:4, 2004
Overexpression of alpha-synuclein decreased viability and enhanced sensitivity to prostaglandin E(2), hydrogen peroxide, and a nitric oxide donor in differentiated neuroblastoma cells.Journal of neuroscience research, , May-01, Volume: 76, Issue:3, 2004
Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function.The Journal of biological chemistry, , Apr-04, Volume: 278, Issue:14, 2003
Polymorphisms of the alpha-synuclein promoter: expression analyses and association studies in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 110, Issue:1, 2003
Fe(II)-induced DNA damage in alpha-synuclein-transfected human dopaminergic BE(2)-M17 neuroblastoma cells: detection by the Comet assay.Journal of neurochemistry, , Volume: 87, Issue:3, 2003
Alpha-synuclein up-regulates expression of caveolin-1 and down-regulates extracellular signal-regulated kinase activity in B103 neuroblastoma cells: role in the pathogenesis of Parkinson's disease.Journal of neurochemistry, , Volume: 85, Issue:6, 2003
Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of alpha-synuclein.Brain pathology (Zurich, Switzerland), , Volume: 13, Issue:3, 2003
Functional analysis of intra-allelic variation at NACP-Rep1 in the alpha-synuclein gene.Human genetics, , Volume: 113, Issue:5, 2003
Dopamine induces autophagic cell death and alpha-synuclein increase in human neuroblastoma SH-SY5Y cells.Journal of neuroscience research, , Aug-01, Volume: 73, Issue:3, 2003
Differential cytotoxicity of dopamine and H2O2 in a human neuroblastoma divided cell line transfected with alpha-synuclein and its familial Parkinson's disease-linked mutants.Neuroscience letters, , May-15, Volume: 342, Issue:1-2, 2003
Co-ordinate transcriptional regulation of dopamine synthesis genes by alpha-synuclein in human neuroblastoma cell lines.Journal of neurochemistry, , Volume: 85, Issue:4, 2003
MPP+ increases alpha-synuclein expression and ERK/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cells.Brain research, , May-10, Volume: 935, Issue:1-2, 2002
Synphilin-1 degradation by the ubiquitin-proteasome pathway and effects on cell survival.Journal of neurochemistry, , Volume: 83, Issue:2, 2002
Deferoxamine attenuates iron-induced oxidative stress and prevents mitochondrial aggregation and alpha-synuclein translocation in SK-N-SH cells in culture.Developmental neuroscience, , Volume: 24, Issue:2-3, 2002
An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Aug-15, Volume: 22, Issue:16, 2002
Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult.Journal of neurochemistry, , Volume: 76, Issue:4, 2001
The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Aug-15, Volume: 20, Issue:16, 2000
alpha-Synuclein is expressed in a variety of brain tumors showing neuronal differentiation.Acta neuropathologica, , Volume: 99, Issue:2, 2000
Enhanced vulnerability to oxidative stress by alpha-synuclein mutations and C-terminal truncation.Neuroscience, , Volume: 97, Issue:2, 2000
Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments.FEBS letters, , Nov-27, Volume: 440, Issue:1-2, 1998
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Autophagy-lysosome pathway alterations and alpha-synuclein up-regulation in the subtype of neuronal ceroid lipofuscinosis, CLN5 disease.Scientific reports, , 01-17, Volume: 9, Issue:1, 2019
Hereditary Parkinsonism-Associated Genetic Variations in PARK9 Locus Lead to Functional Impairment of ATPase Type 13A2.Current protein & peptide science, , Volume: 18, Issue:7, 2017
Altered levels of α-synuclein and sphingolipids in Batten disease lymphoblast cells.Gene, , Apr-15, Volume: 539, Issue:2, 2014
Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits.Human molecular genetics, , May-15, Volume: 22, Issue:10, 2013
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A Randomized First-in-Human Study With UB-312, a UBITh® α-Synuclein Peptide Vaccine.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:7, 2022
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Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds.Acta neuropathologica communications, , 11-24, Volume: 9, Issue:1, 2021
Neuroinvasion of α-Synuclein Prionoids after Intraperitoneal and Intraglossal Inoculation.Journal of virology, , 10-15, Volume: 90, Issue:20, 2016
Familial and sporadic Parkinson's disease usually display the same clinical features.Parkinsonism & related disorders, , Volume: 9, Issue:4, 2003
Total Glucosides of White Paeony Capsule ameliorates Parkinson's disease-like behavior in MPTP-induced mice model by regulating LRRK2/alpha-synuclein signaling.Journal of ethnopharmacology, , Jan-30, Volume: 319, Issue:Pt 2, 2024
Functional and Pathological Effects of α-Synuclein on Synaptic SNARE Complexes.Journal of molecular biology, , 01-15, Volume: 435, Issue:1, 2023
Liquid-liquid Phase Separation of α-Synuclein: A New Mechanistic Insight for α-Synuclein Aggregation Associated with Parkinson's Disease Pathogenesis.Journal of molecular biology, , 01-15, Volume: 435, Issue:1, 2023
Structural Insights of FeJournal of molecular biology, , 01-15, Volume: 435, Issue:1, 2023
Curcumin-loaded human endometrial stem cells derived exosomes as an effective carrier to suppress alpha-synuclein aggregates in 6OHDA-induced Parkinson's disease mouse model.Cell and tissue banking, , Volume: 24, Issue:1, 2023
Phosphorylated α-synuclein in skin Schwann cells: a new biomarker for multiple system atrophy.Brain : a journal of neurology, , 03-01, Volume: 146, Issue:3, 2023
Mendelian Randomization Analysis Reveals No Causal Relationship Between Plasma α-Synuclein and Parkinson's Disease.Molecular neurobiology, , Volume: 60, Issue:4, 2023
A Comprehensive Study of miRNAs in Parkinson's Disease: Diagnostics and Therapeutic Approaches.CNS & neurological disorders drug targets, , Volume: 22, Issue:3, 2023
Sensitive electrochemical recognition of α-synuclein protein in human plasma samples using bioconjugated gold nanoparticles: An innovative immuno-platform to assist in the early stage identification of Parkinson's disease by biosensor technology.Journal of molecular recognition : JMR, , Volume: 36, Issue:4, 2023
Immunotherapeutic Approaches for the Treatment of Neurodegenerative Diseases: Challenges and Outcomes.CNS & neurological disorders drug targets, , Volume: 22, Issue:3, 2023
MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson's disease.Molecular neurodegeneration, , Dec-01, Volume: 18, Issue:1, 2023
Enhanced mTORC1 signaling and protein synthesis in pathologic α-synuclein cellular and animal models of Parkinson's disease.Science translational medicine, , Nov-29, Volume: 15, Issue:724, 2023
Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson's disease in rodent brains.Molecular neurodegeneration, , Nov-27, Volume: 18, Issue:1, 2023
aSynPEP-DB: a database of biogenic peptides for inhibiting α-synuclein aggregation.Database : the journal of biological databases and curation, , 11-27, Volume: 2023, 2023
[no title available]Gut microbes, , Volume: 15, Issue:2, 2023
Nucleation of α-Synuclein Amyloid Fibrils Induced by Cross-Interaction with β-Hairpin Peptides Derived from Immunoglobulin Light Chains.International journal of molecular sciences, , Nov-09, Volume: 24, Issue:22, 2023
Neuronal SNCA transcription during Lewy body formation.Acta neuropathologica communications, , 11-23, Volume: 11, Issue:1, 2023
Brain-to-gut trafficking of alpha-synuclein by CD11cNature communications, , Nov-20, Volume: 14, Issue:1, 2023
Polymorphic USP8 allele promotes Parkinson's disease by inducing the accumulation of α-synuclein through deubiquitination.Cellular and molecular life sciences : CMLS, , Nov-19, Volume: 80, Issue:12, 2023
Anionic nanoplastic contaminants promote Parkinson's disease-associated α-synuclein aggregation.Science advances, , 11-15, Volume: 9, Issue:46, 2023
Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores.Journal of the American Chemical Society, , Nov-29, Volume: 145, Issue:47, 2023
Anethole attenuates motor dysfunctions, striatal neuronal activity deficiency and blood brain barrier permeability by decreasing striatal α-synuclein and oxidative stress in rotenone-induced Parkinson's disease of male rats.PloS one, , Volume: 18, Issue:11, 2023
Polysorbate 80 surface modified SLNs of formoterol suppress SNCA gene and mitochondrial oxidative stress in mice model of Parkinson's disease.Scientific reports, , 11-15, Volume: 13, Issue:1, 2023
Co-aggregation of α-synuclein with amyloid-β stabilizes β-sheet-rich oligomers and enhances the formation of β-barrels.Physical chemistry chemical physics : PCCP, , Nov-29, Volume: 25, Issue:46, 2023
Transmembrane β-Barrel Models of α-Synuclein Oligomers.Journal of chemical information and modeling, , Nov-27, Volume: 63, Issue:22, 2023
Photo-oxygenation of histidine residue inhibits α-synuclein aggregation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 37, Issue:12, 2023
Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson's disease mouse model.Nature communications, , 11-13, Volume: 14, Issue:1, 2023
Formoterol attenuated mitochondrial dysfunction in rotenone-induced Parkinson's disease in a rat model: Role of PINK-1/PARKIN and PI3K/Akt/CREB/BDNF/TrKB axis.International immunopharmacology, , Volume: 125, Issue:Pt B, 2023
Probing physical properties of single amyloid fibrils using nanofluidic channels.Nanoscale, , Nov-30, Volume: 15, Issue:46, 2023
Aggregation of alpha-synuclein disrupts mitochondrial metabolism and induce mitophagy via cardiolipin externalization.Cell death & disease, , 11-10, Volume: 14, Issue:11, 2023
Single-Molecule Detection of α-Synuclein Oligomers in Parkinson's Disease Patients Using Nanopores.ACS nano, , 11-28, Volume: 17, Issue:22, 2023
Peptide-based approaches to directly target alpha-synuclein in Parkinson's disease.Molecular neurodegeneration, , Nov-09, Volume: 18, Issue:1, 2023
Cholestanol accelerates α-synuclein aggregation and spreading by activating asparagine endopeptidase.JCI insight, , Nov-08, Volume: 8, Issue:21, 2023
Characterization of Molecular Tweezer Binding on α-Synuclein with Native Top-Down Mass Spectrometry and Ion Mobility-Mass Spectrometry Reveals a Mechanism for Aggregation Inhibition.Journal of the American Society for Mass Spectrometry, , Dec-06, Volume: 34, Issue:12, 2023
Antagonizing pathological α-synuclein-mediated neurodegeneration by J24335 via the activation of immunoproteasome.Toxicology and applied pharmacology, , Dec-01, Volume: 480, 2023
Distinct molecular mechanisms contribute to the reduction of melanoma growth and tumor pain after systemic and local depletion of alpha-Synuclein in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 37, Issue:12, 2023
Synaptotagmin-11 regulates immune functions of microglia in vivo.Journal of neurochemistry, , Volume: 167, Issue:5, 2023
Conformational dynamics of α-synuclein and study of its intramolecular forces in the presence of selected compounds.Scientific reports, , 11-03, Volume: 13, Issue:1, 2023
SARS-CoV-2 N-protein induces the formation of composite α-synuclein/N-protein fibrils that transform into a strain of α-synuclein fibrils.Nanoscale, , Nov-23, Volume: 15, Issue:45, 2023
[no title available]Biomolecular NMR assignments, , Volume: 17, Issue:2, 2023
Modulation of Alpha-Synuclein Conformational Ensemble and Aggregation Pathways by Dopamine and Related Molecules.Frontiers in bioscience (Landmark edition), , 10-26, Volume: 28, Issue:10, 2023
The yeast prion protein Sup35 initiates α-synuclein pathology in mouse models of Parkinson's disease.Science advances, , 11-03, Volume: 9, Issue:44, 2023
Alpha-Synuclein-Specific Regulatory T Cells Ameliorate Parkinson's Disease Progression in Mice.International journal of molecular sciences, , Oct-16, Volume: 24, Issue:20, 2023
The Effects of Lipids on α-Synuclein Aggregation In Vitro.Biomolecules, , 10-02, Volume: 13, Issue:10, 2023
Autophagy in Parkinson's Disease.Biomolecules, , 09-22, Volume: 13, Issue:10, 2023
The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases.Nature communications, , 10-27, Volume: 14, Issue:1, 2023
Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering.Proceedings of the National Academy of Sciences of the United States of America, , Oct-31, Volume: 120, Issue:44, 2023
Citrus Flavonoid Hesperetin Inhibits α-Synuclein Fibrillogenesis, Disrupts Mature Fibrils, and Reduces Their Cytotoxicity: In Vitro and In Vivo Studies.Journal of agricultural and food chemistry, , Nov-01, Volume: 71, Issue:43, 2023
Dynamic reversibility of α-synuclein serine-129 phosphorylation is impaired in synucleinopathy models.EMBO reports, , Dec-06, Volume: 24, Issue:12, 2023
Tau accumulation in degradative organelles is associated to lysosomal stress.Scientific reports, , 10-21, Volume: 13, Issue:1, 2023
α-synuclein seed amplification in Parkinson's disease.The Lancet. Neurology, , Volume: 22, Issue:11, 2023
α-synuclein seed amplification in Parkinson's disease - Authors' reply.The Lancet. Neurology, , Volume: 22, Issue:11, 2023
α-synuclein seed amplification in Parkinson's disease.The Lancet. Neurology, , Volume: 22, Issue:11, 2023
α-synuclein seed amplification in Parkinson's disease.The Lancet. Neurology, , Volume: 22, Issue:11, 2023
Oligomeric and Fibrillar α-Synuclein Display Persistent Dynamics and Compressibility under Controlled Confinement.ACS chemical neuroscience, , 11-01, Volume: 14, Issue:21, 2023
Synuclein Seed Amplification in the Cerebrospinal Fluid: Research and Clinical Implications.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:11, 2023
Identifying Current pharmaceutical design, , Volume: 29, Issue:30, 2023
Inactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson's disease.Scientific reports, , 10-18, Volume: 13, Issue:1, 2023
The interplay between α-Synuclein and NLRP3 inflammasome in Parkinson's disease.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 168, 2023
α-Synuclein propagation leads to synaptic abnormalities in the cortex through microglial synapse phagocytosis.Molecular brain, , 10-17, Volume: 16, Issue:1, 2023
Lipoproteins and α-synuclein in cerebrospinal fluid in Parkinson's disease: "Dangerous liaisons" on the road to neurodegeneration?Parkinsonism & related disorders, , Volume: 116, 2023
The interaction between alpha-synuclein and mitochondrial dysfunction in Parkinson's disease.Biophysical chemistry, , Volume: 303, 2023
α-Synuclein-dependent increases in PIP5K1γ drive inositol signaling to promote neurotoxicity.Cell reports, , 10-31, Volume: 42, Issue:10, 2023
Retinal Changes in Parkinson's Disease: A Non-invasive Biomarker for Early Diagnosis.Cellular and molecular neurobiology, , Volume: 43, Issue:8, 2023
Kinetic parameters of alpha-synuclein seed amplification assay correlate with cognitive impairment in patients with Lewy body disorders.Acta neuropathologica communications, , 10-09, Volume: 11, Issue:1, 2023
Measuring Constipation in a Drosophila Model of Parkinson's Disease.Journal of visualized experiments : JoVE, , 09-22, Issue:199, 2023
Identifying the potential genes in alpha synuclein driving ferroptosis of Parkinson's disease.Scientific reports, , 10-06, Volume: 13, Issue:1, 2023
Feasibility of combining alpha-synuclein aggregation and 6-OHDA in embryonic midbrain culture for modeling dopamine neuron degeneration.Neuroscience letters, , 11-01, Volume: 816, 2023
Misfolded α-Synuclein in Cerebrospinal Fluid of Contact Sport Athletes.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:11, 2023
α-Synuclein induces deficiency in clathrin-mediated endocytosis through inhibiting synaptojanin1 expression.Journal of neurochemistry, , Volume: 167, Issue:3, 2023
Nanowired delivery of dl-3-n-butylphthalide with antibodies to alpha synuclein potentiated neuroprotection in Parkinson's disease with emotional stress.International review of neurobiology, , Volume: 171, 2023
Imaging Protein Aggregates in Parkinson's Disease Serum Using Aptamer-Assisted Single-Molecule Pull-Down.Analytical chemistry, , 10-17, Volume: 95, Issue:41, 2023
Stable isotope labeling and ultra-high-resolution NanoSIMS imaging reveal alpha-synuclein-induced changes in neuronal metabolism in vivo.Acta neuropathologica communications, , 09-29, Volume: 11, Issue:1, 2023
Neuromelanin accumulation drives endogenous synucleinopathy in non-human primates.Brain : a journal of neurology, , Dec-01, Volume: 146, Issue:12, 2023
A Novel NOX Inhibitor Alleviates Parkinson's Disease Pathology in PFF-Injected Mice.International journal of molecular sciences, , Sep-19, Volume: 24, Issue:18, 2023
The Avidity of Autoreactive Alpha-Synuclein Antibodies in Leucine-Rich Repeat Kinase 2 Mutation Carriers Is Not Altered Compared to Healthy Controls or Patients with Parkinson's Disease.Biomolecules, , 08-25, Volume: 13, Issue:9, 2023
Syringin Prevents 6-Hydroxydopamine Neurotoxicity by Mediating the MiR-34a/SIRT1/Beclin-1 Pathway and Activating Autophagy in SH-SY5Y Cells and the Cells, , 09-19, Volume: 12, Issue:18, 2023
Nuclear localization of alpha-synuclein induces anxiety-like behavior in mice by decreasing hippocampal neurogenesis and pathologically affecting amygdala circuits.Neuroscience letters, , 11-01, Volume: 816, 2023
Ferroptosis in Parkinson's disease: Molecular mechanisms and therapeutic potential.Ageing research reviews, , Volume: 91, 2023
Peptide immunization against the C-terminal of alpha-synuclein reduces locomotor activity in mice overexpressing alpha-synuclein.PloS one, , Volume: 18, Issue:9, 2023
The neuroprotective effects of FG-4592, a hypoxia-inducible factor-prolyl hydroxylase inhibitor, against oxidative stress induced by alpha-synuclein in N2a cells.Scientific reports, , 09-20, Volume: 13, Issue:1, 2023
The C-terminus of α-Synuclein Regulates its Dynamic Cellular Internalization by Neurexin 1β.Molecular biology of the cell, , Dec-01, Volume: 34, Issue:13, 2023
A fruit extract of Styphnolobium japonicum (L.) counteracts oxidative stress and mediates neuroprotection in Caenorhabditis elegans.BMC complementary medicine and therapies, , Sep-19, Volume: 23, Issue:1, 2023
Investigating the potential effects of α-synuclein aggregation on susceptibility to chronic stress in a mouse Parkinson's disease model.Pharmacological reports : PR, , Volume: 75, Issue:6, 2023
Elevated concentrations cause upright alpha-synuclein conformation at lipid interfaces.Nature communications, , 09-18, Volume: 14, Issue:1, 2023
Low-dose Cu exposure enhanced α-synuclein accumulation associates with mitochondrial impairments in mice model of Parkinson's disease.Toxicology letters, , Sep-15, Volume: 387, 2023
Viral-like TLR3 induction of cytokine networks and α-synuclein are reduced by complement C3 blockade in mouse brain.Scientific reports, , 09-13, Volume: 13, Issue:1, 2023
Cross-Linked α-Synuclein as Inhibitor of Amyloid Formation.International journal of molecular sciences, , Aug-29, Volume: 24, Issue:17, 2023
Uncovering the Role of Natural and Synthetic Small Molecules in Counteracting the Burden of α-Synuclein Aggregates and Related Toxicity in Different Models of Parkinson's Disease.International journal of molecular sciences, , Aug-29, Volume: 24, Issue:17, 2023
The Bidirectional Interplay of α-Synuclein with Lipids in the Central Nervous System and Its Implications for the Pathogenesis of Parkinson's Disease.International journal of molecular sciences, , Aug-26, Volume: 24, Issue:17, 2023
Beyond Strains: Molecular Diversity in Alpha-Synuclein at the Center of Disease Heterogeneity.International journal of molecular sciences, , Aug-25, Volume: 24, Issue:17, 2023
TFEB regulates cellular labile iron and prevents ferroptosis in a TfR1-dependent manner.Free radical biology & medicine, , 11-01, Volume: 208, 2023
6-hydroxydopamine affects multiple pathways to induce cytotoxicity in differentiated LUHMES dopaminergic neurons.Neurochemistry international, , Volume: 170, 2023
Fiber deprivation and microbiome-borne curli shift gut bacterial populations and accelerate disease in a mouse model of Parkinson's disease.Cell reports, , 09-26, Volume: 42, Issue:9, 2023
A small molecule 20C from Gastrodia elata inhibits α-synuclein aggregation and prevents progression of Parkinson's disease.Cell death & disease, , 09-06, Volume: 14, Issue:9, 2023
A selective ER-phagy exerts neuroprotective effects via modulation of α-synuclein clearance in parkinsonian models.Proceedings of the National Academy of Sciences of the United States of America, , 09-12, Volume: 120, Issue:37, 2023
Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease.Journal of cellular and molecular medicine, , Volume: 27, Issue:22, 2023
Structure specific neuro-toxicity of α-synuclein oligomer.International journal of biological macromolecules, , Dec-31, Volume: 253, Issue:Pt 1, 2023
Monovalent cations have different effects on the assembly kinetics and morphology of α-synuclein amyloid fibrils.Biochemical and biophysical research communications, , 10-30, Volume: 679, 2023
A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibrils in Multiple System Atrophy.Journal of medicinal chemistry, , 09-14, Volume: 66, Issue:17, 2023
Association between regular physical activity and biomarker changes in early Parkinson's disease patients.Parkinsonism & related disorders, , Volume: 115, 2023
Distinct impacts of alpha-synuclein overexpression on the hippocampal epigenome of mice in standard and enriched environments.Neurobiology of disease, , 10-01, Volume: 186, 2023
Distinct Patterns of Gene Expression Changes in the Colon and Striatum of Young Mice Overexpressing Alpha-Synuclein Support Parkinson's Disease as a Multi-System Process.Journal of Parkinson's disease, , Volume: 13, Issue:7, 2023
Association between SGK1 and α-synuclein in skeletal muscle in an MPTP-induced Parkinson's disease model.Neuroscience letters, , 09-25, Volume: 814, 2023
Amyloids of α-Synuclein Promote Chemical Transformations of Neuronal Cell Metabolites.International journal of molecular sciences, , Aug-16, Volume: 24, Issue:16, 2023
Aggregation-Inhibiting scFv-Based Therapies Protect Mice against AAV1/2-Induced A53T-α-Synuclein Overexpression.Biomolecules, , 07-31, Volume: 13, Issue:8, 2023
Membrane phospholipid peroxidation promotes loss of dopaminergic neurons in psychological stress-induced Parkinson's disease susceptibility.Aging cell, , Volume: 22, Issue:10, 2023
α-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis.Translational neurodegeneration, , 08-25, Volume: 12, Issue:1, 2023
Calcineurin stimulation by Cnb1p overproduction mitigates protein aggregation and α-synuclein toxicity in a yeast model of synucleinopathy.Cell communication and signaling : CCS, , 08-24, Volume: 21, Issue:1, 2023
Fiber-Specific White Matter Alterations in Parkinson's Disease Patients with GBA Gene Mutations.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:11, 2023
Meta-analysis to Implement Alpha-Synuclein in Extracellular Vesicles as a Potential Biomarker for Parkinsons Disease.Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion, , Volume: 75, Issue:4, 2023
Developmental exposure to the Parkinson's disease-associated organochlorine pesticide dieldrin alters dopamine neurotransmission in α-synuclein pre-formed fibril (PFF)-injected mice.Toxicological sciences : an official journal of the Society of Toxicology, , Oct-30, Volume: 196, Issue:1, 2023
Effects of ozone treatment to the levels of neurodegeneration biomarkers after rotenone induced rat model of Parkinson's disease.Neuroscience letters, , 09-25, Volume: 814, 2023
The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis.Molecular medicine (Cambridge, Mass.), , 08-18, Volume: 29, Issue:1, 2023
27-Hydroxycholesterol Drives the Spread of α-Synuclein Pathology in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:11, 2023
Seed amplification assay results illustrate discrepancy in Parkinson's disease clinical diagnostic accuracy and error rates.Journal of neurology, , Volume: 270, Issue:12, 2023
Mutant α-synuclein propagates via the lymphatic system of the brain in the monomeric state.Cell reports, , 08-29, Volume: 42, Issue:8, 2023
A Fixable Fluorescence-Quenched Substrate for Quantitation of Lysosomal Glucocerebrosidase Activity in Both Live and Fixed Cells.Angewandte Chemie (International ed. in English), , 10-02, Volume: 62, Issue:40, 2023
Coumarin-chalcone hybrid LM-021 and indole derivative NC009-1 targeting inflammation and oxidative stress to protect BE(2)-M17 cells against α-synuclein toxicity.Aging, , 08-11, Volume: 15, Issue:16, 2023
Effect of flavonoids on the destabilization of α-synuclein fibrils and their conversion to amorphous aggregate: A molecular dynamics simulation and experimental study.Biochimica et biophysica acta. Proteins and proteomics, , 11-01, Volume: 1871, Issue:6, 2023
Comparison of biospecimens for α-synuclein seed amplification assays in Parkinson's disease: A systematic review and network meta-analysis.European journal of neurology, , Volume: 30, Issue:12, 2023
Acetylated α-Tubulin and α-Synuclein: Physiological Interplay and Contribution to α-Synuclein Oligomerization.International journal of molecular sciences, , Jul-31, Volume: 24, Issue:15, 2023
α-Synuclein Strains and Their Relevance to Parkinson's Disease, Multiple System Atrophy, and Dementia with Lewy Bodies.International journal of molecular sciences, , Jul-28, Volume: 24, Issue:15, 2023
Investigation of Inflammation in Lewy Body Dementia: A Systematic Scoping Review.International journal of molecular sciences, , Jul-28, Volume: 24, Issue:15, 2023
Neuroprotective effects of osmotin in Parkinson's disease-associated pathology via the AdipoR1/MAPK/AMPK/mTOR signaling pathways.Journal of biomedical science, , Aug-11, Volume: 30, Issue:1, 2023
The variance in phosphorylated, insoluble ⍺-synuclein in humans, rats, and mice is not mainly driven by biological sex.Acta neuropathologica, , Volume: 146, Issue:4, 2023
Implications of In Vitro Multi-Serine Phosphorylation of Alpha-Synuclein in Aggregation and Cytotoxicity.ACS chemical neuroscience, , 09-06, Volume: 14, Issue:17, 2023
Combined measure of salivary alpha-synuclein species as diagnostic biomarker for Parkinson's disease.Journal of neurology, , Volume: 270, Issue:11, 2023
Combining non-canonical amino acid mutagenesis and native chemical ligation for multiply modifying proteins: A case study of α-synuclein post-translational modifications.Methods (San Diego, Calif.), , Volume: 218, 2023
Understanding the effect of the membrane-mimetic micelles on the interplay between α-synuclein and Cu(II)/Cu(I) cations.Journal of inorganic biochemistry, , Volume: 247, 2023
VPS35 and α-Synuclein fail to interact to modulate neurodegeneration in rodent models of Parkinson's disease.Molecular neurodegeneration, , 08-04, Volume: 18, Issue:1, 2023
How should we be using biomarkers in trials of disease modification in Parkinson's disease?Brain : a journal of neurology, , Dec-01, Volume: 146, Issue:12, 2023
Combating Dopaminergic Neurodegeneration in Parkinson's Disease through Nanovesicle Technology.ACS chemical neuroscience, , 08-16, Volume: 14, Issue:16, 2023
The Involvement of Progranulin for α-Synuclein Reduction through Autolysosome Formation.Biological & pharmaceutical bulletin, , Volume: 46, Issue:8, 2023
Omics Analyses in a Neural Stem Cell Model of Familial Parkinson's Disease.Advances in experimental medicine and biology, , Volume: 1423, 2023
Non-invasive Monitoring of α-Synuclein in Saliva for Parkinson's Disease Using Organic Electrolyte-Gated FET Aptasensor.ACS sensors, , 08-25, Volume: 8, Issue:8, 2023
Pharmacological interventions targeting α-synuclein aggregation triggered REM sleep behavior disorder and early development of Parkinson's disease.Pharmacology & therapeutics, , Volume: 249, 2023
E46K Mutation of α-Synuclein Preorganizes the Intramolecular Interactions Crucial for Aggregation.Journal of chemical information and modeling, , 08-14, Volume: 63, Issue:15, 2023
Blood-Based α-Synuclein Seeding-A New Era for Identifying Parkinsonian Syndromes.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:8, 2023
Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer.Archives of biochemistry and biophysics, , Volume: 744, 2023
4-Oxo-2-nonenal-Induced α-Synuclein Oligomers Interact with Membranes in the Cell, Leading to Mitochondrial Fragmentation.Biochemistry, , 08-15, Volume: 62, Issue:16, 2023
Alpha-synuclein fibrils amplified from multiple system atrophy and Parkinson's disease patient brain spread after intracerebral injection into mouse brain.Brain pathology (Zurich, Switzerland), , Volume: 33, Issue:5, 2023
Co-administration of Nanowired DL-3-n-Butylphthalide (DL-NBP) Together with Mesenchymal Stem Cells, Monoclonal Antibodies to Alpha Synuclein and TDP-43 (TAR DNA-Binding Protein 43) Enhance Superior Neuroprotection in Parkinson's Disease Following ConcussiAdvances in neurobiology, , Volume: 32, 2023
Nanodelivery of Histamine H3/H4 Receptor Modulators BF-2649 and Clobenpropit with Antibodies to Amyloid Beta Peptide in Combination with Alpha Synuclein Reduces Brain Pathology in Parkinson's Disease.Advances in neurobiology, , Volume: 32, 2023
Elevated ApoE, ApoJ and lipoprotein-bound α-synuclein levels in cerebrospinal fluid from Parkinson's disease patients - Validation in the BioFIND cohort.Parkinsonism & related disorders, , Volume: 116, 2023
Lessons and future directions for GBA1-targeting therapies.The Lancet. Neurology, , Volume: 22, Issue:8, 2023
Alpha-synuclein in skin as a high-quality biomarker for Parkinson's disease.Journal of the neurological sciences, , 08-15, Volume: 451, 2023
Impaired aldehyde detoxification exacerbates motor deficits in an alpha-synuclein mouse model of Parkinson's disease.Brain and behavior, , Volume: 13, Issue:9, 2023
Parallel neurodegenerative phenotypes in sporadic Parkinson's disease fibroblasts and midbrain dopamine neurons.Progress in neurobiology, , Volume: 229, 2023
Extracellular Vesicles for the Diagnosis of Parkinson's Disease: Systematic Review and Meta-Analysis.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:9, 2023
Are Therapies That Target α-Synuclein Effective at Halting Parkinson's Disease Progression? A Systematic Review.International journal of molecular sciences, , Jul-03, Volume: 24, Issue:13, 2023
Brain-Biomarker Changes in Body Fluids of Patients with Parkinson's Disease.International journal of molecular sciences, , Jun-30, Volume: 24, Issue:13, 2023
Probing Gut Participation in Parkinson's Disease Pathology and Treatment via Stem Cell Therapy.International journal of molecular sciences, , Jun-25, Volume: 24, Issue:13, 2023
ARL6IP5 Ameliorates α-Synuclein Burden by Inducing Autophagy via Preventing Ubiquitination and Degradation of ATG12.International journal of molecular sciences, , Jun-22, Volume: 24, Issue:13, 2023
IL-1β/IL-1R1 signaling is involved in the propagation of α-synuclein pathology of the gastrointestinal tract to the brain.Journal of neurochemistry, , Volume: 166, Issue:5, 2023
How oxidized EGCG remodels α-synuclein fibrils into non-toxic aggregates: insights from computational simulations.Physical chemistry chemical physics : PCCP, , Jul-19, Volume: 25, Issue:28, 2023
Gut-to-brain spreading of pathology in synucleinopathies: A focus on molecular signalling mediators.Behavioural brain research, , 08-24, Volume: 452, 2023
More than meets the eye in Parkinson's disease and other synucleinopathies: from proteinopathy to lipidopathy.Acta neuropathologica, , Volume: 146, Issue:3, 2023
SYNJ1 rescues motor functions in hereditary and sporadic Parkinson's disease mice by upregulating TSP-1 expression.Behavioural brain research, , 08-24, Volume: 452, 2023
Evaluation of α-synuclein in CNS-originating extracellular vesicles for Parkinsonian disorders: A systematic review and meta-analysis.CNS neuroscience & therapeutics, , Volume: 29, Issue:12, 2023
The investigation of interaction and chaperon-like activity of α-synuclein as a protein in pathophysiology of Parkinson's disease upon direct interaction with tectorigenin.International journal of biological macromolecules, , Sep-30, Volume: 249, 2023
SARS-COV-2 spike protein fragment eases amyloidogenesis of α-synuclein.The Journal of chemical physics, , Jul-07, Volume: 159, Issue:1, 2023
Toll-like Receptor 4 Is Upregulated in Parkinson's Disease Patients and Co-Localizes with pSer129αSyn: A Possible Link with the Pathology.Cells, , 05-11, Volume: 12, Issue:10, 2023
Intramolecular interaction kinetically regulates fibril formation by human and mouse α-synuclein.Scientific reports, , 07-05, Volume: 13, Issue:1, 2023
Hippocampal synaptic failure is an early event in experimental parkinsonism with subtle cognitive deficit.Brain : a journal of neurology, , Dec-01, Volume: 146, Issue:12, 2023
Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease.Molecular neurodegeneration, , 07-04, Volume: 18, Issue:1, 2023
Collaborative plasma biomarkers for Parkinson disease development and progression: A cross-sectional and longitudinal study.European journal of neurology, , Volume: 30, Issue:10, 2023
Seed Amplification Assay as a Diagnostic Tool in Newly-Diagnosed Parkinson's Disease.Journal of Parkinson's disease, , Volume: 13, Issue:5, 2023
Endocytic pathways of pathogenic protein aggregates in neurodegenerative diseases.Traffic (Copenhagen, Denmark), , Volume: 24, Issue:10, 2023
α-Synuclein seeding activity in duodenum biopsies from Parkinson's disease patients.PLoS pathogens, , Volume: 19, Issue:6, 2023
Discrimination between Alpha-Synuclein Protein Variants with a Single Nanometer-Scale Pore.ACS chemical neuroscience, , 07-19, Volume: 14, Issue:14, 2023
Sex and Age Differences in a Progressive Synucleinopathy Mouse Model.Biomolecules, , 06-11, Volume: 13, Issue:6, 2023
Three-dimensional neuroimmune co-culture system for modeling Parkinson's disease microenvironmentsBiofabrication, , 07-10, Volume: 15, Issue:4, 2023
Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of Parkinson disease.Nature communications, , 06-26, Volume: 14, Issue:1, 2023
Parkinson's disease-linked V15A mutation facilitates α-synuclein aggregation by reducing membrane affinity.Protein science : a publication of the Protein Society, , Volume: 32, Issue:8, 2023
Ultrastiff Amyloid-Fibril Network of α-Synuclein Formed by Surface Seeding Reaction Confirmed by Multichannel Electrodeless Quartz-Crystal-Microbalance Biosensor.ACS sensors, , 07-28, Volume: 8, Issue:7, 2023
Targeted degradation of ⍺-synuclein aggregates in Parkinson's disease using the AUTOTAC technology.Molecular neurodegeneration, , Jun-24, Volume: 18, Issue:1, 2023
Pharmacologic inhibition of NLRP3 reduces the levels of α-synuclein and protects dopaminergic neurons in a model of Parkinson's disease.Journal of neuroinflammation, , Jun-22, Volume: 20, Issue:1, 2023
Nigral Pathology Contributes to Microstructural Integrity of Striatal and Frontal Tracts in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:9, 2023
Transcriptomic profiling of Parkinson's disease brains reveals disease stage specific gene expression changes.Acta neuropathologica, , Volume: 146, Issue:2, 2023
α-Synuclein and biological membranes: the danger of loving too much.Chemical communications (Cambridge, England), , Jul-13, Volume: 59, Issue:57, 2023
Advanced human iPSC-based preclinical model for Parkinson's disease with optogenetic alpha-synuclein aggregation.Cell stem cell, , Jul-06, Volume: 30, Issue:7, 2023
Mass photometric detection and quantification of nanoscale α-synuclein phase separation.Nature chemistry, , Volume: 15, Issue:9, 2023
Generation of TWO G51D SNCA missense mutation iPSC lines (CRICKi011-A, CRICKi012-A) from two individuals at risk of Parkinson's disease.Stem cell research, , Volume: 71, 2023
GM1 oligosaccharide efficacy against α-synuclein aggregation and toxicity in vitro.Biochimica et biophysica acta. Molecular and cell biology of lipids, , Volume: 1868, Issue:9, 2023
Simultaneous Determination of the Size and Shape of Single α-Synuclein Oligomers in Solution.ACS nano, , 07-11, Volume: 17, Issue:13, 2023
Semi-Synthetic CoA-α-Synuclein Constructs Trap N-Terminal Acetyltransferase NatB for Binding Mechanism Studies.Journal of the American Chemical Society, , 06-28, Volume: 145, Issue:25, 2023
Unveiling How Hydroxytyrosol Destabilizes α-Syn Oligomers Using Molecular Simulations.The journal of physical chemistry. B, , 06-29, Volume: 127, Issue:25, 2023
A 14-day pulse of PLX5622 modifies α-synucleinopathy in preformed fibril-infused aged mice of both sexes.Neurobiology of disease, , Volume: 184, 2023
The mitochondrial uncoupling effects of nitazoxanide enhances cellular autophagy and promotes the clearance of α-synuclein: Potential role of AMPK-JNK pathway.Cellular signalling, , Volume: 109, 2023
Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy models.Translational neurodegeneration, , 06-13, Volume: 12, Issue:1, 2023
METTL14 is decreased and regulates mJournal of neurochemistry, , Volume: 166, Issue:3, 2023
Unsaturated fatty acids uniquely alter aggregation rate of α-synuclein and insulin and change the secondary structure and toxicity of amyloid aggregates formed in their presence.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 37, Issue:7, 2023
Microglial LRRK2-mediated NFATc1 attenuates α-synuclein immunotoxicity in association with CX3CR1-induced migration and the lysosome-initiated degradation.Glia, , Volume: 71, Issue:9, 2023
Neutrophil-to-lymphocyte ratio and lymphocyte count reflect alterations in central neurodegeneration-associated proteins and clinical severity in Parkinson Disease patients.Parkinsonism & related disorders, , Volume: 112, 2023
Truncation or proteolysis of α-synuclein in Parkinsonism.Ageing research reviews, , Volume: 90, 2023
Parkinson's Disease: A Tale of Many Players.Medical principles and practice : international journal of the Kuwait University, Health Science Centre, , Volume: 32, Issue:3, 2023
The loss of function GBA1 c.231C > G mutation associated with Parkinson disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 130, Issue:7, 2023
Sortilin acts as an endocytic receptor for α-synuclein fibril.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 37, Issue:7, 2023
Single-cell transcriptomics identifies perturbed molecular pathways in midbrain organoids using α-synuclein triplication Parkinson's disease patient-derived iPSCs.Neuroscience research, , Volume: 195, 2023
Nigrostriatal 6-hydroxydopamine lesions increase alpha-synuclein levels and permeability in rat colon.Neurobiology of aging, , Volume: 129, 2023
RAGE Against the Glycation Machine in Synucleinopathies: Time to Explore New Questions.Journal of Parkinson's disease, , Volume: 13, Issue:5, 2023
Association of Cortical Gyrification With Imaging and Serum Biomarkers in Patients With Parkinson Disease.Neurology, , 07-18, Volume: 101, Issue:3, 2023
Single-dose intranasal administration of α-syn PFFs induce lewy neurite-like pathology in olfactory bulbs.Parkinsonism & related disorders, , Volume: 112, 2023
Alpha-synuclein-associated changes in PINK1-PRKN-mediated mitophagy are disease context dependent.Brain pathology (Zurich, Switzerland), , Volume: 33, Issue:5, 2023
Targeting Sigma-1 Receptor: A Promising Strategy in the Treatment of Parkinson's Disease.Neurochemical research, , Volume: 48, Issue:10, 2023
Necrosulfonamide exerts neuroprotective effect by inhibiting necroptosis, neuroinflammation, and α-synuclein oligomerization in a subacute MPTP mouse model of Parkinson's disease.Scientific reports, , 05-31, Volume: 13, Issue:1, 2023
Disruption of α-Synuclein Proteostasis in the Striatum and Midbrain of Long-term Ovariectomized Female Mice.Neuroscience, , 07-15, Volume: 523, 2023
Dissecting the Self-assembly Dynamics of Imperfect Repeats in α-Synuclein.Journal of chemical information and modeling, , 06-12, Volume: 63, Issue:11, 2023
Phosphorylation of α-synuclein at T64 results in distinct oligomers and exerts toxicity in models of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 06-06, Volume: 120, Issue:23, 2023
Intestinal infection triggers mitochondria-mediated α-synuclein pathology: relevance to Parkinson's disease.Cellular and molecular life sciences : CMLS, , May-30, Volume: 80, Issue:6, 2023
Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α-Synuclein Mouse Models of Parkinson's Disease.Journal of medicinal chemistry, , 06-08, Volume: 66, Issue:11, 2023
Propagative α-synuclein seeds as serum biomarkers for synucleinopathies.Nature medicine, , Volume: 29, Issue:6, 2023
Parkinson's disease in a patient with olfactory hypoplasia: a model case of "body-first Lewy body disease" providing insights into the progression of α-synuclein accumulation.Journal of neurology, , Volume: 270, Issue:10, 2023
Alpha-synuclein and the Parkinson's disease drug pipeline.Parkinsonism & related disorders, , Volume: 111, 2023
Parkinson's Disease: Exploring Different Animal Model Systems.International journal of molecular sciences, , May-22, Volume: 24, Issue:10, 2023
Oligomeric Alpha-Synuclein and STX-1A from Neural-Derived Extracellular Vesicles (NDEVs) as Possible Biomarkers of REM Sleep Behavior Disorder in Parkinson's Disease: A Preliminary Cohort Study.International journal of molecular sciences, , May-16, Volume: 24, Issue:10, 2023
Asymmetric Presynaptic Depletion of Dopamine Neurons in a International journal of molecular sciences, , May-11, Volume: 24, Issue:10, 2023
Serum and Exosomal miR-7-1-5p and miR-223-3p as Possible Biomarkers for Parkinson's Disease.Biomolecules, , 05-19, Volume: 13, Issue:5, 2023
Distinct Effects of Familial Parkinson's Disease-Associated Mutations on α-Synuclein Phase Separation and Amyloid Aggregation.Biomolecules, , 04-23, Volume: 13, Issue:5, 2023
Generation of gene-corrected isogenic controls from Parkinson's disease patient iPSC lines carrying the pathogenic SNCA p.A53T variant.Stem cell research, , Volume: 69, 2023
Uncovering Novel Therapeutic Targets for Parkinson's Disease.ACS chemical neuroscience, , 06-07, Volume: 14, Issue:11, 2023
NF-κB/NLRP3 inflammasome axis and risk of Parkinson's disease in Type 2 diabetes mellitus: A narrative review and new perspective.Journal of cellular and molecular medicine, , Volume: 27, Issue:13, 2023
Retina-to-brain spreading of α-synuclein after intravitreal injection of preformed fibrils.Acta neuropathologica communications, , 05-20, Volume: 11, Issue:1, 2023
How Toll-like receptors influence Parkinson's disease in the microbiome-gut-brain axis.Frontiers in immunology, , Volume: 14, 2023
Galectin-3 shapes toxic alpha-synuclein strains in Parkinson's disease.Acta neuropathologica, , Volume: 146, Issue:1, 2023
Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity.PLoS genetics, , Volume: 19, Issue:5, 2023
Microglia-specific knock-out of NF-κB/IKK2 increases the accumulation of misfolded α-synuclein through the inhibition of p62/sequestosome-1-dependent autophagy in the rotenone model of Parkinson's disease.Glia, , Volume: 71, Issue:9, 2023
Research Progress of α-Synuclein Aggregation Inhibitors for Potential Parkinson's Disease Treatment.Mini reviews in medicinal chemistry, , Volume: 23, Issue:20, 2023
[no title available]Frontiers in cellular and infection microbiology, , Volume: 13, 2023
Impact of sex on neuroimmune contributions to Parkinson's disease.Brain research bulletin, , Volume: 199, 2023
Response to Comment on "Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice".Science translational medicine, , 05-17, Volume: 15, Issue:696, 2023
Naphthoquinone-dopamine hybrids disrupt α-synuclein fibrils by their intramolecular synergistic interactions with fibrils and display a better effect on fibril disruption.Physical chemistry chemical physics : PCCP, , May-24, Volume: 25, Issue:20, 2023
The α-Synuclein Monomer May Have Different Misfolding Mechanisms in the Induction of α-Synuclein Fibrils with Different Polymorphs.Biomolecules, , 04-17, Volume: 13, Issue:4, 2023
Alpha-Synuclein mRNA Level Found Dependent on L444P Variant in Carriers and Gaucher Disease Patients on Enzyme Replacement Therapy.Biomolecules, , 04-03, Volume: 13, Issue:4, 2023
A RaPID Macrocyclic Peptide That Inhibits the Formation of α-Synuclein Amyloid Fibrils.Chembiochem : a European journal of chemical biology, , 06-15, Volume: 24, Issue:12, 2023
Midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons.The Journal of clinical investigation, , 05-15, Volume: 133, Issue:10, 2023
Advances in understanding the function of alpha-synuclein: implications for Parkinson's disease.Brain : a journal of neurology, , 09-01, Volume: 146, Issue:9, 2023
Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats.Cell death & disease, , 05-13, Volume: 14, Issue:5, 2023
Synucleinopathies Take Their Toll: Are TLRs a Way to Go?Cells, , 04-24, Volume: 12, Issue:9, 2023
Neuropathology of incidental Lewy body & prodromal Parkinson's disease.Molecular neurodegeneration, , 05-12, Volume: 18, Issue:1, 2023
Retinoic Acid Prevents α-Synuclein Preformed Fibrils-Induced Toxicity via Inhibiting STAT1-PARP1 Signaling.Molecular neurobiology, , Volume: 60, Issue:8, 2023
The heterogeneity of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 130, Issue:6, 2023
Inhibition of p38α MAPK restores neuronal p38γ MAPK and ameliorates synaptic degeneration in a mouse model of DLB/PD.Science translational medicine, , 05-10, Volume: 15, Issue:695, 2023
Apoptotic Factors and Mitochondrial Complexes Assist Determination of Strain-Specific Susceptibility of Mice to Parkinsonian Neurotoxin MPTP.Molecular neurobiology, , Volume: 60, Issue:8, 2023
Dopamine-Induced Oligomers of α-Synuclein Inhibit Amyloid Fibril Growth and Show No Toxicity.ACS chemical neuroscience, , 06-07, Volume: 14, Issue:11, 2023
In situ continuous Dopa supply by responsive artificial enzyme for the treatment of Parkinson's disease.Nature communications, , 05-09, Volume: 14, Issue:1, 2023
An amphiphilic material arginine-arginine-bile acid promotes α-synuclein amyloid formation.Nanoscale, , Jun-01, Volume: 15, Issue:21, 2023
The Endotoxin Hypothesis of Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:7, 2023
Endophytic Fusarium species, a unique bioresource for disaggregator of misfolded alpha-synuclein.Archives of microbiology, , May-08, Volume: 205, Issue:6, 2023
Islet amyloid polypeptide triggers α-synuclein pathology in Parkinson's disease.Progress in neurobiology, , Volume: 226, 2023
The Endo-lysosomal System in Parkinson's Disease: Expanding the Horizon.Journal of molecular biology, , 06-15, Volume: 435, Issue:12, 2023
Impact of APOE Genotype on Cognition in Idiopathic and Genetic Forms of Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:5, 2023
Involvement of Abnormal p-α-syn Accumulation and TLR2-Mediated Inflammation of Schwann Cells in Enteric Autonomic Nerve Dysfunction of Parkinson's Disease: an Animal Model Study.Molecular neurobiology, , Volume: 60, Issue:8, 2023
The Parkinson's disease-associated protein α-synuclein inhibits hepatoma by exosome delivery.Molecular carcinogenesis, , Volume: 62, Issue:8, 2023
Autophagy‑regulating miRNAs: Novel therapeutic targets for Parkinson's disease (Review).International journal of molecular medicine, , Volume: 51, Issue:6, 2023
The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson's disease.Acta neuropathologica communications, , 05-03, Volume: 11, Issue:1, 2023
Fluid and Biopsy Based Biomarkers in Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 20, Issue:4, 2023
Mechanistic Insights into Polyphenols' Aggregation Inhibition of α-Synuclein and Related Peptides.ACS chemical neuroscience, , 05-17, Volume: 14, Issue:10, 2023
Experimental models of gut-first Parkinson's disease: A systematic review.Neurogastroenterology and motility, , Volume: 35, Issue:8, 2023
LPS-induced mitochondrial dysfunction regulates innate immunity activation and α-synuclein oligomerization in Parkinson's disease.Redox biology, , Volume: 63, 2023
Gut-to-Brain α-Synuclein Transmission in Parkinson's Disease: Evidence for Prion-like Mechanisms.International journal of molecular sciences, , Apr-13, Volume: 24, Issue:8, 2023
Pathophysiology and Neuroimmune Interactions Underlying Parkinson's Disease and Traumatic Brain Injury.International journal of molecular sciences, , Apr-13, Volume: 24, Issue:8, 2023
Revisiting Alpha-Synuclein Pathways to Inflammation.International journal of molecular sciences, , Apr-12, Volume: 24, Issue:8, 2023
Roflumilast escalates α-synuclein aggregate degradation in rotenone-induced Parkinson's disease in rats: Modulation of the ubiquitin-proteasome system and endoplasmic reticulum stress.Chemico-biological interactions, , Jul-01, Volume: 379, 2023
A seed amplification assay to detect Parkinson disease pathology.Nature reviews. Neurology, , Volume: 19, Issue:6, 2023
Naringenin-Functionalized Gold Nanoparticles and Their Role in α-Synuclein Stabilization.Langmuir : the ACS journal of surfaces and colloids, , 05-30, Volume: 39, Issue:21, 2023
Cntnap4 partial deficiency exacerbates α-synuclein pathology through astrocyte-microglia C3-C3aR pathway.Cell death & disease, , 04-22, Volume: 14, Issue:4, 2023
Targeting the GBA1 pathway to slow Parkinson disease: Insights into clinical aspects, pathogenic mechanisms and new therapeutic avenues.Pharmacology & therapeutics, , Volume: 246, 2023
Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson's disease.Nature communications, , 04-19, Volume: 14, Issue:1, 2023
Fluorescence labeling methods influence the aggregation process of α-syn Nanoscale, , May-11, Volume: 15, Issue:18, 2023
Immunological Features of LRRK2 Function and Its Role in the Gut-Brain Axis Governing Parkinson's Disease.Journal of Parkinson's disease, , Volume: 13, Issue:3, 2023
Proposal for a Biologic Staging System of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 13, Issue:3, 2023
CaMovement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:6, 2023
MALAT1 Mediates Mediators of inflammation, , Volume: 2023, 2023
Lewy bodies, iron, inflammation and neuromelanin: pathological aspects underlying Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 130, Issue:5, 2023
The brain-first vs. body-first model of Parkinson's disease with comparison to alternative models.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 130, Issue:6, 2023
Targeting α-Synuclein: A Further Viewpoint.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:4, 2023
Kinetic control in amyloid polymorphism: Different agitation and solution conditions promote distinct amyloid polymorphs of alpha-synuclein.Biochimica et biophysica acta. Proteins and proteomics, , Jul-01, Volume: 1871, Issue:4, 2023
Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional study.The Lancet. Neurology, , Volume: 22, Issue:5, 2023
α-synuclein seed amplification and its uses in Parkinson's disease.The Lancet. Neurology, , Volume: 22, Issue:5, 2023
Novel FABP3 ligand, HY-11-9, ameliorates neuropathological deficits in MPTP-induced Parkinsonism in mice.Journal of pharmacological sciences, , Volume: 152, Issue:1, 2023
Discerning Modulation of α-Synuclein Amyloid Assembly by α-Crystallin.ACS chemical neuroscience, , 05-03, Volume: 14, Issue:9, 2023
⍺-Synuclein Structural Diversity and the Cellular Environment in ⍺-Synuclein Transmission Models and Humans.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 20, Issue:1, 2023
Double-Edged Effects of Venglustat on Behavior and Pathology in Mice Overexpressing α-Synuclein.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:6, 2023
α-Synuclein Preformed Fibrils Bind to β-Neurexins and Impair β-Neurexin-Mediated Presynaptic Organization.Cells, , 04-04, Volume: 12, Issue:7, 2023
Unraveling the Complex Interplay between Alpha-Synuclein and Epigenetic Modification.International journal of molecular sciences, , Apr-02, Volume: 24, Issue:7, 2023
Effect of Electric Field on α-Synuclein Fibrils: Revealed by Molecular Dynamics Simulations.International journal of molecular sciences, , Mar-28, Volume: 24, Issue:7, 2023
Targeting neuronal lysosomal dysfunction caused by β-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct.Nature communications, , 04-12, Volume: 14, Issue:1, 2023
The cervical lymph node contributes to peripheral inflammation related to Parkinson's disease.Journal of neuroinflammation, , Apr-10, Volume: 20, Issue:1, 2023
Cognitive heterogeneity in Parkinson's disease: A mechanistic view.Neuron, , 05-17, Volume: 111, Issue:10, 2023
Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism.Nature communications, , 04-06, Volume: 14, Issue:1, 2023
Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage.Nature communications, , 04-06, Volume: 14, Issue:1, 2023
African walnut (Tetracarpidium conophorum) extract upregulates glucocerebrosidase activity and circumvents Parkinsonian changes in the Hippocampus via the activation of heatshock proteins.Journal of chemical neuroanatomy, , Volume: 130, 2023
Interfacial properties of α-synuclein's Parkinsonian variants.Biophysical chemistry, , Volume: 297, 2023
Alpha-synuclein in Parkinson's disease: a villain or tragic hero? A critical view of the formation of α-synuclein aggregates induced by dopamine metabolites and viral infection.Expert review of neurotherapeutics, , Volume: 23, Issue:4, 2023
The interplay between monocytes, α-synuclein and LRRK2 in Parkinson's disease.Biochemical Society transactions, , 04-26, Volume: 51, Issue:2, 2023
Cerebrospinal fluid lipoproteins inhibit α-synuclein aggregation by interacting with oligomeric species in seed amplification assays.Molecular neurodegeneration, , 04-01, Volume: 18, Issue:1, 2023
Non-invasive auditory and visual stimulation attenuates α-Synuclein deposition and improves motor and non-motor symptoms in PD mice.Experimental neurology, , Volume: 364, 2023
Modulation of cytotoxic amyloid fibrillation and mitochondrial damage of α-synuclein by catechols mediated conformational changes.Scientific reports, , 03-31, Volume: 13, Issue:1, 2023
Cerebrospinal fluid alpha-synuclein, amyloid beta, total tau, and phosphorylated tau in tremor-dominant Parkinson's disease.Acta neurologica Belgica, , Volume: 123, Issue:4, 2023
Identification of a Putative α-synuclein Radioligand Using an in silico Similarity Search.Molecular imaging and biology, , Volume: 25, Issue:4, 2023
Alpha Synuclein: Neurodegeneration and Inflammation.International journal of molecular sciences, , Mar-21, Volume: 24, Issue:6, 2023
Gene Expression Profiling as a Novel Diagnostic Tool for Neurodegenerative Disorders.International journal of molecular sciences, , Mar-17, Volume: 24, Issue:6, 2023
Dopamine Transmission Imbalance in Neuroinflammation: Perspectives on Long-Term COVID-19.International journal of molecular sciences, , Mar-15, Volume: 24, Issue:6, 2023
Determining the Location of the α-Synuclein Dimer Interface Using Native Top-Down Fragmentation and Isotope Depletion-Mass Spectrometry.Journal of the American Society for Mass Spectrometry, , May-03, Volume: 34, Issue:5, 2023
Central and peripheral α-synuclein in Parkinson disease detected by seed amplification assay.Annals of clinical and translational neurology, , Volume: 10, Issue:5, 2023
Sex hormones differentially contribute to Parkinson disease in males: A multimodal biomarker study.European journal of neurology, , Volume: 30, Issue:7, 2023
Small molecule-based fluorescent probes for the detection of α-Synuclein aggregation states.Bioorganic & medicinal chemistry letters, , 04-15, Volume: 86, 2023
Biochemical study of the effect of mesenchymal stem cells-derived exosome versus L-Dopa in experimentally induced Parkinson's disease in rats.Molecular and cellular biochemistry, , Volume: 478, Issue:12, 2023
Vinpocetine prevents rotenone-induced Parkinson disease motor and non-motor symptoms through attenuation of oxidative stress, neuroinflammation and α-synuclein expressions in rats.Neurotoxicology, , Volume: 96, 2023
Cannabidiol Recovers Dopaminergic Neuronal Damage Induced by Reserpine or α-synuclein in Caenorhabditis elegans.Neurochemical research, , Volume: 48, Issue:8, 2023
Activation of ROS-PERK-TFEB by filbertone ameliorates neurodegenerative diseases via enhancing the autophagy-lysosomal pathway.The Journal of nutritional biochemistry, , Volume: 118, 2023
Unexpected phenotypic and molecular changes of combined glucocerebrosidase and acid sphingomyelinase deficiency.Disease models & mechanisms, , 06-01, Volume: 16, Issue:6, 2023
Inflammasome inhibition protects dopaminergic neurons from α-synuclein pathology in a model of progressive Parkinson's disease.Journal of neuroinflammation, , Mar-21, Volume: 20, Issue:1, 2023
Inhibitory mechanism of n-MTAB AuNPs for α-synuclein aggregation.Journal of molecular modeling, , Mar-21, Volume: 29, Issue:4, 2023
Host-to-graft Propagation of α-synuclein in a Mouse Model of Parkinson's Disease: Intranigral Versus Intrastriatal Transplantation.Transplantation, , 08-01, Volume: 107, Issue:8, 2023
Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson's disease-related fibril polymorphism.Acta neuropathologica, , Volume: 145, Issue:5, 2023
Exploration and Exploitation Approaches Based on Generative Machine Learning to Identify Potent Small Molecule Inhibitors of α-Synuclein Secondary Nucleation.Journal of chemical theory and computation, , Jul-25, Volume: 19, Issue:14, 2023
Functional and neuropathological changes induced by injection of distinct alpha-synuclein strains: A pilot study in non-human primates.Neurobiology of disease, , Volume: 180, 2023
Misfolded α-Synuclein Assessment in the Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorder.Neurology, , 05-02, Volume: 100, Issue:18, 2023
Suppression of neuroinflammation and α-synuclein oligomerization by rotarod walking exercise in subacute MPTP model of Parkinson's disease.Neurochemistry international, , Volume: 165, 2023
Genetic testing for Parkinson's disease in clinical practice.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 130, Issue:6, 2023
Rose essential oil diminishes dopaminergic neuron degenerations and reduces α-synuclein aggregation in Caenorhabditis elegans models of Parkinson's disease.Phytotherapy research : PTR, , Volume: 37, Issue:7, 2023
α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies.Translational neurodegeneration, , 03-14, Volume: 12, Issue:1, 2023
Acupuncture inhibits autophagy and repairs synapses by activating the mTOR pathway in Parkinson's disease depression model rats.Brain research, , 06-01, Volume: 1808, 2023
The Role of Alpha-Synuclein Deposits in Parkinson's Disease: A Focus on the Human Retina.International journal of molecular sciences, , Feb-23, Volume: 24, Issue:5, 2023
Recent Advances in the Treatment of Genetic Forms of Parkinson's Disease: Hype or Hope?Cells, , 02-27, Volume: 12, Issue:5, 2023
Mesenchymal stem-cell-derived microvesicles ameliorate MPTP-induced neurotoxicity in mice: a role of the gut-microbiota-brain axis.Psychopharmacology, , Volume: 240, Issue:5, 2023
Meclofenoxate Inhibits Aggregation of Alpha-synuclein Protein and peptide letters, , Volume: 30, Issue:5, 2023
Unravelling the destabilization potential of ellagic acid on α-synuclein fibrils using molecular dynamics simulations.Physical chemistry chemical physics : PCCP, , Mar-15, Volume: 25, Issue:11, 2023
Cryo-EM structure of amyloid fibril formed by α-synuclein hereditary A53E mutation reveals a distinct protofilament interface.The Journal of biological chemistry, , Volume: 299, Issue:4, 2023
Pathological Pathways and Alpha-Synuclein in Parkinson's Disease: A View from the Periphery.Frontiers in bioscience (Landmark edition), , 02-23, Volume: 28, Issue:2, 2023
Opposing effects of β-2 and β-1 adrenergic receptor signaling on neuroinflammation and dopaminergic neuron survival in α-synuclein-mediated neurotoxicity.Journal of neuroinflammation, , Mar-02, Volume: 20, Issue:1, 2023
Ginkgolide A improves the pleiotropic function and reinforces the neuroprotective effects by mesenchymal stem cell-derived exosomes in 6-OHDA-induced cell model of Parkinson's disease.Aging, , 02-20, Volume: 15, Issue:5, 2023
Serotonin in synucleinopathies.Behavioural brain research, , 05-08, Volume: 445, 2023
Alpha-synuclein in Parkinson's disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction.Cell death & disease, , 03-01, Volume: 14, Issue:3, 2023
CRISPR-Cas9-Edited SNCA Knockout Human Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons and Their Vulnerability to Neurotoxicity.Biological & pharmaceutical bulletin, , Volume: 46, Issue:3, 2023
Restoration of Adult Neurogenesis by Intranasal Administration of Gangliosides GD3 and GM1 in The Olfactory Bulb of A53T Alpha-Synuclein-Expressing Parkinson's-Disease Model Mice.Molecular neurobiology, , Volume: 60, Issue:6, 2023
Duodenal alpha-Synuclein Pathology and Enteric Gliosis in Advanced Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:5, 2023
Specific Detection of Physiological S129 Phosphorylated α-Synuclein in Tissue Using Proximity Ligation Assay.Journal of Parkinson's disease, , Volume: 13, Issue:2, 2023
Circular RNAs in Parkinson's Disease: Reliable Biological Markers and Targets for Rehabilitation.Molecular neurobiology, , Volume: 60, Issue:6, 2023
Nicotine-Mediated Recruitment of GABAergic Neurons to a Dopaminergic Phenotype Attenuates Motor Deficits in an Alpha-Synuclein Parkinson's Model.International journal of molecular sciences, , Feb-20, Volume: 24, Issue:4, 2023
Role of Deubiquitinases in Parkinson's Disease-Therapeutic Perspectives.Cells, , 02-17, Volume: 12, Issue:4, 2023
Interneuronal In Vivo Transfer of Synaptic Proteins.Cells, , 02-10, Volume: 12, Issue:4, 2023
Mechanisms of Glucocerebrosidase Dysfunction in Parkinson's Disease.Journal of molecular biology, , 06-15, Volume: 435, Issue:12, 2023
Isocyanate induces cytotoxicity via activation of phosphorylated alpha synuclein protein, nitrosative stress, and apoptotic pathway in Parkinson's Disease model-SHSY-5Y cells.Neurological research, , Volume: 45, Issue:7, 2023
Nanoscale imaging of individual amyloid aggregates extracted from brains of Alzheimer and Parkinson patients reveals presence of lipids in α-synuclein but not in amyloid βProtein science : a publication of the Protein Society, , Volume: 32, Issue:4, 2023
DJ-1 Molecular Chaperone Activity Depresses Tau Aggregation Propensity through Interaction with Monomers.Biochemistry, , 03-07, Volume: 62, Issue:5, 2023
Influence of Cholesterol on the Membrane Binding and Conformation of α-Synuclein.The journal of physical chemistry. B, , 03-09, Volume: 127, Issue:9, 2023
Structural and dynamic insights into α-synuclein dimer conformations.Structure (London, England : 1993), , 04-06, Volume: 31, Issue:4, 2023
Integrin Mac1 mediates paraquat and maneb-induced learning and memory impairments in mice through NADPH oxidase-NLRP3 inflammasome axis-dependent microglial activation.Journal of neuroinflammation, , Feb-18, Volume: 20, Issue:1, 2023
Role of rodent models in advancing precision medicine for Parkinson's disease.Handbook of clinical neurology, , Volume: 193, 2023
Spontaneous nucleation and fast aggregate-dependent proliferation of α-synuclein aggregates within liquid condensates at neutral pH.Proceedings of the National Academy of Sciences of the United States of America, , 02-28, Volume: 120, Issue:9, 2023
Selecting the Best Animal Model of Parkinson's Disease for Your Research Purpose: Insight from Current neuropharmacology, , Volume: 21, Issue:5, 2023
Mixed pathology as a rule, not exception: Time to reconsider disease nosology.Handbook of clinical neurology, , Volume: 192, 2023
Models of precision medicine for neurodegeneration.Handbook of clinical neurology, , Volume: 192, 2023
The alteration of intestinal mucosal α-synuclein expression and mucosal microbiota in Parkinson's disease.Applied microbiology and biotechnology, , Volume: 107, Issue:5-6, 2023
Quantitative Seed Amplification Assay: A Proof-of-Principle Study.The journal of physical chemistry. B, , 03-02, Volume: 127, Issue:8, 2023
Protective mechanisms by glial cell line-derived neurotrophic factor and cerebral dopamine neurotrophic factor against the α-synuclein accumulation in Parkinson's disease.Biochemical Society transactions, , 02-27, Volume: 51, Issue:1, 2023
α-Synuclein Conformational Strains as Drivers of Phenotypic Heterogeneity in Neurodegenerative Diseases.Journal of molecular biology, , 06-15, Volume: 435, Issue:12, 2023
TNFRSF10B is involved in motor dysfunction in Parkinson's disease by regulating exosomal α-synuclein secretion from microglia.Journal of chemical neuroanatomy, , Volume: 129, 2023
A functional role for alpha-synuclein in neuroimmune responses.Journal of neuroimmunology, , 03-15, Volume: 376, 2023
The link between neuroinflammation and the neurovascular unit in synucleinopathies.Science advances, , 02-15, Volume: 9, Issue:7, 2023
α-Synuclein induces prodromal symptoms of Parkinson's disease via activating TLR2/MyD88/NF-κB pathway in Schwann cells of vagus nerve in a rat model.Journal of neuroinflammation, , Feb-14, Volume: 20, Issue:1, 2023
Impaired Autophagic-Lysosomal Fusion in Parkinson's Patient Midbrain Neurons Occurs through Loss of ykt6 and Is Rescued by Farnesyltransferase Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 04-05, Volume: 43, Issue:14, 2023
α-Synuclein Aggregation Inhibitory Procerolides and Diphenylalkanes from the Ascidian Journal of natural products, , 03-24, Volume: 86, Issue:3, 2023
Palmitoylation of the Parkinson's disease-associated protein synaptotagmin-11 links its turnover to α-synuclein homeostasis.Science signaling, , 02-14, Volume: 16, Issue:772, 2023
α-Synuclein decoy peptide protects mice against α-synuclein-induced memory loss.CNS neuroscience & therapeutics, , Volume: 29, Issue:6, 2023
Accurate Detection of α-Synuclein Seeds in Cerebrospinal Fluid from Isolated Rapid Eye Movement Sleep Behavior Disorder and Patients with Parkinson's Disease in the DeNovo Parkinson (DeNoPa) Cohort.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:4, 2023
Combined chronic copper exposure and aging lead to neurotoxicity in vivo.Neurotoxicology, , Volume: 95, 2023
Oleuropein confers neuroprotection against rotenone-induced model of Parkinson's disease via BDNF/CREB/Akt pathway.Scientific reports, , 02-11, Volume: 13, Issue:1, 2023
The Parkinson-Associated Toxin Paraquat Shifts Physiological α-Synuclein Tetramers toward Monomers That Can Be Calpain-Truncated and Form Oligomers.The American journal of pathology, , Volume: 193, Issue:5, 2023
DNA Methylation of α-Synuclein Intron 1 Is Significantly Decreased in the Frontal Cortex of Parkinson's Individuals with International journal of molecular sciences, , Jan-31, Volume: 24, Issue:3, 2023
Nuclear α-Synuclein-Derived Cytotoxic Effect via Altered Ribosomal RNA Processing in Primary Mouse Embryonic Fibroblasts.International journal of molecular sciences, , Jan-21, Volume: 24, Issue:3, 2023
Increased Levels of the Parkinson's Disease-Associated Gene ITPKB Correlate with Higher Expression Levels of α-Synuclein, Independent of Mutation Status.International journal of molecular sciences, , Jan-19, Volume: 24, Issue:3, 2023
Dysregulation of astrocytic CaActa neuropathologica, , Volume: 145, Issue:5, 2023
Single-Molecule Two-Color Coincidence Detection of Unlabeled alpha-Synuclein Aggregates.Angewandte Chemie (International ed. in English), , 04-03, Volume: 62, Issue:15, 2023
Translational molecular imaging and drug development in Parkinson's disease.Molecular neurodegeneration, , 02-10, Volume: 18, Issue:1, 2023
Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils.Proceedings of the National Academy of Sciences of the United States of America, , 02-14, Volume: 120, Issue:7, 2023
NLRP3 Inflammasome-Mediated Neuroinflammation and Related Mitochondrial Impairment in Parkinson's Disease.Neuroscience bulletin, , Volume: 39, Issue:5, 2023
Calcium/calmodulin-dependent serine protein kinase exacerbates mitochondrial calcium uniporter-related mitochondrial calcium overload by phosphorylating α-synuclein in Parkinson's disease.The international journal of biochemistry & cell biology, , Volume: 157, 2023
Acid ceramidase involved in pathogenic cascade leading to accumulation of α-synuclein in iPSC model of GBA1-associated Parkinson's disease.Human molecular genetics, , 05-18, Volume: 32, Issue:11, 2023
The couple of netrin-1/α-Synuclein regulates the survival of dopaminergic neurons via α-Synuclein disaggregation.BMB reports, , Volume: 56, Issue:2, 2023
Dermal Real-Time Quaking-Induced Conversion Is a Sensitive Marker to Confirm Isolated Rapid Eye Movement Sleep Behavior Disorder as an Early α-Synucleinopathy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:6, 2023
Skin α-synuclein differentiates synucleinopathies.Nature reviews. Neurology, , Volume: 19, Issue:3, 2023
[no title available]ACS chemical neuroscience, , 03-01, Volume: 14, Issue:5, 2023
Amyloid Fibers of α-Synuclein Catalyze Chemical Reactions.ACS chemical neuroscience, , 02-15, Volume: 14, Issue:4, 2023
High-affinity binding of celastrol to monomeric α-synuclein mitigates in vitro aggregation.Journal of biomolecular structure & dynamics, , Volume: 41, Issue:22, 2023
miR-101a-3p Impairs Synaptic Plasticity and Contributes to Synucleinopathy.Journal of Parkinson's disease, , Volume: 13, Issue:2, 2023
ASC specks exacerbate α‑synuclein pathology via amplifying NLRP3 inflammasome activities.Journal of neuroinflammation, , Feb-05, Volume: 20, Issue:1, 2023
The Ubiquitin Proteasome System as a Therapeutic Area in Parkinson's Disease.Neuromolecular medicine, , Volume: 25, Issue:3, 2023
Linking Genetic Risks to Pathological α-Synuclein Transmission in Parkinson's Disease.Neuroscience bulletin, , Volume: 39, Issue:7, 2023
Common Mechanisms Underlying α-Synuclein-Induced Mitochondrial Dysfunction in Parkinson's Disease.Journal of molecular biology, , 06-15, Volume: 435, Issue:12, 2023
a-Synuclein and lipids in erythrocytes of Gaucher disease carriers and patients before and after enzyme replacement therapy.PloS one, , Volume: 18, Issue:2, 2023
Comprehensive Review on Potential Signaling Pathways Involving the Transfer of α-Synuclein from the Gut to the Brain That Leads to Parkinson's Disease.ACS chemical neuroscience, , 02-15, Volume: 14, Issue:4, 2023
SH-SY5Y Cell Line Journal of integrative neuroscience, , Jan-16, Volume: 22, Issue:1, 2023
Neuron-Derived Misfolded α-Synuclein in Blood: A Potential Biomarker for Parkinson's Disease?Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:3, 2023
SARS-COV-2 infection and Parkinson's disease: Possible links and perspectives.Journal of neuroscience research, , Volume: 101, Issue:6, 2023
A Mouse Model to Test Novel Therapeutics for Parkinson's Disease: an Update on the Thy1-aSyn ("line 61") Mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 20, Issue:1, 2023
Polymorphic Alpha-Synuclein Oligomers: Characterization and Differential Detection with Novel Corresponding Antibodies.Molecular neurobiology, , Volume: 60, Issue:5, 2023
Unveiling new secrets in Parkinson's disease: The glycatome.Behavioural brain research, , 03-28, Volume: 442, 2023
Overexpression of alpha synuclein disrupts APP and Endolysosomal axonal trafficking in a mouse model of synucleinopathy.Neurobiology of disease, , Volume: 178, 2023
Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein.Nature neuroscience, , Volume: 26, Issue:2, 2023
α-Synuclein Induced the Occurrence of RBD via Interaction with OX1R and Modulated Its Degradation.Neuromolecular medicine, , Volume: 25, Issue:2, 2023
A review of the current research on in vivo and in vitro detection for alpha-synuclein: a biomarker of Parkinson's disease.Analytical and bioanalytical chemistry, , Volume: 415, Issue:9, 2023
Hybrids of polyphenolic/quinone acids, the potential preventive and therapeutic drugs for PD: Disaggregate α-Syn fibrils, inhibit inclusions, and repair damaged neurons in mice.European journal of medicinal chemistry, , Mar-05, Volume: 249, 2023
Myrcene Salvages Rotenone-Induced Loss of Dopaminergic Neurons by Inhibiting Oxidative Stress, Inflammation, Apoptosis, and Autophagy.Molecules (Basel, Switzerland), , Jan-10, Volume: 28, Issue:2, 2023
ATP13A2 Gene Silencing in Drosophila Affects Autophagic Degradation of A53T Mutant α-Synuclein.International journal of molecular sciences, , Jan-16, Volume: 24, Issue:2, 2023
α-Synuclein Aggregates in the Nigro-Striatal Dopaminergic Pathway Impair Fine Movement: Partial Reversal by the Adenosine AInternational journal of molecular sciences, , Jan-10, Volume: 24, Issue:2, 2023
Age-Related Changes of the Synucleins Profile in the Mouse Retina.Biomolecules, , 01-15, Volume: 13, Issue:1, 2023
α-Synuclein-Induced Destabilized BMAL1 mRNA Leads to Circadian Rhythm Disruption in Parkinson's Disease.Neurotoxicity research, , Volume: 41, Issue:2, 2023
On the Track of α-Synuclein in the Body: Skin Biopsies for Diagnosing Synucleinopathies?Neurology, , 04-11, Volume: 100, Issue:15, 2023
Effects of the Polyphenols Delphinidin and Rosmarinic Acid on the Inducible Intra-cellular Aggregation of Alpha-Synuclein in Model Neuron Cells.Applied biochemistry and biotechnology, , Volume: 195, Issue:7, 2023
Seed amplification assay for the detection of pathologic alpha-synuclein aggregates in cerebrospinal fluid.Nature protocols, , Volume: 18, Issue:4, 2023
The c-Abl inhibitor IkT-148009 suppresses neurodegeneration in mouse models of heritable and sporadic Parkinson's disease.Science translational medicine, , 01-18, Volume: 15, Issue:679, 2023
Who Ever Said It Would Be Easy? Reflecting on Two Clinical Trials Targeting α-Synuclein.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:3, 2023
Domain and cell type-specific immunolocalisation of voltage-gated potassium channels in the mouse striatum.Journal of chemical neuroanatomy, , Volume: 128, 2023
Neuronopathic GBA1L444P Mutation Accelerates Glucosylsphingosine Levels and Formation of Hippocampal Alpha-Synuclein Inclusions.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 01-18, Volume: 43, Issue:3, 2023
Interaction Between the Glymphatic System and α-Synuclein in Parkinson's Disease.Molecular neurobiology, , Volume: 60, Issue:4, 2023
Potential Therapeutic Effects of Policosanol from Insect Wax on Caenorhabditis elegans Models of Parkinson's Disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 18, Issue:1-2, 2023
Unravelling the genetic links between Parkinson's disease and lung cancer.Biological chemistry, , 05-25, Volume: 404, Issue:6, 2023
Lifelong constipation in Parkinson's disease and other clinically defined alpha-synucleinopathies: A population-based study in Southeast Minnesota.Parkinsonism & related disorders, , Volume: 107, 2023
Distinct effects of SDC3 and FGFRL1 on selective neurodegeneration in AD and PD.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 37, Issue:2, 2023
Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson's disease treatment.Acta pharmacologica Sinica, , Volume: 44, Issue:6, 2023
Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers.eLife, , 01-10, Volume: 12, 2023
The effects of KTKEGV repeat motif and intervening ATVA sequence on α-synuclein solubility and assembly.Journal of neurochemistry, , Volume: 165, Issue:2, 2023
EGCG attenuates α-synuclein protofibril-membrane interactions and disrupts the protofibril.International journal of biological macromolecules, , Mar-01, Volume: 230, 2023
Extracellular transportation of α-synuclein by HLA class II molecules.Biochemical and biophysical research communications, , 02-12, Volume: 644, 2023
The Consequences of GBA Deficiency in the Autophagy-Lysosome System in Parkinson's Disease Associated with GBA.Cells, , 01-03, Volume: 12, Issue:1, 2023
Ubiquilin-2 regulates pathological alpha-synuclein.Scientific reports, , 01-06, Volume: 13, Issue:1, 2023
Intrastriatal injection of Parkinson's disease intestine and vagus lysates initiates α-synucleinopathy in rat brain.Cell death & disease, , 01-05, Volume: 14, Issue:1, 2023
Role of α-synuclein in microglia: autophagy and phagocytosis balance neuroinflammation in Parkinson's disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.], , Volume: 72, Issue:3, 2023
α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 02-08, Volume: 43, Issue:6, 2023
The effect of diphenylethane side-chain substituents on dibenzocyclohexadiene formation and their inhibition of α-synuclein aggregation in vitro.Bioorganic & medicinal chemistry, , 01-15, Volume: 78, 2023
On the effect of methionine oxidation on the interplay between α-synuclein and synaptic-like vesicles.International journal of biological macromolecules, , Feb-28, Volume: 229, 2023
Cannabidivarin alleviates α-synuclein aggregation via DAF-16 in Caenorhabditis elegans.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 37, Issue:2, 2023
Relevance of Biochemical Deep Phenotyping for a Personalised Approach to Parkinson's Disease.Neuroscience, , 02-10, Volume: 511, 2023
Aggregated alpha-synuclein transcriptionally activates pro-inflammatory canonical and non-canonical NF-κB signaling pathways in peripheral monocytic cells.Molecular immunology, , Volume: 154, 2023
Evaluation of an Adoptive Cellular Therapy-Based Vaccine in a Transgenic Mouse Model of α-synucleinopathy.ACS chemical neuroscience, , 01-18, Volume: 14, Issue:2, 2023
Intranasal Rotenone Induces Alpha-Synuclein Accumulation, Neuroinflammation and Dopaminergic Neurodegeneration in Middle-Aged Mice.Neurochemical research, , Volume: 48, Issue:5, 2023
α-Synuclein in synaptic function and dysfunction.Trends in neurosciences, , Volume: 46, Issue:2, 2023
The Hidden Cell-to-Cell Trail of α-Synuclein Aggregates.Journal of molecular biology, , 06-15, Volume: 435, Issue:12, 2023
Biomimetically Engineered Amyloid-Shelled Gold Nanocomplexes for Discovering α-Synuclein Oligomer-Degrading Drugs.ACS applied materials & interfaces, , Jan-18, Volume: 15, Issue:2, 2023
Neuroprotective Role of Quercetin against Alpha-Synuclein-Associated Hallmarks in Parkinson's Disease.Current neuropharmacology, , Volume: 21, Issue:7, 2023
Helicobacter hepaticus augmentation triggers Dopaminergic degeneration and motor disorders in mice with Parkinson's disease.Molecular psychiatry, , Volume: 28, Issue:3, 2023
Neuroinflammation, immune response and α-synuclein pathology: how animal models are helping us to connect dots.Expert opinion on drug discovery, , Volume: 18, Issue:1, 2023
Anti-α-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson's disease.Neurobiology of disease, , Volume: 177, 2023
Mitochondrial signaling on innate immunity activation in Parkinson disease.Current opinion in neurobiology, , Volume: 78, 2023
Monitoring α-synuclein aggregation.Neurobiology of disease, , Volume: 176, 2023
Hypoxic stress accelerates the propagation of pathological alpha-synuclein and degeneration of dopaminergic neurons.CNS neuroscience & therapeutics, , Volume: 29, Issue:2, 2023
Conformational change of α-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease.Structure (London, England : 1993), , 01-05, Volume: 31, Issue:1, 2023
Overexpression-Induced α-Synuclein Brain Spreading.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 20, Issue:1, 2023
miRNA in Parkinson's disease: From pathogenesis to theranostic approaches.Journal of cellular physiology, , Volume: 238, Issue:2, 2023
Ganglioside GM3 stimulates lipid-protein co-assembly in α-synuclein amyloid formation.Biophysical chemistry, , Volume: 293, 2023
Proteostasis in Parkinson's disease: Recent development and possible implication in diagnosis and therapeutics.Ageing research reviews, , Volume: 84, 2023
Oligomeric α-synuclein and tau aggregates in NDEVs differentiate Parkinson's disease from atypical parkinsonisms.Neurobiology of disease, , Volume: 176, 2023
Endoplasmic Reticulum Stress-Regulated Chaperones as a Serum Biomarker Panel for Parkinson's Disease.Molecular neurobiology, , Volume: 60, Issue:3, 2023
Pathological α-synuclein accumulation, CSF metabolites changes and brain microstructures in cynomolgus monkeys treated with 6-hydroxydopamine.Neurotoxicology, , Volume: 94, 2023
Brain and Cerebrospinal Fluid α-Synuclein Real-Time Quaking-Induced Conversion Identifies Lewy Body Pathology in LRRK2-PD.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:2, 2023
Hydroxytyrosol and dopamine metabolites: Anti-aggregative effect and neuroprotective activity against α-synuclein-induced toxicity.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, , Volume: 171, 2023
Non-SUMOylated alternative spliced isoforms of alpha-synuclein are more aggregation-prone and toxic.Mechanisms of ageing and development, , Volume: 209, 2023
Repositioning doxycycline for treating synucleinopathies: Evidence from a pre-clinical mouse model.Parkinsonism & related disorders, , Volume: 106, 2023
Review on the interactions between dopamine metabolites and α-Synuclein in causing Parkinson's disease.Neurochemistry international, , Volume: 162, 2023
Role of enteric glia and microbiota-gut-brain axis in parkinson disease pathogenesis.Ageing research reviews, , Volume: 84, 2023
Are patients with Parkinson's disease at a lower risk of catching the common cold? Propensity score matching.Parkinsonism & related disorders, , Volume: 106, 2023
HtrA2 regulates α-Synuclein-mediated mitochondrial reactive oxygen species production in the mitochondria of microglia.Biochemical and biophysical research communications, , 01-01, Volume: 638, 2023
N-homocysteinylation of α-synuclein promotes its aggregation and neurotoxicity.Aging cell, , Volume: 22, Issue:3, 2023
An Update on Peripheral Blood Extracellular Vesicles as Biomarkers for Parkinson's Disease Diagnosis.Neuroscience, , 02-10, Volume: 511, 2023
α-Synuclein aggregation causes muscle atrophy through neuromuscular junction degeneration.Journal of cachexia, sarcopenia and muscle, , Volume: 14, Issue:1, 2023
Nicotine-Mediated Rescue of α-Synuclein Toxicity Requires Synaptic Vesicle Glycoprotein 2 in Drosophila.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:2, 2023
Potential application of heat shock proteins as therapeutic targets in Parkinson's disease.Neurochemistry international, , Volume: 162, 2023
Neuroprotective potential of plant derived parenchymal stem cells extract on environmental and genetic models of Parkinson disease through attenuation of oxidative stress and neuroinflammation.Metabolic brain disease, , Volume: 38, Issue:2, 2023
Endothelial LRP1-ICD Accelerates Cognition-Associated Alpha-Synuclein Pathology and Neurodegeneration through PARP1 Activation in a Mouse Model of Parkinson's Disease.Molecular neurobiology, , Volume: 60, Issue:2, 2023
A Combined Panel of Salivary Biomarkers in de novo Parkinson's Disease.Annals of neurology, , Volume: 93, Issue:3, 2023
Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates.Molecular pharmaceutics, , 01-02, Volume: 20, Issue:1, 2023
Targeting α-synuclein post-translational modifications in Parkinson's disease.Behavioural brain research, , 02-15, Volume: 439, 2023
GALC variants affect galactosylceramidase enzymatic activity and risk of Parkinson's disease.Brain : a journal of neurology, , 05-02, Volume: 146, Issue:5, 2023
Association Between Decreased Srpk3 Expression and Increased Substantia Nigra Alpha-Synuclein Level in an MPTP-Induced Parkinson's Disease Mouse Model.Molecular neurobiology, , Volume: 60, Issue:2, 2023
Differential interactions of α-synuclein conformers affect refolding and activity of proteins.Journal of biochemistry, , Feb-03, Volume: 173, Issue:2, 2023
Microglia and astrocyte activation is region-dependent in the α-synuclein mouse model of Parkinson's disease.Glia, , Volume: 71, Issue:3, 2023
α-Synuclein as a Target for Metallo-Anti-Neurodegenerative Agents.Angewandte Chemie (International ed. in English), , 01-02, Volume: 62, Issue:1, 2023
α-Synuclein induces Th17 differentiation and impairs the function and stability of Tregs by promoting RORC transcription in Parkinson's disease.Brain, behavior, and immunity, , Volume: 108, 2023
Novel naturally occurring autoantibodies attenuate α-synuclein pathology in a mouse model of Parkinson's disease.Neuropathology and applied neurobiology, , Volume: 49, Issue:1, 2023
CHCHD2 p.Thr61Ile knock-in mice exhibit motor defects and neuropathological features of Parkinson's disease.Brain pathology (Zurich, Switzerland), , Volume: 33, Issue:3, 2023
Selective neurodegeneration generated by intravenous α-synuclein pre-formed fibril administration is not associated with endogenous α-synuclein levels in the rat brain.Brain pathology (Zurich, Switzerland), , Volume: 33, Issue:3, 2023
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein.Molecular psychiatry, , Volume: 28, Issue:7, 2023
Decreased Water Mobility Contributes To Increased α-Synuclein Aggregation.Angewandte Chemie (International ed. in English), , 02-06, Volume: 62, Issue:7, 2023
Propagation of Distinct α-Synuclein Strains Within Human Reconstructed Neuronal Network and Associated Neuronal Dysfunctions.Methods in molecular biology (Clifton, N.J.), , Volume: 2551, 2023
α-Synuclein Fibril, Ribbon and Fibril-91 Amyloid Polymorphs Generation for Structural Studies.Methods in molecular biology (Clifton, N.J.), , Volume: 2551, 2023
PET imaging in animal models of Parkinson's disease.Behavioural brain research, , 02-13, Volume: 438, 2023
Salivary α-Synuclein RT-QuIC Correlates with Disease Severity in de novo Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:1, 2023
Low Glucocerebrosidase Activity Predicts Dementia in Parkinson Disease: Less Is Not More!Neurology, , Jan-24, Volume: 100, Issue:4, 2023
Association of Glial Activation and α-Synuclein Pathology in Parkinson's Disease.Neuroscience bulletin, , Volume: 39, Issue:3, 2023
Engineered graphene quantum dot nanocomposite triggers α-synuclein defibrillation: Therapeutics against Parkinson's disease.Nanomedicine : nanotechnology, biology, and medicine, , Volume: 47, 2023
Longitudinal striatal dopamine transporter binding and cerebrospinal fluid alpha-synuclein, amyloid beta, total tau, and phosphorylated tau in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 44, Issue:2, 2023
Olfactory Neuron Prokineticin-2 as a Potential Target in Parkinson's Disease.Annals of neurology, , Volume: 93, Issue:1, 2023
Phytoconstituents of Datura metel extract improved motor coordination in haloperidol-induced cataleptic mice: Dual-target molecular docking and behavioural studies.Journal of ethnopharmacology, , Jan-10, Volume: 300, 2023
The GBA variant E326K is associated with alpha-synuclein aggregation and lipid droplet accumulation in human cell lines.Human molecular genetics, , 02-19, Volume: 32, Issue:5, 2023
Effects of N-terminal Acetylation on the Aggregation of Disease-related α-synuclein Variants.Journal of molecular biology, , 01-15, Volume: 435, Issue:1, 2023
Pathological and Therapeutic Advances in Parkinson's Disease: Mitochondria in the Interplay.Journal of Alzheimer's disease : JAD, , Volume: 94, Issue:s1, 2023
Lysosomal Pathogenesis of Parkinson's Disease: Insights From LRRK2 and GBA1 Rodent Models.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 20, Issue:1, 2023
Nanostructured label-free electrochemical immunosensor for detection of a Parkinson's disease biomarker.Talanta, , Jan-15, Volume: 252, 2023
Failure of diet-induced transcriptional adaptations in alpha-synuclein transgenic mice.Human molecular genetics, , 01-13, Volume: 32, Issue:3, 2023
Spreading of alpha-synuclein between different cell types.Behavioural brain research, , 01-05, Volume: 436, 2023
Parkinson's Disease: A Multisystem Disorder.Neuroscience bulletin, , Volume: 39, Issue:1, 2023
Synthesis of a natural quinoline alkaloid isolated from the deep-sea-derived fungus and its potential as a therapeutic for Parkinson's disease.Journal of Asian natural products research, , Volume: 25, Issue:5, 2023
CSF-derived extracellular vesicles from patients with Parkinson's disease induce symptoms and pathology.Brain : a journal of neurology, , 01-05, Volume: 146, Issue:1, 2023
The Parkinson's disease variant rs356182 regulates neuronal differentiation independently from alpha-synuclein.Human molecular genetics, , 01-01, Volume: 32, Issue:1, 2023
Extracellular vesicle biomarkers for cognitive impairment in Parkinson's disease.Brain : a journal of neurology, , 01-05, Volume: 146, Issue:1, 2023
Parkinson's disease risk protein TMEM175 keeps lysosomes running on a proton leak.Nature structural & molecular biology, , Volume: 29, Issue:7, 2022
Implications of intracellular protein degradation pathways in Parkinson's disease and therapeutics.Journal of neuroscience research, , Volume: 100, Issue:10, 2022
The emerging role of LRRK2 in tauopathies.Clinical science (London, England : 1979), , 07-15, Volume: 136, Issue:13, 2022
Molecular and functional interactions of alpha-synuclein with Rab3a.The Journal of biological chemistry, , Volume: 298, Issue:9, 2022
Role of platelet in Parkinson's disease: Insights into pathophysiology & theranostic solutions.Ageing research reviews, , Volume: 80, 2022
Could Blood Hexosylsphingosine Be a Marker for Parkinson's Disease Linked with GBA1 Mutations?Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:8, 2022
Therapeutic Insights on Ferroptosis in Parkinson's disease.European journal of pharmacology, , Sep-05, Volume: 930, 2022
Structural and mechanistic insights into amyloid-β and α-synuclein fibril formation and polyphenol inhibitor efficacy in phospholipid bilayers.The FEBS journal, , Volume: 289, Issue:1, 2022
A sudden collapse: the disaggregation of amyloid fibres.The EMBO journal, , 08-16, Volume: 41, Issue:16, 2022
Heparan sulfate proteoglycans mediate prion-like α-synuclein toxicity in Parkinson's in vivo models.Life science alliance, , Volume: 5, Issue:11, 2022
[Advances in Parkinson's disease induced by α-synuclein transmitted through the gut-brain axis].Sheng wu gong cheng xue bao = Chinese journal of biotechnology, , Jun-25, Volume: 38, Issue:6, 2022
[In vivo imaging of α-synuclein].Nihon yakurigaku zasshi. Folia pharmacologica Japonica, , Volume: 157, Issue:4, 2022
The role of LRRK2 in the periphery: link with Parkinson's disease and inflammatory diseases.Neurobiology of disease, , 10-01, Volume: 172, 2022
Lippia grata essential oil complexed with β-cyclodextrin ameliorates biochemical and behavioral deficits in an animal model of progressive parkinsonism.Metabolic brain disease, , Volume: 37, Issue:7, 2022
Synaptic location is a determinant of the detrimental effects of α-synuclein pathology to glutamatergic transmission in the basolateral amygdala.eLife, , 07-01, Volume: 11, 2022
p21-activated kinase 4 controls the aggregation of α-synuclein by reducing the monomeric and aggregated forms of α-synuclein: involvement of the E3 ubiquitin ligase NEDD4-1.Cell death & disease, , 06-30, Volume: 13, Issue:6, 2022
Quantum-dot-labeled synuclein seed assay identifies drugs modulating the experimental prion-like transmission.Communications biology, , 06-29, Volume: 5, Issue:1, 2022
Leveraging the preformed fibril model to distinguish between alpha-synuclein inclusion- and nigrostriatal degeneration-associated immunogenicity.Neurobiology of disease, , Volume: 171, 2022
Lysosomal functions and dysfunctions: Molecular and cellular mechanisms underlying Gaucher disease and its association with Parkinson disease.Advanced drug delivery reviews, , Volume: 187, 2022
3,4-Dihydroxyphenylethanol and 3,4-dihydroxyphenylacetic acid affect the aggregation process of E46K variant of α-synuclein at different extent: Insights into the interplay between protein dynamics and catechol effect.Protein science : a publication of the Protein Society, , Volume: 31, Issue:7, 2022
Crossroads between copper ions and amyloid formation in Parkinson's disease.Essays in biochemistry, , 12-16, Volume: 66, Issue:7, 2022
Central and Peripheral Inflammation: Connecting the Immune Responses of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
Microglia in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
Artemisia Leaf Extract protects against neuron toxicity by TRPML1 activation and promoting autophagy/mitophagy clearance in both in vitro and in vivo models of MPP+/MPTP-induced Parkinson's disease.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 104, 2022
Phosphorylated alpha-synuclein in Iba1-positive macrophages in the skin of patients with Parkinson's disease.Annals of clinical and translational neurology, , Volume: 9, Issue:8, 2022
Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization.Journal of the American Chemical Society, , 07-13, Volume: 144, Issue:27, 2022
LRRK2 and Proteostasis in Parkinson's Disease.International journal of molecular sciences, , Jun-18, Volume: 23, Issue:12, 2022
Interactions between S100A9 and Alpha-Synuclein: Insight from NMR Spectroscopy.International journal of molecular sciences, , Jun-17, Volume: 23, Issue:12, 2022
Alpha-Synuclein Autoimmune Decline in Prodromal Multiple System Atrophy and Parkinson's Disease.International journal of molecular sciences, , Jun-12, Volume: 23, Issue:12, 2022
Early Forms of Biomolecules, , 05-25, Volume: 12, Issue:6, 2022
Temporal, spatial and molecular pattern of dopaminergic neurodegeneration in the AAV-A53T α-synuclein rat model of Parkinson's disease.Behavioural brain research, , 08-26, Volume: 432, 2022
Role of post-translational modifications on the alpha-synuclein aggregation-related pathogenesis of Parkinson's disease.BMB reports, , Volume: 55, Issue:7, 2022
Piperine promotes autophagy flux by P2RX4 activation in Autophagy, , Volume: 18, Issue:3, 2022
The Effects of Novel Formulations of Edaravone and Curcumin in the Mouse Intrastriatal Lipopolysaccharide Model of Parkinson's Disease.Frontiers in bioscience (Scholar edition), , 05-07, Volume: 14, Issue:2, 2022
Methylation of alpha-synuclein in a Sudanese cohort.Parkinsonism & related disorders, , Volume: 101, 2022
Investigating key factors underlying neurodegeneration linked to alpha-synuclein spread.Neuropathology and applied neurobiology, , Volume: 48, Issue:6, 2022
Neuroinflammation and Immune Changes in Prodromal Parkinson's Disease and Other Synucleinopathies.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
Detection of neuron-derived pathological α-synuclein in blood.Brain : a journal of neurology, , 09-14, Volume: 145, Issue:9, 2022
Restricting α-synuclein transport into mitochondria by inhibition of α-synuclein-VDAC complexation as a potential therapeutic target for Parkinson's disease treatment.Cellular and molecular life sciences : CMLS, , Jun-19, Volume: 79, Issue:7, 2022
Plasma and serum alpha-synuclein as a biomarker in Parkinson's disease: A meta-analysis.Parkinsonism & related disorders, , Volume: 99, 2022
Glutamatergic transmission and receptor expression in the synucleinopathy h-α-synL62 mouse model: Effects of hydromethylthionine.Cellular signalling, , Volume: 97, 2022
Exogenous human α-Synuclein acts in vitro as a mild platelet antiaggregant inhibiting α-thrombin-induced platelet activation.Scientific reports, , 06-14, Volume: 12, Issue:1, 2022
Role of Ubiquitin-Proteasome and Autophagy-Lysosome Pathways in α-Synuclein Aggregate Clearance.Molecular neurobiology, , Volume: 59, Issue:9, 2022
Loss of Drosophila NUS1 results in cholesterol accumulation and Parkinson's disease-related neurodegeneration.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 36, Issue:7, 2022
Automated quantification of neuronal swellings in a preclinical rodent model of Parkinson's disease detects region-specific changes in pathology.Journal of neuroscience methods, , 08-01, Volume: 378, 2022
The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability.Cell, , 06-09, Volume: 185, Issue:12, 2022
Alpha-synuclein and tau are abundantly expressed in the ENS of the human appendix and monkey cecum.PloS one, , Volume: 17, Issue:6, 2022
Pathogenic Impact of α-Synuclein Phosphorylation and Its Kinases in α-Synucleinopathies.International journal of molecular sciences, , Jun-01, Volume: 23, Issue:11, 2022
Immunogenicity of MultiTEP-Platform-Based Recombinant Protein Vaccine, PV-1950R, Targeting Three B-Cell Antigenic Determinants of Pathological α-Synuclein.International journal of molecular sciences, , May-29, Volume: 23, Issue:11, 2022
Alpha-Synuclein Aggregation Pathway in Parkinson's Disease: Current Status and Novel Therapeutic Approaches.Cells, , 05-24, Volume: 11, Issue:11, 2022
Genotypic-Phenotypic Analysis, Metabolic Profiling and Clinical Correlations in Parkinson's Disease Patients from Tamil Nadu Population, India.Journal of molecular neuroscience : MN, , Volume: 72, Issue:8, 2022
The immunology of Parkinson's disease.Seminars in immunopathology, , Volume: 44, Issue:5, 2022
Amyloids on Membrane Interfaces: Implications for Neurodegeneration.The Journal of membrane biology, , Volume: 255, Issue:6, 2022
Charge detection mass spectrometry on human-amplified fibrils from different synucleinopathies.Chemical communications (Cambridge, England), , Jun-23, Volume: 58, Issue:51, 2022
The role of Toll-like receptors and neuroinflammation in Parkinson's disease.Journal of neuroinflammation, , Jun-06, Volume: 19, Issue:1, 2022
Induced pluripotent stem cells: a tool for modeling Parkinson's disease.Trends in neurosciences, , Volume: 45, Issue:8, 2022
Can Berberine Serve as a New Therapy for Parkinson's Disease?Neurotoxicity research, , Volume: 40, Issue:4, 2022
MALAT1 lncRNA and Parkinson's Disease: The role in the Pathophysiology and Significance for Diagnostic and Therapeutic Approaches.Molecular neurobiology, , Volume: 59, Issue:9, 2022
Glycation of α-synuclein hampers its binding to synaptic-like vesicles and its driving effect on their fusion.Cellular and molecular life sciences : CMLS, , Jun-04, Volume: 79, Issue:6, 2022
Inflammatory Animal Models of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
Altered hydroxymethylome in the substantia nigra of Parkinson's disease.Human molecular genetics, , 10-10, Volume: 31, Issue:20, 2022
The relevance of synuclein autoantibodies as a biomarker for Parkinson's disease.Molecular and cellular neurosciences, , Volume: 121, 2022
Myricetin Inhibits α-Synuclein Amyloid Aggregation by Delaying the Liquid-to-Solid Phase Transition.Chembiochem : a European journal of chemical biology, , 08-17, Volume: 23, Issue:16, 2022
An analytical solution simulating growth of Lewy bodies.Mathematical medicine and biology : a journal of the IMA, , 09-08, Volume: 39, Issue:3, 2022
The intestinal luminal sources of α-synuclein: a gastroenterologist perspective.Nutrition reviews, , 01-10, Volume: 80, Issue:2, 2022
Exploration of the α-syn/T199678/miR-519-3p/KLF9 pathway in a PD-related α-syn pathology.Brain research bulletin, , Volume: 186, 2022
Mechanistic insights into accelerated α-synuclein aggregation mediated by human microbiome-associated functional amyloids.The Journal of biological chemistry, , Volume: 298, Issue:7, 2022
Empagliflozin alleviates endoplasmic reticulum stress and augments autophagy in rotenone-induced Parkinson's disease in rats: Targeting the GRP78/PERK/eIF2α/CHOP pathway and miR-211-5p.Chemico-biological interactions, , Aug-01, Volume: 362, 2022
Modeling Parkinson's disease-related symptoms in alpha-synuclein overexpressing mice.Brain and behavior, , Volume: 12, Issue:7, 2022
Skin alpha-synuclein deposit patterns: A predictor of Parkinson's disease subtypes.EBioMedicine, , Volume: 80, 2022
Novel insights into the role of circular RNAs in Parkinson disease: An emerging renaissance in the management of neurodegenerative diseases.Journal of neuroscience research, , Volume: 100, Issue:9, 2022
Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers.Fluids and barriers of the CNS, , May-30, Volume: 19, Issue:1, 2022
Neuroprotective Effects of Cranberry Juice Treatment in a Rat Model of Parkinson's Disease.Nutrients, , May-11, Volume: 14, Issue:10, 2022
Association between Decreased ITGA7 Levels and Increased Muscle α-Synuclein in an MPTP-Induced Mouse Model of Parkinson's Disease.International journal of molecular sciences, , May-18, Volume: 23, Issue:10, 2022
Modelling α-Synuclein Aggregation and Neurodegeneration with Fibril Seeds in Primary Cultures of Mouse Dopaminergic Neurons.Cells, , 05-13, Volume: 11, Issue:10, 2022
Extracellular Alpha-Synuclein: Mechanisms for Glial Cell Internalization and Activation.Biomolecules, , 04-30, Volume: 12, Issue:5, 2022
Comparative Analysis of the Relative Fragmentation Stabilities of Polymorphic Alpha-Synuclein Amyloid Fibrils.Biomolecules, , 04-25, Volume: 12, Issue:5, 2022
Emerging urinary alpha-synuclein and miRNA biomarkers in Parkinson's disease.Metabolic brain disease, , Volume: 37, Issue:6, 2022
The promise of amplification assays for accurate early detection of α-synucleinopathies: A review.Experimental gerontology, , Volume: 165, 2022
Beyond neurodegenerative diseases: α-synuclein in erythropoiesis.Hematology (Amsterdam, Netherlands), , Volume: 27, Issue:1, 2022
Library-Derived Peptide Aggregation Modulators of Parkinson's Disease Early-Onset α-Synuclein Variants.ACS chemical neuroscience, , 06-15, Volume: 13, Issue:12, 2022
Altered Motor Performance, Sleep EEG, and Parkinson's Disease Pathology Induced by Chronic Sleep Deprivation in Lrrk2Neuroscience bulletin, , Volume: 38, Issue:10, 2022
Association between probable REM sleep behavior disorder and increased dermal alpha-synuclein deposition in Parkinson's disease.Parkinsonism & related disorders, , Volume: 99, 2022
A breakdown in microglial metabolic reprogramming causes internalization dysfunction of α-synuclein in a mouse model of Parkinson's disease.Journal of neuroinflammation, , May-22, Volume: 19, Issue:1, 2022
Parkinson's Disease Derived Exosomes Aggravate Neuropathology in SNCA*A53T Mice.Annals of neurology, , Volume: 92, Issue:2, 2022
Advances in Hydrogel-Based Drug Delivery Systems for Parkinson's Disease.Neurochemical research, , Volume: 47, Issue:8, 2022
Treating Parkinson's Disease via Activation of BDNF/TrkB Signaling Pathways and Inhibition of Delta-Secretase.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 19, Issue:4, 2022
Combined CSF α-SYN RT-QuIC, CSF NFL and midbrain-pons planimetry in degenerative parkinsonisms: From bedside to bench, and back again.Parkinsonism & related disorders, , Volume: 99, 2022
Loss of GBA in zebrafish leads to dopaminergic neurodegeneration, but overexpression of α-synuclein does not further worsen degeneration.Neuroreport, , 05-04, Volume: 33, Issue:7, 2022
circ-Pank1 promotes dopaminergic neuron neurodegeneration through modulating miR-7a-5p/α-syn pathway in Parkinson's disease.Cell death & disease, , 05-19, Volume: 13, Issue:5, 2022
Cholecystokinin and glucagon-like peptide-1 analogues regulate intestinal tight junction, inflammation, dopaminergic neurons and α-synuclein accumulation in the colon of two Parkinson's disease mouse models.European journal of pharmacology, , Jul-05, Volume: 926, 2022
Hybrids of polyphenolic acids and xanthone, the potential preventive and therapeutic effects on PD: Design, synthesis, in vitro anti-aggregation of α-synuclein, and disaggregation against the existed α-synuclein oligomer and fibril.Bioorganic & medicinal chemistry, , 07-15, Volume: 66, 2022
Exploring the multifactorial aspects of Gut Microbiome in Parkinson's Disease.Folia microbiologica, , Volume: 67, Issue:5, 2022
A novel high-throughput screening strategy for targeting alpha-synuclein and other long-lived proteins.SLAS discovery : advancing life sciences R & D, , Volume: 27, Issue:6, 2022
Effect of an Amyloidogenic SARS-COV-2 Protein Fragment on α-Synuclein Monomers and Fibrils.The journal of physical chemistry. B, , 05-26, Volume: 126, Issue:20, 2022
NADPH oxidase 2 activity in Parkinson's disease.Neurobiology of disease, , Volume: 170, 2022
New Insights and Implications of Natural Killer Cells in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
A case series of cutaneous phosphorylated α-synuclein in Long-COVID POTS.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 32, Issue:3, 2022
Alpha-synuclein overexpression induces epigenomic dysregulation of glutamate signaling and locomotor pathways.Human molecular genetics, , 10-28, Volume: 31, Issue:21, 2022
Overlap between Central and Peripheral Transcriptomes in Parkinson's Disease but Not Alzheimer's Disease.International journal of molecular sciences, , May-06, Volume: 23, Issue:9, 2022
Pathophysiological Features of Nigral Dopaminergic Neurons in Animal Models of Parkinson's Disease.International journal of molecular sciences, , Apr-19, Volume: 23, Issue:9, 2022
Ulvan inhibits α-synuclein fibrillation and disrupts the mature fibrils: In vitro and in vivo studies.International journal of biological macromolecules, , Jun-30, Volume: 211, 2022
Detection and assessment of alpha-synuclein in Parkinson disease.Neurochemistry international, , Volume: 158, 2022
Tau accelerates α-synuclein aggregation and spreading in Parkinson's disease.Brain : a journal of neurology, , 10-21, Volume: 145, Issue:10, 2022
Lipid pathway dysfunction is prevalent in patients with Parkinson's disease.Brain : a journal of neurology, , 10-21, Volume: 145, Issue:10, 2022
Chitosan oligosaccharides exert neuroprotective effects Food & function, , May-23, Volume: 13, Issue:10, 2022
Comparative Analysis of Total Alpha-Synuclein (αSYN) Immunoassays Reveals That They Do Not Capture the Diversity of Modified αSYN Proteoforms.Journal of Parkinson's disease, , Volume: 12, Issue:5, 2022
The proSAAS Chaperone Provides Neuroprotection and Attenuates Transsynaptic α-Synuclein Spread in Rodent Models of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:5, 2022
Hytrin loaded polydopamine-serotonin nanohybrid induces IDH2 mediated neuroprotective effect to alleviate Parkinson's disease.Biomaterials advances, , Volume: 133, 2022
α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 101, 2022
The Gut-Brain Axis: Two Ways Signaling in Parkinson's Disease.Cellular and molecular neurobiology, , Volume: 42, Issue:2, 2022
Dopaminergic Positron Emission Tomography Imaging in the Alpha-Synuclein Preformed Fibril Model Reveals Similarities to Early Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:8, 2022
Evidence for immune system alterations in peripheral biological fluids in Parkinson's disease.Neurobiology of disease, , Volume: 170, 2022
Vocal changes in a zebra finch model of Parkinson's disease characterized by alpha-synuclein overexpression in the song-dedicated anterior forebrain pathway.PloS one, , Volume: 17, Issue:5, 2022
Raman Spectroscopy Study of Skin Biopsies from Patients with Parkinson's Disease: Trends in Alpha-Synuclein Aggregation from the Amide I Region.Applied spectroscopy, , Volume: 76, Issue:11, 2022
Exploring the Role of Ubiquitin-Proteasome System in Parkinson's Disease.Molecular neurobiology, , Volume: 59, Issue:7, 2022
Evolution of α-synuclein conformation ensemble toward amyloid fibril via liquid-liquid phase separation (LLPS) as investigated by dynamic nuclear polarization-enhanced solid-state MAS NMR.Neurochemistry international, , Volume: 157, 2022
Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial.EBioMedicine, , Volume: 80, 2022
Disease-Modifying Therapies for Multiple System Atrophy: Where Are We in 2022?Journal of Parkinson's disease, , Volume: 12, Issue:5, 2022
A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity.Science advances, , 04-29, Volume: 8, Issue:17, 2022
α-Synuclein phase separation and amyloid aggregation are modulated by C-terminal truncations.FEBS letters, , Volume: 596, Issue:11, 2022
Elevated α-synuclein and NfL levels in tear fluids and decreased retinal microvascular densities in patients with Parkinson's disease.GeroScience, , Volume: 44, Issue:3, 2022
Misfolded GBA/β-glucocerebrosidase impairs ER-quality control by chaperone-mediated autophagy in Parkinson disease.Autophagy, , Volume: 18, Issue:12, 2022
Foldamers reveal and validate therapeutic targets associated with toxic α-synuclein self-assembly.Nature communications, , 04-27, Volume: 13, Issue:1, 2022
Design, Synthesis, and Biological Evaluation of Potent 20S Proteasome Activators for the Potential Treatment of α-Synucleinopathies.Journal of medicinal chemistry, , 05-12, Volume: 65, Issue:9, 2022
Mechanisms of enhanced aggregation and fibril formation of Parkinson's disease-related variants of α-synuclein.Scientific reports, , 04-26, Volume: 12, Issue:1, 2022
Reduction of the α-synuclein expression promotes slowing down early neuropathology development in the Journal of neurogenetics, , Volume: 36, Issue:1, 2022
7,8-Dihydroxyflavone ameliorates mitochondrial impairment and motor dysfunction in the α-synuclein 1-103 transgenic mice.Neurobiology of disease, , Volume: 169, 2022
Binding Stability of Antibody-α-Synuclein Complexes Predicts the Protective Efficacy of Anti-α-synuclein Antibodies.Molecular neurobiology, , Volume: 59, Issue:7, 2022
A Novel NOX Inhibitor Treatment Attenuates Parkinson's Disease-Related Pathology in Mouse Models.International journal of molecular sciences, , Apr-12, Volume: 23, Issue:8, 2022
[no title available]Cells, , 04-08, Volume: 11, Issue:8, 2022
Cell Culture Media, Unlike the Presence of Insulin, Affect α-Synuclein Aggregation in Dopaminergic Neurons.Biomolecules, , 04-09, Volume: 12, Issue:4, 2022
α-Synuclein at the Presynaptic Axon Terminal as a Double-Edged Sword.Biomolecules, , 03-27, Volume: 12, Issue:4, 2022
The understanding of Parkinson's disease through genetics and new therapies.Brain and behavior, , Volume: 12, Issue:5, 2022
GM1 ganglioside modifies microglial and neuroinflammatory responses to α-synuclein in the rat AAV-A53T α-synuclein model of Parkinson's disease.Molecular and cellular neurosciences, , Volume: 120, 2022
Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases.Progress in neurobiology, , Volume: 214, 2022
Alpha-synuclein-mediated DNA damage, STING activation, and neuroinflammation in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 04-26, Volume: 119, Issue:17, 2022
A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 19, Issue:3, 2022
Regional changes of brain structure during progression of idiopathic Parkinson's disease - A longitudinal study using deformation based morphometry.Cortex; a journal devoted to the study of the nervous system and behavior, , Volume: 151, 2022
SNCA-AS1 in aging and Parkinson's disease.Aging, , 04-18, Volume: 14, Issue:8, 2022
The Two Faces of Exosomes in Parkinson's Disease: From Pathology to Therapy.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, , Volume: 28, Issue:2, 2022
Blood-based biomarker in Parkinson's disease: potential for future applications in clinical research and practice.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 129, Issue:9, 2022
REM sleep behavior disorder and cerebrospinal fluid alpha-synuclein, amyloid beta, total tau and phosphorylated tau in Parkinson's disease: a cross-sectional and longitudinal study.Journal of neurology, , Volume: 269, Issue:9, 2022
A Randomized First-in-Human Study With UB-312, a UBITh® α-Synuclein Peptide Vaccine.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:7, 2022
Differentiating dementia with Lewy bodies from Alzheimer's disease and Parkinson's disease dementia: an update on imaging modalities.Journal of neurology, , Volume: 269, Issue:2, 2022
Structural and mechanistic insights into modulation of α-Synuclein fibril formation by aloin and emodin.Biochimica et biophysica acta. General subjects, , Volume: 1866, Issue:7, 2022
The GBA1 D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models.Disease models & mechanisms, , 06-01, Volume: 15, Issue:6, 2022
[Morphochemical study of alpha-synuclein, iron and iron-containing proteins in the substantia nigra of the brain in Parkinson's disease].Arkhiv patologii, , Volume: 84, Issue:2, 2022
Single-Particle Resolution of Copper-Associated Annular α-Synuclein Oligomers Reveals Potential Therapeutic Targets of Neurodegeneration.ACS chemical neuroscience, , 05-04, Volume: 13, Issue:9, 2022
Sesquiterpenoids isolated from davana (Artemisia pallens Wall. ex DC) mitigates parkinsonism in Caenorhabditis elegans disease model.Biochemical and biophysical research communications, , 06-18, Volume: 609, 2022
Understanding the Inhibitory and Antioxidant Effects of Pyrroloquinoline Quinone (PQQ) on Copper(II)-Induced α-Synuclein-119 Aggregation.ACS chemical neuroscience, , 04-20, Volume: 13, Issue:8, 2022
Immune Response Modifications in the Genetic Forms of Parkinson's Disease: What Do We Know?International journal of molecular sciences, , Mar-23, Volume: 23, Issue:7, 2022
Insights into the inhibitory mechanism of skullcapflavone II against α-synuclein aggregation and its mediated cytotoxicity.International journal of biological macromolecules, , Jun-01, Volume: 209, Issue:Pt A, 2022
LncRNA HOTAIR promotes α-synuclein aggregation and apoptosis of SH-SY5Y cells by regulating miR-221-3p in Parkinson's disease.Experimental cell research, , 08-01, Volume: 417, Issue:1, 2022
A53T mutant α-synuclein fibrils formed in macrophage are spread to neurons.Cellular and molecular life sciences : CMLS, , Apr-10, Volume: 79, Issue:5, 2022
Alpha-synucleinopathy reduces NMNAT3 protein levels and neurite formation that can be rescued by targeting the NAD+ pathway.Human molecular genetics, , 08-25, Volume: 31, Issue:17, 2022
α-Synuclein arginylation in the human brain.Translational neurodegeneration, , 04-08, Volume: 11, Issue:1, 2022
Genetic heterogeneity on sleep disorders in Parkinson's disease: a systematic review and meta-analysis.Translational neurodegeneration, , 04-08, Volume: 11, Issue:1, 2022
Poly (ADP-Ribose) and α-synuclein extracellular vesicles in patients with Parkinson disease: A possible biomarker of disease severity.PloS one, , Volume: 17, Issue:4, 2022
Change in the Oligomeric State of α-Synuclein Variants in Living Cells.ACS chemical neuroscience, , 04-20, Volume: 13, Issue:8, 2022
The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains.The Journal of biological chemistry, , Volume: 298, Issue:5, 2022
Rationally designed helical peptidomimetics disrupt α-synuclein fibrillation.Chemical communications (Cambridge, England), , Apr-21, Volume: 58, Issue:33, 2022
Fatty acid balance regulates α-synuclein pathology.Trends in neurosciences, , Volume: 45, Issue:6, 2022
Neuropathology of α-synuclein in Parkinson's disease.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 42, Issue:2, 2022
Sphingolipid changes in Parkinson L444P GBA mutation fibroblasts promote α-synuclein aggregation.Brain : a journal of neurology, , 04-29, Volume: 145, Issue:3, 2022
O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies.ACS chemical neuroscience, , 04-20, Volume: 13, Issue:8, 2022
α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity.Proceedings of the National Academy of Sciences of the United States of America, , 04-12, Volume: 119, Issue:15, 2022
Distribution of α-Synuclein Aggregation in the Peripheral Tissues.Neurochemical research, , Volume: 47, Issue:12, 2022
Initiation and progression of α-synuclein pathology in Parkinson's disease.Cellular and molecular life sciences : CMLS, , Mar-26, Volume: 79, Issue:4, 2022
Chicago sky blue 6B inhibits α-synuclein aggregation and propagation.Molecular brain, , 03-28, Volume: 15, Issue:1, 2022
Relationships of Nutritional Factors and Agrochemical Exposure with Parkinson's Disease in the Province of Brescia, Italy.International journal of environmental research and public health, , 03-11, Volume: 19, Issue:6, 2022
SARS-CoV-2 Proteins Interact with Alpha Synuclein and Induce Lewy Body-like Pathology In Vitro.International journal of molecular sciences, , Mar-21, Volume: 23, Issue:6, 2022
The Role of NEDD4 E3 Ubiquitin-Protein Ligases in Parkinson's Disease.Genes, , 03-14, Volume: 13, Issue:3, 2022
Alpha-Synuclein-Specific Naturally Occurring Antibodies Inhibit Aggregation In Vitro and In Vivo.Biomolecules, , 03-18, Volume: 12, Issue:3, 2022
Endogenous Human Proteins Interfering with Amyloid Formation.Biomolecules, , 03-14, Volume: 12, Issue:3, 2022
Leukotriene Signaling as a Target in α-Synucleinopathies.Biomolecules, , 02-23, Volume: 12, Issue:3, 2022
Hydrogen Sulfide Produced by Gut Bacteria May Induce Parkinson's Disease.Cells, , 03-12, Volume: 11, Issue:6, 2022
Acidic nanoparticles protect against α-synuclein-induced neurodegeneration through the restoration of lysosomal function.Aging cell, , Volume: 21, Issue:4, 2022
Nano-MgO composites containing plasmid DNA to silence SNCA gene displays neuroprotective effects in Parkinson's rats induced by 6-hydroxydopamine.European journal of pharmacology, , May-05, Volume: 922, 2022
Paraquat Inhibits Autophagy Via Intensifying the Interaction Between HMGB1 and α-Synuclein.Neurotoxicity research, , Volume: 40, Issue:2, 2022
Sustained chemogenetic activation of locus coeruleus norepinephrine neurons promotes dopaminergic neuron survival in synucleinopathy.PloS one, , Volume: 17, Issue:3, 2022
Immune responses in the Parkinson's disease brain.Neurobiology of disease, , 06-15, Volume: 168, 2022
Celastrol Downmodulates Alpha-Synuclein-Specific T Cell Responses by Mediating Antigen Trafficking in Dendritic Cells.Frontiers in immunology, , Volume: 13, 2022
Synthesis of Evodileptin B, a Natural Anthranilate Derivative Isolated from Evodia lepta, and Evaluation of Its Therapeutic Potential against Parkinson's Disease.Chemistry & biodiversity, , Volume: 19, Issue:5, 2022
Immunotherapeutic interventions in Parkinson's disease: Focus on α-Synuclein.Advances in protein chemistry and structural biology, , Volume: 129, 2022
α-Synuclein binding activity of the plant growth promoter asterubine.Bioorganic & medicinal chemistry letters, , 05-15, Volume: 64, 2022
Synthesis and evaluation of novel radioiodinated phenylbenzofuranone derivatives as α-synuclein imaging probes.Bioorganic & medicinal chemistry letters, , 05-15, Volume: 64, 2022
Parkinson's disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein-induced changes in maturation and immune reactive properties.Proceedings of the National Academy of Sciences of the United States of America, , 03-22, Volume: 119, Issue:12, 2022
CIITA expression is regulated by histone deacetylase enzymes and has a role in α-synuclein pre-formed fibril-induced antigen presentation in murine microglial cell line.Immunopharmacology and immunotoxicology, , Volume: 44, Issue:3, 2022
α-Synuclein Radiotracer Development and In Vivo Imaging: Recent Advancements and New Perspectives.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:5, 2022
Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models.Autophagy, , Volume: 18, Issue:5, 2022
Single Molecule Fingerprinting Reveals Different Amplification Properties of α-Synuclein Oligomers and Preformed Fibrils in Seeding Assay.ACS chemical neuroscience, , 04-06, Volume: 13, Issue:7, 2022
Brain injections of glial cytoplasmic inclusions induce a multiple system atrophy-like pathology.Brain : a journal of neurology, , 04-29, Volume: 145, Issue:3, 2022
The roles of connectivity and neuronal phenotype in determining the pattern of α-synuclein pathology in Parkinson's disease.Neurobiology of disease, , 06-15, Volume: 168, 2022
Comparison of commercially available antibodies for the detection of phosphorylated alpha-synuclein in primary culture of ENS.Neurogastroenterology and motility, , Volume: 34, Issue:6, 2022
Diagnostic Value of Salivary Real-Time Quaking-Induced Conversion in Parkinson's Disease and Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:5, 2022
Cardiac Alpha-Synuclein Is Present in Alpha-Synucleinopathies.Journal of Parkinson's disease, , Volume: 12, Issue:4, 2022
Crocin Protects Malathion-Induced Striatal Biochemical Deficits by Inhibiting Apoptosis and Increasing α-Synuclein in Rats' Striatum.Journal of molecular neuroscience : MN, , Volume: 72, Issue:5, 2022
Synuclein-One study: skin biopsy detection of phosphorylated α-synuclein for diagnosis of synucleinopathies.Biomarkers in medicine, , Volume: 16, Issue:7, 2022
Pathological Relevance of Post-Translationally Modified Alpha-Synuclein (pSer87, pSer129, nTyr39) in Idiopathic Parkinson's Disease and Multiple System Atrophy.Cells, , 03-06, Volume: 11, Issue:5, 2022
LRRK2 Inhibition Mitigates the Neuroinflammation Caused by TLR2-Specific α-Synuclein and Alleviates Neuroinflammation-Derived Dopaminergic Neuronal Loss.Cells, , 03-02, Volume: 11, Issue:5, 2022
Transcellular propagation of fibrillar α-synuclein from enteroendocrine to neuronal cells requires cell-to-cell contact and is Rab35-dependent.Scientific reports, , 03-09, Volume: 12, Issue:1, 2022
Isogenic human SNCA gene dosage induced pluripotent stem cells to model Parkinson's disease.Stem cell research, , Volume: 60, 2022
A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson disease.PLoS biology, , Volume: 20, Issue:3, 2022
Low dose DMSO treatment induces oligomerization and accelerates aggregation of α-synuclein.Scientific reports, , 03-08, Volume: 12, Issue:1, 2022
[Autonomic Dysfunction in Lewy Body Disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 74, Issue:3, 2022
Ferroptosis in Parkinson's disease: glia-neuron crosstalk.Trends in molecular medicine, , Volume: 28, Issue:4, 2022
Pathophysiological significance of increased α-synuclein deposition in sympathetic nerves in Parkinson's disease: a post-mortem observational study.Translational neurodegeneration, , 03-08, Volume: 11, Issue:1, 2022
Long-term hyperglycemia aggravates α-synuclein aggregation and dopaminergic neuronal loss in a Parkinson's disease mouse model.Translational neurodegeneration, , 03-07, Volume: 11, Issue:1, 2022
Gene therapy of yeast NDI1 on mitochondrial complex I dysfunction in rotenone-induced Parkinson's disease models in vitro and vivo.Molecular medicine (Cambridge, Mass.), , 03-07, Volume: 28, Issue:1, 2022
Neuronal Presentation of Antigen and Its Possible Role in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
PTEN-Induced Putative Kinase 1 Dysfunction Accelerates Synucleinopathy.Journal of Parkinson's disease, , Volume: 12, Issue:4, 2022
Striatal synaptic bioenergetic and autophagic decline in premotor experimental parkinsonism.Brain : a journal of neurology, , 06-30, Volume: 145, Issue:6, 2022
Ferulic Acid Exerts Neuroprotective Effects via Autophagy Induction in Oxidative medicine and cellular longevity, , Volume: 2022, 2022
Plasma α-synuclein and phosphorylated tau 181 as a diagnostic biomarker panel for de novo Parkinson's disease.Journal of neurochemistry, , Volume: 161, Issue:6, 2022
Pharmacological Intervention Targeting FAF1 Restores Autophagic Flux for α-Synuclein Degradation in the Brain of a Parkinson's Disease Mouse Model.ACS chemical neuroscience, , 03-16, Volume: 13, Issue:6, 2022
Tailoring a Nanochaperone to Regulate α-Synuclein Assembly.Angewandte Chemie (International ed. in English), , 05-02, Volume: 61, Issue:19, 2022
Ferritinophagy and α-Synuclein: Pharmacological Targeting of Autophagy to Restore Iron Regulation in Parkinson's Disease.International journal of molecular sciences, , Feb-21, Volume: 23, Issue:4, 2022
Sequential or Simultaneous Injection of Preformed Fibrils and AAV Overexpression of Alpha-Synuclein Are Equipotent in Producing Relevant Pathology and Behavioral Deficits.Journal of Parkinson's disease, , Volume: 12, Issue:4, 2022
Slowing Parkinson's Disease Progression with Vaccination and Other Immunotherapies.CNS drugs, , Volume: 36, Issue:4, 2022
Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson's disease.Scientific reports, , 02-24, Volume: 12, Issue:1, 2022
Ischemic stroke causes Parkinson's disease-like pathology and symptoms in transgenic mice overexpressing alpha-synuclein.Acta neuropathologica communications, , 02-24, Volume: 10, Issue:1, 2022
Update on CSF Biomarkers in Parkinson's Disease.Biomolecules, , 02-18, Volume: 12, Issue:2, 2022
How Lazy Reading and Semantic Sloppiness May Harm Progress in Synucleinopathy Research.Biomolecules, , 01-28, Volume: 12, Issue:2, 2022
Unique Lewy pathology in myotonic dystrophy type 1.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 42, Issue:2, 2022
Cytokines, miRNAs, and Antioxidants as Combined Non-invasive Biomarkers for Parkinson's Disease.Journal of molecular neuroscience : MN, , Volume: 72, Issue:5, 2022
Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson's disease.Molecular neurodegeneration, , 02-23, Volume: 17, Issue:1, 2022
Is a cure for Parkinson's disease hiding inside us?Trends in biochemical sciences, , Volume: 47, Issue:8, 2022
α-Synuclein-containing erythrocytic extracellular vesicles: essential contributors to hyperactivation of monocytes in Parkinson's disease.Journal of neuroinflammation, , Feb-22, Volume: 19, Issue:1, 2022
CRISPR-Cas9 Gene Editing Protects from the A53T-SNCA Overexpression-Induced Pathology of Parkinson's Disease The CRISPR journal, , Volume: 5, Issue:1, 2022
Generation of an induced pluripotent stem cell line (EURACi014-A) from a Parkinson's disease patient with an A53T mutation in the SNCA gene by an integration-free reprogramming method.Stem cell research, , Volume: 60, 2022
Glucocerebrosidase-associated Parkinson disease: Pathogenic mechanisms and potential drug treatments.Neurobiology of disease, , Volume: 166, 2022
Lysosomal ceramides regulate cathepsin B-mediated processing of saposin C and glucocerebrosidase activity.Human molecular genetics, , 07-21, Volume: 31, Issue:14, 2022
Discovery of Neuroprotective Agents Based on a 5-(4-Pyridinyl)-1,2,4-triazole Scaffold.ACS chemical neuroscience, , 03-02, Volume: 13, Issue:5, 2022
Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor impairment and cortical dysfunction, independent of protein aggregation.Human molecular genetics, , 10-28, Volume: 31, Issue:21, 2022
Ambroxol reverses tau and α-synuclein accumulation in a cholinergic N370S GBA1 mutation model.Human molecular genetics, , 07-21, Volume: 31, Issue:14, 2022
α-Synuclein in Parkinson's disease and advances in detection.Clinica chimica acta; international journal of clinical chemistry, , Apr-01, Volume: 529, 2022
Gene Co-expression Analysis of the Human Substantia Nigra Identifies ZNHIT1 as an SNCA Co-expressed Gene that Protects Against α-Synuclein-Induced Impairments in Neurite Growth and Mitochondrial Dysfunction in SH-SY5Y Cells.Molecular neurobiology, , Volume: 59, Issue:5, 2022
Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological α-synuclein.Cell reports, , 02-15, Volume: 38, Issue:7, 2022
S-Nitrosylation of p62 Inhibits Autophagic Flux to Promote α-Synuclein Secretion and Spread in Parkinson's Disease and Lewy Body Dementia.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 04-06, Volume: 42, Issue:14, 2022
Current Progress in the Development of Probes for Targeting α-Synuclein Aggregates.ACS chemical neuroscience, , 03-02, Volume: 13, Issue:5, 2022
Predictive Modeling of Neurotoxic α-Synuclein Polymorphs.Methods in molecular biology (Clifton, N.J.), , Volume: 2340, 2022
Astrocytes expressing Vitamin D-activating enzyme identify Parkinson's disease.CNS neuroscience & therapeutics, , Volume: 28, Issue:5, 2022
α-Synuclein-activated microglia are implicated in PD pathogenesis.Nature reviews. Neurology, , Volume: 18, Issue:4, 2022
Interaction of Alpha Synuclein and Microtubule Organization Is Linked to Impaired Neuritic Integrity in Parkinson's Patient-Derived Neuronal Cells.International journal of molecular sciences, , Feb-05, Volume: 23, Issue:3, 2022
Roles of α-Synuclein and Disease-Associated Factors in International journal of molecular sciences, , Jan-28, Volume: 23, Issue:3, 2022
Fat and Protein Combat Triggers Immunological Weapons of Innate and Adaptive Immune Systems to Launch Neuroinflammation in Parkinson's Disease.International journal of molecular sciences, , Jan-19, Volume: 23, Issue:3, 2022
Characterization of molecular biomarkers in cerebrospinal fluid and serum of E46K-SNCA mutation carriers.Parkinsonism & related disorders, , Volume: 96, 2022
In vivo imaging of alpha-synuclein with antibody-based PET.Neuropharmacology, , 05-01, Volume: 208, 2022
The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization.Communications biology, , 02-10, Volume: 5, Issue:1, 2022
Association Between Pathophysiological Mechanisms of Diabetic Retinopathy and Parkinson's Disease.Cellular and molecular neurobiology, , Volume: 42, Issue:3, 2022
Upregulation of α-synuclein following immune activation: Possible trigger of Parkinson's disease.Neurobiology of disease, , Volume: 166, 2022
Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations.Acta neuropathologica, , Volume: 143, Issue:4, 2022
Adenosine A1 receptor ligands bind to α-synuclein: implications for α-synuclein misfolding and α-synucleinopathy in Parkinson's disease.Translational neurodegeneration, , 02-10, Volume: 11, Issue:1, 2022
LncRNA miR-17-92a-1 cluster host gene (MIR17HG) promotes neuronal damage and microglial activation by targeting the microRNA-153-3p/alpha-synuclein axis in Parkinson's disease.Bioengineered, , Volume: 13, Issue:2, 2022
Senescence and impaired DNA damage responses in alpha-synucleinopathy models.Experimental & molecular medicine, , Volume: 54, Issue:2, 2022
Insulin-like growth factor 2 and autophagy gene expression alteration arise as potential biomarkers in Parkinson's disease.Scientific reports, , 02-07, Volume: 12, Issue:1, 2022
Doxorubicin induced aggregation of α-synuclein: Insights into the mechanism of drug induced Parkinsonism.Colloids and surfaces. B, Biointerfaces, , Volume: 212, 2022
Modeling the cellular fate of alpha-synuclein aggregates: A pathway to pathology.Current opinion in neurobiology, , Volume: 72, 2022
Alpha and Beta Synucleins: From Pathophysiology to Clinical Application as Biomarkers.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:4, 2022
Anti-α-synuclein Toxicity and Anti-neurodegenerative Role of Chrysin in Transgenic ACS chemical neuroscience, , 02-16, Volume: 13, Issue:4, 2022
Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy.Proceedings of the National Academy of Sciences of the United States of America, , 02-08, Volume: 119, Issue:6, 2022
Living in α-syn: Tackling aggregates in Parkinson's disease.Neuron, , 02-02, Volume: 110, Issue:3, 2022
Inhibition-mediated changes in prolyl oligopeptidase dynamics possibly related to α-synuclein aggregation.Physical chemistry chemical physics : PCCP, , Feb-16, Volume: 24, Issue:7, 2022
Lysophosphatidylcholine acyltransferase 1 promotes pathology and toxicity in two distinct cell-based alpha-synuclein models.Neuroscience letters, , 02-16, Volume: 772, 2022
Assessment of Glucocerebrosidase Enzyme Activity in Parkinson Disease Using Multiple Approaches.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:3, 2022
Alpha-synuclein negatively controls cell proliferation in dopaminergic neurons.Molecular and cellular neurosciences, , Volume: 119, 2022
Neurodegeneration and neuroinflammation are linked, but independent of alpha-synuclein inclusions, in a seeding/spreading mouse model of Parkinson's disease.Glia, , Volume: 70, Issue:5, 2022
The mitochondrial protein Sideroflexin 3 (SFXN3) influences neurodegeneration pathways in vivo.The FEBS journal, , Volume: 289, Issue:13, 2022
Novel engineered nanobodies specific for N-terminal region of alpha-synuclein recognize Lewy-body pathology and inhibit in-vitro seeded aggregation and toxicity.The FEBS journal, , Volume: 289, Issue:15, 2022
Age-dependent aggregation of α-synuclein in the nervous system of gut-brain axis is associated with caspase-1 activation.Metabolic brain disease, , Volume: 37, Issue:5, 2022
Pathogenic Mechanisms of Cytosolic and Membrane-Enriched α-Synuclein Converge on Fatty Acid Homeostasis.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 03-09, Volume: 42, Issue:10, 2022
Repurposing Pomalidomide as a Neuroprotective Drug: Efficacy in an Alpha-Synuclein-Based Model of Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 19, Issue:1, 2022
Longitudinal Study of SNCA Rep1 Polymorphism on Executive Function in Early Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:3, 2022
Olfactory Bulb Excitotoxicity as a Gap-Filling Mechanism Underlying the Link Between Traumatic Brain Injury-Induced Secondary Neuronal Degeneration and Parkinson's Disease-Like Pathology.Neurochemical research, , Volume: 47, Issue:4, 2022
Impaired Sphingolipid Hydrolase Activities in Dementia with Lewy Bodies and Multiple System Atrophy.Molecular neurobiology, , Volume: 59, Issue:4, 2022
Gaucher disease - more than just a rare lipid storage disease.Journal of molecular medicine (Berlin, Germany), , Volume: 100, Issue:4, 2022
Buffering capacity is determinant for restoring early α-synuclein aggregation.Biophysical chemistry, , Volume: 282, 2022
High-Sensitivity Single Molecule Array Assays for Pathological Isoforms in Parkinson's Disease.Clinical chemistry, , 03-04, Volume: 68, Issue:3, 2022
[Aggregation and spread of synuclein in Parkinson's disease].Medecine sciences : M/S, , Volume: 38, Issue:1, 2022
Non-clinical Pharmacology of YTX-7739: a Clinical Stage Stearoyl-CoA Desaturase Inhibitor Being Developed for Parkinson's Disease.Molecular neurobiology, , Volume: 59, Issue:4, 2022
β-Synuclein: An Enigmatic Protein with Diverse Functionality.Biomolecules, , 01-16, Volume: 12, Issue:1, 2022
Insights into the Interactions that Trigger the Primary Nucleation of Polymorphic α-Synuclein Dimers.ACS chemical neuroscience, , 02-02, Volume: 13, Issue:3, 2022
α-synuclein-assisted oligomerization of β-amyloid (1-42).Archives of biochemistry and biophysics, , 03-15, Volume: 717, 2022
Subthalamic deep brain stimulation in Parkinson's disease with SNCA mutations: Based on the follow-up to 10 years.Brain and behavior, , Volume: 12, Issue:2, 2022
Infectious Agents as Potential Drivers of α-Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:3, 2022
Drosophila: A Model to Study the Pathogenesis of Parkinson's Disease.CNS & neurological disorders drug targets, , Volume: 21, Issue:3, 2022
Synapsin III gene silencing redeems alpha-synuclein transgenic mice from Parkinson's disease-like phenotype.Molecular therapy : the journal of the American Society of Gene Therapy, , 04-06, Volume: 30, Issue:4, 2022
T cells, α-synuclein and Parkinson disease.Handbook of clinical neurology, , Volume: 184, 2022
Alpha-synuclein and cortico-striatal plasticity in animal models of Parkinson disease.Handbook of clinical neurology, , Volume: 184, 2022
Clinical and imaging evidence of brain-first and body-first Parkinson's disease.Neurobiology of disease, , Volume: 164, 2022
Controlled Activation of TRPV1 Channels on Microglia to Boost Their Autophagy for Clearance of Alpha-Synuclein and Enhance Therapy of Parkinson's Disease.Advanced materials (Deerfield Beach, Fla.), , Volume: 34, Issue:11, 2022
A Matrigel-based 3D construct of SH-SY5Y cells models the α-synuclein pathologies of Parkinson's disease.Disease models & mechanisms, , 03-01, Volume: 15, Issue:3, 2022
Chemoselective Bioconjugation of Amyloidogenic Protein Antigens to PEGylated Microspheres Enables Detection of α-Synuclein Autoantibodies in Human Plasma.Bioconjugate chemistry, , 02-16, Volume: 33, Issue:2, 2022
Combining Skin α-Synuclein Real-Time Quaking-Induced Conversion and Circulating Neurofilament Light Chain to Distinguish Multiple System Atrophy and Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:3, 2022
Therapeutics in the Pipeline Targeting Pharmacological reviews, , Volume: 74, Issue:1, 2022
Two-step screening method to identify α-synuclein aggregation inhibitors for Parkinson's disease.Scientific reports, , 01-10, Volume: 12, Issue:1, 2022
Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain.Molecular neurodegeneration, , 01-10, Volume: 17, Issue:1, 2022
Strong Predictive Algorithm of Pathogenesis-Based Biomarkers Improves Parkinson's Disease Diagnosis.Molecular neurobiology, , Volume: 59, Issue:3, 2022
Roflupram attenuates α-synuclein-induced cytotoxicity and promotes the mitochondrial translocation of Parkin in SH-SY5Y cells overexpressing A53T mutant α-synuclein.Toxicology and applied pharmacology, , 02-01, Volume: 436, 2022
Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells.Molecular neurobiology, , Volume: 59, Issue:2, 2022
Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A): Could It Be a Promising Biomarker and Therapeutic Target in Parkinson's Disease?Molecular neurobiology, , Volume: 59, Issue:2, 2022
Phosphorylated α-synuclein in diluted human serum as a biomarker for Parkinson's disease.Biomedical journal, , Volume: 45, Issue:6, 2022
Analysis of circulating metabolites to differentiate Parkinson's disease and essential tremor.Neuroscience letters, , 01-19, Volume: 769, 2022
Genetic modulators associated with regulatory surveillance of mitochondrial quality control, play a key role in regulating stress pathways and longevity in C. elegans.Life sciences, , Feb-01, Volume: 290, 2022
Animal models of brain-first and body-first Parkinson's disease.Neurobiology of disease, , Volume: 163, 2022
Digesting recent findings: gut alpha-synuclein, microbiome changes in Parkinson's disease.Trends in endocrinology and metabolism: TEM, , Volume: 33, Issue:2, 2022
Rapid Induction of Dopaminergic Neuron Loss Accompanied by Lewy Body-Like Inclusions in A53T BAC-SNCA Transgenic Mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 19, Issue:1, 2022
Wilful pathogens provoke a gut feeling in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 129, Issue:5-6, 2022
Intermediates of α-synuclein aggregation: Implications in Parkinson's disease pathogenesis.Biophysical chemistry, , Volume: 281, 2022
Association of plasma α-synuclein with cardiac Neuroscience letters, , 01-23, Volume: 770, 2022
Differentially targeted seeding reveals unique pathological alpha-synuclein propagation patterns.Brain : a journal of neurology, , 06-03, Volume: 145, Issue:5, 2022
Motor and non-motor circuit disturbances in early Parkinson disease: which happens first?Nature reviews. Neuroscience, , Volume: 23, Issue:2, 2022
Bioactive lipids and their metabolism: New therapeutic opportunities for Parkinson's disease.The European journal of neuroscience, , Volume: 55, Issue:3, 2022
Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies.Brain : a journal of neurology, , 04-18, Volume: 145, Issue:2, 2022
Can the lack of fibrillar form of alpha-synuclein in Lewy bodies be explained by its catalytic activity?Mathematical biosciences, , Volume: 344, 2022
Combination of liquid crystal and deep learning reveals distinct signatures of Parkinson's disease-related wild-type α-synuclein and six pathogenic mutants.Chemistry, an Asian journal, , Jan-17, Volume: 17, Issue:2, 2022
Presence of Skin α-Synuclein Deposits Discriminates Parkinson's Disease from Progressive Supranuclear Palsy and Corticobasal Syndrome.Journal of Parkinson's disease, , Volume: 12, Issue:2, 2022
Elevated norepinephrine may interact with alpha-synuclein to promote Parkinson's disease and DLB.Acta neurologica Scandinavica, , Volume: 145, Issue:1, 2022
[Hallucinations in Patients with Idiopathic Parkinson's Disease].Fortschritte der Neurologie-Psychiatrie, , Volume: 90, Issue:10, 2022
Intranasal Exposure to Low-Dose Rotenone Induced Alpha-Synuclein Accumulation and Parkinson's Like Symptoms Without Loss of Dopaminergic Neurons.Neurotoxicity research, , Volume: 40, Issue:1, 2022
The role of cardiovascular autonomic failure in the differential diagnosis of α-synucleinopathies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 43, Issue:1, 2022
Gastrointestinal mucosal biopsies in Parkinson's disease: beyond alpha-synuclein detection.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 129, Issue:9, 2022
The increase of α-synuclein and alterations of dynein in A53T transgenic and aging mouse.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, , Volume: 96, 2022
Impact of α-synuclein spreading on the nigrostriatal dopaminergic pathway depends on the onset of the pathology.Brain pathology (Zurich, Switzerland), , Volume: 32, Issue:2, 2022
Pathology-associated change in levels and localization of SIDT2 in postmortem brains of Parkinson's disease and dementia with Lewy bodies patients.Neurochemistry international, , Volume: 152, 2022
Rescue of α-synuclein aggregation in Parkinson's patient neurons by synergistic enhancement of ER proteostasis and protein trafficking.Neuron, , 02-02, Volume: 110, Issue:3, 2022
α-Synuclein interacts differently with membranes mimicking the inner and outer leaflets of neuronal membranes.Biochimica et biophysica acta. Biomembranes, , 02-01, Volume: 1864, Issue:1, 2022
The influence of preconditioning with low dose of LPS on paraquat-induced neurotoxicity, microglia activation and expression of α-synuclein and synphilin-1 in the dopaminergic system.Pharmacological reports : PR, , Volume: 74, Issue:1, 2022
Glycoconjugate journal special issue on: the glycobiology of Parkinson's disease.Glycoconjugate journal, , Volume: 39, Issue:1, 2022
An Update on the Critical Role of α-Synuclein in Parkinson's Disease and Other Synucleinopathies: from Tissue to Cellular and Molecular Levels.Molecular neurobiology, , Volume: 59, Issue:1, 2022
The Compound ATH434 Prevents Alpha-Synuclein Toxicity in a Murine Model of Multiple System Atrophy.Journal of Parkinson's disease, , Volume: 12, Issue:1, 2022
Targeting alpha-synuclein via the immune system in Parkinson's disease: Current vaccine therapies.Neuropharmacology, , 01-01, Volume: 202, 2022
Gut power: Modulation of human amyloid formation by amyloidogenic proteins in the gastrointestinal tract.Current opinion in structural biology, , Volume: 72, 2022
Potential treatment of Parkinson's disease with omega-3 polyunsaturated fatty acids.Nutritional neuroscience, , Volume: 25, Issue:1, 2022
Astrocytic VEGFA: An essential mediator in blood-brain-barrier disruption in Parkinson's disease.Glia, , Volume: 70, Issue:2, 2022
Apomorphine Reduces A53T α-Synuclein-Induced Microglial Reactivity Through Activation of NRF2 Signalling Pathway.Cellular and molecular neurobiology, , Volume: 42, Issue:8, 2022
The epigenetic mechanisms involved in mitochondrial dysfunction: Implication for Parkinson's disease.Brain pathology (Zurich, Switzerland), , Volume: 32, Issue:3, 2022
Ferruginol prevents degeneration of dopaminergic neurons by enhancing clearance of α-synuclein in neuronal cells.Fitoterapia, , Volume: 156, 2022
Imaging protein aggregates in the serum and cerebrospinal fluid in Parkinson's disease.Brain : a journal of neurology, , 04-18, Volume: 145, Issue:2, 2022
Impaired brain insulin signalling in Parkinson's disease.Neuropathology and applied neurobiology, , Volume: 48, Issue:1, 2022
The potential neuroprotective effect of diosmin in rotenone-induced model of Parkinson's disease in rats.European journal of pharmacology, , Jan-05, Volume: 914, 2022
Plasma total tau predicts executive dysfunction in Parkinson's disease.Acta neurologica Scandinavica, , Volume: 145, Issue:1, 2022
Disease-modifying treatment of Parkinson's disease by phytochemicals: targeting multiple pathogenic factors.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 129, Issue:5-6, 2022
Investigating the Roles of Heparan Sulfate Structures in Alpha-Synuclein Aggregation in Cell Culture Models.Methods in molecular biology (Clifton, N.J.), , Volume: 2303, 2022
LGALS3 (galectin 3) mediates an unconventional secretion of SNCA/α-synuclein in response to lysosomal membrane damage by the autophagic-lysosomal pathway in human midbrain dopamine neurons.Autophagy, , Volume: 18, Issue:5, 2022
Associations of sleep disorders with cerebrospinal fluid α-synuclein in prodromal and early Parkinson's disease.Journal of neurology, , Volume: 269, Issue:5, 2022
Neurotoxic or neuroprotective: Post-translational modifications of α-synuclein at the cross-roads of functions.Biochimie, , Volume: 192, 2022
Are Lysosomes Potential Therapeutic Targets for Parkinson's Disease?CNS & neurological disorders drug targets, , Volume: 21, Issue:8, 2022
Brain regions susceptible to alpha-synuclein spreading.Molecular psychiatry, , Volume: 27, Issue:1, 2022
A study on the interaction of the amyloid fibrils of α-synuclein and hen egg white lysozyme with biological membranes.Biochimica et biophysica acta. Biomembranes, , 02-01, Volume: 1864, Issue:1, 2022
Evaluating the role of ARSA in Chinese patients with Parkinson's disease.Neurobiology of aging, , Volume: 109, 2022
Metabolically induced intracellular pH changes activate mitophagy, autophagy, and cell protection in familial forms of Parkinson's disease.The FEBS journal, , Volume: 289, Issue:3, 2022
Targeting α-synuclein aggregation and its role in mitochondrial dysfunction in Parkinson's disease.British journal of pharmacology, , Volume: 179, Issue:1, 2022
α-Synuclein Selectively Impairs Motor Sequence Learning and Value Sensitivity: Reversal by the Adenosine A2A Receptor Antagonists.Cerebral cortex (New York, N.Y. : 1991), , 02-08, Volume: 32, Issue:4, 2022
Innovative treatment targeting gangliosides aimed at blocking the formation of neurotoxic α-synuclein oligomers in Parkinson's disease.Glycoconjugate journal, , Volume: 39, Issue:1, 2022
Neurodegenerative Disorders and the Current State, Pathophysiology, and Management of Parkinson's Disease.CNS & neurological disorders drug targets, , Volume: 21, Issue:7, 2022
MED13 and glycolysis are conserved modifiers of α-synuclein-associated neurodegeneration.Cell reports, , 12-20, Volume: 41, Issue:12, 2022
The safety and effectiveness of α-synuclein immunotherapy vs. placebo for the treatment of Parkinson's disease: a systematic review and meta-analysis.Annals of palliative medicine, , Volume: 11, Issue:12, 2022
Targeting protein clearance pathways in Expert opinion on therapeutic targets, , Volume: 26, Issue:12, 2022
Expansion of regulatory T cells by CD28 superagonistic antibodies attenuates neurodegeneration in A53T-α-synuclein Parkinson's disease mice.Journal of neuroinflammation, , Dec-31, Volume: 19, Issue:1, 2022
Mechanisms of Autoimmune Cell in DA Neuron Apoptosis of Parkinson's Disease: Recent Advancement.Oxidative medicine and cellular longevity, , Volume: 2022, 2022
The Role of Membrane Affinity and Binding Modes in Alpha-Synuclein Regulation of Vesicle Release and Trafficking.Biomolecules, , 12-05, Volume: 12, Issue:12, 2022
Essential collective dynamics analysis reveals nonlocal interactions of alpha-synucleinThe Journal of chemical physics, , Dec-21, Volume: 157, Issue:23, 2022
Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein.Scientific reports, , 12-19, Volume: 12, Issue:1, 2022
Neuronal haemoglobin induces loss of dopaminergic neurons in mouse Substantia nigra, cognitive deficits and cleavage of endogenous α-synuclein.Cell death & disease, , 12-16, Volume: 13, Issue:12, 2022
Granulovacuolar degeneration bodies are independently induced by tau and α-synuclein pathology.Alzheimer's research & therapy, , 12-14, Volume: 14, Issue:1, 2022
A Method to Study α-Synuclein Toxicity and Aggregation Using a Humanized Yeast Model.Journal of visualized experiments : JoVE, , Nov-25, Issue:189, 2022
Early-Onset Parkinson's Disease: Creating the Right Environment for a Genetic Disorder.Journal of Parkinson's disease, , Volume: 12, Issue:8, 2022
Modulation Effects of FeMolecules (Basel, Switzerland), , Dec-01, Volume: 27, Issue:23, 2022
Neuroinflammation and Autophagy in Parkinson's Disease-Novel Perspectives.International journal of molecular sciences, , Nov-30, Volume: 23, Issue:23, 2022
Ligand-Based Discovery of a Small Molecule as Inhibitor of α-Synuclein Amyloid Formation.International journal of molecular sciences, , Nov-27, Volume: 23, Issue:23, 2022
Antibodies against HSV-1 and Curli Show the Highest Correlation in Parkinson's Disease Patients in Comparison to Healthy Controls.International journal of molecular sciences, , Nov-26, Volume: 23, Issue:23, 2022
Pathogenesis of α-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective.International journal of molecular sciences, , Nov-25, Volume: 23, Issue:23, 2022
Structural and Biophysical Characterization of Stable Alpha-Synuclein Oligomers.International journal of molecular sciences, , Nov-23, Volume: 23, Issue:23, 2022
A Single Chain Fragment Variant Binding Misfolded Alpha-Synuclein Exhibits Neuroprotective and Antigen-Specific Anti-Inflammatory Properties.Cells, , Nov-29, Volume: 11, Issue:23, 2022
UBA52 Is Crucial in HSP90 Ubiquitylation and Neurodegenerative Signaling during Early Phase of Parkinson's Disease.Cells, , Nov-25, Volume: 11, Issue:23, 2022
Parkinson's disease drug hunters think outside the α-synuclein box.Nature biotechnology, , Volume: 40, Issue:12, 2022
Axonal degeneration in the anterior insular cortex is associated with Alzheimer's co-pathology in Parkinson's disease and dementia with Lewy bodies.Translational neurodegeneration, , 12-07, Volume: 11, Issue:1, 2022
Observation of α-Synuclein Preformed Fibrils Interacting with SH-SY5Y Neuroblastoma Cell Membranes Using Scanning Ion Conductance Microscopy.ACS chemical neuroscience, , 12-21, Volume: 13, Issue:24, 2022
Patient-derived three-dimensional cortical neurospheres to model Parkinson's disease.PloS one, , Volume: 17, Issue:12, 2022
Correlation between α-synuclein and fatty acid composition in jejunum of rotenone-treated mice is dependent on acyl chain length.General physiology and biophysics, , Volume: 41, Issue:6, 2022
Monoclonal Antibodies in Neurodegenerative Disease May Work, But They Don't Help: A Perspective from Physicians.Journal of Parkinson's disease, , Volume: 12, Issue:8, 2022
Probiotic Frontiers in cellular and infection microbiology, , Volume: 12, 2022
Intronic enhancers of the human Science advances, , 11-25, Volume: 8, Issue:47, 2022
Intracellular Accumulation of α-Synuclein Aggregates Promotes S-Nitrosylation of MAP1A Leading to Decreased NMDAR-Evoked Calcium Influx and Loss of Mature Synaptic Spines.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 12-14, Volume: 42, Issue:50, 2022
Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry Approach to Correlate Local Structure and Aggregation in α-Synuclein.Analytical chemistry, , 12-06, Volume: 94, Issue:48, 2022
This is NOT the End for Immunotherapy in Parkinson's Disease - A Perspective from Early Drug Development Scientists.Journal of Parkinson's disease, , Volume: 12, Issue:8, 2022
Human pericytes degrade diverse α-synuclein aggregates.PloS one, , Volume: 17, Issue:11, 2022
α-Synuclein Disrupts Vesicle Fusion by Two Mutant-Specific Mechanisms.Molecules and cells, , Nov-30, Volume: 45, Issue:11, 2022
Concerted enhanced-sampling simulations to elucidate the helix-fibril transition pathway of intrinsically disordered α-Synuclein.International journal of biological macromolecules, , Dec-31, Volume: 223, Issue:Pt A, 2022
Ubiquitin-positive astrogliopathy clinically mimicking Parkinson's disease.Acta neuropathologica communications, , 11-14, Volume: 10, Issue:1, 2022
Phase separation and other forms of α-Synuclein self-assemblies.Essays in biochemistry, , 12-16, Volume: 66, Issue:7, 2022
Phosphorylated α-Synuclein Deposits in Cutaneous Nerves of Early Parkinsonism.Journal of Parkinson's disease, , Volume: 12, Issue:8, 2022
DOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomers.Nature communications, , 11-12, Volume: 13, Issue:1, 2022
Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders.Acta neuropathologica communications, , 11-12, Volume: 10, Issue:1, 2022
A penetratin-derived peptide reduces the membrane permeabilization and cell toxicity of α-synuclein oligomers.The Journal of biological chemistry, , Volume: 298, Issue:12, 2022
Gastric Enteric Glial Cells: A New Contributor to the Synucleinopathies in the MPTP-Induced Parkinsonism Mouse.Molecules (Basel, Switzerland), , Nov-01, Volume: 27, Issue:21, 2022
AmyP53, a Therapeutic Peptide Candidate for the Treatment of Alzheimer's and Parkinson's Disease: Safety, Stability, Pharmacokinetics Parameters and Nose-to Brain Delivery.International journal of molecular sciences, , Nov-02, Volume: 23, Issue:21, 2022
[no title available]International journal of molecular sciences, , Oct-28, Volume: 23, Issue:21, 2022
Molecular and Cellular Interactions in Pathogenesis of Sporadic Parkinson Disease.International journal of molecular sciences, , Oct-27, Volume: 23, Issue:21, 2022
Glymphatic System Dysfunction and Sleep Disturbance May Contribute to the Pathogenesis and Progression of Parkinson's Disease.International journal of molecular sciences, , Oct-26, Volume: 23, Issue:21, 2022
The 3D structure of lipidic fibrils of α-synuclein.Nature communications, , 11-10, Volume: 13, Issue:1, 2022
Moderate Binding between Two SARS-CoV-2 Protein Segments and α-Synuclein Alters Its Toxic Oligomerization Propensity Differently.The journal of physical chemistry letters, , Nov-17, Volume: 13, Issue:45, 2022
Interactions of dopamine, iron, and alpha-synuclein linked to dopaminergic neuron vulnerability in Parkinson's disease and Neurodegeneration with Brain Iron Accumulation disorders.Neurobiology of disease, , Volume: 175, 2022
Inhibition of α-Synuclein Seeding-Dependent Aggregation by ssDNA Aptamers Specific to C-Terminally Truncated α-Synuclein Fibrils.ACS chemical neuroscience, , 12-07, Volume: 13, Issue:23, 2022
A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice.eLife, , 11-08, Volume: 11, 2022
[Role of fatty acid-binding protein 7 and novel therapeutic approach in synucleinopathies].Nihon yakurigaku zasshi. Folia pharmacologica Japonica, , Volume: 157, Issue:6, 2022
The Glycoprotein GPNMB: A Secret Ingredient for Understanding Parkinson's Disease Etiology?Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:12, 2022
α-Synuclein upregulates bim-mediated apoptosis by negatively regulating endogenous GCN5.Aging, , 10-27, Volume: 14, Issue:20, 2022
SIAH proteins regulate the degradation and intra-mitochondrial aggregation of PINK1: Implications for mitochondrial pathology in Parkinson's disease.Aging cell, , Volume: 21, Issue:12, 2022
Non-Reproducibility of Oral Rotenone as a Model for Parkinson's Disease in Mice.International journal of molecular sciences, , Oct-21, Volume: 23, Issue:20, 2022
Relationship between Substantia Nigra Neuromelanin Imaging and Dual Alpha-Synuclein Labeling of Labial Minor in Salivary Glands in Isolated Rapid Eye Movement Sleep Behavior Disorder and Parkinson's Disease.Genes, , Sep-24, Volume: 13, Issue:10, 2022
Relevance of plasma biomarkers to pathologies in Alzheimer's disease, Parkinson's disease and frontotemporal dementia.Scientific reports, , 10-26, Volume: 12, Issue:1, 2022
Regulation of α-synuclein homeostasis and inflammasome activation by microglial autophagy.Science advances, , 10-28, Volume: 8, Issue:43, 2022
Pharmacological inhibition of AIMP2 aggregation attenuates α-synuclein aggregation and toxicity in Parkinson's disease.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 156, 2022
D-π-A-Based Trisubstituted Alkenes as Environmentally Sensitive Fluorescent Probes to Detect Lewy Pathologies.Analytical chemistry, , 11-08, Volume: 94, Issue:44, 2022
An HPLC-UV validated bioanalytical method for measurement of Xenobiotica; the fate of foreign compounds in biological systems, , Volume: 52, Issue:8, 2022
Human gut microbiota and Parkinson's disease.Progress in molecular biology and translational science, , Volume: 192, Issue:1, 2022
[A role of human microbiota in the development of neurodegenerative diseases].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, , Volume: 122, Issue:10, 2022
A Conceptual Study on the Peripheral Clearance of Brain-Derived α-Synuclein in Humans.Journal of Alzheimer's disease : JAD, , Volume: 90, Issue:4, 2022
Identification of exosomal biomarkers and its optimal isolation and detection method for the diagnosis of Parkinson's disease: A systematic review and meta-analysis.Ageing research reviews, , Volume: 82, 2022
Reelin protects against pathological α-synuclein accumulation and dopaminergic neurodegeneration after environmental enrichment in Parkinson's disease.Neurobiology of disease, , Volume: 175, 2022
Effects of Mutations and Post-Translational Modifications on α-Synuclein In Vitro Aggregation.Journal of molecular biology, , 12-15, Volume: 434, Issue:23, 2022
Identification of Drug-Disease Associations Using a Random Walk with Restart Method and Supervised Learning.Computational and mathematical methods in medicine, , Volume: 2022, 2022
Modeling native and seeded Synuclein aggregation and related cellular dysfunctions in dopaminergic neurons derived by a new set of isogenic iPSC lines with SNCA multiplications.Cell death & disease, , 10-19, Volume: 13, Issue:10, 2022
Intestine-derived α-synuclein initiates and aggravates pathogenesis of Parkinson's disease in Drosophila.Translational neurodegeneration, , 10-17, Volume: 11, Issue:1, 2022
Development of an α-synuclein fibril and oligomer specific tracer for diagnosis of Parkinson's disease, dementia with Lewy bodies and multiple system atrophy.Neurochemistry international, , Volume: 161, 2022
Early α-synuclein aggregation is overall delayed and it can occur by a stepwise mechanism.Biochemical and biophysical research communications, , 12-20, Volume: 635, 2022
Liquid-Liquid Phase Separation Promotes Protein Aggregation and Its Implications in Ferroptosis in Parkinson's Disease Dementia.Oxidative medicine and cellular longevity, , Volume: 2022, 2022
The Potential Role of Voltage-Dependent Anion Channel in the Treatment of Parkinson's Disease.Oxidative medicine and cellular longevity, , Volume: 2022, 2022
Pericytes take up and degrade α-synuclein but succumb to apoptosis under cellular stress.Scientific reports, , 10-15, Volume: 12, Issue:1, 2022
EGCG has Dual and Opposing Effects on the N-terminal Region of Self-associating α-synuclein Oligomers.Journal of molecular biology, , 12-15, Volume: 434, Issue:23, 2022
Saposin C, Key Regulator in the Alpha-Synuclein Degradation Mediated by Lysosome.International journal of molecular sciences, , Oct-09, Volume: 23, Issue:19, 2022
The Potential Roles of Extracellular Vesicles as Biomarkers for Parkinson's Disease: A Systematic Review.International journal of molecular sciences, , Sep-29, Volume: 23, Issue:19, 2022
[Cells, , 09-30, Volume: 11, Issue:19, 2022
Modulatory Role of TPPP3 in Microtubule Organization and Its Impact on Alpha-Synuclein Pathology.Cells, , 09-27, Volume: 11, Issue:19, 2022
ATPase Thorase Deficiency Causes α-Synucleinopathy and Parkinson's Disease-like Behavior.Cells, , 09-26, Volume: 11, Issue:19, 2022
Erythrocytic alpha-synuclein in early Parkinson's disease: A 3-year longitudinal study.Parkinsonism & related disorders, , Volume: 104, 2022
Fucosylated Chondroitin Sulfate against Parkinson's Disease through Inhibiting Inflammation Induced by Gut Dysbiosis.Journal of agricultural and food chemistry, , Oct-26, Volume: 70, Issue:42, 2022
Association between LAG3/CD4 gene variants and risk of Parkinson's disease.European journal of clinical investigation, , Volume: 52, Issue:11, 2022
Global, in situ analysis of the structural proteome in individuals with Parkinson's disease to identify a new class of biomarker.Nature structural & molecular biology, , Volume: 29, Issue:10, 2022
Diagnosis and Treatment of Cognitive and Neuropsychiatric Symptoms in Parkinson Disease and Dementia With Lewy Bodies.Continuum (Minneapolis, Minn.), , Oct-01, Volume: 28, Issue:5, 2022
Development of a Systematic Strategy toward Promotion of α-Synuclein Aggregation Using 2-Hydroxyisophthalamide-Based Systems.Biochemistry, , 11-01, Volume: 61, Issue:21, 2022
Single-cell RNA sequencing of CSF reveals neuroprotective RAC1Frontiers in immunology, , Volume: 13, 2022
Smell deficits in COVID-19 and possible links with Parkinson's disease.International review of neurobiology, , Volume: 165, 2022
Anionic lipid vesicles have differential effects on the aggregation of early onset-associated α-synuclein missense mutants.The Journal of biological chemistry, , Volume: 298, Issue:12, 2022
Aggregation-Seeding Forms of α-Synuclein Are Not Detected in Acute Coronavirus Disease 2019 Cerebrospinal Fluid.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:12, 2022
Quantitative super-resolution imaging of pathological aggregates reveals distinct toxicity profiles in different synucleinopathies.Proceedings of the National Academy of Sciences of the United States of America, , 10-11, Volume: 119, Issue:41, 2022
Microbiota- Brain-Gut-Axis Relevance to Parkinson's Disease: Potential Therapeutic Effects of Probiotics.Current pharmaceutical design, , Volume: 28, Issue:37, 2022
Rapid restructurization of conformationally-distinct alpha-synuclein amyloid fibrils at an elevated temperature.PeerJ, , Volume: 10, 2022
Is there a halo-enzymopathy in Parkinson's disease?Neurologia, , Volume: 37, Issue:8, 2022
A Combined α-Synuclein/Fibril (SynFib) Model of Parkinson-Like Synucleinopathy Targeting the Nigrostriatal Dopamine System.Journal of Parkinson's disease, , Volume: 12, Issue:8, 2022
Progress in Parkinson's disease animal models of genetic defects: Characteristics and application.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 155, 2022
Quaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein.Communications biology, , 09-30, Volume: 5, Issue:1, 2022
High-content phenotyping of Parkinson's disease patient stem cell-derived midbrain dopaminergic neurons using machine learning classification.Stem cell reports, , 10-11, Volume: 17, Issue:10, 2022
AMPK-dependent autophagy activation and alpha-Synuclein clearance: a putative mechanism behind alpha-mangostin's neuroprotection in a rotenone-induced mouse model of Parkinson's disease.Metabolic brain disease, , Volume: 37, Issue:8, 2022
Regulation of Parkinson's disease-associated genes by Pumilio proteins and microRNAs in SH-SY5Y neuronal cells.PloS one, , Volume: 17, Issue:9, 2022
Retrograde Axonal Autophagy and Endocytic Pathways Are Parallel and Separate in Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 11-09, Volume: 42, Issue:45, 2022
6-Hydroxydopamine-Induced Neurotoxicity in Rat Model of Parkinson's Disease: Is Reversed via Anti-Oxidative Activities of Curcumin and Aerobic Exercise Therapy.Physiological research, , Aug-31, Volume: 71, Issue:4, 2022
Thoracic trauma promotes alpha-Synuclein oligomerization in murine Parkinson's disease.Neurobiology of disease, , Volume: 174, 2022
Early Dysbiosis and Dampened Gut Microbe Oscillation Precede Motor Dysfunction and Neuropathology in Animal Models of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:8, 2022
First trials test targeting of α-synuclein for Parkinson disease.Nature reviews. Neurology, , Volume: 18, Issue:12, 2022
α-Syn overexpression, NRF2 suppression, and enhanced ferroptosis create a vicious cycle of neuronal loss in Parkinson's disease.Free radical biology & medicine, , 11-01, Volume: 192, 2022
Age-related pathological impairments in directly reprogrammed dopaminergic neurons derived from patients with idiopathic Parkinson's disease.Stem cell reports, , 10-11, Volume: 17, Issue:10, 2022
Pattern of Mitochondrial Respiration in Peripheral Blood Cells of Patients with Parkinson's Disease.International journal of molecular sciences, , Sep-17, Volume: 23, Issue:18, 2022
Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson's Disease.International journal of molecular sciences, , Sep-16, Volume: 23, Issue:18, 2022
The Effect of Aggregated Alpha Synuclein on Synaptic and Axonal Proteins in Parkinson's Disease-A Systematic Review.Biomolecules, , 08-29, Volume: 12, Issue:9, 2022
Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia.Cell reports, , 09-20, Volume: 40, Issue:12, 2022
Small soluble α-synuclein aggregates are the toxic species in Parkinson's disease.Nature communications, , 09-20, Volume: 13, Issue:1, 2022
Direct Observation of "Elongated" Conformational States in α-Synuclein upon Liquid-Liquid Phase Separation.Angewandte Chemie (International ed. in English), , 11-14, Volume: 61, Issue:46, 2022
Idiopathic rapid eye movement sleep behavior disorder in Japan: An observational study.Parkinsonism & related disorders, , Volume: 103, 2022
Propagation of Parkinson's disease by extracellular vesicle production and secretion.Biochemical Society transactions, , 10-31, Volume: 50, Issue:5, 2022
Neuroprotective effects of cannabidiol on dopaminergic neurodegeneration and α-synuclein accumulation in C. elegans models of Parkinson's disease.Neurotoxicology, , Volume: 93, 2022
Structures of α-synuclein filaments from human brains with Lewy pathology.Nature, , Volume: 610, Issue:7933, 2022
Paraquat exposure induces Parkinsonism by altering lipid profile and evoking neuroinflammation in the midbrain.Environment international, , Volume: 169, 2022
Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases.BioEssays : news and reviews in molecular, cellular and developmental biology, , Volume: 44, Issue:11, 2022
Involvement of heat shock proteins and parkin/α-synuclein axis in Parkinson's disease.Molecular biology reports, , Volume: 49, Issue:11, 2022
Disease-Associated α-Synuclein Aggregates as Biomarkers of Parkinson Disease Clinical Stage.Neurology, , 11-22, Volume: 99, Issue:21, 2022
Fenofibrate promotes neuroprotection in a model of rotenone-induced Parkinson's disease.Behavioural pharmacology, , 12-01, Volume: 33, Issue:8, 2022
Exploring the Paradox of COVID-19 in Neurological Complications with Emphasis on Parkinson's and Alzheimer's Disease.Oxidative medicine and cellular longevity, , Volume: 2022, 2022
Hemoglobin-binding α-synuclein levels in erythrocytes are elevated in patients with multiple system atrophy.Neuroscience letters, , 10-15, Volume: 789, 2022
Exposure to the environmentally toxic pesticide maneb induces Parkinson's disease-like neurotoxicity in mice: A combined proteomic and metabolomic analysis.Chemosphere, , Volume: 308, Issue:Pt 2, 2022
Detection of α-Synuclein-Specific T Cells in Parkinson's Disease.Methods in molecular biology (Clifton, N.J.), , Volume: 2574, 2022
Homozygous CADPS2 Mutations Cause Neurodegenerative Disease with Lewy Body-like Pathology in Parrots.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:12, 2022
Transmembrane protein interacts with α-synuclein to confer risk of PD.Nature reviews. Neurology, , Volume: 18, Issue:10, 2022
Alpha-synuclein Immunization Strategies for Synucleinopathies in Clinical Studies: A Biological Perspective.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 19, Issue:5, 2022
The Intranigral Infusion of Human-Alpha Synuclein Oligomers Induces a Cognitive Impairment in Rats Associated with Changes in Neuronal Firing and Neuroinflammation in the Anterior Cingulate Cortex.Cells, , 08-24, Volume: 11, Issue:17, 2022
Neuropathology of the Basal Ganglia in SNCA Transgenic Rat Model of Parkinson's Disease: Involvement of Parvalbuminergic Interneurons and Glial-Derived Neurotropic Factor.International journal of molecular sciences, , Sep-04, Volume: 23, Issue:17, 2022
Alpha-Synuclein: The Spark That Flames Dopaminergic Neurons, In Vitro and In Vivo Evidence.International journal of molecular sciences, , Aug-30, Volume: 23, Issue:17, 2022
Post-COVID-19 Parkinsonism and Parkinson's Disease Pathogenesis: The Exosomal Cargo Hypothesis.International journal of molecular sciences, , Aug-28, Volume: 23, Issue:17, 2022
Mitochondrial dysfunction is a key pathological driver of early stage Parkinson's.Acta neuropathologica communications, , 09-08, Volume: 10, Issue:1, 2022
Discrepancy between distribution of alpha-synuclein oligomers and Lewy-related pathology in Parkinson's disease.Acta neuropathologica communications, , 09-06, Volume: 10, Issue:1, 2022
Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD.Molecular neurodegeneration, , 09-05, Volume: 17, Issue:1, 2022
Inhibition of α-synuclein aggregation by MT101-5 is neuroprotective in mouse models of Parkinson's disease.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 154, 2022
LRP1 is a neuronal receptor for α-synuclein uptake and spread.Molecular neurodegeneration, , 09-02, Volume: 17, Issue:1, 2022
Nanozyme-based cascade SPR signal amplification for immunosensing of nitrated alpha-synuclein.Mikrochimica acta, , 09-02, Volume: 189, Issue:10, 2022
Fine Particulate Matter Triggers α-Synuclein Fibrillization and Parkinson-like Neurodegeneration.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:9, 2022
Exploring Structural Flexibility and Stability of α-Synuclein by the Landau-Ginzburg-Wilson Approach.The journal of physical chemistry. B, , 09-15, Volume: 126, Issue:36, 2022
Adaptive structural changes in the motor cortex and white matter in Parkinson's disease.Acta neuropathologica, , Volume: 144, Issue:5, 2022
Ghrelin Bridges DMV Neuropathology and GI Dysfunction in the Early Stages of Parkinson's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany), , Volume: 9, Issue:30, 2022
Chlorogenic Acid: a Polyphenol from Coffee Rendered Neuroprotection Against Rotenone-Induced Parkinson's Disease by GLP-1 Secretion.Molecular neurobiology, , Volume: 59, Issue:11, 2022
Different patterns of exosomal α-synuclein between Parkinson's disease and probable rapid eye movement sleep behavior disorder.European journal of neurology, , Volume: 29, Issue:12, 2022
Neuronal hyperactivity-induced oxidant stress promotes in vivo α-synuclein brain spreading.Science advances, , 09-02, Volume: 8, Issue:35, 2022
Amelioration of pathologic α-synuclein-induced Parkinson's disease by irisin.Proceedings of the National Academy of Sciences of the United States of America, , 09-06, Volume: 119, Issue:36, 2022
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity.Nature neuroscience, , Volume: 25, Issue:9, 2022
Type 2 diabetes mellitus augments Parkinson's disease risk or the other way around: Facts, challenges and future possibilities.Ageing research reviews, , Volume: 81, 2022
Neuroinflammation in Parkinson's Disease and its Treatment Opportunities.Balkan medical journal, , 09-09, Volume: 39, Issue:5, 2022
In vivo and autopsy validation of alpha-synuclein seeding activity using RT-QuIC assay in the gastrointestinal tract of patients with Parkinson's disease.Parkinsonism & related disorders, , Volume: 103, 2022
Post-translational Modifications in Parkinson's Disease.Advances in experimental medicine and biology, , Volume: 1382, 2022
Family History for Neurodegeneration in Multiple System Atrophy: Does it Indicate Susceptibility?Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:11, 2022
Physiological and Pathological Functions of Neuronal Hemoglobin: A Key Underappreciated Protein in Parkinson's Disease.International journal of molecular sciences, , Aug-13, Volume: 23, Issue:16, 2022
Translocation of Distinct Alpha Synuclein Species from the Nucleus to Neuronal Processes during Neuronal Differentiation.Biomolecules, , 08-12, Volume: 12, Issue:8, 2022
Single residue modulators of amyloid formation in the N-terminal P1-region of α-synuclein.Nature communications, , 08-25, Volume: 13, Issue:1, 2022
Examination of Abnormal Alpha-synuclein Aggregates in the Enteric Neural Plexus in Patients with Ulcerative Colitis.Journal of gastrointestinal and liver diseases : JGLD, , 09-15, Volume: 31, Issue:3, 2022
Alpha synuclein determines ferroptosis sensitivity in dopaminergic neurons via modulation of ether-phospholipid membrane composition.Cell reports, , 08-23, Volume: 40, Issue:8, 2022
Untwisted α-Synuclein Filaments Formed in the Presence of Lipid Vesicles.Biochemistry, , 09-06, Volume: 61, Issue:17, 2022
Skeletal Muscle is a Source of α-Synuclein with a Sarcolemmal Non-Lipid Raft Distribution.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , Aug-25, Volume: 56, Issue:4, 2022
Threonine Cavities Are Targetable Motifs That Control Alpha-Synuclein Fibril Growth.ACS chemical neuroscience, , 09-07, Volume: 13, Issue:17, 2022
Multiple checkpoints of protein clearance machinery are modulated by a common microRNA, miR-4813-3p, through its putative target genes: Studies employing transgenic C. elegans model.Biochimica et biophysica acta. Molecular cell research, , Volume: 1869, Issue:12, 2022
JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species.Neurotoxicity research, , Volume: 40, Issue:6, 2022
Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology.Nature communications, , 08-22, Volume: 13, Issue:1, 2022
Lewy Body Disease Primate Model with α-Synuclein Propagation from the Olfactory Bulb.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:10, 2022
Role of NLRP3 Inflammasome in Parkinson's Disease and Therapeutic Considerations.Journal of Parkinson's disease, , Volume: 12, Issue:7, 2022
Identification of a biological excimer involving protein-protein interactions: A case study of the α-synuclein aggregation.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, , Dec-15, Volume: 283, 2022
Natural speech markers of Alzheimer's disease co-pathology in Lewy body dementias.Parkinsonism & related disorders, , Volume: 102, 2022
Systemic RNA Interference Defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans.PLoS genetics, , Volume: 18, Issue:8, 2022
Baicalein exhibits differential effects and mechanisms towards disruption of α-synuclein fibrils with different polymorphs.International journal of biological macromolecules, , Nov-01, Volume: 220, 2022
GPNMB confers risk for Parkinson's disease through interaction with α-synuclein.Science (New York, N.Y.), , 08-19, Volume: 377, Issue:6608, 2022
Reply to: "Could Blood Hexosylsphingosine Be a Marker for Parkinson's Disease Linked with GBA1 Mutations"?Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:8, 2022
Reply to: "Overlapping Ranges in Levels Indicate That Hexosylsphingosine Is Not a Clinically Relevant Biomarker for GBA1-Associated Parkinson's Disease".Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:8, 2022
De novo designed protein inhibitors of amyloid aggregation and seeding.Proceedings of the National Academy of Sciences of the United States of America, , 08-23, Volume: 119, Issue:34, 2022
Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein.Journal of visualized experiments : JoVE, , 07-29, Issue:185, 2022
A task-specific cognitive domain decline is correlated with plasma and neuroimaging markers in patients with Parkinson's disease.Journal of neurology, , Volume: 269, Issue:12, 2022
Removal of proteinase K resistant αSyn species does not correlate with cell survival in a virus vector-based Parkinson's disease mouse model.Neuropharmacology, , 11-01, Volume: 218, 2022
Constipation distinguishes different clinical-biochemical patterns in de novo Parkinson's disease.Parkinsonism & related disorders, , Volume: 102, 2022
Modulation of Inflammatory Mediators and Microglial Activation Through Physical Exercise in Alzheimer's and Parkinson's Diseases.Neurochemical research, , Volume: 47, Issue:11, 2022
Measurement of α-Synuclein Dynamics In Vivo Using Microdialysis with a Novel Homogeneous Immunoassay.ACS chemical neuroscience, , 09-07, Volume: 13, Issue:17, 2022
Phase 1/1b Studies of UCB0599, an Oral Inhibitor of α-Synuclein Misfolding, Including a Randomized Study in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:10, 2022
Synthetic Peucedanocoumarin IV Prevents α-Synuclein Neurotoxicity in an Animal Model of Parkinson's Disease.International journal of molecular sciences, , Aug-03, Volume: 23, Issue:15, 2022
Increased Expression of Alpha-, Beta-, and Gamma-Synucleins in Brainstem Regions of a Non-Human Primate Model of Parkinson's Disease.International journal of molecular sciences, , Aug-02, Volume: 23, Issue:15, 2022
Neuronal ApoE Regulates the Cell-to-Cell Transmission of α-Synuclein.International journal of molecular sciences, , Jul-27, Volume: 23, Issue:15, 2022
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Alteration of Vesicle-Associated Membrane Protein-Binding Protein B in α-Synuclein Aggregates in Lewy Body Disease.Journal of neuropathology and experimental neurology, , 09-19, Volume: 81, Issue:10, 2022
Characterizing Lewy Pathology in 231 Essential Tremor Brains From the Essential Tremor Centralized Brain Repository.Journal of neuropathology and experimental neurology, , 09-19, Volume: 81, Issue:10, 2022
C-terminal truncation modulates α-Synuclein's cytotoxicity and aggregation by promoting the interactions with membrane and chaperone.Communications biology, , 08-09, Volume: 5, Issue:1, 2022
Extracellular vesicles and seeding amplification: a step closer to a Parkinson's disease blood test.Brain : a journal of neurology, , 09-14, Volume: 145, Issue:9, 2022
Gray Matter Volume Loss in Proposed Brain-First and Body-First Parkinson's Disease Subtypes.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:10, 2022
[Ascendance of Abnormal α-synuclein Fibrils Through the Vagal Nerve in Parkinson's Disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 74, Issue:8, 2022
Synaptic Neurofilaments and GluN1-Neurofilament Light Chain Interaction in Experimental Models of α-Synucleinopathies.Neuro-degenerative diseases, , Volume: 22, Issue:1, 2022
B Lymphocytes in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
Glucocerebrosidase mutations and Parkinson disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 129, Issue:9, 2022
Designer D-peptides targeting the N-terminal region of α-synuclein to prevent parkinsonian-associated fibrilization and cytotoxicity.Biochimica et biophysica acta. Proteins and proteomics, , 10-01, Volume: 1870, Issue:10, 2022
4-Phenylbutyrate Mitigates the Motor Impairment and Dopaminergic Neuronal Death During Parkinson's Disease Pathology via Targeting VDAC1 Mediated Mitochondrial Function and Astrocytes Activation.Neurochemical research, , Volume: 47, Issue:11, 2022
Involvement of autophagic protein DEF8 in Lewy bodies.Biochemical and biophysical research communications, , 10-01, Volume: 623, 2022
Trial of Prasinezumab in Early-Stage Parkinson's Disease.The New England journal of medicine, , 08-04, Volume: 387, Issue:5, 2022
Trial of Cinpanemab in Early Parkinson's Disease.The New England journal of medicine, , 08-04, Volume: 387, Issue:5, 2022
Rabphilin-3A as a novel target to reverse α-synuclein-induced synaptic loss in Parkinson's disease.Pharmacological research, , Volume: 183, 2022
Polygenic risk prediction and SNCA haplotype analysis in a Latino Parkinson's disease cohort.Parkinsonism & related disorders, , Volume: 102, 2022
The Zinc Ionophore Clioquinol Reduces Parkinson's Disease Patient-Derived Brain Extracts-Induced Neurodegeneration.Molecular neurobiology, , Volume: 59, Issue:10, 2022
α-Synuclein Seed Amplification Assays for Diagnosing Synucleinopathies: The Way Forward.Neurology, , 08-02, Volume: 99, Issue:5, 2022
Dual Effects: Intrastriatal Injection of α-syn N103/tau N368 Preformed Fibrils Promotes Endogenous α-synuclein Aggregates in the Proximal Colon.Journal of Parkinson's disease, , Volume: 12, Issue:7, 2022
Pathological substrate of memory impairment in multiple system atrophy.Neuropathology and applied neurobiology, , Volume: 48, Issue:7, 2022
Functional Cooperation of α-Synuclein and Tau Is Essential for Proper Corticogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 09-14, Volume: 42, Issue:37, 2022
Is peripheral alpha synuclein a marker for gait velocity in Parkinson's disease?Neuroscience letters, , 08-24, Volume: 786, 2022
Modeling the dynamics of innate immune response to Parkinson disease with therapeutic approach.Physical biology, , 08-18, Volume: 19, Issue:5, 2022
NXP031 prevents dopaminergic neuronal loss and oxidative damage in the AAV-WT-α-synuclein mouse model of Parkinson's disease.PloS one, , Volume: 17, Issue:7, 2022
Influence of heavy metals in Parkinson's disease: an overview.Journal of neurology, , Volume: 269, Issue:11, 2022
Inhibition of Ubiquitin-Specific Protease-13 Improves Behavioral Performance in Alpha-Synuclein Expressing Mice.International journal of molecular sciences, , Jul-23, Volume: 23, Issue:15, 2022
Parkinson's Disease Etiology: Insights and Associations with Phosphate Toxicity.International journal of molecular sciences, , Jul-22, Volume: 23, Issue:15, 2022
Recent advances in establishing fluid biomarkers for the diagnosis and differentiation of alpha-synucleinopathies - a mini review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 32, Issue:4, 2022
Exogenous Tetranectin Alleviates Pre-formed-fibrils-induced Synucleinopathies in SH-SY5Y Cells by Activating the Plasminogen Activation System.Neurochemical research, , Volume: 47, Issue:10, 2022
Dysregulation of peripheral monocytes and pro-inflammation of alpha-synuclein in Parkinson's disease.Journal of neurology, , Volume: 269, Issue:12, 2022
α-Synuclein V15A Variant in Familial Parkinson's Disease Exhibits a Weaker Lipid-Binding Property.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:10, 2022
α-Synuclein Conformational Plasticity: Physiologic States, Pathologic Strains, and Biotechnological Applications.Biomolecules, , 07-17, Volume: 12, Issue:7, 2022
Exosomes in Alpha-Synucleinopathies: Propagators of Pathology or Potential Candidates for Nanotherapeutics?Biomolecules, , 07-08, Volume: 12, Issue:7, 2022
Early Signs of Molecular Defects in iPSC-Derived Neural Stems Cells from Patients with Familial Parkinson's Disease.Biomolecules, , 06-23, Volume: 12, Issue:7, 2022
Association of Cerebrospinal Fluid Neurofilament Heavy Protein Levels With Clinical Progression in Patients With Parkinson Disease.JAMA network open, , 07-01, Volume: 5, Issue:7, 2022
Therapeutic Strategies for Immune Transformation in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
A FRET-based aptasensor for the detection of α-synuclein oligomers as biomarkers of Parkinson's disease.Analytical methods : advancing methods and applications, , 08-04, Volume: 14, Issue:30, 2022
Rapid macropinocytic transfer of α-synuclein to lysosomes.Cell reports, , 07-19, Volume: 40, Issue:3, 2022
Targets for astrocyte-based treatments of Parkinson's disease (PD).Proceedings of the National Academy of Sciences of the United States of America, , 07-26, Volume: 119, Issue:30, 2022
Therapeutic functions of astrocytes to treat α-synuclein pathology in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 07-19, Volume: 119, Issue:29, 2022
A versatile fluorescence-quenched substrate for quantitative measurement of glucocerebrosidase activity within live cells.Proceedings of the National Academy of Sciences of the United States of America, , 07-19, Volume: 119, Issue:29, 2022
Deciphering Intertwined Molecular Pathways Underlying Metabolic Syndrome Leading to Parkinson's Disease.ACS chemical neuroscience, , 08-03, Volume: 13, Issue:15, 2022
α-Synuclein fibril-specific nanobody reduces prion-like α-synuclein spreading in mice.Nature communications, , 07-19, Volume: 13, Issue:1, 2022
α-Synuclein PET and Parkinson Disease Therapeutic Trials: Ever the Twain Shall Meet?Journal of nuclear medicine : official publication, Society of Nuclear Medicine, , Volume: 63, Issue:10, 2022
Inflammasome Activation in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
MANF Inhibits Oxidative medicine and cellular longevity, , Volume: 2022, 2022
Absence of Gem1 (mammalian Miro/Rhot) mitigates alpha-synuclein toxicity in a yeast model of Parkinson's disease.Molecular and cellular neurosciences, , Volume: 122, 2022
A small molecule toll-like receptor antagonist rescues α-synuclein fibril pathology.The Journal of biological chemistry, , Volume: 298, Issue:8, 2022
17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson's disease are associated with LRRC37A/2 expression in astrocytes.Molecular neurodegeneration, , 07-15, Volume: 17, Issue:1, 2022
Optimizing Epitope Conformational Ensembles Using α-Synuclein Cyclic Peptide "Glycindel" Scaffolds: A Customized Immunogen Method for Generating Oligomer-Selective Antibodies for Parkinson's Disease.ACS chemical neuroscience, , 08-03, Volume: 13, Issue:15, 2022
Diagnostic and therapeutic agents that target alpha-synuclein in Parkinson's disease.Journal of neurology, , Volume: 269, Issue:11, 2022
Bivalent metal ions induce formation of α-synuclein fibril polymorphs with different cytotoxicities.Scientific reports, , 07-13, Volume: 12, Issue:1, 2022
Identifying the best biomarkers for α-synucleinopathies.The Lancet. Neurology, , Volume: 20, Issue:8, 2021
Parkinson's Disease-Related Genes and Lipid Alteration.International journal of molecular sciences, , Jul-16, Volume: 22, Issue:14, 2021
Further Characterization of Intrastriatal Lipopolysaccharide Model of Parkinson's Disease in C57BL/6 Mice.International journal of molecular sciences, , Jul-09, Volume: 22, Issue:14, 2021
Dopamine-dependent early synaptic and motor dysfunctions induced by α-synuclein in the nigrostriatal circuit.Brain : a journal of neurology, , 12-16, Volume: 144, Issue:11, 2021
Mechanistic roles for altered O-GlcNAcylation in neurodegenerative disorders.The Biochemical journal, , 07-30, Volume: 478, Issue:14, 2021
Iron reduces the propagation of pathological α-synuclein: An Editorial Highlight for "Brain iron enrichment attenuates α-synuclein spreading after injection of preformed fibrils" on page 554.Journal of neurochemistry, , Volume: 159, Issue:3, 2021
Visualization of early oligomeric α-synuclein pathology and its impact on the dopaminergic system in the (Thy-1)-h[A30P]α-syn transgenic mouse model.Journal of neuroscience research, , Volume: 99, Issue:10, 2021
Clustered regularly interspaced short palindromic repeats as an advanced treatment for Parkinson's disease.Brain and behavior, , Volume: 11, Issue:8, 2021
Temporal trajectory of biofluid markers in Parkinson's disease.Scientific reports, , 07-20, Volume: 11, Issue:1, 2021
Trojan horses and tunneling nanotubes enable α-synuclein pathology to spread in Parkinson disease.PLoS biology, , Volume: 19, Issue:7, 2021
Lewy bodies in the olfactory system and the hypothalamus.Handbook of clinical neurology, , Volume: 182, 2021
Hypothalamic α-synuclein and its relation to autonomic symptoms and neuroendocrine abnormalities in Parkinson disease.Handbook of clinical neurology, , Volume: 182, 2021
Effects of head trauma and sport participation in young-onset Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 128, Issue:8, 2021
Electrochemical flow injection analysis of the interaction between pyrroloquinoline quinone (PQQ) and α-synuclein peptides related to Parkinson's disease.The Analyst, , Jul-21, Volume: 146, Issue:14, 2021
Cutaneous α-synuclein is correlated with autonomic impairment in isolated rapid eye movement sleep behavior disorder.Sleep, , 12-10, Volume: 44, Issue:12, 2021
Macromolecular crowding modulates α-synuclein amyloid fiber growth.Biophysical journal, , 08-17, Volume: 120, Issue:16, 2021
Parkinson's Disease Genetics and Pathophysiology.Annual review of neuroscience, , 07-08, Volume: 44, 2021
miR-101-3p Contributes to Journal of healthcare engineering, , Volume: 2021, 2021
PIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia.Molecular psychiatry, , Volume: 26, Issue:10, 2021
Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson's disease.Cell reports, , 07-06, Volume: 36, Issue:1, 2021
A new alpha-synuclein missense variant (Thr72Met) in two Turkish families with Parkinson's disease.Parkinsonism & related disorders, , Volume: 89, 2021
Intracranial administration of alpha-synuclein fibrils in A30P-synuclein transgenic mice causes robust synucleinopathy and microglial induction.Neurobiology of aging, , Volume: 106, 2021
Saffron ameliorated motor symptoms, short life span and retinal degeneration in Parkinson's disease fly models.Gene, , Oct-05, Volume: 799, 2021
Acupuncture for Parkinson's Disease: Efficacy Evaluation and Mechanisms in the Dopaminergic Neural Circuit.Neural plasticity, , Volume: 2021, 2021
Preformed fibrils generated from mouse alpha-synuclein produce more inclusion pathology in rats than fibrils generated from rat alpha-synuclein.Parkinsonism & related disorders, , Volume: 89, 2021
Common and rare variants in HFE are not associated with Parkinson's disease in Europeans.Neurobiology of aging, , Volume: 107, 2021
Glucosylceramide Associated with Gaucher Disease Forms Amyloid-like Twisted Ribbon Fibrils That Induce α-Synuclein Aggregation.ACS nano, , Jul-27, Volume: 15, Issue:7, 2021
Inhibition of Ceramide Synthesis Reduces α-Synuclein Proteinopathy in a Cellular Model of Parkinson's Disease.International journal of molecular sciences, , Jun-16, Volume: 22, Issue:12, 2021
Recent Insights into the Interplay of Alpha-Synuclein and Sphingolipid Signaling in Parkinson's Disease.International journal of molecular sciences, , Jun-11, Volume: 22, Issue:12, 2021
The Catecholaldehyde Hypothesis for the Pathogenesis of Catecholaminergic Neurodegeneration: What We Know and What We Do Not Know.International journal of molecular sciences, , Jun-01, Volume: 22, Issue:11, 2021
Administration of AAV-Alpha Synuclein NAC Antibody Improves Locomotor Behavior in Rats Overexpressing Alpha Synuclein.Genes, , 06-21, Volume: 12, Issue:6, 2021
Natural Alkaloid Compounds as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity.Molecules (Basel, Switzerland), , Jun-19, Volume: 26, Issue:12, 2021
Alpha-Synuclein as a Prominent Actor in the Inflammatory Synaptopathy of Parkinson's Disease.International journal of molecular sciences, , Jun-17, Volume: 22, Issue:12, 2021
Small Molecule Fisetin Modulates Alpha-Synuclein Aggregation.Molecules (Basel, Switzerland), , Jun-02, Volume: 26, Issue:11, 2021
Structural Features and Toxicity of α-Synuclein Oligomers Grown in the Presence of DOPAC.International journal of molecular sciences, , Jun-02, Volume: 22, Issue:11, 2021
Neuroprotective Effects of Trehalose and Sodium Butyrate on Preformed Fibrillar Form of α-Synuclein-Induced Rat Model of Parkinson's Disease.ACS chemical neuroscience, , 07-21, Volume: 12, Issue:14, 2021
[The novel mechanism of α-synuclein propagation in synucleinopathy].Nihon yakurigaku zasshi. Folia pharmacologica Japonica, , Volume: 156, Issue:4, 2021
Investigation of α-Synuclein Species in Plasma Exosomes and the Oligomeric and Phosphorylated α-Synuclein as Potential Peripheral Biomarker of Parkinson's Disease.Neuroscience, , 08-10, Volume: 469, 2021
CSF Protein Level of Neurotransmitter Secretion, Synaptic Plasticity, and Autophagy in PD and DLB.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:11, 2021
C-terminal truncation of α-synuclein alters DNA structure from extension to compaction.Biochemical and biophysical research communications, , 09-03, Volume: 568, 2021
Mini review - The role of Glucocerebrosidase and Progranulin as possible targets in the treatment of Parkinson's disease.Revue neurologique, , Volume: 177, Issue:9, 2021
Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 06-29, Volume: 118, Issue:26, 2021
Remodeling of the Fibrillation Pathway of α-Synuclein by Interaction with Antimicrobial Peptide LL-III.Chemistry (Weinheim an der Bergstrasse, Germany), , Aug-16, Volume: 27, Issue:46, 2021
Physicochemical characterization of the G51D mutation of α-synuclein that is responsible for its severe cytotoxicity.Neuroscience letters, , 08-24, Volume: 760, 2021
Phenotypic manifestation of α-synuclein strains derived from Parkinson's disease and multiple system atrophy in human dopaminergic neurons.Nature communications, , 06-21, Volume: 12, Issue:1, 2021
An Emerging Role for Phosphoinositides in the Pathophysiology of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 11, Issue:4, 2021
Vagus Nerve and Stomach Synucleinopathy in Parkinson's Disease, Incidental Lewy Body Disease, and Normal Elderly Subjects: Evidence Against the "Body-First" Hypothesis.Journal of Parkinson's disease, , Volume: 11, Issue:4, 2021
Comparison of Different Platform Immunoassays for the Measurement of Plasma Alpha-Synuclein in Parkinson's Disease Patients.Journal of Parkinson's disease, , Volume: 11, Issue:4, 2021
α-Synuclein Responses in the Laterodorsal Tegmentum, the Pedunculopontine Tegmentum, and the Substantia Nigra: Implications for Early Appearance of Sleep Disorders in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 11, Issue:4, 2021
Human amyloid beta and α-synuclein co-expression in neurons impair behavior and recapitulate features for Lewy body dementia in Caenorhabditis elegans.Biochimica et biophysica acta. Molecular basis of disease, , 10-01, Volume: 1867, Issue:10, 2021
α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity.Nature communications, , 06-18, Volume: 12, Issue:1, 2021
Intranasal Carnosine Mitigates α-Synuclein Pathology and Motor Dysfunction in the Thy1-aSyn Mouse Model of Parkinson's Disease.ACS chemical neuroscience, , 07-07, Volume: 12, Issue:13, 2021
LMK235, a small molecule inhibitor of HDAC4/5, protects dopaminergic neurons against neurotoxin- and α-synuclein-induced degeneration in cellular models of Parkinson's disease.Molecular and cellular neurosciences, , Volume: 115, 2021
From Kuru to Alzheimer: A personal outlook.Protein science : a publication of the Protein Society, , Volume: 30, Issue:9, 2021
The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson's disease brain as revealed by multicolor STED microscopy.Acta neuropathologica, , Volume: 142, Issue:3, 2021
Can Plasma α-Synuclein Help Us to Differentiate Parkinson's Disease from Essential Tremor?Tremor and other hyperkinetic movements (New York, N.Y.), , 05-28, Volume: 11, 2021
Intranasal infusion of GD3 and GM1 gangliosides downregulates alpha-synuclein and controls tyrosine hydroxylase gene in a PD model mouse.Molecular therapy : the journal of the American Society of Gene Therapy, , 10-06, Volume: 29, Issue:10, 2021
Domain-Independent Inhibition of CBP/p300 Attenuates α-Synuclein Aggregation.ACS chemical neuroscience, , 07-07, Volume: 12, Issue:13, 2021
An attempt to dissect a peripheral marker based on cell pathology in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 128, Issue:10, 2021
In Parkinson's patient-derived dopamine neurons, the triplication of α-synuclein locus induces distinctive firing pattern by impeding D2 receptor autoinhibition.Acta neuropathologica communications, , 06-07, Volume: 9, Issue:1, 2021
Gut and brain profiles that resemble pre-motor and early-stage Parkinson's disease in methamphetamine self-administering rats.Drug and alcohol dependence, , 08-01, Volume: 225, 2021
Potentials of autophagy enhancing natural products in the treatment of Parkinson disease.Drug metabolism and personalized therapy, , 08-13, Volume: 37, Issue:2, 2021
Activated microglia facilitate the transmission of α-synuclein in Parkinson's disease.Neurochemistry international, , Volume: 148, 2021
Gene Therapy to Modulate Alpha-Synuclein in Synucleinopathies.Journal of Parkinson's disease, , Volume: 11, Issue:s2, 2021
Safety and Tolerability of Active Immunotherapy Targeting α-Synuclein with PD03A in Patients with Early Parkinson's Disease: A Randomized, Placebo-Controlled, Phase 1 Study.Journal of Parkinson's disease, , Volume: 11, Issue:3, 2021
The Human Hippocampus in Parkinson's Disease: An Integrative Stereological and Proteomic Study.Journal of Parkinson's disease, , Volume: 11, Issue:3, 2021
α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response.Acta neuropathologica communications, , 06-06, Volume: 9, Issue:1, 2021
Biomarkers for neurodegenerative diseases.Nature medicine, , Volume: 27, Issue:6, 2021
Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates.Journal of neuroinflammation, , Jun-03, Volume: 18, Issue:1, 2021
α-Synuclein Deposition in Sympathetic Nerve Fibers in Genetic Forms of Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:10, 2021
Identification of amyloidogenic proteins in the microbiomes of a rat Parkinson's disease model and wild-type rats.Protein science : a publication of the Protein Society, , Volume: 30, Issue:9, 2021
RT-QuIC Using C-Terminally Truncated α-Synuclein Forms Detects Differences in Seeding Propensity of Different Brain Regions from Synucleinopathies.Biomolecules, , 05-31, Volume: 11, Issue:6, 2021
Plasma Extracellular Vesicle α-Synuclein Level in Patients with Parkinson's Disease.Biomolecules, , 05-17, Volume: 11, Issue:5, 2021
Green Tea Epigallocatechin-3-gallate (EGCG) Targeting Protein Misfolding in Drug Discovery for Neurodegenerative Diseases.Biomolecules, , 05-20, Volume: 11, Issue:5, 2021
α-Synuclein A53T Binds to Transcriptional Adapter 2-Alpha and Blocks Histone H3 Acetylation.International journal of molecular sciences, , May-20, Volume: 22, Issue:10, 2021
Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson's Disease: The Emerging Role of VDAC.Biomolecules, , 05-11, Volume: 11, Issue:5, 2021
How an Infection of Sheep Revealed Prion Mechanisms in Alzheimer's Disease and Other Neurodegenerative Disorders.International journal of molecular sciences, , May-04, Volume: 22, Issue:9, 2021
Proteolytic α-Synuclein Cleavage in Health and Disease.International journal of molecular sciences, , May-21, Volume: 22, Issue:11, 2021
Glucocerebrosidase Gene Therapy Induces Alpha-Synuclein Clearance and Neuroprotection of Midbrain Dopaminergic Neurons in Mice and Macaques.International journal of molecular sciences, , May-01, Volume: 22, Issue:9, 2021
Complement and Coagulation Cascades are Potentially Involved in Dopaminergic Neurodegeneration in α-Synuclein-Based Mouse Models of Parkinson's Disease.Journal of proteome research, , 07-02, Volume: 20, Issue:7, 2021
Mesenchymal stem cell secretome protects against alpha-synuclein-induced neurodegeneration in a Caenorhabditis elegans model of Parkinson's disease.Cytotherapy, , Volume: 23, Issue:10, 2021
Effects of Alpha-Synuclein Targeted Antisense Oligonucleotides on Lewy Body-Like Pathology and Behavioral Disturbances Induced by Injections of Pre-Formed Fibrils in the Mouse Motor Cortex.Journal of Parkinson's disease, , Volume: 11, Issue:3, 2021
Movement of prion-like α-synuclein along the gut-brain axis in Parkinson's disease: A potential target of curcumin treatment.The European journal of neuroscience, , Volume: 54, Issue:2, 2021
Assessment of Cytotoxicity of α-Synuclein in Budding Yeast Using a Spot Growth Assay and Fluorescent Microscopy.Methods in molecular biology (Clifton, N.J.), , Volume: 2322, 2021
α-Synuclein Propagation Mouse Models of Parkinson's Disease.Methods in molecular biology (Clifton, N.J.), , Volume: 2322, 2021
Midbrain Slice Culture as an Ex Vivo Analysis Platform for Parkinson's Disease.Methods in molecular biology (Clifton, N.J.), , Volume: 2322, 2021
Analysis of α-Synuclein in Exosomes.Methods in molecular biology (Clifton, N.J.), , Volume: 2322, 2021
α-Synuclein Seeding Assay Using Cultured Cells.Methods in molecular biology (Clifton, N.J.), , Volume: 2322, 2021
Electron Microscopic Analysis of α-Synuclein Fibrils.Methods in molecular biology (Clifton, N.J.), , Volume: 2322, 2021
Transition metal dichalcogenides to optimize the performance of peptide-imprinted conductive polymers as electrochemical sensors.Mikrochimica acta, , 05-27, Volume: 188, Issue:6, 2021
[The role of aluminum and lead in the development of Alzheimer's and Parkinson's diseases].Arkhiv patologii, , Volume: 83, Issue:3, 2021
Lycorine, a natural alkaloid, promotes the degradation of alpha-synuclein via PKA-mediated UPS activation in transgenic Parkinson's disease models.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 87, 2021
Cerebrospinal fluid α synuclein concentrations in patients with positive AD biomarkers and extrapyramidal symptoms.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 128, Issue:6, 2021
The Intersection of Parkinson's Disease, Viral Infections, and COVID-19.Molecular neurobiology, , Volume: 58, Issue:9, 2021
Development of a Sensitive Diagnostic Assay for Parkinson Disease Quantifying α-Synuclein-Containing Extracellular Vesicles.Neurology, , 05-04, Volume: 96, Issue:18, 2021
Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo.Molecular neurodegeneration, , 05-24, Volume: 16, Issue:1, 2021
Phosphorylated α-synuclein and phosphorylated tau-protein in sural nerves may contribute to differentiate Parkinson's disease from multiple system atrophy and progressive supranuclear paralysis.Neuroscience letters, , 06-21, Volume: 756, 2021
Linking Parkinson's Disease and Melanoma: Interplay Between α-Synuclein and Pmel17 Amyloid Formation.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:7, 2021
Cerebrospinal fluid and plasma distribution of anti-α-synuclein IgMs and IgGs in multiple system atrophy and Parkinson's disease.Parkinsonism & related disorders, , Volume: 87, 2021
Ellagic Acid Inhibits α-Synuclein Aggregation at Multiple Stages and Reduces Its Cytotoxicity.ACS chemical neuroscience, , 06-02, Volume: 12, Issue:11, 2021
[no title available]Frontiers in cellular and infection microbiology, , Volume: 11, 2021
Hate mail: how reactive microglia spread aggregated α-synuclein.Brain : a journal of neurology, , 08-17, Volume: 144, Issue:7, 2021
α-Synuclein in Plasma-Derived Extracellular Vesicles Is a Potential Biomarker of Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:11, 2021
Author Response: In Vivo Distribution of α-Synuclein in Multiple Tissues and Biofluids in Parkinson Disease.Neurology, , 05-18, Volume: 96, Issue:20, 2021
Reader Response: In Vivo Distribution of α-Synuclein in Multiple Tissues and Biofluids in Parkinson Disease.Neurology, , 05-18, Volume: 96, Issue:20, 2021
The food additive fast green FCF inhibits α-synuclein aggregation, disassembles mature fibrils and protects against amyloid-induced neurotoxicity.Food & function, , Jun-21, Volume: 12, Issue:12, 2021
Skin biopSYN or how to predict Parkinson's disease.Parkinsonism & related disorders, , Volume: 86, 2021
P2X7 receptor/NLRP3 inflammasome complex and α-synuclein in peripheral blood mononuclear cells: a prospective study in neo-diagnosed, treatment-naïve Parkinson's disease.European journal of neurology, , Volume: 28, Issue:8, 2021
α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson's disease from multiple system atrophy.Acta neuropathologica, , Volume: 142, Issue:3, 2021
α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology.Cell reports, , 05-11, Volume: 35, Issue:6, 2021
Lower Plasma α-Synuclein Levels are Associated with Cognitive Impairment in Parkinson's Disease.Clinical laboratory, , May-01, Volume: 67, Issue:5, 2021
Cerebrospinal α-Synuclein Oligomers Reflect Disease Motor Severity in DeNoPa Longitudinal Cohort.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:9, 2021
Prodromal sensory neuropathy in Pink1Neuropathology and applied neurobiology, , Volume: 47, Issue:7, 2021
Wild-type α-synuclein inherits the structure and exacerbated neuropathology of E46K mutant fibril strain by cross-seeding.Proceedings of the National Academy of Sciences of the United States of America, , 05-18, Volume: 118, Issue:20, 2021
Rationally Designed Protein-Based Inhibitor of α-Synuclein Fibrillization in Cells.Journal of medicinal chemistry, , 05-27, Volume: 64, Issue:10, 2021
Faster disease progression in Parkinson's disease with type 2 diabetes is not associated with increased α-synuclein, tau, amyloid-β or vascular pathology.Neuropathology and applied neurobiology, , Volume: 47, Issue:7, 2021
Update on alpha-synuclein-based biomarker approaches in the skin, submandibular gland, gastrointestinal tract, and biofluids.Current opinion in neurology, , 08-01, Volume: 34, Issue:4, 2021
[no title available]MMW Fortschritte der Medizin, , Volume: 163, Issue:9, 2021
α-synuclein aggregates induce c-Abl activation and dopaminergic neuronal loss by a feed-forward redox stress mechanism.Progress in neurobiology, , Volume: 202, 2021
Early functional changes associated with alpha-synuclein proteinopathy in engineered human neural networks.American journal of physiology. Cell physiology, , 06-01, Volume: 320, Issue:6, 2021
Cerebral dopamine neurotrophic factor reduces α-synuclein aggregation and propagation and alleviates behavioral alterations in vivo.Molecular therapy : the journal of the American Society of Gene Therapy, , 09-01, Volume: 29, Issue:9, 2021
Acteoside exerts neuroprotection effects in the model of Parkinson's disease via inducing autophagy: Network pharmacology and experimental study.European journal of pharmacology, , Jul-15, Volume: 903, 2021
Dysfunction of RAB39B-Mediated Vesicular Trafficking in Lewy Body Diseases.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:8, 2021
The Contribution of Microglia to Neuroinflammation in Parkinson's Disease.International journal of molecular sciences, , Apr-28, Volume: 22, Issue:9, 2021
Genes Implicated in Familial Parkinson's Disease Provide a Dual Picture of Nigral Dopaminergic Neurodegeneration with Mitochondria Taking Center Stage.International journal of molecular sciences, , Apr-28, Volume: 22, Issue:9, 2021
Changes in Drp1 Function and Mitochondrial Morphology Are Associated with the α-Synuclein Pathology in a Transgenic Mouse Model of Parkinson's Disease.Cells, , 04-13, Volume: 10, Issue:4, 2021
Phytochemicals as Regulators of Genes Involved in Synucleinopathies.Biomolecules, , 04-22, Volume: 11, Issue:5, 2021
NMR unveils an N-terminal interaction interface on acetylated-α-synuclein monomers for recruitment to fibrils.Proceedings of the National Academy of Sciences of the United States of America, , 05-04, Volume: 118, Issue:18, 2021
Nurr1 repression mediates cardinal features of Parkinson's disease in α-synuclein transgenic mice.Human molecular genetics, , 07-28, Volume: 30, Issue:16, 2021
Transmissible α-synuclein seeding activity in brain and stomach of patients with Parkinson's disease.Acta neuropathologica, , Volume: 141, Issue:6, 2021
Consistent skin α-synuclein positivity in REM sleep behavior disorder - A two center two-to-four-year follow-up study.Parkinsonism & related disorders, , Volume: 86, 2021
A Disease Progression Model to Quantify the Nonmotor Symptoms of Parkinson's Disease in Participants With Leucine-Rich Repeat Kinase 2 Mutation.Clinical pharmacology and therapeutics, , Volume: 110, Issue:2, 2021
Curcumin: A small molecule with big functionality against amyloid aggregation in neurodegenerative diseases and type 2 diabetes.BioFactors (Oxford, England), , Volume: 47, Issue:4, 2021
Pramipexole attenuates 6-OHDA-induced Parkinson's disease by mediating the Nurr1/NF-κB pathway.Molecular biology reports, , Volume: 48, Issue:4, 2021
Simple, rapid and sensitive detection of Parkinson's disease related alpha-synuclein using a DNA aptamer assisted liquid crystal biosensor.Soft matter, , May-12, Volume: 17, Issue:18, 2021
Does Human Alpha-Synuclein Behave Like Prions?CNS & neurological disorders drug targets, , Volume: 20, Issue:6, 2021
Alpha-Synuclein Oligomers and Neurofilament Light Chain Predict Phenoconversion of Pure Autonomic Failure.Annals of neurology, , Volume: 89, Issue:6, 2021
Ageing promotes pathological alpha-synuclein propagation and autonomic dysfunction in wild-type rats.Brain : a journal of neurology, , 07-28, Volume: 144, Issue:6, 2021
Increased Accumulation of α-Synuclein in Inflamed Appendices of Parkinson's Disease Patients.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:8, 2021
Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson's disease model.Molecular brain, , 04-19, Volume: 14, Issue:1, 2021
α-syn and SNP rs356219 as a potential biomarker in blood for Parkinson's disease in Mexican Mestizos.Neuroscience letters, , 05-29, Volume: 754, 2021
In Vivo Detection of Underlying Synucleinopathies: Are We There Yet?Neurology, , 05-18, Volume: 96, Issue:20, 2021
Parkinson's disease and the gut: Models of an emerging relationship.Acta biomaterialia, , 09-15, Volume: 132, 2021
Alpha-synuclein seeds in olfactory mucosa of patients with isolated REM sleep behaviour disorder.Brain : a journal of neurology, , 05-07, Volume: 144, Issue:4, 2021
Nanoaggregates Derived from Amyloid-beta and Alpha-synuclein Characterized by Sequential Quadruple Force Mapping.Nano letters, , 05-12, Volume: 21, Issue:9, 2021
In Vivo Diagnosis of Synucleinopathies: A Comparative Study of Skin Biopsy and RT-QuIC.Neurology, , 05-18, Volume: 96, Issue:20, 2021
Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia.Proceedings of the National Academy of Sciences of the United States of America, , 04-13, Volume: 118, Issue:15, 2021
The interplay between Glucocerebrosidase, α-synuclein and lipids in human models of Parkinson's disease.Biophysical chemistry, , Volume: 273, 2021
Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson's disease and dementia with Lewy bodies.Acta neuropathologica communications, , 04-07, Volume: 9, Issue:1, 2021
Novel therapeutic approaches for Parkinson's disease by targeting brain cholesterol homeostasis.The Journal of pharmacy and pharmacology, , Jun-08, Volume: 73, Issue:7, 2021
Oral subchronic exposure to the mycotoxin ochratoxin A induces key pathological features of Parkinson's disease in mice six months after the end of the treatment.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, , Volume: 152, 2021
Fluorescent Probe for Selective Imaging of α-Synuclein Fibrils in Living Cells.ACS chemical neuroscience, , 04-21, Volume: 12, Issue:8, 2021
Perampanel Inhibits α-Synuclein Transmission in Parkinson's Disease Models.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:7, 2021
The gut-brain connection in the pathogenicity of Parkinson disease: Putative role of autophagy.Neuroscience letters, , 05-14, Volume: 753, 2021
Could Small Heat Shock Protein HSP27 Be a First-Line Target for Preventing Protein Aggregation in Parkinson's Disease?International journal of molecular sciences, , Mar-16, Volume: 22, Issue:6, 2021
Intracerebral Administration of a Ligand-ASO Conjugate Selectively Reduces α-Synuclein Accumulation in Monoamine Neurons of Double Mutant Human A30P*A53T*α-Synuclein Transgenic Mice.International journal of molecular sciences, , Mar-13, Volume: 22, Issue:6, 2021
The Nigral Coup in Parkinson's Disease by α-Synuclein and Its Associated Rebels.Cells, , 03-09, Volume: 10, Issue:3, 2021
Reduced Interaction of Aggregated α-Synuclein and VAMP2 by Environmental Enrichment Alleviates Hyperactivity and Anxiety in a Model of Parkinson's Disease.Genes, , 03-10, Volume: 12, Issue:3, 2021
PGC-1s in the Spotlight with Parkinson's Disease.International journal of molecular sciences, , Mar-28, Volume: 22, Issue:7, 2021
Parkinson's disease: Alterations in iron and redox biology as a key to unlock therapeutic strategies.Redox biology, , Volume: 41, 2021
Antioxidant activity of calycosin against α-synuclein amyloid fibrils-induced oxidative stress in neural-like cells as a model of preventive care studies in Parkinson's disease.International journal of biological macromolecules, , Jul-01, Volume: 182, 2021
Reactive microglia enhance the transmission of exosomal α-synuclein via toll-like receptor 2.Brain : a journal of neurology, , 08-17, Volume: 144, Issue:7, 2021
Decreased AQP4 Expression Aggravates ɑ-Synuclein Pathology in Parkinson's Disease Mice, Possibly via Impaired Glymphatic Clearance.Journal of molecular neuroscience : MN, , Volume: 71, Issue:12, 2021
Effects of α-Synuclein-Associated Post-Translational Modifications in Parkinson's Disease.ACS chemical neuroscience, , 04-07, Volume: 12, Issue:7, 2021
TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration.Cell reports, , 03-23, Volume: 34, Issue:12, 2021
CSPα reduces aggregates and rescues striatal dopamine release in α-synuclein transgenic mice.Brain : a journal of neurology, , 07-28, Volume: 144, Issue:6, 2021
Progression of phosphorylated α-synuclein in Macaca fuscata.Brain pathology (Zurich, Switzerland), , Volume: 31, Issue:5, 2021
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells.Nature communications, , 03-22, Volume: 12, Issue:1, 2021
Biosensors in Parkinson's disease.Clinica chimica acta; international journal of clinical chemistry, , Volume: 518, 2021
The cell biology of Parkinson's disease.The Journal of cell biology, , 04-05, Volume: 220, Issue:4, 2021
Hydration Thermodynamics of Familial Parkinson's Disease-Linked Mutants of α-Synuclein.Journal of chemical information and modeling, , 04-26, Volume: 61, Issue:4, 2021
Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson's disease.Acta neuropathologica communications, , 03-20, Volume: 9, Issue:1, 2021
Alpha-Synuclein Handling by Microglia: Activating, Combating, and Worsening.Neuroscience bulletin, , Volume: 37, Issue:6, 2021
Dermal and cardiac autonomic fiber involvement in Parkinson's disease and multiple system atrophy.Neurobiology of disease, , Volume: 153, 2021
Alpha synuclein (SNCA) rs7684318 variant contributes to Parkinson's disease risk by altering transcription factor binding related with Notch and Wnt signaling.Neuroscience letters, , 04-17, Volume: 750, 2021
CD4 T cells mediate brain inflammation and neurodegeneration in a mouse model of Parkinson's disease.Brain : a journal of neurology, , 08-17, Volume: 144, Issue:7, 2021
α-Synuclein-induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms.Science advances, , Volume: 7, Issue:11, 2021
Reduced erythrocytic CHCHD2 mRNA is associated with brain pathology of Parkinson's disease.Acta neuropathologica communications, , 03-08, Volume: 9, Issue:1, 2021
GDNF signaling in subjects with minimal motor deficits and Parkinson's disease.Neurobiology of disease, , Volume: 153, 2021
α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson's disease.JCI insight, , 03-08, Volume: 6, Issue:5, 2021
The α-Synuclein Origin and Connectome Model (SOC Model) of Parkinson's Disease: Explaining Motor Asymmetry, Non-Motor Phenotypes, and Cognitive Decline.Journal of Parkinson's disease, , Volume: 11, Issue:2, 2021
Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies.Cells, , 02-12, Volume: 10, Issue:2, 2021
GBA Mutations Influence the Release and Pathological Effects of Small Extracellular Vesicles from Fibroblasts of Patients with Parkinson's Disease.International journal of molecular sciences, , Feb-23, Volume: 22, Issue:4, 2021
Therapeutic Potential of αS Evolvability for Neuropathic Gaucher Disease.Biomolecules, , 02-15, Volume: 11, Issue:2, 2021
[Altered dopamine metabolism and its role in pathogenesis of Parkinson's disease].Sheng li xue bao : [Acta physiologica Sinica], , Feb-25, Volume: 73, Issue:1, 2021
Investigating the relationship between the SNCA gene and cognitive abilities in idiopathic Parkinson's disease using machine learning.Scientific reports, , 03-01, Volume: 11, Issue:1, 2021
[Therapeutic strategy for Parkinson's disease: targeting zinc-binding protein in astrocytes].Nihon yakurigaku zasshi. Folia pharmacologica Japonica, , Volume: 156, Issue:2, 2021
Ghrelin protects against rotenone-induced cytotoxicity: Involvement of mitophagy and the AMPK/SIRT1/PGC1α pathway.Neuropeptides, , Volume: 87, 2021
Age-related increase of alpha-synuclein oligomers is associated with motor disturbances in L61 transgenic mice.Neurobiology of aging, , Volume: 101, 2021
Ecto-GPR37: a potential biomarker for Parkinson's disease.Translational neurodegeneration, , 02-26, Volume: 10, Issue:1, 2021
Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain.Acta neuropathologica communications, , 02-25, Volume: 9, Issue:1, 2021
Parkinson's Disease-Associated LRRK2 Interferes with Astrocyte-Mediated Alpha-Synuclein Clearance.Molecular neurobiology, , Volume: 58, Issue:7, 2021
Profiling the Biochemical Signature of GBA-Related Parkinson's Disease in Peripheral Blood Mononuclear Cells.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:5, 2021
A Novel SNCA A30G Mutation Causes Familial Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:7, 2021
Brazilin Removes Toxic Alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium.Journal of molecular biology, , 04-16, Volume: 433, Issue:8, 2021
Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study.The Lancet. Neurology, , Volume: 20, Issue:3, 2021
Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models.Communications biology, , 02-19, Volume: 4, Issue:1, 2021
Retina as a Model to Study In Vivo Transmission of α-Synuclein in the A53T Mouse Model of Parkinson's Disease.Methods in molecular biology (Clifton, N.J.), , Volume: 2224, 2021
Investigating ELOVL7 coding variants in multiple system atrophy.Neuroscience letters, , 04-01, Volume: 749, 2021
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture.Nature genetics, , Volume: 53, Issue:3, 2021
α-Synuclein plasma membrane localization correlates with cellular phosphatidylinositol polyphosphate levels.eLife, , 02-15, Volume: 10, 2021
T Cells Limit Accumulation of Aggregate Pathology Following Intrastriatal Injection of α-Synuclein Fibrils.Journal of Parkinson's disease, , Volume: 11, Issue:2, 2021
α-Synuclein Heteromers in Red Blood Cells of Alzheimer's Disease and Lewy Body Dementia Patients.Journal of Alzheimer's disease : JAD, , Volume: 80, Issue:2, 2021
Interaction between Parkin and Cells, , 01-31, Volume: 10, Issue:2, 2021
Crowded organelles, lipid accumulation, and abnormal membrane tubulation in cellular models of enhanced α-synuclein membrane interaction.Brain research, , 05-01, Volume: 1758, 2021
Influence of Lipid Membranes on α-Synuclein Aggregation.ACS chemical neuroscience, , 03-03, Volume: 12, Issue:5, 2021
REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 04-21, Volume: 41, Issue:16, 2021
Synthesis of Double Interfering Biodegradable Nano-MgO Micelle Composites and Their Effect on Parkinson's Disease.ACS biomaterials science & engineering, , 03-08, Volume: 7, Issue:3, 2021
In vivo aggregation of presynaptic alpha-synuclein is not influenced by its phosphorylation at serine-129.Neurobiology of disease, , Volume: 152, 2021
α-synuclein impairs autophagosome maturation through abnormal actin stabilization.PLoS genetics, , Volume: 17, Issue:2, 2021
Swertiamarin from Enicostemma littorale, counteracts PD associated neurotoxicity via enhancement α-synuclein suppressive genes and SKN-1/NRF-2 activation through MAPK pathway.Bioorganic chemistry, , Volume: 108, 2021
The Mutation Matters: CSF Profiles of GCase, Sphingolipids, α-Synuclein in PDMovement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:5, 2021
Long Non-coding RNAs in Parkinson's Disease.Neurochemical research, , Volume: 46, Issue:5, 2021
Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.Chemical reviews, , 02-24, Volume: 121, Issue:4, 2021
Membrane Remodeling and Stimulation of Aggregation Following α-Synuclein Adsorption to Phosphotidylserine Vesicles.The journal of physical chemistry. B, , 02-18, Volume: 125, Issue:6, 2021
How gut microbes could drive brain disorders.Nature, , Volume: 590, Issue:7844, 2021
Peripheral synucleinopathy in Parkinson disease with LRRK2 G2385R variants.Annals of clinical and translational neurology, , Volume: 8, Issue:3, 2021
Poly (ADP-ribose) polymerase 1 and Parkinson's disease: A study in post-mortem human brain.Neurochemistry international, , Volume: 144, 2021
Dihydroquinazolines enhance 20S proteasome activity and induce degradation of α-synuclein, an intrinsically disordered protein associated with neurodegeneration.Bioorganic & medicinal chemistry letters, , 03-15, Volume: 36, 2021
Single-Molecule Counting Coupled to Rapid Amplification Enables Detection of α-Synuclein Aggregates in Cerebrospinal Fluid of Parkinson's Disease Patients.Angewandte Chemie (International ed. in English), , 05-17, Volume: 60, Issue:21, 2021
α-Synuclein evokes NLRP3 inflammasome-mediated IL-1β secretion from primary human microglia.Glia, , Volume: 69, Issue:6, 2021
Velvet Antler Methanol Extracts Ameliorate Parkinson's Disease by Inhibiting Oxidative Stress and Neuroinflammation: From Oxidative medicine and cellular longevity, , Volume: 2021, 2021
A growth-factor-activated lysosomal KNature, , Volume: 591, Issue:7850, 2021
Potential treatment of Parkinson's disease using new-generation carbon nanotubes: a biomolecular Nanomedicine (London, England), , Volume: 16, Issue:3, 2021
Potential of extracellular vesicles in the Parkinson's disease - Pathological mediators and biomarkers.Neurochemistry international, , Volume: 144, 2021
The Localization of Alpha-synuclein in the Endocytic Pathway.Neuroscience, , 03-01, Volume: 457, 2021
Sigma-2 receptor antagonists rescue neuronal dysfunction induced by Parkinson's patient brain-derived α-synuclein.Journal of neuroscience research, , Volume: 99, Issue:4, 2021
The role of innate immunity and inflammation in Parkinson´s disease.Scandinavian journal of immunology, , Volume: 93, Issue:5, 2021
Global and Regional Changes in Perivascular Space in Idiopathic and Familial Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:5, 2021
Inhibition of Orexin/Hypocretin Neurons Ameliorates Elevated Physical Activity and Energy Expenditure in the A53T Mouse Model of Parkinson's Disease.International journal of molecular sciences, , Jan-14, Volume: 22, Issue:2, 2021
Impaired meningeal lymphatic drainage in patients with idiopathic Parkinson's disease.Nature medicine, , Volume: 27, Issue:3, 2021
Metabotropic glutamate receptor 5 inhibits α-synuclein-induced microglia inflammation to protect from neurotoxicity in Parkinson's disease.Journal of neuroinflammation, , Jan-18, Volume: 18, Issue:1, 2021
Therapies for Genetic Forms of Parkinson's Disease: Systematic Literature Review.Journal of neuromuscular diseases, , Volume: 8, Issue:3, 2021
Inflammation and Parkinson's disease pathogenesis: Mechanisms and therapeutic insight.Progress in molecular biology and translational science, , Volume: 177, 2021
Expression Levels of an Alpha-Synuclein Transcript in Blood May Distinguish between Early Dementia with Lewy Bodies and Parkinson's Disease.International journal of molecular sciences, , Jan-13, Volume: 22, Issue:2, 2021
Cross-talks among GBA mutations, glucocerebrosidase, and α-synuclein in GBA-associated Parkinson's disease and their targeted therapeutic approaches: a comprehensive review.Translational neurodegeneration, , 01-15, Volume: 10, Issue:1, 2021
Seeding Propensity and Characteristics of Pathogenic αSyn Assemblies in Formalin-Fixed Human Tissue from the Enteric Nervous System, Olfactory Bulb, and Brainstem in Cases Staged for Parkinson's Disease.Cells, , 01-12, Volume: 10, Issue:1, 2021
A SUMO1-Derived Peptide Targeting SUMO-Interacting Motif Inhibits α-Synuclein Aggregation.Cell chemical biology, , 02-18, Volume: 28, Issue:2, 2021
The Parkinson's disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release.Proceedings of the National Academy of Sciences of the United States of America, , 01-05, Volume: 118, Issue:1, 2021
Human α-synuclein overexpression in a mouse model of Parkinson's disease leads to vascular pathology, blood brain barrier leakage and pericyte activation.Scientific reports, , 01-13, Volume: 11, Issue:1, 2021
Intranasal administration of α-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis.Cell death & disease, , 01-13, Volume: 12, Issue:1, 2021
Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease.Nature chemical biology, , Volume: 17, Issue:3, 2021
The TCR repertoire of α-synuclein-specific T cells in Parkinson's disease is surprisingly diverse.Scientific reports, , 01-11, Volume: 11, Issue:1, 2021
Targeted attenuation of elevated histone marks at SNCA alleviates α-synuclein in Parkinson's disease.EMBO molecular medicine, , 02-05, Volume: 13, Issue:2, 2021
Targeted graphene oxide for drug delivery as a therapeutic nanoplatform against Parkinson's disease.Biomaterials science, , Mar-10, Volume: 9, Issue:5, 2021
Is SGSH heterozygosity a risk factor for early-onset neurodegenerative disease?Journal of inherited metabolic disease, , Volume: 44, Issue:3, 2021
Distinguishing normal and aggregated alpha-synuclein interaction on gold nanorod incorporated zinc oxide nanocomposite by electrochemical technique.International journal of biological macromolecules, , Feb-28, Volume: 171, 2021
14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril model.Acta neuropathologica communications, , 01-07, Volume: 9, Issue:1, 2021
How microcompetition with latent viruses can cause α synuclein aggregation, mitochondrial dysfunction, and eventually Parkinson's disease.Journal of neurovirology, , Volume: 27, Issue:1, 2021
Is Gut Dysbiosis an Epicenter of Parkinson's Disease?Neurochemical research, , Volume: 46, Issue:3, 2021
Increased glutamate transmission onto dorsal striatum spiny projection neurons in Pink1 knockout rats.Neurobiology of disease, , Volume: 150, 2021
Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies.Journal of molecular cell biology, , 08-04, Volume: 13, Issue:4, 2021
Interactions of α-synuclein oligomers with lipid membranes.Biochimica et biophysica acta. Biomembranes, , 04-01, Volume: 1863, Issue:4, 2021
A rapid α-synuclein seed assay of Parkinson's disease CSF panel shows high diagnostic accuracy.Annals of clinical and translational neurology, , Volume: 8, Issue:2, 2021
MOBP and HIP1 in multiple system atrophy: New α-synuclein partners in glial cytoplasmic inclusions implicated in the disease pathogenesis.Neuropathology and applied neurobiology, , Volume: 47, Issue:5, 2021
Grafts Derived from an α-Synuclein Triplication Patient Mediate Functional Recovery but Develop Disease-Associated Pathology in the 6-OHDA Model of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 11, Issue:2, 2021
Chitosan nanocarrier for FTY720 enhanced delivery retards Parkinson's disease via PP2A-EzH2 signaling in vitro and ex vivo.Carbohydrate polymers, , Feb-15, Volume: 254, 2021
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Role of RhoA-ROCK signaling in Parkinson's disease.European journal of pharmacology, , Mar-05, Volume: 894, 2021
Alpha-Synuclein oligomerization and aggregation: All models are useful but only if we know what they model: This is the reply to a comment "Alpha-synuclein oligomerization and aggregation: A model will always be a model" on the original article "MonitorinJournal of neurochemistry, , Volume: 157, Issue:4, 2021
Molecular events underlying the cell-to-cell transmission of α-synuclein.The FEBS journal, , Volume: 288, Issue:23, 2021
Soluble CD163 Changes Indicate Monocyte Association With Cognitive Deficits in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:4, 2021
Mitochondrial Dysfunction and Mitophagy in Parkinson's Disease: From Mechanism to Therapy.Trends in biochemical sciences, , Volume: 46, Issue:4, 2021
Glial activation precedes alpha-synuclein pathology in a mouse model of Parkinson's disease.Neuroscience research, , Volume: 170, 2021
Genetic and Environmental Factors in Parkinson's Disease Converge on Immune Function and Inflammation.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:1, 2021
Proteomic analysis of subcellular compartments containing disseminated alpha-synuclein seeds.Neuroscience research, , Volume: 170, 2021
A population scale analysis of rare SNCA variation in the UK Biobank.Neurobiology of disease, , Volume: 148, 2021
Alpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a Parkinson's disease patient (PARK4) with SNCA triplication.FEBS open bio, , Volume: 11, Issue:2, 2021
Exosome-mediated delivery of antisense oligonucleotides targeting α-synuclein ameliorates the pathology in a mouse model of Parkinson's disease.Neurobiology of disease, , Volume: 148, 2021
Epitope imprinting of alpha-synuclein for sensing in Parkinson's brain organoid culture medium.Biosensors & bioelectronics, , Mar-01, Volume: 175, 2021
Activating transcription factor-4 promotes neuronal death induced by Parkinson's disease neurotoxins and α-synuclein aggregates.Cell death and differentiation, , Volume: 28, Issue:5, 2021
α-synuclein abnormalities trigger focal tau pathology, spreading to various brain areas in Parkinson disease.Journal of neurochemistry, , Volume: 157, Issue:3, 2021
Reply: Growth differentiation factor 5 exerts neuroprotection in an α-synuclein rat model of Parkinson's disease and BMP5/7 protect dopaminergic neurons in an α-synuclein mouse model of Parkinson's disease.Brain : a journal of neurology, , 03-03, Volume: 144, Issue:2, 2021
Growth differentiation factor 5 exerts neuroprotection in an α-synuclein rat model of Parkinson's disease.Brain : a journal of neurology, , 03-03, Volume: 144, Issue:2, 2021
BMP5/7 protect dopaminergic neurons in an α-synuclein mouse model of Parkinson's disease.Brain : a journal of neurology, , 03-03, Volume: 144, Issue:2, 2021
Inhibition of copper transporter 1 prevents α-synuclein pathology and alleviates nigrostriatal degeneration in AAV-based mouse model of Parkinson's disease.Redox biology, , Volume: 38, 2021
Immunohistochemical Detection of Synuclein Pathology in Skin in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:4, 2021
The MHC class II transactivator modulates seeded alpha-synuclein pathology and dopaminergic neurodegeneration in an in vivo rat model of Parkinson's disease.Brain, behavior, and immunity, , Volume: 91, 2021
The Role of Cholesterol in α-Synuclein and Lewy Body Pathology in GBA1 Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:5, 2021
Oligomeric α-Syn and SNARE complex proteins in peripheral extracellular vesicles of neural origin are biomarkers for Parkinson's disease.Neurobiology of disease, , Volume: 148, 2021
Upregulation of enteric alpha-synuclein as a possible link between inflammatory bowel disease and Parkinson's disease.Gut, , Volume: 70, Issue:10, 2021
Psychosis-Like Behavior and Hyperdopaminergic Dysregulation in Human α-Synuclein BAC Transgenic Rats.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:3, 2021
From iPS Cells to Rodents and Nonhuman Primates: Filling Gaps in Modeling Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:4, 2021
Increased telomerase improves motor function and alpha-synuclein pathology in a transgenic mouse model of Parkinson's disease associated with enhanced autophagy.Progress in neurobiology, , Volume: 199, 2021
Seven Solutions for Neuroprotection in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:2, 2021
From inflammasome to Parkinson's disease: Does the NLRP3 inflammasome facilitate exosome secretion and exosomal alpha-synuclein transmission in Parkinson's disease?Experimental neurology, , Volume: 336, 2021
Neuronal Bmi-1 is critical for melatonin induced ubiquitination and proteasomal degradation of α-synuclein in experimental Parkinson's disease models.Neuropharmacology, , 08-15, Volume: 194, 2021
Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient-Derived Neurons.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:3, 2021
Sulfate reducing gut bacteria and Parkinson's disease.European journal of neurology, , Volume: 28, Issue:3, 2021
Alpha-synuclein seeds of Parkinson's disease show high prion-exceeding resistance to steam sterilization.The Journal of hospital infection, , Volume: 108, 2021
Treating Parkinson's Disease with Antibodies: Previous Studies and Future Directions.Journal of Parkinson's disease, , Volume: 11, Issue:1, 2021
Upregulation of Cellular Palmitoylation Mitigates α-Synuclein Accumulation and Neurotoxicity.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:2, 2021
α-Synuclein modulates tau spreading in mouse brains.The Journal of experimental medicine, , 01-04, Volume: 218, Issue:1, 2021
Fragmentation of the Golgi complex of dopaminergic neurons in human substantia nigra: New cytopathological findings in Parkinson's disease.Histology and histopathology, , Volume: 36, Issue:1, 2021
EphA1 Activation Induces Neuropathological Changes in a Mouse Model of Parkinson's Disease Through the CXCL12/CXCR4 Signaling Pathway.Molecular neurobiology, , Volume: 58, Issue:3, 2021
Herbal Resources to Combat a Progressive & Degenerative Nervous System Disorder- Parkinson's Disease.Current drug targets, , Volume: 22, Issue:6, 2021
Extracellular clusterin limits the uptake of α-synuclein fibrils by murine and human astrocytes.Glia, , Volume: 69, Issue:3, 2021
Pathophysiology of Parkinson's disease: Mitochondria, alpha-synuclein and much more….Revue neurologique, , Volume: 177, Issue:3, 2021
A New Synuclein-Transgenic Mouse Model for Early Parkinson's Reveals Molecular Features of Preclinical Disease.Molecular neurobiology, , Volume: 58, Issue:2, 2021
A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α-Synuclein Mice.Annals of neurology, , Volume: 89, Issue:1, 2021
Reduction of Lewy Body Pathology by Oral Cinnamon.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 16, Issue:3, 2021
α-Synuclein in Parkinson's Disease: Does a Prion-Like Mechanism of Propagation from Periphery to the Brain Play a Role?The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, , Volume: 27, Issue:4, 2021
Ferroptosis and its potential role in the physiopathology of Parkinson's Disease.Progress in neurobiology, , Volume: 196, 2021
Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 41, Issue:5, 2021
Peripheral inflammation exacerbates α-synuclein toxicity and neuropathology in Parkinson's models.Neuropathology and applied neurobiology, , Volume: 47, Issue:1, 2021
STochastic Optical Reconstruction Microscopy (STORM) reveals the nanoscale organization of pathological aggregates in human brain.Neuropathology and applied neurobiology, , Volume: 47, Issue:1, 2021
[Non-motor symptoms of Parkinson's disease from pathophysiology to early diagnosis].La Revue de medecine interne, , Volume: 42, Issue:4, 2021
Lipotoxicity Downstream of α-Synuclein Imbalance: A Relevant Pathomechanism in Synucleinopathies?Biomolecules, , 12-28, Volume: 12, Issue:1, 2021
The Alpha-Synuclein RT-QuIC Products Generated by the Olfactory Mucosa of Patients with Parkinson's Disease and Multiple System Atrophy Induce Inflammatory Responses in SH-SY5Y Cells.Cells, , 12-28, Volume: 11, Issue:1, 2021
Molecular Tuning of the Nano-Bio Interface: Alpha-Synuclein's Surface Targeting with Doped Carbon Nanostructures.ACS applied bio materials, , 08-16, Volume: 4, Issue:8, 2021
Therapeutic potential of hesperidin in Parkinson's disease with dementia: inhibition of alpha synuclein and amyloid beta in Drosophila melanogaster.Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, , Jun-30, Volume: 36, Issue:1, 2021
Bioinformatics Approaches for Parkinson's Disease in Clinical Practice: Data-Driven Biomarkers and Pharmacological Treatment.Advances in experimental medicine and biology, , Volume: 1338, 2021
Development of a Protein Biochip Platform for Parkinson's Disease.Advances in experimental medicine and biology, , Volume: 1338, 2021
Ellagic Acid Prevents α-Synuclein Aggregation and Protects SH-SY5Y Cells from Aggregated α-Synuclein-Induced Toxicity via Suppression of Apoptosis and Activation of Autophagy.International journal of molecular sciences, , Dec-13, Volume: 22, Issue:24, 2021
SNCA 3' UTR Genetic Variants in Patients with Parkinson's Disease.Biomolecules, , 11-30, Volume: 11, Issue:12, 2021
Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson's Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment.Frontiers in immunology, , Volume: 12, 2021
Neuropathology and molecular diagnosis of Synucleinopathies.Molecular neurodegeneration, , 12-18, Volume: 16, Issue:1, 2021
Discrimination of MSA-P and MSA-C by RT-QuIC analysis of olfactory mucosa: the first assessment of assay reproducibility between two specialized laboratories.Molecular neurodegeneration, , 12-11, Volume: 16, Issue:1, 2021
Decrease in International journal of molecular sciences, , Nov-23, Volume: 22, Issue:23, 2021
Pharmacological inhibition and knockdown of O-GlcNAcase reduces cellular internalization of α-synuclein preformed fibrils.The FEBS journal, , Volume: 288, Issue:2, 2021
Slow-wave sleep affects synucleinopathy and regulates proteostatic processes in mouse models of Parkinson's disease.Science translational medicine, , 12-08, Volume: 13, Issue:623, 2021
Ten Unsolved Questions About Neuroinflammation in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:1, 2021
Astaxanthin suppresses endoplasmic reticulum stress and protects against neuron damage in Parkinson's disease by regulating miR-7/SNCA axis.Neuroscience research, , Volume: 165, 2021
Updates on the Genetics of Parkinson's Disease: Clinical Implications and Future Treatment.Acta neurologica Taiwanica, , Sep-30, Volume: 30(3), 2021
Lentiviral Vectors Expressing Chimeric NEDD4 Ubiquitin Ligases: An Innovative Approach for Interfering with Alpha-Synuclein Accumulation.Cells, , 11-21, Volume: 10, Issue:11, 2021
(De)stabilization of Alpha-Synuclein Fibrillary Aggregation by Charged and Uncharged Surfactants.International journal of molecular sciences, , Nov-19, Volume: 22, Issue:22, 2021
Protein Misfolding and Aggregation: The Relatedness between Parkinson's Disease and Hepatic Endoplasmic Reticulum Storage Disorders.International journal of molecular sciences, , Nov-18, Volume: 22, Issue:22, 2021
Polymorphism of Alpha-Synuclein Amyloid Fibrils Depends on Ionic Strength and Protein Concentration.International journal of molecular sciences, , Nov-17, Volume: 22, Issue:22, 2021
Sgt1 Regulates α-Synuclein Subcellular Localization and Expression of Parkinson's Disease Related Genes, Biomolecules, , 11-11, Volume: 11, Issue:11, 2021
α-synuclein suppresses microglial autophagy and promotes neurodegeneration in a mouse model of Parkinson's disease.Aging cell, , Volume: 20, Issue:12, 2021
α-Synuclein antisense transcript SNCA-AS1 regulates synapses- and aging-related genes suggesting its implication in Parkinson's disease.Aging cell, , Volume: 20, Issue:12, 2021
Abnormal accumulation of lipid droplets in neurons induces the conversion of alpha-Synuclein to proteolytic resistant forms in a Drosophila model of Parkinson's disease.PLoS genetics, , Volume: 17, Issue:11, 2021
Clinical and molecular genetic findings of hereditary Parkinson's patients from Turkey.Parkinsonism & related disorders, , Volume: 93, 2021
Ca2+ administration prevents α-synuclein proteotoxicity by stimulating calcineurin-dependent lysosomal proteolysis.PLoS genetics, , Volume: 17, Issue:11, 2021
Design, synthesis and structure-activity evaluation of novel 2-pyridone-based inhibitors of α-synuclein aggregation with potentially improved BBB permeability.Bioorganic chemistry, , Volume: 117, 2021
Mechanistic Insight from Preclinical Models of Parkinson's Disease Could Help Redirect Clinical Trial Efforts in GDNF Therapy.International journal of molecular sciences, , Oct-28, Volume: 22, Issue:21, 2021
Chronic Exposure to Paraquat Induces Alpha-Synuclein Pathogenic Modifications in International journal of molecular sciences, , Oct-27, Volume: 22, Issue:21, 2021
The Bacterial Amyloids Phenol Soluble Modulins from International journal of molecular sciences, , Oct-27, Volume: 22, Issue:21, 2021
Effects of the Toxic Metals Arsenite and Cadmium on α-Synuclein Aggregation In Vitro and in Cells.International journal of molecular sciences, , Oct-24, Volume: 22, Issue:21, 2021
Neuropathological evidence of body-first vs. brain-first Lewy body disease.Neurobiology of disease, , Volume: 161, 2021
Gene-corrected p.A30P SNCA patient-derived isogenic neurons rescue neuronal branching and function.Scientific reports, , 11-09, Volume: 11, Issue:1, 2021
Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein.Acta neuropathologica communications, , 11-08, Volume: 9, Issue:1, 2021
Diagnostic utility of fluid biomarkers in multiple system atrophy: a systematic review and meta-analysis.Journal of neurology, , Volume: 268, Issue:8, 2021
High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson's disease.Acta neuropathologica communications, , 11-06, Volume: 9, Issue:1, 2021
Glucocerebrosidase mutations: A paradigm for neurodegeneration pathways.Free radical biology & medicine, , 11-01, Volume: 175, 2021
Epigenetic inactivation of the autophagy-lysosomal system in appendix in Parkinson's disease.Nature communications, , 08-26, Volume: 12, Issue:1, 2021
ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease.Neurobiology of disease, , Volume: 161, 2021
[Neuroprotective treatment of idiopathic, genetic and atypical Parkinson's disease with alpha-synuclein-Pathology].Der Nervenarzt, , Volume: 92, Issue:12, 2021
Neurorescue Effects of Frondoside A and Ginsenoside Rg3 in Molecules (Basel, Switzerland), , Aug-10, Volume: 26, Issue:16, 2021
Lipid Peroxidation Products HNE and ONE Promote and Stabilize Alpha-Synuclein Oligomers by Chemical Modifications.Biochemistry, , 11-30, Volume: 60, Issue:47, 2021
Roles for α-Synuclein in Gene Expression.Genes, , 07-29, Volume: 12, Issue:8, 2021
Synuclein Family Members Prevent Membrane Damage by Counteracting α-Synuclein Aggregation.Biomolecules, , 07-21, Volume: 11, Issue:8, 2021
Monitoring of a progressive functional dopaminergic deficit in the A53T-AAV synuclein rats by combining 6-[Neurobiology of aging, , Volume: 107, 2021
Association between CSF alpha-synuclein seeding activity and genetic status in Parkinson's disease and dementia with Lewy bodies.Acta neuropathologica communications, , 10-30, Volume: 9, Issue:1, 2021
Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity.Nature communications, , 10-29, Volume: 12, Issue:1, 2021
Modulating α-Synuclein Liquid-Liquid Phase Separation.Biochemistry, , 12-07, Volume: 60, Issue:48, 2021
Cross-sectional associations of cerebrospinal α-synuclein, tau and amyloid-β with dyskinesias, motor fluctuations, non-motor symptoms in a cohort of Parkinson's disease patients.Journal of the neurological sciences, , Nov-15, Volume: 430, 2021
C/EBPβ/δ-secretase signaling mediates Parkinson's disease pathogenesis via regulating transcription and proteolytic cleavage of α-synuclein and MAOB.Molecular psychiatry, , Volume: 26, Issue:2, 2021
Fatal attraction - The role of hypoxia when alpha-synuclein gets intimate with mitochondria.Neurobiology of aging, , Volume: 107, 2021
A Downsized and Optimised Intracellular Library-Derived Peptide Prevents Alpha-Synuclein Primary Nucleation and Toxicity Without Impacting Upon Lipid Binding.Journal of molecular biology, , 12-03, Volume: 433, Issue:24, 2021
Toxic Feedback Loop Involving Iron, Reactive Oxygen Species, α-Synuclein and Neuromelanin in Parkinson's Disease and Intervention with Turmeric.Molecular neurobiology, , Volume: 58, Issue:11, 2021
[Risk and course of COVID-19 in patients with Parkinson's disease].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, , Volume: 121, Issue:9, 2021
Identification of new alpha-synuclein fibrillogenesis inhibitor using in silico structure-based virtual screening.Journal of molecular graphics & modelling, , Volume: 108, 2021
Targeting Microglial α-Synuclein/TLRs/NF-kappaB/NLRP3 Inflammasome Axis in Parkinson's Disease.Frontiers in immunology, , Volume: 12, 2021
Constitutive silencing of LRRK2 kinase activity leads to early glucocerebrosidase deregulation and late impairment of autophagy in vivo.Neurobiology of disease, , Volume: 159, 2021
Unexpected Implication of SRP and AGO2 in Parkinson's Disease: Involvement in Alpha-Synuclein Biogenesis.Cells, , 10-18, Volume: 10, Issue:10, 2021
Mitochondrial Dysfunction, Protein Misfolding and Neuroinflammation in Parkinson's Disease: Roads to Biomarker Discovery.Biomolecules, , 10-13, Volume: 11, Issue:10, 2021
DJ-1 Acts as a Scavenger of α-Synuclein Oligomers and Restores Monomeric Glycated α-Synuclein.Biomolecules, , 10-06, Volume: 11, Issue:10, 2021
Roles of α‑synuclein in gastrointestinal microbiome dysbiosis‑related Parkinson's disease progression (Review).Molecular medicine reports, , Volume: 24, Issue:4, 2021
Structural and Functional Insights into α-Synuclein Fibril Polymorphism.Biomolecules, , 09-28, Volume: 11, Issue:10, 2021
Update on the association between alpha-synuclein and tau with mitochondrial dysfunction: Implications for Parkinson's disease.The European journal of neuroscience, , Volume: 53, Issue:9, 2021
Enhanced Plasmonic Biosensor Utilizing Paired Antibody and Label-Free FeBiosensors, , Oct-18, Volume: 11, Issue:10, 2021
Insights into the Mechanistic Perspective Effect of Insulin on the Nonamyloidogenic Component (NAC) and α-Synuclein Aggregation.ACS chemical neuroscience, , 09-01, Volume: 12, Issue:17, 2021
Deficient immunoproteasome assembly drives gain of α-synuclein pathology in Parkinson's disease.Redox biology, , Volume: 47, 2021
Astrocyte dysfunction in Parkinson's disease: from the perspectives of transmitted α-synuclein and genetic modulation.Translational neurodegeneration, , 10-18, Volume: 10, Issue:1, 2021
What substance P might tell us about the prognosis and mechanism of Parkinson's disease?Neuroscience and biobehavioral reviews, , Volume: 131, 2021
The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends.Nature communications, , 10-14, Volume: 12, Issue:1, 2021
TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease.Neuron, , 12-01, Volume: 109, Issue:23, 2021
Peiminine Reduces ARTS-Mediated Degradation of XIAP by Modulating the PINK1/Parkin Pathway to Ameliorate 6-Hydroxydopamine Toxicity and α-Synuclein Accumulation in Parkinson's Disease Models In Vivo and In Vitro.International journal of molecular sciences, , Sep-23, Volume: 22, Issue:19, 2021
Iron as the concert master in the pathogenic orchestra playing in sporadic Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 128, Issue:10, 2021
Molecular chaperones and Parkinson's disease.Neurobiology of disease, , Volume: 160, 2021
Biofluids profile of α-Klotho in patients with Parkinson's disease.Parkinsonism & related disorders, , Volume: 90, 2021
Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption.Nature communications, , 10-08, Volume: 12, Issue:1, 2021
Alpha-synuclein pathology, microgliosis, and parvalbumin neuron loss in the amygdala associated with enhanced fear in the Thy1-aSyn model of Parkinson's disease.Neurobiology of disease, , Volume: 158, 2021
Discovery of styrylaniline derivatives as novel alpha-synuclein aggregates ligands.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
DNAJB6 suppresses alpha-synuclein induced pathology in an animal model of Parkinson's disease.Neurobiology of disease, , Volume: 158, 2021
Direct targeting of wild-type glucocerebrosidase by antipsychotic quetiapine improves pathogenic phenotypes in Parkinson's disease models.JCI insight, , 10-08, Volume: 6, Issue:19, 2021
Biomarkers of neurodegeneration and glial activation validated in Alzheimer's disease assessed in longitudinal cerebrospinal fluid samples of Parkinson's disease.PloS one, , Volume: 16, Issue:10, 2021
Parkinson's disease risk genes act in glia to control neuronal α-synuclein toxicity.Neurobiology of disease, , Volume: 159, 2021
Polo-like kinase 2 inhibition reduces serine-129 phosphorylation of physiological nuclear alpha-synuclein but not of the aggregated alpha-synuclein.PloS one, , Volume: 16, Issue:10, 2021
Cationic Carbosilane Dendrimers Prevent Abnormal α-Synuclein Accumulation in Parkinson's Disease Patient-Specific Dopamine Neurons.Biomacromolecules, , 11-08, Volume: 22, Issue:11, 2021
Evaluation of Strategies for Measuring Lysosomal Glucocerebrosidase Activity.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:12, 2021
Neuroprotective effect of metformin on dopaminergic neurodegeneration and α-synuclein aggregation in C. elegans model of Parkinson's disease.Neuroscience research, , Volume: 162, 2021
Variable expression of mitochondrial complex IV in the course of nigral intracellular accumulation of α-synuclein.Parkinsonism & related disorders, , Volume: 90, 2021
Alpha Synuclein only Forms Fibrils In Vitro when Larger than its Critical Size of 70 Monomers.Chembiochem : a European journal of chemical biology, , 10-01, Volume: 22, Issue:19, 2021
Studying the effect of alpha-synuclein and Parkinson's disease linked mutants on inter pathway connectivities.Scientific reports, , 08-11, Volume: 11, Issue:1, 2021
Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson's disease.Communications biology, , 09-29, Volume: 4, Issue:1, 2021
Queuine, a bacterial-derived hypermodified nucleobase, shows protection in in vitro models of neurodegeneration.PloS one, , Volume: 16, Issue:8, 2021
Integration of functional genomics data to uncover cell type-specific pathways affected in Parkinson's disease.Biochemical Society transactions, , 11-01, Volume: 49, Issue:5, 2021
The Neural Gut-Brain Axis of Pathological Protein Aggregation in Parkinson's Disease and Its Counterpart in Peroral Prion Infections.Viruses, , 07-18, Volume: 13, Issue:7, 2021
The link between the gut microbiota and Parkinson's Disease: A systematic mechanism review with focus on α-synuclein transport.Brain research, , 10-15, Volume: 1769, 2021
Is Multiple System Atrophy a Prion-like Disorder?International journal of molecular sciences, , Sep-18, Volume: 22, Issue:18, 2021
Gut brain axis: an insight into microbiota role in Parkinson's disease.Metabolic brain disease, , Volume: 36, Issue:7, 2021
Alpha-Synuclein and the Endolysosomal System in Parkinson's Disease: Guilty by Association.Biomolecules, , 09-09, Volume: 11, Issue:9, 2021
Alpha-Synuclein and Lipids: The Elephant in the Room?Cells, , 09-17, Volume: 10, Issue:9, 2021
ATH434 Reverses Colorectal Dysfunction in the A53T Mouse Model of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 11, Issue:4, 2021
Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Familial Parkinson's Disease Patients Display α-Synuclein Pathology and Abnormal Mitochondrial Morphology.Cells, , 09-13, Volume: 10, Issue:9, 2021
α-Synuclein Decreases the Abundance of Proteasome Subunits and Alters Ubiquitin Conjugates in Yeast.Cells, , 08-28, Volume: 10, Issue:9, 2021
Transcutaneous vagus nerve stimulation (tVNS) as a potential therapeutic application for neurodegenerative disorders - A focus on dysautonomia in Parkinson's disease.Autonomic neuroscience : basic & clinical, , Volume: 235, 2021
Selectivity of Lewy body protein interactions along the aggregation pathway of α-synuclein.Communications biology, , 09-23, Volume: 4, Issue:1, 2021
N-γ-(L-glutamyl)-L-selenomethionine shows neuroprotective effects against Parkinson's disease associated with SKN-1/Nrf2 and TRXR-1 in Caenorhabditis elegans.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 92, 2021
Alternative platelet activation pathways and their role in neurodegenerative diseases.Neurobiology of disease, , Volume: 159, 2021
The Prion-Like Spreading of Alpha-Synuclein in Parkinson's Disease: Update on Models and Hypotheses.International journal of molecular sciences, , Aug-03, Volume: 22, Issue:15, 2021
Heterozygous GBA D409V and ATP13a2 mutations do not exacerbate pathological α-synuclein spread in the prodromal preformed fibrils model in young mice.Neurobiology of disease, , Volume: 159, 2021
Ncx3-Induced Mitochondrial Dysfunction in Midbrain Leads to Neuroinflammation in Striatum of A53t-α-Synuclein Transgenic Old Mice.International journal of molecular sciences, , Jul-30, Volume: 22, Issue:15, 2021
Systemic α-synuclein injection triggers selective neuronal pathology as seen in patients with Parkinson's disease.Molecular psychiatry, , Volume: 26, Issue:2, 2021
Parkinson's disease outside the brain: targeting the autonomic nervous system.The Lancet. Neurology, , Volume: 20, Issue:10, 2021
Parkinson's Disease: A Prionopathy?International journal of molecular sciences, , Jul-27, Volume: 22, Issue:15, 2021
The role of neuroimaging in Parkinson's disease.Journal of neurochemistry, , Volume: 159, Issue:4, 2021
Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson's Disease Models.Cells, , 07-05, Volume: 10, Issue:7, 2021
The intracellular milieu of Parkinson's disease patient brain cells modulates alpha-synuclein protein aggregation.Acta neuropathologica communications, , 09-16, Volume: 9, Issue:1, 2021
Toll-like receptor 4 deficiency facilitates α-synuclein propagation and neurodegeneration in a mouse model of prodromal Parkinson's disease.Parkinsonism & related disorders, , Volume: 91, 2021
Reelin Alleviates Mesenchymal Stem Cell Senescence and Reduces Pathological α-Synuclein Expression in an In Vitro Model of Parkinson's Disease.Genes, , 07-13, Volume: 12, Issue:7, 2021
Glucocerebrosidase dysfunction in neurodegenerative disease.Essays in biochemistry, , 12-22, Volume: 65, Issue:7, 2021
The AKT modulator A-443654 reduces α-synuclein expression and normalizes ER stress and autophagy.The Journal of biological chemistry, , Volume: 297, Issue:4, 2021
The binding of the small heat-shock protein αB-crystallin to fibrils of α-synuclein is driven by entropic forces.Proceedings of the National Academy of Sciences of the United States of America, , 09-21, Volume: 118, Issue:38, 2021
Pursuing Multiple Biomarkers for Early Idiopathic Parkinson's Disease Diagnosis.Molecular neurobiology, , Volume: 58, Issue:11, 2021
A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy.Neurobiology of disease, , Volume: 159, 2021
Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo.Nature communications, , 09-10, Volume: 12, Issue:1, 2021
Ellagic Acid Modulates Uninduced as well as Mutation and Metal-Induced Aggregation of α-Synuclein: Implications for Parkinson's Disease.ACS chemical neuroscience, , 10-06, Volume: 12, Issue:19, 2021
Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model.Molecular neurodegeneration, , 09-09, Volume: 16, Issue:1, 2021
Asymmetric Dopaminergic Dysfunction in Brain-First versus Body-First Parkinson's Disease Subtypes.Journal of Parkinson's disease, , Volume: 11, Issue:4, 2021
Novel Approaches Used to Examine and Control Neurogenesis in Parkinson's Disease.International journal of molecular sciences, , Sep-04, Volume: 22, Issue:17, 2021
Failure of Diphtheria Toxin Model to Induce Parkinson-Like Behavior in Mice.International journal of molecular sciences, , Aug-31, Volume: 22, Issue:17, 2021
[no title available]International journal of molecular sciences, , Aug-29, Volume: 22, Issue:17, 2021
A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies.Acta neuropathologica, , Volume: 142, Issue:3, 2021
Gut microbiota and metabolites of α-synuclein transgenic monkey models with early stage of Parkinson's disease.NPJ biofilms and microbiomes, , 09-02, Volume: 7, Issue:1, 2021
LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies.EMBO molecular medicine, , 09-07, Volume: 13, Issue:9, 2021
Cholesterol in Synaptic Vesicle Membranes Regulates the Vesicle-Binding, Function, and Aggregation of α-Synuclein.The journal of physical chemistry. B, , 10-14, Volume: 125, Issue:40, 2021
All-or-none amyloid disassembly via chaperone-triggered fibril unzipping favors clearance of α-synuclein toxic species.Proceedings of the National Academy of Sciences of the United States of America, , 09-07, Volume: 118, Issue:36, 2021
Alpha-Synuclein: The Interplay of Pathology, Neuroinflammation, and Environmental Factors in Parkinson's Disease.Neuro-degenerative diseases, , Volume: 20, Issue:2-3, 2020
Fibrillar α-synuclein toxicity depends on functional lysosomes.The Journal of biological chemistry, , 12-18, Volume: 295, Issue:51, 2020
Iron Dysregulation and Inflammagens Related to Oral and Gut Health Are Central to the Development of Parkinson's Disease.Biomolecules, , 12-29, Volume: 11, Issue:1, 2020
Evaluating the Effects of Grain of Isogenic Wheat Lines Differing in the Content of Anthocyanins in Mouse Models of Neurodegenerative Disorders.Nutrients, , Dec-18, Volume: 12, Issue:12, 2020
Validation and assessment of preanalytical factors of a fluorometric in vitro assay for glucocerebrosidase activity in human cerebrospinal fluid.Scientific reports, , 12-16, Volume: 10, Issue:1, 2020
Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing α-synuclein and immune activation of Parkinson's disease.Science advances, , Volume: 6, Issue:50, 2020
Isotope-reinforced polyunsaturated fatty acids improve Parkinson's disease-like phenotype in rats overexpressing α-synuclein.Acta neuropathologica communications, , 12-11, Volume: 8, Issue:1, 2020
Neuron-Astrocyte Interactions in Parkinson's Disease.Cells, , 12-07, Volume: 9, Issue:12, 2020
Enteric Glia at the Crossroads between Intestinal Immune System and Epithelial Barrier: Implications for Parkinson Disease.International journal of molecular sciences, , Dec-02, Volume: 21, Issue:23, 2020
Pathological Functions of LRRK2 in Parkinson's Disease.Cells, , 11-30, Volume: 9, Issue:12, 2020
Identification and Evaluation of Bisquinoline Scaffold as a New Candidate for α-Synuclein-PET Imaging.ACS chemical neuroscience, , 12-16, Volume: 11, Issue:24, 2020
Parkinson's disease and translational research.Translational neurodegeneration, , 12-01, Volume: 9, Issue:1, 2020
Novel antibodies detect additional α-synuclein pathology in synucleinopathies: potential development for immunotherapy.Alzheimer's research & therapy, , 11-30, Volume: 12, Issue:1, 2020
Effect of Ionic Strength on Thioflavin-T Affinity to Amyloid Fibrils and Its Fluorescence Intensity.International journal of molecular sciences, , Nov-24, Volume: 21, Issue:23, 2020
Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war.Nature communications, , 11-27, Volume: 11, Issue:1, 2020
Plasma Total α-Synuclein and Neurofilament Light Chain: Clinical Validation for Discriminating Parkinson's Disease from Normal Control.Dementia and geriatric cognitive disorders, , Volume: 49, Issue:4, 2020
MRI-visible perivascular spaces are associated with cerebrospinal fluid biomarkers in Parkinson's disease.Aging, , 11-25, Volume: 12, Issue:24, 2020
Ractopamine residue in meat might protect people from Parkinson disease.Medical hypotheses, , Volume: 145, 2020
Preferential microglial activation associated with pathological alpha synuclein transmission.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, , Volume: 81, 2020
CMT-3 targets different α-synuclein aggregates mitigating their toxic and inflammogenic effects.Scientific reports, , 11-20, Volume: 10, Issue:1, 2020
Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease.Acta neuropathologica communications, , 11-19, Volume: 8, Issue:1, 2020
Alpha-Synuclein in the Gastrointestinal Tract as a Potential Biomarker for Early Detection of Parkinson's Disease.International journal of molecular sciences, , Nov-17, Volume: 21, Issue:22, 2020
The Role of α-Synuclein Oligomers in Parkinson's Disease.International journal of molecular sciences, , Nov-17, Volume: 21, Issue:22, 2020
Megadalton-sized Dityrosine Aggregates of α-Synuclein Retain High Degrees of Structural Disorder and Internal Dynamics.Journal of molecular biology, , 12-04, Volume: 432, Issue:24, 2020
Effects of Grape Polyphenols on the Life Span and Neuroinflammatory Alterations Related to Neurodegenerative Parkinson Disease-Like Disturbances in Mice.Molecules (Basel, Switzerland), , Nov-16, Volume: 25, Issue:22, 2020
Complex Interaction between Resident Microbiota and Misfolded Proteins: Role in Neuroinflammation and Neurodegeneration.Cells, , 11-13, Volume: 9, Issue:11, 2020
Modeling Parkinson's Disease Neuropathology and Symptoms by Intranigral Inoculation of Preformed Human α-Synuclein Oligomers.International journal of molecular sciences, , Nov-12, Volume: 21, Issue:22, 2020
Gut Microbiota Approach-A New Strategy to Treat Parkinson's Disease.Frontiers in cellular and infection microbiology, , Volume: 10, 2020
The Library Derived 4554W Peptide Inhibits Primary Nucleation of α-Synuclein.Journal of molecular biology, , 12-04, Volume: 432, Issue:24, 2020
Epigallocatechin Gallate Destabilizes α-Synuclein Fibril by Disrupting the E46-K80 Salt-Bridge and Inter-protofibril Interface.ACS chemical neuroscience, , 12-16, Volume: 11, Issue:24, 2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disease.International journal of molecular sciences, , Nov-10, Volume: 21, Issue:22, 2020
Molecular dissection of amyloid disaggregation by human HSP70.Nature, , Volume: 587, Issue:7834, 2020
Amyloid-like oligomerization of AIMP2 contributes to α-synuclein interaction and Lewy-like inclusion.Science translational medicine, , 11-11, Volume: 12, Issue:569, 2020
Determinants of seeding and spreading of α-synuclein pathology in the brain.Science advances, , Volume: 6, Issue:46, 2020
Pathological findings in a patient with alpha-synuclein p.A53T and familial Parkinson's disease.Parkinsonism & related disorders, , Volume: 81, 2020
Negative α-synuclein pathology in the submandibular gland of patients carrying PRKN pathogenic variants.Parkinsonism & related disorders, , Volume: 81, 2020
Prolyl oligopeptidase inhibition by KYP-2407 increases alpha-synuclein fibril degradation in neuron-like cells.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 131, 2020
The Emerging Role of the Lysosome in Parkinson's Disease.Cells, , 11-02, Volume: 9, Issue:11, 2020
Unraveling the NaCl Concentration Effect on the First Stages of α-Synuclein Aggregation.Biomacromolecules, , 12-14, Volume: 21, Issue:12, 2020
Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy.Cells, , 10-29, Volume: 9, Issue:11, 2020
Parkinson's disease is an autoimmune disease: A reappraisal.Autoimmunity reviews, , Volume: 19, Issue:12, 2020
Multiplicity of α-Synuclein Aggregated Species and Their Possible Roles in Disease.International journal of molecular sciences, , Oct-28, Volume: 21, Issue:21, 2020
Apitherapy for Parkinson's Disease: A Focus on the Effects of Propolis and Royal Jelly.Oxidative medicine and cellular longevity, , Volume: 2020, 2020
Korean Red Ginseng Regulates Intestinal Tight Junction and Inflammation in the Colon of a Parkinson's Disease Mouse Model.Journal of medicinal food, , Volume: 23, Issue:12, 2020
Impaired metabolic brain networks associated with neurotransmission systems in the α-synuclein spectrum.Parkinsonism & related disorders, , Volume: 81, 2020
CD8 T cell nigral infiltration precedes synucleinopathy in early stages of Parkinson's disease.Brain : a journal of neurology, , 12-01, Volume: 143, Issue:12, 2020
Fast kinetics of environmentally induced α-synuclein aggregation mediated by structural alteration in NAC region and result in structure dependent cytotoxicity.Scientific reports, , 10-27, Volume: 10, Issue:1, 2020
Alpha-Synuclein in Alcohol Use Disorder, Connections with Parkinson's Disease and Potential Therapeutic Role of 5' Untranslated Region-Directed Small Molecules.Biomolecules, , 10-21, Volume: 10, Issue:10, 2020
Stress-induced p53 drives BAG5 cochaperone expression to control α-synuclein aggregation in Parkinson's disease.Aging, , 10-21, Volume: 12, Issue:20, 2020
[no title available]Aging, , 10-20, Volume: 12, Issue:20, 2020
Valeric Acid Protects Dopaminergic Neurons by Suppressing Oxidative Stress, Neuroinflammation and Modulating Autophagy Pathways.International journal of molecular sciences, , Oct-16, Volume: 21, Issue:20, 2020
Rapid Structural, Kinetic, and Immunochemical Analysis of Alpha-Synuclein Oligomers in Solution.Nano letters, , 11-11, Volume: 20, Issue:11, 2020
Cell type-specific lipid storage changes in Parkinson's disease patient brains are recapitulated by experimental glycolipid disturbance.Proceedings of the National Academy of Sciences of the United States of America, , 11-03, Volume: 117, Issue:44, 2020
Developmental deficits and early signs of neurodegeneration revealed by PD patient derived dopamine neurons.Stem cell research, , Volume: 49, 2020
Comparison of 123I-MIBG scintigraphy and phosphorylated α-synuclein skin deposits in synucleinopathies.Parkinsonism & related disorders, , Volume: 81, 2020
Modulation of α-Synuclein Fibrillation by Ultrasmall and Biocompatible Gold Nanoclusters.ACS chemical neuroscience, , 10-21, Volume: 11, Issue:20, 2020
Orthostatic hypotension as a core symptom in a Japanese family harboring SNCA duplication.Parkinsonism & related disorders, , Volume: 81, 2020
Endosomal dysfunction in iPSC-derived neural cells from Parkinson's disease patients with VPS35 D620N.Molecular brain, , 10-08, Volume: 13, Issue:1, 2020
Misfolded protein propagation in an integrated computational model of structural network and LRRK2 gene expression.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, , Volume: 2020, 2020
Alpha-Synuclein Protofibrils in Cerebrospinal Fluid: A Potential Biomarker for Parkinson's Disease.Journal of Parkinson's disease, , Volume: 10, Issue:4, 2020
Microglia modulate neurodegeneration in Alzheimer's and Parkinson's diseases.Science (New York, N.Y.), , 10-02, Volume: 370, Issue:6512, 2020
The Down-Regulation of Clusterin Expression Enhances the αSynuclein Aggregation Process.International journal of molecular sciences, , Sep-29, Volume: 21, Issue:19, 2020
Tau knockout exacerbates degeneration of parvalbumin-positive neurons in substantia nigra pars reticulata in Parkinson's disease-related α-synuclein A53T mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 34, Issue:9, 2020
Toxic Metamorphosis-How Changes from Lysosomal to Cytosolic pH Modify the Alpha-Synuclein Aggregation Pattern.Biomacromolecules, , 12-14, Volume: 21, Issue:12, 2020
CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease.Nature communications, , 09-28, Volume: 11, Issue:1, 2020
Graphene-Based Nanoparticles as Potential Treatment Options for Parkinson's Disease: A Molecular Dynamics Study.International journal of nanomedicine, , Volume: 15, 2020
Pathogenic LRRK2 requires secondary factors to induce cellular toxicity.Bioscience reports, , 10-30, Volume: 40, Issue:10, 2020
The role of natural killer cells in Parkinson's disease.Experimental & molecular medicine, , Volume: 52, Issue:9, 2020
No enhanced (p-) α-synuclein deposition in gastrointestinal tissue of Parkinson's disease patients.Parkinsonism & related disorders, , Volume: 80, 2020
How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structNeurobiology of disease, , Volume: 146, 2020
Diphenyl triazine hybrids inhibit α-synuclein fibrillogenesis: Design, synthesis and in vitro efficacy studies.European journal of medicinal chemistry, , Dec-01, Volume: 207, 2020
Blinded RT-QuIC Analysis of α-Synuclein Biomarker in Skin Tissue From Parkinson's Disease Patients.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:12, 2020
The mechanistic role of alpha-synuclein in the nucleus: impaired nuclear function caused by familial Parkinson's disease SNCA mutations.Human molecular genetics, , 11-04, Volume: 29, Issue:18, 2020
Associations of sleep characteristics with alpha-synuclein in cerebrospinal fluid in older adults.Annals of clinical and translational neurology, , Volume: 7, Issue:10, 2020
Facile Impedimetric Analysis of Neuronal Exosome Markers in Parkinson's Disease Diagnostics.Analytical chemistry, , 10-20, Volume: 92, Issue:20, 2020
Metabolomics Fingerprint Induced by the Intranigral Inoculation of Exogenous Human Alpha-Synuclein Oligomers in a Rat Model of Parkinson's Disease.International journal of molecular sciences, , Sep-14, Volume: 21, Issue:18, 2020
Authors' replies to the comments of Koga et al. on "Movement disorders rounds: A case of missing pathology in a patient with LRRK2 Parkinson's disease".Parkinsonism & related disorders, , Volume: 79, 2020
Using High-Content Screening to Generate Single-Cell Gene-Corrected Patient-Derived iPS Clones Reveals Excess Alpha-Synuclein with Familial Parkinson's Disease Point Mutation A30P.Cells, , 09-10, Volume: 9, Issue:9, 2020
Squalamine Restores the Function of the Enteric Nervous System in Mouse Models of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 10, Issue:4, 2020
Rational design of small molecules able to inhibit α-synuclein amyloid aggregation for the treatment of Parkinson's disease.Journal of enzyme inhibition and medicinal chemistry, , Volume: 35, Issue:1, 2020
Phosphorylated Alpha-Synuclein Within Cutaneous Autonomic Nerves of Patients With Parkinson's Disease: The Implications of Sample Thickness on Results.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, , Volume: 68, Issue:10, 2020
Astrocytes in Parkinson's disease: from preclinical assays to in vivo imaging and therapeutic probes.Neurobiology of aging, , Volume: 95, 2020
Immunoproteasome is up-regulated in rotenone-induced Parkinson's disease rat model.Neuroscience letters, , 11-01, Volume: 738, 2020
Hippocampal subfield pathologic burden in Lewy body diseases vs. Alzheimer's disease.Neuropathology and applied neurobiology, , Volume: 46, Issue:7, 2020
A Phase 1 Randomized Trial of Specific Active α-Synuclein Immunotherapies PD01A and PD03A in Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:11, 2020
Metabolic alterations in Parkinson's disease astrocytes.Scientific reports, , 09-02, Volume: 10, Issue:1, 2020
Alpha-synuclein aggresomes inhibit ciliogenesis and multiple functions of the centrosome.Biology open, , 10-05, Volume: 9, Issue:10, 2020
Naphthoquinone-Dopamine Hybrids Inhibit α-Synuclein Aggregation, Disrupt Preformed Fibrils, and Attenuate Aggregate-Induced Toxicity.Chemistry (Weinheim an der Bergstrasse, Germany), , Dec-09, Volume: 26, Issue:69, 2020
Transgenic Mice Expressing Human α-Synuclein in Noradrenergic Neurons Develop Locus Ceruleus Pathology and Nonmotor Features of Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 09-23, Volume: 40, Issue:39, 2020
Defining an amyloid link Between Parkinson's disease and melanoma.Proceedings of the National Academy of Sciences of the United States of America, , 09-15, Volume: 117, Issue:37, 2020
Mangosteen Pericarp and Its Bioactive Xanthones: Potential Therapeutic Value in Alzheimer's Disease, Parkinson's Disease, and Depression with Pharmacokinetic and Safety Profiles.International journal of molecular sciences, , Aug-27, Volume: 21, Issue:17, 2020
Blood Flow as a Route for Bidirectional Propagation of Synucleinopathy in Parkinson's Disease?Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:10, 2020
Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons.Journal of visualized experiments : JoVE, , 08-16, Issue:162, 2020
Conjugal multiple system atrophy: Rethinking numbers of probability.Parkinsonism & related disorders, , Volume: 77, 2020
Effect of Disease-Associated P123H and V70M Mutations on β-Synuclein Fibrillation.ACS chemical neuroscience, , 09-16, Volume: 11, Issue:18, 2020
Brain-first versus body-first Parkinson's disease: a multimodal imaging case-control study.Brain : a journal of neurology, , 10-01, Volume: 143, Issue:10, 2020
Differential activity of glucocerebrosidase in neurons and astrocytes; implications for evaluating tissue homogenates derived from Parkinson's disease brains.Journal of the neurological sciences, , 11-15, Volume: 418, 2020
COVID-19 and selective vulnerability to Parkinson's disease.The Lancet. Neurology, , Volume: 19, Issue:9, 2020
Gut Microbiome Imbalance and Neuroinflammation: Impact of COVID-19 on Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:9, 2020
Cathepsin K is a potent disaggregase of α-synuclein fibrils.Biochemical and biophysical research communications, , 09-03, Volume: 529, Issue:4, 2020
Cofilin 1 promotes the aggregation and cell-to-cell transmission of α-synuclein in Parkinson's disease.Biochemical and biophysical research communications, , 09-03, Volume: 529, Issue:4, 2020
Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys.EBioMedicine, , Volume: 59, 2020
LRRK2 kinase inhibitors reduce alpha-synuclein in human neuronal cell lines with the G2019S mutation.Neurobiology of disease, , Volume: 144, 2020
T cell infiltration and upregulation of MHCII in microglia leads to accelerated neuronal loss in an α-synuclein rat model of Parkinson's disease.Journal of neuroinflammation, , Aug-15, Volume: 17, Issue:1, 2020
Generation of two iPS cell lines (HIHDNDi001-A and HIHDNDi001-B) from a Parkinson's disease patient carrying the heterozygous p.A30P mutation in SNCA.Stem cell research, , Volume: 48, 2020
Effect of kaempferol on the transgenic Drosophila model of Parkinson's disease.Scientific reports, , 08-14, Volume: 10, Issue:1, 2020
The effect of copy number on α-synuclein's toxicity and its protective role in Bax-induced apoptosis, in yeast.Bioscience reports, , 09-30, Volume: 40, Issue:9, 2020
Polypeptides derived from α-Synuclein binding partners to prevent α-Synuclein fibrils interaction with and take-up by cells.PloS one, , Volume: 15, Issue:8, 2020
Neuroprotection of Rotenone-Induced Parkinsonism by Ursolic Acid in PD Mouse Model.CNS & neurological disorders drug targets, , Volume: 19, Issue:7, 2020
Real-Time Characterization of Cell Membrane Disruption by α-Synuclein Oligomers in Live SH-SY5Y Neuroblastoma Cells.ACS chemical neuroscience, , 09-02, Volume: 11, Issue:17, 2020
Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding.ACS chemical biology, , 08-21, Volume: 15, Issue:8, 2020
Discoidin Domain Receptor 1 is a therapeutic target for neurodegenerative diseases.Human molecular genetics, , 10-10, Volume: 29, Issue:17, 2020
Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity.Acta neuropathologica communications, , 08-06, Volume: 8, Issue:1, 2020
Therapeutic innovation in Parkinson's disease: a 2020 update on disease-modifying approaches.Expert review of neurotherapeutics, , Volume: 20, Issue:10, 2020
Iron promotes the clearance of α-synuclein: An Editorial for 'H63D variant of the homeostatic iron regulator (HFE) gene alters α-synuclein expression, aggregation, and toxicity" on page 177.Journal of neurochemistry, , Volume: 155, Issue:2, 2020
Where and how alpha-synuclein pathology spreads in Parkinson's disease.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 40, Issue:5, 2020
In vivo distribution of α-synuclein in multiple tissues and biofluids in Parkinson disease.Neurology, , 09-01, Volume: 95, Issue:9, 2020
Parkinson's disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EM.Proceedings of the National Academy of Sciences of the United States of America, , 08-18, Volume: 117, Issue:33, 2020
Alleviating toxic α-Synuclein accumulation by membrane depolarization: evidence from an in vitro model of Parkinson's disease.Molecular brain, , 07-31, Volume: 13, Issue:1, 2020
Microglia and astrocyte dysfunction in parkinson's disease.Neurobiology of disease, , Volume: 144, 2020
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.Scientific reports, , 07-30, Volume: 10, Issue:1, 2020
Somatic mutations in neurodegeneration: An update.Neurobiology of disease, , Volume: 144, 2020
Role of Tyr-39 for the Structural Features of α-Synuclein and for the Interaction with a Strong Modulator of Its Amyloid Assembly.International journal of molecular sciences, , Jul-17, Volume: 21, Issue:14, 2020
Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor.International journal of molecular sciences, , Jul-22, Volume: 21, Issue:15, 2020
Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression.Aging, , 07-24, Volume: 12, Issue:14, 2020
The hot sites of α-synuclein in amyloid fibril formation.Scientific reports, , 07-22, Volume: 10, Issue:1, 2020
Systemic Synuclein Sampling Study toward a Parkinson disease biomarker: Final results?Neurology, , 09-01, Volume: 95, Issue:9, 2020
α-Synuclein aggregation and transmission in Parkinson's disease: a link to mitochondria and lysosome.Science China. Life sciences, , Volume: 63, Issue:12, 2020
Classification of α-synuclein-induced changes in the AAV α-synuclein rat model of Parkinson's disease using electrophysiological measurements of visual processing.Scientific reports, , 07-17, Volume: 10, Issue:1, 2020
Prolongation of metallothionein induction combats Aß and α-synuclein toxicity in aged transgenic Caenorhabditis elegans.Scientific reports, , 07-16, Volume: 10, Issue:1, 2020
Evaluating the Role of SNCA, LRRK2, and GBA in Chinese Patients With Early-Onset Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:11, 2020
Lysosomal Storage Disorders Shed Light on Lysosomal Dysfunction in Parkinson's Disease.International journal of molecular sciences, , Jul-14, Volume: 21, Issue:14, 2020
Interaction of Alpha-Synuclein and Its Mutants with Rigid Lipid Vesicle Mimics of Varying Surface Curvature.ACS nano, , 08-25, Volume: 14, Issue:8, 2020
Autophagy and Parkinson's Disease.Advances in experimental medicine and biology, , Volume: 1207, 2020
Genetic Variation in Complex Traits in Transgenic α-Synuclein Strains of Genes, , 07-11, Volume: 11, Issue:7, 2020
SNPs in SNCA, MCCC1, DLG2, GBF1 and MBNL2 are associated with Parkinson's disease in southern Chinese population.Journal of cellular and molecular medicine, , Volume: 24, Issue:15, 2020
In silico drug repositioning of FDA-approved drugs to predict new inhibitors for alpha-synuclein aggregation.Computational biology and chemistry, , Volume: 88, 2020
Nano-imaging trace elements at organelle levels in substantia nigra overexpressing α-synuclein to model Parkinson's disease.Communications biology, , 07-09, Volume: 3, Issue:1, 2020
[Relationship between Drug Metabolism and Intestinal Microbiota in Parkinson's Disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:7, 2020
Erythrocytic α-synuclein contained in microvesicles regulates astrocytic glutamate homeostasis: a new perspective on Parkinson's disease pathogenesis.Acta neuropathologica communications, , 07-08, Volume: 8, Issue:1, 2020
Characterization of a pathogenic variant in GBA for Parkinson's disease with mild cognitive impairment patients.Molecular brain, , 07-08, Volume: 13, Issue:1, 2020
Caffeine: An Overview of Its Beneficial Effects in Experimental Models and Clinical Trials of Parkinson's Disease.International journal of molecular sciences, , Jul-04, Volume: 21, Issue:13, 2020
Copper and iron ions accelerate the prion-like propagation of α-synuclein: A vicious cycle in Parkinson's disease.International journal of biological macromolecules, , Nov-15, Volume: 163, 2020
Parkinson's disease a futile entangle of Mankind's credence on an herbal remedy: A review.Life sciences, , Sep-15, Volume: 257, 2020
Understanding the Pathogenesis Involved in Parkinson's Disease and Potential Therapeutic Treatment Strategies.Central nervous system agents in medicinal chemistry, , Volume: 20, Issue:2, 2020
Phase II Dose Selection for Alpha Synuclein-Targeting Antibody Cinpanemab (BIIB054) Based on Target Protein Binding Levels in the Brain.CPT: pharmacometrics & systems pharmacology, , Volume: 9, Issue:9, 2020
Enhancing the Activity of Glucocerebrosidase as a Treatment for Parkinson Disease.CNS drugs, , Volume: 34, Issue:9, 2020
Small-molecule inhibitors of α-synuclein for the treatment of Parkinson's disease: a patent landscape.Pharmaceutical patent analyst, , Volume: 9, Issue:3, 2020
Eye lens crystallin proteins inhibit the autocatalytic amyloid amplification nature of mature α-synuclein fibrils.PloS one, , Volume: 15, Issue:6, 2020
Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease.The Journal of clinical investigation, , 08-03, Volume: 130, Issue:8, 2020
Structural brain changes in Ser129-phosphorylated alpha-synuclein rats based on voxel-based morphometry.Behavioural brain research, , 09-01, Volume: 393, 2020
General Aggregation-Induced Emission Probes for Amyloid Inhibitors with Dual Inhibition Capacity against Amyloid β-Protein and α-Synuclein.ACS applied materials & interfaces, , Jul-15, Volume: 12, Issue:28, 2020
Dual Targeting of Monomeric Tau and α-Synuclein Aggregation: A New Multitarget Therapeutic Strategy for Neurodegeneration.ACS chemical neuroscience, , 07-15, Volume: 11, Issue:14, 2020
Fasudil Promotes α-Synuclein Clearance in an AAV-Mediated α-Synuclein Rat Model of Parkinson's Disease by Autophagy Activation.Journal of Parkinson's disease, , Volume: 10, Issue:3, 2020
Safety and immunogenicity of the α-synuclein active immunotherapeutic PD01A in patients with Parkinson's disease: a randomised, single-blinded, phase 1 trial.The Lancet. Neurology, , Volume: 19, Issue:7, 2020
Application of yeast to studying amyloid and prion diseases.Advances in genetics, , Volume: 105, 2020
Skin Biopsy May Help to Distinguish Multiple System Atrophy-Parkinsonism from Parkinson's Disease With Orthostatic Hypotension.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:9, 2020
Alpha-Synuclein Oligomers and Neurofilament Light Chain in Spinal Fluid Differentiate Multiple System Atrophy from Lewy Body Synucleinopathies.Annals of neurology, , Volume: 88, Issue:3, 2020
Timing Is Everything: The T-Cell Response to α-Synuclein Is Maximal in Early Parkinson's.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:7, 2020
Novel Furan-2-yl-1ACS chemical neuroscience, , 08-05, Volume: 11, Issue:15, 2020
Crosstalk Between Alpha-Synuclein and Other Human and Non-Human Amyloidogenic Proteins: Consequences for Amyloid Formation in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 10, Issue:3, 2020
Alpha-Synuclein Dopaminylation Presented in Plasma of Both Healthy Subjects and Parkinson's Disease Patients.Proteomics. Clinical applications, , Volume: 14, Issue:5, 2020
Oxidized nicotinamide adenine dinucleotide-dependent mitochondrial deacetylase sirtuin-3 as a potential therapeutic target of Parkinson's disease.Ageing research reviews, , Volume: 62, 2020
A Longitudinal Skin Biopsy Study of Phosphorylated Alpha-Synuclein in a Patient With Parkinson Disease and Orthostatic Hypotension.Journal of neuropathology and experimental neurology, , 07-01, Volume: 79, Issue:7, 2020
The Possible Protective Role of α-Synuclein Against Severe Acute Respiratory Syndrome Coronavirus 2 Infections in Patients With Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:8, 2020
α-Synuclein aggregation nucleates through liquid-liquid phase separation.Nature chemistry, , Volume: 12, Issue:8, 2020
Single-vesicle imaging reveals lipid-selective and stepwise membrane disruption by monomeric α-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , 06-23, Volume: 117, Issue:25, 2020
Distinct residual and disordered structures of alpha-synuclein analyzed by amide-proton exchange and NMR signal intensity.Biochimica et biophysica acta. Proteins and proteomics, , Volume: 1868, Issue:9, 2020
Novel drug delivery systems of β2 adrenoreceptor agonists to suppress SNCA gene expression and mitochondrial oxidative stress in Parkinson's disease management.Expert opinion on drug delivery, , Volume: 17, Issue:8, 2020
Intracellular delivery of Parkin rescues neurons from accumulation of damaged mitochondria and pathological α-synuclein.Science advances, , Volume: 6, Issue:18, 2020
Biophysical studies of protein misfolding and aggregation in Quarterly reviews of biophysics, , 06-04, Volume: 49, 2020
Healthspan Enhancement by Olive Polyphenols in International journal of molecular sciences, , May-29, Volume: 21, Issue:11, 2020
Interaction between SNCA gene polymorphisms and T2DM with Parkinson's disease.Acta neurologica Scandinavica, , Volume: 142, Issue:5, 2020
Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease.Aging cell, , Volume: 19, Issue:6, 2020
Improvement of Impaired Motor Functions by Human Dental Exfoliated Deciduous Teeth Stem Cell-Derived Factors in a Rat Model of Parkinson's Disease.International journal of molecular sciences, , May-27, Volume: 21, Issue:11, 2020
A novel multi-marker discovery approach identifies new serum biomarkers for Parkinson's disease in older people: an EXosomes in PArkiNson Disease (EXPAND) ancillary study.GeroScience, , Volume: 42, Issue:5, 2020
Parkinson's disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure.Nature communications, , 05-26, Volume: 11, Issue:1, 2020
Anti-aggregation Effects of Phenolic Compounds on α-synuclein.Molecules (Basel, Switzerland), , May-24, Volume: 25, Issue:10, 2020
Alteration of the Conformational Dynamics of a DNA Hairpin by α-Synuclein in the Presence of Aqueous Two-Phase Systems.Chemistry (Weinheim an der Bergstrasse, Germany), , Aug-26, Volume: 26, Issue:48, 2020
Increased alpha-synuclein tear fluid levels in patients with Parkinson's disease.Scientific reports, , 05-22, Volume: 10, Issue:1, 2020
Detection and Assessment of α-Synuclein Oligomers in the Urine of Parkinson's Disease Patients.Journal of Parkinson's disease, , Volume: 10, Issue:3, 2020
SNCA Hypomethylation in Rapid Eye Movement Sleep Behavior Disorder Is a Potential Biomarker for Parkinson's Disease.Journal of Parkinson's disease, , Volume: 10, Issue:3, 2020
Modelling cognitive deficits in Parkinson's disease: Is CA2 a gateway for hippocampal synucleinopathy?Experimental neurology, , Volume: 330, 2020
Reply: ARSA gene variants and Parkinson's disease.Brain : a journal of neurology, , 06-01, Volume: 143, Issue:6, 2020
ARSA gene variants and Parkinson's disease.Brain : a journal of neurology, , 06-01, Volume: 143, Issue:6, 2020
Simple and Complex Sugars in Parkinson's Disease: a Bittersweet Taste.Molecular neurobiology, , Volume: 57, Issue:7, 2020
Reduced oligodendrocyte exosome secretion in multiple system atrophy involves SNARE dysfunction.Brain : a journal of neurology, , 06-01, Volume: 143, Issue:6, 2020
Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates.Science advances, , Volume: 6, Issue:20, 2020
Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity.Scientific reports, , 05-18, Volume: 10, Issue:1, 2020
Immunization therapies for Parkinson's disease: state of the art and considerations for future clinical trials.Expert opinion on investigational drugs, , Volume: 29, Issue:7, 2020
Generation of a human induced pluripotent stem cell line derived from a Parkinson's disease patient carrying SNCA duplication.Stem cell research, , Volume: 45, 2020
Cerebrospinal Fluid Cytokines and Neurodegeneration-Associated Proteins in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:6, 2020
A Novel Tool to Investigate the Early and Late Stages of α-Synuclein Aggregation.ACS chemical neuroscience, , 06-03, Volume: 11, Issue:11, 2020
Clinical characterization of patients with leucine-rich repeat kinase 2 genetic variants in Japan.Journal of human genetics, , Volume: 65, Issue:9, 2020
Structural analyses and force fields comparison for NACore (68-78) and SubNACore (69-77) fibril segments of Parkinson's disease.Journal of molecular modeling, , May-12, Volume: 26, Issue:6, 2020
Lipids: Key Players That Modulate α-Synuclein Toxicity and Neurodegeneration in Parkinson's Disease.International journal of molecular sciences, , May-07, Volume: 21, Issue:9, 2020
Glucocerebrosidase deficiency promotes release of α-synuclein fibrils from cultured neurons.Human molecular genetics, , 06-27, Volume: 29, Issue:10, 2020
Intramitochondrial proteostasis is directly coupled to α-synuclein and amyloid β1-42 pathologies.The Journal of biological chemistry, , 07-24, Volume: 295, Issue:30, 2020
Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates.Brain : a journal of neurology, , 05-01, Volume: 143, Issue:5, 2020
α-Synuclein Regulates Iron Homeostasis via Preventing Parkin-Mediated DMT1 Ubiquitylation in Parkinson's Disease Models.ACS chemical neuroscience, , 06-03, Volume: 11, Issue:11, 2020
CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson's disease: a study in LRRK2 mutation carriers.Translational neurodegeneration, , 05-06, Volume: 9, Issue:1, 2020
Chronic Systemic Exposure to Low-Dose Rotenone Induced Central and Peripheral Neuropathology and Motor Deficits in Mice: Reproducible Animal Model of Parkinson's Disease.International journal of molecular sciences, , May-04, Volume: 21, Issue:9, 2020
The dual role of c-src in cell-to-cell transmission of α-synuclein.EMBO reports, , 07-03, Volume: 21, Issue:7, 2020
Carboxy-terminal truncation and phosphorylation of α-synuclein elongates survival in a prion-like seeding mouse model of synucleinopathy.Neuroscience letters, , 07-27, Volume: 732, 2020
Variants in the Niemann-Pick type C gene NPC1 are not associated with Parkinson's disease.Neurobiology of aging, , Volume: 93, 2020
A myosin-7B-dependent endocytosis pathway mediates cellular entry of α-synuclein fibrils and polycation-bearing cargos.Proceedings of the National Academy of Sciences of the United States of America, , 05-19, Volume: 117, Issue:20, 2020
Alpha-Synuclein and LRRK2 in Synaptic Autophagy: Linking Early Dysfunction to Late-Stage Pathology in Parkinson's Disease.Cells, , 04-30, Volume: 9, Issue:5, 2020
Specific Knockdown of α-Synuclein by Peptide-Directed Proteasome Degradation Rescued Its Associated Neurotoxicity.Cell chemical biology, , 06-18, Volume: 27, Issue:6, 2020
Calbindin-DCellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , May-02, Volume: 54, Issue:3, 2020
A Master Regulator of α-Synuclein Aggregation.ACS chemical neuroscience, , 05-20, Volume: 11, Issue:10, 2020
Synj1 haploinsufficiency causes dopamine neuron vulnerability and alpha-synuclein accumulation in mice.Human molecular genetics, , 08-11, Volume: 29, Issue:14, 2020
The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson's disease, multiple system atrophy and dementia with Lewy bodies.Acta neuropathologica, , Volume: 139, Issue:6, 2020
Small vessel disease pathological changes in neurodegenerative and vascular dementias concomitant with autonomic dysfunction.Brain pathology (Zurich, Switzerland), , Volume: 30, Issue:1, 2020
Microglial exosomes facilitate α-synuclein transmission in Parkinson's disease.Brain : a journal of neurology, , 05-01, Volume: 143, Issue:5, 2020
Enhanced Susceptibility of PINK1 Knockout Rats to α-Synuclein Fibrils.Neuroscience, , 06-15, Volume: 437, 2020
Polymorphic α-Synuclein Strains Modified by Dopamine and Docosahexaenoic Acid Interact Differentially with Tau Protein.Molecular neurobiology, , Volume: 57, Issue:6, 2020
S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson's disease.PloS one, , Volume: 15, Issue:4, 2020
Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation.Cell death and differentiation, , Volume: 27, Issue:10, 2020
Unilateral intranigral administration of β-sitosterol β-D-glucoside triggers pathological α-synuclein spreading and bilateral nigrostriatal dopaminergic neurodegeneration in the rat.Acta neuropathologica communications, , 04-22, Volume: 8, Issue:1, 2020
The role of alpha-synuclein as ferrireductase in neurodegeneration associated with Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 127, Issue:5, 2020
α-synuclein inclusions are abundant in non-neuronal cells in the anterior olfactory nucleus of the Parkinson's disease olfactory bulb.Scientific reports, , 04-21, Volume: 10, Issue:1, 2020
Analysis of Protein Conformational Strains-A Key for New Diagnostic Methods of Human Diseases.International journal of molecular sciences, , Apr-17, Volume: 21, Issue:8, 2020
α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson's disease.Nature communications, , 04-20, Volume: 11, Issue:1, 2020
α-Synucleinopathy associated c-Abl activation causes p53-dependent autophagy impairment.Molecular neurodegeneration, , 04-16, Volume: 15, Issue:1, 2020
A novel, label-free liquid crystal biosensor for Parkinson's disease related alpha-synuclein.Chemical communications (Cambridge, England), , May-19, Volume: 56, Issue:40, 2020
Structural basis of the interplay between α-synuclein and Tau in regulating pathological amyloid aggregation.The Journal of biological chemistry, , 05-22, Volume: 295, Issue:21, 2020
Chemical Chaperones as Novel Drugs for Parkinson's Disease.Trends in molecular medicine, , Volume: 26, Issue:4, 2020
Healthspan Maintenance and Prevention of Parkinson's-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in International journal of molecular sciences, , Apr-08, Volume: 21, Issue:7, 2020
The Interplay Between Proteostasis Systems and Parkinson's Disease.Advances in experimental medicine and biology, , Volume: 1233, 2020
Novel biomarkers for the evaluation of aging-induced proteinopathies.Biogerontology, , Volume: 21, Issue:5, 2020
Noncanonical Roles of hNeural plasticity, , Volume: 2020, 2020
Inhibition of HDAC6 activity protects dopaminergic neurons from alpha-synuclein toxicity.Scientific reports, , 04-08, Volume: 10, Issue:1, 2020
Biological links between traumatic brain injury and Parkinson's disease.Acta neuropathologica communications, , 04-07, Volume: 8, Issue:1, 2020
[no title available]Journal of integrative neuroscience, , Mar-30, Volume: 19, Issue:1, 2020
Tianma Gouteng granules decreases the susceptibility of Parkinson's disease by inhibiting ALOX15-mediated lipid peroxidation.Journal of ethnopharmacology, , Jun-28, Volume: 256, 2020
The value of cerebrospinal fluid α-synuclein and the tau/α-synuclein ratio for diagnosis of neurodegenerative disorders with Lewy pathology.European journal of neurology, , Volume: 27, Issue:1, 2020
Selective neuronal vulnerability in Parkinson's disease.Progress in brain research, , Volume: 252, 2020
Novel approaches to counter protein aggregation pathology in Parkinson's disease.Progress in brain research, , Volume: 252, 2020
The gut microbiome in Parkinson's disease: A culprit or a bystander?Progress in brain research, , Volume: 252, 2020
Pathways of protein synthesis and degradation in PD pathogenesis.Progress in brain research, , Volume: 252, 2020
The Promise and Challenges of Developing miRNA-Based Therapeutics for Parkinson's Disease.Cells, , 03-31, Volume: 9, Issue:4, 2020
A common polymorphism in Journal of neurology, neurosurgery, and psychiatry, , Volume: 91, Issue:6, 2020
Long Noncoding RNA POU3F3 and α-Synuclein in Plasma L1CAM Exosomes Combined with β-Glucocerebrosidase Activity: Potential Predictors of Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 17, Issue:3, 2020
Peripheral alpha-synuclein levels in patients with genetic and non-genetic forms of Parkinson's disease.Parkinsonism & related disorders, , Volume: 73, 2020
Role of Alcohol Drinking in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis.International journal of molecular sciences, , Mar-27, Volume: 21, Issue:7, 2020
A role for α-Synuclein in axon growth and its implications in corticostriatal glutamatergic plasticity in Parkinson's disease.Molecular neurodegeneration, , 03-30, Volume: 15, Issue:1, 2020
Structure of a Parkinson's Disease-Involved α-Synuclein Peptide Is Modulated by Membrane Composition and Physical State.The journal of physical chemistry. B, , 04-30, Volume: 124, Issue:17, 2020
Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice.Neurobiology of aging, , Volume: 91, 2020
Biofluid Biomarkers in Parkinson's Disease: Clarity Amid Controversy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:7, 2020
What and How Can Physical Activity Prevention Function on Parkinson's Disease?Oxidative medicine and cellular longevity, , Volume: 2020, 2020
The function of bacterial HtrA is evolutionally conserved in mammalian HtrA2/Omi.Scientific reports, , 03-24, Volume: 10, Issue:1, 2020
Long-term post-mortem studies following neurturin gene therapy in patients with advanced Parkinson's disease.Brain : a journal of neurology, , 03-01, Volume: 143, Issue:3, 2020
Protein transmission in neurodegenerative disease.Nature reviews. Neurology, , Volume: 16, Issue:4, 2020
Lipids as the key to understanding α-synuclein behaviour in Parkinson disease.Nature reviews. Molecular cell biology, , Volume: 21, Issue:7, 2020
Cryo-EM structure of full-length α-synuclein amyloid fibril with Parkinson's disease familial A53T mutation.Cell research, , Volume: 30, Issue:4, 2020
Disease-Specific Strains of α-Synuclein in Multiple System Atrophy and Parkinson's Disease: But Why?Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:5, 2020
Conjugal multiple system atrophy: Be wary of implicating transmissibility.Parkinsonism & related disorders, , Volume: 75, 2020
Aggregation and Cellular Toxicity of Pathogenic or Non-pathogenic Proteins.Scientific reports, , 03-20, Volume: 10, Issue:1, 2020
Insulin Resistance Promotes Parkinson's Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling.Cells, , 03-17, Volume: 9, Issue:3, 2020
Potential sources of interference with the highly sensitive detection and quantification of alpha-synuclein seeds by qRT-QuIC.FEBS open bio, , Volume: 10, Issue:5, 2020
The Aggregation Conditions Define Whether EGCG is an Inhibitor or Enhancer of International journal of molecular sciences, , Mar-14, Volume: 21, Issue:6, 2020
Serum Uric Acid Level as a Biomarker in Idiopathic and Genetic (p.A53T Alpha-Synuclein Carriers) Parkinson's Disease: Data from the PPMI Study.Journal of Parkinson's disease, , Volume: 10, Issue:2, 2020
Downregulation of α-Synuclein Protein Levels by an Intracellular Single-Chain Antibody.Journal of Parkinson's disease, , Volume: 10, Issue:2, 2020
Advances in modelling alpha-synuclein-induced Parkinson's diseases in rodents: Virus-based models versus inoculation of exogenous preformed toxic species.Journal of neuroscience methods, , 05-15, Volume: 338, 2020
Mutated ATP10B increases Parkinson's disease risk by compromising lysosomal glucosylceramide export.Acta neuropathologica, , Volume: 139, Issue:6, 2020
Differential effects of CuBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, , Volume: 33, Issue:2-3, 2020
Autonomic dysfunction is associated with neuropsychological impairment in Lewy body disease.Journal of neurology, , Volume: 267, Issue:7, 2020
Salient Features of Monomeric Alpha-Synuclein Revealed by NMR Spectroscopy.Biomolecules, , 03-10, Volume: 10, Issue:3, 2020
Demonstration of brain region-specific neuronal vulnerability in human iPSC-based model of familial Parkinson's disease.Human molecular genetics, , 05-08, Volume: 29, Issue:7, 2020
The Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils.ACS nano, , 05-26, Volume: 14, Issue:5, 2020
A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function.Nature structural & molecular biology, , Volume: 27, Issue:3, 2020
A longitudinal study on α-synuclein in plasma neuronal exosomes as a biomarker for Parkinson's disease development and progression.European journal of neurology, , Volume: 27, Issue:6, 2020
Investigating the Effects of O-GlcNAc Modifications in Parkinson's Disease Using Semisynthetic α-Synuclein.Methods in molecular biology (Clifton, N.J.), , Volume: 2133, 2020
Initiation and propagation of α-synuclein aggregation in the nervous system.Molecular neurodegeneration, , 03-06, Volume: 15, Issue:1, 2020
Targeting α-synuclein for PD Therapeutics: A Pursuit on All Fronts.Biomolecules, , 03-03, Volume: 10, Issue:3, 2020
Novel fatty acid-binding protein 3 ligand inhibits dopaminergic neuronal death and improves motor and cognitive impairments in Parkinson's disease model mice.Pharmacology, biochemistry, and behavior, , Volume: 191, 2020
Genetic causes of PD: A pathway to disease modification.Neuropharmacology, , 06-15, Volume: 170, 2020
Methods for detecting toxic α-synuclein species as a biomarker for Parkinson's disease.Critical reviews in clinical laboratory sciences, , Volume: 57, Issue:5, 2020
α-Synuclein fibrillation products trigger the release of hexokinase I from mitochondria: Protection by curcumin, and possible role in pathogenesis of Parkinson's disease.Biochimica et biophysica acta. Biomembranes, , 06-01, Volume: 1862, Issue:6, 2020
New insights on the structure of alpha-synuclein fibrils using cryo-electron microscopy.Current opinion in neurobiology, , Volume: 61, 2020
The Link between Gut Dysbiosis and Neuroinflammation in Parkinson's Disease.Neuroscience, , 04-15, Volume: 432, 2020
Interaction of α-synuclein and Parkin in iron toxicity on SH-SY5Y cells: implications in the pathogenesis of Parkinson's disease.The Biochemical journal, , 03-27, Volume: 477, Issue:6, 2020
Choroid plexus volume is associated with levels of CSF proteins: relevance for Alzheimer's and Parkinson's disease.Neurobiology of aging, , Volume: 89, 2020
Glucocerebrosidase as a therapeutic target for Parkinson's disease.Expert opinion on therapeutic targets, , Volume: 24, Issue:4, 2020
Iron-mediated interaction of alpha synuclein with lipid raft model membranes.Nanoscale, , Apr-14, Volume: 12, Issue:14, 2020
Synthesis and characterization of high affinity fluorogenic α-synuclein probes.Chemical communications (Cambridge, England), , Mar-24, Volume: 56, Issue:24, 2020
A Curcumin Derivative Activates TFEB and Protects Against Parkinsonian Neurotoxicity International journal of molecular sciences, , Feb-22, Volume: 21, Issue:4, 2020
PET Radiopharmaceuticals for Alzheimer's Disease and Parkinson's Disease Diagnosis, the Current and Future Landscape.Molecules (Basel, Switzerland), , Feb-21, Volume: 25, Issue:4, 2020
Implications of the Gut Microbiome in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:6, 2020
Quantitative Profiling of Synuclein Species: Application to Transgenic Mouse Models of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 10, Issue:2, 2020
Role of α-Synuclein Regions in Nucleation and Elongation of Amyloid Fiber Assembly.ACS chemical neuroscience, , 03-18, Volume: 11, Issue:6, 2020
Novel 1-hydroxypyridin-2-one metal chelators prevent and rescue ubiquitin proteasomal-related neuronal injury in an in vitro model of Parkinson's disease.Archives of toxicology, , Volume: 94, Issue:3, 2020
The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration.Proceedings of the National Academy of Sciences of the United States of America, , 03-03, Volume: 117, Issue:9, 2020
The Properties of α-Synuclein Secondary Nuclei Are Dominated by the Solution Conditions Rather than the Seed Fibril Strain.ACS chemical neuroscience, , 03-18, Volume: 11, Issue:6, 2020
Chemoenzymatic Semisynthesis of Phosphorylated α-Synuclein Enables Identification of a Bidirectional Effect on Fibril Formation.ACS chemical biology, , 03-20, Volume: 15, Issue:3, 2020
Tears - more to them than meets the eye: why tears are a good source of biomarkers in Parkinson's disease.Biomarkers in medicine, , Volume: 14, Issue:2, 2020
Back and to the Future: From Neurotoxin-Induced to Human Parkinson's Disease Models.Current protocols in neuroscience, , Volume: 91, Issue:1, 2020
A new MAP-Rasagiline conjugate reduces α-synuclein inclusion formation in a cell model.Pharmacological reports : PR, , Volume: 72, Issue:2, 2020
Elevated Serum α-Synuclein Levels in Huntington's Disease Patients.Neuroscience, , 04-01, Volume: 431, 2020
Neurodegenerative diseases distinguished through protein-structure analysis.Nature, , Volume: 578, Issue:7794, 2020
Replication-Based Rearrangements Are a Common Mechanism for SNCA Duplication in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:5, 2020
Disentangling aggregation-prone proteins: a new method for isolating α-synuclein species: An Editorial Highlight for "A simple, versatile and robust centrifugation-based filtration protocol for the isolation and quantification of α-synuclein monomers, oliJournal of neurochemistry, , Volume: 153, Issue:1, 2020
[Emerging Disease-modifying Strategies Targeting α-synuclein in Parkinson's Disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:2, 2020
[α-Synuclein as Diagnostic Biomarker].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:2, 2020
[Perspective of α-synuclein and Familial Parkinson's Disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:2, 2020
[REM Sleep Behavior Disorder and α-synucleinopathy].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:2, 2020
Synergy between plasminogen activator inhibitor-1, α-synuclein, and neuroinflammation in Parkinson's disease.Medical hypotheses, , Volume: 138, 2020
Alpha-synuclein/synapsin III pathological interplay boosts the motor response to methylphenidate.Neurobiology of disease, , Volume: 138, 2020
Identification of potential natural neuroprotective molecules for Parkinson's disease by using chemoinformatics and molecular docking.Journal of molecular graphics & modelling, , Volume: 97, 2020
A Self-Assembled α-Synuclein Nanoscavenger for Parkinson's Disease.ACS nano, , 02-25, Volume: 14, Issue:2, 2020
Parkinson's disease and iron.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 127, Issue:2, 2020
Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy.Nature, , Volume: 578, Issue:7794, 2020
The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure.Proceedings of the National Academy of Sciences of the United States of America, , 02-18, Volume: 117, Issue:7, 2020
Copper Ions and Parkinson's Disease: Why Is Homeostasis So Relevant?Biomolecules, , 01-29, Volume: 10, Issue:2, 2020
Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson's disease.Brain, behavior, and immunity, , Volume: 87, 2020
Amyloid aggregates of the deubiquitinase OTUB1 are neurotoxic, suggesting that they contribute to the development of Parkinson's disease.The Journal of biological chemistry, , 03-13, Volume: 295, Issue:11, 2020
Co-Existence of tau and α-synuclein pathology in fetal graft tissue at autopsy: A case report.Parkinsonism & related disorders, , Volume: 71, 2020
In search of Parkinson's disease biomarkers - is the answer in our mouths? A systematic review of the literature on salivary biomarkers of Parkinson's disease.Neurologia i neurochirurgia polska, , Volume: 54, Issue:1, 2020
6-OH-BDE-47 exposure-induced Parkinson's disease pathology in Sprague Dawley rat.The Science of the total environment, , Apr-01, Volume: 711, 2020
Rasagiline and selegiline modulate mitochondrial homeostasis, intervene apoptosis system and mitigate α-synuclein cytotoxicity in disease-modifying therapy for Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 127, Issue:2, 2020
N-terminal acetylation mutants affect alpha-synuclein stability, protein levels and neuronal toxicity.Neurobiology of disease, , Volume: 137, 2020
The contribution of Parkin, PINK1 and DJ-1 genes to selective neuronal degeneration in Parkinson's disease.The European journal of neuroscience, , Volume: 52, Issue:4, 2020
iPSC modeling of young-onset Parkinson's disease reveals a molecular signature of disease and novel therapeutic candidates.Nature medicine, , Volume: 26, Issue:2, 2020
If not salivary alpha-synuclein, then what? A look at potential Parkinson's disease biomarkers.Expert review of molecular diagnostics, , Volume: 20, Issue:4, 2020
Immunotherapy for Parkinson's disease.Neurobiology of disease, , Volume: 137, 2020
Alterations in α-synuclein and PINK1 expression reduce neurite length and induce mitochondrial fission and Golgi fragmentation in midbrain neurons.Neuroscience letters, , 02-16, Volume: 720, 2020
Fine-Mapping of SNCA in Rapid Eye Movement Sleep Behavior Disorder and Overt Synucleinopathies.Annals of neurology, , Volume: 87, Issue:4, 2020
Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4.Journal of immunology (Baltimore, Md. : 1950), , 03-01, Volume: 204, Issue:5, 2020
The biochemical basis of interactions between Glucocerebrosidase and alpha-synuclein in GBA1 mutation carriers.Journal of neurochemistry, , Volume: 154, Issue:1, 2020
Dysregulated Interorganellar Crosstalk of Mitochondria in the Pathogenesis of Parkinson's Disease.Cells, , 01-17, Volume: 9, Issue:1, 2020
TGF-β/Smad3 Signalling Modulates GABA Neurotransmission: Implications in Parkinson's Disease.International journal of molecular sciences, , Jan-16, Volume: 21, Issue:2, 2020
Dysbiosis in Parkinson's disease might be triggered by certain antibiotics.Medical hypotheses, , Volume: 137, 2020
Generation of an induced pluripotent stem cell line (CSC-32) from a patient with Parkinson's disease carrying a heterozygous variation p.A53T in the SNCA gene.Stem cell research, , Volume: 43, 2020
Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans.Cell reports, , 01-14, Volume: 30, Issue:2, 2020
Scutellarin inhibits the uninduced and metal-induced aggregation of α-Synuclein and disaggregates preformed fibrils: implications for Parkinson's disease.The Biochemical journal, , 02-14, Volume: 477, Issue:3, 2020
Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway.Molecular neurodegeneration, , 01-13, Volume: 15, Issue:1, 2020
A simple, versatile and robust centrifugation-based filtration protocol for the isolation and quantification of α-synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in α-synuclein research.Journal of neurochemistry, , Volume: 153, Issue:1, 2020
Systemic activation of NLRP3 inflammasome and plasma α-synuclein levels are correlated with motor severity and progression in Parkinson's disease.Journal of neuroinflammation, , Jan-08, Volume: 17, Issue:1, 2020
Novel Therapeutics for the Treatment of Alzheimer's and Parkinson's Disease.Current pharmaceutical design, , Volume: 26, Issue:7, 2020
[Current Status and Future Prospects of Therapeutic Development of Parkinson's Disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:1, 2020
A new avenue for treating Parkinson's disease targeted at aggrephagy modulation and neuroinflammation: Insights from in vitro and animal studies.EBioMedicine, , Volume: 51, 2020
NK cells clear α-synuclein and the depletion of NK cells exacerbates synuclein pathology in a mouse model of α-synucleinopathy.Proceedings of the National Academy of Sciences of the United States of America, , 01-21, Volume: 117, Issue:3, 2020
Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult.Neuron, , 03-04, Volume: 105, Issue:5, 2020
Inhibition of synucleinopathic seeding by rationally designed inhibitors.eLife, , 01-02, Volume: 9, 2020
Correlation between Cellular Uptake and Cytotoxicity of Fragmented α-Synuclein Amyloid Fibrils Suggests Intracellular Basis for Toxicity.ACS chemical neuroscience, , 02-05, Volume: 11, Issue:3, 2020
p38 MAPK-DRP1 signaling is involved in mitochondrial dysfunction and cell death in mutant A53T α-synuclein model of Parkinson's disease.Toxicology and applied pharmacology, , 02-01, Volume: 388, 2020
The neuroprotective effect of fullerenols on a model of Parkinson's disease in Drosophila melanogaster.Biochemical and biophysical research communications, , 03-05, Volume: 523, Issue:2, 2020
Integrated Plasma and Neuroimaging Biomarkers Associated with Motor and Cognition Severity in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 10, Issue:1, 2020
Association between SNCA rs356220 polymorphism and Parkinson's disease: A meta-analysis.Neuroscience letters, , 01-19, Volume: 717, 2020
A multi-faceted genotoxic network of alpha-synuclein in the nucleus and mitochondria of dopaminergic neurons in Parkinson's disease: Emerging concepts and challenges.Progress in neurobiology, , Volume: 185, 2020
[no title available]ChemMedChem, , 03-05, Volume: 15, Issue:5, 2020
Reduced cerebral blood flow in an Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 40, Issue:12, 2020
Interactions between Soluble Species of β-Amyloid and α-Synuclein Promote Oligomerization while Inhibiting Fibrillization.Biochemistry, , 02-04, Volume: 59, Issue:4, 2020
The gut in Parkinson's disease: Bottom-up, top-down, or neither?Neurogastroenterology and motility, , Volume: 32, Issue:1, 2020
Global ubiquitome analysis of substantia nigra in doubly-mutant human alpha-synuclein transgenic mice.Behavioural brain research, , 02-17, Volume: 380, 2020
Behavioral defects associated with amygdala and cortical dysfunction in mice with seeded α-synuclein inclusions.Neurobiology of disease, , Volume: 134, 2020
Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease.Neurobiology of disease, , Volume: 136, 2020
α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson's disease model.Brain : a journal of neurology, , 01-01, Volume: 143, Issue:1, 2020
Ubiquitination Can Change the Structure of the α-Synuclein Amyloid Fiber in a Site Selective Fashion.The Journal of organic chemistry, , 02-07, Volume: 85, Issue:3, 2020
Parkinson's disease and the gastrointestinal microbiome.Journal of neurology, , Volume: 267, Issue:9, 2020
Salivary microR-153 and microR-223 Levels as Potential Diagnostic Biomarkers of Idiopathic Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:3, 2020
Circulating Brain-enriched MicroRNAs for detection and discrimination of idiopathic and genetic Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:3, 2020
Loss of fragile X mental retardation protein precedes Lewy pathology in Parkinson's disease.Acta neuropathologica, , Volume: 139, Issue:2, 2020
Mycobacterial immunomodulation and viral manipulation of neuronal copper efflux in the setting of sporadic Parkinson's disease: A multi - hit, outside - in hypothesis of its pathogenesis.Medical hypotheses, , Volume: 136, 2020
Dopamine D3 receptor: A neglected participant in Parkinson Disease pathogenesis and treatment?Ageing research reviews, , Volume: 57, 2020
Autophagy lysosomal pathway dysfunction in Parkinson's disease; evidence from human genetics.Parkinsonism & related disorders, , Volume: 73, 2020
GBA1 mutations: Prospects for exosomal biomarkers in α-synuclein pathologies.Molecular genetics and metabolism, , Volume: 129, Issue:2, 2020
Gold-nanourchin seeded single-walled carbon nanotube on voltammetry sensor for diagnosing neurogenerative Parkinson's disease.Analytica chimica acta, , Jan-15, Volume: 1094, 2020
α-Synuclein real-time quaking-induced conversion in the submandibular glands of Parkinson's disease patients.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:2, 2020
Association between alpha-synuclein (SNCA) rs11931074 variability and susceptibility to Parkinson's disease: an updated meta-analysis of 41,811 patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 41, Issue:2, 2020
Insight into the molecular mechanism underlying the inhibition of α-synuclein aggregation by hydroxytyrosol.Biochemical pharmacology, , Volume: 173, 2020
Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia.Brain : a journal of neurology, , 01-01, Volume: 143, Issue:1, 2020
O-GlcNAcylation of truncated NAC segment alters peptide-dependent effects on α-synuclein aggregation.Bioorganic chemistry, , Volume: 94, 2020
Doublecortin-like Kinase 1 Regulates α-Synuclein Levels and Toxicity.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 01-08, Volume: 40, Issue:2, 2020
3,4-Dihydroxyphenylacetaldehyde Is More Efficient than Dopamine in Oligomerizing and Quinonizing The Journal of pharmacology and experimental therapeutics, , Volume: 372, Issue:2, 2020
CSF or serum neurofilament light added to α-Synuclein panel discriminates Parkinson's from controls.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:2, 2020
Apoptosis signal regulating kinase 1 deletion mitigates α-synuclein pre-formed fibril propagation in mice.Neurobiology of aging, , Volume: 85, 2020
The vicious cycle between α-synuclein aggregation and autophagic-lysosomal dysfunction.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:1, 2020
Bioluminescence Imaging of Neuroinflammation in a Mouse Model of Parkinson's Disease.Methods in molecular biology (Clifton, N.J.), , Volume: 2081, 2020
Inflammasome and α-synuclein in Parkinson's disease: A cross-sectional study.Journal of neuroimmunology, , 01-15, Volume: 338, 2020
The good and bad of therapeutic strategies that directly target α-synuclein.IUBMB life, , Volume: 72, Issue:4, 2020
Systemic activation of Nrf2 pathway in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:1, 2020
Parkinson's Disease: Glucocerebrosidase 1 Mutation Severity Is Associated with CSF Alpha-Synuclein Profiles.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:3, 2020
A characterization of Gaucher iPS-derived astrocytes: Potential implications for Parkinson's disease.Neurobiology of disease, , Volume: 134, 2020
Initiation of Parkinson's disease from gut to brain by δ-secretase.Cell research, , Volume: 30, Issue:1, 2020
Biomarkers for Parkinson's Disease: How Good Are They?Neuroscience bulletin, , Volume: 36, Issue:2, 2020
Structurally distinct α-synuclein fibrils induce robust parkinsonian pathology.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:2, 2020
Glucocerebrosidase activity, cathepsin D and monomeric α-synuclein interactions in a stem cell derived neuronal model of a PD associated GBA1 mutation.Neurobiology of disease, , Volume: 134, 2020
Neural connectivity predicts spreading of alpha-synuclein pathology in fibril-injected mouse models: Involvement of retrograde and anterograde axonal propagation.Neurobiology of disease, , Volume: 134, 2020
Open questions on the nature of Parkinson's disease: from triggers to spreading pathology.Journal of medical genetics, , Volume: 57, Issue:2, 2020
Recuperative effect of metformin loaded polydopamine nanoformulation promoting EZH2 mediated proteasomal degradation of phospho-α-synuclein in Parkinson's disease model.Nanomedicine : nanotechnology, biology, and medicine, , Volume: 24, 2020
A sticky situation: Aberrant protein-protein interactions in Parkinson's disease.Seminars in cell & developmental biology, , Volume: 99, 2020
The heart of PD: Lewy body diseases as neurocardiologic disorders.Brain research, , 01-01, Volume: 1702, 2019
A Comparative Study of the Diagnostic Potential of Plasma and Erythrocytic α-Synuclein in Parkinson's Disease.Neuro-degenerative diseases, , Volume: 19, Issue:5-6, 2019
A Cleaning Crew: The Pursuit of Autophagy in Parkinson's Disease.ACS chemical neuroscience, , 09-18, Volume: 10, Issue:9, 2019
Deciphering the anti-Parkinson's activity of sulphated polysaccharides from Chlamydomonas reinhardtii on the α-Synuclein mutants A30P, A53T, E46K, E57K and E35K.Journal of biochemistry, , Dec-01, Volume: 166, Issue:6, 2019
Oxidative stress and α-synuclein conspire in vulnerable neurons to promote Parkinson's disease progression.The Journal of clinical investigation, , 08-05, Volume: 129, Issue:9, 2019
Effects of single and combined immunotherapy approach targeting amyloid β protein and α-synuclein in a dementia with Lewy bodies-like model.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 15, Issue:9, 2019
Autophagy activation promotes clearance of α-synuclein inclusions in fibril-seeded human neural cells.The Journal of biological chemistry, , 09-27, Volume: 294, Issue:39, 2019
Precision Medicine in Rapid Eye Movement Sleep Behavior Disorder.Sleep medicine clinics, , Volume: 14, Issue:3, 2019
TREM2 deficiency aggravates α-synuclein-induced neurodegeneration and neuroinflammation in Parkinson's disease models.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 33, Issue:11, 2019
Iron and other metals in the pathogenesis of Parkinson's disease: Toxic effects and possible detoxification.Journal of inorganic biochemistry, , Volume: 199, 2019
5-S-cysteinyl-dopamine, a neurotoxic endogenous metabolite of dopamine: Implications for Parkinson's disease.Neurochemistry international, , Volume: 129, 2019
Longitudinal analyses of cerebrospinal fluid α-Synuclein in prodromal and early Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:9, 2019
Regional transcriptional architecture of Parkinson's disease pathogenesis and network spread.Brain : a journal of neurology, , 10-01, Volume: 142, Issue:10, 2019
Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders.Scientific reports, , 07-29, Volume: 9, Issue:1, 2019
New therapeutic approaches to target alpha-synuclein in Parkinson's disease: The role of immunotherapy.International review of neurobiology, , Volume: 146, 2019
Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease.Annals of neurology, , Volume: 86, Issue:4, 2019
Alpha-synuclein structure and Parkinson's disease - lessons and emerging principles.Molecular neurodegeneration, , 07-22, Volume: 14, Issue:1, 2019
Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson's disease.Journal of neuroinflammation, , Jul-22, Volume: 16, Issue:1, 2019
Microbubble-facilitated ultrasound pulsation promotes direct α-synuclein gene delivery.Biochemical and biophysical research communications, , 09-10, Volume: 517, Issue:1, 2019
Association of rs356219 and rs3822086 polymorphisms with the risk of Parkinson's disease: A meta-analysis.Neuroscience letters, , 09-14, Volume: 709, 2019
Poly-ADP-ribose assisted protein localization resolves that DJ-1, but not LRRK2 or α-synuclein, is localized to the mitochondrial matrix.PloS one, , Volume: 14, Issue:7, 2019
Value of in vivo α-synuclein deposits in Parkinson's disease: A systematic review and meta-analysis.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:10, 2019
The relationship between inflammatory bowel disease and Parkinson's disease: true or fiction?Scandinavian journal of gastroenterology, , Volume: 54, Issue:7, 2019
Tetramethylpyrazine Analogue T-006 Promotes the Clearance of Alpha-synuclein by Enhancing Proteasome Activity in Parkinson's Disease Models.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 16, Issue:4, 2019
Arylsulfatase A, a genetic modifier of Parkinson's disease, is an α-synuclein chaperone.Brain : a journal of neurology, , 09-01, Volume: 142, Issue:9, 2019
New models show gut-brain transmission of Parkinson disease pathology.Nature reviews. Neurology, , Volume: 15, Issue:9, 2019
Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay.Journal of visualized experiments : JoVE, , 06-25, Issue:148, 2019
Exosomes from patients with Parkinson's disease are pathological in mice.Journal of molecular medicine (Berlin, Germany), , Volume: 97, Issue:9, 2019
Structural Insights into α-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations.Journal of molecular biology, , 09-06, Volume: 431, Issue:19, 2019
Can GBA1-Associated Parkinson Disease Be Modeled in the Mouse?Trends in neurosciences, , Volume: 42, Issue:9, 2019
Toll-like receptors and their therapeutic potential in Parkinson's disease and α-synucleinopathies.Brain, behavior, and immunity, , Volume: 81, 2019
α-synuclein-lipoprotein interactions and elevated ApoE level in cerebrospinal fluid from Parkinson's disease patients.Proceedings of the National Academy of Sciences of the United States of America, , 07-23, Volume: 116, Issue:30, 2019
Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies.Cell reports, , 07-02, Volume: 28, Issue:1, 2019
The physiological role of α-synuclein and its relationship to Parkinson's Disease.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
The A30P α-synuclein mutation decreases subventricular zone proliferation.Human molecular genetics, , 07-15, Volume: 28, Issue:14, 2019
Parkinson's disease biomarkers based on α-synuclein.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Functionalization of the TMEM175 p.M393T variant as a risk factor for Parkinson disease.Human molecular genetics, , 10-01, Volume: 28, Issue:19, 2019
[Prion-like Propagation of Pathological α-Synuclein in Vivo].Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, , Volume: 139, Issue:7, 2019
Neuronal microtubules and proteins linked to Parkinson's disease: a relevant interaction?Biological chemistry, , 08-27, Volume: 400, Issue:9, 2019
Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats.Acta neuropathologica, , Volume: 138, Issue:4, 2019
Studying Parkinson's disease using Caenorhabditis elegans models in microfluidic devices.Integrative biology : quantitative biosciences from nano to macro, , 05-01, Volume: 11, Issue:5, 2019
SNCA rs11931074 polymorphism correlates with spontaneous brain activity and motor symptoms in Chinese patients with Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 126, Issue:8, 2019
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E46K mutant α-synuclein is more degradation resistant and exhibits greater toxic effects than wild-type α-synuclein in Drosophila models of Parkinson's disease.PloS one, , Volume: 14, Issue:6, 2019
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Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes.Nature neuroscience, , Volume: 22, Issue:7, 2019
A traffic jam leads to Lewy bodies.Nature neuroscience, , Volume: 22, Issue:7, 2019
Axonal pathology in hPSC-based models of Parkinson's disease results from loss of Nrf2 transcriptional activity at the Map1b gene locus.Proceedings of the National Academy of Sciences of the United States of America, , 07-09, Volume: 116, Issue:28, 2019
SNCA Rep1 promoter variability influences cognition in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:8, 2019
SNCA and mTOR Pathway Single Nucleotide Polymorphisms Interact to Modulate the Age at Onset of Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:9, 2019
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Serotonergic pathology and Braak's staging hypothesis in Parkinson's disease.The Lancet. Neurology, , Volume: 18, Issue:8, 2019
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Associations Between APOE Variants, Tau and α-Synuclein.Advances in experimental medicine and biology, , Volume: 1184, 2019
Extracellular α-synuclein enters dopaminergic cells by modulating flotillin-1-assisted dopamine transporter endocytosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 33, Issue:9, 2019
Identification of N-linked glycans as specific mediators of neuronal uptake of acetylated α-Synuclein.PLoS biology, , Volume: 17, Issue:6, 2019
Randomized phase I clinical trial of anti-α-synuclein antibody BIIB054.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:8, 2019
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Gastrodin protects dopaminergic neurons via insulin-like pathway in a Parkinson's disease model.BMC neuroscience, , 06-17, Volume: 20, Issue:1, 2019
Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo.Journal of visualized experiments : JoVE, , 06-02, Issue:148, 2019
α-Synuclein 2.0 - Moving towards Cell Type Specific Pathophysiology.Neuroscience, , 08-01, Volume: 412, 2019
Interrogating Parkinson's disease associated redox targets: Potential application of CRISPR editing.Free radical biology & medicine, , 11-20, Volume: 144, 2019
Oxidative stress in vagal neurons promotes parkinsonian pathology and intercellular α-synuclein transfer.The Journal of clinical investigation, , 06-13, Volume: 129, Issue:9, 2019
The early diagnosis of Parkinson's disease through combined biomarkers.Acta neurologica Scandinavica, , Volume: 140, Issue:4, 2019
Impairment of Nrf2- and Nitrergic-Mediated Gastrointestinal Motility in an MPTP Mouse Model of Parkinson's Disease.Digestive diseases and sciences, , Volume: 64, Issue:12, 2019
Patient-specific pluripotent stem cell-based Parkinson's disease models showing endogenous alpha-synuclein aggregation.BMB reports, , Volume: 52, Issue:6, 2019
Lycopodium Attenuates Loss of Dopaminergic Neurons by Suppressing Oxidative Stress and Neuroinflammation in a Rat Model of Parkinson's Disease.Molecules (Basel, Switzerland), , Jun-10, Volume: 24, Issue:11, 2019
Skin Fibroblasts as the Object for Clinical Diagnosis of Parkinson's Disease in Persons of Different Ages.Bulletin of experimental biology and medicine, , Volume: 167, Issue:1, 2019
GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson's Disease.Scientific reports, , 06-10, Volume: 9, Issue:1, 2019
Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery.Cells, , 06-09, Volume: 8, Issue:6, 2019
Dynamic Properties of Human α-Synuclein Related to Propensity to Amyloid Fibril Formation.Journal of molecular biology, , 08-09, Volume: 431, Issue:17, 2019
Salidroside protects SH‑SY5Y from pathogenic α‑synuclein by promoting cell autophagy via mediation of mTOR/p70S6K signaling.Molecular medicine reports, , Volume: 20, Issue:1, 2019
A secret that underlies Parkinson's disease: The damaging cycle.Neurochemistry international, , Volume: 129, 2019
α-Synuclein pathology in Parkinson's disease and related α-synucleinopathies.Neuroscience letters, , 09-14, Volume: 709, 2019
A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body-like pathology.Science translational medicine, , 06-05, Volume: 11, Issue:495, 2019
Alpha-synuclein at the nexus of genes and environment: the impact of environmental enrichment and stress on brain health and disease.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model.Acta neuropathologica, , Volume: 138, Issue:4, 2019
Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson's disease.BMC neurology, , Jun-04, Volume: 19, Issue:1, 2019
Spreading of alpha-synuclein - relevant or epiphenomenon?Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Pharmacological targeting of α-synuclein and TPPP/p25 in Parkinson's disease: challenges and opportunities in a Nutshell.FEBS letters, , Volume: 593, Issue:13, 2019
The issue of waste disposal in Parkinson's disease pathogenesis.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:7, 2019
Defining α-synuclein species responsible for Parkinson's disease phenotypes in mice.The Journal of biological chemistry, , 07-05, Volume: 294, Issue:27, 2019
Nitroalkylation of α-Synuclein by Nitro-Oleic Acid: Implications for Parkinson's Disease.Advances in experimental medicine and biology, , Volume: 1127, 2019
Peripheral mitochondrial function correlates with clinical severity in idiopathic Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:8, 2019
Parafoveal thinning of inner retina is associated with visual dysfunction in Lewy body diseases.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:9, 2019
Establishing a framework for neuropathological correlates and glymphatic system functioning in Parkinson's disease.Neuroscience and biobehavioral reviews, , Volume: 103, 2019
Revisiting the History of the 1997 Alpha-Synuclein Discovery in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 9, Issue:2, 2019
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Evaluation of Carnosine Intervention in the Thy1-aSyn Mouse Model of Parkinson's Disease.Neuroscience, , 07-15, Volume: 411, 2019
Age-dependent nigral dopaminergic neurodegeneration and α-synuclein accumulation in RGS6-deficient mice.JCI insight, , 05-23, Volume: 5, 2019
In-vitro and in-silico investigation of protective mechanisms of crocin against E46K α-synuclein amyloid formation.Molecular biology reports, , Volume: 46, Issue:4, 2019
Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson's disease.Scientific reports, , 05-21, Volume: 9, Issue:1, 2019
Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils.Neurobiology of disease, , Volume: 129, 2019
Central Nervous System-Derived Exosomal Alpha-Synuclein in Serum May Be a Biomarker in Parkinson's Disease.Neuroscience, , 08-10, Volume: 413, 2019
Alpha-synuclein gene polymorphism affects risk of dementia in Han Chinese with Parkinson's disease.Neuroscience letters, , 07-27, Volume: 706, 2019
Effects of alpha-synuclein post-translational modifications on metal binding.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Membrane interactions of intrinsically disordered proteins: The example of alpha-synuclein.Biochimica et biophysica acta. Proteins and proteomics, , Volume: 1867, Issue:10, 2019
C-terminal α-synuclein truncations are linked to cysteine cathepsin activity in Parkinson's disease.The Journal of biological chemistry, , 06-21, Volume: 294, Issue:25, 2019
Preclinical signs of Parkinson's disease: A possible association of Parkinson's disease with skin and hair features.Medical hypotheses, , Volume: 127, 2019
LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?Biochemical Society transactions, , 06-28, Volume: 47, Issue:3, 2019
Assessment of risk factor variants of LRRK2, MAPT, SNCA and TCEANC2 genes in Hungarian sporadic Parkinson's disease patients.Neuroscience letters, , 07-27, Volume: 706, 2019
Identifying the Pathological Domain of Alpha- Synuclein as a Therapeutic for Parkinson's Disease.International journal of molecular sciences, , May-11, Volume: 20, Issue:9, 2019
Targeting alpha synuclein and amyloid beta by a multifunctional, brain-penetrant dopamine D2/D3 agonist D-520: Potential therapeutic application in Parkinson's disease with dementia.Scientific reports, , 12-23, Volume: 9, Issue:1, 2019
Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification.Neurobiology of disease, , Volume: 129, 2019
Investigation of somatic CNVs in brains of synucleinopathy cases using targeted SNCA analysis and single cell sequencing.Acta neuropathologica communications, , 12-23, Volume: 7, Issue:1, 2019
Dystonia and Parkinson's disease: What is the relationship?Neurobiology of disease, , Volume: 132, 2019
Layer-specific axonal degeneration of serotonergic fibers in the prefrontal cortex of aged A53T α-synuclein-expressing mice.Neurobiology of aging, , Volume: 80, 2019
The Toxicity of Misfolded Protein Oligomers Is Independent of Their Secondary Structure.ACS chemical biology, , 07-19, Volume: 14, Issue:7, 2019
Vitamin B12 inhibits α-synuclein fibrillogenesis and protects against amyloid-induced cytotoxicity.Food & function, , May-22, Volume: 10, Issue:5, 2019
Parkinson's disease recovery by GM1 oligosaccharide treatment in the B4galnt1Scientific reports, , 12-18, Volume: 9, Issue:1, 2019
How is alpha-synuclein cleared from the cell?Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Temporal evolution of microglia and α-synuclein accumulation following foetal grafting in Parkinson's disease.Brain : a journal of neurology, , 06-01, Volume: 142, Issue:6, 2019
CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson's disease.Journal of neuroinflammation, , Dec-12, Volume: 16, Issue:1, 2019
Antibodies against alpha-synuclein: tools and therapies.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Progress of immunotherapy of anti-α-synuclein in Parkinson's disease.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 115, 2019
Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy.eLife, , 12-09, Volume: 8, 2019
Common genetic variants associated with Parkinson's disease display widespread signature of epigenetic plasticity.Scientific reports, , 12-05, Volume: 9, Issue:1, 2019
Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies.ACS chemical biology, , 06-21, Volume: 14, Issue:6, 2019
LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson's disease patients.Nature communications, , 12-05, Volume: 10, Issue:1, 2019
Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a Communications biology, , Volume: 2, 2019
SNCA but not DNM3 and GAK modifies age at onset of LRRK2-related Parkinson's disease in Chinese population.Journal of neurology, , Volume: 266, Issue:7, 2019
Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts.Nature communications, , 12-04, Volume: 10, Issue:1, 2019
Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia.The Journal of experimental medicine, , 06-03, Volume: 216, Issue:6, 2019
Luminescent conjugated oligothiophenes distinguish between α-synuclein assemblies of Parkinson's disease and multiple system atrophy.Acta neuropathologica communications, , 12-03, Volume: 7, Issue:1, 2019
Alpha-Synuclein Is a Target of Fic-Mediated Adenylylation/AMPylation: Possible Implications for Parkinson's Disease.Journal of molecular biology, , 05-31, Volume: 431, Issue:12, 2019
Viral mimetic priming enhances α-synuclein-induced degeneration: Implications for Parkinson's disease.Brain, behavior, and immunity, , Volume: 80, 2019
[Electroacupuncture improved locomotor function by regulating expression of tyrosine hydroxylase and α-synuclein proteins and transcription activating factor 6 and transcription factor X box binding protein 1 mRNAs in substantia nigra of rats with ParkinsZhen ci yan jiu = Acupuncture research, , Nov-25, Volume: 44, Issue:11, 2019
In Vivo Protein Complementation Demonstrates Presynaptic α-Synuclein Oligomerization and Age-Dependent Accumulation of 8-16-mer Oligomer Species.Cell reports, , Nov-26, Volume: 29, Issue:9, 2019
Cerebral mitochondrial electron transport chain dysfunction in multiple system atrophy and Parkinson's disease.Scientific reports, , 04-25, Volume: 9, Issue:1, 2019
Hippocampal CA2 Lewy pathology is associated with cholinergic degeneration in Parkinson's disease with cognitive decline.Acta neuropathologica communications, , 04-25, Volume: 7, Issue:1, 2019
Necrosis, apoptosis, necroptosis, three modes of action of dopaminergic neuron neurotoxins.PloS one, , Volume: 14, Issue:4, 2019
Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease.Scientific reports, , 11-22, Volume: 9, Issue:1, 2019
Phosphorylated NUB1 distinguishes α-synuclein in Lewy bodies from that in glial cytoplasmic inclusions in multiple system atrophy.Brain pathology (Zurich, Switzerland), , Volume: 29, Issue:6, 2019
Local vulnerability and global connectivity jointly shape neurodegenerative disease propagation.PLoS biology, , Volume: 17, Issue:11, 2019
The landscape of multiscale transcriptomic networks and key regulators in Parkinson's disease.Nature communications, , 11-20, Volume: 10, Issue:1, 2019
Gene co-expression analysis of the human substantia nigra identifies BMP2 as a neurotrophic factor that can promote neurite growth in cells overexpressing wild-type or A53T α-synuclein.Parkinsonism & related disorders, , Volume: 64, 2019
α-Synuclein in blood cells differentiates Parkinson's disease from healthy controls.Annals of clinical and translational neurology, , Volume: 6, Issue:12, 2019
Quantitative Characterization of α-Synuclein Aggregation in Living Cells through Automated Microfluidics Feedback Control.Cell reports, , 04-16, Volume: 27, Issue:3, 2019
In Vivo Phenotyping of Familial Parkinson's Disease with Human Induced Pluripotent Stem Cells: A Proof-of-Concept Study.Neurochemical research, , Volume: 44, Issue:6, 2019
Autophagic- and Lysosomal-Related Biomarkers for Parkinson's Disease: Lights and Shadows.Cells, , 10-25, Volume: 8, Issue:11, 2019
AAV2/DJ-mediated alpha-synuclein overexpression in the rat substantia nigra as early stage model of Parkinson's disease.Cell and tissue research, , Volume: 378, Issue:1, 2019
The Overcrowded Crossroads: Mitochondria, Alpha-Synuclein, and the Endo-Lysosomal System Interaction in Parkinson's Disease.International journal of molecular sciences, , Oct-25, Volume: 20, Issue:21, 2019
Mitochondrial damage by α-synuclein causes cell death in human dopaminergic neurons.Cell death & disease, , 11-14, Volume: 10, Issue:11, 2019
Neurodegeneration and contralateral α-synuclein induction after intracerebral α-synuclein injections in the anterior olfactory nucleus of a Parkinson's disease A53T mouse model.Acta neuropathologica communications, , 04-15, Volume: 7, Issue:1, 2019
Targeting α-Synuclein in Parkinson's Disease: Progress Towards the Development of Disease-Modifying Therapeutics.Drugs, , Volume: 79, Issue:8, 2019
α-Synuclein toxicity in yeast and human cells is caused by cell cycle re-entry and autophagy degradation of ribonucleotide reductase 1.Aging cell, , Volume: 18, Issue:4, 2019
Binding of α-synuclein oligomers to Cx32 facilitates protein uptake and transfer in neurons and oligodendrocytes.Acta neuropathologica, , Volume: 138, Issue:1, 2019
Neurotoxic and Neuroprotective Role of Exosomes in Parkinson's Disease.Current pharmaceutical design, , Volume: 25, Issue:42, 2019
Parkinson's disease: How do highly toxic α-Synuclein/PAR aggregates mediate neuronal cell death?Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:5, 2019
[The Propagation Hypothesis of Prion-like Protein Agregates in Neurodegenerative Diseases].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 71, Issue:11, 2019
α-Synuclein Penetrates Mucin Hydrogels Despite Its Mucoadhesive Properties.Biomacromolecules, , 12-09, Volume: 20, Issue:12, 2019
Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:6, 2019
Effect of naturally occurring α-synuclein-antibodies on toxic α-synuclein-fragments.Neuroscience letters, , 06-21, Volume: 704, 2019
A split-GFP tool reveals differences in the sub-mitochondrial distribution of wt and mutant alpha-synuclein.Cell death & disease, , 11-12, Volume: 10, Issue:11, 2019
Caffeic acid reduces A53T α-synuclein by activating JNK/Bcl-2-mediated autophagy in vitro and improves behaviour and protects dopaminergic neurons in a mouse model of Parkinson's disease.Pharmacological research, , Volume: 150, 2019
Nitrated alpha-synuclein in minor salivary gland biopsies in Parkinson's disease.Neuroscience letters, , 06-21, Volume: 704, 2019
Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease.Molecular neurodegeneration, , 11-08, Volume: 14, Issue:1, 2019
Mass Spectrometric Analysis of Lewy Body-Enriched α-Synuclein in Parkinson's Disease.Journal of proteome research, , 05-03, Volume: 18, Issue:5, 2019
Partially oxidized DJ-1 inhibits α-synuclein nucleation and remodels mature α-synuclein fibrils in vitro.Communications biology, , Volume: 2, 2019
The effects of acupuncture and electroacupuncture on Parkinson's disease: Current status and future perspectives for molecular mechanisms.Journal of cellular biochemistry, , Volume: 120, Issue:8, 2019
Loss of One Engrailed1 Allele Enhances Induced α-Synucleinopathy.Journal of Parkinson's disease, , Volume: 9, Issue:2, 2019
Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs.Nature structural & molecular biology, , Volume: 26, Issue:11, 2019
Hsp110 mitigates α-synuclein pathology in vivo.Proceedings of the National Academy of Sciences of the United States of America, , 11-26, Volume: 116, Issue:48, 2019
[Differential diagnosis of RBD symptomatology (idiopathic RBD or RBD mimics)].Rinsho shinkeigaku = Clinical neurology, , Apr-25, Volume: 59, Issue:4, 2019
ARSA variants in α-synucleinopathies.Brain : a journal of neurology, , 12-01, Volume: 142, Issue:12, 2019
LRRK2 modifies α-syn pathology and spread in mouse models and human neurons.Acta neuropathologica, , Volume: 137, Issue:6, 2019
Circulating amino acid signature in older people with Parkinson's disease: A metabolic complement to the EXosomes in PArkiNson Disease (EXPAND) study.Experimental gerontology, , Volume: 128, 2019
Recapitulating Parkinson's disease pathology in a three-dimensional human neural cell culture model.Disease models & mechanisms, , 04-09, Volume: 12, Issue:4, 2019
Intrastriatal injection of alpha-synuclein fibrils induces Parkinson-like pathology in macaques.Brain : a journal of neurology, , 11-01, Volume: 142, Issue:11, 2019
Fatty Acid-Binding Protein 3 is Critical for α-Synuclein Uptake and MPPInternational journal of molecular sciences, , Oct-28, Volume: 20, Issue:21, 2019
SERF engages in a fuzzy complex that accelerates primary nucleation of amyloid proteins.Proceedings of the National Academy of Sciences of the United States of America, , 11-12, Volume: 116, Issue:46, 2019
Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies.Cells, , 10-10, Volume: 8, Issue:10, 2019
Increased α-synuclein levels in patients with sleep apnoea might be involved in PD pathogenesis.Nature reviews. Neurology, , Volume: 15, Issue:5, 2019
Redox active metals in neurodegenerative diseases.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, , Volume: 24, Issue:8, 2019
Binding of Noradrenaline to Native and Intermediate States during the Fibrillation of α-Synuclein Leads to the Formation of Stable and Structured Cytotoxic Species.ACS chemical neuroscience, , 06-19, Volume: 10, Issue:6, 2019
Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein.Neuron, , 12-04, Volume: 104, Issue:5, 2019
[Research progress on neural mechanism of peripheral inflammation in Parkinson's disease].Sheng li xue bao : [Acta physiologica Sinica], , Oct-25, Volume: 71, Issue:5, 2019
Apelin-13 protects dopaminergic neurons in MPTP-induced Parkinson's disease model mice through inhibiting endoplasmic reticulum stress and promoting autophagy.Brain research, , 07-15, Volume: 1715, 2019
Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior.Cell reports, , 10-22, Volume: 29, Issue:4, 2019
Plasma alpha-synuclein detected by single molecule array is increased in PD.Annals of clinical and translational neurology, , Volume: 6, Issue:3, 2019
IRE1 promotes neurodegeneration through autophagy-dependent neuron death in the Drosophila model of Parkinson's disease.Cell death & disease, , 10-22, Volume: 10, Issue:11, 2019
Sex Differences in Rotenone Sensitivity Reflect the Male-to-Female Ratio in Human Parkinson's Disease Incidence.Toxicological sciences : an official journal of the Society of Toxicology, , 07-01, Volume: 170, Issue:1, 2019
Chronic nigral neuromodulation aggravates behavioral deficits and synaptic changes in an α-synuclein based rat model for Parkinson's disease.Acta neuropathologica communications, , 10-22, Volume: 7, Issue:1, 2019
Alpha-synuclein stepwise aggregation reveals features of an early onset mutation in Parkinson's disease.Communications biology, , Volume: 2, 2019
Pharmacokinetics and pharmacodynamics of a single dose Nilotinib in individuals with Parkinson's disease.Pharmacology research & perspectives, , Volume: 7, Issue:2, 2019
Electrochemical biosensors for the detection and study of α-synuclein related to Parkinson's disease - A review.Analytica chimica acta, , Dec-16, Volume: 1089, 2019
Feasibility of repeat and bilateral submandibular gland needle biopsies in Parkinson's disease.Parkinsonism & related disorders, , Volume: 68, 2019
Clinical variability in Chinese families with Parkinson disease and SNCA duplication, including the shortest 139kb duplication.Parkinsonism & related disorders, , Volume: 68, 2019
The aggregation state of α-synuclein deposits in dermal nerve fibers of patients with Parkinson's disease resembles that in the brain.Parkinsonism & related disorders, , Volume: 64, 2019
Neuronal exosomes in saliva of Parkinson's disease patients: A pilot study.Parkinsonism & related disorders, , Volume: 67, 2019
Two conformationally distinct α-synuclein oligomers share common epitopes and the ability to impair long-term potentiation.PloS one, , Volume: 14, Issue:3, 2019
Distinct Autoimmune Anti-α-Synuclein Antibody Patterns in Multiple System Atrophy and Parkinson's Disease.Frontiers in immunology, , Volume: 10, 2019
The Appendix in Parkinson's Disease: From Vestigial Remnant to Vital Organ?Journal of Parkinson's disease, , Volume: 9, Issue:s2, 2019
Dihydromyricetin Inhibits α-Synuclein Aggregation, Disrupts Preformed Fibrils, and Protects Neuronal Cells in Culture against Amyloid-Induced Cytotoxicity.Journal of agricultural and food chemistry, , Apr-10, Volume: 67, Issue:14, 2019
Stabilization of α-synuclein oligomers using formaldehyde.PloS one, , Volume: 14, Issue:10, 2019
Clinical and neuropathological differences between Parkinson's disease, Parkinson's disease dementia and dementia with Lewy bodies - current issues and future directions.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Lower nucleus accumbens α-synuclein load and D3 receptor levels in Parkinson's disease with impulsive compulsive behaviours.Brain : a journal of neurology, , 11-01, Volume: 142, Issue:11, 2019
From Yeast to Humans: Leveraging New Approaches in Yeast to Accelerate Discovery of Therapeutic Targets for Synucleinopathies.Methods in molecular biology (Clifton, N.J.), , Volume: 2049, 2019
Label-free detection of early oligomerization of α-synuclein and its mutants A30P/E46K through solid-state nanopores.Nanoscale, , Mar-28, Volume: 11, Issue:13, 2019
Calpain in the cleavage of alpha-synuclein and the pathogenesis of Parkinson's disease.Progress in molecular biology and translational science, , Volume: 167, 2019
Unbalanced calcium channel activity underlies selective vulnerability of nigrostriatal dopaminergic terminals in Parkinsonian mice.Scientific reports, , 03-19, Volume: 9, Issue:1, 2019
Mutations in CHCHD2 cause α-synuclein aggregation.Human molecular genetics, , 12-01, Volume: 28, Issue:23, 2019
Interaction between Copper Chaperone Atox1 and Parkinson's Disease Protein α-Synuclein Includes Metal-Binding Sites and Occurs in Living Cells.ACS chemical neuroscience, , 11-20, Volume: 10, Issue:11, 2019
Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity.Acta neuropathologica, , Volume: 137, Issue:6, 2019
Gastrointestinal Immunity and Alpha-Synuclein.Journal of Parkinson's disease, , Volume: 9, Issue:s2, 2019
The interplay between parkin and alpha-synuclein; possible implications for the pathogenesis of Parkinson's disease.Acta neurobiologiae experimentalis, , Volume: 79, Issue:3, 2019
Microbiome, Parkinson's Disease and Molecular Mimicry.Cells, , 03-07, Volume: 8, Issue:3, 2019
Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology.Neurobiology of aging, , Volume: 83, 2019
Microglia in Parkinson's Disease.Advances in experimental medicine and biology, , Volume: 1175, 2019
Autoimmunity in Parkinson's Disease: The Role of α-Synuclein-Specific T Cells.Frontiers in immunology, , Volume: 10, 2019
α-Synuclein misfolding and aggregation: Implications in Parkinson's disease pathogenesis.Biochimica et biophysica acta. Proteins and proteomics, , Volume: 1867, Issue:10, 2019
Levels of oligomeric α-Synuclein in reflex tears distinguish Parkinson's disease patients from healthy controls.Biomarkers in medicine, , Volume: 13, Issue:17, 2019
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Extreme sleep pattern in Lewy body dementia: a hypothalamic matter?BMJ case reports, , Mar-09, Volume: 12, Issue:3, 2019
miR-let-7a suppresses α-Synuclein-induced microglia inflammation through targeting STAT3 in Parkinson's disease.Biochemical and biophysical research communications, , 11-19, Volume: 519, Issue:4, 2019
Predictive model of spread of Parkinson's pathology using network diffusion.NeuroImage, , 05-15, Volume: 192, 2019
Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis.Nature communications, , 03-07, Volume: 10, Issue:1, 2019
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Clinical Reasoning: A 58-year-old man with hand tremor and episodes of neck pain.Neurology, , 09-17, Volume: 93, Issue:12, 2019
An attempt to elucidate the role of iron and zinc ions in development of Alzheimer's and Parkinson's diseases.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 111, 2019
Silver staining (Campbell-Switzer) of neuronal α-synuclein assemblies induced by multiple system atrophy and Parkinson's disease brain extracts in transgenic mice.Acta neuropathologica communications, , 09-16, Volume: 7, Issue:1, 2019
Proteomics-Based Monitoring of Pathway Activity Reveals that Blocking Diacylglycerol Biosynthesis Rescues from Alpha-Synuclein Toxicity.Cell systems, , 09-25, Volume: 9, Issue:3, 2019
Comparative study of cerebrospinal fluid α-synuclein seeding aggregation assays for diagnosis of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:4, 2019
Anti-ageing and anti-Parkinsonian effects of natural flavonol, tambulin from Zanthoxyllum aramatum promotes longevity in Caenorhabditis elegans.Experimental gerontology, , Volume: 120, 2019
Cyclized NDGA modifies dynamic α-synuclein monomers preventing aggregation and toxicity.Scientific reports, , 02-27, Volume: 9, Issue:1, 2019
Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology.Molecular therapy : the journal of the American Society of Gene Therapy, , 12-04, Volume: 27, Issue:12, 2019
Endosomal trafficking leads the way in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:4, 2019
Another Brick in the Wall.Journal of innate immunity, , Volume: 11, Issue:2, 2019
Brain-First versus Gut-First Parkinson's Disease: A Hypothesis.Journal of Parkinson's disease, , Volume: 9, Issue:s2, 2019
LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice.Acta neuropathologica communications, , 02-26, Volume: 7, Issue:1, 2019
Dopamine Cytotoxicity on SH-SY5Y Cells: Involvement of α-Synuclein and Relevance in the Neurodegeneration of Sporadic Parkinson's Disease.Neurotoxicity research, , Volume: 35, Issue:4, 2019
Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson's disease.Nature communications, , 09-02, Volume: 10, Issue:1, 2019
Naturally occurring antibodies isolated from PD patients inhibit synuclein seeding in vitro and recognize Lewy pathology.Acta neuropathologica, , Volume: 137, Issue:5, 2019
Diagnostic utility of gut α-synuclein in Parkinson's disease: A systematic review and meta-analysis.Behavioural brain research, , 05-17, Volume: 364, 2019
Lots of Movement in Gut and Parkinson's Research.Trends in endocrinology and metabolism: TEM, , Volume: 30, Issue:10, 2019
Iron Pathophysiology in Parkinson Diseases.Advances in experimental medicine and biology, , Volume: 1173, 2019
The deglycase activity of DJ-1 mitigates α-synuclein glycation and aggregation in dopaminergic cells: Role of oxidative stress mediated downregulation of DJ-1 in Parkinson's disease.Free radical biology & medicine, , 05-01, Volume: 135, 2019
Alterations in Blood Monocyte Functions in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:11, 2019
Seeding of protein aggregation causes cognitive impairment in rat model of cortical synucleinopathy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:11, 2019
Switching on Endogenous Metal Binding Proteins in Parkinson's Disease.Cells, , 02-19, Volume: 8, Issue:2, 2019
SMPD1 mutations, activity, and α-synuclein accumulation in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:4, 2019
Microglia as modulators of exosomal alpha-synuclein transmission.Cell death & disease, , 02-20, Volume: 10, Issue:3, 2019
Hyperosmotic stress induces cell-dependent aggregation of α-synuclein.Scientific reports, , 02-19, Volume: 9, Issue:1, 2019
High lithium levels in tobacco may account for reduced incidences of both Parkinson's disease and melanoma in smokers through enhanced β-catenin-mediated activity.Medical hypotheses, , Volume: 131, 2019
Synuclein Meeting 2019: where we are and where we need to go.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
A PARP-1 Feed-Forward Mechanism To Accelerate α-Synuclein Toxicity in Parkinson's Disease.Biochemistry, , 02-19, Volume: 58, Issue:7, 2019
Exploring the Peripheral Initiation of Parkinson's Disease in Animal Models.Neuron, , 08-21, Volume: 103, Issue:4, 2019
The primary neuronal cells are more resistant than PC12 cells to α-synuclein toxic aggregates.Neuroscience letters, , 05-14, Volume: 701, 2019
Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies.JCI insight, , 08-22, Volume: 4, Issue:16, 2019
Polysomnographic data in Dementia with Lewy Bodies: correlation with clinical symptoms and comparison with other α-synucleinopathies.Sleep medicine, , Volume: 55, 2019
Deployment of Label-Free Quantitative Olfactory Proteomics to Detect Cerebrospinal Fluid Biomarker Candidates in Synucleinopathies.Methods in molecular biology (Clifton, N.J.), , Volume: 2044, 2019
Roles for the adaptive immune system in Parkinson's and Alzheimer's diseases.Current opinion in immunology, , Volume: 59, 2019
Expression and Purification of Untagged α-Synuclein.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
Parkinson's disease is a type of amyloidosis featuring accumulation of amyloid fibrils of α-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , 09-03, Volume: 116, Issue:36, 2019
In Situ Peroxidase Labeling and Mass Spectrometry of Alpha-Synuclein in Rat Cortical Neurons.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
N-Terminal Acetylation Affects α-Synuclein Fibril Polymorphism.Biochemistry, , 09-03, Volume: 58, Issue:35, 2019
Detection of α-Synuclein in Biological Samples Using Mass Spectrometry.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
Monitoring α-Synuclein Proteotoxicity in Drosophila Models.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
Measuring Mitochondrial Dysfunction Caused by Soluble α-Synuclein Oligomers.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
Neuroprotective and Neurotherapeutic Effects of Tetrahedral Framework Nucleic Acids on Parkinson's Disease ACS applied materials & interfaces, , Sep-11, Volume: 11, Issue:36, 2019
Yeast-Based Screens to Target Alpha-Synuclein Toxicity.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
Low prevalence of known pathogenic mutations in dominant PD genes: A Swedish multicenter study.Parkinsonism & related disorders, , Volume: 66, 2019
Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson's disease.Molecular neurodegeneration, , 08-16, Volume: 14, Issue:1, 2019
Studying α-Synuclein Conformation by Intact-Cell Cross-Linking.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
Alpha-Synuclein Proximity Ligation Assay (AS-PLA) in Brain Sections to Probe for Alpha-Synuclein Oligomers.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
Complex of EGCG with Cu(II) Suppresses Amyloid Aggregation and Cu(II)-Induced Cytotoxicity of α-Synuclein.Molecules (Basel, Switzerland), , Aug-14, Volume: 24, Issue:16, 2019
Calling α-synuclein a prion is scientifically justifiable.Acta neuropathologica, , Volume: 138, Issue:4, 2019
Quantification of Alpha-Synuclein in Biological Fluids by Electrochemiluminescence-Based Detection.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
Spinal cord α-synuclein deposition associated with myoclonus in patients with MSA-C.Neurology, , 08-13, Volume: 93, Issue:7, 2019
Abnormal α-synuclein deposits in skin nerves: intra- and inter-laboratory reproducibility.European journal of neurology, , Volume: 26, Issue:10, 2019
Extracellular microvesicles-derived from microglia treated with unaggregated α-synuclein attenuate mitochondrial fission and toxicity-induced by Parkinsonian toxin MPPBiochemical and biophysical research communications, , 10-01, Volume: 517, Issue:4, 2019
rAAV-based brain slice culture models of Alzheimer's and Parkinson's disease inclusion pathologies.The Journal of experimental medicine, , 03-04, Volume: 216, Issue:3, 2019
Salivary alpha-synuclein as a biomarker for Parkinson's disease: a systematic review.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 126, Issue:11, 2019
Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity.Redox biology, , Volume: 22, 2019
Peripheral Inflammation Regulates CNS Immune Surveillance Through the Recruitment of Inflammatory Monocytes Upon Systemic α-Synuclein Administration.Frontiers in immunology, , Volume: 10, 2019
Age- and α-Synuclein-Dependent Degeneration of Dopamine and Noradrenaline Neurons in the Annual Killifish Nothobranchius furzeri.Cell reports, , 02-12, Volume: 26, Issue:7, 2019
Non-Cell-Autonomous Neurotoxicity in Parkinson's Disease Mediated by Astroglial α-Synuclein.Stem cell reports, , 02-12, Volume: 12, Issue:2, 2019
Nucleic Acid-Based Therapeutics for Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 16, Issue:2, 2019
A30P mutant α-synuclein impairs autophagic flux by inactivating JNK signaling to enhance ZKSCAN3 activity in midbrain dopaminergic neurons.Cell death & disease, , 02-12, Volume: 10, Issue:2, 2019
Methionine oxidation in α-synuclein inhibits its propensity for ordered secondary structure.The Journal of biological chemistry, , 04-05, Volume: 294, Issue:14, 2019
Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons.Human molecular genetics, , 06-15, Volume: 28, Issue:12, 2019
Association between physical activity and dementia's risk factors in patients with Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 126, Issue:3, 2019
Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases.Neurology, , 02-12, Volume: 92, Issue:7, 2019
Clinical Trial Highlights: Targetting Alpha-Synuclein.Journal of Parkinson's disease, , Volume: 9, Issue:1, 2019
The Role of NOX4 in Parkinson's Disease with Dementia.International journal of molecular sciences, , Feb-06, Volume: 20, Issue:3, 2019
Multiple molecular pathways stimulating macroautophagy protect from alpha-synuclein-induced toxicity in human neurons.Neuropharmacology, , 05-01, Volume: 149, 2019
The prion-like propagation hypothesis in Alzheimer's and Parkinson's disease.Current opinion in neurology, , Volume: 32, Issue:2, 2019
Retinal α-synuclein deposits in Parkinson's disease patients and animal models.Acta neuropathologica, , Volume: 137, Issue:3, 2019
Moving forward the in vivo diagnosis of the synucleinopathies.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 29, Issue:6, 2019
l-3,4-dihydroxyphenylalanine (l-DOPA) modulates brain iron, dopaminergic neurodegeneration and motor dysfunction in iron overload and mutant alpha-synuclein mouse models of Parkinson's disease.Journal of neurochemistry, , Volume: 150, Issue:1, 2019
Plasma alpha-synuclein levels in patients with Parkinson's disease: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 40, Issue:5, 2019
Alpha-Synuclein in Peripheral Tissues in Parkinson's Disease.ACS chemical neuroscience, , 02-20, Volume: 10, Issue:2, 2019
Upregulation of the p53-p21 pathway by G2019S LRRK2 contributes to the cellular senescence and accumulation of α-synuclein.Cell cycle (Georgetown, Tex.), , Volume: 18, Issue:4, 2019
Novel Immunotherapeutic Approaches to Target Alpha-Synuclein and Related Neuroinflammation in Parkinson's Disease.Cells, , 01-31, Volume: 8, Issue:2, 2019
PARP Inhibitors and Parkinson's Disease.The New England journal of medicine, , 01-31, Volume: 380, Issue:5, 2019
Selective inhibition of mitochondrial sodium-calcium exchanger protects striatal neurons from α-synuclein plus rotenone induced toxicity.Cell death & disease, , 01-28, Volume: 10, Issue:2, 2019
The prion-like spreading of α-synuclein: From in vitro to in vivo models of Parkinson's disease.Ageing research reviews, , Volume: 50, 2019
GBA haploinsufficiency accelerates alpha-synuclein pathology with altered lipid metabolism in a prodromal model of Parkinson's disease.Human molecular genetics, , 06-01, Volume: 28, Issue:11, 2019
Detection of Parkinson's Disease through the Peptoid Recognizing α-Synuclein in Serum.ACS chemical neuroscience, , 03-20, Volume: 10, Issue:3, 2019
Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose.Scientific reports, , 01-24, Volume: 9, Issue:1, 2019
Regulatory Mechanism of miR-543-3p on GLT-1 in a Mouse Model of Parkinson's Disease.ACS chemical neuroscience, , 03-20, Volume: 10, Issue:3, 2019
Exosomes in Parkinson's Disease: Current Perspectives and Future Challenges.ACS chemical neuroscience, , 02-20, Volume: 10, Issue:2, 2019
High Selectivity and Sensitivity of Oligomeric p-Phenylene Ethynylenes for Detecting Fibrillar and Prefibrillar Amyloid Protein Aggregates.ACS chemical neuroscience, , 03-20, Volume: 10, Issue:3, 2019
Gut-brain axis and the spread of α-synuclein pathology: Vagal highway or dead end?Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:3, 2019
α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 01-29, Volume: 116, Issue:5, 2019
The toxin MPTP generates similar cognitive and locomotor deficits in hTau and tau knock-out mice.Brain research, , 05-15, Volume: 1711, 2019
Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network.Stem cell reports, , 02-12, Volume: 12, Issue:2, 2019
Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease.Stem cell reports, , 02-12, Volume: 12, Issue:2, 2019
α-Synuclein and Glia in Parkinson's Disease: A Beneficial or a Detrimental Duet for the Endo-Lysosomal System?Cellular and molecular neurobiology, , Volume: 39, Issue:2, 2019
CSF Biomarkers for Early Diagnosis of Synucleinopathies: Focus on Idiopathic RBD.Current neurology and neuroscience reports, , 01-14, Volume: 19, Issue:2, 2019
Exploring the Roles of Post-Translational Modifications in the Pathogenesis of Parkinson's Disease Using Synthetic and Semisynthetic Modified α-Synuclein.ACS chemical neuroscience, , 02-20, Volume: 10, Issue:2, 2019
The effect of mutant GBA1 on accumulation and aggregation of α-synuclein.Human molecular genetics, , 06-01, Volume: 28, Issue:11, 2019
Living in Promiscuity: The Multiple Partners of Alpha-Synuclein at the Synapse in Physiology and Pathology.International journal of molecular sciences, , Jan-02, Volume: 20, Issue:1, 2019
The Cell-Death-Associated Polymer PAR Feeds Forward α-Synuclein Toxicity in Parkinson's Disease.Molecular cell, , 01-03, Volume: 73, Issue:1, 2019
Different Effects of α-Synuclein Mutants on Lipid Binding and Aggregation Detected by Single Molecule Fluorescence Spectroscopy and ThT Fluorescence-Based Measurements.ACS chemical neuroscience, , 03-20, Volume: 10, Issue:3, 2019
Treadmill exercise intervention improves gait and postural control in alpha-synuclein mouse models without inducing cerebral autophagy.Behavioural brain research, , 05-02, Volume: 363, 2019
Systematically analyzing rare variants of autosomal-dominant genes for sporadic Parkinson's disease in a Chinese cohort.Neurobiology of aging, , Volume: 76, 2019
Immunoreactivity of a G protein-coupled l-DOPA receptor GPR143, in Lewy bodies.Neuroscience research, , Volume: 148, 2019
Degeneration of dopaminergic circuitry influences depressive symptoms in Lewy body disorders.Brain pathology (Zurich, Switzerland), , Volume: 29, Issue:4, 2019
Aldehyde adducts inhibit 3,4-dihydroxyphenylacetaldehyde-induced α-synuclein aggregation and toxicity: Implication for Parkinson neuroprotective therapy.European journal of pharmacology, , Feb-15, Volume: 845, 2019
Gold nanoclusters for Parkinson's disease treatment.Biomaterials, , Volume: 194, 2019
Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer's and Parkinson disease pathology.Biochimica et biophysica acta. Molecular basis of disease, , 08-01, Volume: 1865, Issue:8, 2019
Hinokitiol Offers Neuroprotection Against 6-OHDA-Induced Toxicity in SH-SY5Y Neuroblastoma Cells by Downregulating mRNA Expression of MAO/α-Synuclein/LRRK2/PARK7/PINK1/PTEN Genes.Neurotoxicity research, , Volume: 35, Issue:4, 2019
Iron-related nigral degeneration influences functional topology mediated by striatal dysfunction in Parkinson's disease.Neurobiology of aging, , Volume: 75, 2019
Anti-Parkinson activity of bioactive substances extracted from Holothuria leucospilota.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 109, 2019
TLR4 absence reduces neuroinflammation and inflammasome activation in Parkinson's diseases in vivo model.Brain, behavior, and immunity, , Volume: 76, 2019
Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders.Annals of neurology, , Volume: 85, Issue:2, 2019
Downregulation of tyrosine hydroxylase phenotype after AAV injection above substantia nigra: Caution in experimental models of Parkinson's disease.Journal of neuroscience research, , Volume: 97, Issue:3, 2019
Disease model organism for Parkinson disease: Drosophila melanogaster.BMB reports, , Volume: 52, Issue:4, 2019
Cerebrospinal fluid biomarker for Parkinson's disease: An overview.Molecular and cellular neurosciences, , Volume: 97, 2019
Parkinson's disease: a short story of 200 years.Histology and histopathology, , Volume: 34, Issue:6, 2019
Heterogeneity in gut microbiota drive polyphenol metabolism that influences α-synuclein misfolding and toxicity.The Journal of nutritional biochemistry, , Volume: 64, 2019
Biochemical and morphological classification of disease-associated alpha-synuclein mutants aggregates.Biochemical and biophysical research communications, , 01-15, Volume: 508, Issue:3, 2019
Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.Molecular cell, , 03-07, Volume: 73, Issue:5, 2019
Synaptic, Mitochondrial, and Lysosomal Dysfunction in Parkinson's Disease.Trends in neurosciences, , Volume: 42, Issue:2, 2019
CSF β-amyloidNeurology, , 01-01, Volume: 92, Issue:1, 2019
Genetic variants of PARK genes in Korean patients with early-onset Parkinson's disease.Neurobiology of aging, , Volume: 75, 2019
Development of FABP3 ligands that inhibit arachidonic acid-induced α-synuclein oligomerization.Brain research, , 03-15, Volume: 1707, 2019
Pathogenesis-targeted therapeutic strategies in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:1, 2019
The role of posttranslational modifications of α-synuclein and LRRK2 in Parkinson's disease: Potential contributions of environmental factors.Biochimica et biophysica acta. Molecular basis of disease, , 08-01, Volume: 1865, Issue:8, 2019
Naturally occurring autoantibodies against α-synuclein rescues memory and motor deficits and attenuates α-synuclein pathology in mouse model of Parkinson's disease.Neurobiology of disease, , Volume: 124, 2019
Parkinson's disease and multiple system atrophy have distinct α-synuclein seed characteristics.The Journal of biological chemistry, , 01-18, Volume: 294, Issue:3, 2019
Engineering synucleinopathy-resistant human dopaminergic neurons by CRISPR-mediated deletion of the SNCA gene.The European journal of neuroscience, , Volume: 49, Issue:4, 2019
Alpha-synuclein in salivary gland as biomarker for Parkinson's disease.Reviews in the neurosciences, , 07-26, Volume: 30, Issue:5, 2019
Diagnostic biomarkers for Parkinson's disease: focus on α-synuclein in cerebrospinal fluid.Parkinsonism & related disorders, , Volume: 59, 2019
Cerebrospinal fluid levels of alpha-synuclein measured using a poly-glutamic acid-modified gold nanoparticle-doped disposable neuro-biosensor system.The Analyst, , Jan-14, Volume: 144, Issue:2, 2019
Association of SNCA variants with α-synuclein of gastric and colonic mucosa in Parkinson's disease.Parkinsonism & related disorders, , Volume: 61, 2019
Neuroprotective effects of Astilbin on MPTP-induced Parkinson's disease mice: Glial reaction, α-synuclein expression and oxidative stress.International immunopharmacology, , Volume: 66, 2019
Histamine-4 receptor antagonist JNJ7777120 inhibits pro-inflammatory microglia and prevents the progression of Parkinson-like pathology and behaviour in a rat model.Brain, behavior, and immunity, , Volume: 76, 2019
A Proposed Roadmap for Parkinson's Disease Proof of Concept Clinical Trials Investigating Compounds Targeting Alpha-Synuclein.Journal of Parkinson's disease, , Volume: 9, Issue:1, 2019
Interpreting Genetic Variants: Hints from a Family Cluster of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 9, Issue:1, 2019
New Era in disease modification in Parkinson's disease: Review of genetically targeted therapeutics.Parkinsonism & related disorders, , Volume: 59, 2019
Expression of α-synuclein is regulated in a neuronal cell type-dependent manner.Anatomical science international, , Volume: 94, Issue:1, 2019
Mathematical Biology Models of Parkinson's Disease.CPT: pharmacometrics & systems pharmacology, , Volume: 8, Issue:2, 2019
Role of Parkinson's Disease-Linked Mutations and N-Terminal Acetylation on the Oligomerization of α-Synuclein Induced by 3,4-Dihydroxyphenylacetaldehyde.ACS chemical neuroscience, , 01-16, Volume: 10, Issue:1, 2019
CSF α-synuclein inversely correlates with non-motor symptoms in a cohort of PD patients.Parkinsonism & related disorders, , Volume: 61, 2019
Baseline concentration of misfolded α-synuclein aggregates in cerebrospinal fluid predicts risk of cognitive decline in Parkinson's disease.Neuropathology and applied neurobiology, , Volume: 45, Issue:4, 2019
Triggers, Facilitators, and Aggravators: Redefining Parkinson's Disease Pathogenesis.Trends in neurosciences, , Volume: 42, Issue:1, 2019
Submandibular gland is a suitable site for alpha synuclein pathology in Parkinson disease.Parkinsonism & related disorders, , Volume: 58, 2019
Modeling Parkinson's disease in adult Drosophila.Journal of neuroscience methods, , 01-01, Volume: 311, 2019
Ubiquitin specific protease-13 independently regulates parkin ubiquitination and alpha-synuclein clearance in alpha-synucleinopathies.Human molecular genetics, , 02-15, Volume: 28, Issue:4, 2019
Disruptive membrane interactions of alpha-synuclein aggregates.Biochimica et biophysica acta. Proteins and proteomics, , Volume: 1867, Issue:5, 2019
Multiplication of the SNCA locus exacerbates neuronal nuclear aging.Human molecular genetics, , 02-01, Volume: 28, Issue:3, 2019
Phosphorylated α-synuclein deposits in sural nerve deriving from Schwann cells: A biomarker for Parkinson's disease.Parkinsonism & related disorders, , Volume: 60, 2019
Interplay between α-synuclein amyloid formation and membrane structure.Biochimica et biophysica acta. Proteins and proteomics, , Volume: 1867, Issue:5, 2019
Modulating α-synuclein fibril formation using DNA tetrahedron nanostructures.Biochimica et biophysica acta. General subjects, , Volume: 1863, Issue:1, 2019
Mechanistic Insight into the Binding Profile of DCVJ and α-Synuclein Fibril Revealed by Multiscale Simulations.ACS chemical neuroscience, , 01-16, Volume: 10, Issue:1, 2019
The unlikely partnership between LRRK2 and α-synuclein in Parkinson's disease.The European journal of neuroscience, , Volume: 49, Issue:3, 2019
TIGAR inclusion pathology is specific for Lewy body diseases.Brain research, , 03-01, Volume: 1706, 2019
Understanding multifactorial architecture of Parkinson's disease: pathophysiology to management.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 40, Issue:1, 2019
Colonic neuropathology is not associated with autonomic dysfunction in Parkinson's disease.Parkinsonism & related disorders, , Volume: 61, 2019
Skin nerve α-synuclein deposits in a parkinsonian patient with heterozygous parkin mutation.Parkinsonism & related disorders, , Volume: 60, 2019
Path mediation analysis reveals GBA impacts Lewy body disease status by increasing α-synuclein levels.Neurobiology of disease, , Volume: 121, 2019
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis.Acta neuropathologica, , Volume: 137, Issue:1, 2019
Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein.Human molecular genetics, , 01-01, Volume: 28, Issue:1, 2019
Accelerated accumulation of retinal α-synuclein (pSer129) and tau, neuroinflammation, and autophagic dysregulation in a seeded mouse model of Parkinson's disease.Neurobiology of disease, , Volume: 121, 2019
Low-Dose Aspirin Upregulates Tyrosine Hydroxylase and Increases Dopamine Production in Dopaminergic Neurons: Implications for Parkinson's Disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 14, Issue:2, 2019
Alpha-Synuclein Nitration and Its Implications in Parkinson's Disease.ACS chemical neuroscience, , 02-20, Volume: 10, Issue:2, 2019
Interaction of α-Synuclein with ATP Synthase: Switching Role from Physiological to Pathological.ACS chemical neuroscience, , 01-16, Volume: 10, Issue:1, 2019
Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid - method comparison and round robin study.Journal of neurochemistry, , Volume: 149, Issue:1, 2019
Effects of Exercise and Ferulic Acid on Alpha Synuclein and Neuroprotective Heat Shock Protein 70 in An Experimental Model of Parkinsonism Disease.CNS & neurological disorders drug targets, , Volume: 18, Issue:2, 2019
Lack of central and peripheral nervous system synuclein pathology in R1441G Journal of neurology, neurosurgery, and psychiatry, , Volume: 90, Issue:7, 2019
Effect of Genistein on the Transgenic Journal of dietary supplements, , Volume: 16, Issue:5, 2019
Ammon's Horn 2 (CA2) of the Hippocampus: A Long-Known Region with a New Potential Role in Neurodegeneration.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, , Volume: 25, Issue:2, 2019
Differential insular cortex subregional vulnerability to α-synuclein pathology in Parkinson's disease and dementia with Lewy bodies.Neuropathology and applied neurobiology, , Volume: 45, Issue:3, 2019
Extracellular Alpha-Synuclein Oligomers Induce Parkin S-Nitrosylation: Relevance to Sporadic Parkinson's Disease Etiopathology.Molecular neurobiology, , Volume: 56, Issue:1, 2019
Down-regulation of natural resistance-associated macrophage protein-1 (Nramp1) is associated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)/1-methyl-4-phenylpyridinium (MPPNeuropathology and applied neurobiology, , Volume: 45, Issue:2, 2019
A neuroscience perspective of the gut theory of Parkinson's disease.The European journal of neuroscience, , Volume: 49, Issue:6, 2019
Enteric Pathologic Manifestations of Alpha-Synucleinopathies.Applied immunohistochemistry & molecular morphology : AIMM, , Volume: 27, Issue:7, 2019
Genetics of Parkinson's disease and related disorders.Journal of medical genetics, , Volume: 55, Issue:2, 2018
Microarray analysis of an synthetic α-synuclein induced cellular model reveals the expression profile of long non-coding RNA in Parkinson's disease.Brain research, , Jan-01, Volume: 1678, 2018
Alpha-synuclein dimerization in erythrocytes of patients with genetic and non-genetic forms of Parkinson's Disease.Neuroscience letters, , 04-13, Volume: 672, 2018
Order and disorder in the physiological membrane binding of α-synuclein.Current opinion in structural biology, , Volume: 48, 2018
Updates on immunity and inflammation in Parkinson disease pathology.Journal of neuroscience research, , Volume: 96, Issue:3, 2018
Molecular mechanisms of α-synuclein and GBA1 in Parkinson's disease.Cell and tissue research, , Volume: 373, Issue:1, 2018
Dexamethasone Inhibits Copper-Induced Alpha-Synuclein Aggregation by a Metallothionein-Dependent Mechanism.Neurotoxicity research, , Volume: 33, Issue:2, 2018
Levels of α- and β-synuclein regulate cellular susceptibility to toxicity from α-synuclein oligomers.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 32, Issue:2, 2018
Effect of optogenetic modulation on entopeduncular input affects thalamic discharge and behavior in an AAV2-α-synuclein-induced hemiparkinson rat model.Neuroscience letters, , Jan-01, Volume: 662, 2018
Intercellular transfer of pathogenic α-synuclein by extracellular vesicles is induced by the lipid peroxidation product 4-hydroxynonenal.Neurobiology of aging, , Volume: 61, 2018
Curcumin affords neuroprotection and inhibits α-synuclein aggregation in lipopolysaccharide-induced Parkinson's disease model.Inflammopharmacology, , Volume: 26, Issue:2, 2018
Manganese exposure: Linking down-regulation of miRNA-7 and miRNA-433 with α-synuclein overexpression and risk of idiopathic Parkinson's disease.Toxicology in vitro : an international journal published in association with BIBRA, , Volume: 46, 2018
How does parkinson's disease begin? Perspectives on neuroanatomical pathways, prions, and histology.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:1, 2018
Role of Sporadic Parkinson Disease Associated Mutations A18T and A29S in Enhanced α-Synuclein Fibrillation and Cytotoxicity.ACS chemical neuroscience, , 02-21, Volume: 9, Issue:2, 2018
The 200-year journey of Parkinson disease: Reflecting on the past and looking towards the future.Parkinsonism & related disorders, , Volume: 46 Suppl 1, 2018
Modulatory Role of Nurr1 Activation and Thrombin Inhibition in the Neuroprotective Effects of Dabigatran Etexilate in Rotenone-Induced Parkinson's Disease in Rats.Molecular neurobiology, , Volume: 55, Issue:5, 2018
α-Synuclein nonhuman primate models of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 125, Issue:3, 2018
Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson's disease.Neurobiology of disease, , Volume: 109, Issue:Pt B, 2018
The use of nonhuman primate models to understand processes in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 125, Issue:3, 2018
[Protective effect of curcumin on dopamine neurons in Parkinson's disease and its mechanism].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, , 05-25, Volume: 47, Issue:5, 2018
FLIM analysis of intracellular markers associated with the development of Parkinson's disease in cellular model.Physiological research, , 12-31, Volume: 67, Issue:Suppl 4, 2018
Parkinson's disease and Alzheimer's disease: a Mendelian randomization study.BMC medical genetics, , 12-31, Volume: 19, Issue:Suppl 1, 2018
Effects of Novel Calpain Inhibitors in Transgenic Animal Model of Parkinson's disease/dementia with Lewy bodies.Scientific reports, , 12-27, Volume: 8, Issue:1, 2018
MDSGene: Closing Data Gaps in Genotype-Phenotype Correlations of Monogenic Parkinson's Disease.Journal of Parkinson's disease, , Volume: 8, Issue:s1, 2018
Updating Our Definitions of Parkinson's Disease for a Molecular Age.Journal of Parkinson's disease, , Volume: 8, Issue:s1, 2018
The Gut and Parkinson's Disease: Hype or Hope?Journal of Parkinson's disease, , Volume: 8, Issue:s1, 2018
Parkinson Diseases in the 2020s and Beyond: Replacing Clinico-Pathologic Convergence With Systems Biology Divergence.Journal of Parkinson's disease, , Volume: 8, Issue:s1, 2018
miR-486-3p Influences the Neurotoxicity of a-Synuclein by Targeting the SIRT2 Gene and the Polymorphisms at Target Sites Contributing to Parkinson's Disease.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , Volume: 51, Issue:6, 2018
"Cell-addictive" dual-target traceable nanodrug for Parkinson's disease treatment via flotillins pathway.Theranostics, , Volume: 8, Issue:19, 2018
LRRK2 G2019S Mutation Inhibits Degradation of α-Synuclein in an In Vitro Model of Parkinson's Disease.Current medical science, , Volume: 38, Issue:6, 2018
Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson's disease and DLB.Proceedings of the National Academy of Sciences of the United States of America, , 12-18, Volume: 115, Issue:51, 2018
Distinct functional roles of Vps41-mediated neuroprotection in Alzheimer's and Parkinson's disease models of neurodegeneration.Human molecular genetics, , 12-15, Volume: 27, Issue:24, 2018
Parkinson-Associated SNCA Enhancer Variants Revealed by Open Chromatin in Mouse Dopamine Neurons.American journal of human genetics, , 12-06, Volume: 103, Issue:6, 2018
Mitochondrial activity in the frontal cortex area 8 and angular gyrus in Parkinson's disease and Parkinson's disease with dementia.Brain pathology (Zurich, Switzerland), , Volume: 28, Issue:1, 2018
Untangling alpha synuclein fibrils by graphene quantum dots.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:11, 2018
Effects of different force fields on the structural character of α synuclein β-hairpin peptide (35-56) in aqueous environment.Journal of biomolecular structure & dynamics, , Volume: 36, Issue:2, 2018
Resveratrol alleviates motor and cognitive deficits and neuropathology in the A53T α-synuclein mouse model of Parkinson's disease.Food & function, , Dec-13, Volume: 9, Issue:12, 2018
Cell Biology and Pathophysiology of α-Synuclein.Cold Spring Harbor perspectives in medicine, , 03-01, Volume: 8, Issue:3, 2018
Gene therapy approaches in the non-human primate model of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 125, Issue:3, 2018
α-Synuclein species as potential cerebrospinal fluid biomarkers for dementia with lewy bodies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:11, 2018
What is the Evidence That Parkinson's Disease is a Prion Disorder, Which Originates in the Gut?International journal of molecular sciences, , Nov-12, Volume: 19, Issue:11, 2018
Ratios of proteins in cerebrospinal fluid in Parkinson's disease cognitive decline: prospective study.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:11, 2018
Genetics of Synucleinopathies.Cold Spring Harbor perspectives in medicine, , 06-01, Volume: 8, Issue:6, 2018
The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson's disease.Scientific reports, , 11-01, Volume: 8, Issue:1, 2018
Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease.Science (New York, N.Y.), , 11-02, Volume: 362, Issue:6414, 2018
New Frontiers in Parkinson's Disease: From Genetics to the Clinic.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 10-31, Volume: 38, Issue:44, 2018
The vermiform appendix impacts the risk of developing Parkinson's disease.Science translational medicine, , 10-31, Volume: 10, Issue:465, 2018
Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice.Science translational medicine, , 10-31, Volume: 10, Issue:465, 2018
Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale.Nano letters, , 12-12, Volume: 18, Issue:12, 2018
Holothuria scabra extracts exhibit anti-Parkinson potential in C. elegans: A model for anti-Parkinson testing.Nutritional neuroscience, , Volume: 21, Issue:6, 2018
Gut-brain and brain-gut axis in Parkinson's disease models: Effects of a uridine and fish oil diet.Nutritional neuroscience, , Volume: 21, Issue:6, 2018
Possible Role of the Polyglutamine Elongation in Evolution of Amyloid-Related Evolvability.Journal of Huntington's disease, , Volume: 7, Issue:4, 2018
Alpha-Synuclein Toxicity on Protein Quality Control, Mitochondria and Endoplasmic Reticulum.Neurochemical research, , Volume: 43, Issue:12, 2018
Genotype-phenotype relations for the Parkinson's disease genes SNCA, LRRK2, VPS35: MDSGene systematic review.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:12, 2018
Lewy Body Dementia.Clinics in geriatric medicine, , Volume: 34, Issue:4, 2018
Cortical Thinning Associated with Age and CSF Biomarkers in Early Parkinson's Disease Is Modified by the SNCA rs356181 Polymorphism.Neuro-degenerative diseases, , Volume: 18, Issue:5-6, 2018
The Challenge of the Pathogenesis of Parkinson's Disease: Is Autoimmunity the Culprit?Frontiers in immunology, , Volume: 9, 2018
SNCA variants and alpha-synuclein level in CD45+ blood cells in Parkinson's disease.Journal of the neurological sciences, , 12-15, Volume: 395, 2018
Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age.Scientific reports, , 10-12, Volume: 8, Issue:1, 2018
NLRP3 Inflammasome-Related Proteins Are Upregulated in the Putamen of Patients With Multiple System Atrophy.Journal of neuropathology and experimental neurology, , 11-01, Volume: 77, Issue:11, 2018
C-terminal truncation exacerbates the aggregation and cytotoxicity of α-Synuclein: A vicious cycle in Parkinson's disease.Biochimica et biophysica acta. Molecular basis of disease, , Volume: 1864, Issue:12, 2018
123I-FP-CIT SPECT [(123) I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single photon emission computed tomography] Imaging in a p.A53T α-synuclein Parkinson's disease cohort versus Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:11, 2018
Using Patient-Derived Induced Pluripotent Stem Cells to Identify Parkinson's Disease-Relevant Phenotypes.Current neurology and neuroscience reports, , 10-04, Volume: 18, Issue:12, 2018
Alpha-synuclein staining in non-neural structures of the gastrointestinal tract is non-specific in Parkinson disease.Parkinsonism & related disorders, , Volume: 55, 2018
Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD.Molecular therapy : the journal of the American Society of Gene Therapy, , 11-07, Volume: 26, Issue:11, 2018
Time-Resolved NMR Analysis of Proteolytic α-Synuclein Processing in vitro and in cellulo.Proteomics, , Volume: 18, Issue:21-22, 2018
Skin α-synuclein deposits differ in clinical variants of synucleinopathy: an in vivo study.Scientific reports, , 09-24, Volume: 8, Issue:1, 2018
Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons.Proceedings of the National Academy of Sciences of the United States of America, , 10-09, Volume: 115, Issue:41, 2018
Feasibility and Safety of Multicenter Tissue and Biofluid Sampling for α-Synuclein in Parkinson's Disease: The Systemic Synuclein Sampling Study (S4).Journal of Parkinson's disease, , Volume: 8, Issue:4, 2018
A Cortical Pathogenic Theory of Parkinson's Disease.Neuron, , 09-19, Volume: 99, Issue:6, 2018
Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experiment.Acta neuropathologica communications, , 09-19, Volume: 6, Issue:1, 2018
α-Synuclein antibody 5G4 identifies manifest and prodromal Parkinson's disease in colonic mucosa.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:8, 2018
α-Synuclein strains in multiple system atrophy: A product of their environment?Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:8, 2018
Alpha-synuclein and the prion hypothesis in Parkinson's disease.Revue neurologique, , Volume: 174, Issue:9, 2018
Alpha-synuclein aggregates in the parotid gland of idiopathic REM sleep behavior disorder.Sleep medicine, , Volume: 52, 2018
α-synuclein expression from a single copy transgene increases sensitivity to stress and accelerates neuronal loss in genetic models of Parkinson's disease.Experimental neurology, , Volume: 310, 2018
Cerebrospinal fluid concentrations of inflammatory markers in Parkinson's disease and atypical parkinsonian disorders.Scientific reports, , 09-05, Volume: 8, Issue:1, 2018
Local and Global Dynamics in Intrinsically Disordered Synuclein.Angewandte Chemie (International ed. in English), , 11-12, Volume: 57, Issue:46, 2018
Is constipation in Parkinson's disease caused by gut or brain pathology?Parkinsonism & related disorders, , Volume: 55, 2018
Intestinal Pathology and Gut Microbiota Alterations in a Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Mouse Model of Parkinson's Disease.Neurochemical research, , Volume: 43, Issue:10, 2018
REM sleep behaviour disorder.Nature reviews. Disease primers, , 08-30, Volume: 4, Issue:1, 2018
Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson's disease.Journal of neuroinflammation, , Aug-30, Volume: 15, Issue:1, 2018
Separation and determination of alpha-synuclein monomeric and oligomeric species using two electrophoretic approaches.Electrophoresis, , Volume: 39, Issue:23, 2018
Modeling Parkinson's Disease Using Patient-specific Induced Pluripotent Stem Cells.Journal of Parkinson's disease, , Volume: 8, Issue:4, 2018
A comprehensive analysis of SNCA-related genetic risk in sporadic parkinson disease.Annals of neurology, , Volume: 84, Issue:1, 2018
Intranasal carnosine attenuates transcriptomic alterations and improves mitochondrial function in the Thy1-aSyn mouse model of Parkinson's disease.Molecular genetics and metabolism, , Volume: 125, Issue:3, 2018
Diagnostic biomarkers for Parkinson's disease at a glance: where are we?Journal of neural transmission (Vienna, Austria : 1996), , Volume: 125, Issue:10, 2018
Amyloid oligomerization of the Parkinson's disease related protein α-synuclein impacts on its curvature-membrane sensitivity.Journal of neurochemistry, , Volume: 147, Issue:4, 2018
Skin Nerve Phosphorylated α-Synuclein Deposits in Parkinson Disease With Orthostatic Hypotension.Journal of neuropathology and experimental neurology, , 10-01, Volume: 77, Issue:10, 2018
Detection of α-Synuclein in Saliva: The Importance of Preanalytical Assessment.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:6, 2018
Reply To: Detection of Alpha-Synuclein in Saliva: The Importance of Preanalytical Assessment.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:6, 2018
CRISPR/Cas9-Mediated Generation of Guangxi Bama Minipigs Harboring Three Mutations in α-Synuclein Causing Parkinson's Disease.Scientific reports, , 08-20, Volume: 8, Issue:1, 2018
An updated analysis with 45,078 subjects confirms the association between SNCA rs11931074 and Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 39, Issue:12, 2018
Yeast red pigment modifies cloned human α-synuclein pathogenesis in Parkinson disease models in Saccharomyces cerevisiae and Drosophila melanogaster.Neurochemistry international, , Volume: 120, 2018
14-3-3 Proteins Reduce Cell-to-Cell Transfer and Propagation of Pathogenic α-Synuclein.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 09-19, Volume: 38, Issue:38, 2018
The "when" and "where" of α-synucleinopathies: Insights from REM sleep behavior disorder.Neurology, , 09-04, Volume: 91, Issue:10, 2018
REM behavior disorder predicts motor progression and cognitive decline in Parkinson disease.Neurology, , 09-04, Volume: 91, Issue:10, 2018
Neuropsychiatric symptoms and α-Synuclein profile of patients with Parkinson's disease dementia, dementia with Lewy bodies and Alzheimer's disease.Journal of neurology, , Volume: 265, Issue:10, 2018
[Autonomic Dysfunction and Skin Biopsy in Dementia with Lewy Bodies].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 70, Issue:8, 2018
Dysregulation of bcl-2 enhanced rotenone-induced α-synuclein aggregation associated with autophagic pathways.Neuroreport, , 09-26, Volume: 29, Issue:14, 2018
Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson's disease brains with Lewy body pathology.Brain research, , 12-15, Volume: 1701, 2018
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells.Chembiochem : a European journal of chemical biology, , 10-04, Volume: 19, Issue:19, 2018
Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson's disease.Cell death & disease, , 07-26, Volume: 9, Issue:8, 2018
Synapsin III deficiency hampers α-synuclein aggregation, striatal synaptic damage and nigral cell loss in an AAV-based mouse model of Parkinson's disease.Acta neuropathologica, , Volume: 136, Issue:4, 2018
The Protective Role of Brain CYP2J in Parkinson's Disease Models.Oxidative medicine and cellular longevity, , Volume: 2018, 2018
LRRK2 activation in idiopathic Parkinson's disease.Science translational medicine, , 07-25, Volume: 10, Issue:451, 2018
Exercise as therapy for Parkinson's?Aging, , Jul-20, Volume: 10, Issue:7, 2018
The effect of truncation on prion-like properties of α-synuclein.The Journal of biological chemistry, , 09-07, Volume: 293, Issue:36, 2018
Determinants of dopaminergic neuron loss in Parkinson's disease.The FEBS journal, , Volume: 285, Issue:19, 2018
Regulation of membrane dynamics by Parkinson's disease-associated genes.Journal of genetics, , Volume: 97, Issue:3, 2018
Mitochondrial dysfunction in protein conformational disorders.Journal of genetics, , Volume: 97, Issue:3, 2018
Effect of cabergoline alginate nanocomposite on the transgenic Drosophila melanogaster model of Parkinson's disease.Toxicology mechanisms and methods, , Volume: 28, Issue:9, 2018
Parkinson's Disease: Alpha Synuclein, Heme Oxygenase and Biotherapeutic Countermeasures.Current pharmaceutical design, , Volume: 24, Issue:20, 2018
Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation.Journal of visualized experiments : JoVE, , 06-26, Issue:136, 2018
In vivo quantification of glial activation in minipigs overexpressing human α-synuclein.Synapse (New York, N.Y.), , Volume: 72, Issue:12, 2018
Identification of an Alternatively Spliced α-Synuclein Isoform That Generates a 41-Amino Acid N-Terminal Truncated Peptide, 41-syn: Role in Dopamine Homeostasis.ACS chemical neuroscience, , 12-19, Volume: 9, Issue:12, 2018
Gastrointestinal nervous system α-synuclein as a potential biomarker of Parkinson disease.Medicine, , Volume: 97, Issue:28, 2018
In Silico, in Vitro, and in Vivo Evaluation of New Candidates for α-Synuclein PET Imaging.Molecular pharmaceutics, , 08-06, Volume: 15, Issue:8, 2018
The lysosomal membrane protein LAMP2A promotes autophagic flux and prevents SNCA-induced Parkinson disease-like symptoms in the Drosophila brain.Autophagy, , Volume: 14, Issue:11, 2018
Graphene quantum dots prevent α-synucleinopathy in Parkinson's disease.Nature nanotechnology, , Volume: 13, Issue:9, 2018
Localized Induction of Wild-Type and Mutant Alpha-Synuclein Aggregation Reveals Propagation along Neuroanatomical Tracts.Journal of virology, , 09-15, Volume: 92, Issue:18, 2018
Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease.Acta neuropathologica communications, , 07-05, Volume: 6, Issue:1, 2018
Real-time determination of aggregated alpha-synuclein induced membrane disruption at neuroblastoma cells using scanning ion conductance microscopy.Faraday discussions, , 10-01, Volume: 210, Issue:0, 2018
Cryo-EM structure of alpha-synuclein fibrils.eLife, , 07-03, Volume: 7, 2018
Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity.Acta neuropathologica communications, , 07-02, Volume: 6, Issue:1, 2018
Lipid vesicles affect the aggregation of 4-hydroxy-2-nonenal-modified α-synuclein oligomers.Biochimica et biophysica acta. Molecular basis of disease, , Volume: 1864, Issue:9 Pt B, 2018
CircSNCA downregulation by pramipexole treatment mediates cell apoptosis and autophagy in Parkinson's disease by targeting miR-7.Aging, , Jun-28, Volume: 10, Issue:6, 2018
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.ACS chemical biology, , 08-17, Volume: 13, Issue:8, 2018
α-Synuclein and Polyunsaturated Fatty Acids: Molecular Basis of the Interaction and Implication in Neurodegeneration.Molecules (Basel, Switzerland), , Jun-25, Volume: 23, Issue:7, 2018
Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils.Proceedings of the National Academy of Sciences of the United States of America, , 07-10, Volume: 115, Issue:28, 2018
The enteric nervous system in PD: gateway, bystander victim, or source of solutions.Cell and tissue research, , Volume: 373, Issue:1, 2018
Evidence for dopaminergic axonal degeneration as an early pathological process in Parkinson's disease.Parkinsonism & related disorders, , Volume: 56, 2018
[GBA mutations and Parkinson's disease].Sheng li xue bao : [Acta physiologica Sinica], , Jun-25, Volume: 70, Issue:3, 2018
Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases.The FEBS journal, , Volume: 285, Issue:19, 2018
Alpha-synuclein delays mitophagy and targeting Miro rescues neuron loss in Parkinson's models.Acta neuropathologica, , Volume: 136, Issue:4, 2018
Somatic copy number gains of α-synuclein (SNCA) in Parkinson's disease and multiple system atrophy brains.Brain : a journal of neurology, , 08-01, Volume: 141, Issue:8, 2018
Safety and Tolerability of Multiple Ascending Doses of PRX002/RG7935, an Anti-α-Synuclein Monoclonal Antibody, in Patients With Parkinson Disease: A Randomized Clinical Trial.JAMA neurology, , 10-01, Volume: 75, Issue:10, 2018
Challenges in Passive Immunization Strategies to Treat Parkinson Disease.JAMA neurology, , 10-01, Volume: 75, Issue:10, 2018
Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to α-Synuclein Gain.Cell metabolism, , 10-02, Volume: 28, Issue:4, 2018
Nano-particle mediated inhibition of Parkinson's disease using computational biology approach.Scientific reports, , 06-15, Volume: 8, Issue:1, 2018
Generation of gene-corrected iPSC line from Parkinson's disease patient iPSC line with alpha-SNCA A53T mutation.Stem cell research, , Volume: 30, 2018
Parkinson's Disease Associated α-Synuclein Familial Mutants Promote Dopaminergic Neuronal Death in Drosophila melanogaster.ACS chemical neuroscience, , 11-21, Volume: 9, Issue:11, 2018
A single cell high content assay detects mitochondrial dysfunction in iPSC-derived neurons with mutations in SNCA.Scientific reports, , 06-13, Volume: 8, Issue:1, 2018
Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson's disease.Cell death & disease, , 06-13, Volume: 9, Issue:6, 2018
The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson's disease mouse model.Human molecular genetics, , 07-01, Volume: 27, Issue:13, 2018
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.Nature communications, , 06-12, Volume: 9, Issue:1, 2018
Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease.Nature medicine, , Volume: 24, Issue:7, 2018
Effect of capsaicin on the oxidative stress and dopamine content in the transgenic Drosophila model of Parkinson's disease.Acta biologica Hungarica, , Volume: 69, Issue:2, 2018
A novel link between trafficking and Lewy body disorders.The Lancet. Neurology, , Volume: 17, Issue:7, 2018
Prion-like propagation of pathology in Parkinson disease.Handbook of clinical neurology, , Volume: 153, 2018
In Vitro Analysis of α-Synuclein Amyloid Formation and Cross-Reactivity.Methods in molecular biology (Clifton, N.J.), , Volume: 1779, 2018
Generation and Characterization of Stable α-Synuclein Oligomers.Methods in molecular biology (Clifton, N.J.), , Volume: 1779, 2018
Preparation of α-Synuclein Amyloid Assemblies for Toxicity Experiments.Methods in molecular biology (Clifton, N.J.), , Volume: 1779, 2018
Rapid eye movement sleep behavior disorder and the link to alpha-synucleinopathies.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, , Volume: 129, Issue:8, 2018
Special issue "Parkinson's disease".Cell and tissue research, , Volume: 373, Issue:1, 2018
What autoantibodies tell us about the pathogenesis of Parkinson's disease: An Editorial for 'Measurements of auto-antibodies to α-synuclein in the serum and cerebral spinal fluids of patients with Parkinson's disease' on page 489.Journal of neurochemistry, , Volume: 145, Issue:6, 2018
Regional expression of genes mediating trans-synaptic alpha-synuclein transfer predicts regional atrophy in Parkinson disease.NeuroImage. Clinical, , Volume: 18, 2018
Co-aggregation of pro-inflammatory S100A9 with α-synuclein in Parkinson's disease: ex vivo and in vitro studies.Journal of neuroinflammation, , Jun-04, Volume: 15, Issue:1, 2018
Impaired Photic Entrainment of Spontaneous Locomotor Activity in Mice Overexpressing Human Mutant α-Synuclein.International journal of molecular sciences, , Jun-03, Volume: 19, Issue:6, 2018
Is Parkinson's disease a lysosomal disorder?Brain : a journal of neurology, , 08-01, Volume: 141, Issue:8, 2018
SNCA REP1 and Parkinson's disease.Neuroscience letters, , 08-24, Volume: 682, 2018
LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons.Acta neuropathologica communications, , 05-31, Volume: 6, Issue:1, 2018
Comparative Analysis of the Conformation, Aggregation, Interaction, and Fibril Morphologies of Human α-, β-, and γ-Synuclein Proteins.Biochemistry, , 07-03, Volume: 57, Issue:26, 2018
Linking Neuroinflammation and Neurodegeneration in Parkinson's Disease.Journal of immunology research, , Volume: 2018, 2018
Dopamine Transporter/α-Synuclein Complexes Are Altered in the Post Mortem Caudate Putamen of Parkinson's Disease: An In Situ Proximity Ligation Assay Study.International journal of molecular sciences, , May-30, Volume: 19, Issue:6, 2018
Beneficial Effects of Green Tea Catechins on Neurodegenerative Diseases.Molecules (Basel, Switzerland), , May-29, Volume: 23, Issue:6, 2018
Candidate biomarkers for Parkinson's disease.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 104, 2018
α-Synuclein aggregates in labial salivary glands of idiopathic rapid eye movement sleep behavior disorder.Sleep, , 08-01, Volume: 41, Issue:8, 2018
α-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's disease.The EMBO journal, , 06-15, Volume: 37, Issue:12, 2018
Identifying genes in Parkinson disease: state of the art.The Medical journal of Australia, , 05-21, Volume: 208, Issue:9, 2018
[Targeting Transcellular Transport of α-Synuclein for Developing Disease-Modifying Therapies for Synucleinopathy].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 70, Issue:5, 2018
[Multi-Organ Distribution of Alpha-Synuclein Pathology in Dementia with Lewy Bodies].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 70, Issue:5, 2018
Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in α-Synuclein Aggregation Disorders.EBioMedicine, , Volume: 31, 2018
Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve.Molecular neurodegeneration, , 05-11, Volume: 13, Issue:1, 2018
Different Structural Conformers of Monomeric α-Synuclein Identified after Lyophilizing and Freezing.Analytical chemistry, , 06-05, Volume: 90, Issue:11, 2018
Alpha Synuclein Fibrils Contain Multiple Binding Sites for Small Molecules.ACS chemical neuroscience, , 11-21, Volume: 9, Issue:11, 2018
α‑synuclein induces apoptosis of astrocytes by causing dysfunction of the endoplasmic reticulum‑Golgi compartment.Molecular medicine reports, , Volume: 18, Issue:1, 2018
Gangliosides, α-Synuclein, and Parkinson's Disease.Progress in molecular biology and translational science, , Volume: 156, 2018
A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia.Acta neuropathologica communications, , 05-10, Volume: 6, Issue:1, 2018
Phosphorylated α-synuclein in the retina is a biomarker of Parkinson's disease pathology severity.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:8, 2018
Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 06-19, Volume: 115, Issue:25, 2018
Toward deciphering the mechanistic role of variations in the Rep1 repeat site in the transcription regulation of SNCA gene.Neurogenetics, , Volume: 19, Issue:3, 2018
The cortical excitability profile of patients with the G209A SNCA mutation versus patients with sporadic Parkinson's disease: A transcranial magnetic stimulation study.Neurophysiologie clinique = Clinical neurophysiology, , Volume: 48, Issue:4, 2018
The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration.FEBS letters, , Volume: 592, Issue:23, 2018
The potential of zwitterionic nanoliposomes against neurotoxic alpha-synuclein aggregates in Parkinson's Disease.Nanoscale, , May-17, Volume: 10, Issue:19, 2018
(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis.Scientific reports, , 05-03, Volume: 8, Issue:1, 2018
Emerging disease-modifying strategies targeting α-synuclein for the treatment of Parkinson's disease.British journal of pharmacology, , Volume: 175, Issue:15, 2018
Structural characteristics and membrane interactions of tandem α-synuclein oligomers.Scientific reports, , 04-30, Volume: 8, Issue:1, 2018
An Enriched Environment Ameliorates Oxidative Stress and Olfactory Dysfunction in Parkinson's Disease with α-Synucleinopathy.Cell transplantation, , Volume: 27, Issue:5, 2018
Plasma α-synuclein and cognitive impairment in the Parkinson's Associated Risk Syndrome: A pilot study.Neurobiology of disease, , Volume: 116, 2018
Synergistic Amyloid Switch Triggered by Early Heterotypic Oligomerization of Intrinsically Disordered α-Synuclein and Tau.Journal of molecular biology, , 08-03, Volume: 430, Issue:16, 2018
Targeted Therapies for Parkinson's Disease: From Genetics to the Clinic.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:5, 2018
ɑ-Synuclein strains and seeding in Parkinson's disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences.Cell and tissue research, , Volume: 373, Issue:1, 2018
Alpha-synuclein mitochondrial interaction leads to irreversible translocation and complex I impairment.Archives of biochemistry and biophysics, , 08-01, Volume: 651, 2018
ELISA method to detect α-synuclein oligomers in cell and animal models.PloS one, , Volume: 13, Issue:4, 2018
Nitration of microtubules blocks axonal mitochondrial transport in a human pluripotent stem cell model of Parkinson's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 32, Issue:10, 2018
Detection of alpha-synuclein conformational variants from gastro-intestinal biopsy tissue as a potential biomarker for Parkinson's disease.Neuropathology and applied neurobiology, , Volume: 44, Issue:7, 2018
Inducible Alpha-Synuclein Expression Affects Human Neural Stem Cells' Behavior.Stem cells and development, , 07-15, Volume: 27, Issue:14, 2018
Structure and dynamics of the extended-helix state of alpha-synuclein: Intrinsic lability of the linker region.Protein science : a publication of the Protein Society, , Volume: 27, Issue:7, 2018
2-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease.Molecular neurobiology, , Volume: 55, Issue:12, 2018
Degradation of alpha-synuclein by dendritic cell factor 1 delays neurodegeneration and extends lifespan in Drosophila.Neurobiology of aging, , Volume: 67, 2018
Unravelling the inhibitory activity of Chlamydomonas reinhardtii sulfated polysaccharides against α-Synuclein fibrillation.Scientific reports, , 04-09, Volume: 8, Issue:1, 2018
Diabetes mellitus and Parkinson disease.Neurology, , 05-08, Volume: 90, Issue:19, 2018
Cx3cr1-deficiency exacerbates alpha-synuclein-A53T induced neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease.Glia, , Volume: 66, Issue:8, 2018
27-Hydroxycholesterol increases α-synuclein protein levels through proteasomal inhibition in human dopaminergic neurons.BMC neuroscience, , 04-03, Volume: 19, Issue:1, 2018
Targeting AMPK Signaling as a Neuroprotective Strategy in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 8, Issue:2, 2018
Iron Redox Chemistry Promotes Antiparallel Oligomerization of α-Synuclein.Journal of the American Chemical Society, , 04-18, Volume: 140, Issue:15, 2018
Sequestration of synaptic proteins by alpha-synuclein aggregates leading to neurotoxicity is inhibited by small peptide.PloS one, , Volume: 13, Issue:4, 2018
Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding.Protein science : a publication of the Protein Society, , Volume: 27, Issue:7, 2018
Paradoxical Effect of Trehalose on the Aggregation of α-Synuclein: Expedites Onset of Aggregation yet Reduces Fibril Load.ACS chemical neuroscience, , 06-20, Volume: 9, Issue:6, 2018
Pulsed Hydrogen-Deuterium Exchange Illuminates the Aggregation Kinetics of α-Synuclein, the Causative Agent for Parkinson's Disease.ACS chemical neuroscience, , 06-20, Volume: 9, Issue:6, 2018
Alpha-synuclein is present in dental calculus but not altered in Parkinson's disease patients in comparison to controls.Journal of neurology, , Volume: 265, Issue:6, 2018
Alpha-synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation.EMBO reports, , Volume: 19, Issue:5, 2018
Diabetes Mellitus as a Risk Factor for Parkinson's Disease: a Molecular Point of View.Molecular neurobiology, , Volume: 55, Issue:11, 2018
Acid ceramidase inhibition ameliorates α-synuclein accumulation upon loss of GBA1 function.Human molecular genetics, , 06-01, Volume: 27, Issue:11, 2018
Structural and Aggregation Properties of Alpha-Synuclein Linked to Phospholipase A2 Action.Protein and peptide letters, , Volume: 25, Issue:4, 2018
Phospholipase D1 downregulation by α-synuclein: Implications for neurodegeneration in Parkinson's disease.Biochimica et biophysica acta. Molecular and cell biology of lipids, , Volume: 1863, Issue:6, 2018
N-palmitoylethanolamide Prevents Parkinsonian Phenotypes in Aged Mice.Molecular neurobiology, , Volume: 55, Issue:11, 2018
The dopamine transporter: An unrecognized nexus for dysfunctional peripheral immunity and signaling in Parkinson's Disease.Brain, behavior, and immunity, , Volume: 70, 2018
Cerebrospinal fluid levels of alpha-synuclein in PARKINSON'S disease: Another long and winding road.Parkinsonism & related disorders, , Volume: 49, 2018
Modulation of β-glucocerebrosidase increases α-synuclein secretion and exosome release in mouse models of Parkinson's disease.Human molecular genetics, , 05-15, Volume: 27, Issue:10, 2018
Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy.Molecular neurodegeneration, , 03-15, Volume: 13, Issue:1, 2018
Early fine motor impairment and behavioral dysfunction in (Thy-1)-h[A30P] alpha-synuclein mice.Brain and behavior, , Volume: 8, Issue:3, 2018
Extracellular α-Synuclein Disrupts Membrane Nanostructure and Promotes S-Nitrosylation-Induced Neuronal Cell Death.Biomacromolecules, , 04-09, Volume: 19, Issue:4, 2018
Interaction of amyloidogenic proteins in pancreatic β cells from subjects with synucleinopathies.Acta neuropathologica, , Volume: 135, Issue:6, 2018
Detection of amyloid fibrils in Parkinson's disease using plasmonic chirality.Proceedings of the National Academy of Sciences of the United States of America, , 03-27, Volume: 115, Issue:13, 2018
Cytotoxic Oligomers and Fibrils Trapped in a Gel-like State of α-Synuclein Assemblies.Angewandte Chemie (International ed. in English), , 05-04, Volume: 57, Issue:19, 2018
Autonomic dysfunction in genetic forms of synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:3, 2018
Effects of Ginkgo Biloba Extract on A53T α-Synuclein Transgenic Mouse Models of Parkinson's Disease.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, , Volume: 45, Issue:2, 2018
Lysosomal response in relation to α-synuclein pathology differs between Parkinson's disease and multiple system atrophy.Neurobiology of disease, , Volume: 114, 2018
Correlations between CSF proteins and spontaneous neuronal activity in Parkinson's disease.Neuroscience letters, , 04-23, Volume: 673, 2018
Measurements of auto-antibodies to α-synuclein in the serum and cerebral spinal fluids of patients with Parkinson's disease.Journal of neurochemistry, , Volume: 145, Issue:6, 2018
Activating Autophagy as a Therapeutic Strategy for Parkinson's Disease.CNS drugs, , Volume: 32, Issue:1, 2018
Does Parkinson's disease start in the gut?Arquivos de neuro-psiquiatria, , Volume: 76, Issue:2, 2018
Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 03-13, Volume: 115, Issue:11, 2018
Analysis of age-related changes in psychosine metabolism in the human brain.PloS one, , Volume: 13, Issue:2, 2018
The concept of alpha-synuclein as a prion-like protein: ten years after.Cell and tissue research, , Volume: 373, Issue:1, 2018
Alpha-Synuclein Glycation and the Action of Anti-Diabetic Agents in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 8, Issue:1, 2018
[Symposium].Nihon saikingaku zasshi. Japanese journal of bacteriology, , Volume: 73, Issue:1, 2018
α-Synuclein Oligomers Induce a Unique Toxic Tau Strain.Biological psychiatry, , 10-01, Volume: 84, Issue:7, 2018
Locomotor differences in mice expressing wild-type human α-synuclein.Neurobiology of aging, , Volume: 65, 2018
Long Road to Ruin: Noradrenergic Dysfunction in Neurodegenerative Disease.Trends in neurosciences, , Volume: 41, Issue:4, 2018
α-synuclein (SNCA) but not dynamin 3 (DNM3) influences age at onset of leucine-rich repeat kinase 2 (LRRK2) Parkinson's disease in Spain.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:4, 2018
Lighting Up Alpha-synuclein Oligomers.EBioMedicine, , Volume: 29, 2018
Risk variants of the α-synuclein locus and REM sleep behavior disorder in Parkinson's disease: a genetic association study.BMC neurology, , Feb-21, Volume: 18, Issue:1, 2018
Shedding light on aberrant interactions - a review of modern tools for studying protein aggregates.The FEBS journal, , Volume: 285, Issue:19, 2018
Alpha-synuclein inhibits Snx3-retromer-mediated retrograde recycling of iron transporters in S. cerevisiae and C. elegans models of Parkinson's disease.Human molecular genetics, , 05-01, Volume: 27, Issue:9, 2018
From a Highly Disordered to a Metastable State: Uncovering Insights of α-Synuclein.ACS chemical neuroscience, , 05-16, Volume: 9, Issue:5, 2018
Selective cognitive impairment and hyposmia in p.A53T Neurology, , 03-06, Volume: 90, Issue:10, 2018
Relationship between cerebrospinal fluid biomarkers and structural brain network properties in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:3, 2018
Bimolecular Fluorescence Complementation of Alpha-synuclein Demonstrates its Oligomerization with Dopaminergic Phenotype in Mice.EBioMedicine, , Volume: 29, 2018
The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity.Molecular neurobiology, , Volume: 55, Issue:9, 2018
Naringenin Decreases α-Synuclein Expression and Neuroinflammation in MPTP-Induced Parkinson's Disease Model in Mice.Neurotoxicity research, , Volume: 33, Issue:3, 2018
Lack of pathogenic potential of peripheral α-synuclein aggregates from Parkinson's disease patients.Acta neuropathologica communications, , 02-08, Volume: 6, Issue:1, 2018
Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC.Acta neuropathologica communications, , 02-09, Volume: 6, Issue:1, 2018
Do subjects with minimal motor features have prodromal Parkinson disease?Annals of neurology, , Volume: 83, Issue:3, 2018
A noble pathological role for alpha-synuclein in triggering neurodegeneration of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:3, 2018
New Developments in Genetic rat models of Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:5, 2018
A peptide-display protein scaffold to facilitate single molecule force studies of aggregation-prone peptides.Protein science : a publication of the Protein Society, , Volume: 27, Issue:7, 2018
Acrolein-mediated neuronal cell death and alpha-synuclein aggregation: Implications for Parkinson's disease.Molecular and cellular neurosciences, , Volume: 88, 2018
Drp-1 dependent mitochondrial fragmentation and protective autophagy in dopaminergic SH-SY5Y cells overexpressing alpha-synuclein.Molecular and cellular neurosciences, , Volume: 88, 2018
Osmotic stress induced toxicity exacerbates Parkinson's associated effects via dysregulation of autophagy in transgenic C. elegans model.Cellular signalling, , Volume: 45, 2018
Evolution of cerebrospinal fluid total α-synuclein in Parkinson's disease.Parkinsonism & related disorders, , Volume: 49, 2018
Neuroprotective effects of voluntary running on cognitive dysfunction in an α-synuclein rat model of Parkinson's disease.Neurobiology of aging, , Volume: 65, 2018
Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson's Disease in Rodents.Journal of Parkinson's disease, , Volume: 8, Issue:2, 2018
Glucocerebrosidase and Parkinson Disease: Molecular, Clinical, and Therapeutic Implications.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, , Volume: 24, Issue:5, 2018
Insufficient evidence for pathogenicity of SNCA His50Gln (H50Q) in Parkinson's disease.Neurobiology of aging, , Volume: 64, 2018
Spectrum of abnormalities of sympathetic tyrosine hydroxylase and alpha-synuclein in chronic autonomic failure.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 28, Issue:2, 2018
Isoindole Linkages Provide a Pathway for DOPAL-Mediated Cross-Linking of α-Synuclein.Biochemistry, , 03-06, Volume: 57, Issue:9, 2018
Long-lasting pathological consequences of overexpression-induced α-synuclein spreading in the rat brain.Aging cell, , Volume: 17, Issue:2, 2018
Iron, Dopamine, and α-Synuclein Interactions in at-Risk Dopaminergic Neurons in Parkinson's Disease.Neuroscience bulletin, , Volume: 34, Issue:2, 2018
The fold preference and thermodynamic stability of α-synuclein fibrils is encoded in the non-amyloid-β component region.Physical chemistry chemical physics : PCCP, , Feb-07, Volume: 20, Issue:6, 2018
Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo.Scientific reports, , 01-24, Volume: 8, Issue:1, 2018
Insights into the Molecular Mechanisms of Alzheimer's and Parkinson's Diseases with Molecular Simulations: Understanding the Roles of Artificial and Pathological Missense Mutations in Intrinsically Disordered Proteins Related to Pathology.International journal of molecular sciences, , Jan-24, Volume: 19, Issue:2, 2018
Unveiling a Selective Mechanism for the Inhibition of α-Synuclein Aggregation by β-Synuclein.International journal of molecular sciences, , Jan-24, Volume: 19, Issue:2, 2018
Functional Characterization of Novel Circular RNA Molecule, circzip-2 and Its Synthesizing Gene zip-2 in C. elegans Model of Parkinson's Disease.Molecular neurobiology, , Volume: 55, Issue:8, 2018
Parkinson's disease from the gut.Brain research, , 08-15, Volume: 1693, Issue:Pt B, 2018
A tango for two: Dopamine and α-synuclein synergy may explain nigrostriatal degeneration in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:2, 2018
Genomic DNA levels of mutant alpha-synuclein correlate with non-motor symptoms in an A53T Parkinson's disease mouse model.Neurochemistry international, , Volume: 114, 2018
The relation between plasma α-synuclein level and clinical symptoms or signs of Parkinson's disease.Neurologia i neurochirurgia polska, , Volume: 52, Issue:2, 2018
Synapsin III is a key component of α-synuclein fibrils in Lewy bodies of PD brains.Brain pathology (Zurich, Switzerland), , Volume: 28, Issue:6, 2018
Neuroprotective Effects of Filgrastim in Rotenone-Induced Parkinson's Disease in Rats: Insights into its Anti-Inflammatory, Neurotrophic, and Antiapoptotic Effects.Molecular neurobiology, , Volume: 55, Issue:8, 2018
Genetics of Parkinson disease.Handbook of clinical neurology, , Volume: 147, 2018
Identification of new α-synuclein regulator by nontraditional drug development pipeline.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:3, 2018
Nigral depigmentation reflects monoamine exhaustion as initial step to Parkinson's disease.Medical hypotheses, , Volume: 110, 2018
GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers.Proceedings of the National Academy of Sciences of the United States of America, , 01-23, Volume: 115, Issue:4, 2018
Serum Mortalin Correlated with α-Synuclein as Serum Markers in Parkinson's Disease: A Pilot Study.Neuromolecular medicine, , Volume: 20, Issue:1, 2018
Pathological role of lipid interaction with α-synuclein in Parkinson's disease.Neurochemistry international, , Volume: 119, 2018
A refined concept: α-synuclein dysregulation disease.Neurochemistry international, , Volume: 119, 2018
α-Synuclein and Tau: Mitochondrial Kill Switches.Neuron, , 01-03, Volume: 97, Issue:1, 2018
Prion-like Propagation of α-Synuclein Is Regulated by the FcγRIIB-SHP-1/2 Signaling Pathway in Neurons.Cell reports, , 01-02, Volume: 22, Issue:1, 2018
Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide.Neuron, , 01-03, Volume: 97, Issue:1, 2018
Familial Parkinson's point mutation abolishes multiple system atrophy prion replication.Proceedings of the National Academy of Sciences of the United States of America, , 01-09, Volume: 115, Issue:2, 2018
Selective α-Synuclein Knockdown in Monoamine Neurons by Intranasal Oligonucleotide Delivery: Potential Therapy for Parkinson's Disease.Molecular therapy : the journal of the American Society of Gene Therapy, , 02-07, Volume: 26, Issue:2, 2018
Pathological histone acetylation in Parkinson's disease: Neuroprotection and inhibition of microglial activation through SIRT 2 inhibition.Neuroscience letters, , 02-14, Volume: 666, 2018
Trichloroethylene and Parkinson's Disease: Risk Assessment.Molecular neurobiology, , Volume: 55, Issue:7, 2018
Neuronal complex I deficiency occurs throughout the Parkinson's disease brain, but is not associated with neurodegeneration or mitochondrial DNA damage.Acta neuropathologica, , Volume: 135, Issue:3, 2018
Potential neuroprotective effect of androst-5-ene-3β, 17β-diol (ADIOL) on the striatum, and substantia nigra in Parkinson's disease rat model.Journal of cellular physiology, , Volume: 233, Issue:8, 2018
Immunologic treatment of Parkinson's disease.Immunotherapy, , Volume: 10, Issue:2, 2018
Reduced LRRK2 in association with retromer dysfunction in post-mortem brain tissue from LRRK2 mutation carriers.Brain : a journal of neurology, , 02-01, Volume: 141, Issue:2, 2018
Role of LRRK2 and SNCA in autosomal dominant Parkinson's disease in Turkey.Parkinsonism & related disorders, , Volume: 48, 2018
FKBP12-immunopositive inclusions in patients with α-synucleinopathies.Brain research, , 02-01, Volume: 1680, 2018
Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons.Neurobiology of disease, , Volume: 111, 2018
Expression of the DJ-1 protein in the serum of Chinese patients with Parkinson's disease.Neuroscience letters, , 02-05, Volume: 665, 2018
Alteration of autophagy-related proteins in peripheral blood mononuclear cells of patients with Parkinson's disease.Neurobiology of aging, , Volume: 63, 2018
LncRNA SNHG1 promotes α-synuclein aggregation and toxicity by targeting miR-15b-5p to activate SIAH1 in human neuroblastoma SH-SY5Y cells.Neurotoxicology, , Volume: 68, 2018
Suppression of autophagy in the brain of transgenic mice with overexpression of А53Т-mutant α-synuclein as an early event at synucleinopathy progression.Neuroscience letters, , 04-13, Volume: 672, 2018
Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype.Autophagy, , Volume: 14, Issue:1, 2018
Structural features of α-synuclein amyloid fibrils revealed by Raman spectroscopy.The Journal of biological chemistry, , 01-19, Volume: 293, Issue:3, 2018
Alpha-synuclein, Proteotoxicity and Parkinson's Disease: Search for Neuroprotective Therapy.Current neuropharmacology, , Volume: 16, Issue:7, 2018
Metals and Parkinson's Disease: Mechanisms and Biochemical Processes.Current medicinal chemistry, , Volume: 25, Issue:19, 2018
Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease.Behavioural brain research, , Feb-26, Volume: 339, 2018
Discovering the 3' UTR-mediated regulation of alpha-synuclein.Nucleic acids research, , Dec-15, Volume: 45, Issue:22, 2017
Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels.BMC neurology, , Nov-15, Volume: 17, Issue:1, 2017
Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles.Scientific reports, , 11-08, Volume: 7, Issue:1, 2017
Synthesis and biological evaluation of novel radioiodinated benzimidazole derivatives for imaging α-synuclein aggregates.Bioorganic & medicinal chemistry, , 12-15, Volume: 25, Issue:24, 2017
c-Abl and Parkinson's Disease: Mechanisms and Therapeutic Potential.Journal of Parkinson's disease, , Volume: 7, Issue:4, 2017
Eye movements in genetic parkinsonisms affecting the α-synuclein, PARK9, and manganese network.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, , Volume: 128, Issue:12, 2017
Sleep fragmentation and Parkinson's disease pathology in older adults without Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:12, 2017
Synuclein and dopamine: the Bonnie and Clyde of Parkinson's disease.Nature neuroscience, , 10-26, Volume: 20, Issue:11, 2017
Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease.Scientific reports, , 10-20, Volume: 7, Issue:1, 2017
Breathing new life into an old target: pulmonary disease drugs for Parkinson's disease therapy.Genome medicine, , 10-19, Volume: 9, Issue:1, 2017
CCAAT/Enhancer binding protein β silencing mitigates glial activation and neurodegeneration in a rat model of Parkinson's disease.Scientific reports, , 10-19, Volume: 7, Issue:1, 2017
Brain monoamine oxidase B and A in human parkinsonian dopamine deficiency disorders.Brain : a journal of neurology, , Sep-01, Volume: 140, Issue:9, 2017
Comparison of the in vivo induction and transmission of α-synuclein pathology by mutant α-synuclein fibril seeds in transgenic mice.Human molecular genetics, , 12-15, Volume: 26, Issue:24, 2017
Prying into the Prion Hypothesis for Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 10-11, Volume: 37, Issue:41, 2017
α-Synuclein impairs ferritinophagy in the retinal pigment epithelium: Implications for retinal iron dyshomeostasis in Parkinson's disease.Scientific reports, , 10-09, Volume: 7, Issue:1, 2017
FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling.Stem cell reports, , 11-14, Volume: 9, Issue:5, 2017
Therapeutic approaches to target alpha-synuclein pathology.Experimental neurology, , Volume: 298, Issue:Pt B, 2017
Alpha-synuclein, epigenetics, mitochondria, metabolism, calcium traffic, & circadian dysfunction in Parkinson's disease. An integrated strategy for management.Ageing research reviews, , Volume: 40, 2017
Reply to "Can STN DBS protect both nigral somata and innervation of the striatum?"Annals of neurology, , Volume: 82, Issue:5, 2017
Can STN DBS protect both nigral somata and innervation of the striatum?Annals of neurology, , Volume: 82, Issue:5, 2017
Randomized CRISPR-Cas Transcriptional Perturbation Screening Reveals Protective Genes against Alpha-Synuclein Toxicity.Molecular cell, , Oct-05, Volume: 68, Issue:1, 2017
Is trehalose an autophagic inducer? Unraveling the roles of non-reducing disaccharides on autophagic flux and alpha-synuclein aggregation.Cell death & disease, , 10-05, Volume: 8, Issue:10, 2017
Alpha-synuclein induces the unfolded protein response in Parkinson's disease SNCA triplication iPSC-derived neurons.Human molecular genetics, , 11-15, Volume: 26, Issue:22, 2017
A ventral glomerular deficit in Parkinson's disease revealed by whole olfactory bulb reconstruction.Brain : a journal of neurology, , Oct-01, Volume: 140, Issue:10, 2017
C-Terminal Truncated α-Synuclein Fibrils Contain Strongly Twisted β-Sheets.Journal of the American Chemical Society, , 11-01, Volume: 139, Issue:43, 2017
Getting in charge of β-synuclein fibrillation.The Journal of biological chemistry, , 09-29, Volume: 292, Issue:39, 2017
Absence of SNCA polymorphisms in Pakistani Parkinsons disease patients.JPMA. The Journal of the Pakistan Medical Association, , Volume: 67, Issue:10, 2017
Proteasome impairment by α-synuclein.PloS one, , Volume: 12, Issue:9, 2017
NCEH-1 modulates cholesterol metabolism and protects against α-synuclein toxicity in a C. elegans model of Parkinson's disease.Human molecular genetics, , 10-01, Volume: 26, Issue:19, 2017
Loss of MicroRNA-7 Regulation Leads to α-Synuclein Accumulation and Dopaminergic Neuronal Loss In Vivo.Molecular therapy : the journal of the American Society of Gene Therapy, , 10-04, Volume: 25, Issue:10, 2017
Age-Dependent Alpha-Synuclein Accumulation and Phosphorylation in the Enteric Nervous System in a Transgenic Mouse Model of Parkinson's Disease.Neuroscience bulletin, , Volume: 33, Issue:5, 2017
TrkB neurotrophic activities are blocked by α-synuclein, triggering dopaminergic cell death in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 10-03, Volume: 114, Issue:40, 2017
Insights into the structural biology of Gaucher disease.Experimental neurology, , Volume: 298, Issue:Pt B, 2017
Fundamental limit of alpha-synuclein pathology in gastrointestinal biopsy as a pathologic biomarker of Parkinson's disease: Comparison with surgical specimens.Parkinsonism & related disorders, , Volume: 44, 2017
Beyond L-DOPA: hope for Parkinson's treatment and diagnosis.EBioMedicine, , Volume: 23, 2017
Parkinson disease: Asthma drug could protect against PD.Nature reviews. Neurology, , Volume: 13, Issue:11, 2017
Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells.Human molecular genetics, , 09-15, Volume: 26, Issue:18, 2017
Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson's disease?Acta neuropathologica communications, , 09-13, Volume: 5, Issue:1, 2017
Modeling Parkinson's disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain.Proceedings of the National Academy of Sciences of the United States of America, , 09-26, Volume: 114, Issue:39, 2017
REM sleep behavior disorder is related to enteric neuropathology in Parkinson disease.Neurology, , Oct-10, Volume: 89, Issue:15, 2017
Mitochondrial dynamics in Parkinson's disease: a role for α-synuclein?Disease models & mechanisms, , 09-01, Volume: 10, Issue:9, 2017
Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease.Science (New York, N.Y.), , 09-22, Volume: 357, Issue:6357, 2017
Diagnostic utility of cerebrospinal fluid α-synuclein in Parkinson's disease: A systematic review and meta-analysis.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:10, 2017
The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome.PloS one, , Volume: 12, Issue:9, 2017
Vaccination strategies in tauopathies and synucleinopathies.Journal of neurochemistry, , Volume: 143, Issue:5, 2017
Alpha-Synuclein to the Rescue: Immune Cell Recruitment by Alpha-Synuclein during Gastrointestinal Infection.Journal of innate immunity, , Volume: 9, Issue:5, 2017
Discoidin domain receptor inhibition reduces neuropathology and attenuates inflammation in neurodegeneration models.Journal of neuroimmunology, , 10-15, Volume: 311, 2017
Effects of small-molecule amyloid modulators on a Drosophila model of Parkinson's disease.PloS one, , Volume: 12, Issue:9, 2017
The Medicinal Chemistry of Natural and Semisynthetic Compounds against Parkinson's and Huntington's Diseases.ACS chemical neuroscience, , 11-15, Volume: 8, Issue:11, 2017
β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson's disease.Science (New York, N.Y.), , 09-01, Volume: 357, Issue:6354, 2017
α-Synucleinopathy in the Human Amygdala in Parkinson Disease: Differential Vulnerability of Somatostatin- and Parvalbumin-Expressing Neurons.Journal of neuropathology and experimental neurology, , Sep-01, Volume: 76, Issue:9, 2017
In utero delivery of rAAV2/9 induces neuronal expression of the transgene in the brain: towards new models of Parkinson's disease.Gene therapy, , Volume: 24, Issue:12, 2017
Association between SNCA rs2736990 polymorphism and Parkinson's disease: a meta-analysis.Neuroscience letters, , Sep-29, Volume: 658, 2017
Cerebrospinal fluid β-glucocerebrosidase activity is reduced in parkinson's disease patients.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:10, 2017
Epigenetic approach to early-onset Parkinson's disease: low methylation status of SNCA and PARK2 promoter regions.Neurological research, , Volume: 39, Issue:11, 2017
Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages.Scientific reports, , 08-21, Volume: 7, Issue:1, 2017
Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson's disease.Journal of neuroinflammation, , Aug-18, Volume: 14, Issue:1, 2017
Bioinorganic Chemistry of Parkinson's Disease: Affinity and Structural Features of Cu(I) Binding to the Full-Length β-Synuclein Protein.Inorganic chemistry, , Sep-05, Volume: 56, Issue:17, 2017
A Systems Model of Parkinson's Disease Using Biochemical Systems Theory.Omics : a journal of integrative biology, , Volume: 21, Issue:8, 2017
Alpha-synuclein ferrireductase activity is detectible in vivo, is altered in Parkinson's disease and increases the neurotoxicity of DOPAL.Molecular and cellular neurosciences, , Volume: 85, 2017
Alpha-synuclein oligomers: a new hope.Acta neuropathologica, , Volume: 134, Issue:6, 2017
Preclinical development of a vaccine against oligomeric alpha-synuclein based on virus-like particles.PloS one, , Volume: 12, Issue:8, 2017
Alpha-synuclein triggers T-cell response. Is Parkinson's disease an autoimmune disorder?Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:9, 2017
Homologous HSV1 and alpha-synuclein peptides stimulate a T cell response in Parkinson's disease.Journal of neuroimmunology, , 09-15, Volume: 310, 2017
A meta-analysis and review examining a possible role for oxidative stress and singlet oxygen in diverse diseases.The Biochemical journal, , 08-02, Volume: 474, Issue:16, 2017
Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation.Journal of neuroinflammation, , 08-02, Volume: 14, Issue:1, 2017
Experimental animal models of Parkinson's disease: A transition from assessing symptomatology to α-synuclein targeted disease modification.Experimental neurology, , Volume: 298, Issue:Pt B, 2017
Small-Molecule-Induced Soluble Oligomers of α-Synuclein with Helical Structure.Chemistry (Weinheim an der Bergstrasse, Germany), , Sep-21, Volume: 23, Issue:53, 2017
Differential role of CSF fatty acid binding protein 3, α-synuclein, and Alzheimer's disease core biomarkers in Lewy body disorders and Alzheimer's dementia.Alzheimer's research & therapy, , Jul-28, Volume: 9, Issue:1, 2017
Animal models of α-synucleinopathy for Parkinson disease drug development.Nature reviews. Neuroscience, , Volume: 18, Issue:9, 2017
Parkinsonian features in aging GFAP.HMOX1 transgenic mice overexpressing human HO-1 in the astroglial compartment.Neurobiology of aging, , Volume: 58, 2017
Early synaptic dysfunction induced by α-synuclein in a rat model of Parkinson's disease.Scientific reports, , 07-25, Volume: 7, Issue:1, 2017
New Therapeutic Strategies for Lewy Body Dementias.Current neurology and neuroscience reports, , Volume: 17, Issue:9, 2017
A user's guide for α-synuclein biomarker studies in biological fluids: Perianalytical considerations.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:8, 2017
α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading.Acta neuropathologica, , Volume: 134, Issue:5, 2017
O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson's disease.Molecular brain, , 07-19, Volume: 10, Issue:1, 2017
The Golgi-localized, gamma ear-containing, ARF-binding (GGA) protein family alters alpha synuclein (α-syn) oligomerization and secretion.Aging, , 07-15, Volume: 9, Issue:7, 2017
A unique glycan-isoform of transferrin in cerebrospinal fluid: A potential diagnostic marker for neurological diseases.Biochimica et biophysica acta. General subjects, , Volume: 1861, Issue:10, 2017
A pH-dependent switch promotes β-synuclein fibril formation via glutamate residues.The Journal of biological chemistry, , 09-29, Volume: 292, Issue:39, 2017
Secretory carrier membrane protein 5 is an autophagy inhibitor that promotes the secretion of α-synuclein via exosome.PloS one, , Volume: 12, Issue:7, 2017
αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson's disease.Scientific reports, , 07-11, Volume: 7, Issue:1, 2017
Neuroprotective effect of α-mangostin on mitochondrial dysfunction and α-synuclein aggregation in rotenone-induced model of Parkinson's disease in differentiated SH-SY5Y cells.Journal of Asian natural products research, , Volume: 19, Issue:8, 2017
Role of Apolipoproteins and α-Synuclein in Parkinson's Disease.Journal of molecular neuroscience : MN, , Volume: 62, Issue:3-4, 2017
Imaging neuroinflammation to monitor α-synucleinopathy.The Lancet. Neurology, , Volume: 16, Issue:10, 2017
Physico-Pathologic Mechanisms Involved in Neurodegeneration: Misfolded Protein-Plasma Membrane Interactions.Neuron, , Jul-05, Volume: 95, Issue:1, 2017
Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy.Molecular neurodegeneration, , 07-04, Volume: 12, Issue:1, 2017
Parkinson's Disease: Basic Pathomechanisms and a Clinical Overview.Advances in neurobiology, , Volume: 15, 2017
Parkinson's disease; the hibernating spore hypothesis.Medical hypotheses, , Volume: 104, 2017
Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease.Nature structural & molecular biology, , Volume: 24, Issue:8, 2017
The Role of Lipids Interacting with α-Synuclein in the Pathogenesis of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 7, Issue:3, 2017
Brain infusion of α-synuclein oligomers induces motor and non-motor Parkinson's disease-like symptoms in mice.Behavioural brain research, , 08-30, Volume: 333, 2017
Homozygous alpha-synuclein p.A53V in familial Parkinson's disease.Neurobiology of aging, , Volume: 57, 2017
A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity.Journal of innate immunity, , Volume: 9, Issue:5, 2017
CADPS2 gene expression is oppositely regulated by LRRK2 and alpha-synuclein.Biochemical and biophysical research communications, , 08-26, Volume: 490, Issue:3, 2017
T cells from patients with Parkinson's disease recognize α-synuclein peptides.Nature, , 06-29, Volume: 546, Issue:7660, 2017
Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson's disease.Scientific reports, , 06-20, Volume: 7, Issue:1, 2017
α-Synuclein aggregation modulation: an emerging approach for the treatment of Parkinson's disease.Future medicinal chemistry, , Volume: 9, Issue:10, 2017
Striatal changes underlie MPEP-mediated suppression of the acquisition and expression of pramipexole-induced place preference in an alpha-synuclein rat model of Parkinson's disease.Journal of psychopharmacology (Oxford, England), , Volume: 31, Issue:10, 2017
Pressure effects on α-synuclein amyloid fibrils: An experimental investigation on their dissociation and reversible nature.Archives of biochemistry and biophysics, , 08-01, Volume: 627, 2017
The implication of neuronimmunoendocrine (NIE) modulatory network in the pathophysiologic process of Parkinson's disease.Cellular and molecular life sciences : CMLS, , Volume: 74, Issue:20, 2017
Design, synthesis, immunocytochemistry evaluation, and molecular docking investigation of several 4-aminopyridine derivatives as potential neuroprotective agents for treating Parkinson's disease.Bioorganic chemistry, , Volume: 73, 2017
Novel evidence associates higher plasma α-synuclein levels and cognitive impairment in Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry, , Volume: 88, Issue:10, 2017
A loss of Pdxk model of Parkinson disease in Drosophila can be suppressed by Buffy.BMC research notes, , Jun-12, Volume: 10, Issue:1, 2017
Discovery, validation and optimization of cerebrospinal fluid biomarkers for use in Parkinson's disease.Expert review of molecular diagnostics, , Volume: 17, Issue:8, 2017
Autoimmune antibody decline in Parkinson's disease and Multiple System Atrophy; a step towards immunotherapeutic strategies.Molecular neurodegeneration, , 06-07, Volume: 12, Issue:1, 2017
Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson's disease.Molecular neurodegeneration, , 06-07, Volume: 12, Issue:1, 2017
Modeling Parkinson's disease with induced pluripotent stem cells harboring α-synuclein mutations.Brain pathology (Zurich, Switzerland), , Volume: 27, Issue:4, 2017
Treatment with diphenyl-pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death.Proceedings of the National Academy of Sciences of the United States of America, , 06-20, Volume: 114, Issue:25, 2017
Cutaneous Alpha-Synuclein From Paraffin Embedded Autopsy Specimens in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 7, Issue:3, 2017
Mesenchymal Stem Cells Stabilize Axonal Transports for Autophagic Clearance of α-Synuclein in Parkinsonian Models.Stem cells (Dayton, Ohio), , Volume: 35, Issue:8, 2017
Cystatin C as a potential therapeutic mediator against Parkinson's disease via VEGF-induced angiogenesis and enhanced neuronal autophagy in neurovascular units.Cell death & disease, , 06-01, Volume: 8, Issue:6, 2017
Zeroing in on neurodegenerative α-synuclein.Nature reviews. Drug discovery, , 05-31, Volume: 16, Issue:6, 2017
AlphaLISA detection of alpha-synuclein in the cerebrospinal fluid and its potential application in Parkinson's disease diagnosis.Protein & cell, , Volume: 8, Issue:9, 2017
Plasma α-synuclein predicts cognitive decline in Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry, , Volume: 88, Issue:10, 2017
Tau/α-synuclein ratio and inflammatory proteins in Parkinson's disease: An exploratory study.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:7, 2017
Structural genomic variations and Parkinson's disease.Minerva medica, , Volume: 108, Issue:5, 2017
Membrane Trafficking Illuminates a Path to Parkinson's Disease.The Tohoku journal of experimental medicine, , Volume: 242, Issue:1, 2017
Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production.Cellular and molecular life sciences : CMLS, , Volume: 74, Issue:15, 2017
Treadmill exercise produces neuroprotective effects in a murine model of Parkinson's disease by regulating the TLR2/MyD88/NF-κB signaling pathway.Neuroscience, , 07-25, Volume: 356, 2017
Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins.Acta neuropathologica, , Volume: 134, Issue:4, 2017
Cellular models as tools for the study of the role of alpha-synuclein in Parkinson's disease.Experimental neurology, , Volume: 298, Issue:Pt B, 2017
Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 06-14, Volume: 37, Issue:24, 2017
Alpha-Synuclein mRNA Is Not Increased in Sporadic PD and Alpha-Synuclein Accumulation Does Not Block GDNF Signaling in Parkinson's Disease and Disease Models.Molecular therapy : the journal of the American Society of Gene Therapy, , 10-04, Volume: 25, Issue:10, 2017
Glucocerebrosidase deficiency in dopaminergic neurons induces microglial activation without neurodegeneration.Human molecular genetics, , 07-15, Volume: 26, Issue:14, 2017
Survival and Causes of Death Among People With Clinically Diagnosed Synucleinopathies With Parkinsonism: A Population-Based Study.JAMA neurology, , 07-01, Volume: 74, Issue:7, 2017
Validation of electrochemiluminescence assays for highly sensitive and reproducible quantification of α-synuclein in cerebrospinal fluid.Bioanalysis, , Volume: 9, Issue:8, 2017
High expression levels of the D686N Parkinson's disease mutation in VPS35 induces α-synuclein-dependent toxicity in yeast.Molecular medicine reports, , Volume: 16, Issue:1, 2017
O-GlcNAc modification inhibits the calpain-mediated cleavage of α-synuclein.Bioorganic & medicinal chemistry, , 09-15, Volume: 25, Issue:18, 2017
Enteric alpha-synuclein pathology in LRRK2-G2019S Parkinson's disease.Parkinsonism & related disorders, , Volume: 40, 2017
Higher levels of myelin phospholipids in brains of neuronal α-Synuclein transgenic mice precede myelin loss.Acta neuropathologica communications, , 05-08, Volume: 5, Issue:1, 2017
The critical role of Nramp1 in degrading α-synuclein oligomers in microglia under iron overload condition.Neurobiology of disease, , Volume: 104, 2017
Expression signatures of long non-coding RNA in the substantia nigra of pre-symptomatic mouse model of Parkinson's disease.Behavioural brain research, , 07-28, Volume: 331, 2017
Subthalamic nucleus deep brain stimulation is neuroprotective in the A53T α-synuclein Parkinson's disease rat model.Annals of neurology, , Volume: 81, Issue:6, 2017
Novel Benzothiazole Derivatives as Fluorescent Probes for Detection of β-Amyloid and α-Synuclein Aggregates.ACS chemical neuroscience, , 08-16, Volume: 8, Issue:8, 2017
TMEM230 in Parkinson's disease.Neurobiology of aging, , Volume: 56, 2017
Parkinson disease: Antibodies reveal age of Lewy pathology in PD.Nature reviews. Neurology, , Volume: 13, Issue:6, 2017
Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage.Molecular and cellular neurosciences, , Volume: 82, 2017
Deregulation of α-synuclein in Parkinson's disease: Insight from epigenetic structure and transcriptional regulation of SNCA.Progress in neurobiology, , Volume: 154, 2017
Involvement of the cerebellum in Parkinson disease and dementia with Lewy bodies.Annals of neurology, , Volume: 81, Issue:6, 2017
Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.Neurochemistry international, , Volume: 109, 2017
Genetic analysis of α-synuclein 3' untranslated region and its corresponding microRNAs in relation to Parkinson's disease compared to dementia with Lewy bodies.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 13, Issue:11, 2017
Evidence from spatial pattern analysis for the anatomical spread of α-synuclein pathology in Parkinson's disease dementia.Folia neuropathologica, , Volume: 55, Issue:1, 2017
Imaging genetics approach to Parkinson's disease and its correlation with clinical score.Scientific reports, , 04-21, Volume: 7, 2017
Lewy pathological study on α-synuclein in gastrointestinal tissues of prodromal Parkinson's disease.European review for medical and pharmacological sciences, , Volume: 21, Issue:7, 2017
Defective synaptic connectivity and axonal neuropathology in a human iPSC-based model of familial Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 05-02, Volume: 114, Issue:18, 2017
Derivation of mouse embryonic stem cell lines from tyrosine hydroxylase reporter mice crossed with a human SNCA transgenic mouse model of Parkinson's disease.Stem cell research, , Volume: 19, 2017
In vitro α-synuclein neurotoxicity and spreading among neurons and astrocytes using Lewy body extracts from Parkinson disease brains.Neurobiology of disease, , Volume: 103, 2017
SNCA 3'UTR genetic variants in patients with Parkinson's disease and REM sleep behavior disorder.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 38, Issue:7, 2017
Ubiquitin and Parkinson's disease through the looking glass of genetics.The Biochemical journal, , 04-13, Volume: 474, Issue:9, 2017
Spine Topographical Distribution of Skin α-Synuclein Deposits in Idiopathic Parkinson Disease.Journal of neuropathology and experimental neurology, , May-01, Volume: 76, Issue:5, 2017
Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson's disease.Neuropathology and applied neurobiology, , Volume: 43, Issue:7, 2017
Lack of spontaneous age-related brain pathology in Octodon degus: a reappraisal of the model.Scientific reports, , 04-04, Volume: 7, 2017
A novel tool for monitoring endogenous alpha-synuclein transcription by NanoLuciferase tag insertion at the 3'end using CRISPR-Cas9 genome editing technique.Scientific reports, , 04-04, Volume: 8, 2017
A sensitive assay reveals structural requirements for α-synuclein fibril growth.The Journal of biological chemistry, , 06-02, Volume: 292, Issue:22, 2017
Motor deficits and beta oscillations are dissociable in an alpha-synuclein model of Parkinson's disease.The European journal of neuroscience, , Volume: 46, Issue:3, 2017
Disparate genes come together: Spatial and genetic screens point to disruptions in vesicle trafficking and mRNA metabolism in synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:6, 2017
Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage.Human molecular genetics, , 06-15, Volume: 26, Issue:12, 2017
The Systemic Synuclein Sampling Study: toward a biomarker for Parkinson's disease.Biomarkers in medicine, , Volume: 11, Issue:4, 2017
Interaction of LRRK2 and α-Synuclein in Parkinson's Disease.Advances in neurobiology, , Volume: 14, 2017
α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt CaActa neuropathologica, , Volume: 134, Issue:1, 2017
MOAG-4 promotes the aggregation of α-synuclein by competing with self-protective electrostatic interactions.The Journal of biological chemistry, , 05-19, Volume: 292, Issue:20, 2017
Parkinson disease.Nature reviews. Disease primers, , Mar-23, Volume: 3, 2017
Decrease in Aβ42 predicts dopa-resistant gait progression in early Parkinson disease.Neurology, , Apr-18, Volume: 88, Issue:16, 2017
DJ-1, a Parkinson's disease related protein, aggregates under denaturing conditions and co-aggregates with α-synuclein through hydrophobic interaction.Biochimica et biophysica acta. General subjects, , Volume: 1861, Issue:7, 2017
Association between gene polymorphism and depression in Parkinson's disease: A case-control study.Journal of the neurological sciences, , Apr-15, Volume: 375, 2017
Structural variants in SNCA gene and the implication to synucleinopathies.Current opinion in genetics & development, , Volume: 44, 2017
An alpha-synuclein MRM assay with diagnostic potential for Parkinson's disease and monitoring disease progression.Proteomics. Clinical applications, , Volume: 11, Issue:7-8, 2017
LTB-Syn: a recombinant immunogen for the development of plant-made vaccines against synucleinopathies.Planta, , Volume: 245, Issue:6, 2017
Protein aggregation and neurodegeneration in prototypical neurodegenerative diseases: Examples of amyloidopathies, tauopathies and synucleinopathies.Progress in neurobiology, , Volume: 155, 2017
Lewy Bodies and the Mechanisms of Neuronal Cell Death in Parkinson's Disease and Dementia with Lewy Bodies.Brain pathology (Zurich, Switzerland), , Volume: 27, Issue:1, 2017
Spinal cord stimulation improves forelimb use in an alpha-synuclein animal model of Parkinson's disease.The International journal of neuroscience, , Volume: 127, Issue:1, 2017
Familial Mutations and Post-translational Modifications of UCH-L1 in Parkinson's Disease and Neurodegenerative Disorders.Current protein & peptide science, , Volume: 18, Issue:7, 2017
Expression of Aquaporin 1 and Aquaporin 4 in the Temporal Neocortex of Patients with Parkinson's Disease.Brain pathology (Zurich, Switzerland), , Volume: 27, Issue:2, 2017
LRRK2 and Parkinson's Disease: From Lack of Structure to Gain of Function.Current protein & peptide science, , Volume: 18, Issue:7, 2017
Involvement of Gaucher Disease Mutations in Parkinson Disease.Current protein & peptide science, , Volume: 18, Issue:7, 2017
Alteration of Structure and Aggregation of α-Synuclein by Familial Parkinson's Disease Associated Mutations.Current protein & peptide science, , Volume: 18, Issue:7, 2017
Cerebrospinal fluid biomarkers for Parkinson's disease - a systematic review.Acta neurologica Scandinavica, , Volume: 135, Issue:1, 2017
mTOR Signaling in Parkinson's Disease.Neuromolecular medicine, , Volume: 19, Issue:1, 2017
Traffic jams and the complex role of α-Synuclein aggregation in Parkinson disease.Small GTPases, , 04-03, Volume: 8, Issue:2, 2017
Expression of the Parkinson's Disease-Associated Gene Alpha-Synuclein is Regulated by the Neuronal Cell Fate Determinant TRIM32.Molecular neurobiology, , Volume: 54, Issue:6, 2017
Sirtuins as modifiers of Parkinson's disease pathology.Journal of neuroscience research, , Volume: 95, Issue:4, 2017
α-Synuclein-carrying extracellular vesicles in Parkinson's disease: deadly transmitters.Acta neurologica Belgica, , Volume: 117, Issue:1, 2017
Expanding role of molecular chaperones in regulating α-synuclein misfolding; implications in Parkinson's disease.Cellular and molecular life sciences : CMLS, , Volume: 74, Issue:4, 2017
Common structural features of toxic intermediates from α-synuclein and GroES fibrillogenesis detected using cryogenic coherent X-ray diffraction imaging.Journal of biochemistry, , Volume: 161, Issue:1, 2017
Behavior of α-synuclein-drug complexes during nanopore analysis with a superimposed AC field.Electrophoresis, , Volume: 38, Issue:2, 2017
The yin and yang of α-synuclein-associated epigenetics in Parkinson's disease.Brain : a journal of neurology, , Apr-01, Volume: 140, Issue:4, 2017
ER Stress Induced by Tunicamycin Triggers α-Synuclein Oligomerization, Dopaminergic Neurons Death and Locomotor Impairment: a New Model of Parkinson's Disease.Molecular neurobiology, , Volume: 54, Issue:8, 2017
Challenging drug target for Parkinson's disease: Pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins.Biochimica et biophysica acta. Molecular basis of disease, , Volume: 1863, Issue:1, 2017
α-synuclein aggregation and its modulation.International journal of biological macromolecules, , Volume: 100, 2017
Mulberry fruit ameliorates Parkinson's-disease-related pathology by reducing α-synuclein and ubiquitin levels in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model.The Journal of nutritional biochemistry, , Volume: 39, 2017
Finding the 'Guilty' Gene Variant of Sporadic Parkinson's Disease Via CRISPR/Cas9.Neuroscience bulletin, , Volume: 33, Issue:1, 2017
Oligomeric α-synuclein and glucocerebrosidase activity levels in GBA-associated Parkinson's disease.Neuroscience letters, , 01-01, Volume: 636, 2017
Modulation of Parkinson's Disease Associated Protein Rescues Alzheimer's Disease Degeneration.Journal of Alzheimer's disease : JAD, , Volume: 55, Issue:1, 2017
α-Synuclein in the colon and premotor markers of Parkinson disease in neurologically normal subjects.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 38, Issue:1, 2017
Synucleinopathies: common features and hippocampal manifestations.Cellular and molecular life sciences : CMLS, , Volume: 74, Issue:8, 2017
SNCA mutation p.Ala53Glu is derived from a common founder in the Finnish population.Neurobiology of aging, , Volume: 50, 2017
Lack of RAB39B mutations in early-onset and familial Parkinson's disease in a Taiwanese cohort.Neurobiology of aging, , Volume: 50, 2017
Treatments and compositions targeting α-synuclein: a patent review (2010-2016).Expert opinion on therapeutic patents, , Volume: 27, Issue:4, 2017
Modelling idiopathic Parkinson disease as a complex illness can inform incidence rate in healthy adults: the PThe European journal of neuroscience, , Volume: 45, Issue:1, 2017
An order in Lewy body disorders: Retrograde degeneration in hyperbranching axons as a fundamental structural template accounting for focal/multifocal Lewy body disease.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 37, Issue:2, 2017
Antibodies against the C-terminus of α-synuclein modulate its fibrillation.Biophysical chemistry, , Volume: 220, 2017
Pathological α-synuclein exacerbates the progression of Parkinson's disease through microglial activation.Toxicology letters, , Jan-04, Volume: 265, 2017
Aging modifies the effect of GCH1 RS11158026 on DAT uptake and Parkinson's disease clinical severity.Neurobiology of aging, , Volume: 50, 2017
Relationship between the plasma levels of neurodegenerative proteins and motor subtypes of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 124, Issue:3, 2017
Toll-like receptor 2 is increased in neurons in Parkinson's disease brain and may contribute to alpha-synuclein pathology.Acta neuropathologica, , Volume: 133, Issue:2, 2017
Hypothalamic α-synuclein and its relation to weight loss and autonomic symptoms in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:2, 2017
Toxic effects of human and rodent variants of alpha-synuclein in vivo.The European journal of neuroscience, , Volume: 45, Issue:4, 2017
Copy number variability in Parkinson's disease: assembling the puzzle through a systems biology approach.Human genetics, , Volume: 136, Issue:1, 2017
Robust graft survival and normalized dopaminergic innervation do not obligate recovery in a Parkinson disease patient.Annals of neurology, , Volume: 81, Issue:1, 2017
Comparison of neuropathology in Parkinson's disease subjects with and without deep brain stimulation.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:2, 2017
D-Ala2-GIP-glu-PAL is neuroprotective in a chronic Parkinson's disease mouse model and increases BNDF expression while reducing neuroinflammation and lipid peroxidation.European journal of pharmacology, , Feb-15, Volume: 797, 2017
Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders.Pharmacology & therapeutics, , Volume: 172, 2017
Differential copper binding to alpha-synuclein and its disease-associated mutants affect the aggregation and amyloid formation.Biochimica et biophysica acta. General subjects, , Volume: 1861, Issue:2, 2017
Conformation-Specific Detection of α-Synuclein: The Search for a Biomarker in Parkinson Disease.JAMA neurology, , 02-01, Volume: 74, Issue:2, 2017
Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid.JAMA neurology, , Feb-01, Volume: 74, Issue:2, 2017
Extracts from two ubiquitous Mediterranean plants ameliorate cellular and animal models of neurodegenerative proteinopathies.Neuroscience letters, , 01-18, Volume: 638, 2017
The Transcellular Propagation and Intracellular Trafficking of α-Synuclein.Cold Spring Harbor perspectives in medicine, , Sep-01, Volume: 7, Issue:9, 2017
Early and progressive microstructural brain changes in mice overexpressing human α-Synuclein detected by diffusion kurtosis imaging.Brain, behavior, and immunity, , Volume: 61, 2017
The FBXO7 homologue nutcracker and binding partner PI31 in Drosophila melanogaster models of Parkinson's disease.Genome, , Volume: 60, Issue:1, 2017
Nurr1 overexpression exerts neuroprotective and anti-inflammatory roles via down-regulating CCL2 expression in both in vivo and in vitro Parkinson's disease models.Biochemical and biophysical research communications, , Jan-22, Volume: 482, Issue:4, 2017
Effects of α-synuclein on axonal transport.Neurobiology of disease, , Volume: 105, 2017
MicroRNA expressing profiles in A53T mutant alpha-synuclein transgenic mice and Parkinsonian.Oncotarget, , Jan-03, Volume: 8, Issue:1, 2017
Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis.The Lancet. Neurology, , Volume: 16, Issue:1, 2017
Bilateral upregulation of α-synuclein expression in the mouse substantia nigra by intracranial rotenone treatment.Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, , Volume: 69, Issue:2, 2017
Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation.Brain research bulletin, , Volume: 133, 2017
Impulse control disorder, lysosomal malfunction and ATP13A2 insufficiency in Parkinsonism.Clinical and experimental pharmacology & physiology, , Volume: 44, Issue:2, 2017
New evidence comes to light: How is α-synuclein aggregation related to mitochondrial protein import in Parkinson's disease?Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:1, 2017
Analysis of sheep α-synuclein provides a molecular strategy for the reduction of fibrillation.Biochimica et biophysica acta. Proteins and proteomics, , Volume: 1865, Issue:3, 2017
Nrf2 mitigates LRRK2- and α-synuclein-induced neurodegeneration by modulating proteostasis.Proceedings of the National Academy of Sciences of the United States of America, , 01-31, Volume: 114, Issue:5, 2017
[Neuropathology and pathophysiology of Parkinson's disease: Focus on α-synuclein].Presse medicale (Paris, France : 1983), , Volume: 46, Issue:2 Pt 1, 2017
Inhibition by Multifunctional Magnetic Nanoparticles Loaded with Alpha-Synuclein RNAi Plasmid in a Parkinson's Disease Model.Theranostics, , Volume: 7, Issue:2, 2017
Mutant α-Synuclein Overexpression Induces Stressless Pacemaking in Vagal Motoneurons at Risk in Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 01-04, Volume: 37, Issue:1, 2017
Distinct pattern of enteric phospho-alpha-synuclein aggregates and gene expression profiles in patients with Parkinson's disease.Acta neuropathologica communications, , 01-05, Volume: 5, Issue:1, 2017
Treadmill exercise alleviates motor deficits and improves mitochondrial import machinery in an MPTP-induced mouse model of Parkinson's disease.Experimental gerontology, , Volume: 89, 2017
Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils.Redox biology, , Volume: 11, 2017
The Search for a Peripheral Biopsy Indicator of α-Synuclein Pathology for Parkinson Disease.Journal of neuropathology and experimental neurology, , 01-01, Volume: 76, Issue:1, 2017
Familial Mutations May Switch Conformational Preferences in α-Synuclein Fibrils.ACS chemical neuroscience, , 04-19, Volume: 8, Issue:4, 2017
Ferroptosis and cell death mechanisms in Parkinson's disease.Neurochemistry international, , Volume: 104, 2017
Nanoparticle standards for immuno-based quantitation of α-synuclein oligomers in diagnostics of Parkinson's disease and other synucleinopathies.Clinica chimica acta; international journal of clinical chemistry, , Volume: 466, 2017
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.Proceedings of the National Academy of Sciences of the United States of America, , 02-07, Volume: 114, Issue:6, 2017
Selective neuronal vulnerability in Parkinson disease.Nature reviews. Neuroscience, , 01-20, Volume: 18, Issue:2, 2017
Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.Disease models & mechanisms, , 05-01, Volume: 10, Issue:5, 2017
Impact of high cholesterol in a Parkinson's disease model: Prevention of lysosomal leakage versus stimulation of α-synuclein aggregation.European journal of cell biology, , Volume: 96, Issue:2, 2017
Evidence for Intramolecular Antiparallel Beta-Sheet Structure in Alpha-Synuclein Fibrils from a Combination of Two-Dimensional Infrared Spectroscopy and Atomic Force Microscopy.Scientific reports, , 01-23, Volume: 7, 2017
Stimulation of synaptoneurosome glutamate release by monomeric and fibrillated α-synuclein.Journal of neuroscience research, , Volume: 95, Issue:9, 2017
Biochemical analysis of α-synuclein extracted from control and Parkinson's disease colonic biopsies.Neuroscience letters, , 02-22, Volume: 641, 2017
The effect of α-synuclein on gliosis and IL-1α, TNFα, IFNγ, TGFβ expression in murine brain.Pharmacological reports : PR, , Volume: 69, Issue:2, 2017
In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons.Cell systems, , 02-22, Volume: 4, Issue:2, 2017
The Contribution of Neural plasticity, , Volume: 2017, 2017
Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing.Genome biology, , 01-30, Volume: 18, Issue:1, 2017
Autophagic modulation by rosuvastatin prevents rotenone-induced neurotoxicity in an in vitro model of Parkinson's disease.Neuroscience letters, , 03-06, Volume: 642, 2017
Early start of progressive motor deficits in Line 61 α-synuclein transgenic mice.BMC neuroscience, , 01-31, Volume: 18, Issue:1, 2017
Auxilin Underlies Progressive Locomotor Deficits and Dopaminergic Neuron Loss in a Drosophila Model of Parkinson's Disease.Cell reports, , 01-31, Volume: 18, Issue:5, 2017
Nicotine slows down oligomerisation of α-synuclein and ameliorates cytotoxicity in a yeast model of Parkinson's disease.Biochimica et biophysica acta. Molecular basis of disease, , Volume: 1863, Issue:6, 2017
Alpha-synuclein and iron: two keys unlocking Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 124, Issue:8, 2017
α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies.Nature medicine, , Feb-07, Volume: 23, Issue:2, 2017
Hypomethylation of intron1 of α-synuclein gene does not correlate with Parkinson's disease.Molecular brain, , 02-07, Volume: 10, Issue:1, 2017
Dermal phospho-alpha-synuclein deposits confirm REM sleep behaviour disorder as prodromal Parkinson's disease.Acta neuropathologica, , Volume: 133, Issue:4, 2017
Laminar degeneration of frontal and temporal cortex in Parkinson disease dementia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 38, Issue:4, 2017
Epidemiology, environmental risk factors and genetics of Parkinson's disease.Presse medicale (Paris, France : 1983), , Volume: 46, Issue:2 Pt 1, 2017
TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation.Proceedings of the National Academy of Sciences of the United States of America, , 02-28, Volume: 114, Issue:9, 2017
The LRRK2-macroautophagy axis and its relevance to Parkinson's disease.Biochemical Society transactions, , 02-08, Volume: 45, Issue:1, 2017
[Disease-Modifying Therapy for Parkinson's Disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 69, Issue:2, 2017
Neuropathology of PARK14 is identical to idiopathic Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:5, 2017
A Human Neural Crest Stem Cell-Derived Dopaminergic Neuronal Model Recapitulates Biochemical Abnormalities in GBA1 Mutation Carriers.Stem cell reports, , 03-14, Volume: 8, Issue:3, 2017
Whether the dissociation between toxicity and α-synuclein inclusion will be a possible therapy for Parkinson's disease or not?Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:2, 2017
Targeting α-Synuclein as a therapy for Parkinson's disease: The battle begins.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:2, 2017
Nucleobindin 1 binds to multiple types of pre-fibrillar amyloid and inhibits fibrillization.Scientific reports, , 02-21, Volume: 7, 2017
Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models.Proceedings of the National Academy of Sciences of the United States of America, , 03-07, Volume: 114, Issue:10, 2017
α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson's disease patients.Scientific reports, , 02-23, Volume: 7, 2017
From Yeast to Patients: The Audacity and Vision of Susan Lindquist.Cell systems, , 02-22, Volume: 4, Issue:2, 2017
α-Synuclein structural features inhibit harmful polyunsaturated fatty acid oxidation, suggesting roles in neuroprotection.The Journal of biological chemistry, , 04-28, Volume: 292, Issue:17, 2017
Polyphenols in combination with β-cyclodextrin can inhibit and disaggregate α-synuclein amyloids under cell mimicking conditions: A promising therapeutic alternative.Biochimica et biophysica acta. Proteins and proteomics, , Volume: 1865, Issue:5, 2017
Potential Modes of Intercellular α-Synuclein Transmission.International journal of molecular sciences, , Feb-22, Volume: 18, Issue:2, 2017
Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease.Proceedings of the National Academy of Sciences of the United States of America, , 03-14, Volume: 114, Issue:11, 2017
Urinary dysfunction in early de novo patients with Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:6, 2017
High-Throughput Screening Methodology to Identify Alpha-Synuclein Aggregation Inhibitors.International journal of molecular sciences, , Mar-02, Volume: 18, Issue:3, 2017
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.PLoS biology, , Volume: 15, Issue:3, 2017
Phosphorylated α-synuclein immunoreactivity in nerve fibers from minor salivary glands in Parkinson's disease.Parkinsonism & related disorders, , Volume: 38, 2017
Immunochemical Detection of α-Synuclein Autoantibodies in Parkinson's Disease: Correlation between Plasma and Cerebrospinal Fluid Levels.ACS chemical neuroscience, , 06-21, Volume: 8, Issue:6, 2017
Mechanisms of Parkinson's disease-related proteins in mediating secondary brain damage after cerebral ischemia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 37, Issue:6, 2017
The Identification of Alpha-Synuclein as the First Parkinson Disease Gene.Journal of Parkinson's disease, , Volume: 7, Issue:s1, 2017
The Synucleinopathies: Twenty Years On.Journal of Parkinson's disease, , Volume: 7, Issue:s1, 2017
The Birth of the Modern Era of Parkinson's Disease Genetics.Journal of Parkinson's disease, , Volume: 7, Issue:s1, 2017
α-Synuclein promotes dilation of the exocytotic fusion pore.Nature neuroscience, , Volume: 20, Issue:5, 2017
Aggregation of α-Synuclein in the Gonadal Tissue of 2 Patients With Parkinson Disease.JAMA neurology, , 05-01, Volume: 74, Issue:5, 2017
The Cleavage Effect of Mesenchymal Stem Cell and Its Derived Matrix Metalloproteinase-2 on Extracellular α-Synuclein Aggregates in Parkinsonian Models.Stem cells translational medicine, , Volume: 6, Issue:3, 2017
Alpha-Synuclein Disease Mutations Are Structurally Defective and Locally Affect Membrane Binding.Journal of the American Chemical Society, , 03-29, Volume: 139, Issue:12, 2017
Investigation of the effects of carbon-based nanomaterials on A53T alpha-synuclein aggregation using a whole-cell recombinant biosensor.International journal of nanomedicine, , Volume: 12, 2017
Running wheel exercise reduces α-synuclein aggregation and improves motor and cognitive function in a transgenic mouse model of Parkinson's disease.PloS one, , Volume: 12, Issue:12, 2017
EGCG-mediated Protection of the Membrane Disruption and Cytotoxicity Caused by the 'Active Oligomer' of α-Synuclein.Scientific reports, , 12-20, Volume: 7, Issue:1, 2017
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers.Science (New York, N.Y.), , 12-15, Volume: 358, Issue:6369, 2017
microRNAs in Parkinson's Disease: From Pathogenesis to Novel Diagnostic and Therapeutic Approaches.International journal of molecular sciences, , Dec-13, Volume: 18, Issue:12, 2017
Unraveling amyloid formation paths of Parkinson's disease protein α-synuclein triggered by anionic vesicles.Quarterly reviews of biophysics, , Volume: 50, 2017
FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome.Proceedings of the National Academy of Sciences of the United States of America, , 12-26, Volume: 114, Issue:52, 2017
Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes.Journal of neuroinflammation, , Dec-11, Volume: 14, Issue:1, 2017
SUMOylation and ubiquitination reciprocally regulate α-synuclein degradation and pathological aggregation.Proceedings of the National Academy of Sciences of the United States of America, , 12-12, Volume: 114, Issue:50, 2017
Morphological analysis of mitochondria for evaluating the toxicity of α-synuclein in transgenic mice and isolated preparations by atomic force microscopy.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 96, 2017
α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration.Acta neuropathologica communications, , Nov-21, Volume: 5, Issue:1, 2017
Anti-Parkinsonian effects of β-amyrin are regulated via LGG-1 involved autophagy pathway in Caenorhabditis elegans.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Dec-01, Volume: 36, 2017
Formation and Implications of Alpha-Synuclein Radical in Maneb- and Paraquat-Induced Models of Parkinson's Disease.Molecular neurobiology, , Volume: 53, Issue:5, 2016
Treatment with Trehalose Prevents Behavioral and Neurochemical Deficits Produced in an AAV α-Synuclein Rat Model of Parkinson's Disease.Molecular neurobiology, , Volume: 53, Issue:4, 2016
Pedunculopontine cell loss and protein aggregation direct microglia activation in parkinsonian rats.Brain structure & function, , Volume: 221, Issue:4, 2016
Can we use peripheral tissue biopsies to diagnose Parkinson's disease? A review of the literature.European journal of neurology, , Volume: 23, Issue:2, 2016
Unfolded protein response is activated in Lewy body dementias.Neuropathology and applied neurobiology, , Volume: 42, Issue:4, 2016
Mathematical models of α-synuclein transport in axons.Computer methods in biomechanics and biomedical engineering, , Volume: 19, Issue:5, 2016
Active immunization therapies for Parkinson's disease and multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
New insights into cellular α-synuclein homeostasis in health and disease.Current opinion in neurobiology, , Volume: 36, 2016
Oligomeric α-synuclein and β-amyloid variants as potential biomarkers for Parkinson's and Alzheimer's diseases.The European journal of neuroscience, , Volume: 43, Issue:1, 2016
Neuropathology of α-synuclein propagation and braak hypothesis.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Skin biopsies in the differential diagnosis of parkinsonism: are we ready for simplified protocols?Brain : a journal of neurology, , Volume: 139, Issue:Pt 1, 2016
Reply: Skin biopsies in the differential diagnosis of parkinsonism: are we ready for simplified protocols?Brain : a journal of neurology, , Volume: 139, Issue:Pt 1, 2016
Brain region-dependent differential expression of alpha-synuclein.The Journal of comparative neurology, , Apr-15, Volume: 524, Issue:6, 2016
Combination therapies: The next logical Step for the treatment of synucleinopathies?Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Alpha-Synuclein Produces Early Behavioral Alterations via Striatal Cholinergic Synaptic Dysfunction by Interacting With GluN2D N-Methyl-D-Aspartate Receptor Subunit.Biological psychiatry, , Mar-01, Volume: 79, Issue:5, 2016
Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.Acta neuropathologica, , Volume: 131, Issue:1, 2016
Biological confounders for the values of cerebrospinal fluid proteins in Parkinson's disease and related disorders.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Formation and Characterization of α-Synuclein Oligomers.Methods in molecular biology (Clifton, N.J.), , Volume: 1345, 2016
Fluorescence Methods for Unraveling Oligomeric Amyloid Intermediates.Methods in molecular biology (Clifton, N.J.), , Volume: 1345, 2016
Cell Models to Study Cell-to-Cell Transmission of α-Synuclein.Methods in molecular biology (Clifton, N.J.), , Volume: 1345, 2016
Inhibition effects of tanshinone on the aggregation of α-synuclein.Food & function, , Volume: 7, Issue:1, 2016
Altered α-synuclein, parkin, and synphilin isoform levels in multiple system atrophy brains.Journal of neurochemistry, , Volume: 136, Issue:1, 2016
Non-Amyloid-β Component of Human α-Synuclein Oligomers Induces Formation of New Aβ Oligomers: Insight into the Mechanisms That Link Parkinson's and Alzheimer's Diseases.ACS chemical neuroscience, , Jan-20, Volume: 7, Issue:1, 2016
Immunotherapeutic Approaches Targeting Amyloid-β, α-Synuclein, and Tau for the Treatment of Neurodegenerative Disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 13, Issue:1, 2016
Modulating the Amyloidogenesis of α-Synuclein.Current neuropharmacology, , Volume: 14, Issue:3, 2016
Analysis of the genetic variability in Parkinson's disease from Southern Spain.Neurobiology of aging, , Volume: 37, 2016
Conformational ensemble of human α-synuclein physiological form predicted by molecular simulations.Physical chemistry chemical physics : PCCP, , Feb-17, Volume: 18, Issue:8, 2016
Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease.Antioxidants & redox signaling, , Mar-01, Volume: 24, Issue:7, 2016
Immunomodulation as a neuroprotective and therapeutic strategy for Parkinson's disease.Current opinion in pharmacology, , Volume: 26, 2016
Age-dependent defects of alpha-synuclein oligomer uptake in microglia and monocytes.Acta neuropathologica, , Volume: 131, Issue:3, 2016
Variants in GBA, SNCA, and MAPT influence Parkinson disease risk, age at onset, and progression.Neurobiology of aging, , Volume: 37, 2016
Skin nerve misfolded α-synuclein in pure autonomic failure and Parkinson disease.Annals of neurology, , Volume: 79, Issue:2, 2016
Membrane lipids as therapeutic targets for Parkinson's disease: a possible link between Lewy pathology and membrane lipids.Expert opinion on therapeutic targets, , Volume: 20, Issue:11, 2016
Current disease modifying approaches to treat Parkinson's disease.Cellular and molecular life sciences : CMLS, , Volume: 73, Issue:7, 2016
Sorting out release, uptake and processing of alpha-synuclein during prion-like spread of pathology.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Value of cerebrospinal fluid α-synuclein species as biomarker in Parkinson's diagnosis and prognosis.Biomarkers in medicine, , Volume: 10, Issue:1, 2016
Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies.Brain : a journal of neurology, , Volume: 139, Issue:Pt 2, 2016
Brain aging and Parkinson's disease: New therapeutic approaches using drug delivery systems.Maturitas, , Volume: 84, 2016
Broad neutralization of calcium-permeable amyloid pore channels with a chimeric Alzheimer/Parkinson peptide targeting brain gangliosides.Biochimica et biophysica acta, , Volume: 1862, Issue:2, 2016
Review: Sporadic Parkinson's disease: development and distribution of α-synuclein pathology.Neuropathology and applied neurobiology, , Volume: 42, Issue:1, 2016
Alpha-synuclein in gastric and colonic mucosa in Parkinson's disease: Limited role as a biomarker.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Nociceptin/Orphanin FQ Inhibits the Survival and Axon Growth of Midbrain Dopaminergic Neurons Through a p38-MAPK Dependent Mechanism.Molecular neurobiology, , Volume: 53, Issue:10, 2016
A new biomarker for Parkinson's disease?Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:1, 2016
Development of Nonviral Vectors Targeting the Brain as a Therapeutic Approach For Parkinson's Disease and Other Brain Disorders.Molecular therapy : the journal of the American Society of Gene Therapy, , Volume: 24, Issue:4, 2016
Interaction of α-synuclein with biomembranes in Parkinson's disease--role of cardiolipin.Progress in lipid research, , Volume: 61, 2016
Development of Passive Immunotherapies for Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Alpha synuclein dimers and oligomers are increased in overexpressing conditions in vitro and in vivo.Molecular and cellular neurosciences, , Volume: 71, 2016
Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization.The Journal of biological chemistry, , Feb-26, Volume: 291, Issue:9, 2016
Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology.Acta neuropathologica, , Volume: 131, Issue:3, 2016
Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model by targeting α-synuclein abnormalities in the substantia nigra.Toxicology letters, , Jan-22, Volume: 243, 2016
The analysis of association between SNCA, HUSEYO and CSMD1 gene variants and Parkinson's disease in Iranian population.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 37, Issue:5, 2016
α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.Human molecular genetics, , Mar-15, Volume: 25, Issue:6, 2016
Synphilin-1 attenuates mutant LRRK2-induced neurodegeneration in Parkinson's disease models.Human molecular genetics, , Feb-15, Volume: 25, Issue:4, 2016
Lewy body pathology involves the olfactory cells in Parkinson's disease and related disorders.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:1, 2016
Therapeutic approaches in Parkinson's disease and related disorders.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Review: The spectrum of clinical features seen with alpha synuclein pathology.Neuropathology and applied neurobiology, , Volume: 42, Issue:1, 2016
Prevalence of Submandibular Gland Synucleinopathy in Parkinson's Disease, Dementia with Lewy Bodies and other Lewy Body Disorders.Journal of Parkinson's disease, , Volume: 6, Issue:1, 2016
Dynamic Changes in Striatal mGluR1 But Not mGluR5 during Pathological Progression of Parkinson's Disease in Human Alpha-Synuclein A53T Transgenic Rats: A Multi-PET Imaging Study.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jan-13, Volume: 36, Issue:2, 2016
Differential interaction between iron and mutant alpha-synuclein causes distinctive Parkinsonian phenotypes in Drosophila.Biochimica et biophysica acta, , Volume: 1862, Issue:4, 2016
Variants in the SNCA gene associate with motor progression while variants in the MAPT gene associate with the severity of Parkinson's disease.Parkinsonism & related disorders, , Volume: 24, 2016
Mesenchymal Stem Cells Inhibit Transmission of α-Synuclein by Modulating Clathrin-Mediated Endocytosis in a Parkinsonian Model.Cell reports, , Feb-02, Volume: 14, Issue:4, 2016
Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains.Journal of visualized experiments : JoVE, , Jan-05, Issue:107, 2016
Parkinson disease in 2015: Evolving basic, pathological and clinical concepts in PD.Nature reviews. Neurology, , Volume: 12, Issue:2, 2016
Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson's disease.Molecular neurodegeneration, , Jan-19, Volume: 11, 2016
Synaptic failure and α-synuclein.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Acupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain.Scientific reports, , Jan-21, Volume: 6, 2016
Editorial overview: Neurobiology of disease.Current opinion in neurobiology, , Volume: 36, 2016
Peripheral Synucleinopathy in Early Parkinson's Disease: Submandibular Gland Needle Biopsy Findings.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Stabilization of α-Synuclein Fibril Clusters Prevents Fragmentation and Reduces Seeding Activity and Toxicity.Biochemistry, , Feb-02, Volume: 55, Issue:4, 2016
Gut Feelings About α-Synuclein in Gastrointestinal Biopsies: Biomarker in the Making?Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
The Contursi Family 20 Years Later: Intrafamilial Phenotypic Variability of the SNCA p.A53T Mutation.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites.Nature communications, , Jan-25, Volume: 7, 2016
Lewy- and Alzheimer-type pathologies in midbrain and cerebellum across the Lewy body disorders spectrum.Neuropathology and applied neurobiology, , Volume: 42, Issue:5, 2016
Autophagy and Alpha-Synuclein: Relevance to Parkinson's Disease and Related Synucleopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
The role of biomarkers and imaging in Parkinson's disease.Expert review of neurotherapeutics, , Volume: 16, Issue:2, 2016
A comparative study of the amount of α-synuclein in ischemic stroke and Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 37, Issue:5, 2016
Direct α-synuclein promoter transactivation by the tumor suppressor p53.Molecular neurodegeneration, , Feb-02, Volume: 11, 2016
Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , Feb-16, Volume: 113, Issue:7, 2016
α-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models.Proceedings of the National Academy of Sciences of the United States of America, , Feb-16, Volume: 113, Issue:7, 2016
Structural remodeling during amyloidogenesis of physiological Nα-acetylated α-synuclein.Biochimica et biophysica acta, , Volume: 1864, Issue:5, 2016
The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease.Journal of neurochemistry, , Volume: 137, Issue:3, 2016
Preface.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Humoral cross reactivity between α-synuclein and herpes simplex-1 epitope in Parkinson's disease, a triggering role in the disease?Journal of neuroimmunology, , Feb-15, Volume: 291, 2016
Parkinson's disease: acid-glucocerebrosidase activity and alpha-synuclein clearance.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer's and Parkinson's Disease.International journal of molecular sciences, , Feb-06, Volume: 17, Issue:2, 2016
Age at onset and Parkinson disease phenotype.Neurology, , Apr-12, Volume: 86, Issue:15, 2016
Longitudinal Measurements of Cerebrospinal Fluid Biomarkers in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:6, 2016
Microwave fields have little effect on α-synuclein aggregation in a Caenorhabditis elegans model of Parkinson's disease.Bioelectromagnetics, , Volume: 37, Issue:2, 2016
Imaging synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:6, 2016
Schizophrenia as a prodromal symptom in a patient harboring SNCA duplication.Parkinsonism & related disorders, , Volume: 25, 2016
Alpha synuclein and crystallin expression in human lens in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:4, 2016
Alpha-synuclein gene variants may predict neurostimulation outcome.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:4, 2016
The novel adaptive rotating beam test unmasks sensorimotor impairments in a transgenic mouse model of Parkinson's disease.Behavioural brain research, , May-01, Volume: 304, 2016
FBXO7 mutations in Parkinson's disease and multiple system atrophy.Neurobiology of aging, , Volume: 40, 2016
An A-PLAuse to a new assay that unveils previously undetected alpha-synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:3, 2016
ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons.Stem cell reports, , Mar-08, Volume: 6, Issue:3, 2016
microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-24, Volume: 36, Issue:8, 2016
BPOZ-2 Gene Delivery Ameliorates Alpha-Synucleinopathy in A53T Transgenic Mouse Model of Parkinson's Disease.Scientific reports, , Feb-26, Volume: 6, 2016
Effects of different isoforms of apoE on aggregation of the α-synuclein protein implicated in Parkinson's disease.Neuroscience letters, , Apr-08, Volume: 618, 2016
A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins.ACS combinatorial science, , Mar-14, Volume: 18, Issue:3, 2016
Lysosomal Dysfunction and α-Synuclein Aggregation in Parkinson's Disease: Diagnostic Links.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:6, 2016
ɑ-Synuclein strains and the variable pathologies of synucleinopathies.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Targeting α-synuclein: Therapeutic options.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:6, 2016
X-ray Crystallographic Structure of Oligomers Formed by a Toxic β-Hairpin Derived from α-Synuclein: Trimers and Higher-Order Oligomers.Journal of the American Chemical Society, , Apr-06, Volume: 138, Issue:13, 2016
Excessive Iron and α-Synuclein Oligomer in Brain are Relevant to Pure Apathy in Parkinson Disease.Journal of geriatric psychiatry and neurology, , Volume: 29, Issue:4, 2016
Alpha-Synuclein as a Biomarker for Parkinson's Disease.Brain pathology (Zurich, Switzerland), , Volume: 26, Issue:3, 2016
Synaptotagmin XI in Parkinson's disease: New evidence from an association study in Spain and Mexico.Journal of the neurological sciences, , Mar-15, Volume: 362, 2016
Glycation in Parkinson's disease and Alzheimer's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:6, 2016
Innate immunity regulates α-synuclein clearance.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:5, 2016
Up-regulation of SNCA gene expression: implications to synucleinopathies.Neurogenetics, , Volume: 17, Issue:3, 2016
Impact of the α-Synuclein Initial Ensemble Structure on Fibrillation Pathways and Kinetics.The journal of physical chemistry. B, , Mar-31, Volume: 120, Issue:12, 2016
Copper dyshomoeostasis in Parkinson's disease: implications for pathogenesis and indications for novel therapeutics.Clinical science (London, England : 1979), , Volume: 130, Issue:8, 2016
Pathological and clinical aspects of alpha/beta synuclein in Parkinson's disease and related disorders.Expert review of neurotherapeutics, , Volume: 16, Issue:5, 2016
Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector.Journal of visualized experiments : JoVE, , Feb-28, Issue:108, 2016
Subgroup differences in 'brain-type' transferrin and α-synuclein in Parkinson's disease and multiple system atrophy.Journal of biochemistry, , Volume: 160, Issue:2, 2016
The red-hot debate about transmissible Alzheimer's.Nature, , Mar-17, Volume: 531, Issue:7594, 2016
Functionally different α-synuclein inclusions yield insight into Parkinson's disease pathology.Scientific reports, , Mar-17, Volume: 6, 2016
Ca2+ is a key factor in α-synuclein-induced neurotoxicity.Journal of cell science, , 05-01, Volume: 129, Issue:9, 2016
Hippocampal α-synuclein and interneurons in Parkinson's disease: Data from human and mouse models.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:7, 2016
α-Synuclein in Extracellular Vesicles: Functional Implications and Diagnostic Opportunities.Cellular and molecular neurobiology, , Volume: 36, Issue:3, 2016
Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons.Proceedings of the National Academy of Sciences of the United States of America, , Apr-05, Volume: 113, Issue:14, 2016
α-Mangostin Inhibits α-Synuclein-Induced Microglial Neuroinflammation and Neurotoxicity.Cellular and molecular neurobiology, , Volume: 36, Issue:5, 2016
Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?Journal of Parkinson's disease, , Volume: 6, Issue:1, 2016
Alterations in Activity-Dependent Neuroprotective Protein in Sporadic and Experimental Parkinson's Disease.Journal of Parkinson's disease, , Volume: 6, Issue:1, 2016
Extracellular α-synuclein--a possible initiator of inflammation in Parkinson's disease.Die Pharmazie, , Volume: 71, Issue:2, 2016
Abnormal Salivary Total and Oligomeric Alpha-Synuclein in Parkinson's Disease.PloS one, , Volume: 11, Issue:3, 2016
The novel mechanism of rotenone-induced α-synuclein phosphorylation via reduced protein phosphatase 2A activity.The international journal of biochemistry & cell biology, , Volume: 75, 2016
Pathological α-synuclein in gastrointestinal tissues from prodromal Parkinson disease patients.Annals of neurology, , Volume: 79, Issue:6, 2016
Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein.Nature structural & molecular biology, , Volume: 23, Issue:5, 2016
How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease?Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration.PLoS genetics, , Volume: 12, Issue:3, 2016
The role of alpha-synuclein in the development of the dopaminergic neurons in the substantia nigra and ventral tegmental area.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, , Volume: 466, 2016
Motor and Nonmotor Features of Carriers of the p.A53T Alpha-Synuclein Mutation: A Longitudinal Study.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:8, 2016
High expression of α-synuclein in damaged mitochondria with PLA2G6 dysfunction.Acta neuropathologica communications, , Mar-30, Volume: 4, 2016
Oligomeropathies and pathogenesis of Alzheimer and Parkinson's diseases.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:6, 2016
Assessment of α-synuclein in submandibular glands of patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study.The Lancet. Neurology, , Volume: 15, Issue:7, 2016
Cerebrospinal fluid biomarkers and clinical features in leucine-rich repeat kinase 2 (LRRK2) mutation carriers.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:6, 2016
Evaluation of alpha-synuclein immunohistochemical methods for the detection of Lewy-type synucleinopathy in gastrointestinal biopsies.Acta neuropathologica communications, , Apr-04, Volume: 4, 2016
V63 and N65 of overexpressed α-synuclein are involved in mitochondrial dysfunction.Brain research, , 07-01, Volume: 1642, 2016
Atp13a2 expression in the periaqueductal gray is decreased in the Pink1 -/- rat model of Parkinson disease.Neuroscience letters, , 05-16, Volume: 621, 2016
Brain Atrophy of Secondary REM-Sleep Behavior Disorder in Neurodegenerative Disease.Journal of Alzheimer's disease : JAD, , 04-05, Volume: 52, Issue:3, 2016
Cortical phosphorylated α-Synuclein levels correlate with brain wave spectra in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:7, 2016
The Parkinson Disease gene SNCA: Evolutionary and structural insights with pathological implication.Scientific reports, , Apr-15, Volume: 6, 2016
Parkinson disease: Peripheral α-synuclein deposits - prodromal markers for Parkinson disease?Nature reviews. Neurology, , Volume: 12, Issue:5, 2016
Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Cellular models for Parkinson's disease.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
α-synuclein genetic variability: A biomarker for dementia in Parkinson disease.Annals of neurology, , Volume: 79, Issue:6, 2016
Resequencing analysis of five Mendelian genes and the top genes from genome-wide association studies in Parkinson's Disease.Molecular neurodegeneration, , Apr-19, Volume: 11, 2016
Parkinson's disease: Guilt by genetic association.Nature, , May-05, Volume: 533, Issue:7601, 2016
Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression.Nature, , May-05, Volume: 533, Issue:7601, 2016
Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease.Acta neuropathologica communications, , Apr-22, Volume: 4, 2016
Coordination and redox properties of copper interaction with α-synuclein.Journal of inorganic biochemistry, , Volume: 163, 2016
A First Tetraplex Assay for the Simultaneous Quantification of Total α-Synuclein, Tau, β-Amyloid42 and DJ-1 in Human Cerebrospinal Fluid.PloS one, , Volume: 11, Issue:4, 2016
DNA methylation in Parkinson's disease.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Thiol Oxidation by Diamide Leads to Dopaminergic Degeneration and Parkinsonism Phenotype in Mice: A Model for Parkinson's Disease.Antioxidants & redox signaling, , 08-10, Volume: 25, Issue:5, 2016
shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity.PLoS genetics, , Volume: 12, Issue:4, 2016
Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson's disease.Human molecular genetics, , 07-01, Volume: 25, Issue:13, 2016
Inhibition of Excessive Oxidative Protein Folding Is Protective in MPP(+) Toxicity-Induced Parkinson's Disease Models.Antioxidants & redox signaling, , 09-10, Volume: 25, Issue:8, 2016
Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain.Proceedings of the National Academy of Sciences of the United States of America, , 06-07, Volume: 113, Issue:23, 2016
The Involvement of His50 during Protein Disulfide Isomerase Binding Is Essential for Inhibiting α-Syn Fibril Formation.Biochemistry, , 05-17, Volume: 55, Issue:19, 2016
Early-onset motor impairment and increased accumulation of phosphorylated α-synuclein in the motor cortex of normal aging mice are ameliorated by coenzyme Q.Experimental gerontology, , Volume: 81, 2016
Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 05-04, Volume: 36, Issue:18, 2016
Increased CSF biomarkers of angiogenesis in Parkinson disease.Neurology, , 05-03, Volume: 86, Issue:18, 2016
Geniposide reduces α-synuclein by blocking microRNA-21/lysosome-associated membrane protein 2A interaction in Parkinson disease models.Brain research, , 08-01, Volume: 1644, 2016
Changes in the sympathetic innervation of the gut in rotenone treated mice as possible early biomarker for Parkinson's disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 26, Issue:3, 2016
Derivation, Characterization, and Neural Differentiation of Integration-Free Induced Pluripotent Stem Cell Lines from Parkinson's Disease Patients Carrying SNCA, LRRK2, PARK2, and GBA Mutations.PloS one, , Volume: 11, Issue:5, 2016
What can trigger the onset of Parkinson's disease - A modeling study based on a compartmental model of α-synuclein transport and aggregation in neurons.Mathematical biosciences, , Volume: 278, 2016
α-Synuclein Fibrils Exhibit Gain of Toxic Function, Promoting Tau Aggregation and Inhibiting Microtubule Assembly.The Journal of biological chemistry, , 07-15, Volume: 291, Issue:29, 2016
[SNCA rs356219 AND rs356165 VARIANTS ARE ASSOCIATED WITH PARKINSON'S DISEASE AND INCREASED ALPHA-SYNUCLEIN GENE EXPRESSION IN THE CD45(+)-BLOOD CELLS].Tsitologiia, , Volume: 58, Issue:2, 2016
Subcortical matter in the α-synucleinopathies spectrum: an MRI pilot study.Journal of neurology, , Volume: 263, Issue:8, 2016
Up-regulation of activating transcription factor 4 induces severe loss of dopamine nigral neurons in a rat model of Parkinson's disease.Neuroscience letters, , 08-03, Volume: 627, 2016
A53T in a parkinsonian family: a clinical update of the SNCA phenotypes.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 123, Issue:11, 2016
Vagal neurocircuitry and its influence on gastric motility.Nature reviews. Gastroenterology & hepatology, , Volume: 13, Issue:7, 2016
Engineering therapeutic protein disaggregases.Molecular biology of the cell, , 05-15, Volume: 27, Issue:10, 2016
How strong is the evidence that Parkinson's disease is a prion disorder?Current opinion in neurology, , Volume: 29, Issue:4, 2016
Mitochondrial DNA in CSF distinguishes LRRK2 from idiopathic Parkinson's disease.Neurobiology of disease, , Volume: 94, 2016
The nonmotor features of Parkinson's disease: pathophysiology and management advances.Current opinion in neurology, , Volume: 29, Issue:4, 2016
Increased copper toxicity in Saccharomyces cerevisiae lacking VPS35, a component of the retromer and monogenic Parkinson disease gene in humans.Biochemical and biophysical research communications, , 08-05, Volume: 476, Issue:4, 2016
Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson's Disease Patients.Cell reports, , 06-14, Volume: 15, Issue:11, 2016
Development of an ultra-high sensitive immunoassay with plasma biomarker for differentiating Parkinson disease dementia from Parkinson disease using antibody functionalized magnetic nanoparticles.Journal of nanobiotechnology, , Jun-08, Volume: 14, Issue:1, 2016
α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease.Science translational medicine, , 06-08, Volume: 8, Issue:342, 2016
A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death.Human molecular genetics, , 07-15, Volume: 25, Issue:14, 2016
Diagnostic utility of CSF α-synuclein species in Parkinson's disease: protocol for a systematic review and meta-analysis.BMJ open, , 06-13, Volume: 6, Issue:6, 2016
Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , 06-28, Volume: 113, Issue:26, 2016
Piceatannol and Other Wine Stilbenes: A Pool of Inhibitors against α-Synuclein Aggregation and Cytotoxicity.Nutrients, , Jun-15, Volume: 8, Issue:6, 2016
Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles.PloS one, , Volume: 11, Issue:6, 2016
Similar α-Synuclein staining in the colon mucosa in patients with Parkinson's disease and controls.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:10, 2016
The rs3857059 variant of the SNCA gene is associated with Parkinson's disease in Mexican Mestizos.Arquivos de neuro-psiquiatria, , Volume: 74, Issue:6, 2016
Salivary total α-synuclein, oligomeric α-synuclein and SNCA variants in Parkinson's disease patients.Scientific reports, , 06-23, Volume: 6, 2016
C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson's Disease.PLoS genetics, , Volume: 12, Issue:6, 2016
Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson's disease.Free radical biology & medicine, , Volume: 97, 2016
Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration.The Journal of clinical investigation, , 08-01, Volume: 126, Issue:8, 2016
Epigallocatechin Gallate (EGCG) Inhibits Alpha-Synuclein Aggregation: A Potential Agent for Parkinson's Disease.Neurochemical research, , Volume: 41, Issue:10, 2016
Exploring the Transition of Human α-Synuclein from Native to the Fibrillar State: Insights into the Pathogenesis of Parkinson's Disease.Journal of fluorescence, , Volume: 26, Issue:5, 2016
Is age-related failure of metabolic reprogramming a principal mediator in idiopathic Parkinson's disease? Implications for treatment and inverse cancer risk.Medical hypotheses, , Volume: 93, 2016
MAPT haplotype diversity in multiple system atrophy.Parkinsonism & related disorders, , Volume: 30, 2016
Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease.Human molecular genetics, , 08-15, Volume: 25, Issue:16, 2016
The Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation.The Journal of biological chemistry, , 09-02, Volume: 291, Issue:36, 2016
Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation.The Journal of biological chemistry, , 08-26, Volume: 291, Issue:35, 2016
The diagnostic discrimination of cutaneous α-synuclein deposition in Parkinson disease.Neurology, , Aug-02, Volume: 87, Issue:5, 2016
Bee venom phospholipase A2 ameliorates motor dysfunction and modulates microglia activation in Parkinson's disease alpha-synuclein transgenic mice.Experimental & molecular medicine, , 07-08, Volume: 48, Issue:7, 2016
Longitudinal live imaging of retinal α-synuclein::GFP deposits in a transgenic mouse model of Parkinson's Disease/Dementia with Lewy Bodies.Scientific reports, , 07-08, Volume: 6, 2016
The heterozygous A53T mutation in the alpha-synuclein gene in a Chinese Han patient with Parkinson disease: case report and literature review.Journal of neurology, , Volume: 263, Issue:10, 2016
[Autophagy pathways and key drug targets in Parkinson's disease].Yao xue xue bao = Acta pharmaceutica Sinica, , Volume: 51, Issue:1, 2016
From the Cover: Arsenic Induces Accumulation of α-Synuclein: Implications for Synucleinopathies and Neurodegeneration.Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 153, Issue:2, 2016
The rs3756063 polymorphism is associated with SNCA methylation in the Chinese Han population.Journal of the neurological sciences, , Aug-15, Volume: 367, 2016
White matter hyperintensities, cerebrospinal amyloid-β and dementia in Parkinson's disease.Journal of the neurological sciences, , Aug-15, Volume: 367, 2016
Gut dysfunction in Parkinson's disease.World journal of gastroenterology, , Jul-07, Volume: 22, Issue:25, 2016
Gastrointestinal Dysfunction and Neuropathologic Correlations in Parkinson Disease.Journal of clinical gastroenterology, , Volume: 50, Issue:9, 2016
Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 07-20, Volume: 36, Issue:29, 2016
Mutation analysis of the PARKIN, PINK1, DJ1, and SNCA genes in Turkish early-onset Parkinson's patients and genotype-phenotype correlations.Clinical neurology and neurosurgery, , Volume: 148, 2016
Beta-asarone protects against MPTP-induced Parkinson's disease via regulating long non-coding RNA MALAT1 and inhibiting α-synuclein protein expression.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 83, 2016
[A Therapeutic Target for Inhibition of Neurodegeneration: Autophagy].Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova, , Volume: 66, Issue:5, 2016
From the Cover: Alterations in Optineurin Expression and Localization in Pre-clinical Parkinson's Disease Models.Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 153, Issue:2, 2016
The effect of fluorescent labeling on α-synuclein fibril morphology.Biochimica et biophysica acta, , Volume: 1864, Issue:10, 2016
α-Synuclein: Experimental Pathology.Cold Spring Harbor perspectives in medicine, , Sep-01, Volume: 6, Issue:9, 2016
Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril.Scientific reports, , 08-04, Volume: 6, 2016
Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson's disease.The Journal of experimental medicine, , 08-22, Volume: 213, Issue:9, 2016
Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson's disease.Oncotarget, , Aug-23, Volume: 7, Issue:34, 2016
Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease.PloS one, , Volume: 11, Issue:8, 2016
Copper Binding and Subsequent Aggregation of α-Synuclein Are Modulated by N-Terminal Acetylation and Ablated by the H50Q Missense Mutation.Biochemistry, , 08-30, Volume: 55, Issue:34, 2016
FTY720/Fingolimod Reduces Synucleinopathy and Improves Gut Motility in A53T Mice: CONTRIBUTIONS OF PRO-BRAIN-DERIVED NEUROTROPHIC FACTOR (PRO-BDNF) AND MATURE BDNF.The Journal of biological chemistry, , 09-23, Volume: 291, Issue:39, 2016
SNCA rs356182 variant increases risk of sporadic Parkinson's disease in ethnic Chinese.Journal of the neurological sciences, , Sep-15, Volume: 368, 2016
Self-Assembled Cyclic d,l-α-Peptides as Generic Conformational Inhibitors of the α-Synuclein Aggregation and Toxicity: In Vitro and Mechanistic Studies.Chemistry (Weinheim an der Bergstrasse, Germany), , Sep-26, Volume: 22, Issue:40, 2016
Longitudinal changes in CSF alpha-synuclein species reflect Parkinson's disease progression.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:10, 2016
A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein.Molecular neurodegeneration, , 08-22, Volume: 11, Issue:1, 2016
Caspase-1 clipping causes complications for α-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , Sep-06, Volume: 113, Issue:36, 2016
Cerebrospinal Fluid Biomarkers in Highly Exposed PM2.5 Urbanites: The Risk of Alzheimer's and Parkinson's Diseases in Young Mexico City Residents.Journal of Alzheimer's disease : JAD, , 09-06, Volume: 54, Issue:2, 2016
Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation.Proceedings of the National Academy of Sciences of the United States of America, , 09-13, Volume: 113, Issue:37, 2016
Potential Pathways of Abnormal Tau and α-Synuclein Dissemination in Sporadic Alzheimer's and Parkinson's Diseases.Cold Spring Harbor perspectives in biology, , Nov-01, Volume: 8, Issue:11, 2016
Multicenter Assessment of Immunohistochemical Methods for Pathological Alpha-Synuclein in Sigmoid Colon of Autopsied Parkinson's Disease and Control Subjects.Journal of Parkinson's disease, , 10-19, Volume: 6, Issue:4, 2016
Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation.The Journal of cell biology, , 09-12, Volume: 214, Issue:6, 2016
'Under pressure': is there a link between orthostatic hypotension and cognitive impairment in α-synucleinopathies?Journal of neurology, neurosurgery, and psychiatry, , Volume: 87, Issue:12, 2016
Lysosomal trafficking defects link Parkinson's disease with Gaucher's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:11, 2016
Alpha-Synuclein Proteins Promote Pro-Inflammatory Cascades in Microglia: Stronger Effects of the A53T Mutant.PloS one, , Volume: 11, Issue:9, 2016
Total α-synuclein levels in human blood cells, CSF, and saliva determined by a lipid-ELISA.Analytical and bioanalytical chemistry, , Volume: 408, Issue:27, 2016
α-Synuclein is a Novel Microtubule Dynamase.Scientific reports, , 09-15, Volume: 6, 2016
Interactions Between α-Synuclein and Tau Protein: Implications to Neurodegenerative Disorders.Journal of molecular neuroscience : MN, , Volume: 60, Issue:3, 2016
Acteoside Binds to Caspase-3 and Exerts Neuroprotection in the Rotenone Rat Model of Parkinson's Disease.PloS one, , Volume: 11, Issue:9, 2016
α-Synuclein pre-formed fibrils impair tight junction protein expression without affecting cerebral endothelial cell function.Experimental neurology, , Volume: 285, Issue:Pt A, 2016
Chronic mild stress accelerates the progression of Parkinson's disease in A53T α-synuclein transgenic mice.Experimental neurology, , Volume: 285, Issue:Pt A, 2016
Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation.Stem cell reports, , 10-11, Volume: 7, Issue:4, 2016
Perspective: Finding common ground.Nature, , 09-22, Volume: 537, Issue:7621, 2016
An Overview on the Role of α -Synuclein in Experimental Models of Parkinson's Disease from Pathogenesis to Therapeutics.CNS & neurological disorders drug targets, , Volume: 15, Issue:10, 2016
Novel Dimer Compounds That Bind α-Synuclein Can Rescue Cell Growth in a Yeast Model Overexpressing α-Synuclein. A Possible Prevention Strategy for Parkinson's Disease.ACS chemical neuroscience, , 12-21, Volume: 7, Issue:12, 2016
Investigational α-synuclein aggregation inhibitors: hope for Parkinson's disease.Expert opinion on investigational drugs, , Volume: 25, Issue:11, 2016
A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease.Brain : a journal of neurology, , Volume: 139, Issue:Pt 12, 2016
[Frequency of single nucleotide polymorphisms and alpha-synuclein haplotypes associated with sporadic Parkinson's disease in the Mexican population].Revista de neurologia, , Oct-16, Volume: 63, Issue:8, 2016
Aged Lewis rats exposed to low and moderate doses of rotenone are a good model for studying the process of protein aggregation and its effects upon central nervous system cell physiology.Arquivos de neuro-psiquiatria, , Volume: 74, Issue:9, 2016
Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3.Science (New York, N.Y.), , 09-30, Volume: 353, Issue:6307, 2016
Immune receptor for pathogenic α-synuclein.Science (New York, N.Y.), , 09-30, Volume: 353, Issue:6307, 2016
Parkinson's disease: SNCA-, PARK2-, and LRRK2- targeting microRNAs elevated in cingulate gyrus.Parkinsonism & related disorders, , Volume: 33, 2016
Chemical Compensation of Mitochondrial Phospholipid Depletion in Yeast and Animal Models of Parkinson's Disease.PloS one, , Volume: 11, Issue:10, 2016
Association between common genetic risk variants and depression in Parkinson's disease: A dPD study in Chinese.Parkinsonism & related disorders, , Volume: 33, 2016
Quantitative evaluation of orofacial motor function in mice: The pasta gnawing test, a voluntary and stress-free behavior test.Journal of neuroscience methods, , 12-01, Volume: 274, 2016
Cutaneous malignant melanoma and Parkinson disease: Common pathways?Annals of neurology, , Volume: 80, Issue:6, 2016
CSF Biomarkers and Its Associations with 18F-AV133 Cerebral VMAT2 Binding in Parkinson's Disease-A Preliminary Report.PloS one, , Volume: 11, Issue:10, 2016
Parkinson disease: LAG3 facilitates cell-to-cell spread of α-synuclein pathology.Nature reviews. Neurology, , Volume: 12, Issue:12, 2016
α-Synuclein-Based Animal Models of Parkinson's Disease: Challenges and Opportunities in a New Era.Trends in neurosciences, , Volume: 39, Issue:11, 2016
Autosomal dominant Parkinson's disease: Incidence of mutations in LRRK2, SNCA, VPS35 and GBA genes in Brazil.Neuroscience letters, , Dec-02, Volume: 635, 2016
TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau.eLife, , 10-25, Volume: 5, 2016
Glucocerebrosidase, Parkinson disease, and the "senses and intellect".Annals of neurology, , Volume: 80, Issue:5, 2016
Two hundred steps.Nature, , 10-27, Volume: 538, Issue:7626, 2016
Parkinson's disease: 4 big questions.Nature, , 10-27, Volume: 538, Issue:7626, 2016
Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 11-01, Volume: 113, Issue:44, 2016
Naturally Occurring Autoantibodies against Tau Protein Are Reduced in Parkinson's Disease Dementia.PloS one, , Volume: 11, Issue:11, 2016
Inhibition of Atg6 and Pi3K59F autophagy genes in neurons decreases lifespan and locomotor ability in Drosophila melanogaster.Genetics and molecular research : GMR, , Oct-24, Volume: 15, Issue:4, 2016
Parkinson Disease.Mayo Clinic proceedings, , Volume: 91, Issue:11, 2016
DNA damage preceding dopamine neuron degeneration in A53T human α-synuclein transgenic mice.Biochemical and biophysical research communications, , Dec-02, Volume: 481, Issue:1-2, 2016
Genetics of Parkinson's disease.Molecular and cellular probes, , Volume: 30, Issue:6, 2016
Defects in trafficking bridge Parkinson's disease pathology and genetics.Nature, , 11-10, Volume: 539, Issue:7628, 2016
Contribution of cholesterol and oxysterols to the pathophysiology of Parkinson's disease.Free radical biology & medicine, , Volume: 101, 2016
Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice.Annals of neurology, , Volume: 80, Issue:5, 2016
Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons.Journal of neuroinflammation, , 11-18, Volume: 13, Issue:1, 2016
Development and characterization of polo-like kinase 2 loaded nanoparticles-A novel strategy for (serine-129) phosphorylation of alpha-synuclein.International journal of pharmaceutics, , Nov-30, Volume: 514, Issue:1, 2016
A novel therapeutic approach for synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:12, 2016
Nanomechanical properties of distinct fibrillar polymorphs of the protein α-synuclein.Scientific reports, , 11-30, Volume: 6, 2016
Towards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parkinson's Disease: Optimization of AAV1/2 Delivery Parameters to Drive Sustained Expression of Alpha Synuclein and Dopaminergic Degeneration in Macaque.PloS one, , Volume: 11, Issue:11, 2016
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease.Cell, , Dec-01, Volume: 167, Issue:6, 2016
Inhibition of Prolyl Oligopeptidase Restores Spontaneous Motor Behavior in the α-Synuclein Virus Vector-Based Parkinson's Disease Mouse Model by Decreasing α-Synuclein Oligomeric Species in Mouse Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 12-07, Volume: 36, Issue:49, 2016
Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease.Science translational medicine, , 12-07, Volume: 8, Issue:368, 2016
The involvement of dityrosine crosslinking in α-synuclein assembly and deposition in Lewy Bodies in Parkinson's disease.Scientific reports, , 12-16, Volume: 6, 2016
Site-specific structural dynamics of α-Synuclein revealed by time-resolved fluorescence spectroscopy: a review.Methods and applications in fluorescence, , 10-11, Volume: 4, Issue:4, 2016
[Circadian Regulation and Its Disorders in Parkinson's Disease Patients. Part 2. Experimental Models, Alpha-Synuclein and Melatonin.]Fiziologiia cheloveka, , Volume: 42, Issue:5, 2016
Viral vector-based models of Parkinson's disease.Current topics in behavioral neurosciences, , Volume: 22, 2015
Defective autophagy in Parkinson's disease: lessons from genetics.Molecular neurobiology, , Volume: 51, Issue:1, 2015
The brainstem pathologies of Parkinson's disease and dementia with Lewy bodies.Brain pathology (Zurich, Switzerland), , Volume: 25, Issue:2, 2015
Spreading of α-synuclein in the face of axonal transport deficits in Parkinson's disease: a speculative synthesis.Neurobiology of disease, , Volume: 77, 2015
Genetic analysis of SNCA coding mutation in Chinese Han patients with Parkinson disease.Acta neurologica Belgica, , Volume: 115, Issue:3, 2015
In vivo gastric detection of α-synuclein inclusions in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:4, 2015
α-Synuclein Misfolding Versus Aggregation Relevance to Parkinson's Disease: Critical Assessment and Modeling.Molecular neurobiology, , Volume: 51, Issue:3, 2015
Potential of Cellular and Animal Models Based on a Prion-Like Propagation of α-Synuclein for Assessing Antiparkinson Agents.Molecular neurobiology, , Volume: 52, Issue:1, 2015
Cerebrospinal fluid alpha-synuclein as a biomarker for Parkinson's disease diagnosis: a systematic review and meta-analysis.The International journal of neuroscience, , Volume: 125, Issue:9, 2015
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Lysosomal dysfunction in Parkinson's disease.Brain : a journal of neurology, , Volume: 138, Issue:Pt 4, 2015
Transgenic rodent models to study alpha-synuclein pathogenesis, with a focus on cognitive deficits.Current topics in behavioral neurosciences, , Volume: 22, 2015
Apoptosis signal-regulating kinase 1 modulates the phenotype of α-synuclein transgenic mice.Neurobiology of aging, , Volume: 36, Issue:1, 2015
Alpha-synuclein as a pathological link between chronic traumatic brain injury and Parkinson's disease.Journal of cellular physiology, , Volume: 230, Issue:5, 2015
Parkinson's disease and age: The obvious but largely unexplored link.Experimental gerontology, , Volume: 68, 2015
Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap?Experimental gerontology, , Volume: 68, 2015
LC-MS-based urinary metabolite signatures in idiopathic Parkinson's disease.Journal of proteome research, , Jan-02, Volume: 14, Issue:1, 2015
The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease.Neuroscience, , Aug-27, Volume: 302, 2015
Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression.Human molecular genetics, , Feb-15, Volume: 24, Issue:4, 2015
Rab11 modulates α-synuclein-mediated defects in synaptic transmission and behaviour.Human molecular genetics, , Feb-15, Volume: 24, Issue:4, 2015
Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease.Human molecular genetics, , Mar-01, Volume: 24, Issue:5, 2015
Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization.Annals of neurology, , Volume: 77, Issue:1, 2015
Head injury, α-synuclein genetic variability and Parkinson's disease.European journal of neurology, , Volume: 22, Issue:5, 2015
Cyclosporine A and MnTMPyP Alleviate α-Synuclein Expression and Aggregation in Cypermethrin-Induced Parkinsonism.Molecular neurobiology, , Volume: 52, Issue:3, 2015
Correlates of cerebrospinal fluid levels of oligomeric- and total-α-synuclein in premotor, motor and dementia stages of Parkinson's disease.Journal of neurology, , Volume: 262, Issue:2, 2015
Neural stem cells in Parkinson's disease: a role for neurogenesis defects in onset and progression.Cellular and molecular life sciences : CMLS, , Volume: 72, Issue:4, 2015
Successful GPi stimulation in genetic Parkinson's disease caused by mosaicism of alpha-synuclein gene duplication: first description.Journal of neurology, , Volume: 262, Issue:1, 2015
CSF biomarkers and clinical progression of Parkinson disease.Neurology, , Jan-06, Volume: 84, Issue:1, 2015
α-Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinson's disease.Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 143, Issue:2, 2015
Acceleration of α-synuclein aggregation by exosomes.The Journal of biological chemistry, , Jan-30, Volume: 290, Issue:5, 2015
Structural features of membrane-bound glucocerebrosidase and α-synuclein probed by neutron reflectometry and fluorescence spectroscopy.The Journal of biological chemistry, , Jan-09, Volume: 290, Issue:2, 2015
(Poly)phenols protect from α-synuclein toxicity by reducing oxidative stress and promoting autophagy.Human molecular genetics, , Mar-15, Volume: 24, Issue:6, 2015
Pathogenic mechanisms of neurodegeneration in Parkinson disease.Neurologic clinics, , Volume: 33, Issue:1, 2015
Parkinson's disease as a member of Prion-like disorders.Virus research, , Sep-02, Volume: 207, 2015
Anti-fibrillation potency of caffeic acid against an antidepressant induced fibrillogenesis of human α-synuclein: Implications for Parkinson's disease.Biochimie, , Volume: 108, 2015
Extracellular ATP induces intracellular alpha-synuclein accumulation via P2X1 receptor-mediated lysosomal dysfunction.Neurobiology of aging, , Volume: 36, Issue:2, 2015
The Parkinson's disease-related protein DJ-1 protects dopaminergic neurons in vivo and cultured cells from alpha-synuclein and 6-hydroxydopamine toxicity.Neuro-degenerative diseases, , Volume: 15, Issue:1, 2015
The H50Q mutation induces a 10-fold decrease in the solubility of α-synuclein.The Journal of biological chemistry, , Jan-23, Volume: 290, Issue:4, 2015
Biomarkers of Parkinson's disease: present and future.Metabolism: clinical and experimental, , Volume: 64, Issue:3 Suppl 1, 2015
Graphene oxide interfaces in serum based autoantibody quantification.Analytical chemistry, , Jan-06, Volume: 87, Issue:1, 2015
A novel bio-orthogonal cross-linker for improved protein/protein interaction analysis.Analytical chemistry, , Feb-03, Volume: 87, Issue:3, 2015
Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein.Neuron, , Jan-07, Volume: 85, Issue:1, 2015
Cutaneous autonomic denervation in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 122, Issue:8, 2015
Inhibition of miR-34b and miR-34c enhances α-synuclein expression in Parkinson's disease.FEBS letters, , Jan-30, Volume: 589, Issue:3, 2015
Parkinson's disease correlates with promoter methylation in the α-synuclein gene.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:4, 2015
Early Parkinson's disease symptoms in α-synuclein transgenic monkeys.Human molecular genetics, , Apr-15, Volume: 24, Issue:8, 2015
Prolyl oligopeptidase enhances α-synuclein dimerization via direct protein-protein interaction.The Journal of biological chemistry, , Feb-20, Volume: 290, Issue:8, 2015
Linking the VPS35 and EIF4G1 pathways in Parkinson's disease.Neuron, , Jan-07, Volume: 85, Issue:1, 2015
MS-based methods for biomarkers of Parkinson's disease: what is the future?Bioanalysis, , Volume: 7, Issue:2, 2015
Social Cognition Impairments in Mice Overexpressing Alpha-Synuclein Under the Thy1 Promoter, a Model of Pre-manifest Parkinson's Disease.Journal of Parkinson's disease, , Volume: 5, Issue:3, 2015
Role of α-synuclein in inducing innate and adaptive immunity in Parkinson disease.Journal of Parkinson's disease, , Volume: 5, Issue:1, 2015
Colonic mucosal a-synuclein lacks specificity as a biomarker for Parkinson disease.Neurology, , Feb-10, Volume: 84, Issue:6, 2015
Unraveling the role of hydrogen peroxide in α-synuclein aggregation using an ultrasensitive nanoplasmonic probe.Analytical chemistry, , Feb-03, Volume: 87, Issue:3, 2015
Lysosomal-associated membrane protein 2 isoforms are differentially affected in early Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:12, 2015
Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors.Neurobiology of aging, , Volume: 36, Issue:3, 2015
Dissociation of glucocerebrosidase dimer in solution by its co-factor, saposin C.Biochemical and biophysical research communications, , Feb-20, Volume: 457, Issue:4, 2015
Head injury, potential interaction with genes, and risk for Parkinson's disease.Parkinsonism & related disorders, , Volume: 21, Issue:3, 2015
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.PloS one, , Volume: 10, Issue:1, 2015
A53T human α-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jan-21, Volume: 35, Issue:3, 2015
Intracellular screening of a peptide library to derive a potent peptide inhibitor of α-synuclein aggregation.The Journal of biological chemistry, , Mar-20, Volume: 290, Issue:12, 2015
New roles of glycosaminoglycans in α-synuclein aggregation in a cellular model of Parkinson disease.PloS one, , Volume: 10, Issue:1, 2015
Polygenic determinants of Parkinson's disease in a Chinese population.Neurobiology of aging, , Volume: 36, Issue:4, 2015
Familial Parkinson disease-associated mutations alter the site-specific microenvironment and dynamics of α-synuclein.The Journal of biological chemistry, , Mar-20, Volume: 290, Issue:12, 2015
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X-linked Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:2, 2015
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation.Nature chemical biology, , Volume: 11, Issue:3, 2015
Insights on the interaction of alpha-synuclein and metals in the pathophysiology of Parkinson's disease.Metallomics : integrated biometal science, , Volume: 7, Issue:3, 2015
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Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo.The Journal of biological chemistry, , Apr-10, Volume: 290, Issue:15, 2015
Anti-human α-synuclein N-terminal peptide antibody protects against dopaminergic cell death and ameliorates behavioral deficits in an AAV-α-synuclein rat model of Parkinson's disease.PloS one, , Volume: 10, Issue:2, 2015
Single fibril growth kinetics of α-synuclein.Journal of molecular biology, , Mar-27, Volume: 427, Issue:6 Pt B, 2015
FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease.Neurobiology of aging, , Volume: 36, Issue:3, 2015
Parkinson disease with REM sleep behavior disorder: features, α-synuclein, and inflammation.Neurology, , Mar-03, Volume: 84, Issue:9, 2015
Involvement of mortalin/GRP75/mthsp70 in the mitochondrial impairments induced by A53T mutant α-synuclein.Brain research, , Apr-16, Volume: 1604, 2015
Pathological interface between oligomeric alpha-synuclein and tau in synucleinopathies.Biological psychiatry, , Nov-15, Volume: 78, Issue:10, 2015
The relation between α-synuclein and microglia in Parkinson's disease: Recent developments.Neuroscience, , Aug-27, Volume: 302, 2015
Multiple system atrophy: the application of genetics in understanding etiology.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 25, Issue:1, 2015
The endosomal pathway in Parkinson's disease.Molecular and cellular neurosciences, , Volume: 66, Issue:Pt A, 2015
Flies with Parkinson's disease.Experimental neurology, , Volume: 274, Issue:Pt A, 2015
NADH fluorescence lifetime is an endogenous reporter of α-synuclein aggregation in live cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 29, Issue:6, 2015
Evaluation of an α synuclein sensitized dendritic cell based vaccine in a transgenic mouse model of Parkinson disease.Human vaccines & immunotherapeutics, , Volume: 11, Issue:4, 2015
α-Synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in Parkinson's disease.Neurobiology of disease, , Volume: 76, 2015
Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease.Neurobiology of disease, , Volume: 77, 2015
Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain.Brain : a journal of neurology, , Volume: 138, Issue:Pt 6, 2015
Progressive aggregation of alpha-synuclein and selective degeneration of lewy inclusion-bearing neurons in a mouse model of parkinsonism.Cell reports, , Mar-03, Volume: 10, Issue:8, 2015
Invasive procedures in Parkinson's disease: let's be aware we are dealing with prion-like proteins.Journal of the neurological sciences, , Apr-15, Volume: 351, Issue:1-2, 2015
A newly discovered neurotoxin ADTIQ associated with hyperglycemia and Parkinson's disease.Biochemical and biophysical research communications, , Apr-10, Volume: 459, Issue:3, 2015
Attenuation of neuromotor deficits by natural antioxidants of Decalepis hamiltonii in transgenic Drosophila model of Parkinson's disease.Neuroscience, , May-07, Volume: 293, 2015
The N Terminus of α-Synuclein Forms Cu(II)-Bridged Oligomers.Chemistry (Weinheim an der Bergstrasse, Germany), , May-04, Volume: 21, Issue:19, 2015
Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease.Trends in biochemical sciences, , Volume: 40, Issue:4, 2015
Neuropathologically mixed Alzheimer's and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes.Acta neuropathologica, , Volume: 129, Issue:5, 2015
Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.Experimental & molecular medicine, , Mar-13, Volume: 47, 2015
Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis.Journal of the American Chemical Society, , Apr-22, Volume: 137, Issue:15, 2015
VPS35 and EIF4G1 interactions and novel candidate genes for PD: from genes to pathways and back.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:4, 2015
Structural alterations of the intestinal epithelial barrier in Parkinson's disease.Acta neuropathologica communications, , Mar-10, Volume: 3, 2015
Targeting α-synuclein oligomers by protein-fragment complementation for drug discovery in synucleinopathies.Expert opinion on therapeutic targets, , Volume: 19, Issue:5, 2015
Glucocerebrosidase and Parkinson disease: Recent advances.Molecular and cellular neurosciences, , Volume: 66, Issue:Pt A, 2015
Parkinson disease: α-synuclein mutational screening and new clinical insight into the p.E46K mutation.Parkinsonism & related disorders, , Volume: 21, Issue:6, 2015
The diagnostic value of minor salivary gland biopsy in clinically diagnosed patients with Parkinson's disease: comparison with DAT PET scans.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 36, Issue:9, 2015
Decrease in plasma levels of α-synuclein is evident in patients with Parkinson's disease after elimination of heterophilic antibody interference.PloS one, , Volume: 10, Issue:4, 2015
Use of CSF α-synuclein in the differential diagnosis between Alzheimer's disease and other neurodegenerative disorders.International psychogeriatrics, , Volume: 27, Issue:9, 2015
Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury.Acta neuropathologica communications, , Mar-24, Volume: 3, 2015
Role of the unfolded protein response in the pathogenesis of Parkinson's disease.Acta neurobiologiae experimentalis, , Volume: 75, Issue:1, 2015
Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling.The Journal of biological chemistry, , May-29, Volume: 290, Issue:22, 2015
Increased 14-3-3 phosphorylation observed in Parkinson's disease reduces neuroprotective potential of 14-3-3 proteins.Neurobiology of disease, , Volume: 79, 2015
The loss of glucose-regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein (α-syn) toxicity to rat nigral neurons.Neurobiology of aging, , Volume: 36, Issue:6, 2015
Reactivity of copper-α-synuclein peptide complexes relevant to Parkinson's disease.Metallomics : integrated biometal science, , Volume: 7, Issue:7, 2015
Could α-synuclein amyloid-like aggregates trigger a prionic neuronal invasion?BioMed research international, , Volume: 2015, 2015
The prion hypothesis of Parkinson's disease.Current neurology and neuroscience reports, , Volume: 15, Issue:5, 2015
The Interplay between Alpha-Synuclein Clearance and Spreading.Biomolecules, , Apr-14, Volume: 5, Issue:2, 2015
Neuroprotective effects of the cultivated Chondrus crispus in a C. elegans model of Parkinson's disease.Marine drugs, , Apr-14, Volume: 13, Issue:4, 2015
Selective loss of glucocerebrosidase activity in sporadic Parkinson's disease and dementia with Lewy bodies.Molecular neurodegeneration, , Mar-27, Volume: 10, 2015
Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity.Molecular neurodegeneration, , Mar-11, Volume: 10, 2015
α-Synuclein pathology accumulates in sacral spinal visceral sensory pathways.Annals of neurology, , Volume: 78, Issue:1, 2015
Neuroimaging in Parkinson's disease: a future perspective.Neurodegenerative disease management, , Volume: 5, Issue:2, 2015
Parkinson's disease and alpha-synucleinopathies: from arising pathways to therapeutic challenge.Central nervous system agents in medicinal chemistry, , Volume: 15, Issue:2, 2015
The role of ATP13A2 in Parkinson's disease: Clinical phenotypes and molecular mechanisms.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:6, 2015
Oligomers of Parkinson's Disease-Related α-Synuclein Mutants Have Similar Structures but Distinctive Membrane Permeabilization Properties.Biochemistry, , May-26, Volume: 54, Issue:20, 2015
Posttranslational Modifications and Clearing of α-Synuclein Aggregates in Yeast.Biomolecules, , Apr-23, Volume: 5, Issue:2, 2015
Relating gas phase to solution conformations: Lessons from disordered proteins.Proteomics, , Volume: 15, Issue:16, 2015
Hyposmia correlates with SNCA variant and non-motor symptoms in Chinese patients with Parkinson's disease.Parkinsonism & related disorders, , Volume: 21, Issue:6, 2015
Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology.Neurobiology of disease, , Volume: 79, 2015
A new role for α-synuclein in Parkinson's disease: Alteration of ER-mitochondrial communication.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:8, 2015
Role of α-synuclein in cognitive dysfunction: Studies in Drosophila melanogaster.Molecular medicine reports, , Volume: 12, Issue:2, 2015
SNCA Gene, but Not MAPT, Influences Onset Age of Parkinson's Disease in Chinese and Australians.BioMed research international, , Volume: 2015, 2015
Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease.Journal of neuroinflammation, , May-14, Volume: 12, 2015
α-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons.Journal of cell science, , Jul-01, Volume: 128, Issue:13, 2015
Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders.Science signaling, , May-12, Volume: 8, Issue:376, 2015
Amyloid-β and α-synuclein cerebrospinal fluid biomarkers and cognition in early Parkinson's disease.Parkinsonism & related disorders, , Volume: 21, Issue:7, 2015
Biomarkers in Parkinson disease: It's time to combine.Neurology, , Jun-16, Volume: 84, Issue:24, 2015
CSF proteins and resting-state functional connectivity in Parkinson disease.Neurology, , Jun-16, Volume: 84, Issue:24, 2015
Splicing: is there an alternative contribution to Parkinson's disease?Neurogenetics, , Volume: 16, Issue:4, 2015
P2X7 receptor is critical in α-synuclein--mediated microglial NADPH oxidase activation.Neurobiology of aging, , Volume: 36, Issue:7, 2015
Mechanisms of alpha-synuclein action on neurotransmission: cell-autonomous and non-cell autonomous role.Biomolecules, , May-13, Volume: 5, Issue:2, 2015
Role of α- and β-Synucleins in the Axonal Pathology of Parkinson's Disease and Related Synucleinopathies.Biomolecules, , May-19, Volume: 5, Issue:2, 2015
Detection of α-synuclein oligomers in red blood cells as a potential biomarker of Parkinson's disease.Neuroscience letters, , Jul-10, Volume: 599, 2015
Transcriptional regulation of the α-synuclein gene in human brain tissue.Neuroscience letters, , Jul-10, Volume: 599, 2015
ExPLAining early synucleinopathies.Brain : a journal of neurology, , Volume: 138, Issue:Pt 6, 2015
Phosphorylated α-synuclein in skin nerve fibres differentiates Parkinson's disease from multiple system atrophy.Brain : a journal of neurology, , Volume: 138, Issue:Pt 8, 2015
Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth.Scientific reports, , May-28, Volume: 5, 2015
The association between infectious burden and Parkinson's disease: A case-control study.Parkinsonism & related disorders, , Volume: 21, Issue:8, 2015
Alpha-Synuclein Pathology in Sensory Nerve Terminals of the Upper Aerodigestive Tract of Parkinson's Disease Patients.Dysphagia, , Volume: 30, Issue:4, 2015
Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations.The Lancet. Neurology, , Volume: 14, Issue:8, 2015
α-Synuclein Shows High Affinity Interaction with Voltage-dependent Anion Channel, Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease.The Journal of biological chemistry, , Jul-24, Volume: 290, Issue:30, 2015
Interaction between Neuromelanin and Alpha-Synuclein in Parkinson's Disease.Biomolecules, , Jun-05, Volume: 5, Issue:2, 2015
Head injury, α-synuclein Rep1 and Parkinson's disease: a meta-analytic view of gene-environment interaction.European journal of neurology, , Volume: 22, Issue:7, 2015
Neurodegeneration: Aggregates feel the strain.Nature, , Jun-18, Volume: 522, Issue:7556, 2015
α-Synuclein strains cause distinct synucleinopathies after local and systemic administration.Nature, , Jun-18, Volume: 522, Issue:7556, 2015
Total and Proteinase K-Resistant α-Synuclein Levels in Erythrocytes, Determined by their Ability to Bind Phospholipids, Associate with Parkinson's Disease.Scientific reports, , Jun-11, Volume: 5, 2015
Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation.Nature communications, , Jun-16, Volume: 6, 2015
Early-onset parkinsonism caused by alpha-synuclein gene triplication: Clinical and genetic findings in a novel family.Parkinsonism & related disorders, , Volume: 21, Issue:8, 2015
Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration.The Journal of biological chemistry, , Aug-07, Volume: 290, Issue:32, 2015
Medial temporal regional argyrophilic grain as a possible important factor affecting dementia in Parkinson's disease.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 35, Issue:5, 2015
Post-translational modification of α-synuclein in Parkinson's disease.Brain research, , Dec-02, Volume: 1628, Issue:Pt B, 2015
Alpha-synuclein A53T mutation is not frequent on a sample of Brazilian Parkinson's disease patients.Arquivos de neuro-psiquiatria, , Volume: 73, Issue:6, 2015
Tea Polyphenols in Parkinson's Disease.Advances in experimental medicine and biology, , Volume: 863, 2015
Validation of a quantitative cerebrospinal fluid alpha-synuclein assay in a European-wide interlaboratory study.Neurobiology of aging, , Volume: 36, Issue:9, 2015
Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease.Human molecular genetics, , Oct-15, Volume: 24, Issue:R1, 2015
[Subtypes of mild cognitive impairment in Parkinson's disease and factors predicting its becoming dementia].Revista de neurologia, , Jul-01, Volume: 61, Issue:1, 2015
α-Synuclein and Lewy pathology in Parkinson's disease.Current opinion in neurology, , Volume: 28, Issue:4, 2015
α-Synuclein in Parkinson's disease: getting to the core of the matter.The Lancet. Neurology, , Volume: 14, Issue:8, 2015
The phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's disease.Journal of neurochemistry, , Volume: 135, Issue:1, 2015
Multiple sclerosis and Parkinson's disease: the two faces of neurodegeneration. Report of the first Greek case and review of the literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 36, Issue:12, 2015
Targeting α-synuclein as a therapeutic strategy for Parkinson's disease.Expert opinion on therapeutic targets, , Volume: 19, Issue:10, 2015
Common pathophysiology affecting diabetic retinopathy and Parkinson's disease.Medical hypotheses, , Volume: 85, Issue:4, 2015
Parkinson disease: Disease-linked morphometric variants of α-synuclein.Nature reviews. Neurology, , Volume: 11, Issue:8, 2015
Diffusion Kurtosis Imaging Detects Microstructural Alterations in Brain of α-Synuclein Overexpressing Transgenic Mouse Model of Parkinson's Disease: A Pilot Study.Neurotoxicity research, , Volume: 28, Issue:4, 2015
Alpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons.Cell death & disease, , Jul-09, Volume: 6, 2015
Heme Stabilization of α-Synuclein Oligomers during Amyloid Fibril Formation.Biochemistry, , Aug-04, Volume: 54, Issue:30, 2015
Alpha-synuclein immunoreactivity patterns in the enteric nervous system.Neuroscience letters, , Aug-18, Volume: 602, 2015
Cysteine cathepsins are essential in lysosomal degradation of α-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , Jul-28, Volume: 112, Issue:30, 2015
L-dopa increases α-synuclein DNA methylation in Parkinson's disease patients in vivo and in vitro.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:13, 2015
Q&A with Dr. John Woulfe.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:8, 2015
Distinctive distribution of phospho-alpha-synuclein in dermal nerves in multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:12, 2015
Colonic bacterial composition in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:10, 2015
Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons.Cell death & disease, , Jul-16, Volume: 6, 2015
Is Cell Death Primary or Secondary in the Pathophysiology of Idiopathic Parkinson's Disease?Biomolecules, , Jul-16, Volume: 5, Issue:3, 2015
Computational Analysis and Functional Prediction of Ubiquitin Hypothetical Protein: A Possible Target in Parkinson Disease.Central nervous system agents in medicinal chemistry, , Volume: 16, Issue:1, 2015
Serotonergic dysfunction in the A53T alpha-synuclein mouse model of Parkinson's disease.Journal of neurochemistry, , Volume: 135, Issue:3, 2015
SNCA rs3822086 C>T Polymorphism Increases the Susceptibility to Parkinson's Disease in a Chinese Han Population.Genetic testing and molecular biomarkers, , Volume: 19, Issue:9, 2015
Peripheral synuclein tissue markers: a step closer to Parkinson's disease diagnosis.Brain : a journal of neurology, , Volume: 138, Issue:Pt 8, 2015
Genetic Variants of SNCA Are Associated with Susceptibility to Parkinson's Disease but Not Amyotrophic Lateral Sclerosis or Multiple System Atrophy in a Chinese Population.PloS one, , Volume: 10, Issue:7, 2015
Did α-Synuclein and Glucocerebrosidase Coevolve? Implications for Parkinson's Disease.PloS one, , Volume: 10, Issue:7, 2015
LK6/Mnk2a is a new kinase of alpha synuclein phosphorylation mediating neurodegeneration.Scientific reports, , Jul-29, Volume: 5, 2015
Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease.Brain : a journal of neurology, , Volume: 138, Issue:Pt 9, 2015
Seeing Is Believing: Alpha-Synuclein Oligomers in Parkinson's Disease Brain.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:10, 2015
Appendectomy may delay Parkinson's disease Onset.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:10, 2015
Cholesterol - A putative endogenous contributor towards Parkinson's disease.Neurochemistry international, , Volume: 90, 2015
Evidence for early and progressive ultrasonic vocalization and oromotor deficits in a PINK1 gene knockout rat model of Parkinson's disease.Journal of neuroscience research, , Volume: 93, Issue:11, 2015
NEURODEGENERATION. Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein.Science (New York, N.Y.), , Aug-07, Volume: 349, Issue:6248, 2015
[Effect of curcumin on oligomer formation and mitochondrial ATP-sensitive potassium channels induced by overexpression or mutation of α-synuclein].Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, , Volume: 32, Issue:4, 2015
REM sleep behavior disorder and neuropathology in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:10, 2015
Amyloid fibrils are the molecular trigger of inflammation in Parkinson's disease.The Biochemical journal, , Nov-01, Volume: 471, Issue:3, 2015
Toxic Oligomeric Alpha-Synuclein Variants Present in Human Parkinson's Disease Brains Are Differentially Generated in Mammalian Cell Models.Biomolecules, , Jul-22, Volume: 5, Issue:3, 2015
Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/α-synuclein aggregation.Autophagy, , Volume: 11, Issue:10, 2015
Human Hsp70 Disaggregase Reverses Parkinson's-Linked α-Synuclein Amyloid Fibrils.Molecular cell, , Sep-03, Volume: 59, Issue:5, 2015
Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation.Molecular neurodegeneration, , Aug-27, Volume: 10, 2015
Transcriptional mutagenesis by 8-oxodG in α-synuclein aggregation and the pathogenesis of Parkinson's disease.Experimental & molecular medicine, , Aug-28, Volume: 47, 2015
Generation of SNCA Cell Models Using Zinc Finger Nuclease (ZFN) Technology for Efficient High-Throughput Drug Screening.PloS one, , Volume: 10, Issue:8, 2015
Longitudinal Metabolomics Profiling of Parkinson's Disease-Related α-Synuclein A53T Transgenic Mice.PloS one, , Volume: 10, Issue:8, 2015
VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function.Cell reports, , Sep-08, Volume: 12, Issue:10, 2015
Colonic mucosal α-synuclein lacks specificity as a biomarker for Parkinson disease.Neurology, , Sep-01, Volume: 85, Issue:9, 2015
Role for the microtubule-associated protein tau variant p.A152T in risk of α-synucleinopathies.Neurology, , Nov-10, Volume: 85, Issue:19, 2015
Cuminaldehyde as the Major Component of Cuminum cyminum, a Natural Aldehyde with Inhibitory Effect on Alpha-Synuclein Fibrillation and Cytotoxicity.Journal of food science, , Volume: 80, Issue:10, 2015
Structure of the toxic core of α-synuclein from invisible crystals.Nature, , Sep-24, Volume: 525, Issue:7570, 2015
High Throughput Sequencing Identifies MicroRNAs Mediating α-Synuclein Toxicity by Targeting Neuroactive-Ligand Receptor Interaction Pathway in Early Stage of Drosophila Parkinson's Disease Model.PloS one, , Volume: 10, Issue:9, 2015
GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A.Autophagy, , Volume: 11, Issue:10, 2015
Drugs That Bind to α-Synuclein: Neuroprotective or Neurotoxic?ACS chemical neuroscience, , Dec-16, Volume: 6, Issue:12, 2015
Oligomerization and Membrane-binding Properties of Covalent Adducts Formed by the Interaction of α-Synuclein with the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL).The Journal of biological chemistry, , Nov-13, Volume: 290, Issue:46, 2015
Parkinson's disease, anxious depression and serotonin--zooming in on hippocampal neurogenesis.Journal of neurochemistry, , Volume: 135, Issue:3, 2015
A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy.Molecular neurodegeneration, , Sep-23, Volume: 10, 2015
Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce Its Aggregation in Cells.The Journal of biological chemistry, , Nov-13, Volume: 290, Issue:46, 2015
Immunotherapy in Parkinson's Disease: Micromanaging Alpha-Synuclein Aggregation.Journal of Parkinson's disease, , Volume: 5, Issue:3, 2015
The Synaptic Function of α-Synuclein.Journal of Parkinson's disease, , Volume: 5, Issue:4, 2015
Deconvoluting the complexity of autophagy and Parkinson's disease for potential therapeutic purpose.Oncotarget, , Dec-01, Volume: 6, Issue:38, 2015
DNA methylation levels of α-synuclein intron 1 in the aging brain.Neurobiology of aging, , Volume: 36, Issue:12, 2015
Survival in synucleinopathies: A prospective cohort study.Neurology, , Nov-03, Volume: 85, Issue:18, 2015
Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson's Disease-like Dementia.Cell, , Oct-08, Volume: 163, Issue:2, 2015
Brain-gut-microbiota axis in Parkinson's disease.World journal of gastroenterology, , Oct-07, Volume: 21, Issue:37, 2015
Fractalkine Signaling Regulates the Inflammatory Response in an α-Synuclein Model of Parkinson Disease.PloS one, , Volume: 10, Issue:10, 2015
Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection.Pharmacology & therapeutics, , Volume: 156, 2015
O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease.Nature chemistry, , Volume: 7, Issue:11, 2015
Untangling a role for tau in synucleinopathies.Biological psychiatry, , Nov-15, Volume: 78, Issue:10, 2015
Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways.BMC neuroscience, , Oct-23, Volume: 16, 2015
Gastric motor dysfunctions in Parkinson's disease: Current pre-clinical evidence.Parkinsonism & related disorders, , Volume: 21, Issue:12, 2015
Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease.Biomolecules, , Oct-16, Volume: 5, Issue:4, 2015
Bent out of shape: α-Synuclein misfolding and the convergence of pathogenic pathways in Parkinson's disease.FEBS letters, , Dec-21, Volume: 589, Issue:24 Pt A, 2015
[The Role of Iron and Alpha-synuclein Interacting in Parkinson's Disease].Sheng li ke xue jin zhan [Progress in physiology], , Volume: 46, Issue:3, 2015
Colonic mucosal α-synuclein lacks specificity as a biomarker for Parkinson disease.Neurology, , Sep-01, Volume: 85, Issue:9, 2015
Author response.Neurology, , Sep-01, Volume: 85, Issue:9, 2015
Tianma Gouteng Yin, a Traditional Chinese Medicine decoction, exerts neuroprotective effects in animal and cellular models of Parkinson's disease.Scientific reports, , Nov-18, Volume: 5, 2015
Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants.Scientific reports, , Nov-19, Volume: 5, 2015
Parkinson's Protein α-Synuclein Binds Efficiently and with a Novel Conformation to Two Natural Membrane Mimics.PloS one, , Volume: 10, Issue:11, 2015
Optimizing Western Blots for the Detection of Endogenous α-Synuclein in the Enteric Nervous System.Journal of Parkinson's disease, , Volume: 5, Issue:4, 2015
Associations between Cerebrospinal Fluid Biomarkers and Cognition in Early Untreated Parkinson's Disease.Journal of Parkinson's disease, , Volume: 5, Issue:4, 2015
Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells.Cell death & disease, , Nov-26, Volume: 6, 2015
Synchrotron FTIR micro-spectroscopy for structural analysis of Lewy bodies in the brain of Parkinson's disease patients.Scientific reports, , Dec-01, Volume: 5, 2015
Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson's disease.Acta neuropathologica communications, , Dec-01, Volume: 3, 2015
Loss of parkin promotes lipid rafts-dependent endocytosis through accumulating caveolin-1: implications for Parkinson's disease.Molecular neurodegeneration, , Dec-01, Volume: 10, 2015
α-synuclein interacts with SOD1 and promotes its oligomerization.Molecular neurodegeneration, , Dec-08, Volume: 10, 2015
Cyclosporin promotes neurorestoration and cell replacement therapy in pre-clinical models of Parkinson's disease.Acta neuropathologica communications, , Dec-14, Volume: 3, 2015
The Interaction of Alpha-synuclein with Membranes and its Implication in Parkinson's Disease: A Literature Review.Natural product communications, , Volume: 10, Issue:10, 2015
Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson's disease.Journal of neuroinflammation, , Dec-18, Volume: 12, 2015
[Histopathological and immunohistochemical study of spinal cord tissues in neurodegenerative diseases].Zhonghua bing li xue za zhi = Chinese journal of pathology, , Volume: 44, Issue:8, 2015
Parkinson's disease and prion disease: Straining the comparison.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:13, 2015
Lysosomal alterations in peripheral blood mononuclear cells of Parkinson's disease patients.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:13, 2015
Experimental modelling of -synuclein aggregation and spreading in synucleinopathies.Bulletin de l'Academie nationale de medecine, , Volume: 199, Issue:6, 2015
Immunohistochemical localization of spatacsin in α-synucleinopathies.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 34, Issue:2, 2014
The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson's disease.Biochimica et biophysica acta, , Volume: 1842, Issue:1, 2014
α-Synuclein in the olfactory system in Parkinson's disease: role of neural connections on spreading pathology.Brain structure & function, , Volume: 219, Issue:5, 2014
α-Synuclein in Parkinson's disease: pathogenic function and translation into animal models.Neuro-degenerative diseases, , Volume: 14, Issue:1, 2014
α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease.Free radical biology & medicine, , Volume: 67, 2014
α-Synuclein ubiquitination and novel therapeutic targets for Parkinson's disease.CNS & neurological disorders drug targets, , Volume: 13, Issue:4, 2014
Copper pathology in vulnerable brain regions in Parkinson's disease.Neurobiology of aging, , Volume: 35, Issue:4, 2014
Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice.Human molecular genetics, , Feb-01, Volume: 23, Issue:3, 2014
Defining the native state of α-synuclein.Neuro-degenerative diseases, , Volume: 13, Issue:2-3, 2014
Metabolic abnormalities and hypoleptinemia in α-synuclein A53T mutant mice.Neurobiology of aging, , Volume: 35, Issue:5, 2014
Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson's disease.Acta neuropathologica, , Volume: 127, Issue:2, 2014
Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys.Annals of neurology, , Volume: 75, Issue:3, 2014
Cheek cell-derived α-synuclein and DJ-1 do not differentiate Parkinson's disease from control.Neurobiology of aging, , Volume: 35, Issue:2, 2014
Management of the aging risk factor for Parkinson's disease.Neurobiology of aging, , Volume: 35, Issue:4, 2014
Neuroprotective effects of extract of Acanthopanax senticosus harms on SH-SY5Y cells overexpressing wild-type or A53T mutant α-synuclein.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Apr-15, Volume: 21, Issue:5, 2014
Parkinson's disease in a dish - Using stem cells as a molecular tool.Neuropharmacology, , Volume: 76 Pt A, 2014
Increased amoeboid microglial density in the olfactory bulb of Parkinson's and Alzheimer's patients.Brain pathology (Zurich, Switzerland), , Volume: 24, Issue:2, 2014
The significance of α-synuclein, amyloid-β and tau pathologies in Parkinson's disease progression and related dementia.Neuro-degenerative diseases, , Volume: 13, Issue:2-3, 2014
Genetic causes of Parkinson's disease and their links to autophagy regulation.Parkinsonism & related disorders, , Volume: 20 Suppl 1, 2014
Update on novel familial forms of Parkinson's disease and multiple system atrophy.Parkinsonism & related disorders, , Volume: 20 Suppl 1, 2014
Staged pathology in Parkinson's disease.Parkinsonism & related disorders, , Volume: 20 Suppl 1, 2014
α-Synucleinopathy phenotypes.Parkinsonism & related disorders, , Volume: 20 Suppl 1, 2014
Quantification of α-synuclein in cerebrospinal fluid: how ideal is this biomarker for Parkinson's disease?Parkinsonism & related disorders, , Volume: 20 Suppl 1, 2014
Modeling Lewy pathology propagation in Parkinson's disease.Parkinsonism & related disorders, , Volume: 20 Suppl 1, 2014
A quantitative study of α-synuclein pathology in fifteen cases of dementia associated with Parkinson disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 121, Issue:2, 2014
5-S-cysteinyldopamine neurotoxicity: Influence on the expression of α-synuclein and ERp57 in cellular and animal models of Parkinson's disease.Journal of neuroscience research, , Volume: 92, Issue:3, 2014
Characterization of polyethylene glycol-polyethyleneimine as a vector for alpha-synuclein siRNA delivery to PC12 cells for Parkinson's disease.CNS neuroscience & therapeutics, , Volume: 20, Issue:1, 2014
Heat shock protein 70 reduces α-synuclein-induced predegenerative neuronal dystrophy in the α-synuclein viral gene transfer rat model of Parkinson's disease.CNS neuroscience & therapeutics, , Volume: 20, Issue:1, 2014
Genetic assessment of familial and early-onset Parkinson's disease in a Greek population.European journal of neurology, , Volume: 21, Issue:7, 2014
Clinical and neuroimaging features of patient with early-onset Parkinson's disease with dementia carrying SNCA p.G51D mutation.Parkinsonism & related disorders, , Volume: 20, Issue:2, 2014
Mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice.Neurobiology of aging, , Volume: 35, Issue:5, 2014
Hypomethylation of SNCA in blood of patients with sporadic Parkinson's disease.Journal of the neurological sciences, , Feb-15, Volume: 337, Issue:1-2, 2014
Protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants.Neurobiology of aging, , Volume: 35, Issue:1, 2014
Cerebrospinal fluid α-synuclein levels in Parkinson's disease--changed or unchanged?European journal of neurology, , Volume: 21, Issue:3, 2014
Neurodegenerative disease: Yeast cells reveal new target for Parkinson's disease.Nature reviews. Drug discovery, , Volume: 13, Issue:1, 2014
Electrochemical analysis of the fibrillation of Parkinson's disease α-synuclein.The Analyst, , Feb-21, Volume: 139, Issue:4, 2014
The N-terminus of α-synuclein is essential for both monomeric and oligomeric interactions with membranes.FEBS letters, , Jan-31, Volume: 588, Issue:3, 2014
Alimentary, my dear Watson? The challenges of enteric α-synuclein as a Parkinson's disease biomarker.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:4, 2014
Modeling Parkinson's disease in a dish--a story of yeast and men.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:1, 2014
Squamosamide derivative FLZ protected dopaminergic neuron by activating Akt signaling pathway in 6-OHDA-induced in vivo and in vitro Parkinson's disease models.Brain research, , Feb-14, Volume: 1547, 2014
Neuroinflammation and α-synuclein accumulation in response to glucocerebrosidase deficiency are accompanied by synaptic dysfunction.Molecular genetics and metabolism, , Volume: 111, Issue:2, 2014
Reaping what you sow: Cross-seeding between aggregation-prone proteins in neurodegeneration.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:3, 2014
Methylation of α-synuclein and leucine-rich repeat kinase 2 in leukocyte DNA of Parkinson's disease patients.Parkinsonism & related disorders, , Volume: 20, Issue:3, 2014
c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease.Human molecular genetics, , Jun-01, Volume: 23, Issue:11, 2014
n-butylidenephthalide protects against dopaminergic neuron degeneration and α-synuclein accumulation in Caenorhabditis elegans models of Parkinson's disease.PloS one, , Volume: 9, Issue:1, 2014
Interactions between Tau and α-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease.Human molecular genetics, , Jun-01, Volume: 23, Issue:11, 2014
Predictive association of copper metabolism proteins with Alzheimer's disease and Parkinson's disease: a preliminary perspective.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, , Volume: 27, Issue:1, 2014
Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:8, 2014
Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events.Cell, , Jan-16, Volume: 156, Issue:1-2, 2014
Site-specific fluorescence dynamics of α-synuclein fibrils using time-resolved fluorescence studies: effect of familial Parkinson's disease-associated mutations.Biochemistry, , Feb-11, Volume: 53, Issue:5, 2014
The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans.Metallomics : integrated biometal science, , Volume: 6, Issue:3, 2014
Genetics of Parkinson's disease: alpha-synuclein and other insights from Greece.European journal of neurology, , Volume: 21, Issue:7, 2014
Chronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not α-synuclein-induced neuronal cell loss.PloS one, , Volume: 9, Issue:1, 2014
The pathomechanisms underlying Parkinson's disease.Expert review of neurotherapeutics, , Volume: 14, Issue:2, 2014
Evidence of native α-synuclein conformers in the human brain.The Journal of biological chemistry, , Mar-14, Volume: 289, Issue:11, 2014
Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels.PloS one, , Volume: 9, Issue:1, 2014
Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease.Brain : a journal of neurology, , Volume: 137, Issue:Pt 3, 2014
A30P α-Synuclein interferes with the stable integration of adult-born neurons into the olfactory network.Scientific reports, , Feb-03, Volume: 4, 2014
Immunotherapy targeting α-synuclein, with relevance for future treatment of Parkinson's disease and other Lewy body disorders.Immunotherapy, , Volume: 6, Issue:2, 2014
Intra-axonal protein aggregation in the peripheral nervous system.Journal of the peripheral nervous system : JPNS, , Volume: 19, Issue:1, 2014
Comment: Braak staging in clinical practice?Neurology, , Mar-11, Volume: 82, Issue:10, 2014
Submandibular gland needle biopsy for the diagnosis of Parkinson disease.Neurology, , Mar-11, Volume: 82, Issue:10, 2014
Presynaptic alpha-synuclein aggregation in a mouse model of Parkinson's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-05, Volume: 34, Issue:6, 2014
[Proteomic biomarkers in Parkinson's disease].Revista de neurologia, , Feb-16, Volume: 58, Issue:4, 2014
CSF α-synuclein and UCH-L1 levels in Parkinson's disease and atypical parkinsonian disorders.Parkinsonism & related disorders, , Volume: 20, Issue:4, 2014
Identification of a novel Parkinson's disease locus via stratified genome-wide association study.BMC genomics, , Feb-10, Volume: 15, 2014
A 'bird's eye' view on the current status and potential benefits of blood biomarkers for Parkinson's disease.Biomarkers in medicine, , Volume: 8, Issue:2, 2014
Next-generation active immunization approach for synucleinopathies: implications for Parkinson's disease clinical trials.Acta neuropathologica, , Volume: 127, Issue:6, 2014
The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation.Journal of the American Chemical Society, , Mar-12, Volume: 136, Issue:10, 2014
Glucocerebrosidase is shaking up the synucleinopathies.Brain : a journal of neurology, , Volume: 137, Issue:Pt 5, 2014
Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease.PloS one, , Volume: 9, Issue:2, 2014
Trifluoperazine rescues human dopaminergic cells from wild-type α-synuclein-induced toxicity.Neurobiology of aging, , Volume: 35, Issue:7, 2014
Molecular basis for preventing α-synuclein aggregation by a molecular tweezer.The Journal of biological chemistry, , Apr-11, Volume: 289, Issue:15, 2014
Alpha-synuclein repeat variants and survival in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:8, 2014
Comparable autoantibody serum levels against amyloid- and inflammation-associated proteins in Parkinson's disease patients and controls.PloS one, , Volume: 9, Issue:2, 2014
Zonisamide attenuates α-synuclein neurotoxicity by an aggregation-independent mechanism in a rat model of familial Parkinson's disease.PloS one, , Volume: 9, Issue:2, 2014
Using gastrocnemius sEMG and plasma α-synuclein for the prediction of freezing of gait in Parkinson's disease patients.PloS one, , Volume: 9, Issue:2, 2014
Complex deregulation and expression of cytokines and mediators of the immune response in Parkinson's disease brain is region dependent.Brain pathology (Zurich, Switzerland), , Volume: 24, Issue:6, 2014
Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes.Human molecular genetics, , Jun-01, Volume: 23, Issue:11, 2014
Protein folding and misfolding in the neurodegenerative disorders: a review.Revue neurologique, , Volume: 170, Issue:3, 2014
Do prions cause Parkinson disease?: the evidence accumulates.Annals of neurology, , Volume: 75, Issue:3, 2014
A generic method for design of oligomer-specific antibodies.PloS one, , Volume: 9, Issue:3, 2014
Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice.Human molecular genetics, , Aug-01, Volume: 23, Issue:15, 2014
Sequestration of a β-hairpin for control of α-synuclein aggregation.Angewandte Chemie (International ed. in English), , Apr-14, Volume: 53, Issue:16, 2014
Cerebrospinal fluid α-synuclein predicts cognitive decline in Parkinson disease progression in the DATATOP cohort.The American journal of pathology, , Volume: 184, Issue:4, 2014
Differential aggregation properties of alpha-synuclein isoforms.Neurobiology of aging, , Volume: 35, Issue:8, 2014
Neuroprotective effects of mesenchymal stem cells through autophagy modulation in a parkinsonian model.Neurobiology of aging, , Volume: 35, Issue:8, 2014
RNA metabolism in the pathogenesis of Parkinson׳s disease.Brain research, , Oct-10, Volume: 1584, 2014
Phospholipase D1 regulates autophagic flux and clearance of α-synuclein aggregates.Cell death and differentiation, , Volume: 21, Issue:7, 2014
Skin nerve α-synuclein deposits: a biomarker for idiopathic Parkinson disease.Neurology, , Apr-15, Volume: 82, Issue:15, 2014
Does α-synuclein have a dual and opposing effect in preclinical vs. clinical Parkinson's disease?Parkinsonism & related disorders, , Volume: 20, Issue:6, 2014
Direct visualization of CHIP-mediated degradation of alpha-synuclein in vivo: implications for PD therapeutics.PloS one, , Volume: 9, Issue:3, 2014
Development of targeted therapies for Parkinson's disease and related synucleinopathies.Journal of lipid research, , Volume: 55, Issue:10, 2014
Effect of epicatechin gallate dietary supplementation on transgenic Drosophila model of Parkinson's disease.Journal of dietary supplements, , Volume: 11, Issue:2, 2014
Vaccination strategies for Parkinson disease: induction of a swift attack or raising tolerance?Human vaccines & immunotherapeutics, , Volume: 10, Issue:4, 2014
Association of glycogen synthase kinase-3β with Parkinson's disease (review).Molecular medicine reports, , Volume: 9, Issue:6, 2014
Alpha-synuclein in peripheral tissues and body fluids as a biomarker for Parkinson's disease - a systematic review.Acta neurologica Scandinavica, , Volume: 130, Issue:2, 2014
[Alpha-synuclein in Parkinson's disease].Przeglad lekarski, , Volume: 71, Issue:1, 2014
Pyrosequencing analysis of SNCA methylation levels in leukocytes from Parkinson's disease patients.Neuroscience letters, , May-21, Volume: 569, 2014
Site-specific copper-catalyzed oxidation of α-synuclein: tightening the link between metal binding and protein oxidative damage in Parkinson's disease.Inorganic chemistry, , May-05, Volume: 53, Issue:9, 2014
Multiple system atrophy: a prototypical synucleinopathy for disease-modifying therapeutic strategies.Neurobiology of disease, , Volume: 67, 2014
Roche bets on alpha-synuclein for Parkinson's.Nature biotechnology, , Volume: 32, Issue:3, 2014
The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells.Human molecular genetics, , Sep-01, Volume: 23, Issue:17, 2014
MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration.Nature communications, , Apr-16, Volume: 5, 2014
A revised picture of the Cu(II)-α-synuclein complex: the role of N-terminal acetylation.Biochemistry, , May-06, Volume: 53, Issue:17, 2014
Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson's disease.Neurobiology of aging, , Volume: 35, Issue:10, 2014
Residue histidine 50 plays a key role in protecting α-synuclein from aggregation at physiological pH.The Journal of biological chemistry, , May-30, Volume: 289, Issue:22, 2014
Novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology.Neurobiology of aging, , Volume: 35, Issue:9, 2014
Analysis of Parkinson's disease brain-derived DNA for alpha-synuclein coding somatic mutations.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:8, 2014
Genetic variants and animal models in SNCA and Parkinson disease.Ageing research reviews, , Volume: 15, 2014
Magic shotgun for Parkinson's disease?Brain : a journal of neurology, , Volume: 137, Issue:Pt 5, 2014
Vocalization deficits in mice over-expressing alpha-synuclein, a model of pre-manifest Parkinson's disease.Behavioral neuroscience, , Volume: 128, Issue:2, 2014
Calcium signaling in Parkinson's disease.Cell and tissue research, , Volume: 357, Issue:2, 2014
Phosphorylated α-synuclein-immunoreactive retinal neuronal elements in Parkinson's disease subjects.Neuroscience letters, , Jun-13, Volume: 571, 2014
Cutaneous neuropathy in Parkinson's disease: a window into brain pathology.Acta neuropathologica, , Volume: 128, Issue:1, 2014
[Alpha-Synuclein in blood and cerebrospinal fluid of patients with alpha-synucleinopathy].Rinsho byori. The Japanese journal of clinical pathology, , Volume: 62, Issue:3, 2014
Self-assembly of protein fibrils into suprafibrillar aggregates: bridging the nano- and mesoscale.ACS nano, , Jun-24, Volume: 8, Issue:6, 2014
Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's disease.PLoS genetics, , Volume: 10, Issue:5, 2014
α-synuclein in the inner retina in parkinson disease.Annals of neurology, , Volume: 75, Issue:6, 2014
Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation.Proceedings of the National Academy of Sciences of the United States of America, , May-27, Volume: 111, Issue:21, 2014
Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental Parkinson's disease.Neurobiology of disease, , Volume: 69, 2014
Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.The Journal of biological chemistry, , Jun-27, Volume: 289, Issue:26, 2014
Overexpression of human E46K mutant α-synuclein impairs macroautophagy via inactivation of JNK1-Bcl-2 pathway.Molecular neurobiology, , Volume: 50, Issue:2, 2014
Monoamine oxidase and α-synuclein as targets in Parkinson's disease therapy.Expert review of neurotherapeutics, , Volume: 14, Issue:6, 2014
Modulatory effects of sodium salicylate on the factors affecting protein aggregation during rotenone induced Parkinson's disease pathology.Neurochemistry international, , Volume: 75, 2014
Differential protein profile of PC12 cells exposed to proteasomal inhibitor lactacystin.Neuroscience letters, , Jul-11, Volume: 575, 2014
Accurate prediction of a minimal region around a genetic association signal that contains the causal variant.European journal of human genetics : EJHG, , Volume: 22, Issue:2, 2014
Mouse models for studying the formation and propagation of prions.The Journal of biological chemistry, , Jul-18, Volume: 289, Issue:29, 2014
Guanidine hydrochloride denaturation of dopamine-induced α-synuclein oligomers: a small-angle X-ray scattering study.Proteins, , Volume: 82, Issue:1, 2014
Prions: generation and spread versus neurotoxicity.The Journal of biological chemistry, , Jul-18, Volume: 289, Issue:29, 2014
The PD-associated alpha-synuclein promoter Rep1 allele 2 shows diminished frequency in restless legs syndrome.Neurogenetics, , Volume: 15, Issue:3, 2014
Beta-amyloid, phospho-tau and alpha-synuclein deposits similar to those in the brain are not identified in the eyes of Alzheimer's and Parkinson's disease patients.Brain pathology (Zurich, Switzerland), , Volume: 24, Issue:1, 2014
Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation.The Journal of clinical investigation, , Volume: 124, Issue:7, 2014
Histone deacetylase 6 regulates cytotoxic α-synuclein accumulation through induction of the heat shock response.Neurobiology of aging, , Volume: 35, Issue:10, 2014
The prion hypothesis of Parkinson's disease: this hot topic just got hotter.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:8, 2014
Sleep dysfunction and EEG alterations in mice overexpressing alpha-synuclein.Journal of Parkinson's disease, , Volume: 4, Issue:3, 2014
Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread.Neurobiology of disease, , Volume: 69, 2014
Olfactory deficits in an alpha-synuclein fly model of Parkinson's disease.PloS one, , Volume: 9, Issue:5, 2014
The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models.Cell metabolism, , Jul-01, Volume: 20, Issue:1, 2014
Multiple system atrophy as emerging template for accelerated drug discovery in α-synucleinopathies.Parkinsonism & related disorders, , Volume: 20, Issue:8, 2014
Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:8, 2014
Lysine residues at the first and second KTKEGV repeats mediate α-Synuclein binding to membrane phospholipids.Neurobiology of disease, , Volume: 70, 2014
LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis.Experimental neurology, , Volume: 261, 2014
Glucocerebrosidase deficits in sporadic Parkinson disease.Autophagy, , Volume: 10, Issue:7, 2014
Reply to: Gray et al.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:9, 2014
Reply to: alimentary, my dear Watson? The challenges of enteric α-synuclein as a Parkinson's disease biomarker.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:9, 2014
Microarray-based analyses of monocytes from Chinese Uygur patients with Parkinson's disease and cognitive impairment.Chinese medical journal, , Volume: 127, Issue:12, 2014
Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration.Cell reports, , Jun-26, Volume: 7, Issue:6, 2014
The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity.The Journal of biological chemistry, , Aug-08, Volume: 289, Issue:32, 2014
Catecholamine autotoxicity. Implications for pharmacology and therapeutics of Parkinson disease and related disorders.Pharmacology & therapeutics, , Volume: 144, Issue:3, 2014
Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies.Human molecular genetics, , Dec-01, Volume: 23, Issue:23, 2014
[The role of parkin in Parkinson's disease].Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, , Volume: 16, Issue:2, 2014
[The role of alpha-synuclein in Parkinson's disease].Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, , Volume: 16, Issue:2, 2014
Divergent effects of the H50Q and G51D SNCA mutations on the aggregation of α-synuclein.Journal of neurochemistry, , Volume: 131, Issue:6, 2014
Cell-based assays for Parkinson's disease using differentiated human LUHMES cells.Acta pharmacologica Sinica, , Volume: 35, Issue:7, 2014
Diet-induced obesity accelerates the onset of terminal phenotypes in α-synuclein transgenic mice.Journal of neurochemistry, , Volume: 131, Issue:6, 2014
Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:10, 2014
Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson's disease.Acta neuropathologica, , Volume: 128, Issue:5, 2014
Reduced α-synuclein levels in cerebrospinal fluid in Parkinson's disease are unrelated to clinical and imaging measures of disease severity.European journal of neurology, , Volume: 21, Issue:3, 2014
Parkinson disease: A monoclonal antibody targeting misfolded α-synuclein has therapeutic potential in Parkinson disease.Nature reviews. Neurology, , Volume: 10, Issue:8, 2014
Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson disease-associated α-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , Jul-29, Volume: 111, Issue:30, 2014
Tetranectin knockout mice develop features of Parkinson disease.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , Volume: 34, Issue:2, 2014
Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice.Neurobiology of aging, , Volume: 35, Issue:11, 2014
A GCase chaperone improves motor function in a mouse model of synucleinopathy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 11, Issue:4, 2014
Analysis of dopaminergic neuronal dysfunction in genetic and toxin-induced models of Parkinson's disease in Drosophila.Journal of neurochemistry, , Volume: 131, Issue:3, 2014
Peripheral alpha-synuclein and Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:8, 2014
A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons.Human molecular genetics, , Dec-15, Volume: 23, Issue:24, 2014
Quantitative measurement of intact alpha-synuclein proteoforms from post-mortem control and Parkinson's disease brain tissue by intact protein mass spectrometry.Scientific reports, , Jul-23, Volume: 4, 2014
miR-16-1 promotes the aberrant α-synuclein accumulation in parkinson disease via targeting heat shock protein 70.TheScientificWorldJournal, , Volume: 2014, 2014
DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease.Cell death & disease, , Jul-24, Volume: 5, 2014
Is there a risk of prion-like disease transmission by Alzheimer- or Parkinson-associated protein particles?Acta neuropathologica, , Volume: 128, Issue:4, 2014
The use of nanopore analysis for discovering drugs which bind to α-synuclein for treatment of Parkinson's disease.European journal of medicinal chemistry, , Dec-17, Volume: 88, 2014
Molecular imaging insights into neurodegeneration: focus on α-synuclein radiotracers.Journal of nuclear medicine : official publication, Society of Nuclear Medicine, , Volume: 55, Issue:9, 2014
Late stages of hematopoiesis and B cell lymphopoiesis are regulated by α-synuclein, a key player in Parkinson's disease.Immunobiology, , Volume: 219, Issue:11, 2014
Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson's disease patients.Acta neuropathologica communications, , Aug-07, Volume: 2, 2014
The paths to neurodegeneration in genetic Parkinson's disease.CNS & neurological disorders drug targets, , Volume: 13, Issue:9, 2014
VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease.Neurobiology of disease, , Volume: 71, 2014
Adult hippocampal neurogenesis in Parkinson's disease: impact on neuronal survival and plasticity.Neural plasticity, , Volume: 2014, 2014
α-Synuclein rs356219 polymorphisms in patients with Gaucher disease and Parkinson disease.Neuroscience letters, , Sep-19, Volume: 580, 2014
Walking deficits and centrophobism in an α-synuclein fly model of Parkinson's disease.Genes, brain, and behavior, , Volume: 13, Issue:8, 2014
Calcineurin determines toxic versus beneficial responses to α-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , Aug-26, Volume: 111, Issue:34, 2014
Pharmacological chaperones in the age of proteomic pathology.Proceedings of the National Academy of Sciences of the United States of America, , Aug-26, Volume: 111, Issue:34, 2014
GRP78 clustering at the cell surface of neurons transduces the action of exogenous alpha-synuclein.Cell death and differentiation, , Volume: 21, Issue:12, 2014
SNCA variants rs2736990 and rs356220 as risk factors for Parkinson's disease but not for amyotrophic lateral sclerosis and multiple system atrophy in a Chinese population.Neurobiology of aging, , Volume: 35, Issue:12, 2014
A new Drosophila model to study the interaction between genetic and environmental factors in Parkinson's disease.Brain research, , Oct-02, Volume: 1583, 2014
Is elevated beta-hexosaminidase activity a potential biomarker for Parkinson's disease?Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:10, 2014
Role of α-synuclein in neurodegeneration: implications for the pathogenesis of Parkinson's disease.Essays in biochemistry, , Volume: 56, 2014
Oligomers of α-synuclein: picking the culprit in the line-up.Essays in biochemistry, , Volume: 56, 2014
Lardy brains make Parkinson's disease mice worse.Journal of neurochemistry, , Volume: 131, Issue:6, 2014
Structural insights into amyloid oligomers of the Parkinson disease-related protein α-synuclein.The Journal of biological chemistry, , Sep-26, Volume: 289, Issue:39, 2014
Glucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein.Nature communications, , Aug-26, Volume: 5, 2014
Effect of endogenous Hsp104 chaperone in yeast models of sporadic and familial Parkinson's disease.The international journal of biochemistry & cell biology, , Volume: 55, 2014
Using viral-mediated gene delivery to model Parkinson's disease: do nonhuman primate investigations expand our understanding?Experimental neurology, , Volume: 256, 2014
Systems-based analyses of brain regions functionally impacted in Parkinson's disease reveals underlying causal mechanisms.PloS one, , Volume: 9, Issue:8, 2014
Effects of the adenosine A2A receptor antagonist on cognitive dysfunction in Parkinson's disease.International review of neurobiology, , Volume: 119, 2014
APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease.JAMA neurology, , Volume: 71, Issue:11, 2014
Hippocampal proliferation is increased in presymptomatic Parkinson's disease and due to microglia.Neural plasticity, , Volume: 2014, 2014
Phosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson disease.Proceedings of the National Academy of Sciences of the United States of America, , Sep-23, Volume: 111, Issue:38, 2014
[Pathogenetic mechanisms of dementia in the older patients with Parkinson's diseases].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, , Volume: 114, Issue:7, 2014
High stability and cooperative unfolding of α-synuclein oligomers.Biochemistry, , Oct-07, Volume: 53, Issue:39, 2014
Ignored avenues in alpha-synuclein associated proteopathy.CNS & neurological disorders drug targets, , Volume: 13, Issue:7, 2014
Reduced alpha-synuclein in cerebrospinal fluid in synucleinopathies: evidence from a meta-analysis.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:13, 2014
The newly discovered Parkinson's disease associated Finnish mutation (A53E) attenuates α-synuclein aggregation and membrane binding.Biochemistry, , Oct-21, Volume: 53, Issue:41, 2014
Alpha synuclein is transported into and out of the brain by the blood-brain barrier.Peptides, , Volume: 62, 2014
Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.Acta neuropathologica, , Volume: 128, Issue:6, 2014
Subthalamic deep brain stimulation for a Parkinson's disease patient with duplication of SNCA.Neuromodulation : journal of the International Neuromodulation Society, , Volume: 17, Issue:1, 2014
Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes.Molecular biology of the cell, , Dec-15, Volume: 25, Issue:25, 2014
The key role of sphingosine kinases in the molecular mechanism of neuronal cell survival and death in an experimental model of Parkinson's disease.Folia neuropathologica, , Volume: 52, Issue:3, 2014
α-Synuclein-induced mitochondrial dysfunction in isolated preparation and intact cells: implications in the pathogenesis of Parkinson's disease.Journal of neurochemistry, , Volume: 131, Issue:6, 2014
Skin nerve α-synuclein deposits: a biomarker for idiopathic Parkinson disease.Neurology, , Oct-21, Volume: 83, Issue:17, 2014
Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation.Brain : a journal of neurology, , Volume: 137, Issue:Pt 12, 2014
In vivo markers of Parkinson's disease and dementia with Lewy bodies: current value of the 5G4 α-synuclein antibody.Acta neuropathologica, , Volume: 128, Issue:6, 2014
Early and persistent expression of phosphorylated α-synuclein in the enteric nervous system of A53T mutant human α-synuclein transgenic mice.Journal of neuropathology and experimental neurology, , Volume: 73, Issue:12, 2014
A relationship between the transient structure in the monomeric state and the aggregation propensities of α-synuclein and β-synuclein.Biochemistry, , Nov-25, Volume: 53, Issue:46, 2014
Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication.PloS one, , Volume: 9, Issue:11, 2014
Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.PLoS genetics, , Volume: 10, Issue:11, 2014
Isolating potentiated Hsp104 variants using yeast proteinopathy models.Journal of visualized experiments : JoVE, , Nov-11, Issue:93, 2014
Mutations in RAB39B cause X-linked intellectual disability and early-onset Parkinson disease with α-synuclein pathology.American journal of human genetics, , Dec-04, Volume: 95, Issue:6, 2014
Epigenetic upregulation of alpha-synuclein in the rats exposed to methamphetamine.European journal of pharmacology, , Dec-15, Volume: 745, 2014
α-Synuclein amino terminus regulates mitochondrial membrane permeability.Brain research, , Dec-03, Volume: 1591, 2014
Neurogranin binds α-synuclein in the human superior temporal cortex and interaction is decreased in Parkinson's disease.Brain research, , Dec-03, Volume: 1591, 2014
iPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson's disease.Cell reports, , Nov-20, Volume: 9, Issue:4, 2014
Ida-1, the Caenorhabditis elegans orthologue of mammalian diabetes autoantigen IA-2, potentially acts as a common modulator between Parkinson's disease and Diabetes: role of Daf-2/Daf-16 insulin like signalling pathway.PloS one, , Volume: 9, Issue:12, 2014
Naturally occurring alpha-synuclein autoantibodies in Parkinson's disease: sources of (error) variance in biomarker assays.PloS one, , Volume: 9, Issue:12, 2014
Increased DJ-1 in urine exosome of Korean males with Parkinson's disease.BioMed research international, , Volume: 2014, 2014
Spermidine protects against α-synuclein neurotoxicity.Cell cycle (Georgetown, Tex.), , Volume: 13, Issue:24, 2014
Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment.Autophagy, , Volume: 10, Issue:12, 2014
Differential Co-Expression between α-Synuclein and IFN-γ Signaling Genes across Development and in Parkinson's Disease.PloS one, , Volume: 9, Issue:12, 2014
Models of α-synuclein aggregation in Parkinson's disease.Acta neuropathologica communications, , Dec-13, Volume: 2, 2014
Author response.Neurology, , Oct-21, Volume: 83, Issue:17, 2014
Toll-like receptor expression in the blood and brain of patients and a mouse model of Parkinson's disease.The international journal of neuropsychopharmacology, , Dec-07, Volume: 18, Issue:6, 2014
Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation.Nature communications, , Dec-19, Volume: 5, 2014
Inflammation and α-synuclein's prion-like behavior in Parkinson's disease--is there a link?Molecular neurobiology, , Volume: 47, Issue:2, 2013
Impairment of the septal cholinergic neurons in MPTP-treated A30P α-synuclein mice.Neurobiology of aging, , Volume: 34, Issue:2, 2013
The Lewy body in Parkinson's disease and related neurodegenerative disorders.Molecular neurobiology, , Volume: 47, Issue:2, 2013
Neuropathologic analysis of Lewy-related α-synucleinopathy in olfactory mucosa.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 33, Issue:1, 2013
Animal models of Parkinson's disease: limits and relevance to neuroprotection studies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:1, 2013
Adult neurogenesis in Parkinson's disease.Cellular and molecular life sciences : CMLS, , Volume: 70, Issue:3, 2013
Neuronal vulnerability, pathogenesis, and Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:1, 2013
Selective expression of α-synuclein-immunoreactivity in vesicular acetylcholine transporter-immunoreactive axons in the guinea pig rectum and human colon.The Journal of comparative neurology, , Feb-15, Volume: 521, Issue:3, 2013
The potential prognostic role of cardiovascular autonomic failure in α-synucleinopathies.European journal of neurology, , Volume: 20, Issue:2, 2013
Dietary energy intake modifies brainstem autonomic dysfunction caused by mutant α-synuclein.Neurobiology of aging, , Volume: 34, Issue:3, 2013
Recent advances in α-synuclein functions, advanced glycation, and toxicity: implications for Parkinson's disease.Molecular neurobiology, , Volume: 47, Issue:2, 2013
α-Synuclein and neuronal cell death.Molecular neurobiology, , Volume: 47, Issue:2, 2013
α-Synuclein and protein degradation systems: a reciprocal relationship.Molecular neurobiology, , Volume: 47, Issue:2, 2013
Identification and quantification of oligodendrocyte precursor cells in multiple system atrophy, progressive supranuclear palsy and Parkinson's disease.Brain pathology (Zurich, Switzerland), , Volume: 23, Issue:3, 2013
Personalized medicine strategies for managing patients with parkinsonism and cognitive deficits.Metabolism: clinical and experimental, , Volume: 62 Suppl 1, 2013
Cardiac sympathetic denervation in symptomatic and asymptomatic carriers of the E46K mutation in the α synuclein gene.Parkinsonism & related disorders, , Volume: 19, Issue:1, 2013
Delay discounting of reward and caudate nucleus volume in individuals with α-synuclein gene duplication before and after the development of Parkinson's disease.Neuro-degenerative diseases, , Volume: 11, Issue:2, 2013
Microglial activation and antioxidant responses induced by the Parkinson's disease protein α-synuclein.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 8, Issue:1, 2013
Dysfunction of the locus coeruleus-norepinephrine system and related circuitry in Parkinson's disease-related dementia.Journal of neurology, neurosurgery, and psychiatry, , Volume: 84, Issue:7, 2013
Total CSF α-synuclein is lower in de novo Parkinson patients than in healthy subjects.Neuroscience letters, , Jan-04, Volume: 532, 2013
The Ca2+/Mn2+ ion-pump PMR1 links elevation of cytosolic Ca(2+) levels to α-synuclein toxicity in Parkinson's disease models.Cell death and differentiation, , Volume: 20, Issue:3, 2013
Comparison of the structural characteristics of Cu(2+)-bound and unbound α-syn12 peptide obtained in simulations using different force fields.Journal of molecular modeling, , Volume: 19, Issue:3, 2013
The central theme of Parkinson's disease: α-synuclein.Molecular neurobiology, , Volume: 47, Issue:2, 2013
Genetic variants of SNCA and LRRK2 genes are associated with sporadic PD susceptibility: a replication study in a Taiwanese cohort.Parkinsonism & related disorders, , Volume: 19, Issue:2, 2013
LRRK2 interactions with α-synuclein in Parkinson's disease brains and in cell models.Journal of molecular medicine (Berlin, Germany), , Volume: 91, Issue:4, 2013
100 years of Lewy pathology.Nature reviews. Neurology, , Volume: 9, Issue:1, 2013
Monomeric synucleins generate membrane curvature.The Journal of biological chemistry, , Jan-18, Volume: 288, Issue:3, 2013
Changes in properties of serine 129 phosphorylated α-synuclein with progression of Lewy-type histopathology in human brains.Experimental neurology, , Volume: 240, 2013
α-Synuclein oligomers and clinical implications for Parkinson disease.Annals of neurology, , Volume: 73, Issue:2, 2013
Coordination of copper to the membrane-bound form of α-synuclein.Biochemistry, , Jan-08, Volume: 52, Issue:1, 2013
Naturally occurring α-synuclein autoantibody levels are lower in patients with Parkinson disease.Neurology, , Jan-08, Volume: 80, Issue:2, 2013
Commentary: Progressive inflammation as a contributing factor to early development of Parkinson's disease.Experimental neurology, , Volume: 241, 2013
In vivo neurochemical imaging of olfactory dysfunction in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 120, Issue:4, 2013
Activity-dependent secretion of alpha-synuclein by enteric neurons.Journal of neurochemistry, , Volume: 125, Issue:4, 2013
A conformation-switching fluorescent protein probe for detection of alpha synuclein oligomers.Chemical communications (Cambridge, England), , Nov-25, Volume: 49, Issue:91, 2013
Is α-synuclein rising to the surface as a diagnostic biomarker for Parkinson disease?Neurology, , Oct-29, Volume: 81, Issue:18, 2013
α-Synuclein in cutaneous autonomic nerves.Neurology, , Oct-29, Volume: 81, Issue:18, 2013
The behavioural and neuropathological impact of intranigral AAV-α-synuclein is exacerbated by systemic infusion of the Parkinson's disease-associated pesticide, rotenone, in rats.Behavioural brain research, , Apr-15, Volume: 243, 2013
Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease.The EMBO journal, , Nov-27, Volume: 32, Issue:23, 2013
In-silico analysis for RNA-interference mechanism of α-synuclein to treat Parkinson's disease.International journal of bioinformatics research and applications, , Volume: 9, Issue:6, 2013
Hypercoagulability, parkinsonism, and Gaucher disease.Seminars in thrombosis and hemostasis, , Volume: 39, Issue:8, 2013
Low CSF levels of both α-synuclein and the α-synuclein cleaving enzyme neurosin in patients with synucleinopathy.PloS one, , Volume: 8, Issue:1, 2013
The role of Ser129 phosphorylation of α-synuclein in neurodegeneration of Parkinson's disease: a review of in vivo models.Reviews in the neurosciences, , Volume: 24, Issue:2, 2013
Breaking the limits of artificial ubiquitination.Proceedings of the National Academy of Sciences of the United States of America, , Oct-29, Volume: 110, Issue:44, 2013
Ankyrin repeat and BTB/POZ domain containing protein-2 inhibits the aggregation of alpha-synuclein: implications for Parkinson's disease.FEBS letters, , Nov-01, Volume: 587, Issue:21, 2013
LAMP2A as a therapeutic target in Parkinson disease.Autophagy, , Volume: 9, Issue:12, 2013
Identification of the sites of tau hyperphosphorylation and activation of tau kinases in synucleinopathies and Alzheimer's diseases.PloS one, , Volume: 8, Issue:9, 2013
Curcumin ameliorates the neurodegenerative pathology in A53T α-synuclein cell model of Parkinson's disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 8, Issue:1, 2013
Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.Science (New York, N.Y.), , Nov-22, Volume: 342, Issue:6161, 2013
Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.Science (New York, N.Y.), , Nov-22, Volume: 342, Issue:6161, 2013
Silencing synuclein at the synapse with PLK2.Proceedings of the National Academy of Sciences of the United States of America, , Oct-08, Volume: 110, Issue:41, 2013
Saposin C protects glucocerebrosidase against α-synuclein inhibition.Biochemistry, , Oct-15, Volume: 52, Issue:41, 2013
Endonuclease-G and the pathways to dopaminergic neurodegeneration: a question of location?The EMBO journal, , Nov-27, Volume: 32, Issue:23, 2013
Gender differences in Parkinson's disease: focus on plasma α-synuclein.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 120, Issue:8, 2013
In vivo electrophysiology of nigral and thalamic neurons in alpha-synuclein-overexpressing mice highlights differences from toxin-based models of parkinsonism.Journal of neurophysiology, , Volume: 110, Issue:12, 2013
α-Synuclein misfolding assessed with single molecule AFM force spectroscopy: effect of pathogenic mutations.Biochemistry, , Oct-22, Volume: 52, Issue:42, 2013
The secreted oligomeric form of α-synuclein affects multiple steps of membrane trafficking.FEBS letters, , Mar-01, Volume: 587, Issue:5, 2013
[The role of extracellular α-synuclein in molecular mechanisms of cell death].Postepy higieny i medycyny doswiadczalnej (Online), , Nov-04, Volume: 67, 2013
Dexamethasone induces the expression of LRRK2 and α-synuclein, two genes that when mutated cause Parkinson's disease in an autosomal dominant manner.BMB reports, , Volume: 46, Issue:9, 2013
Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice.BMC neuroscience, , Nov-05, Volume: 14, 2013
Mechanistic insight into the relationship between N-terminal acetylation of α-synuclein and fibril formation rates by NMR and fluorescence.PloS one, , Volume: 8, Issue:9, 2013
Elevated alpha-synuclein impairs innate immune cell function and provides a potential peripheral biomarker for Parkinson's disease.PloS one, , Volume: 8, Issue:8, 2013
α-synuclein imaging: a critical need for Parkinson's disease research.Journal of Parkinson's disease, , Volume: 3, Issue:4, 2013
[Impacts of electroacupuncture on ubiquitin-proteasome system in rats with Parkinson's disease].Zhongguo zhen jiu = Chinese acupuncture & moxibustion, , Volume: 33, Issue:8, 2013
Parkinson's disease: dopaminergic nerve cell model is consistent with experimental finding of increased extracellular transport of α-synuclein.BMC neuroscience, , Nov-06, Volume: 14, 2013
Off-pathway α-synuclein oligomers seem to alter α-synuclein turnover in a cell model but lack seeding capability in vivo.Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, , Volume: 20, Issue:4, 2013
SMG1 identified as a regulator of Parkinson's disease-associated alpha-synuclein through siRNA screening.PloS one, , Volume: 8, Issue:10, 2013
Alpha-synuclein pathology and axonal degeneration of the peripheral motor nerves innervating pharyngeal muscles in Parkinson disease.Journal of neuropathology and experimental neurology, , Volume: 72, Issue:2, 2013
Submandibular gland biopsy for the diagnosis of Parkinson disease.Journal of neuropathology and experimental neurology, , Volume: 72, Issue:2, 2013
Neuroprotective effects of protocatechuic aldehyde against neurotoxin-induced cellular and animal models of Parkinson's disease.PloS one, , Volume: 8, Issue:10, 2013
Influence of gold nanoparticles on the kinetics of α-synuclein aggregation.Nano letters, , Volume: 13, Issue:12, 2013
A single dopamine pathway underlies progressive locomotor deficits in a Drosophila model of Parkinson disease.Cell reports, , Nov-27, Volume: 5, Issue:4, 2013
Nuclear translocation of alpha-synuclein increases susceptibility of MES23.5 cells to oxidative stress.Brain research, , Mar-15, Volume: 1500, 2013
Aggregation and neurotoxicity of recombinant α-synuclein aggregates initiated by dimerization.Molecular neurodegeneration, , Jan-22, Volume: 8, 2013
The function of α-synuclein.Neuron, , Sep-18, Volume: 79, Issue:6, 2013
Phenotypic screens for compounds that target the cellular pathologies underlying Parkinson's disease.Drug discovery today. Technologies, ,Spring, Volume: 10, Issue:1, 2013
The Parkinson's disease-associated H50Q mutation accelerates α-Synuclein aggregation in vitro.Biochemistry, , Oct-08, Volume: 52, Issue:40, 2013
Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology.Proceedings of the National Academy of Sciences of the United States of America, , Oct-29, Volume: 110, Issue:44, 2013
Temperature-dependent structural changes of Parkinson's alpha-synuclein reveal the role of pre-existing oligomers in alpha-synuclein fibrillization.PloS one, , Volume: 8, Issue:1, 2013
An ERcentric view of Parkinson's disease.Trends in molecular medicine, , Volume: 19, Issue:3, 2013
Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells.International journal of molecular sciences, , Nov-15, Volume: 14, Issue:11, 2013
ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies.Acta neuropathologica communications, , May-09, Volume: 1, 2013
α-Synuclein and mitochondrial dysfunction in Parkinson's disease.Molecular neurobiology, , Volume: 47, Issue:2, 2013
The role of oxidative stress in Parkinson's disease.Journal of Parkinson's disease, , Volume: 3, Issue:4, 2013
Emerging insights into the mechanistic link between α-synuclein and glucocerebrosidase in Parkinson's disease.Biochemical Society transactions, , Volume: 41, Issue:6, 2013
Enteric alpha-synuclein expression is increased in Parkinson's disease but not Alzheimer's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:2, 2013
Disturbed sleep in Parkinson's disease: anatomical and pathological correlates.Neuropathology and applied neurobiology, , Volume: 39, Issue:6, 2013
α-Synuclein as a ferrireductase.Biochemical Society transactions, , Volume: 41, Issue:6, 2013
Association between early-onset Parkinson disease and 22q11.2 deletion syndrome: identification of a novel genetic form of Parkinson disease and its clinical implications.JAMA neurology, , Volume: 70, Issue:11, 2013
rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration.Molecular neurodegeneration, , Nov-25, Volume: 8, 2013
The association between lysosomal protein glucocerebrosidase and Parkinson's disease.European review for medical and pharmacological sciences, , Volume: 17, Issue:2, 2013
Can intrabodies serve as neuroprotective therapies for Parkinson's disease? Beginning thoughts.Journal of Parkinson's disease, , Volume: 3, Issue:4, 2013
Limelight on alpha-synuclein: pathological and mechanistic implications in neurodegeneration.Journal of Parkinson's disease, , Volume: 3, Issue:4, 2013
Neural and immune mechanisms in the pathogenesis of Parkinson's disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 8, Issue:1, 2013
Parkinson disease: from pathology to molecular disease mechanisms.Free radical biology & medicine, , Volume: 62, 2013
Evaluation of potential infectivity of Alzheimer and Parkinson disease proteins in recipients of cadaver-derived human growth hormone.JAMA neurology, , Volume: 70, Issue:4, 2013
A longitudinal study on α-synuclein in blood plasma as a biomarker for Parkinson's disease.Scientific reports, , Volume: 3, 2013
Pale body-like inclusion formation and neurodegeneration following depletion of 26S proteasomes in mouse brain neurones are independent of α-synuclein.PloS one, , Volume: 8, Issue:1, 2013
Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo.Proceedings of the National Academy of Sciences of the United States of America, , Oct-08, Volume: 110, Issue:41, 2013
Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies.PloS one, , Volume: 8, Issue:1, 2013
Assessing the subcellular dynamics of alpha-synuclein using photoactivation microscopy.Molecular neurobiology, , Volume: 47, Issue:3, 2013
The genetics of Parkinson's disease: progress and therapeutic implications.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:1, 2013
Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription.Cell, , Dec-05, Volume: 155, Issue:6, 2013
SUMO and Parkinson's disease.Neuromolecular medicine, , Volume: 15, Issue:4, 2013
Parkinson's disease and alpha synuclein: is Parkinson's disease a prion-like disorder?Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:1, 2013
Association of cerebrospinal fluid β-amyloid 1-42, T-tau, P-tau181, and α-synuclein levels with clinical features of drug-naive patients with early Parkinson disease.JAMA neurology, , Volume: 70, Issue:10, 2013
Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathies.Acta neuropathologica communications, , Dec-05, Volume: 1, 2013
Mapping the subcellular distribution of α-synuclein in neurons using genetically encoded probes for correlated light and electron microscopy: implications for Parkinson's disease pathogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-06, Volume: 33, Issue:6, 2013
[Hyperbranching axons template α-synuclein deposits and non-localizing clinical manifestations of Parkinson disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 65, Issue:12, 2013
Alpha-synuclein post-translational modifications as potential biomarkers for Parkinson disease and other synucleinopathies.Molecular & cellular proteomics : MCP, , Volume: 12, Issue:12, 2013
Modulation of α-synuclein fibrillization by ring-fused 2-pyridones: templation and inhibition involve oligomers with different structure.Archives of biochemistry and biophysics, , Apr-15, Volume: 532, Issue:2, 2013
Ubiquitination increases parkin activity to promote autophagic α-synuclein clearance.PloS one, , Volume: 8, Issue:12, 2013
Parkinson's disease: "Braak" to the future.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:9, 2013
Treatment implications of the altered cytokine-insulin axis in neurodegenerative disease.Biochemical pharmacology, , Oct-01, Volume: 86, Issue:7, 2013
Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice.Molecular brain, , Aug-11, Volume: 6, 2013
The benefits of humanized yeast models to study Parkinson's disease.Oxidative medicine and cellular longevity, , Volume: 2013, 2013
Autophagic impairment contributes to systemic inflammation-induced dopaminergic neuron loss in the midbrain.PloS one, , Volume: 8, Issue:8, 2013
Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease.PloS one, , Volume: 8, Issue:8, 2013
Alpha-synuclein: one key opens many locks.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:9, 2013
Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice.Acta neuropathologica, , Volume: 126, Issue:4, 2013
α-Synuclein is a pathological link and therapeutic target for Parkinson's disease and traumatic brain injury.Medical hypotheses, , Volume: 81, Issue:4, 2013
Novel A18T and pA29S substitutions in α-synuclein may be associated with sporadic Parkinson's disease.Parkinsonism & related disorders, , Volume: 19, Issue:11, 2013
A peroxisome biogenesis deficiency prevents the binding of alpha-synuclein to lipid droplets in lipid-loaded yeast.Biochemical and biophysical research communications, , Aug-23, Volume: 438, Issue:2, 2013
Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies.Nature reviews. Neuroscience, , Volume: 14, Issue:9, 2013
The role of α-synuclein in neurodegenerative diseases: from molecular pathways in disease to therapeutic approaches.Current Alzheimer research, , Volume: 10, Issue:6, 2013
Deregulation of calcium homeostasis mediates secreted α-synuclein-induced neurotoxicity.Neurobiology of aging, , Volume: 34, Issue:12, 2013
C9ORF72 expansions, parkinsonism, and Parkinson disease: a clinicopathologic study.Neurology, , Aug-27, Volume: 81, Issue:9, 2013
Analysis of genome-wide association study-linked loci in Parkinson's disease of Mainland China.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:13, 2013
The glial marker YKL-40 is decreased in synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:13, 2013
[The relevance between the import roles for alpha-synuclein in neurotransmitter release and the progress of Parkinsons disease].Sheng li ke xue jin zhan [Progress in physiology], , Volume: 44, Issue:6, 2013
Membrane bound α-synuclein is fully embedded in the lipid bilayer while segments with higher flexibility remain.FEBS letters, , Aug-19, Volume: 587, Issue:16, 2013
SNCA, LRRK2, MAPT polymorphisms and Parkinson's disease in Russia.Parkinsonism & related disorders, , Volume: 19, Issue:11, 2013
Distinct α-synuclein strains differentially promote tau inclusions in neurons.Cell, , Jul-03, Volume: 154, Issue:1, 2013
Adsorption of α-synuclein to supported lipid bilayers: positioning and role of electrostatics.ACS chemical neuroscience, , Oct-16, Volume: 4, Issue:10, 2013
Binding of Dopamine to Alpha-Synuclein is Mediated by Specific Conformational States.Journal of the American Society for Mass Spectrometry, , Volume: 24, Issue:9, 2013
Exosomes of BV-2 cells induced by alpha-synuclein: important mediator of neurodegeneration in PD.Neuroscience letters, , Aug-26, Volume: 548, 2013
α-Synuclein vaccination prevents the accumulation of parkinson disease-like pathologic inclusions in striatum in association with regulatory T cell recruitment in a rat model.Journal of neuropathology and experimental neurology, , Volume: 72, Issue:7, 2013
Parkinson disease affects peripheral sensory nerves in the pharynx.Journal of neuropathology and experimental neurology, , Volume: 72, Issue:7, 2013
Applying chaperones to protein-misfolding disorders: molecular chaperones against α-synuclein in Parkinson's disease.International journal of biological macromolecules, , Volume: 60, 2013
Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases.Neurobiology of disease, , Volume: 58, 2013
Castration induces Parkinson disease pathologies in young male mice via inducible nitric-oxide synthase.The Journal of biological chemistry, , Jul-19, Volume: 288, Issue:29, 2013
Reprint of: revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease-resemblance to the effect of amphetamine drugs of abuse.Free radical biology & medicine, , Volume: 62, 2013
MHCII is required for α-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jun-05, Volume: 33, Issue:23, 2013
SNCA rs356219 variant increases risk of sporadic Parkinson's disease in ethnic Chinese.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, , Volume: 162B, Issue:5, 2013
Conformational templating of α-synuclein aggregates in neuronal-glial cultures.Molecular neurodegeneration, , May-28, Volume: 8, 2013
Tenuigenin attenuates α-synuclein-induced cytotoxicity by down-regulating polo-like kinase 3.CNS neuroscience & therapeutics, , Volume: 19, Issue:9, 2013
Mitochondria and quality control defects in a mouse model of Gaucher disease--links to Parkinson's disease.Cell metabolism, , Jun-04, Volume: 17, Issue:6, 2013
Caudo-rostral brain spreading of α-synuclein through vagal connections.EMBO molecular medicine, , Volume: 5, Issue:7, 2013
RNA interference targeting α-synuclein attenuates methamphetamine-induced neurotoxicity in SH-SY5Y cells.Brain research, , Jul-12, Volume: 1521, 2013
Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 27, Issue:9, 2013
A mir-153 binding site variation in SNCA in a patient with Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:12, 2013
Somatic alpha-synuclein mutations in Parkinson's disease: hypothesis and preliminary data.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:6, 2013
The many faces of alpha-synuclein mutations.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:6, 2013
SNCA: major genetic modifier of age at onset of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:9, 2013
FBXO7 immunoreactivity in α-synuclein-containing inclusions in Parkinson disease and multiple system atrophy.Journal of neuropathology and experimental neurology, , Volume: 72, Issue:6, 2013
The remarkable conformational plasticity of alpha-synuclein: blessing or curse?Trends in molecular medicine, , Volume: 19, Issue:6, 2013
Small molecules interacting with α-synuclein: antiaggregating and cytoprotective properties.Amino acids, , Volume: 45, Issue:2, 2013
A blood-brain barrier (BBB) disrupter is also a potent α-synuclein (α-syn) aggregation inhibitor: a novel dual mechanism of mannitol for the treatment of Parkinson disease (PD).The Journal of biological chemistry, , Jun-14, Volume: 288, Issue:24, 2013
Molecular ageing of alpha- and Beta-synucleins: protein damage and repair mechanisms.PloS one, , Volume: 8, Issue:4, 2013
TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease.PloS one, , Volume: 8, Issue:4, 2013
Development and screening of contrast agents for in vivo imaging of Parkinson's disease.Molecular imaging and biology, , Volume: 15, Issue:5, 2013
Parkinsonism, dementia and glucocerebrosidase mutations.Journal of neurology, , Volume: 260, Issue:5, 2013
High-resolution survey in familial Parkinson disease genes reveals multiple independent copy number variation events in PARK2.Human mutation, , Volume: 34, Issue:8, 2013
Alpha-synuclein and intracellular trafficking: impact on the spreading of Parkinson's disease pathology.Journal of molecular medicine (Berlin, Germany), , Volume: 91, Issue:6, 2013
TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity.Proceedings of the National Academy of Sciences of the United States of America, , May-07, Volume: 110, Issue:19, 2013
Inhibition of formation of α-synuclein inclusions by mannosylglycerate in a yeast model of Parkinson's disease.Biochimica et biophysica acta, , Volume: 1830, Issue:8, 2013
Structures and free energy landscapes of the A53T mutant-type α-synuclein protein and impact of A53T mutation on the structures of the wild-type α-synuclein protein with dynamics.ACS chemical neuroscience, , Jul-17, Volume: 4, Issue:7, 2013
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease.Acta neuropathologica, , Volume: 125, Issue:6, 2013
Crosstalk between the proteasome system and autophagy in the clearance of α-synuclein.Acta pharmacologica Sinica, , Volume: 34, Issue:5, 2013
α-Synuclein: the long distance runner.Brain pathology (Zurich, Switzerland), , Volume: 23, Issue:3, 2013
Loss of β-glucocerebrosidase activity does not affect alpha-synuclein levels or lysosomal function in neuronal cells.PloS one, , Volume: 8, Issue:4, 2013
Rasagiline ameliorates olfactory deficits in an alpha-synuclein mouse model of Parkinson's disease.PloS one, , Volume: 8, Issue:4, 2013
Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease.Neurobiology of disease, , Volume: 56, 2013
Lewy body pathology is associated with mitochondrial DNA damage in Parkinson's disease.Neurobiology of aging, , Volume: 34, Issue:9, 2013
Prolyl oligopeptidase colocalizes with α-synuclein, β-amyloid, tau protein and astroglia in the post-mortem brain samples with Parkinson's and Alzheimer's diseases.Neuroscience, , Jul-09, Volume: 242, 2013
Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function.PloS one, , Volume: 8, Issue:4, 2013
Behavioral testing regimens in genetic-based animal models of Parkinson's disease: cogencies and caveats.Neuroscience and biobehavioral reviews, , Volume: 37, Issue:5, 2013
[Neurotoxicity of pesticides: its relationship with neurodegenerative diseases].Medecine sciences : M/S, , Volume: 29, Issue:3, 2013
Specific pesticide-dependent increases in α-synuclein levels in human neuroblastoma (SH-SY5Y) and melanoma (SK-MEL-2) cell lines.Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 133, Issue:2, 2013
Lewy body-like α-synuclein aggregates resist degradation and impair macroautophagy.The Journal of biological chemistry, , May-24, Volume: 288, Issue:21, 2013
Chronic intranasal deferoxamine ameliorates motor defects and pathology in the α-synuclein rAAV Parkinson's model.Experimental neurology, , Volume: 247, 2013
α-Synuclein and mitochondria: partners in crime?Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 10, Issue:3, 2013
On-surface aggregation of α-synuclein at nanomolar concentrations results in two distinct growth mechanisms.ACS chemical neuroscience, , Mar-20, Volume: 4, Issue:3, 2013
Curcumin modulates α-synuclein aggregation and toxicity.ACS chemical neuroscience, , Mar-20, Volume: 4, Issue:3, 2013
Early Alzheimer's and Parkinson's disease pathology in urban children: Friend versus Foe responses--it is time to face the evidence.BioMed research international, , Volume: 2013, 2013
Genetic susceptibility loci, environmental exposures, and Parkinson's disease: a case-control study of gene-environment interactions.Parkinsonism & related disorders, , Volume: 19, Issue:6, 2013
α-Synuclein-mediated defense against oxidative stress via modulation of glutathione peroxidase.Biochimica et biophysica acta, , Volume: 1834, Issue:6, 2013
Neuroimmunological processes in Parkinson's disease and their relation to α-synuclein: microglia as the referee between neuronal processes and peripheral immunity.ASN neuro, , Apr-30, Volume: 5, Issue:2, 2013
Site-specific perturbations of alpha-synuclein fibril structure by the Parkinson's disease associated mutations A53T and E46K.PloS one, , Volume: 8, Issue:3, 2013
Neuroprotective effects of aqueous extracts of Uncaria tomentosa: Insights from 6-OHDA induced cell damage and transgenic Caenorhabditis elegans model.Neurochemistry international, , Volume: 62, Issue:7, 2013
Exploring the accessible conformations of N-terminal acetylated α-synuclein.FEBS letters, , Apr-17, Volume: 587, Issue:8, 2013
Levodopa gains psychostimulant-like properties after nigral dopaminergic loss.Annals of neurology, , Volume: 74, Issue:1, 2013
Influence of microRNA deregulation on chaperone-mediated autophagy and α-synuclein pathology in Parkinson's disease.Cell death & disease, , Mar-14, Volume: 4, 2013
Valproic acid ameliorates C. elegans dopaminergic neurodegeneration with implications for ERK-MAPK signaling.Neuroscience letters, , Apr-29, Volume: 541, 2013
Dopamine-mediated oxidation of methionine 127 in α-synuclein causes cytotoxicity and oligomerization of α-synuclein.PloS one, , Volume: 8, Issue:2, 2013
Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:6, 2013
Role of α-synuclein aggregation and the nuclear factor E2-related factor 2/heme oxygenase-1 pathway in iron-induced neurotoxicity.The international journal of biochemistry & cell biology, , Volume: 45, Issue:6, 2013
Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies.Journal of neurochemistry, , Volume: 125, Issue:4, 2013
Mind the gut: secretion of α-synuclein by enteric neurons.Journal of neurochemistry, , Volume: 125, Issue:4, 2013
Melatonin prevents dopaminergic cell loss induced by lentiviral vectors expressing A30P mutant alpha-synuclein.Histology and histopathology, , Volume: 28, Issue:8, 2013
A novel α-synuclein missense mutation in Parkinson disease.Neurology, , Mar-12, Volume: 80, Issue:11, 2013
May the evaluation of nitrosative stress through selective increase of 3-nitrotyrosine proteins other than nitroalbumin and dominant tyrosine-125/136 nitrosylation of serum α-synuclein serve for diagnosis of sporadic Parkinson's disease?Antioxidants & redox signaling, , Sep-20, Volume: 19, Issue:9, 2013
A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats.Brain : a journal of neurology, , Volume: 136, Issue:Pt 2, 2013
Binding of the radioligand SIL23 to α-synuclein fibrils in Parkinson disease brain tissue establishes feasibility and screening approaches for developing a Parkinson disease imaging agent.PloS one, , Volume: 8, Issue:2, 2013
α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?Acta neuropathologica, , Volume: 125, Issue:5, 2013
Phosphorylation of α-synuclein protein at Ser-129 reduces neuronal dysfunction by lowering its membrane binding property in Caenorhabditis elegans.The Journal of biological chemistry, , Mar-02, Volume: 287, Issue:10, 2012
Animal models of the non-motor features of Parkinson's disease.Neurobiology of disease, , Volume: 46, Issue:3, 2012
A DNA resequencing array for genes involved in Parkinson's disease.Parkinsonism & related disorders, , Volume: 18, Issue:4, 2012
MicroRNAs in Parkinson's disease.Neurobiology of disease, , Volume: 46, Issue:2, 2012
Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation.The FEBS journal, , Volume: 279, Issue:6, 2012
Animal models of Parkinson's disease.The FEBS journal, , Volume: 279, Issue:7, 2012
Mechanisms of protein oligomerization: inhibitor of functional amyloids templates α-synuclein fibrillation.Journal of the American Chemical Society, , Feb-22, Volume: 134, Issue:7, 2012
No evidence for differential methylation of α-synuclein in leukocyte DNA of Parkinson's disease patients.Movement disorders : official journal of the Movement Disorder Society, , Volume: 27, Issue:4, 2012
Head injury, α-synuclein Rep1, and Parkinson's disease.Annals of neurology, , Volume: 71, Issue:1, 2012
An evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology.Journal of neurology, neurosurgery, and psychiatry, , Volume: 83, Issue:4, 2012
Alpha-synuclein's degradation in vivo: opening a new (cranial) window on the roles of degradation pathways in Parkinson disease.Autophagy, , Feb-01, Volume: 8, Issue:2, 2012
Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-01, Volume: 32, Issue:5, 2012
Brain banks as key part of biochemical and molecular studies on cerebral cortex involvement in Parkinson's disease.The FEBS journal, , Volume: 279, Issue:7, 2012
The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity.PLoS genetics, , Volume: 8, Issue:2, 2012
Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-08, Volume: 32, Issue:6, 2012
Lewy-like aggregation of α-synuclein reduces protein phosphatase 2A activity in vitro and in vivo.Neuroscience, , Apr-05, Volume: 207, 2012
Phosphorylated α-synuclein in Parkinson's disease.Science translational medicine, , Feb-15, Volume: 4, Issue:121, 2012
SNP rs356219 of the α-synuclein (SNCA) gene is associated with Parkinson's disease in a Chinese Han population.Parkinsonism & related disorders, , Volume: 18, Issue:5, 2012
A progressive mouse model of Parkinson's disease: the Thy1-aSyn ("Line 61") mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 9, Issue:2, 2012
Synaptic dysfunction in Parkinson's disease.Advances in experimental medicine and biology, , Volume: 970, 2012
Excess α-synuclein worsens disease in mice lacking ubiquitin carboxy-terminal hydrolase L1.Scientific reports, , Volume: 2, 2012
α-Synuclein in Parkinson's disease.Cold Spring Harbor perspectives in medicine, , Volume: 2, Issue:2, 2012
Cognitive deficits in a mouse model of pre-manifest Parkinson's disease.The European journal of neuroscience, , Volume: 35, Issue:6, 2012
α-Synuclein fate: proteasome or autophagy?Autophagy, , Volume: 8, Issue:3, 2012
Adenosine A2A receptor gene disruption protects in an α-synuclein model of Parkinson's disease.Annals of neurology, , Volume: 71, Issue:2, 2012
Phosphorylated α-synuclein as a potential biomarker for Parkinson's disease and related disorders.Expert review of molecular diagnostics, , Volume: 12, Issue:2, 2012
An antibody with high reactivity for disease-associated α-synuclein reveals extensive brain pathology.Acta neuropathologica, , Volume: 124, Issue:1, 2012
Exon dosage variations in Brazilian patients with Parkinson's disease: analysis of SNCA, PARKIN, PINK1 and DJ-1 genes.Disease markers, , Volume: 32, Issue:3, 2012
Increased expression of α-synuclein by SNCA duplication is associated with resistance to toxic stimuli.Journal of molecular neuroscience : MN, , Volume: 47, Issue:2, 2012
Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-07, Volume: 32, Issue:10, 2012
Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-07, Volume: 32, Issue:10, 2012
Semisynthetic, site-specific ubiquitin modification of α-synuclein reveals differential effects on aggregation.Journal of the American Chemical Society, , Mar-28, Volume: 134, Issue:12, 2012
Relationship between mitochondria and α-synuclein: a study of single substantia nigra neurons.Archives of neurology, , Volume: 69, Issue:3, 2012
Partial trisomy 4q associated with young-onset dopa-responsive parkinsonism.Archives of neurology, , Volume: 69, Issue:3, 2012
SNCA polymorphisms, smoking, and sporadic Parkinson's disease in Japanese.Parkinsonism & related disorders, , Volume: 18, Issue:5, 2012
The dietary supplementation of nordihydroguaiaretic acid (NDGA) delayed the loss of climbing ability in Drosophila model of Parkinson's disease.Journal of dietary supplements, , Volume: 9, Issue:1, 2012
Glucose regulated protein 78 diminishes α-synuclein neurotoxicity in a rat model of Parkinson disease.Molecular therapy : the journal of the American Society of Gene Therapy, , Volume: 20, Issue:7, 2012
The SNCA (A53T, A30P, E46K) and LRRK2 (G2019S) mutations are rare cause of Parkinson's disease in South Indian patients.Parkinsonism & related disorders, , Volume: 18, Issue:6, 2012
Analysis of LRRK2, SNCA, Parkin, PINK1, and DJ-1 in Zambian patients with Parkinson's disease.Parkinsonism & related disorders, , Volume: 18, Issue:5, 2012
Critical role of truncated α-synuclein and aggregates in Parkinson's disease and incidental Lewy body disease.Brain pathology (Zurich, Switzerland), , Volume: 22, Issue:6, 2012
The molecular basis of dopaminergic brain imaging in Parkinson's disease.The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of..., , Volume: 56, Issue:1, 2012
Development of electrochemiluminescence-based singleplex and multiplex assays for the quantification of α-synuclein and other proteins in cerebrospinal fluid.Methods (San Diego, Calif.), , Volume: 56, Issue:4, 2012
The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease.The Journal of experimental medicine, , Apr-09, Volume: 209, Issue:4, 2012
The role of autophagy in Parkinson's disease.Cold Spring Harbor perspectives in medicine, , Volume: 2, Issue:4, 2012
Parkinson's disease: gene therapies.Cold Spring Harbor perspectives in medicine, , Volume: 2, Issue:4, 2012
α-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion.Neuroscience research, , Volume: 73, Issue:2, 2012
Targeting intracellular and extracellular alpha-synuclein as a therapeutic strategy in Parkinson's disease and other synucleinopathies.Expert opinion on therapeutic targets, , Volume: 16, Issue:4, 2012
The role of the GABA(B) receptor and calcium channels in a Drosophila model of Parkinson's Disease.Neuroscience letters, , May-16, Volume: 516, Issue:2, 2012
Molecular insights into Parkinson's disease.Progress in molecular biology and translational science, , Volume: 107, 2012
Targeting alpha-synuclein for the treatment of Parkinson's disease.CNS & neurological disorders drug targets, , Volume: 11, Issue:2, 2012
New agents promote neuroprotection in Parkinson's disease models.CNS & neurological disorders drug targets, , Jun-01, Volume: 11, Issue:4, 2012
A synopsis on the role of tyrosine hydroxylase in Parkinson's disease.CNS & neurological disorders drug targets, , Jun-01, Volume: 11, Issue:4, 2012
[Role of microglial activation induced by α-synuclein in pathogenesis of Parkinson's disease].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, , Volume: 41, Issue:2, 2012
α-Synuclein phosphorylation as a therapeutic target in Parkinson's disease.Reviews in the neurosciences, , Mar-21, Volume: 23, Issue:2, 2012
Two different binding modes of α-synuclein to lipid vesicles depending on its aggregation state.Biophysical journal, , Apr-04, Volume: 102, Issue:7, 2012
Beyond α-synuclein transfer: pathology propagation in Parkinson's disease.Trends in molecular medicine, , Volume: 18, Issue:5, 2012
Biochemical premotor biomarkers for Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Apr-15, Volume: 27, Issue:5, 2012
α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease.Human molecular genetics, , Jul-15, Volume: 21, Issue:14, 2012
Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy.PloS one, , Volume: 7, Issue:4, 2012
Leucine-rich repeat kinase 2 and alternative splicing in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 27, Issue:8, 2012
Detection of α-synuclein aggregates by fluorescence microscopy.Rejuvenation research, , Volume: 15, Issue:2, 2012
Modeling Parkinson's disease using induced pluripotent stem cells.Current neurology and neuroscience reports, , Volume: 12, Issue:3, 2012
Is alpha-synuclein in the colon a biomarker for premotor Parkinson's disease? Evidence from 3 cases.Movement disorders : official journal of the Movement Disorder Society, , Volume: 27, Issue:6, 2012
Analysis of colonic alpha-synuclein pathology in multiple system atrophy.Parkinsonism & related disorders, , Volume: 18, Issue:7, 2012
From α-synuclein to synaptic dysfunctions: new insights into the pathophysiology of Parkinson's disease.Brain research, , Oct-02, Volume: 1476, 2012
α-Synuclein mRNA and soluble α-synuclein protein levels in post-mortem brain from patients with Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease.Brain research, , Jun-12, Volume: 1459, 2012
Mechanisms underlying the impairment of hippocampal long-term potentiation and memory in experimental Parkinson's disease.Brain : a journal of neurology, , Volume: 135, Issue:Pt 6, 2012
[Role of septin cytoskeleton in dopaminergic neurotransmission and neurodegeneration].Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, , Volume: 32, Issue:1, 2012
N-terminal acetylation of α-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer.Protein science : a publication of the Protein Society, , Volume: 21, Issue:7, 2012
Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson's disease models.Critical reviews in toxicology, , Volume: 42, Issue:7, 2012
Differential inhibition of α-synuclein oligomeric and fibrillar assembly in parkinson's disease model by cinnamon extract.Biochimica et biophysica acta, , Volume: 1820, Issue:10, 2012
α-Synuclein expression is modulated at the translational level by iron.Neuroreport, , Jun-20, Volume: 23, Issue:9, 2012
Current status of tyrosine hydroxylase in management of Parkinson's disease.CNS & neurological disorders drug targets, , Jun-01, Volume: 11, Issue:4, 2012
A brief overview of tyrosine hydroxylase and α-synuclein in the Parkinsonian brain.CNS & neurological disorders drug targets, , Jun-01, Volume: 11, Issue:4, 2012
α-Synuclein genetic variants predict faster motor symptom progression in idiopathic Parkinson disease.PloS one, , Volume: 7, Issue:5, 2012
Variants in the 3'UTR of SNCA do not affect miRNA-433 binding and alpha-synuclein expression.European journal of human genetics : EJHG, , Volume: 20, Issue:12, 2012
Proteolytic cleavage of extracellular α-synuclein by plasmin: implications for Parkinson disease.The Journal of biological chemistry, , Jul-20, Volume: 287, Issue:30, 2012
Genetics and epigenetics of Parkinson's disease.TheScientificWorldJournal, , Volume: 2012, 2012
A colonic biomarker of Parkinson's disease?Movement disorders : official journal of the Movement Disorder Society, , Volume: 27, Issue:6, 2012
Lewy pathology in gastric and duodenal biopsies in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 27, Issue:6, 2012
Evaluation of the Braak hypothesis: how far can it explain the pathogenesis of Parkinson's disease?Expert review of neurotherapeutics, , Volume: 12, Issue:6, 2012
MiRNAs and neural stem cells: a team to treat Parkinson's disease?RNA biology, , Volume: 9, Issue:6, 2012
Age at onset in LRRK2-associated PD is modified by SNCA variants.Journal of molecular neuroscience : MN, , Volume: 48, Issue:1, 2012
Atomic force microscopy under controlled conditions reveals structure of C-terminal region of α-synuclein in amyloid fibrils.ACS nano, , Jul-24, Volume: 6, Issue:7, 2012
Selection of DNA aptamers that recognize α-synuclein oligomers using a competitive screening method.Analytical chemistry, , Jul-03, Volume: 84, Issue:13, 2012
The role of alpha-synuclein oligomerization and aggregation in cellular and animal models of Parkinson's disease.PloS one, , Volume: 7, Issue:6, 2012
Oxidative stress in Alzheimer's and Parkinson's diseases: insights from the yeast Saccharomyces cerevisiae.Oxidative medicine and cellular longevity, , Volume: 2012, 2012
Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease.Free radical biology & medicine, , Aug-15, Volume: 53, Issue:4, 2012
[The role of proteins in neurodegenerative disease].Postepy higieny i medycyny doswiadczalnej (Online), , Apr-16, Volume: 66, 2012
Cognitive dysfunction and depression in Parkinson's disease: what can be learned from rodent models?The European journal of neuroscience, , Volume: 35, Issue:12, 2012
Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein.The Journal of biological chemistry, , Aug-17, Volume: 287, Issue:34, 2012
Alpha-synuclein transgenic mice display age-related slowing of gastrointestinal motility associated with transgene expression in the vagal system.Neurobiology of disease, , Volume: 48, Issue:1, 2012
Aggregate clearance of α-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome.The Journal of biological chemistry, , Aug-10, Volume: 287, Issue:33, 2012
Do α-synuclein vector injections provide a better model of Parkinson's disease than the classic 6-hydroxydopamine model?Experimental neurology, , Volume: 237, Issue:1, 2012
Cellular and molecular mechanisms of antioxidants in Parkinson's disease.Nutritional neuroscience, , Volume: 15, Issue:3, 2012
Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo.PloS one, , Volume: 7, Issue:6, 2012
Protein degradation pathways in Parkinson's disease: curse or blessing.Acta neuropathologica, , Volume: 124, Issue:2, 2012
Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein.Experimental neurology, , Volume: 237, Issue:2, 2012
Dynamic modelling of protein and oxidative metabolisms simulates the pathogenesis of Parkinson's disease.IET systems biology, , Volume: 6, Issue:3, 2012
Feedback motif for the pathogenesis of Parkinson's disease.IET systems biology, , Volume: 6, Issue:3, 2012
Remodeling of lipid vesicles into cylindrical micelles by α-synuclein in an extended α-helical conformation.The Journal of biological chemistry, , Aug-24, Volume: 287, Issue:35, 2012
The Parkinson's disease-related genes act in mitochondrial homeostasis.Neuroscience and biobehavioral reviews, , Volume: 36, Issue:9, 2012
Methamphetamine binds to α-synuclein and causes a conformational change which can be detected by nanopore analysis.FEBS letters, , Sep-21, Volume: 586, Issue:19, 2012
α-Synuclein modulates neurite outgrowth by interacting with SPTBN1.Biochemical and biophysical research communications, , Aug-03, Volume: 424, Issue:3, 2012
First therapy targeting Parkinson's proteins enters clinical trials.Nature medicine, , Jul-06, Volume: 18, Issue:7, 2012
Biomarkers in Parkinson's disease: an update.Current opinion in neurology, , Volume: 25, Issue:4, 2012
Effect of L-ascorbic Acid on the climbing ability and protein levels in the brain of Drosophila model of Parkinson's disease.The International journal of neuroscience, , Volume: 122, Issue:12, 2012
Phosphorylation of α-synuclein is crucial in compensating for proteasomal dysfunction.Biochemical and biophysical research communications, , Aug-03, Volume: 424, Issue:3, 2012
A model of nitric oxide induced α-synuclein misfolding in Parkinson's disease.Neuroscience letters, , Aug-15, Volume: 523, Issue:2, 2012
Mice overexpressing wild-type human alpha-synuclein display alterations in colonic myenteric ganglia and defecation.Neurogastroenterology and motility, , Volume: 24, Issue:9, 2012
Inflammation in Parkinson's disease: cause or consequence?Movement disorders : official journal of the Movement Disorder Society, , Volume: 27, Issue:9, 2012
The genetics and neuropathology of Parkinson's disease.Acta neuropathologica, , Volume: 124, Issue:3, 2012
Cognitive impairment in patients with Parkinson's disease: diagnosis, biomarkers, and treatment.The Lancet. Neurology, , Volume: 11, Issue:8, 2012
Pathologic accumulation of α-synuclein and Aβ in Parkinson disease patients with dementia.Archives of neurology, , Volume: 69, Issue:10, 2012
Alpha-synuclein: from secretion to dysfunction and death.Cell death & disease, , Jul-19, Volume: 3, 2012
α-Synuclein induces alterations in adult neurogenesis in Parkinson disease models via p53-mediated repression of Notch1.The Journal of biological chemistry, , Sep-14, Volume: 287, Issue:38, 2012
Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic.Human molecular genetics, , Nov-01, Volume: 21, Issue:21, 2012
Identification of protein interfaces between α-synuclein, the principal component of Lewy bodies in Parkinson disease, and the molecular chaperones human Hsc70 and the yeast Ssa1p.The Journal of biological chemistry, , Sep-21, Volume: 287, Issue:39, 2012
Novel one-step immunoassays to quantify α-synuclein: applications for biomarker development and high-throughput screening.The Journal of biological chemistry, , Sep-28, Volume: 287, Issue:40, 2012
Silencing of Parkinson's disease-associated genes with artificial mirtron mimics of miR-1224.Nucleic acids research, , Volume: 40, Issue:19, 2012
Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research.PloS one, , Volume: 7, Issue:7, 2012
SF-6 attenuates 6-hydroxydopamine-induced neurotoxicity: an in vitro and in vivo investigation in experimental models of Parkinson's disease.Journal of ethnopharmacology, , Sep-28, Volume: 143, Issue:2, 2012
Evaluation of the role of SNCA variants in survival without neurological disease.PloS one, , Volume: 7, Issue:8, 2012
Recommendations to standardize preanalytical confounding factors in Alzheimer's and Parkinson's disease cerebrospinal fluid biomarkers: an update.Biomarkers in medicine, , Volume: 6, Issue:4, 2012
Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders.Archives of neurology, , Volume: 69, Issue:11, 2012
Spinal cord lesions in sporadic Parkinson's disease.Acta neuropathologica, , Volume: 124, Issue:5, 2012
Lysosome-dependent pathways as a unifying theme in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Sep-15, Volume: 27, Issue:11, 2012
Parkinson's disease is not associated with gastrointestinal myenteric ganglion neuron loss.Acta neuropathologica, , Volume: 124, Issue:5, 2012
Dysfunction of two lysosome degradation pathways of α-synuclein in Parkinson's disease: potential therapeutic targets?Neuroscience bulletin, , Volume: 28, Issue:5, 2012
Correlation between protective immunity to α-synuclein aggregates, oxidative stress and inflammation.Neuroimmunomodulation, , Volume: 19, Issue:6, 2012
α-Synuclein disrupts stress signaling by inhibiting polo-like kinase Cdc5/Plk2.Proceedings of the National Academy of Sciences of the United States of America, , Oct-02, Volume: 109, Issue:40, 2012
Prenatal exposure to methanol as a dopamine system sensitization model in C57BL/6J mice.Life sciences, , Nov-02, Volume: 91, Issue:19-20, 2012
Alternative α-synuclein transcript usage as a convergent mechanism in Parkinson's disease pathology.Nature communications, , Volume: 3, 2012
Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H β-synuclein.Molecular brain, , Sep-26, Volume: 5, 2012
Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease.Molecular neurodegeneration, , Sep-28, Volume: 7, 2012
The role of alpha-synuclein in melanin synthesis in melanoma and dopaminergic neuronal cells.PloS one, , Volume: 7, Issue:9, 2012
Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains.Annals of neurology, , Volume: 72, Issue:3, 2012
Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue.Molecular brain, , Oct-06, Volume: 5, 2012
Physical training exerts neuroprotective effects in the regulation of neurochemical factors in an animal model of Parkinson's disease.Neuroscience, , Dec-27, Volume: 227, 2012
NADPH oxidase 1 mediates α-synucleinopathy in Parkinson's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Oct-17, Volume: 32, Issue:42, 2012
Radiating amyloid fibril formation on the surface of lipid membranes through unit-assembly of oligomeric species of α-synuclein.PloS one, , Volume: 7, Issue:10, 2012
An intrinsically disordered region of the acetyltransferase p300 with similarity to prion-like domains plays a role in aggregation.PloS one, , Volume: 7, Issue:11, 2012
Development and characterization of a new Parkinson's disease model resulting from impaired autophagy.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-14, Volume: 32, Issue:46, 2012
[Aiming to develop biochemical biomarkers for Parkinson's disease and related disorders].Rinsho shinkeigaku = Clinical neurology, , Volume: 52, Issue:11, 2012
Accumulation of α-synuclein triggered by presynaptic dysfunction.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-28, Volume: 32, Issue:48, 2012
Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate.Scientific reports, , Volume: 2, 2012
Molecular simulations of the fluctuating conformational dynamics of intrinsically disordered proteins.Physical review. E, Statistical, nonlinear, and soft matter physics, , Volume: 86, Issue:4 Pt 1, 2012
Astrocyte-specific overexpression of Nrf2 delays motor pathology and synuclein aggregation throughout the CNS in the alpha-synuclein mutant (A53T) mouse model.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Dec-05, Volume: 32, Issue:49, 2012
α-Synuclein aggregation and modulating factors.Sub-cellular biochemistry, , Volume: 65, 2012
Parkinson's disease.Sub-cellular biochemistry, , Volume: 65, 2012
[The Parkinson puzzle].Orvosi hetilap, , Dec-30, Volume: 153, Issue:52, 2012
Changes in selenoprotein P in substantia nigra and putamen in Parkinson's disease.Journal of Parkinson's disease, , Volume: 2, Issue:2, 2012
Covalent α-synuclein dimers: chemico-physical and aggregation properties.PloS one, , Volume: 7, Issue:12, 2012
α-Synuclein and anti-α-synuclein antibodies in Parkinson's disease, atypical Parkinson syndromes, REM sleep behavior disorder, and healthy controls.PloS one, , Volume: 7, Issue:12, 2012
Αlpha-synuclein levels in blood plasma from LRRK2 mutation carriers.PloS one, , Volume: 7, Issue:12, 2012
Changes in sphingomyelin level affect alpha-synuclein and ABCA5 expression.Journal of Parkinson's disease, , Volume: 2, Issue:1, 2012
Loss of functional alpha-synuclein: a toxic event in Parkinson's disease?Journal of Parkinson's disease, , Volume: 2, Issue:4, 2012
[Analysis of the rs12720208 single-nucleotide polymorphism of the FGF20 gene in Russian patients with sporadic Parkinson's disease].Genetika, , Volume: 48, Issue:12, 2012
CSF α-synuclein does not differentiate between parkinsonian disorders.Neurobiology of aging, , Volume: 33, Issue:2, 2012
Pale neurites, premature α-synuclein aggregates with centripetal extension from axon collaterals.Brain pathology (Zurich, Switzerland), , Volume: 22, Issue:1, 2012
Successful subthalamic stimulation in genetic Parkinson's disease caused by duplication of the α-synuclein gene.Journal of neurology, , Volume: 259, Issue:1, 2012
Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 27, Issue:6, 2012
Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 22, Issue:1, 2012
Biophysics of α-synuclein membrane interactions.Biochimica et biophysica acta, , Volume: 1818, Issue:2, 2012
Involvement of the spinal cord in Parkinson's disease.The International journal of neuroscience, , Volume: 122, Issue:1, 2012
Mitochondrial dysfunction in genetic animal models of Parkinson's disease.Antioxidants & redox signaling, , May-01, Volume: 16, Issue:9, 2012
Post mortem cerebrospinal fluid α-synuclein levels are raised in multiple system atrophy and distinguish this from the other α-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies.Neurobiology of disease, , Volume: 45, Issue:1, 2012
α-Synuclein in the olfactory system of a mouse model of Parkinson's disease: correlation with olfactory projections.Brain structure & function, , Volume: 217, Issue:2, 2012
Α-synuclein neuropathology is controlled by nuclear hormone receptors and enhanced by docosahexaenoic acid in a mouse model for Parkinson's disease.Brain pathology (Zurich, Switzerland), , Volume: 22, Issue:3, 2012
A53T-alpha-synuclein-overexpression in the mouse nigrostriatal pathway leads to early increase of 14-3-3 epsilon and late increase of GFAP.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 119, Issue:3, 2012
Autonomic involvement in Parkinson's disease: pathology, pathophysiology, clinical features and possible peripheral biomarkers.Journal of the neurological sciences, , Feb-15, Volume: 313, Issue:1-2, 2012
DJ-1 and αSYN in LRRK2 CSF do not correlate with striatal dopaminergic function.Neurobiology of aging, , Volume: 33, Issue:4, 2012
Inclusion of a portion of the native SNCA 3'UTR reduces toxicity of human S129A SNCA on striatal-projecting dopamine neurons in rat substantia nigra.Developmental neurobiology, , Volume: 72, Issue:6, 2012
Α-synuclein misfolding and Parkinson's disease.Biochimica et biophysica acta, , Volume: 1822, Issue:2, 2012
A search for SNCA 3' UTR variants identified SNP rs356165 as a determinant of disease risk and onset age in Parkinson's disease.Journal of molecular neuroscience : MN, , Volume: 47, Issue:3, 2012
Neuropathology of sporadic Parkinson's disease: evaluation and changes of concepts.Movement disorders : official journal of the Movement Disorder Society, , Volume: 27, Issue:1, 2012
Phosphorylated α-synuclein immunoreactivity in the posterior pituitary lobe.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 32, Issue:4, 2012
Genetic and pathological links between Parkinson's disease and the lysosomal disorder Sanfilippo syndrome.Movement disorders : official journal of the Movement Disorder Society, , Volume: 27, Issue:2, 2012
SNCA and MAPT genes: Independent and joint effects in Parkinson disease in the Italian population.Parkinsonism & related disorders, , Volume: 18, Issue:3, 2012
Can Parkinson's disease pathology be propagated from one neuron to another?Progress in neurobiology, , Volume: 97, Issue:2, 2012
α-Synuclein modifies huntingtin aggregation in living cells.FEBS letters, , Jan-02, Volume: 586, Issue:1, 2012
Characterization of heparin-induced glyceraldehyde-3-phosphate dehydrogenase early amyloid-like oligomers and their implication in α-synuclein aggregation.The Journal of biological chemistry, , Jan-20, Volume: 287, Issue:4, 2012
Molecular pathogenesis of Parkinson's disease: update.Journal of neurology, neurosurgery, and psychiatry, , Volume: 83, Issue:4, 2012
α-Synuclein synaptic pathology and its implications in the development of novel therapeutic approaches to cure Parkinson's disease.Brain research, , Jan-13, Volume: 1432, 2012
First neuropathological description of a patient with Parkinson's disease and LRRK2 p.N1437H mutation.Parkinsonism & related disorders, , Volume: 18, Issue:4, 2012
Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression.Molecular and cellular neurosciences, , Volume: 49, Issue:2, 2012
Vaccination for Parkinson's disease.Parkinsonism & related disorders, , Volume: 18 Suppl 1, 2012
Misfolded α-synuclein and Toll-like receptors: therapeutic targets for Parkinson's disease.Parkinsonism & related disorders, , Volume: 18 Suppl 1, 2012
Synucleinopathies from bench to bedside.Parkinsonism & related disorders, , Volume: 18 Suppl 1, 2012
Patterns of α-synuclein pathology in incidental cases and clinical subtypes of Parkinson's disease.Parkinsonism & related disorders, , Volume: 18 Suppl 1, 2012
Molecular pathways in sporadic PD.Parkinsonism & related disorders, , Volume: 18 Suppl 1, 2012
α-Synuclein potentiates interleukin-1β-induced CXCL10 expression in human A172 astrocytoma cells.Neuroscience letters, , Jan-24, Volume: 507, Issue:2, 2012
Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons.Neurobiology of disease, , Volume: 45, Issue:3, 2012
Meta-analysis of genetic and environmental Parkinson's disease models reveals a common role of mitochondrial protection pathways.Neurobiology of disease, , Volume: 45, Issue:3, 2012
Synaptic protein alterations in Parkinson's disease.Molecular neurobiology, , Volume: 45, Issue:1, 2012
Peculiarities of copper binding to alpha-synuclein.Journal of biomolecular structure & dynamics, , Volume: 29, Issue:4, 2012
Curcumin-glucoside, a novel synthetic derivative of curcumin, inhibits α-synuclein oligomer formation: relevance to Parkinson's disease.Current pharmaceutical design, , Volume: 18, Issue:1, 2012
Fluoxetine rescues impaired hippocampal neurogenesis in a transgenic A53T synuclein mouse model.The European journal of neuroscience, , Volume: 35, Issue:1, 2012
Use of viral vectors to create animal models for Parkinson's disease.Neurobiology of disease, , Volume: 48, Issue:2, 2012
Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway.Molecular neurodegeneration, , Jan-09, Volume: 7, 2012
Reduced content of α-synuclein in peripheral blood leukocytes of patients with LRRK2-associated Parkinson's disease.Bulletin of experimental biology and medicine, , Volume: 150, Issue:6, 2011
[Neuropathology].Rinsho shinkeigaku = Clinical neurology, , Volume: 51, Issue:11, 2011
Mechanism of copper(II)-induced misfolding of Parkinson's disease protein.Scientific reports, , Volume: 1, 2011
Phosphorylation of α-Synuclein at Y125 and S129 alters its metal binding properties: implications for understanding the role of α-Synuclein in the pathogenesis of Parkinson's Disease and related disorders.ACS chemical neuroscience, , Nov-16, Volume: 2, Issue:11, 2011
Colonic neuropathology is independent of olfactory dysfunction in Parkinson's disease.Journal of Parkinson's disease, , Volume: 1, Issue:4, 2011
Rab1A over-expression prevents Golgi apparatus fragmentation and partially corrects motor deficits in an alpha-synuclein based rat model of Parkinson's disease.Journal of Parkinson's disease, , Volume: 1, Issue:4, 2011
Disentangling the relationship between lewy bodies and nigral neuronal loss in Parkinson's disease.Journal of Parkinson's disease, , Volume: 1, Issue:3, 2011
Interaction between α-synuclein and tau genotypes and the progression of Parkinson's disease.Journal of Parkinson's disease, , Volume: 1, Issue:3, 2011
Mouse models of cognitive deficits due to alpha-synuclein pathology.Journal of Parkinson's disease, , Volume: 1, Issue:3, 2011
Mitochondrial dysfunction in skin fibroblasts from a Parkinson's disease patient with an alpha-synuclein triplication.Journal of Parkinson's disease, , Volume: 1, Issue:2, 2011
Cardiovascular autonomic dysfunction in animal models of Parkinson's disease.Journal of Parkinson's disease, , Volume: 1, Issue:4, 2011
Incidental Lewy body disease: do some cases represent a preclinical stage of dementia with Lewy bodies?Neurobiology of aging, , Volume: 32, Issue:5, 2011
Phosphorylation of α-synuclein upregulates tyrosine hydroxylase activity in MN9D cells.Acta histochemica, , Volume: 113, Issue:1, 2011
Presence of tissue transglutaminase in granular endoplasmic reticulum is characteristic of melanized neurons in Parkinson's disease brain.Brain pathology (Zurich, Switzerland), , Volume: 21, Issue:2, 2011
α-synuclein aggregation reduces nigral myocyte enhancer factor-2D in idiopathic and experimental Parkinson's disease.Neurobiology of disease, , Volume: 41, Issue:1, 2011
Neuropathology of sporadic Parkinson disease before the appearance of parkinsonism: preclinical Parkinson disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 118, Issue:5, 2011
Postural instability/gait disturbance in Parkinson's disease has distinct subtypes: an exploratory analysis.Journal of neurology, neurosurgery, and psychiatry, , Volume: 82, Issue:5, 2011
Aberrant protein structure and diseases of the brain.Irish journal of medical science, , Volume: 180, Issue:1, 2011
Apoptosis in Parkinson's disease: is p53 the missing link between genetic and sporadic Parkinsonism?Cellular signalling, , Volume: 23, Issue:6, 2011
Synaptic dysfunction in genetic models of Parkinson's disease: a role for autophagy?Neurobiology of disease, , Volume: 43, Issue:1, 2011
CD3 in Lewy pathology: does the abnormal recall of neurodevelopmental processes underlie Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 118, Issue:1, 2011
Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21.Human molecular genetics, , Jan-15, Volume: 20, Issue:2, 2011
The effect of SNCA 3' region on the levels of SNCA-112 splicing variant.Neurogenetics, , Volume: 12, Issue:1, 2011
Lack of interaction of SNCA and MAPT genotypes in Parkinson's disease.European journal of neurology, , Volume: 18, Issue:3, 2011
Inducible dopaminergic glutathione depletion in an α-synuclein transgenic mouse model results in age-related olfactory dysfunction.Neuroscience, , Jan-13, Volume: 172, 2011
Replication of GWAS associations for GAK and MAPT in Parkinson's disease.Annals of human genetics, , Volume: 75, Issue:2, 2011
Hallucinations and REM sleep behaviour disorder in Parkinson's disease: dream imagery intrusions and other hypotheses.Consciousness and cognition, , Volume: 20, Issue:4, 2011
Segmental conformational disorder and dynamics in the intrinsically disordered protein α-synuclein and its chain length dependence.Journal of molecular biology, , Feb-04, Volume: 405, Issue:5, 2011
Raised calcium promotes α-synuclein aggregate formation.Molecular and cellular neurosciences, , Volume: 46, Issue:2, 2011
Towards elucidation of the role of ubiquitination in the pathogenesis of Parkinson's disease with semisynthetic ubiquitinated α-synuclein.Angewandte Chemie (International ed. in English), , Jan-10, Volume: 50, Issue:2, 2011
The Parkinson disease protein α-synuclein inhibits autophagy.Autophagy, , Volume: 7, Issue:4, 2011
SNCA, MAPT, and GSK3B in Parkinson disease: a gene-gene interaction study.European journal of neurology, , Volume: 18, Issue:6, 2011
Assays for α-synuclein aggregation.Methods (San Diego, Calif.), , Volume: 53, Issue:3, 2011
Induction of the unfolded protein response by α-synuclein in experimental models of Parkinson's disease.Journal of neurochemistry, , Volume: 116, Issue:4, 2011
A pilot trial of the microtubule-interacting peptide (NAP) in mice overexpressing alpha-synuclein shows improvement in motor function and reduction of alpha-synuclein inclusions.Molecular and cellular neurosciences, , Volume: 46, Issue:3, 2011
Caenorhabditis elegans as a model system for identifying effectors of α-synuclein misfolding and dopaminergic cell death associated with Parkinson's disease.Methods (San Diego, Calif.), , Volume: 53, Issue:3, 2011
The role of His-50 of α-synuclein in binding Cu(II): pH dependence, speciation, thermodynamics and structure.Metallomics : integrated biometal science, , Volume: 3, Issue:3, 2011
A new perspective in Parkinson's disease, chaperone-mediated autophagy.Parkinsonism & related disorders, , Volume: 17, Issue:4, 2011
Interaction of prolyl oligopeptidase with α-synuclein.CNS & neurological disorders drug targets, , Volume: 10, Issue:3, 2011
The role of the C-terminus of human α-synuclein: intra-disulfide bonds between the C-terminus and other regions stabilize non-fibrillar monomeric isomers.FEBS letters, , Feb-04, Volume: 585, Issue:3, 2011
Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism.Pharmacological research, , Volume: 63, Issue:5, 2011
α-Synuclein, leucine-rich repeat kinase-2, and manganese in the pathogenesis of Parkinson disease.Neurotoxicology, , Volume: 32, Issue:5, 2011
Immunoprotection against toxic biomarkers is retained during Parkinson's disease progression.Journal of neuroimmunology, , Volume: 233, Issue:1-2, 2011
Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease.Environmental health perspectives, , Volume: 119, Issue:6, 2011
α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells.The Journal of clinical investigation, , Volume: 121, Issue:2, 2011
Genome-wide association study confirms extant PD risk loci among the Dutch.European journal of human genetics : EJHG, , Volume: 19, Issue:6, 2011
Alpha-synuclein is a cellular ferrireductase.PloS one, , Jan-10, Volume: 6, Issue:1, 2011
Mutant A53T alpha-synuclein induces neuronal death by increasing mitochondrial autophagy.The Journal of biological chemistry, , Mar-25, Volume: 286, Issue:12, 2011
Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study.Human molecular genetics, , Apr-15, Volume: 20, Issue:8, 2011
Defects in very long chain fatty acid synthesis enhance alpha-synuclein toxicity in a yeast model of Parkinson's disease.PloS one, , Jan-11, Volume: 6, Issue:1, 2011
Decreased reuptake of dopamine in the dorsal striatum in the absence of α-synuclein.Brain research, , Mar-25, Volume: 1382, 2011
Copper(II) enhances membrane-bound α-synuclein helix formation.Metallomics : integrated biometal science, , Volume: 3, Issue:3, 2011
From GWAS to clinical utility in Parkinson's disease.Lancet (London, England), , Feb-19, Volume: 377, Issue:9766, 2011
Low-resolution structure of a vesicle disrupting α-synuclein oligomer that accumulates during fibrillation.Proceedings of the National Academy of Sciences of the United States of America, , Feb-22, Volume: 108, Issue:8, 2011
Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission.Neurobiology of disease, , Volume: 42, Issue:3, 2011
α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study.The Lancet. Neurology, , Volume: 10, Issue:3, 2011
Coordination features and affinity of the Cu²+ site in the α-synuclein protein of Parkinson's disease.Biochemistry, , Mar-22, Volume: 50, Issue:11, 2011
Redox activity of α-synuclein-Cu is silenced by Zn₇-metallothionein-3.Free radical biology & medicine, , Jun-01, Volume: 50, Issue:11, 2011
Role of matrix metalloproteinase 3-mediated alpha-synuclein cleavage in dopaminergic cell death.The Journal of biological chemistry, , Apr-22, Volume: 286, Issue:16, 2011
Specificity and kinetics of alpha-synuclein binding to model membranes determined with fluorescent excited state intramolecular proton transfer (ESIPT) probe.The Journal of biological chemistry, , Apr-15, Volume: 286, Issue:15, 2011
Residue-specific fluorescent probes of α-synuclein: detection of early events at the N- and C-termini during fibril assembly.Biochemistry, , Mar-29, Volume: 50, Issue:12, 2011
A microRNA embedded AAV α-synuclein gene silencing vector for dopaminergic neurons.Brain research, , Apr-22, Volume: 1386, 2011
Structures behind the amyloid aggregation of α-synuclein: an NMR based approach.Current protein & peptide science, , Volume: 12, Issue:3, 2011
Salivary α-synuclein and DJ-1: potential biomarkers for Parkinson's disease.Brain : a journal of neurology, , Volume: 134, Issue:Pt 7, 2011
Independent and joint effects of the MAPT and SNCA genes in Parkinson disease.Annals of neurology, , Volume: 69, Issue:5, 2011
Changes in the solubility and phosphorylation of α-synuclein over the course of Parkinson's disease.Acta neuropathologica, , Volume: 121, Issue:6, 2011
Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression.Annals of neurology, , Volume: 69, Issue:3, 2011
Progressive neurodegeneration or endogenous compensation in an animal model of Parkinson's disease produced by decreasing doses of alpha-synuclein.PloS one, , Mar-07, Volume: 6, Issue:3, 2011
Molecular chaperones and associated cellular clearance mechanisms against toxic protein conformers in Parkinson's disease.Neuro-degenerative diseases, , Volume: 8, Issue:6, 2011
Common variants in PARK loci and related genes and Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Feb-01, Volume: 26, Issue:2, 2011
SNCA locus duplication carriers: from genetics to Parkinson disease phenotypes.Human mutation, , Volume: 32, Issue:4, 2011
Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers.Experimental & molecular medicine, , Apr-30, Volume: 43, Issue:4, 2011
Replication of MAPT and SNCA, but not PARK16-18, as susceptibility genes for Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:5, 2011
Blockade of enzyme activity inhibits tissue transglutaminase-mediated transamidation of α-synuclein in a cellular model of Parkinson's disease.Neurochemistry international, , Volume: 58, Issue:7, 2011
Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds.FEBS letters, , Apr-20, Volume: 585, Issue:8, 2011
Tauopathic changes in the striatum of A53T α-synuclein mutant mouse model of Parkinson's disease.PloS one, , Mar-21, Volume: 6, Issue:3, 2011
Hyperphosphorylated Tau in an α-synuclein-overexpressing transgenic model of Parkinson's disease.The European journal of neuroscience, , Volume: 33, Issue:9, 2011
Increased expression of α-synuclein in aged human brain associated with neuromelanin accumulation.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 118, Issue:11, 2011
Cerebrospinal fluid Tau/α-synuclein ratio in Parkinson's disease and degenerative dementias.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:8, 2011
Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing.Annals of neurology, , Volume: 69, Issue:6, 2011
Direct interaction of α-synuclein and AKT regulates IGF-1 signaling: implication of Parkinson disease.Neuro-Signals, , Volume: 19, Issue:2, 2011
Striatal β-amyloid in dementia with Lewy bodies but not Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 118, Issue:5, 2011
Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α-synuclein.Journal of neuroscience research, , Volume: 89, Issue:7, 2011
Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein.The Journal of biological chemistry, , Jun-10, Volume: 286, Issue:23, 2011
Allostery in a disordered protein: oxidative modifications to α-synuclein act distally to regulate membrane binding.Journal of the American Chemical Society, , May-11, Volume: 133, Issue:18, 2011
The hexapeptide PGVTAV suppresses neurotoxicity of human α-synuclein aggregates.Biochemical and biophysical research communications, , May-06, Volume: 408, Issue:2, 2011
Converging environmental and genetic pathways in the pathogenesis of Parkinson's disease.Journal of the neurological sciences, , Jul-15, Volume: 306, Issue:1-2, 2011
α-Synuclein-induced tubule formation in lipid bilayers.The journal of physical chemistry. B, , May-19, Volume: 115, Issue:19, 2011
ASICs mediate the modulatory effect by paeoniflorin on α-synuclein autophagic degradation.Brain research, , Jun-17, Volume: 1396, 2011
Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applications.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:8, 2011
α-synuclein reactive antibodies as diagnostic biomarkers in blood sera of Parkinson's disease patients.PloS one, , Apr-25, Volume: 6, Issue:4, 2011
Parkinson's disease, cortical dysfunction, and alpha-synuclein.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:8, 2011
Increased dopaminergic cells and protein aggregates in the olfactory bulb of patients with neurodegenerative disorders.Acta neuropathologica, , Volume: 122, Issue:1, 2011
Expression of mutant alpha-synuclein modulates microglial phenotype in vitro.Journal of neuroinflammation, , May-09, Volume: 8, 2011
Parkinson disease: PD biomarkers-use of α-synuclein reaches new levels.Nature reviews. Neurology, , May-10, Volume: 7, Issue:6, 2011
Parkinson's disease with dementia, lewy-body disorders and alpha-synuclein: recent advances and a case report.Acta neurologica Taiwanica, , Volume: 20, Issue:1, 2011
A deadly spread: cellular mechanisms of α-synuclein transfer.Cell death and differentiation, , Volume: 18, Issue:9, 2011
Synphilin suppresses α-synuclein neurotoxicity in a Parkinson's disease Drosophila model.Genesis (New York, N.Y. : 2000), , Volume: 49, Issue:5, 2011
Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?Brain : a journal of neurology, , Volume: 134, Issue:Pt 5, 2011
α-Synuclein expression selectively affects tumorigenesis in mice modeling Parkinson's disease.PloS one, , Volume: 6, Issue:5, 2011
Stress, allostatic load, catecholamines, and other neurotransmitters in neurodegenerative diseases.Endocrine regulations, , Volume: 45, Issue:2, 2011
Proteasome inhibition induces α-synuclein SUMOylation and aggregate formation.Journal of the neurological sciences, , Aug-15, Volume: 307, Issue:1-2, 2011
Comparative analysis of different peptidyl-prolyl isomerases reveals FK506-binding protein 12 as the most potent enhancer of alpha-synuclein aggregation.The Journal of biological chemistry, , Jul-29, Volume: 286, Issue:30, 2011
Alpha-synuclein interacts with Glucocerebrosidase providing a molecular link between Parkinson and Gaucher diseases.The Journal of biological chemistry, , Aug-12, Volume: 286, Issue:32, 2011
Clinical features, with video documentation, of the original familial lewy body parkinsonism caused by α-synuclein triplication (Iowa kindred).Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:11, 2011
Neuroprotection of α-synuclein under acute and chronic rotenone and maneb treatment is abolished by its familial Parkinson's disease mutations A30P, A53T and E46K.Neurotoxicology, , Volume: 32, Issue:6, 2011
Enzyme-linked immunosorbent assays for α-synuclein with species and multimeric state specificities.Journal of neuroscience methods, , Aug-15, Volume: 199, Issue:2, 2011
Identification of novel α-synuclein isoforms in human brain tissue by using an online nanoLC-ESI-FTICR-MS method.Neurochemical research, , Volume: 36, Issue:11, 2011
Alpha- and beta-synuclein expression in Parkinson disease with and without dementia.Journal of the neurological sciences, , Nov-15, Volume: 310, Issue:1-2, 2011
Familial Parkinson disease mutations influence α-synuclein assembly.Neurobiology of disease, , Volume: 43, Issue:3, 2011
Pros and cons of a prion-like pathogenesis in Parkinson's disease.BMC neurology, , Jun-20, Volume: 11, 2011
Parkinson's disease-associated mutations in α-synuclein and UCH-L1 inhibit the unconventional secretion of UCH-L1.Neurochemistry international, , Volume: 59, Issue:2, 2011
Rho GTPase regulation of α-synuclein and VMAT2: implications for pathogenesis of Parkinson's disease.Molecular and cellular neurosciences, , Volume: 48, Issue:1, 2011
Disease-related and genetic correlates of psychotic symptoms in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:12, 2011
Structured regions of α-synuclein fibrils include the early-onset Parkinson's disease mutation sites.Journal of molecular biology, , Aug-26, Volume: 411, Issue:4, 2011
Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease.Disease models & mechanisms, , Volume: 4, Issue:5, 2011
Neuropathology underlying clinical variability in patients with synucleinopathies.Acta neuropathologica, , Volume: 122, Issue:2, 2011
The A53T mutation is key in defining the differences in the aggregation kinetics of human and mouse α-synuclein.Journal of the American Chemical Society, , Aug-31, Volume: 133, Issue:34, 2011
Can α-synuclein be targeted in novel therapies for Parkinson's disease?Expert review of neurotherapeutics, , Volume: 11, Issue:7, 2011
The curious case of phenocopies in families with genetic Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Aug-15, Volume: 26, Issue:10, 2011
A lysosomal lair for a pathogenic protein pair.Science translational medicine, , Jul-13, Volume: 3, Issue:91, 2011
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations.Cell, , Jul-22, Volume: 146, Issue:2, 2011
CSF α-synuclein, tau, and amyloid β in Parkinson's disease.The Lancet. Neurology, , Volume: 10, Issue:8, 2011
A BACwards glance at neurodegeneration: molecular insights into disease from LRRK2, SNCA and MAPT BAC-transgenic mice.Biochemical Society transactions, , Volume: 39, Issue:4, 2011
Toward the discovery of effective polycyclic inhibitors of alpha-synuclein amyloid assembly.The Journal of biological chemistry, , Sep-16, Volume: 286, Issue:37, 2011
Enhanced autophagy from chronic toxicity of iron and mutant A53T α-synuclein: implications for neuronal cell death in Parkinson disease.The Journal of biological chemistry, , Sep-23, Volume: 286, Issue:38, 2011
Gelsolin co-occurs with Lewy bodies in vivo and accelerates α-synuclein aggregation in vitro.Biochemical and biophysical research communications, , Aug-19, Volume: 412, Issue:1, 2011
Genetic variability in SNCA and Parkinson's disease.Neurogenetics, , Volume: 12, Issue:4, 2011
Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease.Neurology, , Aug-02, Volume: 77, Issue:5, 2011
Measurement of proteasomal dysfunction in cell models of dopaminergic degeneration.Methods in molecular biology (Clifton, N.J.), , Volume: 758, 2011
Do interactions between SNCA, MAPT, and LRRK2 genes contribute to Parkinson's disease susceptibility?Parkinsonism & related disorders, , Volume: 17, Issue:10, 2011
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein.The Journal of biological chemistry, , Sep-30, Volume: 286, Issue:39, 2011
Hsc70 protein interaction with soluble and fibrillar alpha-synuclein.The Journal of biological chemistry, , Oct-07, Volume: 286, Issue:40, 2011
Drug targets from genetics: α-synuclein.CNS & neurological disorders drug targets, , Sep-01, Volume: 10, Issue:6, 2011
Kinases as targets for Parkinson's disease: from genetics to therapy.CNS & neurological disorders drug targets, , Sep-01, Volume: 10, Issue:6, 2011
Proteostasis and movement disorders: Parkinson's disease and amyotrophic lateral sclerosis.Cold Spring Harbor perspectives in biology, , Oct-01, Volume: 3, Issue:10, 2011
Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus.Nature communications, , Aug-23, Volume: 2, 2011
Circadian dysfunction in a mouse model of Parkinson's disease.Experimental neurology, , Volume: 232, Issue:1, 2011
Phosphorylated α-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 25, Issue:12, 2011
Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells.The Journal of clinical investigation, , Volume: 121, Issue:9, 2011
The Parkinson's disease protein LRRK2 impairs proteasome substrate clearance without affecting proteasome catalytic activity.Cell death & disease, , Aug-25, Volume: 2, 2011
Initial neuropsychological impairments in patients with the E46K mutation of the α-synuclein gene (PARK 1).Journal of the neurological sciences, , Nov-15, Volume: 310, Issue:1-2, 2011
Parkinson's disease and α-synuclein expression.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:12, 2011
Macroautophagy and the proteasome are differently involved in the degradation of alpha-synuclein wild type and mutated A30P in an in vitro inducible model (PC12/TetOn).Neuroscience, , Nov-10, Volume: 195, 2011
Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis.The American journal of pathology, , Volume: 179, Issue:5, 2011
Modeling dopamine neuron degeneration in Caenorhabditis elegans.Methods in molecular biology (Clifton, N.J.), , Volume: 793, 2011
Anti-Parkinsonian effects of Bacopa monnieri: insights from transgenic and pharmacological Caenorhabditis elegans models of Parkinson's disease.Biochemical and biophysical research communications, , Oct-07, Volume: 413, Issue:4, 2011
Pre-fibrillar α-synuclein mutants cause Parkinson's disease-like non-motor symptoms in Drosophila.PloS one, , Volume: 6, Issue:9, 2011
Aggresome formation and segregation of inclusions influence toxicity of α-synuclein and synphilin-1 in yeast.Biochemical Society transactions, , Volume: 39, Issue:5, 2011
The oxysterol 27-hydroxycholesterol regulates α-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors--relevance to Parkinson's disease.Journal of neurochemistry, , Volume: 119, Issue:5, 2011
Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway.Proceedings of the National Academy of Sciences of the United States of America, , Oct-11, Volume: 108, Issue:41, 2011
Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:12, 2011
[The effect of small ubiquitin-like modifier-1 modification on the formation of Lewy body-like inclusions in cytoplasm and apoptosis of HEK293 cell induced by overexpression and mutation of alpha-synuclein].Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, , Volume: 28, Issue:5, 2011
The yin and yang of amyloid: insights from α-synuclein and repeat domain of Pmel17.Physical chemistry chemical physics : PCCP, , Dec-07, Volume: 13, Issue:45, 2011
Dopamine and α-synuclein dysfunction in Smad3 null mice.Molecular neurodegeneration, , Oct-13, Volume: 6, 2011
Convergence of miRNA expression profiling, α-synuclein interacton and GWAS in Parkinson's disease.PloS one, , Volume: 6, Issue:10, 2011
α-synuclein promotes neuroprotection through NF-κB-mediated transcriptional regulation of protein kinase Cδ.Science signaling, , Oct-18, Volume: 4, Issue:195, 2011
Pathological roles of α-synuclein in neurological disorders.The Lancet. Neurology, , Volume: 10, Issue:11, 2011
Identification of bilateral changes in TID1 expression in the 6-OHDA rat model of Parkinson's disease.PloS one, , Volume: 6, Issue:10, 2011
Genetic variants of α-synuclein are not associated with essential tremor.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:14, 2011
Identification of allele-specific RNAi effectors targeting genetic forms of Parkinson's disease.PloS one, , Volume: 6, Issue:10, 2011
Dynamic modeling of α-synuclein aggregation in dopaminergic neuronal system indicates points of neuroprotective intervention: experimental validation with implications for Parkinson's therapy.Neuroscience, , Dec-29, Volume: 199, 2011
Pathological looping in the synucleinopathies: investigating the link between Parkinson's disease and Gaucher disease.Disease models & mechanisms, , Volume: 4, Issue:6, 2011
Distinct hydration properties of wild-type and familial point mutant A53T of α-synuclein associated with Parkinson's disease.Biophysical journal, , Nov-02, Volume: 101, Issue:9, 2011
Caenorhabditis elegans as an experimental tool for the study of complex neurological diseases: Parkinson's disease, Alzheimer's disease and autism spectrum disorder.Invertebrate neuroscience : IN, , Volume: 11, Issue:2, 2011
Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes.Bioorganic & medicinal chemistry, , Dec-15, Volume: 19, Issue:24, 2011
Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-16, Volume: 31, Issue:46, 2011
SNCA triplication Parkinson's patient's iPSC-derived DA neurons accumulate α-synuclein and are susceptible to oxidative stress.PloS one, , Volume: 6, Issue:11, 2011
The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation.Journal of neuroinflammation, , Nov-28, Volume: 8, 2011
Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease.PloS one, , Volume: 6, Issue:12, 2011
[Pathologic substrate of synucleinopathies. Introduction].Revista espanola de geriatria y gerontologia, , Volume: 46 Suppl 1, 2011
[Role of genetics in the etiology of synucleinopathies].Revista espanola de geriatria y gerontologia, , Volume: 46 Suppl 1, 2011
Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein alpha-synuclein as revealed by ion mobility mass spectrometry.Chembiochem : a European journal of chemical biology, , Dec-16, Volume: 12, Issue:18, 2011
Tau reduction does not prevent motor deficits in two mouse models of Parkinson's disease.PloS one, , Volume: 6, Issue:12, 2011
A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death.Neurobiology of aging, , Volume: 31, Issue:1, 2010
Synergistic anti-Parkinsonism activity of high doses of B vitamins in a chronic cellular model.Neurobiology of aging, , Volume: 31, Issue:4, 2010
Lymphomonocyte alpha-synuclein levels in aging and in Parkinson disease.Neurobiology of aging, , Volume: 31, Issue:5, 2010
Selective noradrenergic vulnerability in α-synuclein transgenic mice.Neurobiology of aging, , Volume: 31, Issue:12, 2010
Mitochondrial trafficking of APP and alpha synuclein: Relevance to mitochondrial dysfunction in Alzheimer's and Parkinson's diseases.Biochimica et biophysica acta, , Volume: 1802, Issue:1, 2010
Genome-wide microarray analysis of the differential neuroprotective effects of antioxidants in neuroblastoma cells overexpressing the familial Parkinson's disease alpha-synuclein A53T mutation.Neurochemical research, , Volume: 35, Issue:1, 2010
A comparative study of LRRK2, PINK1 and genetically undefined familial Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry, , Volume: 81, Issue:4, 2010
Are genetic and sporadic Parkinson's disease patients equally susceptible to develop dementia?Journal of the neurological sciences, , Feb-15, Volume: 289, Issue:1-2, 2010
Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein: mechanistic insights and pathological implication.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 24, Issue:1, 2010
Structure and function of the molecular chaperone Hsp104 from yeast.Biopolymers, , Volume: 93, Issue:3, 2010
Hsp70 molecular chaperones and Parkinson's disease.Biopolymers, , Volume: 93, Issue:3, 2010
Establishment of stably transfected rat neuronal cell lines expressing alpha-synuclein GFP fusion proteins.Journal of molecular neuroscience : MN, , Volume: 41, Issue:1, 2010
VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease.Neurobiology of disease, , Volume: 37, Issue:2, 2010
G protein-coupled receptor kinase 5, overexpressed in the alpha-synuclein up-regulation model of Parkinson's disease, regulates bcl-2 expression.Brain research, , Jan-11, Volume: 1307, 2010
Oxidants induce alternative splicing of alpha-synuclein: Implications for Parkinson's disease.Free radical biology & medicine, , Feb-01, Volume: 48, Issue:3, 2010
Recurrent systemic infections with Streptococcus pneumoniae do not aggravate the course of experimental neurodegenerative diseases.Journal of neuroscience research, , Volume: 88, Issue:5, 2010
Curcumin exposure induces expression of the Parkinson's disease-associated leucine-rich repeat kinase 2 (LRRK2) in rat mesencephalic cells.Neuroscience letters, , Jan-04, Volume: 468, Issue:2, 2010
Dopamine facilitates alpha-synuclein oligomerization in human neuroblastoma SH-SY5Y cells.Biochemical and biophysical research communications, , Jan-01, Volume: 391, Issue:1, 2010
Letter to the editor on "Threonine 53 in alpha-synuclein is conserved in long-living non-primate animals".Biochemical and biophysical research communications, , Jan-01, Volume: 391, Issue:1, 2010
Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation.Brain : a journal of neurology, , Volume: 133, Issue:Pt 1, 2010
Lovastatin ameliorates alpha-synuclein accumulation and oxidation in transgenic mouse models of alpha-synucleinopathies.Experimental neurology, , Volume: 221, Issue:2, 2010
Binding of alpha-synuclein with Fe(III) and with Fe(II) and biological implications of the resultant complexes.Journal of inorganic biochemistry, , Volume: 104, Issue:4, 2010
Analysis of exon dosage using MLPA in South African Parkinson's disease patients.Neurogenetics, , Volume: 11, Issue:3, 2010
Yeast unfolds the road map toward alpha-synuclein-induced cell death.Cell death and differentiation, , Volume: 17, Issue:5, 2010
Clinical availability of skin biopsy in the diagnosis of Parkinson's disease.Neuroscience letters, , Jan-29, Volume: 469, Issue:3, 2010
Dysfunctional mitochondria uphold calpain activation: contribution to Parkinson's disease pathology.Neurobiology of disease, , Volume: 37, Issue:3, 2010
Pathogenesis of Parkinson's disease: emerging role of molecular chaperones.Trends in molecular medicine, , Volume: 16, Issue:1, 2010
DNA induced folding/fibrillation of alpha-synuclein: new insights in Parkinson's disease.Frontiers in bioscience (Landmark edition), , 01-01, Volume: 15, Issue:2, 2010
In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia.Neurology, , Jan-05, Volume: 74, Issue:1, 2010
Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopy.Biochemistry, , Feb-09, Volume: 49, Issue:5, 2010
Genetic basis of Parkinson disease.Neurosurgical focus, , Volume: 28, Issue:1, 2010
Ageing, neurodegeneration and Parkinson's disease.Age and ageing, , Volume: 39, Issue:2, 2010
DnaK/DnaJ/GrpE of Hsp70 system have differing effects on alpha-synuclein fibrillation involved in Parkinson's disease.International journal of biological macromolecules, , Mar-01, Volume: 46, Issue:2, 2010
Plasma alpha-synuclein in patients with Parkinson's disease with and without treatment.Movement disorders : official journal of the Movement Disorder Society, , Mar-15, Volume: 25, Issue:4, 2010
Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.Annals of human genetics, , Volume: 74, Issue:2, 2010
Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway.Cellular signalling, , Volume: 22, Issue:5, 2010
Neurodegenerative dementia and parkinsonism.The journal of nutrition, health & aging, , Volume: 14, Issue:1, 2010
TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in the brain of Parkinson's disease and dementia with Lewy bodies.Neurobiology of disease, , Volume: 38, Issue:2, 2010
DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity.Human molecular genetics, , Apr-15, Volume: 19, Issue:8, 2010
Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease.PloS one, , Jan-20, Volume: 5, Issue:1, 2010
Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes.Human molecular genetics, , May-01, Volume: 19, Issue:9, 2010
Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153.The Journal of biological chemistry, , Apr-23, Volume: 285, Issue:17, 2010
Altered ion channel formation by the Parkinson's-disease-linked E46K mutant of alpha-synuclein is corrected by GM3 but not by GM1 gangliosides.Journal of molecular biology, , Mar-19, Volume: 397, Issue:1, 2010
In silico evidence for glutathione- and iron-related pathogeneses in Parkinson's disease.Journal of neuroscience methods, , Apr-30, Volume: 188, Issue:1, 2010
The progression of pathology in Parkinson's disease.Annals of the New York Academy of Sciences, , Volume: 1184, 2010
Accelerated formation of alpha-synuclein oligomers by concerted action of the 20S proteasome and familial Parkinson mutations.Journal of bioenergetics and biomembranes, , Volume: 42, Issue:1, 2010
Strategies to increase the reproducibility of protein fibrillization in plate reader assays.Analytical biochemistry, , May-15, Volume: 400, Issue:2, 2010
alpha-Synuclein at the synaptic gate.Neuron, , Jan-14, Volume: 65, Issue:1, 2010
Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis.Neuron, , Jan-14, Volume: 65, Issue:1, 2010
DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease.Brain : a journal of neurology, , Volume: 133, Issue:Pt 3, 2010
Pure autonomic failure: a restricted Lewy body synucleinopathy or early Parkinson disease?Neurology, , Feb-16, Volume: 74, Issue:7, 2010
Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-17, Volume: 30, Issue:7, 2010
Dysregulation of autophagy and Parkinson's disease: the MEF2D link.Apoptosis : an international journal on programmed cell death, , Volume: 15, Issue:11, 2010
Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model.Human molecular genetics, , Jun-01, Volume: 19, Issue:11, 2010
Evidence in favor of Braak staging of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 25 Suppl 1, 2010
Clues to how alpha-synuclein damages neurons in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 25 Suppl 1, 2010
The behavior of alpha-synuclein in neurons.Movement disorders : official journal of the Movement Disorder Society, , Volume: 25 Suppl 1, 2010
Clinical implications of gene discovery in Parkinson's disease and parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Volume: 25 Suppl 1, 2010
Protein degradation, aggregation, and misfolding.Movement disorders : official journal of the Movement Disorder Society, , Volume: 25 Suppl 1, 2010
Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Jun-15, Volume: 25, Issue:8, 2010
Lysosomal degradation of alpha-synuclein in vivo.The Journal of biological chemistry, , Apr-30, Volume: 285, Issue:18, 2010
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-03, Volume: 30, Issue:9, 2010
Distinct region-specific alpha-synuclein oligomers in A53T transgenic mice: implications for neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-03, Volume: 30, Issue:9, 2010
Oligomeric alpha-synuclein and its role in neuronal death.IUBMB life, , Volume: 62, Issue:5, 2010
The regulatory role of α-synuclein and parkin in neuronal cell apoptosis; possible implications for the pathogenesis of Parkinson's disease.Apoptosis : an international journal on programmed cell death, , Volume: 15, Issue:11, 2010
Two Parkinson's disease patients with alpha-synuclein gene duplication and rapid cognitive decline.Movement disorders : official journal of the Movement Disorder Society, , May-15, Volume: 25, Issue:7, 2010
Dopamine quinones interact with alpha-synuclein to form unstructured adducts.Biochemical and biophysical research communications, , Apr-02, Volume: 394, Issue:2, 2010
Alpha-synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: implications in Parkinson's disease.FEBS letters, , Apr-16, Volume: 584, Issue:8, 2010
Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease.Acta neuropathologica, , Volume: 119, Issue:6, 2010
Involvement of the cerebral cortex in Parkinson disease linked with G2019S LRRK2 mutation without cognitive impairment.Acta neuropathologica, , Volume: 120, Issue:2, 2010
Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders.Acta neuropathologica, , Volume: 119, Issue:6, 2010
The structure of dopamine induced alpha-synuclein oligomers.European biophysics journal : EBJ, , Volume: 39, Issue:10, 2010
Differential effects of wild-type and A53T mutant isoform of alpha-synuclein on the mitochondrial proteome of differentiated SH-SY5Y cells.Journal of proteome research, , May-07, Volume: 9, Issue:5, 2010
Alpha-synuclein overexpression increases dopamine toxicity in BE2-M17 cells.BMC neuroscience, , Mar-25, Volume: 11, 2010
Biomarkers: Parkinson disease with dementia and dementia with Lewy bodies.Parkinsonism & related disorders, , Volume: 16, Issue:5, 2010
Allelic imbalance of expression and epigenetic regulation within the alpha-synuclein wild-type and p.Ala53Thr alleles in Parkinson disease.Human mutation, , Volume: 31, Issue:6, 2010
Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo.The Journal of biological chemistry, , Jun-04, Volume: 285, Issue:23, 2010
The HSP70 molecular chaperone is not beneficial in a mouse model of alpha-synucleinopathy.PloS one, , Apr-02, Volume: 5, Issue:4, 2010
alpha-Synucleinopathy in the human olfactory system in Parkinson's disease: involvement of calcium-binding protein- and substance P-positive cells.Acta neuropathologica, , Volume: 119, Issue:6, 2010
Nitrated alpha-synuclein induces the loss of dopaminergic neurons in the substantia nigra of rats.PloS one, , Apr-08, Volume: 5, Issue:4, 2010
Alpha-synuclein nitration and autophagy response are induced in peripheral blood cells from patients with Parkinson disease.Neuroscience letters, , Jun-14, Volume: 477, Issue:1, 2010
Extracellular neurosin degrades α-synuclein in cultured cells.Neuroscience research, , Volume: 67, Issue:4, 2010
Astrocytic expression of Parkinson's disease-related A53T alpha-synuclein causes neurodegeneration in mice.Molecular brain, , Apr-21, Volume: 3, 2010
Mitochondrial pathobiology in Parkinson's disease and amyotrophic lateral sclerosis.Journal of Alzheimer's disease : JAD, , Volume: 20 Suppl 2, 2010
Combined R-alpha-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease.Journal of cellular and molecular medicine, , Volume: 14, Issue:1-2, 2010
Perivascular nerve fiber α-synuclein regulates contractility of mouse aorta: a link to autonomic dysfunction in Parkinson's disease.Neurochemistry international, , Volume: 56, Issue:8, 2010
Membrane interactions of oligomeric alpha-synuclein: potential role in Parkinson's disease.Current protein & peptide science, , Volume: 11, Issue:5, 2010
Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson's disease cell model.BMC neuroscience, , Apr-30, Volume: 11, 2010
Cardiac sympathetic denervation precedes nigrostriatal loss in the E46K mutation of the alpha-synuclein gene (SNCA).Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 20, Issue:4, 2010
Drosophila histone deacetylase 6 protects dopaminergic neurons against {alpha}-synuclein toxicity by promoting inclusion formation.Molecular biology of the cell, , Jul-01, Volume: 21, Issue:13, 2010
Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains.The Journal of neuroscience : the official journal of the Society for Neuroscience, , May-05, Volume: 30, Issue:18, 2010
Regulation of Weibel-Palade body exocytosis by alpha-synuclein in endothelial cells.The Journal of biological chemistry, , Jul-09, Volume: 285, Issue:28, 2010
Parkinson's disease-related protein, alpha-synuclein, in malignant melanoma.PloS one, , May-05, Volume: 5, Issue:5, 2010
Lack of replication of a previously reported association between polymorphism in the 3'UTR of the alpha-synuclein gene and Parkinson's disease in Chinese subjects.Neuroscience letters, , Jul-19, Volume: 479, Issue:1, 2010
α-Synuclein: membrane interactions and toxicity in Parkinson's disease.Annual review of cell and developmental biology, , Volume: 26, 2010
Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update.Human mutation, , Volume: 31, Issue:7, 2010
[GSK-3beta: a central kinase for neurodegenerative diseases?].Medecine sciences : M/S, , Volume: 26, Issue:5, 2010
SNP rs7684318 of the alpha-synuclein gene is associated with Parkinson's disease in the Han Chinese population.Brain research, , Jul-30, Volume: 1346, 2010
alpha-Synuclein- and MPTP-generated rodent models of Parkinson's disease and the study of extracellular striatal dopamine dynamics: a microdialysis approach.CNS & neurological disorders drug targets, , Volume: 9, Issue:4, 2010
The role of phosphorylation in synucleinopathies: focus on Parkinson's disease.CNS & neurological disorders drug targets, , Volume: 9, Issue:4, 2010
Engineered disulfide bonds restore chaperone-like function of DJ-1 mutants linked to familial Parkinson's disease.Biochemistry, , Jul-13, Volume: 49, Issue:27, 2010
Parkinson disease: Parkinson disease-moving beyond association.Nature reviews. Neurology, , Volume: 6, Issue:6, 2010
SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease.Brain : a journal of neurology, , Volume: 133, Issue:Pt 7, 2010
Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease.Neuroscience letters, , Aug-09, Volume: 480, Issue:1, 2010
Alteration of the alpha-synuclein folding landscape by a mutation related to Parkinson's disease.Angewandte Chemie (International ed. in English), , May-03, Volume: 49, Issue:20, 2010
Caspase-cleaved transactivation response DNA-binding protein 43 in Parkinson's disease and dementia with Lewy bodies.Neuro-degenerative diseases, , Volume: 7, Issue:4, 2010
The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia.Acta neuropathologica, , Volume: 120, Issue:2, 2010
Staging of alpha-synuclein in the olfactory bulb in a model of Parkinson's disease: cell types involved.Movement disorders : official journal of the Movement Disorder Society, , Aug-15, Volume: 25, Issue:11, 2010
Alpha-synuclein, lipids and Parkinson's disease.Progress in lipid research, , Volume: 49, Issue:4, 2010
The lipid-binding domain of wild type and mutant alpha-synuclein: compactness and interconversion between the broken and extended helix forms.The Journal of biological chemistry, , Sep-03, Volume: 285, Issue:36, 2010
85-year old man with Parkinson's disease accompanying dementia.Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 62, Issue:6, 2010
Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia.Experimental neurology, , Volume: 225, Issue:1, 2010
Neuroscience and heart-brain medicine: the year in review.Cleveland Clinic journal of medicine, , Volume: 77 Suppl 3, 2010
N(ɛ)-(carboxymethyl)lysine linkage to α-synuclein and involvement of advanced glycation end products in α-synuclein deposits in an MPTP-intoxicated mouse model.Biochimie, , Volume: 92, Issue:10, 2010
TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains.Human molecular genetics, , Oct-01, Volume: 19, Issue:19, 2010
Parkinson disease: Progress towards a molecular biomarker for Parkinson disease.Nature reviews. Neurology, , Volume: 6, Issue:7, 2010
Sensitive and specific detection of α-synuclein in human plasma.Journal of neuroscience research, , Volume: 88, Issue:12, 2010
α-Synuclein gene may interact with environmental factors in increasing risk of Parkinson's disease.Neuroepidemiology, , Volume: 35, Issue:3, 2010
REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century.Neurology, , Aug-10, Volume: 75, Issue:6, 2010
New insights into the role of mitochondrial dysfunction and protein aggregation in Parkinson's disease.Biochimica et biophysica acta, , Volume: 1802, Issue:11, 2010
Tau protein: relevance to Parkinson's disease.The international journal of biochemistry & cell biology, , Volume: 42, Issue:11, 2010
Neuroimaging for Lewy body disease: is the in vivo molecular imaging of α-synuclein neuropathology required and feasible?Brain research reviews, , Oct-05, Volume: 65, Issue:1, 2010
Unravelling the role of defective genes.Progress in brain research, , Volume: 183, 2010
The impact of genetic research on our understanding of Parkinson's disease.Progress in brain research, , Volume: 183, 2010
Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies.Progress in brain research, , Volume: 183, 2010
Chaperone-mediated autophagy markers in Parkinson disease brains.Archives of neurology, , Volume: 67, Issue:12, 2010
Analysis of GWAS-linked loci in Parkinson disease reaffirms PARK16 as a susceptibility locus.Neurology, , Aug-10, Volume: 75, Issue:6, 2010
Redox reactions of the α-synuclein-Cu(2+) complex and their effects on neuronal cell viability.Biochemistry, , Sep-21, Volume: 49, Issue:37, 2010
[Function study advances of Parkinson disease related genes].Yi chuan = Hereditas, , Volume: 32, Issue:8, 2010
Alpha-synuclein in alpha-helical conformation at air-water interface: implication of conformation and orientation changes during its accumulation/aggregation.Chemical communications (Cambridge, England), , Sep-28, Volume: 46, Issue:36, 2010
Impaired sense of smell and color discrimination in monogenic and idiopathic Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Nov-15, Volume: 25, Issue:15, 2010
Probing the micelle-bound aggregation-prone state of α-synuclein with (19)F NMR spectroscopy.Chembiochem : a European journal of chemical biology, , Sep-24, Volume: 11, Issue:14, 2010
{alpha}-Synuclein gene duplication impairs reward learning.Proceedings of the National Academy of Sciences of the United States of America, , Sep-07, Volume: 107, Issue:36, 2010
Secrets of the shaking palsy.Nature, , Aug-26, Volume: 466, Issue:7310, 2010
Amyloid formation and disaggregation of α-synuclein and its tandem repeat (α-TR).Biochemical and biophysical research communications, , Oct-01, Volume: 400, Issue:4, 2010
Oral N-acetyl-cysteine attenuates loss of dopaminergic terminals in alpha-synuclein overexpressing mice.PloS one, , Aug-23, Volume: 5, Issue:8, 2010
Clinical course of the first Asian family with Parkinsonism related to SNCA triplication.Movement disorders : official journal of the Movement Disorder Society, , Dec-15, Volume: 25, Issue:16, 2010
Brain stem pathology in Parkinson's disease: an evaluation of the Braak staging model.Movement disorders : official journal of the Movement Disorder Society, , Nov-15, Volume: 25, Issue:15, 2010
Being too inclusive about synuclein inclusions.Nature medicine, , Volume: 16, Issue:9, 2010
Human beta-synuclein rendered fibrillogenic by designed mutations.The Journal of biological chemistry, , Dec-03, Volume: 285, Issue:49, 2010
Polyamine pathway contributes to the pathogenesis of Parkinson disease.Proceedings of the National Academy of Sciences of the United States of America, , Sep-28, Volume: 107, Issue:39, 2010
Glucocerebrosidase is present in α-synuclein inclusions in Lewy body disorders.Acta neuropathologica, , Volume: 120, Issue:5, 2010
Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.The EMBO journal, , Oct-20, Volume: 29, Issue:20, 2010
Stable alpha-synuclein oligomers strongly inhibit chaperone activity of the Hsp70 system by weak interactions with J-domain co-chaperones.The Journal of biological chemistry, , Dec-03, Volume: 285, Issue:49, 2010
Distribution of cerebral amyloid deposition and its relevance to clinical phenotype in Lewy body dementia.Neuroscience letters, , Dec-03, Volume: 486, Issue:1, 2010
α-Synuclein impairs macroautophagy: implications for Parkinson's disease.The Journal of cell biology, , Sep-20, Volume: 190, Issue:6, 2010
Mitochondrial α-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo.Neuroscience letters, , Dec-17, Volume: 486, Issue:3, 2010
Genetic mouse models of Parkinson's disease The state of the art.Progress in brain research, , Volume: 184, 2010
Viral vector-mediated overexpression of α-synuclein as a progressive model of Parkinson's disease.Progress in brain research, , Volume: 184, 2010
Effects of pH and temperature on the structural and thermodynamic character of alpha-syn12 peptide in aqueous solution.Journal of biomolecular structure & dynamics, , Volume: 28, Issue:3, 2010
Amyloid imaging of Lewy body-associated disorders.Movement disorders : official journal of the Movement Disorder Society, , Nov-15, Volume: 25, Issue:15, 2010
Effects of curvature and composition on α-synuclein binding to lipid vesicles.Biophysical journal, , Oct-06, Volume: 99, Issue:7, 2010
PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease.Science translational medicine, , Oct-06, Volume: 2, Issue:52, 2010
The genetics of Parkinson disease.Journal of geriatric psychiatry and neurology, , Volume: 23, Issue:4, 2010
Problems associated with fluid biomarkers for Parkinson's disease.Biomarkers in medicine, , Volume: 4, Issue:5, 2010
Quantification of α-synuclein in cerebrospinal fluid as a biomarker candidate: review of the literature and considerations for future studies.Biomarkers in medicine, , Volume: 4, Issue:5, 2010
Biomarkers in Parkinson's disease: a funder's perspective.Biomarkers in medicine, , Volume: 4, Issue:5, 2010
Identification of a helical intermediate in trifluoroethanol-induced alpha-synuclein aggregation.Proceedings of the National Academy of Sciences of the United States of America, , Nov-02, Volume: 107, Issue:44, 2010
Genetic analysis of pathways to Parkinson disease.Neuron, , Oct-21, Volume: 68, Issue:2, 2010
Phosphorylated alpha-synuclein at Ser-129 is targeted to the proteasome pathway in a ubiquitin-independent manner.The Journal of biological chemistry, , Dec-24, Volume: 285, Issue:52, 2010
α-Synuclein and dopamine at the crossroads of Parkinson's disease.Trends in neurosciences, , Volume: 33, Issue:12, 2010
CSF α-synuclein as a diagnostic biomarker for Parkinson disease and related dementias.Neurology, , Nov-16, Volume: 75, Issue:20, 2010
Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease.Neurology, , Nov-16, Volume: 75, Issue:20, 2010
Bioinorganic chemistry of Parkinson's disease: structural determinants for the copper-mediated amyloid formation of alpha-synuclein.Inorganic chemistry, , Nov-15, Volume: 49, Issue:22, 2010
αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction.Proceedings of the National Academy of Sciences of the United States of America, , Nov-09, Volume: 107, Issue:45, 2010
Proteomic analysis of dopamine and α-synuclein interplay in a cellular model of Parkinson's disease pathogenesis.The FEBS journal, , Volume: 277, Issue:23, 2010
A photoelectrochemical immunosensor based on Au-doped TiO2 nanotube arrays for the detection of α-synuclein.Chemistry (Weinheim an der Bergstrasse, Germany), , Dec-27, Volume: 16, Issue:48, 2010
Synergistic effects of environmental risk factors and gene mutations in Parkinson's disease accelerate age-related neurodegeneration.Journal of neurochemistry, , Volume: 115, Issue:6, 2010
Single molecule characterization of α-synuclein in aggregation-prone states.Biophysical journal, , Nov-03, Volume: 99, Issue:9, 2010
Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and Parkinson's disease-linked mutants.PloS one, , Oct-26, Volume: 5, Issue:10, 2010
SNCA variant associated with Parkinson disease and plasma alpha-synuclein level.Archives of neurology, , Volume: 67, Issue:11, 2010
Inhibiting α-synuclein oligomerization by stable cell-penetrating β-synuclein fragments recovers phenotype of Parkinson's disease model flies.PloS one, , Nov-10, Volume: 5, Issue:11, 2010
The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease.Nature reviews. Neuroscience, , Volume: 11, Issue:12, 2010
Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity.PloS one, , Nov-16, Volume: 5, Issue:11, 2010
CSF from Parkinson disease patients differentially affects cultured microglia and astrocytes.BMC neuroscience, , Nov-29, Volume: 11, 2010
CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease.PloS one, , Nov-24, Volume: 5, Issue:11, 2010
α-Synuclein and DJ-1 as potential biological fluid biomarkers for Parkinson's Disease.International journal of molecular sciences, , Oct-29, Volume: 11, Issue:11, 2010
Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease.Cell death & disease, , Volume: 1, 2010
[Progress in alpha-synuclein modifications and Parkinson's disease].Sheng li ke xue jin zhan [Progress in physiology], , Volume: 41, Issue:5, 2010
[Molecular genetics of familial Parkinson's disease].Rinsho shinkeigaku = Clinical neurology, , Volume: 50, Issue:11, 2010
[Gene for sporadic Parkinson's disease: common disease-common variants].Rinsho shinkeigaku = Clinical neurology, , Volume: 50, Issue:11, 2010
[Update on the pathophysiology of Parkinson' disease].Bulletin de l'Academie nationale de medecine, , Volume: 194, Issue:7, 2010
Parkin attenuates wild-type tau modification in the presence of beta-amyloid and alpha-synuclein.Journal of molecular neuroscience : MN, , Volume: 37, Issue:1, 2009
Dementia and visual hallucinations associated with limbic pathology in Parkinson's disease.Parkinsonism & related disorders, , Volume: 15, Issue:3, 2009
Early stages for Parkinson's development: alpha-synuclein misfolding and aggregation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 4, Issue:1, 2009
Oxidative stress involvement in alpha-synuclein oligomerization in Parkinson's disease cybrids.Antioxidants & redox signaling, , Volume: 11, Issue:3, 2009
A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders.Biochimica et biophysica acta, , Volume: 1792, Issue:7, 2009
Intralaminar nuclei of the thalamus in Lewy body diseases.Brain research bulletin, , Feb-16, Volume: 78, Issue:2-3, 2009
Alpha-synuclein multiplications with parkinsonism, dementia or progressive myoclonus?Parkinsonism & related disorders, , Volume: 15, Issue:5, 2009
Intrabody and Parkinson's disease.Biochimica et biophysica acta, , Volume: 1792, Issue:7, 2009
Cellular glutathione peroxidase in human brain: cellular distribution, and its potential role in the degradation of Lewy bodies in Parkinson's disease and dementia with Lewy bodies.Acta neuropathologica, , Volume: 117, Issue:1, 2009
Expression of Lewy body protein septin 4 in postmortem brain of Parkinson's disease and control subjects.Movement disorders : official journal of the Movement Disorder Society, , Jan-30, Volume: 24, Issue:2, 2009
Molecular mechanisms of alpha-synuclein neurodegeneration.Biochimica et biophysica acta, , Volume: 1792, Issue:7, 2009
Genotypic and phenotypic characteristics of Dutch patients with early onset Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Jan-30, Volume: 24, Issue:2, 2009
Dopamine complexes of iron in the etiology and pathogenesis of Parkinson's disease.Journal of inorganic biochemistry, , Volume: 103, Issue:1, 2009
Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders.Acta neuropathologica, , Volume: 117, Issue:2, 2009
Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders.Acta neuropathologica, , Volume: 117, Issue:2, 2009
Genomewide association study for susceptibility genes contributing to familial Parkinson disease.Human genetics, , Volume: 124, Issue:6, 2009
Clinical and pathological characteristics of patients with leucine-rich repeat kinase-2 mutations.Movement disorders : official journal of the Movement Disorder Society, , Jan-15, Volume: 24, Issue:1, 2009
Smoking and Parkinson's disease: does nicotine affect alpha-synuclein fibrillation?Biochimica et biophysica acta, , Volume: 1794, Issue:2, 2009
Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss?Neuroscience letters, , Feb-06, Volume: 450, Issue:3, 2009
Proteomic profiling of phosphoproteins and glycoproteins responsive to wild-type alpha-synuclein accumulation and aggregation.Biochimica et biophysica acta, , Volume: 1794, Issue:2, 2009
Can olfactory bulb biopsy be justified for the diagnosis of Parkinson's disease? Comments on "olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders".Acta neuropathologica, , Volume: 117, Issue:2, 2009
Genetic susceptibility in Parkinson's disease.Biochimica et biophysica acta, , Volume: 1792, Issue:7, 2009
Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease.Human molecular genetics, , Mar-01, Volume: 18, Issue:5, 2009
PAMAM dendrimers as potential agents against fibrillation of alpha-synuclein, a Parkinson's disease-related protein.Macromolecular bioscience, , Mar-10, Volume: 9, Issue:3, 2009
Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy.Science (New York, N.Y.), , Jan-02, Volume: 323, Issue:5910, 2009
Toxic effects of dopamine metabolism in Parkinson's disease.Parkinsonism & related disorders, , Volume: 15 Suppl 1, 2009
FGF20 and Parkinson's disease: no evidence of association or pathogenicity via alpha-synuclein expression.Movement disorders : official journal of the Movement Disorder Society, , Feb-15, Volume: 24, Issue:3, 2009
A pragmatic approach to biochemical systems theory applied to an alpha-synuclein-based model of Parkinson's disease.Journal of neuroscience methods, , Apr-15, Volume: 178, Issue:2, 2009
Granular assembly of alpha-synuclein leading to the accelerated amyloid fibril formation with shear stress.PloS one, , Volume: 4, Issue:1, 2009
Effects of UCH-L1 on alpha-synuclein over-expression mouse model of Parkinson's disease.Journal of neurochemistry, , Volume: 108, Issue:4, 2009
Detecting morphologically distinct oligomeric forms of alpha-synuclein.The Journal of biological chemistry, , Apr-24, Volume: 284, Issue:17, 2009
Induction of Parkinson disease-related proteins in motor neurons after transient spinal cord ischemia in rabbits.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 29, Issue:4, 2009
Molecular basis of Parkinson's disease.Neuroreport, , Jan-28, Volume: 20, Issue:2, 2009
Fluorescence microscopy and 3D image reconstruction of cytokine initiated disruption of the Parkinson disease associated proteins alpha-synuclein, tau and ubiquitin in cultured glial cells.Cytokine, , Volume: 45, Issue:3, 2009
Dissecting the mechanisms of tissue transglutaminase-induced cross-linking of alpha-synuclein: implications for the pathogenesis of Parkinson disease.The Journal of biological chemistry, , May-08, Volume: 284, Issue:19, 2009
Conversion of wild-type alpha-synuclein into mutant-type fibrils and its propagation in the presence of A30P mutant.The Journal of biological chemistry, , Mar-20, Volume: 284, Issue:12, 2009
Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps.Apoptosis : an international journal on programmed cell death, , Volume: 14, Issue:4, 2009
Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases.Biochimica et biophysica acta, , Volume: 1790, Issue:7, 2009
Parkinson's disease dementia and dementia with Lewy bodies: different aspects of one entity.International psychogeriatrics, , Volume: 21, Issue:2, 2009
Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity.Nature genetics, , Volume: 41, Issue:3, 2009
Evidence against a reliable staging system of alpha-synuclein pathology in Parkinson's disease.Neuropathology and applied neurobiology, , Volume: 35, Issue:1, 2009
Alpha-synuclein, alcohol use disorders, and Parkinson disease: a case-control study.Parkinsonism & related disorders, , Volume: 15, Issue:6, 2009
Familial Parkinsonism and early onset Parkinson's disease in a Brazilian movement disorders clinic: phenotypic characterization and frequency of SNCA, PRKN, PINK1, and LRRK2 mutations.Movement disorders : official journal of the Movement Disorder Society, , Apr-15, Volume: 24, Issue:5, 2009
Alpha-synuclein binds large unilamellar vesicles as an extended helix.Biochemistry, , Mar-24, Volume: 48, Issue:11, 2009
Genomic and proteomic biomarkers for Parkinson disease.Neurology, , Feb-17, Volume: 72, Issue:7 Suppl, 2009
Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease?Movement disorders : official journal of the Movement Disorder Society, , Apr-30, Volume: 24, Issue:6, 2009
Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-18, Volume: 29, Issue:7, 2009
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation.The Journal of clinical investigation, , Volume: 119, Issue:3, 2009
PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease.PloS one, , Volume: 4, Issue:2, 2009
Protein misfolding and aggregation in Parkinson's disease.Antioxidants & redox signaling, , Volume: 11, Issue:9, 2009
Formation of dopamine-mediated alpha-synuclein-soluble oligomers requires methionine oxidation.Free radical biology & medicine, , May-15, Volume: 46, Issue:10, 2009
Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , Mar-24, Volume: 106, Issue:12, 2009
The therapeutic potential of LRRK2 and alpha-synuclein in Parkinson's disease.Antioxidants & redox signaling, , Volume: 11, Issue:9, 2009
Nuclear and neuritic distribution of serine-129 phosphorylated alpha-synuclein in transgenic mice.Neuroscience, , Jun-02, Volume: 160, Issue:4, 2009
Anti-aggregation and fibril-destabilizing effects of sex hormones on alpha-synuclein fibrils in vitro.Experimental neurology, , Volume: 217, Issue:2, 2009
Parkinson's disease: from monogenic forms to genetic susceptibility factors.Human molecular genetics, , Apr-15, Volume: 18, Issue:R1, 2009
Nitrated {alpha}-synuclein-induced alterations in microglial immunity are regulated by CD4+ T cell subsets.Journal of immunology (Baltimore, Md. : 1950), , Apr-01, Volume: 182, Issue:7, 2009
Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease.Experimental neurology, , Volume: 218, Issue:2, 2009
Protein degradation in Parkinson disease revisited: it's complex.The Journal of clinical investigation, , Volume: 119, Issue:3, 2009
Unique copper-induced oligomers mediate alpha-synuclein toxicity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 23, Issue:8, 2009
Mixed lineage kinase 2 and hippocalcin are localized in Lewy bodies of Parkinson's disease.Journal of the neurological sciences, , Jun-15, Volume: 281, Issue:1-2, 2009
E46K Parkinson's-linked mutation enhances C-terminal-to-N-terminal contacts in alpha-synuclein.Journal of molecular biology, , May-22, Volume: 388, Issue:5, 2009
Regional differences in the severity of Lewy body pathology across the olfactory cortex.Neuroscience letters, , Apr-03, Volume: 453, Issue:2, 2009
Dopamine and the dopamine oxidation product 5,6-dihydroxylindole promote distinct on-pathway and off-pathway aggregation of alpha-synuclein in a pH-dependent manner.Journal of molecular biology, , Apr-03, Volume: 387, Issue:3, 2009
Alpha-Synuclein contributes to GSK-3beta-catalyzed Tau phosphorylation in Parkinson's disease models.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 23, Issue:9, 2009
Animal models of neurodegenerative diseases.Methods in molecular biology (Clifton, N.J.), , Volume: 549, 2009
[Pathological mechanisms of Parkinson's disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 61, Issue:4, 2009
[Causative gene and its associated gene for Parkinson disease and dystonia].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 61, Issue:4, 2009
Modulation effect of filamentous phage on alpha-synuclein aggregation.Biochemical and biophysical research communications, , Jun-12, Volume: 383, Issue:4, 2009
Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element.International journal of molecular sciences, , Volume: 10, Issue:3, 2009
Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction.Acta neuropathologica, , Volume: 117, Issue:6, 2009
Relative contribution of simple mutations vs. copy number variations in five Parkinson disease genes in the Belgian population.Human mutation, , Volume: 30, Issue:7, 2009
Contribution of endogenous G-protein-coupled receptor kinases to Ser129 phosphorylation of alpha-synuclein in HEK293 cells.Biochemical and biophysical research communications, , Jul-03, Volume: 384, Issue:3, 2009
Alpha-synuclein and familial Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Jun-15, Volume: 24, Issue:8, 2009
The genetics of Parkinson's syndromes: a critical review.Current opinion in genetics & development, , Volume: 19, Issue:3, 2009
Role of autophagy and proteasome degradation pathways in apoptosis of PC12 cells overexpressing human alpha-synuclein.Neuroscience letters, , May-01, Volume: 454, Issue:3, 2009
Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy.PloS one, , Volume: 4, Issue:5, 2009
Modulation of alpha-synuclein aggregation by dopamine: a review.Neurochemical research, , Volume: 34, Issue:10, 2009
The Parkinson disease-associated A30P mutation stabilizes alpha-synuclein against proteasomal degradation triggered by heme oxygenase-1 over-expression in human neuroblastoma cells.Journal of neurochemistry, , Volume: 110, Issue:2, 2009
On the mechanism of internalization of alpha-synuclein into microglia: roles of ganglioside GM1 and lipid raft.Journal of neurochemistry, , Volume: 110, Issue:1, 2009
The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson's disease.Journal of neurochemistry, , Volume: 110, Issue:1, 2009
Alpha-synuclein induces migration of BV-2 microglial cells by up-regulation of CD44 and MT1-MMP.Journal of neurochemistry, , Volume: 109, Issue:5, 2009
Exploiting a (13)C-labelled heparin analogue for in situ solid-state NMR investigations of peptide-glycan interactions within amyloid fibrils.Organic & biomolecular chemistry, , Jun-07, Volume: 7, Issue:11, 2009
Rescue of alpha-synuclein cytotoxicity by insulin-like growth factors.Biochemical and biophysical research communications, , Jul-31, Volume: 385, Issue:3, 2009
Charge neutralization and collapse of the C-terminal tail of alpha-synuclein at low pH.Protein science : a publication of the Protein Society, , Volume: 18, Issue:7, 2009
Reduction in QSART and vasoactive intestinal polypeptide expression in the skin of Parkinson's disease patients and its relation to dyshidrosis.Journal of cutaneous pathology, , Volume: 36, Issue:5, 2009
Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases.Journal of neurochemistry, , Volume: 109, Issue:5, 2009
Intrinsic disorder in proteins associated with neurodegenerative diseases.Frontiers in bioscience (Landmark edition), , 06-01, Volume: 14, Issue:14, 2009
Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration.PloS one, , Jun-03, Volume: 4, Issue:6, 2009
Relationship between alpha synuclein phosphorylation, proteasomal inhibition and cell death: relevance to Parkinson's disease pathogenesis.Journal of neurochemistry, , Volume: 110, Issue:3, 2009
Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human alpha-synuclein in transgenic mouse brain.Human molecular genetics, , Sep-01, Volume: 18, Issue:17, 2009
Aggregation-defective alpha-synuclein mutants inhibit the fibrillation of Parkinson's disease-linked alpha-synuclein variants.Biochemical and biophysical research communications, , Aug-14, Volume: 386, Issue:1, 2009
Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions.Neurobiology of disease, , Volume: 35, Issue:3, 2009
Clinical correlates of pathology in the claustrum in Parkinson's disease and dementia with Lewy bodies.Neuroscience letters, , Sep-11, Volume: 461, Issue:1, 2009
Parkinson's disease.Lancet (London, England), , Jun-13, Volume: 373, Issue:9680, 2009
Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease.Journal of neuropathology and experimental neurology, , Volume: 68, Issue:5, 2009
Leucine-rich repeat kinase 2 expression leads to aggresome formation that is not associated with alpha-synuclein inclusions.Journal of neuropathology and experimental neurology, , Volume: 68, Issue:7, 2009
Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein.Current protein & peptide science, , Volume: 10, Issue:5, 2009
Revelations and revolutions in the understanding of Parkinson's disease.Biochimica et biophysica acta, , Volume: 1792, Issue:7, 2009
A single nucleotide polymorphism in the 3'UTR of the SNCA gene encoding alpha-synuclein is a new potential susceptibility locus for Parkinson disease.Neuroscience letters, , Sep-18, Volume: 461, Issue:2, 2009
Binding of Cu(II) to human alpha-synucleins: comparison of wild type and the point mutations associated with the familial Parkinson's disease.The journal of physical chemistry. B, , Jul-16, Volume: 113, Issue:28, 2009
Structural characterization of alpha-synuclein in an aggregation prone state.Protein science : a publication of the Protein Society, , Volume: 18, Issue:9, 2009
High-resolution temperature-concentration diagram of alpha-synuclein conformation obtained from a single Förster resonance energy transfer image in a microfluidic device.Analytical chemistry, , Aug-15, Volume: 81, Issue:16, 2009
Etiology and pathogenesis of Parkinson disease.Neurologic clinics, , Volume: 27, Issue:3, 2009
Expanding the clinical phenotype of SNCA duplication carriers.Movement disorders : official journal of the Movement Disorder Society, , Sep-15, Volume: 24, Issue:12, 2009
Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications.Biochemical and biophysical research communications, , Sep-11, Volume: 387, Issue:1, 2009
[Genetics and present therapy options in Parkinson's disease: a review].Ideggyogyaszati szemle, , May-30, Volume: 62, Issue:5-6, 2009
Controlling aggregation propensity in A53T mutant of alpha-synuclein causing Parkinson's disease.Biochemical and biophysical research communications, , Sep-18, Volume: 387, Issue:2, 2009
Trends in the molecular pathogenesis and clinical therapeutics of common neurodegenerative disorders.International journal of molecular sciences, , Jun-03, Volume: 10, Issue:6, 2009
A triple-emission fluorescent probe reveals distinctive amyloid fibrillar polymorphism of wild-type alpha-synuclein and its familial Parkinson's disease mutants.Biochemistry, , Aug-11, Volume: 48, Issue:31, 2009
[Parkinson disease: genetics and neuronal death].Revue neurologique, , Volume: 165 Spec No 2, 2009
Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology.Neurobiology of disease, , Volume: 36, Issue:1, 2009
Parkinson disease: extranigral, multisystem, and {alpha}-synuclein "plus".Archives of neurology, , Volume: 66, Issue:7, 2009
Threonine 53 in alpha-synuclein is conserved in long-living non-primate animals.Biochemical and biophysical research communications, , Sep-25, Volume: 387, Issue:3, 2009
Repression of alpha-synuclein expression and toxicity by microRNA-7.Proceedings of the National Academy of Sciences of the United States of America, , Aug-04, Volume: 106, Issue:31, 2009
Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein.The American journal of pathology, , Volume: 175, Issue:2, 2009
Molecular pathogenesis of Parkinson disease: insights from genetic studies.Expert reviews in molecular medicine, , Jul-27, Volume: 11, 2009
On the mechanism of nonspecific inhibitors of protein aggregation: dissecting the interactions of alpha-synuclein with Congo red and lacmoid.Biochemistry, , Sep-08, Volume: 48, Issue:35, 2009
The ubiquitin ligase E6-AP promotes degradation of alpha-synuclein.Journal of neurochemistry, , Volume: 110, Issue:6, 2009
Clearance and phosphorylation of alpha-synuclein are inhibited in methionine sulfoxide reductase a null yeast cells.Journal of molecular neuroscience : MN, , Volume: 39, Issue:3, 2009
Is Parkinson's disease a prion disorder?Proceedings of the National Academy of Sciences of the United States of America, , Aug-04, Volume: 106, Issue:31, 2009
Interaction between alpha-synuclein and metal ions, still looking for a role in the pathogenesis of Parkinson's disease.Neuromolecular medicine, , Volume: 11, Issue:4, 2009
Methylation status and neurodegenerative markers in Parkinson disease.Clinical chemistry, , Volume: 55, Issue:10, 2009
Taking the chemical out of chemical genetics.Nature chemical biology, , Volume: 5, Issue:9, 2009
Preferentially increased nitration of alpha-synuclein at tyrosine-39 in a cellular oxidative model of Parkinson's disease.Analytical chemistry, , Sep-15, Volume: 81, Issue:18, 2009
[Dual effects of different concentrations of alpha-synuclein on the neurotoxicity of 6-hydroxydopamine in SH-SY5Y cells].Sheng li xue bao : [Acta physiologica Sinica], , Aug-25, Volume: 61, Issue:4, 2009
Formation and development of Lewy pathology: a critical update.Journal of neurology, , Volume: 256 Suppl 3, 2009
Biochemical and pathological correlates of cognitive and behavioural change in DLB/PDD.Journal of neurology, , Volume: 256 Suppl 3, 2009
Neurotoxic conversion of beta-synuclein: a novel approach to generate a transgenic mouse model of synucleinopathies?Journal of neurology, , Volume: 256 Suppl 3, 2009
Biological fluid biomarkers in neurodegenerative parkinsonism.Nature reviews. Neurology, , Volume: 5, Issue:10, 2009
Pathologic findings in retinal pigment epithelial cell implantation for Parkinson disease.Neurology, , Oct-06, Volume: 73, Issue:14, 2009
Dopamine-induced conformational changes in alpha-synuclein.PloS one, , Sep-04, Volume: 4, Issue:9, 2009
Relative preservation of thalamic centromedian nucleus in parkinsonian patients with dystonia.Movement disorders : official journal of the Movement Disorder Society, , Oct-30, Volume: 24, Issue:14, 2009
Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models.The EMBO journal, , Oct-21, Volume: 28, Issue:20, 2009
The molecular chaperone Hsp90 modulates intermediate steps of amyloid assembly of the Parkinson-related protein alpha-synuclein.The Journal of biological chemistry, , Nov-06, Volume: 284, Issue:45, 2009
Mechanism of amyloidogenesis: nucleation-dependent fibrillation versus double-concerted fibrillation.BMB reports, , Sep-30, Volume: 42, Issue:9, 2009
Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson's disease: an anatomical study.Acta neuropathologica, , Volume: 118, Issue:6, 2009
Parkin and PINK1 parkinsonism may represent nigral mitochondrial cytopathies distinct from Lewy body Parkinson's disease.Parkinsonism & related disorders, , Volume: 15, Issue:10, 2009
The morbid anatomy of dementia in Parkinson's disease.Acta neuropathologica, , Volume: 118, Issue:5, 2009
Concomitant progressive supranuclear palsy and multiple system atrophy: more than a simple twist of fate?Neuroscience letters, , Dec-31, Volume: 467, Issue:3, 2009
Dopamine D2 receptor knockout mice develop features of Parkinson disease.Annals of neurology, , Volume: 66, Issue:4, 2009
Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation.The Journal of clinical investigation, , Volume: 119, Issue:11, 2009
Modelling Parkinson's disease in Drosophila.Neuromolecular medicine, , Volume: 11, Issue:4, 2009
Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Oct-28, Volume: 29, Issue:43, 2009
Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip.The EMBO journal, , Dec-02, Volume: 28, Issue:23, 2009
Alpha-synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population.Movement disorders : official journal of the Movement Disorder Society, , Dec-15, Volume: 24, Issue:16, 2009
Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells.Proceedings of the National Academy of Sciences of the United States of America, , Nov-24, Volume: 106, Issue:47, 2009
Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria.The Lancet. Neurology, , Volume: 8, Issue:12, 2009
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.Nature genetics, , Volume: 41, Issue:12, 2009
Degeneration in different parkinsonian syndromes relates to astrocyte type and astrocyte protein expression.Journal of neuropathology and experimental neurology, , Volume: 68, Issue:10, 2009
Stereotaxical infusion of rotenone: a reliable rodent model for Parkinson's disease.PloS one, , Nov-18, Volume: 4, Issue:11, 2009
Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson's disease model.Rejuvenation research, , Volume: 12, Issue:5, 2009
From genes to proteins in mendelian Parkinson's disease: an overview.Anatomical record (Hoboken, N.J. : 2007), , Volume: 292, Issue:12, 2009
Creutzfeldt-jakob, Parkinson, lewy body dementia and Alzheimer diseases: from diagnosis to therapy.Central nervous system agents in medicinal chemistry, , Volume: 9, Issue:1, 2009
[Pathogenesis of sporadic Parkinson's disease: contribution of genetic and environmental risk factors].Rinsho shinkeigaku = Clinical neurology, , Volume: 49, Issue:11, 2009
[Pathophysiological process underlying Parkinson's disease: motor & non-motor symptoms].Rinsho shinkeigaku = Clinical neurology, , Volume: 49, Issue:11, 2009
alpha-synuclein and LRRK2: partners in crime.Neuron, , Dec-24, Volume: 64, Issue:6, 2009
Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.Neuron, , Dec-24, Volume: 64, Issue:6, 2009
Neuropathology of non-motor features of Parkinson disease.Parkinsonism & related disorders, , Volume: 15 Suppl 3, 2009
Dissecting the potential molecular mechanisms underlying alpha-synuclein cell-to-cell transfer in Parkinson's disease.Parkinsonism & related disorders, , Volume: 15 Suppl 3, 2009
Thalamic changes in Parkinson's disease.Parkinsonism & related disorders, , Volume: 15 Suppl 3, 2009
Age and Parkinson's disease-related neuronal death in the substantia nigra pars compacta.Journal of neural transmission. Supplementum, , Issue:73, 2009
Neurodegeneration in Parkinson's disease: genetics enlightens physiopathology.Journal of neural transmission. Supplementum, , Issue:73, 2009
[Sleep behavior disorder (RBD) in synucleionopaties].Glas. Srpska akademija nauka i umetnosti. Odeljenje medicinskih nauka, , Issue:50, 2009
Early alpha-synuclein lipoxidation in neocortex in Lewy body diseases.Neurobiology of aging, , Volume: 29, Issue:3, 2008
Mutant alpha-synuclein exacerbates age-related decrease of neurogenesis.Neurobiology of aging, , Volume: 29, Issue:6, 2008
Risk and protective haplotypes of the alpha-synuclein gene associated with Parkinson's disease differentially affect cognitive sequence learning.Genes, brain, and behavior, , Volume: 7, Issue:1, 2008
alpha-Synuclein gene duplication is present in sporadic Parkinson disease.Neurology, , Jan-01, Volume: 70, Issue:1, 2008
Human-based studies on alpha-synuclein deposition and relationship to Parkinson's disease symptoms.Experimental neurology, , Volume: 209, Issue:1, 2008
Localization of CKII beta subunits in Lewy bodies of Parkinson's disease.Journal of the neurological sciences, , Mar-15, Volume: 266, Issue:1-2, 2008
Dopamine receptor agonists reverse behavioral abnormalities of alpha-synuclein transgenic mouse, a new model of Parkinson's disease.Journal of neuroscience research, , Feb-15, Volume: 86, Issue:3, 2008
Alpha-synuclein promoter haplotypes and dementia in Parkinson's disease.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, , Apr-05, Volume: 147, Issue:3, 2008
Proteomics of Caenorhabditis elegans over-expressing human alpha-synuclein analyzed by fluorogenic derivatization-liquid chromatography/tandem mass spectrometry: identification of actin and several ribosomal proteins as negative markers at early ParkinsonBiomedical chromatography : BMC, , Volume: 22, Issue:3, 2008
In vivo alpha-synuclein overexpression in rodents: a useful model of Parkinson's disease?Experimental neurology, , Volume: 209, Issue:1, 2008
Parkinson's disease with Onuf's nucleus involvement mimicking multiple system atrophy.Journal of neurology, neurosurgery, and psychiatry, , Volume: 79, Issue:2, 2008
LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease.Neuropathology and applied neurobiology, , Volume: 34, Issue:3, 2008
Synphilin-1 isoforms in Parkinson's disease: regulation by phosphorylation and ubiquitylation.Cellular and molecular life sciences : CMLS, , Volume: 65, Issue:1, 2008
Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies.Acta neuropathologica, , Volume: 115, Issue:4, 2008
alpha-Synuclein pathology in the neostriatum in Parkinson's disease.Acta neuropathologica, , Volume: 115, Issue:4, 2008
Preventing effects of a novel anti-parkinsonian agent zonisamide on dopamine quinone formation.Neuroscience research, , Volume: 60, Issue:1, 2008
Autonomic dysfunction in RBD--what can it teach us about disease progression?Sleep medicine, , Volume: 9, Issue:5, 2008
Nitrated alpha-synuclein-activated microglial profiling for Parkinson's disease.Journal of neurochemistry, , Volume: 104, Issue:6, 2008
Dopamine differentially induces aggregation of A53T mutant and wild type alpha-synuclein: insights into the protein chemistry of Parkinson's disease.Biochemical and biophysical research communications, , Jan-25, Volume: 365, Issue:4, 2008
Glial reactions in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Mar-15, Volume: 23, Issue:4, 2008
Commentary to "Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease".Neurochemical research, , Volume: 33, Issue:6, 2008
The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease: a critical analysis of alpha-synuclein staging.Neuropathology and applied neurobiology, , Volume: 34, Issue:3, 2008
Characterization of the striatal 6-OHDA model of Parkinson's disease in wild type and alpha-synuclein-deleted mice.Experimental neurology, , Volume: 210, Issue:1, 2008
Complex I deficiency in Parkinson's disease frontal cortex.Brain research, , Jan-16, Volume: 1189, 2008
Oxidative-stress-induced apoptosis in PBLs of two patients with Parkinson disease secondary to alpha-synuclein mutation.Journal of the neurological sciences, , Apr-15, Volume: 267, Issue:1-2, 2008
Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death.Human molecular genetics, , Mar-15, Volume: 17, Issue:6, 2008
Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease.Brain : a journal of neurology, , Volume: 131, Issue:Pt 3, 2008
Alpha-synuclein selectively binds to anionic phospholipids embedded in liquid-disordered domains.Journal of molecular biology, , Feb-01, Volume: 375, Issue:5, 2008
Changes in interfacial properties of alpha-synuclein preceding its aggregation.The Analyst, , Volume: 133, Issue:1, 2008
Origins and effects of extracellular alpha-synuclein: implications in Parkinson's disease.Journal of molecular neuroscience : MN, , Volume: 34, Issue:1, 2008
Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 22, Issue:5, 2008
alpha-Synuclein gene duplications in sporadic Parkinson disease.Neurology, , Jan-01, Volume: 70, Issue:1, 2008
Noninvasive measurement of protein aggregation by mutant huntingtin fragments or alpha-synuclein in the lens.The Journal of biological chemistry, , Mar-07, Volume: 283, Issue:10, 2008
Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae.Molecular biology of the cell, , Volume: 19, Issue:3, 2008
Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy.The Journal of clinical investigation, , Volume: 118, Issue:2, 2008
The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease.Proceedings of the National Academy of Sciences of the United States of America, , Jan-15, Volume: 105, Issue:2, 2008
Is alpha-synuclein the culprit of the Parkinsonian neurodegeneration?Experimental neurology, , Volume: 209, Issue:1, 2008
Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jan-09, Volume: 28, Issue:2, 2008
Cortical alpha-synuclein load is associated with amyloid-beta plaque burden in a subset of Parkinson's disease patients.Acta neuropathologica, , Volume: 115, Issue:4, 2008
The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease.Brain : a journal of neurology, , Volume: 131, Issue:Pt 8, 2008
Transcriptional dysregulation in a transgenic model of Parkinson disease.Neurobiology of disease, , Volume: 29, Issue:3, 2008
alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease.The Journal of biological chemistry, , Mar-14, Volume: 283, Issue:11, 2008
Clinicopathologic study of a SNCA gene duplication patient with Parkinson disease and dementia.Neurology, , Jan-15, Volume: 70, Issue:3, 2008
Nitrated alpha-synuclein and microglial neuroregulatory activities.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 3, Issue:2, 2008
Exploring gene-environment interactions in Parkinson's disease.Human genetics, , Volume: 123, Issue:3, 2008
Analysis of Parkinson disease patients from Portugal for mutations in SNCA, PRKN, PINK1 and LRRK2.BMC neurology, , Jan-22, Volume: 8, 2008
Ubiquitination of alpha-synuclein and autophagy in Parkinson's disease.Autophagy, , Volume: 4, Issue:3, 2008
The effect of small molecules in modulating the chaperone activity of alphaB-crystallin against ordered and disordered protein aggregation.The FEBS journal, , Volume: 275, Issue:5, 2008
Striatal beta-amyloid deposition in Parkinson disease with dementia.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:2, 2008
Transgenic mice overexpressing tyrosine-to-cysteine mutant human alpha-synuclein: a progressive neurodegenerative model of diffuse Lewy body disease.The Journal of biological chemistry, , Apr-11, Volume: 283, Issue:15, 2008
Superoxide dismutase overexpression protects dopaminergic neurons in a Drosophila model of Parkinson's disease.Neurobiology of disease, , Volume: 30, Issue:1, 2008
Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain.The Journal of biological chemistry, , Apr-04, Volume: 283, Issue:14, 2008
Statins reduce neuronal alpha-synuclein aggregation in in vitro models of Parkinson's disease.Journal of neurochemistry, , Volume: 105, Issue:5, 2008
Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein.American journal of human genetics, , Volume: 82, Issue:2, 2008
Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers.The Journal of biological chemistry, , Apr-18, Volume: 283, Issue:16, 2008
The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease.Neuropathology and applied neurobiology, , Volume: 34, Issue:4, 2008
A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides.Nature neuroscience, , Volume: 11, Issue:3, 2008
Protein folding diseases and neurodegeneration: lessons learned from yeast.Biochimica et biophysica acta, , Volume: 1783, Issue:7, 2008
Aggregopathy in neurodegenerative diseases: mechanisms and therapeutic implication.Neuro-degenerative diseases, , Volume: 5, Issue:6, 2008
Genetic models of Parkinson's disease: mechanisms and therapies.SEB experimental biology series, , Volume: 60, 2008
Generation of a alpha-synuclein-based rat model of Parkinson's disease.Neurobiology of disease, , Volume: 30, Issue:1, 2008
Genetic factors involved in the pathogenesis of Parkinson's disease.Brain research reviews, , Volume: 58, Issue:2, 2008
Alpha-synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: lessons from viral transduction of knockout mice.Neuroscience letters, , Apr-11, Volume: 435, Issue:1, 2008
A not entirely benign procedure: progression of Parkinson's disease.Acta neuropathologica, , Volume: 115, Issue:4, 2008
Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies.Neuro-degenerative diseases, , Volume: 5, Issue:3-4, 2008
Characterization of fibrillation process of alpha-synuclein at the initial stage.Biochemical and biophysical research communications, , May-09, Volume: 369, Issue:3, 2008
Elevated alpha-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease.Nucleic acids research, , Volume: 36, Issue:7, 2008
Differential expression of alpha-synuclein, parkin, and synphilin-1 isoforms in Lewy body disease.Neurogenetics, , Volume: 9, Issue:3, 2008
Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies.Neuroscience, , Apr-09, Volume: 152, Issue:4, 2008
FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T.Journal of neurochemistry, , Volume: 106, Issue:1, 2008
New insights into the pathology of Parkinson's disease: does the peripheral autonomic system become central?European journal of neurology, , Volume: 15 Suppl 1, 2008
Quantitative proteomics of a presymptomatic A53T alpha-synuclein Drosophila model of Parkinson disease.Molecular & cellular proteomics : MCP, , Volume: 7, Issue:7, 2008
Selective detection, quantification, and subcellular location of alpha-synuclein aggregates with a protein aggregate filtration assay.BioTechniques, , Volume: 44, Issue:3, 2008
Patterns and stages of alpha-synucleinopathy: Relevance in a population-based cohort.Neurology, , Mar-25, Volume: 70, Issue:13, 2008
RNA interference mediated silencing of alpha-synuclein in MN9D cells and its effects on cell viability.Neuroscience bulletin, , Volume: 24, Issue:2, 2008
C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging.PLoS genetics, , Mar-21, Volume: 4, Issue:3, 2008
Detection of compounds that rescue Rab1-synuclein toxicity.Methods in enzymology, , Volume: 439, 2008
Formation of toxic oligomeric alpha-synuclein species in living cells.PloS one, , Apr-02, Volume: 3, Issue:4, 2008
DJ-1 modulates alpha-synuclein aggregation state in a cellular model of oxidative stress: relevance for Parkinson's disease and involvement of HSP70.PloS one, , Apr-02, Volume: 3, Issue:4, 2008
[Clinical and pathological study on early diagnosis of Parkinson's disease and dementia with Lewy bodies].Rinsho shinkeigaku = Clinical neurology, , Volume: 48, Issue:1, 2008
Clinical, neuropathological and genotypic variability in SNCA A53T familial Parkinson's disease. Variability in familial Parkinson's disease.Acta neuropathologica, , Volume: 116, Issue:1, 2008
The reaction of alpha-synuclein with tyrosinase: possible implications for Parkinson disease.The Journal of biological chemistry, , Jun-13, Volume: 283, Issue:24, 2008
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease.Nature medicine, , Volume: 14, Issue:5, 2008
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation.Nature medicine, , Volume: 14, Issue:5, 2008
Three-layered structure shared between Lewy bodies and lewy neurites-three-dimensional reconstruction of triple-labeled sections.Brain pathology (Zurich, Switzerland), , Volume: 18, Issue:3, 2008
Parkinson's disease. Signs of disease in fetal transplants.Science (New York, N.Y.), , Apr-11, Volume: 320, Issue:5873, 2008
Genetic association between alpha-synuclein and idiopathic Parkinson's disease.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, , Oct-05, Volume: 147B, Issue:7, 2008
Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: autonomic pathway implicated in Parkinson's disease?Neuroscience, , May-15, Volume: 153, Issue:3, 2008
Characterization of conformational and dynamic properties of natively unfolded human and mouse alpha-synuclein ensembles by NMR: implication for aggregation.Journal of molecular biology, , May-16, Volume: 378, Issue:5, 2008
Progress in the pathogenesis and genetics of Parkinson's disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences, , Jun-27, Volume: 363, Issue:1500, 2008
Multiparametric fluorescence detection of early stages in the amyloid protein aggregation of pyrene-labeled alpha-synuclein.Journal of molecular biology, , May-16, Volume: 378, Issue:5, 2008
Molecular determinants of the aggregation behavior of alpha- and beta-synuclein.Protein science : a publication of the Protein Society, , Volume: 17, Issue:5, 2008
Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification.Experimental cell research, , Jun-10, Volume: 314, Issue:10, 2008
Olfactory pathogenesis of idiopathic Parkinson disease revisited.Movement disorders : official journal of the Movement Disorder Society, , Jun-15, Volume: 23, Issue:8, 2008
Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Jun-15, Volume: 23, Issue:8, 2008
Controversies over the staging of alpha-synuclein pathology in Parkinson's disease.Acta neuropathologica, , Volume: 116, Issue:1, 2008
Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinson's disease.Glia, , Aug-15, Volume: 56, Issue:11, 2008
Striatal beta-amyloid deposition in Parkinson disease with dementia.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:5, 2008
Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:5, 2008
Methionine sulfoxide reductase A protects dopaminergic cells from Parkinson's disease-related insults.Free radical biology & medicine, , Aug-01, Volume: 45, Issue:3, 2008
Nurr1 transcriptionally regulates the expression of alpha-synuclein.Neuroreport, , May-28, Volume: 19, Issue:8, 2008
Abnormal colonic motility in mice overexpressing human wild-type alpha-synuclein.Neuroreport, , May-28, Volume: 19, Issue:8, 2008
Alpha-synuclein and Parkinson's disease: a proteomic view.Expert review of proteomics, , Volume: 5, Issue:2, 2008
Multiple alpha-synuclein gene polymorphisms are associated with Parkinson's disease in a Norwegian population.Acta neurologica Scandinavica, , Volume: 118, Issue:5, 2008
Non-autonomous cell death in Parkinson's disease.The Lancet. Neurology, , Volume: 7, Issue:6, 2008
Cu2+ binding modes of recombinant alpha-synuclein--insights from EPR spectroscopy.Journal of the American Chemical Society, , Jun-18, Volume: 130, Issue:24, 2008
Decreased activities of lysosomal acid alpha-D-galactosidase A in the leukocytes of sporadic Parkinson's disease.Journal of the neurological sciences, , Aug-15, Volume: 271, Issue:1-2, 2008
Cytokines disrupt intracellular patterns of Parkinson's disease-associated proteins alpha-synuclein, tau and ubiquitin in cultured glial cells.Brain research, , Jun-27, Volume: 1217, 2008
Tissue transglutaminase modulates alpha-synuclein oligomerization.Protein science : a publication of the Protein Society, , Volume: 17, Issue:8, 2008
Parkinson patient fibroblasts show increased alpha-synuclein expression.Experimental neurology, , Volume: 212, Issue:2, 2008
The alpha-synuclein burden hypothesis of Parkinson disease and its relationship to Alzheimer disease.Experimental neurology, , Volume: 212, Issue:2, 2008
Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease.Neuroscience letters, , Jul-11, Volume: 439, Issue:2, 2008
On the key role played by altered protein conformation in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 115, Issue:9, 2008
Solid-state NMR reveals structural differences between fibrils of wild-type and disease-related A53T mutant alpha-synuclein.Journal of molecular biology, , Jul-11, Volume: 380, Issue:3, 2008
Protein array analysis of oligomerization-induced changes in alpha-synuclein protein-protein interactions points to an interference with Cdc42 effector proteins.Neuroscience, , Jul-17, Volume: 154, Issue:4, 2008
Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy.The Journal of biological chemistry, , Aug-29, Volume: 283, Issue:35, 2008
Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders.Autoimmunity reviews, , Volume: 7, Issue:6, 2008
Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells.The Journal of biological chemistry, , Aug-29, Volume: 283, Issue:35, 2008
Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease.Human genetics, , Volume: 124, Issue:1, 2008
Genomic investigation of alpha-synuclein multiplication and parkinsonism.Annals of neurology, , Volume: 63, Issue:6, 2008
Fas-associated factor 1 and Parkinson's disease.Neurobiology of disease, , Volume: 31, Issue:3, 2008
Viral vectors, animal models and new therapies for Parkinson's disease.Parkinsonism & related disorders, , Volume: 14 Suppl 2, 2008
Cerebellar alpha-synuclein levels are decreased in Parkinson's disease and do not correlate with SNCA polymorphisms associated with disease in a Swedish material.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 22, Issue:10, 2008
Alpha-synuclein A30P point-mutation generates age-dependent nigrostriatal deficiency in mice.Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, , Volume: 59, Issue:2, 2008
The genetics and molecular biology of alpha-synuclein.Handbook of clinical neurology, , Volume: 89, 2008
Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson.Biochimica et biophysica acta, , Volume: 1783, Issue:10, 2008
Mechanism of alpha-synuclein oligomerization and membrane interaction: theoretical approach to unstructured proteins studies.Nanomedicine : nanotechnology, biology, and medicine, , Volume: 4, Issue:4, 2008
Nigral burden of alpha-synuclein correlates with striatal dopamine deficit.Movement disorders : official journal of the Movement Disorder Society, , Aug-15, Volume: 23, Issue:11, 2008
GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , Aug-05, Volume: 105, Issue:31, 2008
Immunological features of alpha-synuclein in Parkinson's disease.Journal of cellular and molecular medicine, , Volume: 12, Issue:5B, 2008
Genetics of iron regulation and the possible role of iron in Parkinson's disease.Neurobiology of disease, , Volume: 32, Issue:2, 2008
Mitochondrial alterations in Parkinson's disease: new clues.Journal of neurochemistry, , Volume: 107, Issue:2, 2008
Proteome response to the panneural expression of human wild-type alpha-synuclein: a Drosophila model of Parkinson's disease.Journal of proteome research, , Volume: 7, Issue:9, 2008
Controlling the mass action of alpha-synuclein in Parkinson's disease.Journal of neurochemistry, , Volume: 107, Issue:2, 2008
Impact of Tyr to Ala mutations on alpha-synuclein fibrillation and structural properties.Biochimica et biophysica acta, , Volume: 1782, Issue:10, 2008
Spermine binding to Parkinson's protein alpha-synuclein and its disease-related A30P and A53T mutants.The journal of physical chemistry. B, , Sep-04, Volume: 112, Issue:35, 2008
Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species.Biochemistry, , Sep-09, Volume: 47, Issue:36, 2008
Olfactory deficits in mice overexpressing human wildtype alpha-synuclein.The European journal of neuroscience, , Volume: 28, Issue:2, 2008
Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease.The Journal of clinical investigation, , Volume: 118, Issue:9, 2008
Analysis of PARK genes in a Korean cohort of early-onset Parkinson disease.Neurogenetics, , Volume: 9, Issue:4, 2008
alpha-synuclein degradation by autophagic pathways: a potential key to Parkinson's disease pathogenesis.Autophagy, , Volume: 4, Issue:7, 2008
[A new look at the corticostriatal-thalamocortical circuit in sporadic Parkinson's disease].Der Nervenarzt, , Volume: 79, Issue:12, 2008
Cardiac sympathetic denervation in Parkinson's disease linked to SNCA duplication.Acta neuropathologica, , Volume: 116, Issue:5, 2008
Insights into the effects of alpha-synuclein expression and proteasome inhibition on glutathione metabolism through a dynamic in silico model of Parkinson's disease: validation by cell culture data.Free radical biology & medicine, , Nov-01, Volume: 45, Issue:9, 2008
Research in motion: the enigma of Parkinson's disease pathology spread.Nature reviews. Neuroscience, , Volume: 9, Issue:10, 2008
Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases.PloS one, , Sep-04, Volume: 3, Issue:9, 2008
Novel suppressors of alpha-synuclein toxicity identified using yeast.Human molecular genetics, , Dec-01, Volume: 17, Issue:23, 2008
Structural characteristics of alpha-synuclein oligomers stabilized by the flavonoid baicalein.Journal of molecular biology, , Oct-31, Volume: 383, Issue:1, 2008
Update on the pathogenesis of Parkinson's disease.Journal of neurology, , Volume: 255 Suppl 5, 2008
Lrrk2 and alpha-synuclein are co-regulated in rodent striatum.Molecular and cellular neurosciences, , Volume: 39, Issue:4, 2008
Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:10, 2008
Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors.BMC neuroscience, , Sep-22, Volume: 9, 2008
Mathematical approach to understand the kinetics of alpha-synuclein aggregation: relevance to Parkinson's disease.Computers in biology and medicine, , Volume: 38, Issue:10, 2008
N-terminal region of alpha-synuclein is essential for the fatty acid-induced oligomerization of the molecules.FEBS letters, , Oct-29, Volume: 582, Issue:25-26, 2008
Re: Alpha-synuclein gene duplication is present in sporadic Parkinson disease.Neurology, , Oct-14, Volume: 71, Issue:16, 2008
Re: Alpha-synuclein gene duplication is present in sporadic Parkinson disease.Neurology, , Oct-14, Volume: 71, Issue:16, 2008
Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region.PloS one, , Volume: 3, Issue:10, 2008
On the pathogenesis and neuroprotective treatment of Parkinson disease: what have we learned from the genetic forms of this disease?Current medicinal chemistry, , Volume: 15, Issue:23, 2008
[Alpha-synuclein interacted proteins: the relevance with the pathogenesis of Parkinson's disease].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, , Volume: 37, Issue:5, 2008
Membrane binding of oligomeric alpha-synuclein depends on bilayer charge and packing.FEBS letters, , Nov-12, Volume: 582, Issue:27, 2008
LRRK2 and parkin immunoreactivity in multiple system atrophy inclusions.Acta neuropathologica, , Volume: 116, Issue:6, 2008
Targeted overexpression of human alpha-synuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson disease.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:12, 2008
Emerging pathways in genetic Parkinson's disease.The FEBS journal, , Volume: 275, Issue:23, 2008
Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2.The FEBS journal, , Volume: 275, Issue:23, 2008
Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease.The FEBS journal, , Volume: 275, Issue:23, 2008
Pathological lesions in colonic biopsies during Parkinson's disease.Gut, , Volume: 57, Issue:12, 2008
Alpha-Synuclein conformation affects its tyrosine-dependent oxidative aggregation.Biochemistry, , Dec-23, Volume: 47, Issue:51, 2008
Application of a C. elegans dopamine neuron degeneration assay for the validation of potential Parkinson's disease genes.Journal of visualized experiments : JoVE, , Jul-18, Issue:17, 2008
A critical evaluation of the Braak staging scheme for Parkinson's disease.Annals of neurology, , Volume: 64, Issue:5, 2008
Alpha-synuclein assembly as a therapeutic target of Parkinson's disease and related disorders.Current pharmaceutical design, , Volume: 14, Issue:30, 2008
Pink1 suppresses alpha-synuclein-induced phenotypes in a Drosophila model of Parkinson's disease.Genome, , Volume: 51, Issue:12, 2008
What causes cell death in Parkinson's disease?Annals of neurology, , Volume: 64 Suppl 2, 2008
[Clinical and pathological study on early diagnosis of Parkinson's disease and dementia with Lewy bodies].Rinsho shinkeigaku = Clinical neurology, , Volume: 48, Issue:11, 2008
[Lewy body formation in Parkinson's disease: neurodegeneration or neuroprotection?].Rinsho shinkeigaku = Clinical neurology, , Volume: 48, Issue:11, 2008
[Recent progress in Parkinson's disease].Rinsho shinkeigaku = Clinical neurology, , Volume: 48, Issue:11, 2008
[Cellular pathophysiology of Parkinson's disease].Rinsho shinkeigaku = Clinical neurology, , Volume: 48, Issue:11, 2008
Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression.Neurobiology of aging, , Volume: 28, Issue:2, 2007
Identification of novel proteins associated with both alpha-synuclein and DJ-1.Molecular & cellular proteomics : MCP, , Volume: 6, Issue:5, 2007
Parkinson's disease genetic mutations increase cell susceptibility to stress: mutant alpha-synuclein enhances H2O2- and Sin-1-induced cell death.Neurobiology of aging, , Volume: 28, Issue:11, 2007
Glutathione S-transferase polymorphisms and onset age in alpha-synuclein A53T mutant Parkinson's disease.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, , Mar-05, Volume: 144B, Issue:2, 2007
Dynamics of tyrosine hydroxylase mediated regulation of dopamine synthesis.Journal of computational neuroscience, , Volume: 22, Issue:2, 2007
Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?Neurobiology of disease, , Volume: 25, Issue:1, 2007
Phosphorylation-dependent metal binding by alpha-synuclein peptide fragments.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, , Volume: 12, Issue:2, 2007
The ups and downs of alpha-synuclein mRNA expression.Movement disorders : official journal of the Movement Disorder Society, , Jan-15, Volume: 22, Issue:2, 2007
Neuropathology of Parkinson's disease associated with the LRRK2 Ile1371Val mutation.Movement disorders : official journal of the Movement Disorder Society, , Jan-15, Volume: 22, Issue:2, 2007
Vitamin A potently destabilizes preformed alpha-synuclein fibrils in vitro: implications for Lewy body diseases.Neurobiology of disease, , Volume: 25, Issue:2, 2007
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.The Journal of biological chemistry, , Feb-23, Volume: 282, Issue:8, 2007
Effect of 4-hydroxy-2-nonenal modification on alpha-synuclein aggregation.The Journal of biological chemistry, , Feb-23, Volume: 282, Issue:8, 2007
Protein expression in a Drosophila model of Parkinson's disease.Journal of proteome research, , Volume: 6, Issue:1, 2007
Dopamine affects the stability, hydration, and packing of protofibrils and fibrils of the wild type and variants of alpha-synuclein.Biochemistry, , Jan-16, Volume: 46, Issue:2, 2007
Isomers of human alpha-synuclein stabilized by disulfide bonds exhibit distinct structural and aggregative properties.Biochemistry, , Jan-16, Volume: 46, Issue:2, 2007
PINK1, a gene product of PARK6, accumulates in alpha-synucleinopathy brains.Journal of neurology, neurosurgery, and psychiatry, , Volume: 78, Issue:6, 2007
Screening for SNCA and LRRK2 mutations in Greek sporadic and autosomal dominant Parkinson's disease: identification of two novel LRRK2 variants.European journal of neurology, , Volume: 14, Issue:1, 2007
Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity.Journal of molecular biology, , Mar-09, Volume: 366, Issue:5, 2007
The dopaminergic nigrostriatal system and Parkinson's disease: molecular events in development, disease, and cell death, and new therapeutic strategies.Neurosurgery, , Volume: 60, Issue:1, 2007
Activation of the unfolded protein response in Parkinson's disease.Biochemical and biophysical research communications, , Mar-16, Volume: 354, Issue:3, 2007
Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD.Experimental neurology, , Volume: 204, Issue:1, 2007
Pesticide exposure exacerbates alpha-synucleinopathy in an A53T transgenic mouse model.The American journal of pathology, , Volume: 170, Issue:2, 2007
Plasma alpha-synuclein is decreased in subjects with Parkinson's disease.Experimental neurology, , Volume: 204, Issue:2, 2007
Association of alpha-synuclein gene haplotypes with Parkinson's disease.Parkinsonism & related disorders, , Volume: 13, Issue:6, 2007
Parkinson's disease: lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre- and postganglionic neurons.Acta neuropathologica, , Volume: 113, Issue:4, 2007
Climbing the scaffolds of Parkinson's disease pathogenesis.Neuron, , Feb-15, Volume: 53, Issue:4, 2007
Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity.Neuron, , Feb-15, Volume: 53, Issue:4, 2007
Observation of multiple intermediates in alpha-synuclein fibril formation by singular value decomposition analysis.Biochemical and biophysical research communications, , Apr-06, Volume: 355, Issue:2, 2007
Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain.Brain : a journal of neurology, , Volume: 130, Issue:Pt 3, 2007
Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation.Human molecular genetics, , Mar-15, Volume: 16, Issue:6, 2007
Role of mitochondrial dysfunction in Parkinson's disease: Implications for treatment.Drugs & aging, , Volume: 24, Issue:2, 2007
The 5'-untranslated region of Parkinson's disease alpha-synuclein messengerRNA contains a predicted iron responsive element.Molecular psychiatry, , Volume: 12, Issue:3, 2007
Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation.The Journal of biological chemistry, , Apr-27, Volume: 282, Issue:17, 2007
Prime time for alpha-synuclein.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-07, Volume: 27, Issue:10, 2007
Expression of alpha-synuclein mRNA in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , May-15, Volume: 22, Issue:7, 2007
Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-21, Volume: 27, Issue:12, 2007
Pathogenic mutations in Parkinson disease.Human mutation, , Volume: 28, Issue:7, 2007
Transcranial ultrasound in different monogenetic subtypes of Parkinson's disease.Journal of neurology, , Volume: 254, Issue:5, 2007
A cell-based model of alpha-synucleinopathy for screening compounds with therapeutic potential of Parkinson's disease.Acta pharmacologica Sinica, , Volume: 28, Issue:5, 2007
Autoantibodies to alpha-synuclein in inherited Parkinson's disease.Journal of neurochemistry, , Volume: 101, Issue:3, 2007
Pharmacological inhibition of PARP-1 reduces alpha-synuclein- and MPP+-induced cytotoxicity in Parkinson's disease in vitro models.Biochemical and biophysical research communications, , Jun-08, Volume: 357, Issue:3, 2007
Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation.The American journal of pathology, , Volume: 170, Issue:5, 2007
Expanding insights on the involvement of endoplasmic reticulum stress in Parkinson's disease.Antioxidants & redox signaling, , Volume: 9, Issue:5, 2007
Expression of alpha-synuclein, a presynaptic protein implicated in Parkinson's disease, in erythropoietic lineage.Biochemical and biophysical research communications, , Jun-22, Volume: 358, Issue:1, 2007
The Ala53Thr mutation in the alpha-synuclein gene in a Korean family with Parkinson disease.Clinical genetics, , Volume: 71, Issue:5, 2007
Hypocretin (orexin) cell loss in Parkinson's disease.Brain : a journal of neurology, , Volume: 130, Issue:Pt 6, 2007
Therapeutic approaches to inflammation in neurodegenerative disease.Current opinion in neurology, , Volume: 20, Issue:3, 2007
Merging mouse transcriptome analyses with Parkinson's disease linkage studies.DNA research : an international journal for rapid publication of reports on genes and genomes, , Volume: 14, Issue:2, 2007
The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states.Biochemistry, , Jun-19, Volume: 46, Issue:24, 2007
Thermodynamics imprinting reveals differential binding of metals to alpha-synuclein: relevance to Parkinson's disease.Biochemical and biophysical research communications, , Jul-20, Volume: 359, Issue:1, 2007
Nitration in neurodegeneration: deciphering the "Hows" "nYs".Biochemistry, , Jun-26, Volume: 46, Issue:25, 2007
Do alpha-synuclein aggregates in autonomic plexuses predate Lewy body disorders?: a cohort study.Neurology, , Jun-05, Volume: 68, Issue:23, 2007
Alpha-synuclein pathology in the olfactory pathways of dementia patients.Journal of anatomy, , Volume: 211, Issue:1, 2007
Tilted properties of the 67-78 fragment of alpha-synuclein are responsible for membrane destabilization and neurotoxicity.Proteins, , Sep-01, Volume: 68, Issue:4, 2007
Autosomal dominant Parkinson's disease and the route to new therapies.Expert review of neurotherapeutics, , Volume: 7, Issue:6, 2007
Genetics of Parkinson's disease and parkinsonism.Expert review of neurotherapeutics, , Volume: 7, Issue:6, 2007
Development of alpha-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease.Acta neuropathologica, , Volume: 114, Issue:3, 2007
YGR198w (YPP1) targets A30P alpha-synuclein to the vacuole for degradation.The Journal of cell biology, , Jun-18, Volume: 177, Issue:6, 2007
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.Science (New York, N.Y.), , Jul-27, Volume: 317, Issue:5837, 2007
Effect of alpha-synuclein on the promoter activity of tyrosine hydroxylase gene.Neuroscience bulletin, , Volume: 23, Issue:1, 2007
Transgenic mice with human mutant genes causing Parkinson's disease and amyotrophic lateral sclerosis provide common insight into mechanisms of motor neuron selective vulnerability to degeneration.Reviews in the neurosciences, , Volume: 18, Issue:2, 2007
Classical Parkinson disease versus Parkinson complex--reflections against staging and in favour of heterogeneity.European journal of neurology, , Volume: 14, Issue:7, 2007
Physiological and pathological properties of alpha-synuclein.Cellular and molecular life sciences : CMLS, , Volume: 64, Issue:17, 2007
Impact of recent genetic findings in Parkinson's disease.Current opinion in neurology, , Volume: 20, Issue:4, 2007
Mechanistic aspects of Parkinson's disease: alpha-synuclein and the biomembrane.Cell biochemistry and biophysics, , Volume: 47, Issue:2, 2007
Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases.Acta neuropathologica, , Volume: 114, Issue:3, 2007
Medicine. The yin-yang of sirtuins.Science (New York, N.Y.), , Jul-27, Volume: 317, Issue:5837, 2007
Identification of proteins involved in microglial endocytosis of alpha-synuclein.Journal of proteome research, , Volume: 6, Issue:9, 2007
Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease.Annals of neurology, , Volume: 62, Issue:2, 2007
Lifetime proteomic profiling of an A30P alpha-synuclein Drosophila model of Parkinson's disease.Journal of proteome research, , Volume: 6, Issue:9, 2007
In parkinsonian substantia nigra, alpha-synuclein is modified by acrolein, a lipid-peroxidation product, and accumulates in the dopamine neurons with inhibition of proteasome activity.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 114, Issue:12, 2007
The effect of truncated human alpha-synuclein (1-120) on dopaminergic cells in a transgenic mouse model of Parkinson's disease.Cell transplantation, , Volume: 16, Issue:5, 2007
[Molecular genetics of Parkinson's disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 59, Issue:8, 2007
[Relationship between alpha-synuclein and Parkinson's disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 59, Issue:8, 2007
[Pathology of familial Parkinson's disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 59, Issue:8, 2007
Transgenic animal models of neurodegenerative diseases and their application to treatment development.Advanced drug delivery reviews, , Sep-30, Volume: 59, Issue:11, 2007
alpha-Synuclein and Parkinson disease susceptibility.Neurology, , Oct-30, Volume: 69, Issue:18, 2007
Conformation-specific binding of alpha-synuclein to novel protein partners detected by phage display and NMR spectroscopy.The Journal of biological chemistry, , Nov-23, Volume: 282, Issue:47, 2007
Angiotensin II protects against alpha-synuclein toxicity and reduces protein aggregation in vitro.Biochemical and biophysical research communications, , Nov-23, Volume: 363, Issue:3, 2007
Parkinson's disease.Human molecular genetics, , Oct-15, Volume: 16 Spec No. 2, 2007
Multiplex ligation-dependent probe amplification assay for simultaneous detection of Parkinson's disease gene rearrangements.Movement disorders : official journal of the Movement Disorder Society, , Nov-15, Volume: 22, Issue:15, 2007
Pathological biochemistry of alpha-synucleinopathy.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 27, Issue:5, 2007
The Lewy body in Parkinson's disease: molecules implicated in the formation and degradation of alpha-synuclein aggregates.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 27, Issue:5, 2007
Polyunsaturated fatty acids induce alpha-synuclein-related pathogenic changes in neuronal cells.The American journal of pathology, , Volume: 171, Issue:6, 2007
The pathogenesis of cell death in Parkinson's disease--2007.Movement disorders : official journal of the Movement Disorder Society, , Volume: 22 Suppl 17, 2007
Update on the genetics of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 22 Suppl 17, 2007
[Animal models for familial Parkinson's disease].Rinsho shinkeigaku = Clinical neurology, , Volume: 47, Issue:11, 2007
Neuropathology of Parkinson's disease dementia and dementia with Lewy bodies with reference to striatal pathology.Parkinsonism & related disorders, , Volume: 13 Suppl 3, 2007
Clinical genetics of Parkinson's disease and related disorders.Parkinsonism & related disorders, , Volume: 13 Suppl 3, 2007
Positron emission tomography changes in PARK1 mutation.Movement disorders : official journal of the Movement Disorder Society, , Volume: 21, Issue:1, 2006
Association of alpha-synuclein Rep1 polymorphism and Parkinson's disease: influence of Rep1 on age at onset.Movement disorders : official journal of the Movement Disorder Society, , Volume: 21, Issue:4, 2006
Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans.The Journal of biological chemistry, , Jan-06, Volume: 281, Issue:1, 2006
Secondary structure of alpha-synuclein oligomers: characterization by raman and atomic force microscopy.Journal of molecular biology, , Jan-06, Volume: 355, Issue:1, 2006
Nurr1 in Parkinson's disease and related disorders.The Journal of comparative neurology, , Jan-20, Volume: 494, Issue:3, 2006
Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology.Neuroscience letters, , Mar-20, Volume: 396, Issue:1, 2006
Dequalinium-induced protofibril formation of alpha-synuclein.The Journal of biological chemistry, , Feb-10, Volume: 281, Issue:6, 2006
NMR mapping of copper binding sites in alpha-synuclein.Biochimica et biophysica acta, , Volume: 1764, Issue:1, 2006
Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease.Annals of neurology, , Volume: 59, Issue:2, 2006
Prolyl-isomerase Pin1 accumulates in lewy bodies of parkinson disease and facilitates formation of alpha-synuclein inclusions.The Journal of biological chemistry, , Feb-17, Volume: 281, Issue:7, 2006
Evidence for novel loci for late-onset Parkinson's disease in a genetic isolate from the Netherlands.Human genetics, , Volume: 119, Issue:1-2, 2006
Positive immunoreactivity for vesicular monoamine transporter 2 in Lewy bodies and Lewy neurites in substantia nigra.Neuroscience letters, , Apr-03, Volume: 396, Issue:3, 2006
Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jan-04, Volume: 26, Issue:1, 2006
The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein.Journal of molecular biology, , Mar-03, Volume: 356, Issue:4, 2006
Dopamine transporter-mediated cytotoxicity of 6-hydroxydopamine in vitro depends on expression of mutant alpha-synucleins related to Parkinson's disease.Neurochemistry international, , Volume: 48, Issue:5, 2006
Biochemical and pathological characterization of Lrrk2.Annals of neurology, , Volume: 59, Issue:2, 2006
Pathology of the sympathetic nervous system corresponding to the decreased cardiac uptake in 123I-metaiodobenzylguanidine (MIBG) scintigraphy in a patient with Parkinson disease.Journal of the neurological sciences, , Apr-15, Volume: 243, Issue:1-2, 2006
Binding of alpha-synuclein affects the lipid packing in bilayers of small vesicles.The Journal of biological chemistry, , Apr-07, Volume: 281, Issue:14, 2006
[The wild-type alpha-synuclein over-expression to induce the protein aberrant aggregation of alpha-synuclein in HEK293 cells in vitro].Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, , Volume: 23, Issue:1, 2006
6-Hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation.The Journal of biological chemistry, , Apr-07, Volume: 281, Issue:14, 2006
The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 113, Issue:10, 2006
Reactive macrophages increase oxidative stress and alpha-synuclein nitration during death of dopaminergic neuronal cells in co-culture: relevance to Parkinson's disease.Neurochemical research, , Volume: 31, Issue:1, 2006
Expanding insights of mitochondrial dysfunction in Parkinson's disease.Nature reviews. Neuroscience, , Volume: 7, Issue:3, 2006
Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease.Human molecular genetics, , Apr-01, Volume: 15, Issue:7, 2006
Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 20, Issue:3, 2006
Abnormal alpha-synuclein solubility, aggregation and nitration in the frontal cortex in Pick's disease.Neuroscience letters, , May-29, Volume: 400, Issue:1-2, 2006
Drosophila models pioneer a new approach to drug discovery for Parkinson's disease.Drug discovery today, , Volume: 11, Issue:3-4, 2006
Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases.Proceedings of the National Academy of Sciences of the United States of America, , Mar-14, Volume: 103, Issue:11, 2006
Epidemiological, clinical, and genetic characteristics of early-onset parkinsonism.The Lancet. Neurology, , Volume: 5, Issue:4, 2006
Gene dosage analysis of alpha-synuclein (SNCA) in patients with Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 21, Issue:5, 2006
No alterations in alpha-synuclein gene dosage observed in sporadic Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 21, Issue:5, 2006
Alpha-synuclein facilitates the toxicity of oxidized catechol metabolites: implications for selective neurodegeneration in Parkinson's disease.FEBS letters, , Apr-03, Volume: 580, Issue:8, 2006
Identification of rotenone-induced modifications in alpha-synuclein using affinity pull-down and tandem mass spectrometry.Analytical chemistry, , Apr-01, Volume: 78, Issue:7, 2006
Proteasomal inhibition hypersensitizes differentiated neuroblastoma cells to oxidative damage.Neuroscience letters, , May-15, Volume: 399, Issue:1-2, 2006
[Subthalamic stimulation in a patient with multiple system atrophy: a clinicopathological report].Revue neurologique, , Volume: 162, Issue:3, 2006
Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients.Proceedings of the National Academy of Sciences of the United States of America, , Apr-11, Volume: 103, Issue:15, 2006
Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Apr-05, Volume: 26, Issue:14, 2006
Intragastric proteasome inhibition induces alpha-synuclein-immunopositive aggregations in neurons in the dorsal motor nucleus of the vagus in rats.Neuroscience letters, , Jun-19, Volume: 401, Issue:1-2, 2006
alpha-Synuclein promoter RsaI T-to-C polymorphism and the risk of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 113, Issue:10, 2006
Plasma membrane ion permeability induced by mutant alpha-synuclein contributes to the degeneration of neural cells.Journal of neurochemistry, , Volume: 97, Issue:4, 2006
Characterization of tau pathologies in gray and white matter of Guam parkinsonism-dementia complex.Acta neuropathologica, , Volume: 111, Issue:5, 2006
The role of chaperones in Parkinson's disease and prion diseases.Handbook of experimental pharmacology, , Issue:172, 2006
Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Apr-12, Volume: 26, Issue:15, 2006
Anticipation of onset age in familial Parkinson's disease without SCA gene mutations.Parkinsonism & related disorders, , Volume: 12, Issue:5, 2006
Biochemical staging of synucleinopathy and amyloid deposition in dementia with Lewy bodies.Journal of neuropathology and experimental neurology, , Volume: 65, Issue:3, 2006
Melanized nigral neuronal numbers in Nigerian and British individuals.Movement disorders : official journal of the Movement Disorder Society, , Volume: 21, Issue:8, 2006
Heat shock proteins reduce alpha-synuclein aggregation induced by MPP+ in SK-N-SH cells.FEBS letters, , May-29, Volume: 580, Issue:13, 2006
alpha-Synuclein budding yeast model: toxicity enhanced by impaired proteasome and oxidative stress.Journal of molecular neuroscience : MN, , Volume: 28, Issue:2, 2006
alpha-Synuclein fission yeast model: concentration-dependent aggregation without plasma membrane localization or toxicity.Journal of molecular neuroscience : MN, , Volume: 28, Issue:2, 2006
P25alpha immunoreactivity in multiple system atrophy and Parkinson disease.Acta neuropathologica, , Volume: 112, Issue:1, 2006
Proteasome dysfunction in aged human alpha-synuclein transgenic mice.Neurobiology of disease, , Volume: 23, Issue:1, 2006
Regional alpha-synuclein aggregation, dopaminergic dysregulation, and the development of drug-related visual hallucinations in Parkinson's disease.The Journal of neuropsychiatry and clinical neurosciences, ,Spring, Volume: 18, Issue:2, 2006
Inhibitors of alpha-synuclein oligomerization and toxicity: a future therapeutic strategy for Parkinson's disease and related disorders.Experimental brain research, , Volume: 173, Issue:2, 2006
Secondary structural formation of alpha-synuclein amyloids as revealed by g-factor of solid-state circular dichroism.Biopolymers, , Oct-15, Volume: 83, Issue:3, 2006
Is neuromelanin changed in Parkinson's disease? Investigations by magnetic spectroscopies.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 113, Issue:6, 2006
A novel mechanism of interaction between alpha-synuclein and biological membranes.Journal of molecular biology, , Jul-07, Volume: 360, Issue:2, 2006
Mutant alpha-synuclein-induced degeneration is reduced by parkin in a fly model of Parkinson's disease.Genome, , Volume: 49, Issue:5, 2006
Interaction of alpha-synuclein and dopamine metabolites in the pathogenesis of Parkinson's disease: a case for the selective vulnerability of the substantia nigra.Acta neuropathologica, , Volume: 112, Issue:2, 2006
Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients.Movement disorders : official journal of the Movement Disorder Society, , Volume: 21, Issue:10, 2006
Chaperone-like activities of alpha-synuclein: alpha-synuclein assists enzyme activities of esterases.Biochemical and biophysical research communications, , Aug-11, Volume: 346, Issue:4, 2006
Embryonic stem cell-derived neuron models of Parkinson's disease exhibit delayed neuronal death.Journal of neurochemistry, , Volume: 98, Issue:1, 2006
Novel covalent modifications of alpha-synuclein during the recovery from proteasomal dysfunction.Biochemical and biophysical research communications, , Aug-11, Volume: 346, Issue:4, 2006
Ventral tegmental area dopamine neurons are resistant to human mutant alpha-synuclein overexpression.Neurobiology of disease, , Volume: 23, Issue:3, 2006
Diagnosis and treatment of Parkinson disease: molecules to medicine.The Journal of clinical investigation, , Volume: 116, Issue:7, 2006
[Amyloid-beta protein vaccine therapy for alzheimer's disease].Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, , Jun-10, Volume: 95, Issue:6, 2006
LRRK2 protein is a component of Lewy bodies.Annals of neurology, , Volume: 60, Issue:5, 2006
Linker histone H1 binds to disease associated amyloid-like fibrils.Journal of molecular biology, , Aug-18, Volume: 361, Issue:3, 2006
Fragmentation of Golgi apparatus of nigral neurons with alpha-synuclein-positive inclusions in patients with Parkinson's disease.Acta neuropathologica, , Volume: 112, Issue:3, 2006
Highly potent and specific GSK-3beta inhibitors that block tau phosphorylation and decrease alpha-synuclein protein expression in a cellular model of Parkinson's disease.ChemMedChem, , Volume: 1, Issue:2, 2006
Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease.JAMA, , Aug-09, Volume: 296, Issue:6, 2006
Relationship among alpha-synuclein accumulation, dopamine synthesis, and neurodegeneration in Parkinson disease substantia nigra.Journal of neuropathology and experimental neurology, , Volume: 65, Issue:8, 2006
Beta-amlyoid 1-42 and tau-protein in cerebrospinal fluid of patients with Parkinson's disease dementia.Dementia and geriatric cognitive disorders, , Volume: 22, Issue:3, 2006
alpha-synuclein from platelets is not phosphorylated at serine 129 in Parkinson's disease and multiple system atrophy.Neuroscience letters, , Sep-25, Volume: 405, Issue:3, 2006
Nuclear localization of the 20S proteasome subunit in Parkinson's disease.Neuroscience letters, , Oct-02, Volume: 406, Issue:1-2, 2006
Dynamic modeling of alpha-synuclein aggregation for the sporadic and genetic forms of Parkinson's disease.Neuroscience, , Oct-27, Volume: 142, Issue:3, 2006
[Ubiquitin and Parkinson's disease].Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, , Volume: 51, Issue:10 Suppl, 2006
Cytosolic proteins regulate alpha-synuclein dissociation from presynaptic membranes.The Journal of biological chemistry, , Oct-27, Volume: 281, Issue:43, 2006
Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease.Biochemical and biophysical research communications, , Oct-13, Volume: 349, Issue:1, 2006
Behavioral effects of dopaminergic agonists in transgenic mice overexpressing human wildtype alpha-synuclein.Neuroscience, , Nov-03, Volume: 142, Issue:4, 2006
No definitive evidence for a role for the environment in the etiology of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 21, Issue:10, 2006
Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease.Neurochemical research, , Volume: 31, Issue:9, 2006
Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease.Experimental & molecular medicine, , Aug-31, Volume: 38, Issue:4, 2006
The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Sep-06, Volume: 26, Issue:36, 2006
alpha-Synuclein is colocalized with 14-3-3 and synphilin-1 in A53T transgenic mice.Acta neuropathologica, , Volume: 112, Issue:6, 2006
Beta-synuclein modulates alpha-synuclein neurotoxicity by reducing alpha-synuclein protein expression.Human molecular genetics, , Oct-15, Volume: 15, Issue:20, 2006
Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity.Human molecular genetics, , Oct-15, Volume: 15, Issue:20, 2006
PEP-1-SOD fusion protein efficiently protects against paraquat-induced dopaminergic neuron damage in a Parkinson disease mouse model.Free radical biology & medicine, , Oct-01, Volume: 41, Issue:7, 2006
Synphilin isoforms and the search for a cellular model of lewy body formation in Parkinson's disease.Cell cycle (Georgetown, Tex.), , Volume: 5, Issue:18, 2006
Histone deacetylase (HDAC) 4 involvement in both Lewy and Marinesco bodies.Neuropathology and applied neurobiology, , Volume: 32, Issue:5, 2006
The aggregation and fibrillation of alpha-synuclein.Accounts of chemical research, , Volume: 39, Issue:9, 2006
Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells.Journal of neurochemistry, , Volume: 99, Issue:4, 2006
A spectroscopic study of some of the peptidyl radicals formed following hydroxyl radical attack on beta-amyloid and alpha-synuclein.Free radical research, , Volume: 40, Issue:7, 2006
Isolating recombinant antibodies against specific protein morphologies using atomic force microscopy and phage display technologies.Protein engineering, design & selection : PEDS, , Volume: 19, Issue:11, 2006
[Familial Parkinsonism].No to shinkei = Brain and nerve, , Volume: 58, Issue:8, 2006
[What can we learn from genes responsible for familial forms of Parkinson's disease?].Bulletin de l'Academie nationale de medecine, , Volume: 190, Issue:2, 2006
Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Sep-27, Volume: 26, Issue:39, 2006
Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery.Neuron, , Oct-05, Volume: 52, Issue:1, 2006
Pathology associated with sporadic Parkinson's disease--where does it end?Journal of neural transmission. Supplementum, , Issue:70, 2006
New face of neuromelanin.Journal of neural transmission. Supplementum, , Issue:70, 2006
Genetic causes of Parkinson's disease: extending the pathway.Journal of neural transmission. Supplementum, , Issue:70, 2006
Progress in familial Parkinson's disease.Journal of neural transmission. Supplementum, , Issue:70, 2006
Molecular mechanisms of nigral neurodegeneration in Park2 and regulation of parkin protein by other proteins.Journal of neural transmission. Supplementum, , Issue:70, 2006
Understanding the molecular causes of Parkinson's disease.Trends in molecular medicine, , Volume: 12, Issue:11, 2006
Genetics of Parkinson's disease and parkinsonism.Annals of neurology, , Volume: 60, Issue:4, 2006
Identification of a risk haplotype of the alpha-synuclein gene in Japanese with sporadic Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 21, Issue:12, 2006
Cortical Lewy body disease and Parkinson's disease dementia.Current opinion in neurology, , Volume: 19, Issue:6, 2006
Viral vectors as a tool to model and treat Parkinson's disease.Wiener klinische Wochenschrift, , Volume: 118, Issue:19-20, 2006
[The neuroprotective B2 strengthens the aggregation of unfolded protein in Huntington chorea and Parkinson disease].Pharmazie in unserer Zeit, , Volume: 35, Issue:6, 2006
alpha-Synuclein, oxidative stress and apoptosis from the perspective of a yeast model of Parkinson's disease.FEMS yeast research, , Volume: 6, Issue:8, 2006
Impairment of microtubule-dependent trafficking by overexpression of alpha-synuclein.The European journal of neuroscience, , Volume: 24, Issue:11, 2006
Differences in neuropathologic characteristics across the Lewy body dementia spectrum.Neurology, , Dec-12, Volume: 67, Issue:11, 2006
Rescuing defective vesicular trafficking protects against alpha-synuclein toxicity in cellular and animal models of Parkinson's disease.ACS chemical biology, , Aug-22, Volume: 1, Issue:7, 2006
Effect of reparation of repeat sequences in the human alpha-synuclein on fibrillation ability.International journal of biological sciences, , Oct-02, Volume: 3, Issue:1, 2006
[Parkinson's disease dementia and Lewy body dementia].Psychologie & neuropsychiatrie du vieillissement, , Volume: 4 Spec No 1, 2006
Analysis of the polymorphic prion protein gene codon 129 in idiopathic Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 113, Issue:3, 2006
A combinatorial code for the interaction of alpha-synuclein with membranes.The Journal of biological chemistry, , Sep-09, Volume: 280, Issue:36, 2005
Genetics of Parkinson's disease.Annals of medicine, , Volume: 37, Issue:2, 2005
Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20, Issue:11, 2005
Haploinsufficiency for trkB and trkC receptors induces cell loss and accumulation of alpha-synuclein in the substantia nigra.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 19, Issue:12, 2005
Agrin binds alpha-synuclein and modulates alpha-synuclein fibrillation.Glycobiology, , Volume: 15, Issue:12, 2005
Staging of sporadic Parkinson disease-related alpha-synuclein pathology: inter- and intra-rater reliability.Journal of neuropathology and experimental neurology, , Volume: 64, Issue:7, 2005
Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease.Journal of molecular biology, , Sep-02, Volume: 351, Issue:5, 2005
Engineered alpha-synuclein prevents wild type and familial Parkin variant fibril formation.Biochemical and biophysical research communications, , Sep-23, Volume: 335, Issue:2, 2005
Parkinson's disease: a broken nosology.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
How to diagnose dementia with Lewy bodies: state of the art.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
Alpha-synuclein dysfunction in Lewy body diseases.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
Nosology of Parkinson's disease: looking for the way out of a quagmire.Neuron, , Aug-18, Volume: 47, Issue:4, 2005
Localization of alpha-synuclein to identified fibers and synapses in the normal mouse brain.Neuroscience, , Volume: 135, Issue:3, 2005
Molecular pathogenesis of Parkinson's disease.Human molecular genetics, , Sep-15, Volume: 14, Issue:18, 2005
Evidence of oxidative stress in the neocortex in incidental Lewy body disease.Journal of neuropathology and experimental neurology, , Volume: 64, Issue:9, 2005
Effect of metals on herbicides-alpha-synuclein association: a possible factor in neurodegenerative disease studied by capillary electrophoresis.Electrophoresis, , Volume: 26, Issue:17, 2005
Amyloid fibril formation of alpha-synuclein is accelerated by preformed amyloid seeds of other proteins: implications for the mechanism of transmissible conformational diseases.The Journal of biological chemistry, , Nov-18, Volume: 280, Issue:46, 2005
Comparison of structure and dynamics of micelle-bound human alpha-synuclein and Parkinson disease variants.The Journal of biological chemistry, , Dec-30, Volume: 280, Issue:52, 2005
Molecular genetic pathways in Parkinson's disease: a review.Clinical science (London, England : 1979), , Volume: 109, Issue:4, 2005
Characterization of oligomeric intermediates in alpha-synuclein fibrillation: FRET studies of Y125W/Y133F/Y136F alpha-synuclein.Journal of molecular biology, , Oct-21, Volume: 353, Issue:2, 2005
Genetics of Parkinson's disease.Minerva medica, , Volume: 96, Issue:3, 2005
The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy.British journal of pharmacology, , Volume: 146, Issue:8, 2005
A possible role for humoral immunity in the pathogenesis of Parkinson's disease.Brain : a journal of neurology, , Volume: 128, Issue:Pt 11, 2005
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.The Journal of biological chemistry, , Dec-30, Volume: 280, Issue:52, 2005
Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity.Human molecular genetics, , Dec-15, Volume: 14, Issue:24, 2005
Metal ions and oxidative protein modification in neurological disease.Annali dell'Istituto superiore di sanita, , Volume: 41, Issue:2, 2005
Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein.Molecular and cellular biology, , Volume: 25, Issue:22, 2005
Snaring the function of alpha-synuclein.Cell, , Nov-04, Volume: 123, Issue:3, 2005
How genetics research in Parkinson's disease is enhancing understanding of the common idiopathic forms of the disease.Current opinion in neurology, , Volume: 18, Issue:6, 2005
Neuroscientists put gene therapy into reverse.Nature, , Nov-24, Volume: 438, Issue:7067, 2005
Marmoset monkey models of Parkinson's disease: which model, when and why?Brain research bulletin, , Dec-30, Volume: 68, Issue:3, 2005
Genetic mouse models of parkinsonism: strengths and limitations.NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 2, Issue:3, 2005
[Pathogenesis of Parkinson's disease: implications from familial Parkinson's disease].Rinsho shinkeigaku = Clinical neurology, , Volume: 45, Issue:11, 2005
[Pathogenesis of Parkinson's disease: a common pathway between alpha-synuclein and parkin and the mechanism of Lewy bodies formation].Rinsho shinkeigaku = Clinical neurology, , Volume: 45, Issue:11, 2005
Protein denaturation and aggregation: Cellular responses to denatured and aggregated proteins.Annals of the New York Academy of Sciences, , Volume: 1066, 2005
Genetic testing in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20, Issue:1, 2005
Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila.The Journal of biological chemistry, , Jan-28, Volume: 280, Issue:4, 2005
Exacerbated synucleinopathy in mice expressing A53T SNCA on a Snca null background.Neurobiology of aging, , Volume: 26, Issue:1, 2005
Metal-catalyzed oxidation of alpha-synuclein: helping to define the relationship between oligomers, protofibrils, and filaments.The Journal of biological chemistry, , Mar-11, Volume: 280, Issue:10, 2005
The role of alpha-synuclein gene multiplications in early-onset Parkinson's disease and dementia with Lewy bodies.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 112, Issue:9, 2005
Ubiquitination of alpha-synuclein.Biochemistry, , Jan-11, Volume: 44, Issue:1, 2005
Ubiquitin-proteasome system and Parkinson's diseases.Experimental neurology, , Volume: 191 Suppl 1, 2005
Failure to find alpha-synuclein gene dosage changes in 190 patients with familial Parkinson disease.Archives of neurology, , Volume: 62, Issue:1, 2005
Australian data and meta-analysis lend support for alpha-synuclein (NACP-Rep1) as a risk factor for Parkinson's disease.Neuroscience letters, , Feb-28, Volume: 375, Issue:2, 2005
Regulation of alpha-synuclein expression by poly (ADP ribose) polymerase-1 (PARP-1) binding to the NACP-Rep1 polymorphic site upstream of the SNCA gene.American journal of human genetics, , Volume: 76, Issue:3, 2005
Pro-apoptotic protein glyceraldehyde-3-phosphate dehydrogenase promotes the formation of Lewy body-like inclusions.The European journal of neuroscience, , Volume: 21, Issue:2, 2005
Methionine oxidation, alpha-synuclein and Parkinson's disease.Biochimica et biophysica acta, , Jan-17, Volume: 1703, Issue:2, 2005
Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations.Proceedings of the National Academy of Sciences of the United States of America, , Feb-08, Volume: 102, Issue:6, 2005
Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains.The Journal of biological chemistry, , Apr-29, Volume: 280, Issue:17, 2005
Alpha-synuclein mRNA expression in sporadic Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20, Issue:5, 2005
Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-23, Volume: 25, Issue:8, 2005
Interaction of alpha-synuclein and tau genotypes in Parkinson's disease.Annals of neurology, , Volume: 57, Issue:3, 2005
Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA).Journal of neuropathology and experimental neurology, , Volume: 64, Issue:2, 2005
Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein.Experimental neurology, , Volume: 192, Issue:2, 2005
Mitochondrial associated metabolic proteins are selectively oxidized in A30P alpha-synuclein transgenic mice--a model of familial Parkinson's disease.Neurobiology of disease, , Volume: 18, Issue:3, 2005
Gene dosage and pathogenesis of Parkinson's disease.Trends in molecular medicine, , Volume: 11, Issue:3, 2005
Parkin gene therapy for alpha-synucleinopathy: a rat model of Parkinson's disease.Human gene therapy, , Volume: 16, Issue:2, 2005
Structural characterization of copper(II) binding to alpha-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , Mar-22, Volume: 102, Issue:12, 2005
A case of late onset sporadic Parkinson's disease with an A53T mutation in alpha-synuclein.Journal of neurology, neurosurgery, and psychiatry, , Volume: 76, Issue:4, 2005
Multiple regions of alpha-synuclein are associated with Parkinson's disease.Annals of neurology, , Volume: 57, Issue:4, 2005
Whole-mount analysis reveals normal numbers of dopaminergic neurons following misexpression of alpha-Synuclein in Drosophila.Genesis (New York, N.Y. : 2000), , Volume: 41, Issue:4, 2005
Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson's disease?Brain research. Molecular brain research, , Mar-24, Volume: 134, Issue:1, 2005
Metallothionein-mediated neuroprotection in genetically engineered mouse models of Parkinson's disease.Brain research. Molecular brain research, , Mar-24, Volume: 134, Issue:1, 2005
The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis.Human molecular genetics, , May-01, Volume: 14, Issue:9, 2005
Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 19, Issue:6, 2005
Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations.The Journal of biological chemistry, , Jun-03, Volume: 280, Issue:22, 2005
Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease.Nature neuroscience, , Volume: 8, Issue:5, 2005
A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease.The Journal of biological chemistry, , Jun-17, Volume: 280, Issue:24, 2005
Sins of synuclein.Science of aging knowledge environment : SAGE KE, , Apr-20, Volume: 2005, Issue:16, 2005
Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases.The Journal of biological chemistry, , Jul-01, Volume: 280, Issue:26, 2005
Controversy: is Parkinson's disease a single disease entity? Yes.Parkinsonism & related disorders, , Volume: 11 Suppl 1, 2005
Alpha-synuclein and Parkinson's disease: implications from the screening of more than 1,900 patients.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20, Issue:9, 2005
Common anti-apoptotic roles of parkin and alpha-synuclein in human dopaminergic cells.Biochemical and biophysical research communications, , Jun-24, Volume: 332, Issue:1, 2005
Skin and platelet alpha-synuclein as peripheral biomarkers of Parkinson's disease.Neuroscience letters, , Jun-24, Volume: 381, Issue:3, 2005
Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein.Biochemistry, , May-31, Volume: 44, Issue:21, 2005
DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein.Journal of neurochemistry, , Volume: 93, Issue:6, 2005
Antiapoptotic property of human alpha-synuclein in neuronal cell lines is associated with the inhibition of caspase-3 but not caspase-9 activity.Journal of neurochemistry, , Volume: 93, Issue:6, 2005
Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 19, Issue:10, 2005
The biochemistry of Parkinson's disease.Annual review of biochemistry, , Volume: 74, 2005
Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease.Neuron, , Jun-16, Volume: 46, Issue:6, 2005
Altered alpha-synuclein homeostasis causing Parkinson's disease: the potential roles of dardarin.Trends in neurosciences, , Volume: 28, Issue:8, 2005
Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20, Issue:9, 2005
Sticking it to Parkinson's disease.Science of aging knowledge environment : SAGE KE, , Jun-22, Volume: 2005, Issue:25, 2005
Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA).Journal of neuropathology and experimental neurology, , Volume: 64, Issue:6, 2005
Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease.Brain : a journal of neurology, , Volume: 128, Issue:Pt 11, 2005
Silver stainings distinguish Lewy bodies and glial cytoplasmic inclusions: comparison between Gallyas-Braak and Campbell-Switzer methods.Acta neuropathologica, , Volume: 110, Issue:3, 2005
A comparison of degeneration in motor thalamus and cortex between progressive supranuclear palsy and Parkinson's disease.Brain : a journal of neurology, , Volume: 128, Issue:Pt 10, 2005
Influence of different promoters on the expression pattern of mutated human alpha-synuclein in transgenic mice.Neuro-degenerative diseases, , Volume: 1, Issue:6, 2004
Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective.The Journal of biological chemistry, , Feb-06, Volume: 279, Issue:6, 2004
Alpha-synuclein haplotypes implicated in risk of Parkinson's disease.Neurology, , Jan-13, Volume: 62, Issue:1, 2004
Proteasome inhibition and aggregation in Parkinson's disease: a comparative study in untransfected and transfected cells.Journal of neurochemistry, , Volume: 88, Issue:3, 2004
Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy.Acta neuropathologica, , Volume: 107, Issue:4, 2004
Association between cardiac denervation and parkinsonism caused by alpha-synuclein gene triplication.Brain : a journal of neurology, , Volume: 127, Issue:Pt 4, 2004
Alpha-synuclein in Parkinson's disease: light from two new angles.Annals of neurology, , Volume: 55, Issue:2, 2004
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia.Annals of neurology, , Volume: 55, Issue:2, 2004
Parkinson's disease transgenic mitochondrial cybrids generate Lewy inclusion bodies.Journal of neurochemistry, , Volume: 88, Issue:4, 2004
Alteration in alpha-synuclein mRNA expression in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 19, Issue:2, 2004
Parkin and alpha-synuclein: opponent actions in the pathogenesis of Parkinson's disease.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, , Volume: 10, Issue:1, 2004
Pael-R is accumulated in Lewy bodies of Parkinson's disease.Annals of neurology, , Volume: 55, Issue:3, 2004
Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons.Journal of cell science, , Mar-01, Volume: 117, Issue:Pt 7, 2004
Chasing genes in Alzheimer's and Parkinson's disease.Human genetics, , Volume: 114, Issue:5, 2004
Tissue transglutaminase catalyzes the formation of alpha-synuclein crosslinks in Parkinson's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 18, Issue:7, 2004
Commentary on "Alpha-synuclein and mitochondria: a tangled skein".Experimental neurology, , Volume: 186, Issue:2, 2004
Beta-synuclein regulates Akt activity in neuronal cells. A possible mechanism for neuroprotection in Parkinson's disease.The Journal of biological chemistry, , May-28, Volume: 279, Issue:22, 2004
alpha-Synuclein A53T substitution associated with Parkinson disease also marks the divergence of Old World and New World primates.Genomics, , Volume: 83, Issue:4, 2004
Structural determinants of PLD2 inhibition by alpha-synuclein.Journal of molecular biology, , Apr-02, Volume: 337, Issue:4, 2004
Alpha-synuclein and Parkinson's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 18, Issue:6, 2004
Does alpha-synuclein modulate dopaminergic synaptic content and tone at the synapse?FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 18, Issue:6, 2004
Dopamine and L-dopa disaggregate amyloid fibrils: implications for Parkinson's and Alzheimer's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 18, Issue:9, 2004
Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , Apr-13, Volume: 101, Issue:15, 2004
Parkin counteracts symptoms in a Drosophila model of Parkinson's disease.BMC neuroscience, , Apr-16, Volume: 5, 2004
Alpha-synuclein: normal function and role in neurodegenerative diseases.Current topics in developmental biology, , Volume: 60, 2004
Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein.Biochemistry, , Apr-27, Volume: 43, Issue:16, 2004
NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation.The EMBO journal, , May-19, Volume: 23, Issue:10, 2004
Alpha-synuclein, Parkinson's disease, and Alzheimer's disease.Parkinsonism & related disorders, , Volume: 10 Suppl 1, 2004
Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease.Journal of molecular neuroscience : MN, , Volume: 23, Issue:1-2, 2004
alpha-Synuclein regulation of the dopaminergic transporter: a possible role in the pathogenesis of Parkinson's disease.FEBS letters, , May-07, Volume: 565, Issue:1-3, 2004
Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation.Experimental neurology, , Volume: 187, Issue:2, 2004
Alpha-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication.Neurology, , May-25, Volume: 62, Issue:10, 2004
A strategy for designing inhibitors of alpha-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 18, Issue:11, 2004
Proteomic approach to studying Parkinson's disease.Molecular neurobiology, , Volume: 29, Issue:3, 2004
Alpha-synuclein and the pathogenesis of Parkinson's disease.Protein and peptide letters, , Volume: 11, Issue:3, 2004
Alpha-synuclein aggregation.Protein and peptide letters, , Volume: 11, Issue:3, 2004
ABri peptide associated with familial British dementia forms annular and ring-like protofibrillar structures.Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, , Volume: 11, Issue:1, 2004
Could a loss of alpha-synuclein function put dopaminergic neurons at risk?Journal of neurochemistry, , Volume: 89, Issue:6, 2004
UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's disease.Journal of neurochemistry, , Volume: 90, Issue:2, 2004
Does cellular iron dysregulation play a causative role in Parkinson's disease?Ageing research reviews, , Volume: 3, Issue:3, 2004
Genes, proteins, and neurotoxins involved in Parkinson's disease.Progress in neurobiology, , Volume: 73, Issue:3, 2004
Unraveling the pathogenesis of Parkinson's disease--the contribution of monogenic forms.Cellular and molecular life sciences : CMLS, , Volume: 61, Issue:14, 2004
Alpha-synuclein induces apoptosis by altered expression in human peripheral lymphocyte in Parkinson's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 18, Issue:13, 2004
[The alpha-synuclein gene microsatellite polymorphism and late-onset sporadic Parkinson's disease susceptibility].Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, , Volume: 21, Issue:4, 2004
SNCA multiplication is not a common cause of Parkinson disease or dementia with Lewy bodies.Neurology, , Aug-10, Volume: 63, Issue:3, 2004
Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Aug-18, Volume: 24, Issue:33, 2004
Parkin-positive autosomal recessive juvenile Parkinsonism with alpha-synuclein-positive inclusions.Neurology, , Aug-24, Volume: 63, Issue:4, 2004
Protective effect of TAT-delivered alpha-synuclein: relevance of the C-terminal domain and involvement of HSP70.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 18, Issue:14, 2004
Beta-synuclein gene alterations in dementia with Lewy bodies.Neurology, , Sep-14, Volume: 63, Issue:5, 2004
Lack of alpha-synuclein does not alter apoptosis of neonatal catecholaminergic neurons.The European journal of neuroscience, , Volume: 20, Issue:7, 2004
Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease.Journal of neurochemistry, , Volume: 91, Issue:2, 2004
alpha-Synuclein promoter confers susceptibility to Parkinson's disease.Annals of neurology, , Volume: 56, Issue:4, 2004
Parkinson's disease: alpha-synuclein build-up explained.The Lancet. Neurology, , Volume: 3, Issue:10, 2004
[Molecular biology for familial Parkinson's disease].Nihon rinsho. Japanese journal of clinical medicine, , Volume: 62, Issue:9, 2004
[Analysis of alpha-synuclein and its significance].Nihon rinsho. Japanese journal of clinical medicine, , Volume: 62, Issue:9, 2004
alpha-Synuclein expression levels do not significantly affect proteasome function and expression in mice and stably transfected PC12 cell lines.The Journal of biological chemistry, , Dec-17, Volume: 279, Issue:51, 2004
Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease.Neurobiology of disease, , Volume: 17, Issue:2, 2004
Lewy body-related alpha-synucleinopathy in the aged human brain.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 111, Issue:10-11, 2004
Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein.FEBS letters, , Oct-22, Volume: 576, Issue:3, 2004
DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation.PLoS biology, , Volume: 2, Issue:11, 2004
Synucleins and their relationship to Parkinson's disease.Cell and tissue research, , Volume: 318, Issue:1, 2004
Absence of heparan sulfate proteoglycans in Lewy bodies and Lewy neurites in Parkinson's disease brains.Journal of Alzheimer's disease : JAD, , Volume: 6, Issue:5, 2004
A single amino acid substitution differentiates Hsp70-dependent effects on alpha-synuclein degradation and toxicity.Biochemical and biophysical research communications, , Dec-03, Volume: 325, Issue:1, 2004
Limbic neuropathology in idiopathic Parkinson's disease with concomitant dementia.Folia neuropathologica, , Volume: 42, Issue:3, 2004
Alpha-synuclein structures from fluorescence energy-transfer kinetics: implications for the role of the protein in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , Nov-23, Volume: 101, Issue:47, 2004
Targeting alpha-synuclein in Parkinson's disease.Chemistry & biology, , Volume: 11, Issue:11, 2004
Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , Dec-14, Volume: 101, Issue:50, 2004
alpha-Synuclein filaments bind the transcriptional regulator HMGB-1.Neuroreport, , Dec-22, Volume: 15, Issue:18, 2004
New aspects of genetic contributions to Parkinson's disease.Journal of molecular neuroscience : MN, , Volume: 24, Issue:3, 2004
Pathological proteins in Parkinson's disease: focus on the proteasome.Journal of molecular neuroscience : MN, , Volume: 24, Issue:3, 2004
Genetics of Parkinson disease.NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 1, Issue:2, 2004
Cellular polyamines promote the aggregation of alpha-synuclein.The Journal of biological chemistry, , Jan-31, Volume: 278, Issue:5, 2003
Alpha-synuclein and Parkinson's disease.Advances in neurology, , Volume: 91, 2003
Haploinsufficiency at the alpha-synuclein gene underlies phenotypic severity in familial Parkinson's disease.Brain : a journal of neurology, , Volume: 126, Issue:Pt 1, 2003
Alpha synuclein promoter and risk of Parkinson's disease: microsatellite and allelic size variability.Neuroscience letters, , Jan-09, Volume: 336, Issue:1, 2003
The N-terminal repeat domain of alpha-synuclein inhibits beta-sheet and amyloid fibril formation.Biochemistry, , Jan-28, Volume: 42, Issue:3, 2003
Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis.Biochemistry, , Jan-28, Volume: 42, Issue:3, 2003
Lewy bodies in Betz cells of the motor cortex in a patient with Parkinson's disease.Acta neuropathologica, , Volume: 105, Issue:2, 2003
Polymorphisms of the alpha-synuclein promoter: expression analyses and association studies in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 110, Issue:1, 2003
Nucleus-specific alteration of raphe neurons in human neurodegenerative disorders.Neuroreport, , Jan-20, Volume: 14, Issue:1, 2003
Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function.The Journal of biological chemistry, , Apr-04, Volume: 278, Issue:14, 2003
Recent advances on alpha-synuclein cell biology: functions and dysfunctions.Current molecular medicine, , Volume: 3, Issue:1, 2003
Tissue transglutaminase-induced aggregation of alpha-synuclein: Implications for Lewy body formation in Parkinson's disease and dementia with Lewy bodies.Proceedings of the National Academy of Sciences of the United States of America, , Feb-18, Volume: 100, Issue:4, 2003
Residual substantia nigra neuromelanin in Parkinson's disease is cross-linked to alpha-synuclein.Neurochemistry international, , Volume: 42, Issue:7, 2003
The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease.Neuron, , Feb-20, Volume: 37, Issue:4, 2003
Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , Mar-04, Volume: 100, Issue:5, 2003
Parkinson's disease-associated alpha-synuclein is a calmodulin substrate.The Journal of biological chemistry, , May-09, Volume: 278, Issue:19, 2003
Familial and sporadic Parkinson's disease usually display the same clinical features.Parkinsonism & related disorders, , Volume: 9, Issue:4, 2003
Lipid binding inhibits alpha-synuclein fibril formation.The Journal of biological chemistry, , May-09, Volume: 278, Issue:19, 2003
Alpha-synuclein pathology affecting Bergmann glia of the cerebellum in patients with alpha-synucleinopathies.Acta neuropathologica, , Volume: 105, Issue:4, 2003
Ubiquitinated inclusions and neuronal cell death.Histology and histopathology, , Volume: 18, Issue:2, 2003
Enhanced oligomerization of the alpha-synuclein mutant by the Cu,Zn-superoxide dismutase and hydrogen peroxide system.Molecules and cells, , Feb-28, Volume: 15, Issue:1, 2003
Proteolytic stress: a unifying concept for the etiopathogenesis of Parkinson's disease.Annals of neurology, , Volume: 53 Suppl 3, 2003
Beta-synuclein inhibits formation of alpha-synuclein protofibrils: a possible therapeutic strategy against Parkinson's disease.Biochemistry, , Apr-08, Volume: 42, Issue:13, 2003
Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila.Neuron, , Mar-27, Volume: 37, Issue:6, 2003
Association of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathies.The Journal of biological chemistry, , Jun-27, Volume: 278, Issue:26, 2003
Colocalization of tau and alpha-synuclein epitopes in Lewy bodies.Journal of neuropathology and experimental neurology, , Volume: 62, Issue:4, 2003
Differential cytotoxicity of dopamine and H2O2 in a human neuroblastoma divided cell line transfected with alpha-synuclein and its familial Parkinson's disease-linked mutants.Neuroscience letters, , May-15, Volume: 342, Issue:1-2, 2003
Nitration inhibits fibrillation of human alpha-synuclein in vitro by formation of soluble oligomers.FEBS letters, , May-08, Volume: 542, Issue:1-3, 2003
Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1.The Journal of biological chemistry, , Aug-01, Volume: 278, Issue:31, 2003
Clinical characteristics of the alpha-synuclein mutation (G209A)-associated Parkinson's disease in comparison with other forms of familial Parkinson's disease in Greece.European journal of neurology, , Volume: 10, Issue:3, 2003
Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease.Human molecular genetics, , Jun-01, Volume: 12, Issue:11, 2003
Therapeutic strategies for Parkinson's disease based on data derived from genetic research.Journal of neurology, , Volume: 250 Suppl 1, 2003
Complex interactions in Parkinson's disease: a two-phased approach.Movement disorders : official journal of the Movement Disorder Society, , Volume: 18, Issue:6, 2003
Alpha-synuclein up-regulates expression of caveolin-1 and down-regulates extracellular signal-regulated kinase activity in B103 neuroblastoma cells: role in the pathogenesis of Parkinson's disease.Journal of neurochemistry, , Volume: 85, Issue:6, 2003
Alpha-synuclein-positive structures in association with diffuse neurofibrillary tangles with calcification.Neuropathology and applied neurobiology, , Volume: 29, Issue:3, 2003
A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins.Journal of molecular biology, , Jun-13, Volume: 329, Issue:4, 2003
Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease.Neuropharmacology, , Volume: 45, Issue:1, 2003
Essential tremor is not associated with alpha-synuclein gene haplotypes.Movement disorders : official journal of the Movement Disorder Society, , Volume: 18, Issue:7, 2003
Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease.Biochemistry, , Jul-08, Volume: 42, Issue:26, 2003
[Parkinson's disease: what have we learned from the genes responsible for familial forms?].Medecine sciences : M/S, , Volume: 19, Issue:5, 2003
Parkinson's disease: alpha-synuclein and parkin in protein aggregation and the reversal of unfolded protein stress.Methods in molecular biology (Clifton, N.J.), , Volume: 232, 2003
Alpha-synuclein pathology in Parkinson's and Alzheimer's disease brain: incidence and topographic distribution--a pilot study.Acta neuropathologica, , Volume: 106, Issue:3, 2003
The cast of molecular characters in Parkinson's disease: felons, conspirators, and suspects.Annals of the New York Academy of Sciences, , Volume: 991, 2003
Modeling CNS neurodegeneration by overexpression of disease-causing proteins using viral vectors.Trends in neurosciences, , Volume: 26, Issue:7, 2003
Beta-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation: cross-talk with alpha-synuclein and implication for Parkinson's disease.The Journal of biological chemistry, , Sep-26, Volume: 278, Issue:39, 2003
Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis.The American journal of pathology, , Volume: 163, Issue:2, 2003
alpha-synuclein aggregation: a link between mitochondrial defects and Parkinson's disease?Antioxidants & redox signaling, , Volume: 5, Issue:3, 2003
Cell cycle aberrations by alpha-synuclein over-expression and cyclin B immunoreactivity in Lewy bodies.Neurobiology of aging, , Volume: 24, Issue:5, 2003
The association of alpha-synuclein with membranes affects bilayer structure, stability, and fibril formation.The Journal of biological chemistry, , Oct-10, Volume: 278, Issue:41, 2003
Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro.Journal of neurochemistry, , Volume: 86, Issue:4, 2003
Dissociation of amyloid fibrils of alpha-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities.Proceedings of the National Academy of Sciences of the United States of America, , Aug-19, Volume: 100, Issue:17, 2003
Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease.Human molecular genetics, , Oct-01, Volume: 12, Issue:19, 2003
Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function.The Journal of biological chemistry, , Nov-07, Volume: 278, Issue:45, 2003
Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies.Human molecular genetics, , Oct-15, Volume: 12, Issue:20, 2003
The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins?The Lancet. Neurology, , Volume: 2, Issue:9, 2003
What have we learnt from CDNA microarray gene expression studies about the role of iron in MPTP induced neurodegeneration and Parkinson's disease?Journal of neural transmission. Supplementum, , Issue:65, 2003
The role of alpha-synuclein in Parkinson's disease: insights from animal models.Nature reviews. Neuroscience, , Volume: 4, Issue:9, 2003
A protein-chameleon: conformational plasticity of alpha-synuclein, a disordered protein involved in neurodegenerative disorders.Journal of biomolecular structure & dynamics, , Volume: 21, Issue:2, 2003
Alpha-synuclein: between synaptic function and dysfunction.Histology and histopathology, , Volume: 18, Issue:4, 2003
Alpha-synuclein accumulates in Purkinje cells in Lewy body disease but not in multiple system atrophy.Journal of neuropathology and experimental neurology, , Volume: 62, Issue:8, 2003
Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains.Acta neuropathologica, , Volume: 106, Issue:6, 2003
Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 17, Issue:13, 2003
Alpha-synuclein oligomerization: a role for lipids?Trends in neurosciences, , Volume: 26, Issue:10, 2003
Challenges and complexities of alpha-synuclein toxicity: new postulates in unfolding the mystery associated with Parkinson's disease.Archives of biochemistry and biophysics, , Oct-15, Volume: 418, Issue:2, 2003
Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer's and Parkinson's diseases.Neuromolecular medicine, , Volume: 4, Issue:1-2, 2003
[Lewy bodies, a misleading marker for Parkinson's disease?].Bulletin de l'Academie nationale de medecine, , Volume: 187, Issue:2, 2003
Aggregation of alpha-synuclein in the pathogenesis of Parkinson's disease.Journal of neurology, , Volume: 250 Suppl 3, 2003
New insights into Parkinson's disease.Journal of neurology, , Volume: 250 Suppl 3, 2003
NACP-REP1 polymorphism is not involved in Parkinson's disease: a case-control study in a population sample from southern Italy.Neuroscience letters, , Nov-13, Volume: 351, Issue:2, 2003
Molecular pathways of neurodegeneration in Parkinson's disease.Science (New York, N.Y.), , Oct-31, Volume: 302, Issue:5646, 2003
alpha-Synuclein locus triplication causes Parkinson's disease.Science (New York, N.Y.), , Oct-31, Volume: 302, Issue:5646, 2003
Case-control study of the alpha-synuclein interacting protein gene and Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 18, Issue:11, 2003
Caught in the act: alpha-synuclein is the culprit in Parkinson's disease.Neuron, , Oct-30, Volume: 40, Issue:3, 2003
Alpha-synuclein gene triplication discovered in Parkinson's disease.The Lancet. Neurology, , Volume: 2, Issue:12, 2003
[Study on exons 3 and 4 of alpha-synuclein gene in Chinese familial Parkinson disease patients].Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, , Volume: 20, Issue:6, 2003
Degenerative axonal changes in the hippocampus and amygdala in Parkinson's disease.Folia neuropathologica, , Volume: 41, Issue:4, 2003
Regulation of alpha-synuclein expression: implications for Parkinson's disease.Cold Spring Harbor symposia on quantitative biology, , Volume: 68, 2003
Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alpha-synuclein.The Journal of biological chemistry, , Feb-22, Volume: 277, Issue:8, 2002
Effects of pharmacological agents upon a transgenic model of Parkinson's disease in Drosophila melanogaster.The Journal of pharmacology and experimental therapeutics, , Volume: 300, Issue:1, 2002
The reaction of nitric oxide with 6-hydroxydopamine: implications for Parkinson's disease.Free radical biology & medicine, , Jan-15, Volume: 32, Issue:2, 2002
Alzheimer's and Parkinson's disease--overlapping or synergistic pathologies?Trends in molecular medicine, , Volume: 8, Issue:1, 2002
No male predominance in alpha-synuclein Parkinson's disease but the affected female fetus might be less viable.Journal of neurology, neurosurgery, and psychiatry, , Volume: 72, Issue:2, 2002
Recent advances in the genetics and pathogenesis of Parkinson disease.Neurology, , Jan-22, Volume: 58, Issue:2, 2002
Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein.Journal of molecular biology, , Jan-25, Volume: 315, Issue:4, 2002
Heparin and other glycosaminoglycans stimulate the formation of amyloid fibrils from alpha-synuclein in vitro.Biochemistry, , Feb-05, Volume: 41, Issue:5, 2002
Overexpression of human alpha-synuclein causes dopamine neuron death in primary human mesencephalic culture.Brain research, , Feb-01, Volume: 926, Issue:1-2, 2002
Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease.Science (New York, N.Y.), , Feb-01, Volume: 295, Issue:5556, 2002
Iron and Parkinson's disease.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, , Volume: 8, Issue:1, 2002
Human alpha-synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine.Neuroscience letters, , Mar-08, Volume: 320, Issue:3, 2002
14-3-3 proteins in Lewy bodies in Parkinson disease and diffuse Lewy body disease brains.Journal of neuropathology and experimental neurology, , Volume: 61, Issue:3, 2002
Molecular crowding accelerates fibrillization of alpha-synuclein: could an increase in the cytoplasmic protein concentration induce Parkinson's disease?Biochemistry, , Mar-26, Volume: 41, Issue:12, 2002
Dopaminergic cell loss induced by human A30P alpha-synuclein gene transfer to the rat substantia nigra.Human gene therapy, , Mar-20, Volume: 13, Issue:5, 2002
Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Apr-01, Volume: 22, Issue:7, 2002
Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism.Biochemistry, , Apr-09, Volume: 41, Issue:14, 2002
Co-occurrence of Parkinson's disease with progressive supranuclear palsy.Acta neuropathologica, , Volume: 103, Issue:5, 2002
Accelerated alpha-synuclein fibrillation in crowded milieu.FEBS letters, , Mar-27, Volume: 515, Issue:1-3, 2002
A role for alpha-synuclein in the regulation of dopamine biosynthesis.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Apr-15, Volume: 22, Issue:8, 2002
Sequence conservation between mouse and human synphilin-1.Neuroscience letters, , Mar-29, Volume: 322, Issue:1, 2002
6-Hydroxydopamine lesioning differentially affects alpha-synuclein mRNA expression in the nucleus accumbens, striatum and substantia nigra of adult rats.Neuroscience letters, , Mar-29, Volume: 322, Issue:1, 2002
Aggregation of alpha-synuclein induced by the Cu,Zn-superoxide dismutase and hydrogen peroxide system.Free radical biology & medicine, , Mar-15, Volume: 32, Issue:6, 2002
An alternatively spliced form of rodent alpha-synuclein forms intracellular inclusions in vitro: role of the carboxy-terminus in alpha-synuclein aggregation.Neuroscience letters, , May-03, Volume: 323, Issue:3, 2002
Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice.Experimental neurology, , Volume: 175, Issue:1, 2002
The cell biology of alpha-synuclein: a sticky problem?Neuromolecular medicine, , Volume: 1, Issue:2, 2002
Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease.Free radical biology & medicine, , Jun-01, Volume: 32, Issue:11, 2002
Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease.Nature medicine, , Volume: 8, Issue:6, 2002
Mutant and wild-type alpha-synuclein interact with mitochondrial cytochrome C oxidase.Journal of molecular neuroscience : MN, , Volume: 18, Issue:3, 2002
MPP+ increases alpha-synuclein expression and ERK/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cells.Brain research, , May-10, Volume: 935, Issue:1-2, 2002
Parkinson's disease: one biochemical pathway to fit all genes?Trends in molecular medicine, , Volume: 8, Issue:5, 2002
Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred.Acta neuropathologica, , Volume: 104, Issue:1, 2002
Genetics of Parkinson's disease and biochemical studies of implicated gene products.Current opinion in genetics & development, , Volume: 12, Issue:3, 2002
Structural transformation and aggregation of human alpha-synuclein in trifluoroethanol: non-amyloid component sequence is essential and beta-sheet formation is prerequisite to aggregation.Biopolymers, , Aug-05, Volume: 64, Issue:4, 2002
alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , Aug-06, Volume: 99, Issue:16, 2002
Neurodegenerative disease: amyloid pores from pathogenic mutations.Nature, , Jul-18, Volume: 418, Issue:6895, 2002
[Parkin, alpha-synuclein and other molecular aspects of Parkinson's disease].Journal de la Societe de biologie, , Volume: 196, Issue:1, 2002
Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line.The Journal of biological chemistry, , Oct-11, Volume: 277, Issue:41, 2002
Structure/function of alpha-synuclein in health and disease: rational development of animal models for Parkinson's and related diseases.Journal of neurochemistry, , Volume: 82, Issue:3, 2002
Clusterin/apolipoprotein J is associated with cortical Lewy bodies: immunohistochemical study in cases with alpha-synucleinopathies.Acta neuropathologica, , Volume: 104, Issue:3, 2002
An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Aug-15, Volume: 22, Issue:16, 2002
Meta-analysis of alpha synuclein/ NACP polymorphism in Parkinson's disease in Japan.Journal of neurology, neurosurgery, and psychiatry, , Volume: 73, Issue:3, 2002
Genetics of parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Volume: 17, Issue:4, 2002
Survival duration of Parkinson's disease patients living in Greece who carry the G209A alpha-synuclein mutation.Movement disorders : official journal of the Movement Disorder Society, , Volume: 17, Issue:4, 2002
Nonselenium glutathione peroxidase in human brain : elevated levels in Parkinson's disease and dementia with lewy bodies.The American journal of pathology, , Volume: 161, Issue:3, 2002
Molecular genetic analysis of the alpha-synuclein and the parkin gene in Parkinson's disease in Finland.European journal of neurology, , Volume: 9, Issue:5, 2002
Genetics of Parkinson's disease and biochemical studies of implicated gene products.Current opinion in cell biology, , Volume: 14, Issue:5, 2002
Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease.Human molecular genetics, , Oct-01, Volume: 11, Issue:20, 2002
A novel polymorphic triplet repeat in intron five of the alpha-synuclein gene: no evidence of expansion or allelic association with idiopathic Parkinson's disease in the Irish.Neuroreport, , Sep-16, Volume: 13, Issue:13, 2002
Overexpression of Parkinson's disease-associated alpha-synucleinA53T by recombinant adeno-associated virus in mice does not increase the vulnerability of dopaminergic neurons to MPTP.Journal of neurobiology, , Volume: 53, Issue:1, 2002
Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils.Journal of molecular biology, , Oct-04, Volume: 322, Issue:5, 2002
Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.Proceedings of the National Academy of Sciences of the United States of America, , Oct-29, Volume: 99, Issue:22, 2002
Clinical correlates of selective pathology in the amygdala of patients with Parkinson's disease.Brain : a journal of neurology, , Volume: 125, Issue:Pt 11, 2002
Alpha-synuclein lowers p53-dependent apoptotic response of neuronal cells. Abolishment by 6-hydroxydopamine and implication for Parkinson's disease.The Journal of biological chemistry, , Dec-27, Volume: 277, Issue:52, 2002
Mechanistic approaches to Parkinson's disease pathogenesis.Brain pathology (Zurich, Switzerland), , Volume: 12, Issue:4, 2002
The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.Cell, , Oct-18, Volume: 111, Issue:2, 2002
Association of Lewy bodies and glial cytoplasmic inclusions in the brain of Parkinson's disease.Acta neuropathologica, , Volume: 104, Issue:5, 2002
Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease.Brain research, , Nov-22, Volume: 956, Issue:1, 2002
Parkinson's disease and related synucleinopathies are a new class of nervous system amyloidoses.Neurotoxicology, , Volume: 23, Issue:4-5, 2002
Synergistic effects of pesticides and metals on the fibrillation of alpha-synuclein: implications for Parkinson's disease.Neurotoxicology, , Volume: 23, Issue:4-5, 2002
Conformational behavior of human alpha-synuclein is modulated by familial Parkinson's disease point mutations A30P and A53T.Neurotoxicology, , Volume: 23, Issue:4-5, 2002
Alpha-synuclein and presynaptic function: implications for Parkinson's disease.Neuromolecular medicine, , Volume: 2, Issue:2, 2002
Platelet alpha- and gamma-synucleins in Parkinson's disease and normal control subjects.Journal of Alzheimer's disease : JAD, , Volume: 4, Issue:4, 2002
[Gene diagnosis of Alzheimer's disease and Parkinson's disease].Rinsho byori. The Japanese journal of clinical pathology, , Volume: 50, Issue:10, 2002
Nicotinic receptors in the putamen of patients with dementia with Lewy bodies and Parkinson's disease: relation to changes in alpha-synuclein expression.Neuroscience letters, , Dec-25, Volume: 335, Issue:2, 2002
Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein.Nature reviews. Neuroscience, , Volume: 3, Issue:12, 2002
Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons.Neuron, , Dec-19, Volume: 36, Issue:6, 2002
[Genetics and environmental factors of Parkinson disease].Revue neurologique, , Volume: 158 Spec no 1, 2002
Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice.Proceedings of the National Academy of Sciences of the United States of America, , Jun-25, Volume: 99, Issue:13, 2002
The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease.Journal of neurochemistry, , Volume: 76, Issue:1, 2001
Synucleinopathies: clinical and pathological implications.Archives of neurology, , Volume: 58, Issue:2, 2001
Genetic studies in Parkinson's disease with an alpha-synuclein/NACP gene polymorphism in Japan.Neuroscience letters, , Mar-09, Volume: 300, Issue:2, 2001
Mutations in the alpha-synuclein gene in Parkinson's disease among Indians.Acta neurologica Scandinavica, , Volume: 103, Issue:2, 2001
alpha-Synuclein forms a complex with transcription factor Elk-1.Journal of neurochemistry, , Volume: 77, Issue:1, 2001
Conformational properties of alpha-synuclein in its free and lipid-associated states.Journal of molecular biology, , Apr-06, Volume: 307, Issue:4, 2001
alpha-synuclein immunopositive Parkinson's disease-related inclusion bodies in lower brain stem nuclei.Acta neuropathologica, , Volume: 101, Issue:3, 2001
Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis.Human molecular genetics, , Apr-15, Volume: 10, Issue:9, 2001
Clinical phenotype in patients with alpha-synuclein Parkinson's disease living in Greece in comparison with patients with sporadic Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry, , Volume: 70, Issue:5, 2001
Fate of midbrain dopaminergic neurons controlled by the engrailed genes.The Journal of neuroscience : the official journal of the Society for Neuroscience, , May-01, Volume: 21, Issue:9, 2001
Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations.Journal of neurochemistry, , Volume: 77, Issue:3, 2001
Parkinson's disease is not associated with the combined alpha-synuclein/apolipoprotein E susceptibility genotype.Annals of neurology, , Volume: 49, Issue:5, 2001
Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice.Journal of neurochemistry, , Volume: 77, Issue:4, 2001
alpha-Synuclein implicated in Parkinson's disease catalyses the formation of hydrogen peroxide in vitro.Free radical biology & medicine, , May-15, Volume: 30, Issue:10, 2001
Parkinson's disease and other alpha-synucleinopathies.Clinical chemistry and laboratory medicine, , Volume: 39, Issue:4, 2001
Alpha-synuclein. Axonal transport, ligand interaction and neurodegeneration.Advances in experimental medicine and biology, , Volume: 487, 2001
Mouse models of alpha-synucleinopathy and Lewy pathology. Alpha-synuclein expression in transgenic mice.Advances in experimental medicine and biology, , Volume: 487, 2001
Abnormal patterns of microtubule-associated protein-2 (MAP-2) immunolabeling in neuronal nuclei and Lewy bodies in Parkinson's disease substantia nigra brain tissues.Neuroscience letters, , Jun-29, Volume: 306, Issue:3, 2001
[Alpha-synucleinopathies].Neurologia (Barcelona, Spain), , Volume: 16, Issue:4, 2001
Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.Biochemistry, , Jul-03, Volume: 40, Issue:26, 2001
Genetics of Parkinsonism: a review.Annals of human genetics, , Volume: 65, Issue:Pt 2, 2001
Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease.Science (New York, N.Y.), , Jul-13, Volume: 293, Issue:5528, 2001
Alpha-synuclein and neurodegenerative diseases.Nature reviews. Neuroscience, , Volume: 2, Issue:7, 2001
Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons.Neuroscience, , Volume: 104, Issue:3, 2001
Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease.FEBS letters, , Jul-06, Volume: 500, Issue:3, 2001
Decreased platelet glutamate uptake and genetic risk factors in patients with Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 22, Issue:1, 2001
Alpha synuclein aggregation: is it the toxic gain of function responsible for neurodegeneration in Parkinson's disease?Mechanisms of ageing and development, , Sep-30, Volume: 122, Issue:14, 2001
Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells.Journal of neurochemistry, , Volume: 78, Issue:4, 2001
alpha-Synuclein gene haplotypes are associated with Parkinson's disease.Human molecular genetics, , Aug-15, Volume: 10, Issue:17, 2001
Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure.The Journal of biological chemistry, , Nov-23, Volume: 276, Issue:47, 2001
Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein.Biochemistry, , Sep-25, Volume: 40, Issue:38, 2001
beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , Oct-09, Volume: 98, Issue:21, 2001
Evaluation of the gamma-synuclein gene in German Parkinson's disease patients.Neuroscience letters, , Sep-14, Volume: 310, Issue:2-3, 2001
Co-association of parkin and alpha-synuclein.Neuroreport, , Sep-17, Volume: 12, Issue:13, 2001
Residual structure and dynamics in Parkinson's disease-associated mutants of alpha-synuclein.The Journal of biological chemistry, , Dec-07, Volume: 276, Issue:49, 2001
Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease.Nature medicine, , Volume: 7, Issue:10, 2001
The G209A mutation in the alpha-synuclein gene in Brazilian families with Parkinson's disease.Arquivos de neuro-psiquiatria, , Volume: 59, Issue:3-B, 2001
Alpha-synuclein has an altered conformation and shows a tight intermolecular interaction with ubiquitin in Lewy bodies.Acta neuropathologica, , Volume: 102, Issue:4, 2001
Cortical Lewy body pathology in the diagnosis of dementia.Acta neuropathologica, , Volume: 102, Issue:4, 2001
Brain iron pathways and their relevance to Parkinson's disease.Journal of neurochemistry, , Volume: 79, Issue:2, 2001
Widespread occurrence of argyrophilic glial inclusions in Parkinson's disease.Neuropathology and applied neurobiology, , Volume: 27, Issue:5, 2001
Genetics of Parkinson's disease.Journal of neurology, , Volume: 248, Issue:10, 2001
Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct.Science (New York, N.Y.), , Nov-09, Volume: 294, Issue:5545, 2001
Alpha-synuclein in familial Alzheimer disease: epitope mapping parallels dementia with Lewy bodies and Parkinson disease.Archives of neurology, , Volume: 58, Issue:11, 2001
alpha-Synuclein and parkin: coming together of pieces in puzzle of Parkinson's disease.Lancet (London, England), , Nov-10, Volume: 358, Issue:9293, 2001
alpha-synuclein and cytosolic dopamine: stabilizing a bad situation.Nature medicine, , Volume: 7, Issue:12, 2001
Sympathetic neurocirculatory failure in Parkinson disease: Evidence for an etiologic role of alpha-synuclein.Annals of internal medicine, , Dec-04, Volume: 135, Issue:11, 2001
alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome.FEBS letters, , Nov-30, Volume: 509, Issue:1, 2001
Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Dec-15, Volume: 21, Issue:24, 2001
Lack of binding observed between human alpha-synuclein and Bcl-2 protein family.Neuroscience letters, , Volume: 316, Issue:2, 2001
Clinical features of parkinsonian patients with the alpha-synuclein (G209A) mutation.Movement disorders : official journal of the Movement Disorder Society, , Volume: 16, Issue:6, 2001
Analysis of the coding and the 5' flanking regions of the alpha-synuclein gene in patients with Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 16, Issue:6, 2001
Effect of allelic variation at the NACP-Rep1 repeat upstream of the alpha-synuclein gene (SNCA) on transcription in a cell culture luciferase reporter system.Human molecular genetics, , Dec-15, Volume: 10, Issue:26, 2001
Active, phosphorylation-dependent mitogen-activated protein kinase (MAPK/ERK), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and p38 kinase expression in Parkinson's disease and Dementia with Lewy bodies.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 108, Issue:12, 2001
The cellular pathology of Parkinson's disease.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 21, Issue:4, 2001
Production of reactive oxygen species from aggregating proteins implicated in Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases.Current topics in medicinal chemistry, , Volume: 1, Issue:6, 2001
Genetics of movement disorders: an abbreviated overview.Stereotactic and functional neurosurgery, , Volume: 77, Issue:1-4, 2001
Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein.The Journal of biological chemistry, , Jan-07, Volume: 275, Issue:1, 2000
Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy.Proceedings of the National Academy of Sciences of the United States of America, , Jan-18, Volume: 97, Issue:2, 2000
NACP/alpha-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson's disease brains.Acta neuropathologica, , Volume: 99, Issue:1, 2000
Expression of alpha-synuclein, parkin, and ubiquitin carboxy-terminal hydrolase L1 mRNA in human brain: genes associated with familial Parkinson's disease.Annals of neurology, , Volume: 47, Issue:2, 2000
A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease.Journal of neuroscience research, , Feb-15, Volume: 59, Issue:4, 2000
Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid.Biochemistry, , Mar-14, Volume: 39, Issue:10, 2000
Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations.The Journal of biological chemistry, , Mar-24, Volume: 275, Issue:12, 2000
A Drosophila model of Parkinson's disease.Nature, , Mar-23, Volume: 404, Issue:6776, 2000
Synphilin-1 is present in Lewy bodies in Parkinson's disease.Annals of neurology, , Volume: 47, Issue:4, 2000
The alpha-synuclein gene and Parkinson disease in a Chinese population.Archives of neurology, , Volume: 57, Issue:4, 2000
Alpha-synuclein and the Parkinson's disease-related mutant Ala53Thr-alpha-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cells.Neuroscience letters, , May-12, Volume: 285, Issue:2, 2000
Parkinson's disease: affection of brain stem nuclei controlling premotor and motor neurons of the somatomotor system.Acta neuropathologica, , Volume: 99, Issue:5, 2000
Alpha-synuclein and Parkinson's disease: selective neurodegenerative effect of alpha-synuclein fragment on dopaminergic neurons in vitro and in vivo.Annals of neurology, , Volume: 47, Issue:5, 2000
Involvement of alpha-synuclein in Parkinson's disease and other neurodegenerative disorders.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 107, Issue:1, 2000
Wild-type but not Parkinson's disease-related ala-53 --> Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli.The Journal of biological chemistry, , Aug-04, Volume: 275, Issue:31, 2000
Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease.Neurology, , May-23, Volume: 54, Issue:10, 2000
Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells.Brain research, , Jun-02, Volume: 866, Issue:1-2, 2000
Full length alpha-synuclein is present in cerebrospinal fluid from Parkinson's disease and normal subjects.Neuroscience letters, , Jun-16, Volume: 287, Issue:1, 2000
Accumulation of insoluble alpha-synuclein in dementia with Lewy bodies.Neurobiology of disease, , Volume: 7, Issue:3, 2000
Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?Nature cell biology, , Volume: 2, Issue:7, 2000
Properties of NACP/alpha-synuclein and its role in Alzheimer's disease.Biochimica et biophysica acta, , Jul-26, Volume: 1502, Issue:1, 2000
Late-onset neurodegenerative diseases--the role of protein insolubility.Journal of anatomy, , Volume: 196 ( Pt 4), 2000
The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Aug-15, Volume: 20, Issue:16, 2000
Parkinson's disease-associated alpha-synuclein is more fibrillogenic than beta- and gamma-synuclein and cannot cross-seed its homologs.The Journal of biological chemistry, , Nov-03, Volume: 275, Issue:44, 2000
Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.The Journal of biological chemistry, , Nov-03, Volume: 275, Issue:44, 2000
Oxidative stress and genetics in the pathogenesis of Parkinson's disease.Neurobiology of disease, , Volume: 7, Issue:4, 2000
Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Sep-01, Volume: 20, Issue:17, 2000
Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease.Acta neuropathologica, , Volume: 100, Issue:3, 2000
Induction of neuronal death by alpha-synuclein.The European journal of neuroscience, , Volume: 12, Issue:8, 2000
Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein.Biochemistry, , Sep-05, Volume: 39, Issue:35, 2000
Progress in the clinical and molecular genetics of familial parkinsonism.Neurogenetics, , Volume: 2, Issue:4, 2000
Characterisation of isolated alpha-synuclein filaments from substantia nigra of Parkinson's disease brain.Neuroscience letters, , Oct-06, Volume: 292, Issue:2, 2000
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions.Science (New York, N.Y.), , Nov-03, Volume: 290, Issue:5493, 2000
Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity.Human molecular genetics, , Nov-01, Volume: 9, Issue:18, 2000
[Molecular pathogenesis of familial Parkinson's disease].Nihon rinsho. Japanese journal of clinical medicine, , Volume: 58, Issue:10, 2000
[The mechanism of Lewy body formation in Parkinson's disease].Nihon rinsho. Japanese journal of clinical medicine, , Volume: 58, Issue:10, 2000
Activated microglial cells and complement factors are unrelated to cortical Lewy bodies.Acta neuropathologica, , Volume: 100, Issue:6, 2000
Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein.Journal of neurochemistry, , Volume: 75, Issue:6, 2000
In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodies.Experimental neurology, , Volume: 166, Issue:2, 2000
Monoclonal antibodies against Epstein-Barr virus cross-react with alpha-synuclein in human brain.Neurology, , Nov-14, Volume: 55, Issue:9, 2000
[Synucleins--to have or not to have].Genetika, , Volume: 36, Issue:11, 2000
Linkage exclusion in French families with probable Parkinson' s disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 15, Issue:6, 2000
Mouse models of alpha-synucleinopathy and Lewy pathology.Experimental gerontology, , Volume: 35, Issue:9-10, 2000
The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.Annals of the New York Academy of Sciences, , Volume: 920, 2000
Genetics of Parkinson's disease.Annals of the New York Academy of Sciences, , Volume: 920, 2000
Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein.Annals of the New York Academy of Sciences, , Volume: 920, 2000
Accelerated oligomerization by Parkinson's disease linked alpha-synuclein mutants.Annals of the New York Academy of Sciences, , Volume: 920, 2000
Importance of familial Parkinson's disease and parkinsonism to the understanding of nigral degeneration in sporadic Parkinson's disease.Journal of neural transmission. Supplementum, , Issue:60, 2000
Depression in alpha-synucleinopathies: prevalence, pathophysiology and treatment.Journal of neural transmission. Supplementum, , Issue:60, 2000
Structural changes in alpha-synuclein affect its chaperone-like activity in vitro.Protein science : a publication of the Protein Society, , Volume: 9, Issue:12, 2000
Alpha-synuclein is not a requisite component of synaptic boutons in the adult human central nervous system.Journal of chemical neuroanatomy, , Volume: 20, Issue:3-4, 2000
Crosslinking of alpha-synuclein by advanced glycation endproducts--an early pathophysiological step in Lewy body formation?Journal of chemical neuroanatomy, , Volume: 20, Issue:3-4, 2000
Alpha-synuclein and Parkinson's disease.Cellular and molecular life sciences : CMLS, , Volume: 57, Issue:13-14, 2000
Alpha-synuclein and Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 14, Issue:1, 1999
No mutation of G209A in the alpha-synuclein gene in sporadic Parkinson's disease among Taiwan Chinese.European neurology, , Volume: 41, Issue:2, 1999
Mutated alpha-synuclein gene in two Greek kindreds with familial PD: incomplete penetrance?Neurology, , Volume: 52, Issue:3, 1999
Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro.The Journal of biological chemistry, , Mar-19, Volume: 274, Issue:12, 1999
Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation.The Journal of biological chemistry, , Apr-02, Volume: 274, Issue:14, 1999
Synoretin--A new protein belonging to the synuclein family.Molecular and cellular neurosciences, , Volume: 13, Issue:2, 1999
Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions.Nature genetics, , Volume: 22, Issue:1, 1999
Increased susceptibility to sporadic Parkinson's disease by a certain combined alpha-synuclein/apolipoprotein E genotype.Annals of neurology, , Volume: 45, Issue:5, 1999
Extensive axonal Lewy neurites in Parkinson's disease: a novel pathological feature revealed by alpha-synuclein immunocytochemistry.Neuroscience letters, , Apr-09, Volume: 265, Issue:1, 1999
Numerous and widespread alpha-synuclein-negative Lewy bodies in an asymptomatic patient.Acta neuropathologica, , Volume: 97, Issue:5, 1999
Alpha-synuclein expression in substantia nigra and cortex in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 14, Issue:3, 1999
Genetics of Parkinson's disease.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 53, Issue:3, 1999
Copper(II)-induced self-oligomerization of alpha-synuclein.The Biochemical journal, , Jun-15, Volume: 340 ( Pt 3), 1999
alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease.The Journal of biological chemistry, , Jul-09, Volume: 274, Issue:28, 1999
Genetic analysis of families with Parkinson disease that carry the Ala53Thr mutation in the gene encoding alpha-synuclein.American journal of human genetics, , Volume: 65, Issue:2, 1999
[alpha-Synuclein and familial Parkinson's disease].No to shinkei = Brain and nerve, , Volume: 51, Issue:6, 1999
No pathogenic mutations in the beta-synuclein gene in Parkinson's disease.Neuroscience letters, , Jul-09, Volume: 269, Issue:2, 1999
Filamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and alpha-synucleinopathies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences, , Jun-29, Volume: 354, Issue:1386, 1999
Alpha-synuclein accumulates in Lewy bodies in Parkinson's disease and dementia with Lewy bodies but not in Alzheimer's disease beta-amyloid plaque cores.Neuroscience letters, , May-14, Volume: 266, Issue:3, 1999
[Genetics of Parkinson disease].La Revue de medecine interne, , Volume: 20, Issue:8, 1999
Reduced expression of the G209A alpha-synuclein allele in familial Parkinsonism.Annals of neurology, , Volume: 46, Issue:3, 1999
Synucleins in synaptic plasticity and neurodegenerative disorders.Journal of neuroscience research, , Oct-01, Volume: 58, Issue:1, 1999
Cellular co-localization of phosphorylated tau- and NACP/alpha-synuclein-epitopes in lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies.Brain research, , Oct-02, Volume: 843, Issue:1-2, 1999
The alpha-synuclein gene is not a major risk factor in familial Parkinson disease.Neurogenetics, , Volume: 2, Issue:3, 1999
Alpha-synuclein immunoreactive Lewy bodies and Lewy neurites in Parkinson's disease are detectable by an advanced silver-staining technique.Acta neuropathologica, , Volume: 98, Issue:5, 1999
Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , Nov-09, Volume: 96, Issue:23, 1999
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Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.The Journal of biological chemistry, , Oct-09, Volume: 273, Issue:41, 1998
Abnormal distribution of the non-Abeta component of Alzheimer's disease amyloid precursor/alpha-synuclein in Lewy body disease as revealed by proteinase K and formic acid pretreatment.Laboratory investigation; a journal of technical methods and pathology, , Volume: 78, Issue:9, 1998
Genetic dissection of familial Parkinson's disease.Molecular medicine today, , Volume: 4, Issue:10, 1998
Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.Nature medicine, , Volume: 4, Issue:11, 1998
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Lack of mutation G209A in the alpha-synuclein gene in French patients with familial and sporadic Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry, , Volume: 65, Issue:6, 1998
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Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments.FEBS letters, , Nov-27, Volume: 440, Issue:1-2, 1998
The G209A mutation in the alpha-synuclein gene is not detected in familial cases of Parkinson disease in non-Greek and/or Italian populations.Archives of neurology, , Volume: 55, Issue:12, 1998
Degenerative terminals of the perforant pathway are human alpha-synuclein-immunoreactive in the hippocampus of patients with diffuse Lewy body disease.Neuroscience letters, , Dec-18, Volume: 258, Issue:2, 1998
Mutation screening in exons 3 and 4 of alpha-synuclein in sporadic Parkinson's and sporadic and familial dementia with Lewy bodies cases.Neuroreport, , Dec-01, Volume: 9, Issue:17, 1998
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SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures.eNeuro, , Volume: 8, Issue:4
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Gene Therapy for Parkinson's Disease Associated with GBA1 Mutations.Journal of Parkinson's disease, , Volume: 11, Issue:s2
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[Frequency of the IVS4+66A-G polymorphism in the alpha-synuclein gene in patients with Parkinson's disease in north-western Mexico].Revista de neurologia, , Volume: 44, Issue:1
Templated α-Synuclein Inclusion Formation Is Independent of Endogenous Tau.eNeuro, , Volume: 8, Issue:3
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Genetic deletion of Polo-like kinase 2 reduces alpha-synuclein serine-129 phosphorylation in presynaptic terminals but not Lewy bodies.The Journal of biological chemistry, , Volume: 296
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What's to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?Prion, , Volume: 7, Issue:1
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Development of a new treatment for Alzheimer's disease and Parkinson's disease using anti-aggregatory beta-synuclein-derived peptides.Journal of molecular neuroscience : MN, , Volume: 19, Issue:1-2
The SUMO Conjugase Ubc9 Protects Dopaminergic Cells from Cytotoxicity and Enhances the Stability of α-Synuclein in Parkinson's Disease Models.eNeuro, , Volume: 7, Issue:5
A review on the cause-effect relationship between oxidative stress and toxic proteins in the pathogenesis of neurodegenerative diseases.Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, , Volume: 118, Issue:1
Motor dysfunction and gliosis with preserved dopaminergic markers in human alpha-synuclein A30P transgenic mice.Neurobiology of aging, , Volume: 24, Issue:2
Developmental Changes in Dendritic Spine Morphology in the Striatum and Their Alteration in an A53T α-Synuclein Transgenic Mouse Model of Parkinson's Disease.eNeuro, , Volume: 7, Issue:4
Molecular analysis of α-synuclein gene in Parkinson's disease in North Karnataka, India.Neurology India, , Volume: 62, Issue:2
[no title available]eNeuro, , Volume: 7, Issue:4
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Clinical Neuropathology image 5-2014: α-synuclein pathology in the ependyma in Parkinson's disease.Clinical neuropathology, , Volume: 33, Issue:5
Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons.eNeuro, , Volume: 4, Issue:2
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Alpha-synuclein Levels in the Differential Diagnosis of Lewy Bodies Dementia and Other Neurodegenerative Disorders: A Meta-analysis.Alzheimer disease and associated disorders, , Volume: 34, Issue:3
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Nonclinical safety evaluation, pharmacokinetics, and target engagement of Lu AF82422, a monoclonal IgG1 antibody against alpha-synuclein in development for treatment of synucleinopathies.mAbs, , Volume: 13, Issue:1
The effect of macromolecular crowding on protein aggregation and amyloid fibril formation.Journal of molecular recognition : JMR, , Volume: 17, Issue:5
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Locus Coeruleus Pathology Indicates a Continuum of Lewy Body Dementia.Journal of Parkinson's disease, , Volume: 11, Issue:4
Abeta deposition is associated with enhanced cortical alpha-synuclein lesions in Lewy body diseases.Neurobiology of aging, , Volume: 26, Issue:8
Long-Term Exposure to PFE-360 in the AAV-α-Synuclein Rat Model: Findings and Implications.eNeuro, , Volume: 6, Issue:6
A Summary of Phenotypes Observed in the In Vivo Rodent Alpha-Synuclein Preformed Fibril Model.Journal of Parkinson's disease, , Volume: 11, Issue:4
Immune repertoire mining for rapid affinity optimization of mouse monoclonal antibodies.mAbs, , Volume: 11, Issue:4
Alpha-synuclein-based models of Parkinson's disease.Revue neurologique, , Volume: 172, Issue:6-7
Multivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates.mAbs, , Volume: 15, Issue:1
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[The processes of α-synuclein amyloid protein complexes involved in the pathogenesis of Parkinson's disease].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, , Volume: 118, Issue:8
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[Mitochondrial dysfunction and oxidative damages in the molecular pathology of Parkinson's disease].Molekuliarnaia biologiia, , Volume: 42, Issue:5
Immunology of West Nile Virus Infection and the Role of Alpha-Synuclein as a Viral Restriction Factor.Viral immunology, , Volume: 32, Issue:1
(123)I-FP-CIT SPET striatal uptake in parkinsonian patients with the alpha-synuclein (G209A) mutation A.Hellenic journal of nuclear medicine, , Volume: 11, Issue:3
[Lewy bodies in Parkinson's disease: histological, immunohistochemical, and interferometric examinations].Arkhiv patologii, , Volume: 80, Issue:4
Cognitive and neuropsychiatric profile of the synucleinopathies: Parkinson disease, dementia with Lewy bodies, and multiple system atrophy.Alzheimer disease and associated disorders, , Volume: 23, Issue:4
Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models.Disease models & mechanisms, , Volume: 3, Issue:3-4
[Parkinson's disease dementia: correlations between clinical, neuropsychological and neuropathological features].Revue neurologique, , Volume: 166, Issue:6-7
Preventing Parkinson's pathology.Disease models & mechanisms, , Volume: 3, Issue:7-8
Protective Effects of Ursodeoxycholic Acid Against Oxidative Stress and Neuroinflammation Through Mitogen-Activated Protein Kinases Pathway in MPTP-Induced Parkinson Disease.Clinical neuropharmacology, , Volume: 45, Issue:6
Alpha-synuclein stimulation of astrocytes: Potential role for neuroinflammation and neuroprotection.Oxidative medicine and cellular longevity, , Volume: 3, Issue:4
Manganese and related neurotoxic pathways: A potential therapeutic target in neurodegenerative diseases.Neurotoxicology and teratology, , Volume: 94
Evaluation of the α-synuclein PET radiotracer (dNuclear medicine and biology, , Volume: 114-115
The new line of genetically modified mice with constitutive knockout of the gene alpha synuclein to study pathogenetic aspects of differential loss of dopaminergic neurons .Patologicheskaia fiziologiia i eksperimental'naia terapiia, , Volume: 60, Issue:3
Alpha-synuclein in the cerebrospinal fluid differentiates synucleinopathies (Parkinson Disease, dementia with Lewy bodies, multiple system atrophy) from Alzheimer disease.Alzheimer disease and associated disorders, , Volume: 26, Issue:3
α-Synuclein-Dependent Calcium Entry Underlies Differential Sensitivity of Cultured SN and VTA Dopaminergic Neurons to a Parkinsonian Neurotoxin.eNeuro, , Volume: 4, Issue:6
Two hundred steps.Nature, , 10-27, Volume: 538, Issue:7626, 2016
Absence of alpha-synuclein pathology in postencephalitic parkinsonism.Acta neuropathologica, , Volume: 118, Issue:3, 2009
Alpha-synuclein studies are negative in postencephalic parkinsonism of von Economo.Neurology, , Aug-27, Volume: 59, Issue:4, 2002
Xanthotoxin modulates oxidative stress, inflammation, and MAPK signaling in a rotenone-induced Parkinson's disease model.Life sciences, , Dec-01, Volume: 310, 2022
Neuroprotective effects of indole-3-carbinol on the rotenone rat model of Parkinson's disease: Impact of the SIRT1-AMPK signaling pathway.Toxicology and applied pharmacology, , 01-15, Volume: 435, 2022
Cycad Genotoxin Methylazoxymethanol Disrupts the Brain Ubiquitin-Proteasome Pathway, Tau and α-Synuclein, as Reported in ALS-PDC.Journal of neuropathology and experimental neurology, , 02-22, Volume: 80, Issue:3, 2021
Metals associated neurodegeneration in Parkinson's disease: Insight to physiological, pathological mechanisms and management.Neuroscience letters, , 05-14, Volume: 753, 2021
Benzo(a)pyrene exposure in utero exacerbates Parkinson's Disease (PD)-like α-synucleinopathy in A53T human alpha-synuclein transgenic mice.Toxicology and applied pharmacology, , 09-15, Volume: 427, 2021
Parkinson-like early autonomic dysfunction induced by vagal application of DOPAL in rats.CNS neuroscience & therapeutics, , Volume: 27, Issue:5, 2021
An extended release GLP-1 analogue increases α-synuclein accumulation in a mouse model of prodromal Parkinson's disease.Experimental neurology, , Volume: 341, 2021
Administration of quercetin improves mitochondria quality control and protects the neurons in 6-OHDA-lesioned Parkinson's disease models.Aging, , 04-20, Volume: 13, Issue:8, 2021
Noscapine Prevents Rotenone-Induced Neurotoxicity: Involvement of Oxidative Stress, Neuroinflammation and Autophagy Pathways.Molecules (Basel, Switzerland), , Jul-30, Volume: 26, Issue:15, 2021
Autophagy-dependent removal of α-synuclein: a novel mechanism of GM1 ganglioside neuroprotection against Parkinson's disease.Acta pharmacologica Sinica, , Volume: 42, Issue:4, 2021
Protective effect of plastrum testudinis extract on dopaminergic neurons in a Parkinson's disease model through DNMT1 nuclear translocation and SNCA's methylation.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 141, 2021
In Vivo Diagnosis of Synucleinopathies: A Comparative Study of Skin Biopsy and RT-QuIC.Neurology, , 05-18, Volume: 96, Issue:20, 2021
Regular Aerobic Exercise-Alleviated Dysregulation of CAMKIIα Carbonylation to Mitigate Parkinsonism via Homeostasis of Apoptosis With Autophagy.Journal of neuropathology and experimental neurology, , 01-01, Volume: 79, Issue:1, 2020
Neuroprotective effects of Bacopa monnieri in Parkinson's disease model.Metabolic brain disease, , Volume: 35, Issue:3, 2020
Potential therapeutic role of fibroblast growth factor 21 in neurodegeneration: Evidence for ameliorating parkinsonism via silent information regulator 2 homolog 1 and implication for gene therapy.Neuropharmacology, , 12-15, Volume: 181, 2020
Nose to brain delivery of rotigotine loaded chitosan nanoparticles in human SH-SY5Y neuroblastoma cells and animal model of Parkinson's disease.International journal of pharmaceutics, , Apr-15, Volume: 579, 2020
Induction of Autophagy by Vasicinone Protects Neural Cells from Mitochondrial Dysfunction and Attenuates Paraquat-Mediated Parkinson's Disease Associated α-Synuclein Levels.Nutrients, , Jun-07, Volume: 12, Issue:6, 2020
4E-BP1 Protects Neurons from Misfolded Protein Stress and Parkinson's Disease Toxicity by Inducing the Mitochondrial Unfolded Protein Response.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 11-04, Volume: 40, Issue:45, 2020
Dopaminergic neuron injury in Parkinson's disease is mitigated by interfering lncRNA SNHG14 expression to regulate the miR-133b/ α-synuclein pathway.Aging, , 11-04, Volume: 11, Issue:21, 2019
TLR4 deficiency has a protective effect in the MPTP/probenecid mouse model of Parkinson's disease.Acta pharmacologica Sinica, , Volume: 40, Issue:12, 2019
Methyl jasmonate abrogates rotenone-induced parkinsonian-like symptoms through inhibition of oxidative stress, release of pro-inflammatory cytokines, and down-regulation of immnopositive cells of NF-κB and α-synuclein expressions in mice.Neurotoxicology, , Volume: 74, 2019
FTY720 Improves Behavior, Increases Brain Derived Neurotrophic Factor Levels and Reduces α-Synuclein Pathology in Parkinsonian GM2+/- Mice.Neuroscience, , 07-15, Volume: 411, 2019
Administration of resveratrol improved Parkinson's disease-like phenotype by suppressing apoptosis of neurons via modulating the MALAT1/miR-129/SNCA signaling pathway.Journal of cellular biochemistry, , Volume: 120, Issue:4, 2019
NLRP3 inflammasome pathway is involved in olfactory bulb pathological alteration induced by MPTP.Acta pharmacologica Sinica, , Volume: 40, Issue:8, 2019
Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein.Science signaling, , 03-12, Volume: 12, Issue:572, 2019
Acrolein-mediated alpha-synuclein pathology involvement in the early post-injury pathogenesis of mild blast-induced Parkinsonian neurodegeneration.Molecular and cellular neurosciences, , Volume: 98, 2019
Identification of miRNA-7 as a regulator of brain-derived neurotrophic factor/α-synuclein axis in atrazine-induced Parkinson's disease by peripheral blood and brain microRNA profiling.Chemosphere, , Volume: 233, 2019
Hinokitiol Offers Neuroprotection Against 6-OHDA-Induced Toxicity in SH-SY5Y Neuroblastoma Cells by Downregulating mRNA Expression of MAO/α-Synuclein/LRRK2/PARK7/PINK1/PTEN Genes.Neurotoxicity research, , Volume: 35, Issue:4, 2019
Fingolimod (FTY720) is not protective in the subacute MPTP mouse model of Parkinson's disease and does not lead to a sustainable increase of brain-derived neurotrophic factor.Journal of neurochemistry, , Volume: 147, Issue:5, 2018
Glycyrrhizic Acid Alleviates 6-Hydroxydopamine and Corticosterone-Induced Neurotoxicity in SH-SY5Y Cells Through Modulating Autophagy.Neurochemical research, , Volume: 43, Issue:10, 2018
Environmental neurotoxicant manganese regulates exosome-mediated extracellular miRNAs in cell culture model of Parkinson's disease: Relevance to α-synuclein misfolding in metal neurotoxicity.Neurotoxicology, , Volume: 64, 2018
Taurine protects dopaminergic neurons in a mouse Parkinson's disease model through inhibition of microglial M1 polarization.Cell death & disease, , 04-01, Volume: 9, Issue:4, 2018
Alpha-synuclein aggregation, Ubiquitin proteasome system impairment, and L-Dopa response in zinc-induced Parkinsonism: resemblance to sporadic Parkinson's disease.Molecular and cellular biochemistry, , Volume: 444, Issue:1-2, 2018
Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein.Nature communications, , 02-26, Volume: 9, Issue:1, 2018
Increased Oxidative Stress Exacerbates α-Synuclein Aggregation In Vivo.Journal of neuropathology and experimental neurology, , 06-01, Volume: 77, Issue:6, 2018
NLRP3 inflammasome activation in the thymus of MPTP-induced Parkinsonian mouse model.Toxicology letters, , May-15, Volume: 288, 2018
The use of nonhuman primate models to understand processes in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 125, Issue:3, 2018
DL‑3‑n‑butylphthalide reduces microglial activation in lipopolysaccharide‑induced Parkinson's disease model mice.Molecular medicine reports, , Volume: 17, Issue:3, 2018
Decreased expression of serum- and glucocorticoid-inducible kinase 1 (SGK1) promotes alpha-synuclein increase related with down-regulation of dopaminergic cell in the Substantia Nigra of chronic MPTP-induced Parkinsonism mice and in SH-SY5Y cells.Gene, , Jun-30, Volume: 661, 2018
Pramipexole induced place preference after L-dopa therapy and nigral dopaminergic loss: linking behavior to transcriptional modifications.Psychopharmacology, , Volume: 234, Issue:1, 2017
Rifampicin pre-treatment inhibits the toxicity of rotenone-induced PC12 cells by enhancing sumoylation modification of α-synuclein.Biochemical and biophysical research communications, , 03-25, Volume: 485, Issue:1, 2017
Immunomorphological Changes in the Olfactory Bulbs of Rats after Intranasal Administration of Rotenone.Bulletin of experimental biology and medicine, , Volume: 164, Issue:2, 2017
Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson's disease.Experimental neurology, , Volume: 295, 2017
Mitochondrial division inhibitor-1 is neuroprotective in the A53T-α-synuclein rat model of Parkinson's disease.Scientific reports, , 08-08, Volume: 7, Issue:1, 2017
Novel animal model defines genetic contributions for neuron-to-neuron transfer of α-synuclein.Scientific reports, , 08-08, Volume: 7, Issue:1, 2017
S-nitrosylation of UCHL1 induces its structural instability and promotes α-synuclein aggregation.Scientific reports, , 03-16, Volume: 7, 2017
Protective effects and mechanisms of Ndfipl on SH-SY5Y cell apoptosis in an in vitro Parkinson's disease model.Genetics and molecular research : GMR, , Apr-25, Volume: 15, Issue:2, 2016
Neuroprotective Effects of A Standardized Flavonoid Extract of Safflower Against Neurotoxin-Induced Cellular and Animal Models of Parkinson's Disease.Scientific reports, , Feb-24, Volume: 6, 2016
Baicalein inhibits α-synuclein oligomer formation and prevents progression of α-synuclein accumulation in a rotenone mouse model of Parkinson's disease.Biochimica et biophysica acta, , Volume: 1862, Issue:10, 2016
Resveratrol alleviates MPTP-induced motor impairments and pathological changes by autophagic degradation of α-synuclein via SIRT1-deacetylated LC3.Molecular nutrition & food research, , Volume: 60, Issue:10, 2016
Melanin and neuromelanin binding of drugs and chemicals: toxicological implications.Archives of toxicology, , Volume: 90, Issue:8, 2016
Apocyanin, NADPH oxidase inhibitor prevents lipopolysaccharide induced α-synuclein aggregation and ameliorates motor function deficits in rats: Possible role of biochemical and inflammatory alterations.Behavioural brain research, , Jan-01, Volume: 296, 2016
Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice.Antioxidants & redox signaling, , Aug-20, Volume: 23, Issue:6, 2015
Fractalkine over expression suppresses α-synuclein-mediated neurodegeneration.Molecular therapy : the journal of the American Society of Gene Therapy, , Volume: 23, Issue:1, 2015
The Progressive BSSG Rat Model of Parkinson's: Recapitulating Multiple Key Features of the Human Disease.PloS one, , Volume: 10, Issue:10, 2015
Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation.Molecular and cellular biology, , Volume: 35, Issue:16, 2015
Linking microtubules to Parkinson's disease: the case of parkin.Biochemical Society transactions, , Volume: 43, Issue:2, 2015
Proteasome subunit and opioid receptor gene expression down-regulation induced by paraquat and maneb in human neuroblastoma SH-SY5Y cells.Environmental toxicology and pharmacology, , Volume: 40, Issue:3, 2015
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Cell-based assays for Parkinson's disease using differentiated human LUHMES cells.Acta pharmacologica Sinica, , Volume: 35, Issue:7, 2014
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TFEB regulates cellular labile iron and prevents ferroptosis in a TfR1-dependent manner.Free radical biology & medicine, , 11-01, Volume: 208, 2023
l-3,4-dihydroxyphenylalanine (l-DOPA) modulates brain iron, dopaminergic neurodegeneration and motor dysfunction in iron overload and mutant alpha-synuclein mouse models of Parkinson's disease.Journal of neurochemistry, , Volume: 150, Issue:1, 2019
GRK2-Targeted Knockdown as Therapy for Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:7, 2023
The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson's disease.Acta neuropathologica communications, , 05-03, Volume: 11, Issue:1, 2023
Late-onset MSA differs from younger-onset MSA.Journal of neurology, neurosurgery, and psychiatry, , Volume: 94, Issue:7, 2023
Early and extensive alterations of glial connexins, distal oligodendrogliopathy type demyelination, and nodal/paranodal pathology are characteristic of multiple system atrophy.Brain pathology (Zurich, Switzerland), , Volume: 33, Issue:3, 2023
Cancer in pathologically confirmed multiple system atrophy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 33, Issue:4, 2023
Propagative α-synuclein seeds as serum biomarkers for synucleinopathies.Nature medicine, , Volume: 29, Issue:6, 2023
Truncation or proteolysis of α-synuclein in Parkinsonism.Ageing research reviews, , Volume: 90, 2023
Cellular processing of α-synuclein fibrils results in distinct physiological C-terminal truncations with a major cleavage site at residue Glu 114.The Journal of biological chemistry, , Volume: 299, Issue:7, 2023
Generation of TWO G51D SNCA missense mutation iPSC lines (CRICKi011-A, CRICKi012-A) from two individuals at risk of Parkinson's disease.Stem cell research, , Volume: 71, 2023
Disease-Specific α-Synuclein Seeding in Lewy Body Disease and Multiple System Atrophy Are Preserved in Formaldehyde-Fixed Paraffin-Embedded Human Brain.Biomolecules, , 06-02, Volume: 13, Issue:6, 2023
Evaluation of α-synuclein in CNS-originating extracellular vesicles for Parkinsonian disorders: A systematic review and meta-analysis.CNS neuroscience & therapeutics, , Volume: 29, Issue:12, 2023
Gut-to-brain spreading of pathology in synucleinopathies: A focus on molecular signalling mediators.Behavioural brain research, , 08-24, Volume: 452, 2023
Alpha-synuclein fibrils amplified from multiple system atrophy and Parkinson's disease patient brain spread after intracerebral injection into mouse brain.Brain pathology (Zurich, Switzerland), , Volume: 33, Issue:5, 2023
Blood-Based α-Synuclein Seeding-A New Era for Identifying Parkinsonian Syndromes.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:8, 2023
A Mouse Model of Multiple System Atrophy: Bench to Bedside.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 20, Issue:1, 2023
α-Synuclein Strains and Their Relevance to Parkinson's Disease, Multiple System Atrophy, and Dementia with Lewy Bodies.International journal of molecular sciences, , Jul-28, Volume: 24, Issue:15, 2023
Comparison of biospecimens for α-synuclein seed amplification assays in Parkinson's disease: A systematic review and network meta-analysis.European journal of neurology, , Volume: 30, Issue:12, 2023
α-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis.Translational neurodegeneration, , 08-25, Volume: 12, Issue:1, 2023
A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibrils in Multiple System Atrophy.Journal of medicinal chemistry, , 09-14, Volume: 66, Issue:17, 2023
Beyond Strains: Molecular Diversity in Alpha-Synuclein at the Center of Disease Heterogeneity.International journal of molecular sciences, , Aug-25, Volume: 24, Issue:17, 2023
Phosphorylated α-synuclein in skin Schwann cells: a new biomarker for multiple system atrophy.Brain : a journal of neurology, , 03-01, Volume: 146, Issue:3, 2023
Host oligodendrogliopathy and α-synuclein strains dictate disease severity in multiple system atrophy.Brain : a journal of neurology, , 01-05, Volume: 146, Issue:1, 2023
The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases.Nature communications, , 10-27, Volume: 14, Issue:1, 2023
PET imaging in animal models of Parkinson's disease.Behavioural brain research, , 02-13, Volume: 438, 2023
[no title available]Biomolecular NMR assignments, , Volume: 17, Issue:2, 2023
Monitoring α-synuclein aggregation.Neurobiology of disease, , Volume: 176, 2023
α-Synuclein emulsifies TDP-43 prion-like domain-RNA liquid droplets to promote heterotypic amyloid fibrils.Communications biology, , Dec-05, Volume: 6, Issue:1, 2023
Somatic SNCA Copy Number Variants in Multiple System Atrophy are Related to Pathology and Inclusions.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:2, 2023
The morphological substrate of memory impairment in multiple system atrophy.Neuropathology and applied neurobiology, , Volume: 49, Issue:1, 2023
Lifelong constipation in Parkinson's disease and other clinically defined alpha-synucleinopathies: A population-based study in Southeast Minnesota.Parkinsonism & related disorders, , Volume: 107, 2023
iPSC-Derived Striatal Medium Spiny Neurons from Patients with Multiple System Atrophy Show Hypoexcitability and Elevated α-Synuclein Release.Cells, , 01-04, Volume: 12, Issue:2, 2023
Multiple system atrophy: at the crossroads of cellular, molecular and genetic mechanisms.Nature reviews. Neuroscience, , Volume: 24, Issue:6, 2023
[Novel Treatment of Multiple System Atrophy in the Era of the New MDS Criteria].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 75, Issue:2, 2023
Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils.Proceedings of the National Academy of Sciences of the United States of America, , 02-14, Volume: 120, Issue:7, 2023
Differential involvement of amyloidogenic evolvability in oligodendropathies; Multiple Sclerosis and Multiple System Atrophy.Prion, , Volume: 17, Issue:1, 2023
α-Synuclein Conformational Strains as Drivers of Phenotypic Heterogeneity in Neurodegenerative Diseases.Journal of molecular biology, , 06-15, Volume: 435, Issue:12, 2023
Oligodendrocytes Prune Axons Containing α-Synuclein Aggregates In Vivo: Lewy Neurites as Precursors of Glial Cytoplasmic Inclusions in Multiple System Atrophy?Biomolecules, , 02-01, Volume: 13, Issue:2, 2023
Differential immunophenotypes of neuronal cytoplasmic inclusions in the dentate gyrus of multiple system atrophy and their association with clinicopathological features.Journal of neuropathology and experimental neurology, , 03-20, Volume: 82, Issue:4, 2023
New SNCA mutation and structures of α-synuclein filaments from juvenile-onset synucleinopathy.Acta neuropathologica, , Volume: 145, Issue:5, 2023
Serotonin in synucleinopathies.Behavioural brain research, , 05-08, Volume: 445, 2023
Role of Oligodendrocyte Lineage Cells in Multiple System Atrophy.Cells, , 02-25, Volume: 12, Issue:5, 2023
α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies.Translational neurodegeneration, , 03-14, Volume: 12, Issue:1, 2023
Could JC virus be involved in the onset of multiple system atrophy? A hypothesis.Parkinsonism & related disorders, , Volume: 109, 2023
Urinary tract infections trigger synucleinopathy via the innate immune response.Acta neuropathologica, , Volume: 145, Issue:5, 2023
⍺-Synuclein Structural Diversity and the Cellular Environment in ⍺-Synuclein Transmission Models and Humans.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 20, Issue:1, 2023
Epsin2, a novel target for multiple system atrophy therapy via α-synuclein/FABP7 propagation.Brain : a journal of neurology, , 08-01, Volume: 146, Issue:8, 2023
Current Progress in the Development of Probes for Targeting α-Synuclein Aggregates.ACS chemical neuroscience, , 03-02, Volume: 13, Issue:5, 2022
Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders.Acta neuropathologica communications, , 11-12, Volume: 10, Issue:1, 2022
Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies.Acta neuropathologica communications, , 06-03, Volume: 10, Issue:1, 2022
In vivo imaging of alpha-synuclein with antibody-based PET.Neuropharmacology, , 05-01, Volume: 208, 2022
Fluid markers of synapse degeneration in synucleinopathies.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 129, Issue:2, 2022
Upregulation of α-synuclein following immune activation: Possible trigger of Parkinson's disease.Neurobiology of disease, , Volume: 166, 2022
High-Contrast Imaging of α-Synuclein Pathologies in Living Patients with Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:10, 2022
In vivo and autopsy validation of alpha-synuclein seeding activity using RT-QuIC assay in the gastrointestinal tract of patients with Parkinson's disease.Parkinsonism & related disorders, , Volume: 103, 2022
Family History for Neurodegeneration in Multiple System Atrophy: Does it Indicate Susceptibility?Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:11, 2022
Alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy.Translational neurodegeneration, , 02-07, Volume: 11, Issue:1, 2022
Multiple system atrophy prions transmit neurological disease to mice expressing wild-type human α-synuclein.Acta neuropathologica, , Volume: 144, Issue:4, 2022
Synucleinopathy in Amyotrophic Lateral Sclerosis: A Potential Avenue for Antisense Therapeutics?International journal of molecular sciences, , Aug-19, Volume: 23, Issue:16, 2022
Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy.Proceedings of the National Academy of Sciences of the United States of America, , 02-08, Volume: 119, Issue:6, 2022
Combined CSF α-SYN RT-QuIC, CSF NFL and midbrain-pons planimetry in degenerative parkinsonisms: From bedside to bench, and back again.Parkinsonism & related disorders, , Volume: 99, 2022
Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:10, 2022
Impaired Sphingolipid Hydrolase Activities in Dementia with Lewy Bodies and Multiple System Atrophy.Molecular neurobiology, , Volume: 59, Issue:4, 2022
Glutathione Depletion and MicroRNA Dysregulation in Multiple System Atrophy: A Review.International journal of molecular sciences, , Dec-01, Volume: 23, Issue:23, 2022
Infectious Agents as Potential Drivers of α-Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:3, 2022
mTOR Inhibition with Sirolimus in Multiple System Atrophy: A Randomized, Double-Blind, Placebo-Controlled Futility Trial and 1-Year Biomarker Longitudinal Analysis.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:4, 2022
Pathological Appearance of a Case of Preclinical Multiple System Atrophy: A Comparison With Advanced Cases.Journal of neuropathology and experimental neurology, , 11-16, Volume: 81, Issue:12, 2022
Aggregated Alpha-Synuclein Inclusions within the Nucleus Predict Impending Neuronal Cell Death in a Mouse Model of Parkinsonism.International journal of molecular sciences, , Dec-04, Volume: 23, Issue:23, 2022
Combining Skin α-Synuclein Real-Time Quaking-Induced Conversion and Circulating Neurofilament Light Chain to Distinguish Multiple System Atrophy and Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:3, 2022
Diagnostic value of α-synuclein seeding amplification assays in α-synucleinopathies: A systematic review and meta-analysis.Parkinsonism & related disorders, , Volume: 104, 2022
Disease-Modifying Therapies for Multiple System Atrophy: Where Are We in 2022?Journal of Parkinson's disease, , Volume: 12, Issue:5, 2022
Unique seeding profiles and prion-like propagation of synucleinopathies are highly dependent on the host in human α-synuclein transgenic mice.Acta neuropathologica, , Volume: 143, Issue:6, 2022
Clinical correlations of cerebrospinal fluid biomarkers including neuron-glia 2 and neurofilament light chain in patients with multiple system atrophy.Parkinsonism & related disorders, , Volume: 102, 2022
Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies.Brain : a journal of neurology, , 04-18, Volume: 145, Issue:2, 2022
Development of an α-synuclein fibril and oligomer specific tracer for diagnosis of Parkinson's disease, dementia with Lewy bodies and multiple system atrophy.Neurochemistry international, , Volume: 161, 2022
Involvement of autophagic protein DEF8 in Lewy bodies.Biochemical and biophysical research communications, , 10-01, Volume: 623, 2022
α-Synuclein Seed Amplification Assays for Diagnosing Synucleinopathies: The Way Forward.Neurology, , 08-02, Volume: 99, Issue:5, 2022
The E46K mutation modulates α-synuclein prion replication in transgenic mice.PLoS pathogens, , Volume: 18, Issue:12, 2022
Long-standing multiple system atrophy-Parkinsonism with limbic and FTLD-type α-synuclein pathology.Neuropathology and applied neurobiology, , Volume: 48, Issue:3, 2022
Pathological substrate of memory impairment in multiple system atrophy.Neuropathology and applied neurobiology, , Volume: 48, Issue:7, 2022
Recent advances in establishing fluid biomarkers for the diagnosis and differentiation of alpha-synucleinopathies - a mini review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 32, Issue:4, 2022
The role of cardiovascular autonomic failure in the differential diagnosis of α-synucleinopathies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 43, Issue:1, 2022
Multiple system atrophy variant with severe hippocampal pathology.Brain pathology (Zurich, Switzerland), , Volume: 32, Issue:1, 2022
α-Synuclein Conformational Plasticity: Physiologic States, Pathologic Strains, and Biotechnological Applications.Biomolecules, , 07-17, Volume: 12, Issue:7, 2022
Multiple system atrophy: α-Synuclein strains at the neuron-oligodendrocyte crossroad.Molecular neurodegeneration, , 11-26, Volume: 17, Issue:1, 2022
The Compound ATH434 Prevents Alpha-Synuclein Toxicity in a Murine Model of Multiple System Atrophy.Journal of Parkinson's disease, , Volume: 12, Issue:1, 2022
Quaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein.Communications biology, , 09-30, Volume: 5, Issue:1, 2022
Neurons with Cat's Eyes: A Synthetic Strain of α-Synuclein Fibrils Seeding Neuronal Intranuclear Inclusions.Biomolecules, , 03-11, Volume: 12, Issue:3, 2022
Parkinson's disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein-induced changes in maturation and immune reactive properties.Proceedings of the National Academy of Sciences of the United States of America, , 03-22, Volume: 119, Issue:12, 2022
Brain injections of glial cytoplasmic inclusions induce a multiple system atrophy-like pathology.Brain : a journal of neurology, , 04-29, Volume: 145, Issue:3, 2022
Diagnostic Value of Salivary Real-Time Quaking-Induced Conversion in Parkinson's Disease and Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:5, 2022
Cardiac Alpha-Synuclein Is Present in Alpha-Synucleinopathies.Journal of Parkinson's disease, , Volume: 12, Issue:4, 2022
Synuclein-One study: skin biopsy detection of phosphorylated α-synuclein for diagnosis of synucleinopathies.Biomarkers in medicine, , Volume: 16, Issue:7, 2022
Pathological Relevance of Post-Translationally Modified Alpha-Synuclein (pSer87, pSer129, nTyr39) in Idiopathic Parkinson's Disease and Multiple System Atrophy.Cells, , 03-06, Volume: 11, Issue:5, 2022
COQ2 and SNCA polymorphisms interact with environmental factors to modulate the risk of multiple system atrophy and subtype disposition.European journal of neurology, , Volume: 29, Issue:10, 2022
Alpha-Synuclein Autoimmune Decline in Prodromal Multiple System Atrophy and Parkinson's Disease.International journal of molecular sciences, , Jun-12, Volume: 23, Issue:12, 2022
Hemoglobin-binding α-synuclein levels in erythrocytes are elevated in patients with multiple system atrophy.Neuroscience letters, , 10-15, Volume: 789, 2022
Alpha-synuclein Immunization Strategies for Synucleinopathies in Clinical Studies: A Biological Perspective.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 19, Issue:5, 2022
Phosphorylation of Tau at Threonine 231 in Patients With Multiple System Atrophy and in a Mouse Model.Journal of neuropathology and experimental neurology, , 10-18, Volume: 81, Issue:11, 2022
Increased unsaturated lipids underlie lipid peroxidation in synucleinopathy brain.Acta neuropathologica communications, , 11-14, Volume: 10, Issue:1, 2022
Phosphorylated α-Synuclein Deposits in Cutaneous Nerves of Early Parkinsonism.Journal of Parkinson's disease, , Volume: 12, Issue:8, 2022
Current experimental disease-modifying therapeutics for multiple system atrophy.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 128, Issue:10, 2021
[Non-motor symptoms of Parkinson's disease from pathophysiology to early diagnosis].La Revue de medecine interne, , Volume: 42, Issue:4, 2021
Systematic Assessment of 10 Biomarker Candidates Focusing on α-Synuclein-Related Disorders.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:12, 2021
Shared Genetics of Multiple System Atrophy and Inflammatory Bowel Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:2, 2021
Viral-based rodent and nonhuman primate models of multiple system atrophy: Fidelity to the human disease.Neurobiology of disease, , Volume: 148, 2021
The Alpha-Synuclein RT-QuIC Products Generated by the Olfactory Mucosa of Patients with Parkinson's Disease and Multiple System Atrophy Induce Inflammatory Responses in SH-SY5Y Cells.Cells, , 12-28, Volume: 11, Issue:1, 2021
Neuropathology of multiple system atrophy: Kurt Jellinger`s legacy.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 128, Issue:10, 2021
MOBP and HIP1 in multiple system atrophy: New α-synuclein partners in glial cytoplasmic inclusions implicated in the disease pathogenesis.Neuropathology and applied neurobiology, , Volume: 47, Issue:5, 2021
Neuropathology and molecular diagnosis of Synucleinopathies.Molecular neurodegeneration, , 12-18, Volume: 16, Issue:1, 2021
Discrimination of MSA-P and MSA-C by RT-QuIC analysis of olfactory mucosa: the first assessment of assay reproducibility between two specialized laboratories.Molecular neurodegeneration, , 12-11, Volume: 16, Issue:1, 2021
Inflammation in Experimental Models of α-Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:1, 2021
RT-QUiC in multiple system atrophy: the biomarker of the future? and other updates on recent autonomic research.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 31, Issue:1, 2021
Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds.Acta neuropathologica communications, , 11-24, Volume: 9, Issue:1, 2021
Seeded assembly in vitro does not replicate the structures of α-synuclein filaments from multiple system atrophy.FEBS open bio, , Volume: 11, Issue:4, 2021
Investigating ELOVL7 coding variants in multiple system atrophy.Neuroscience letters, , 04-01, Volume: 749, 2021
ATH434 Reduces α-Synuclein-Related Neurodegeneration in a Murine Model of Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:11, 2021
Dermal and cardiac autonomic fiber involvement in Parkinson's disease and multiple system atrophy.Neurobiology of disease, , Volume: 153, 2021
Signs of early cellular dysfunction in multiple system atrophy.Neuropathology and applied neurobiology, , Volume: 47, Issue:2, 2021
In Vivo Diagnosis of Synucleinopathies: A Comparative Study of Skin Biopsy and RT-QuIC.Neurology, , 05-18, Volume: 96, Issue:20, 2021
Human alpha-synuclein overexpressing MBP29 mice mimic functional and structural hallmarks of the cerebellar subtype of multiple system atrophy.Acta neuropathologica communications, , 04-14, Volume: 9, Issue:1, 2021
In situ architecture of neuronal α-Synuclein inclusions.Nature communications, , 04-14, Volume: 12, Issue:1, 2021
Role of VAPB and vesicular profiles in α-synuclein aggregates in multiple system atrophy.Brain pathology (Zurich, Switzerland), , Volume: 31, Issue:6, 2021
Phenotypic manifestation of α-synuclein strains derived from Parkinson's disease and multiple system atrophy in human dopaminergic neurons.Nature communications, , 06-21, Volume: 12, Issue:1, 2021
Alpha-Synuclein Oligomers and Neurofilament Light Chain Predict Phenoconversion of Pure Autonomic Failure.Annals of neurology, , Volume: 89, Issue:6, 2021
Structural and Functional Insights into α-Synuclein Fibril Polymorphism.Biomolecules, , 09-28, Volume: 11, Issue:10, 2021
Phytochemicals as Regulators of Genes Involved in Synucleinopathies.Biomolecules, , 04-22, Volume: 11, Issue:5, 2021
Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple system atrophy.Acta neuropathologica communications, , 05-03, Volume: 9, Issue:1, 2021
A historical review of multiple system atrophy with a critical appraisal of cellular and animal models.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 128, Issue:10, 2021
Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential.Acta neuropathologica, , Volume: 142, Issue:1, 2021
α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson's disease from multiple system atrophy.Acta neuropathologica, , Volume: 142, Issue:3, 2021
Is Multiple System Atrophy a Prion-like Disorder?International journal of molecular sciences, , Sep-18, Volume: 22, Issue:18, 2021
Cerebrospinal fluid and plasma distribution of anti-α-synuclein IgMs and IgGs in multiple system atrophy and Parkinson's disease.Parkinsonism & related disorders, , Volume: 87, 2021
Phosphorylated α-synuclein and phosphorylated tau-protein in sural nerves may contribute to differentiate Parkinson's disease from multiple system atrophy and progressive supranuclear paralysis.Neuroscience letters, , 06-21, Volume: 756, 2021
Therapeutic potential of iron modulating drugs in a mouse model of multiple system atrophy.Neurobiology of disease, , Volume: 159, 2021
Diagnostic utility of fluid biomarkers in multiple system atrophy: a systematic review and meta-analysis.Journal of neurology, , Volume: 268, Issue:8, 2021
Electron Microscopic Analysis of α-Synuclein Fibrils.Methods in molecular biology (Clifton, N.J.), , Volume: 2322, 2021
Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies.Acta neuropathologica communications, , 08-28, Volume: 9, Issue:1, 2021
Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo.Nature communications, , 09-10, Volume: 12, Issue:1, 2021
Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy.Journal of cellular and molecular medicine, , Volume: 25, Issue:20, 2021
Somatic mutations in neurodegeneration: An update.Neurobiology of disease, , Volume: 144, 2020
Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy.Cells, , 10-29, Volume: 9, Issue:11, 2020
Multiplicity of α-Synuclein Aggregated Species and Their Possible Roles in Disease.International journal of molecular sciences, , Oct-28, Volume: 21, Issue:21, 2020
Cerebral white matter tau-positive granular glial pathology as a characteristic pathological feature in long survivors of multiple system atrophy.Journal of the neurological sciences, , 09-15, Volume: 416, 2020
Novel antibodies detect additional α-synuclein pathology in synucleinopathies: potential development for immunotherapy.Alzheimer's research & therapy, , 11-30, Volume: 12, Issue:1, 2020
Comparison of 123I-MIBG scintigraphy and phosphorylated α-synuclein skin deposits in synucleinopathies.Parkinsonism & related disorders, , Volume: 81, 2020
Skin Biopsy May Help to Distinguish Multiple System Atrophy-Parkinsonism from Parkinson's Disease With Orthostatic Hypotension.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:9, 2020
Conjugal multiple system atrophy: Be wary of implicating transmissibility.Parkinsonism & related disorders, , Volume: 75, 2020
Alpha-Synuclein Oligomers and Neurofilament Light Chain in Spinal Fluid Differentiate Multiple System Atrophy from Lewy Body Synucleinopathies.Annals of neurology, , Volume: 88, Issue:3, 2020
Conjugal multiple system atrophy: Computing chance or investigating real patients?Parkinsonism & related disorders, , Volume: 75, 2020
Structures of α-synuclein filaments from multiple system atrophy.Nature, , Volume: 585, Issue:7825, 2020
White matter DNA methylation profiling reveals deregulation of HIP1, LMAN2, MOBP, and other loci in multiple system atrophy.Acta neuropathologica, , Volume: 139, Issue:1, 2020
Targeting α-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance.Translational neurodegeneration, , 09-24, Volume: 9, Issue:1, 2020
Reduced oligodendrocyte exosome secretion in multiple system atrophy involves SNARE dysfunction.Brain : a journal of neurology, , 06-01, Volume: 143, Issue:6, 2020
The good and bad of therapeutic strategies that directly target α-synuclein.IUBMB life, , Volume: 72, Issue:4, 2020
FTY720-Mitoxy reduces synucleinopathy and neuroinflammation, restores behavior and mitochondria function, and increases GDNF expression in Multiple System Atrophy mouse models.Experimental neurology, , Volume: 325, 2020
Hippocampal α-synuclein pathology correlates with memory impairment in multiple system atrophy.Brain : a journal of neurology, , 06-01, Volume: 143, Issue:6, 2020
A Phase 1 Randomized Trial of Specific Active α-Synuclein Immunotherapies PD01A and PD03A in Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:11, 2020
The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson's disease, multiple system atrophy and dementia with Lewy bodies.Acta neuropathologica, , Volume: 139, Issue:6, 2020
High-salt diet does not boost neuroinflammation and neurodegeneration in a model of α-synucleinopathy.Journal of neuroinflammation, , Jan-24, Volume: 17, Issue:1, 2020
Conjugal multiple system atrophy: Rethinking numbers of probability.Parkinsonism & related disorders, , Volume: 77, 2020
Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophy.PLoS pathogens, , Volume: 16, Issue:2, 2020
Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy.Nature, , Volume: 578, Issue:7794, 2020
[REM Sleep Behavior Disorder and α-synucleinopathy].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:2, 2020
Lower Vitamin B12 Level at Multiple System Atrophy Diagnosis Is Associated With Shorter Survival.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:8, 2020
Neurodegenerative diseases distinguished through protein-structure analysis.Nature, , Volume: 578, Issue:7794, 2020
Analysis of Protein Conformational Strains-A Key for New Diagnostic Methods of Human Diseases.International journal of molecular sciences, , Apr-17, Volume: 21, Issue:8, 2020
Current Symptomatic and Disease-Modifying Treatments in Multiple System Atrophy.International journal of molecular sciences, , Apr-16, Volume: 21, Issue:8, 2020
Phenotypic Heterogeneity in α-Synucleinopathies: Straining the Difference.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:4, 2020
Nilotinib Fails to Prevent Synucleinopathy and Cell Loss in a Mouse Model of Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:7, 2020
Insights into the pathogenesis of multiple system atrophy: focus on glial cytoplasmic inclusions.Translational neurodegeneration, , Volume: 9, 2020
Synthesis and characterization of high affinity fluorogenic α-synuclein probes.Chemical communications (Cambridge, England), , Mar-24, Volume: 56, Issue:24, 2020
Synuclein in red blood cells: a potential biomarker for multiple system atrophy, and other updates on recent autonomic research.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 30, Issue:2, 2020
Current Management and Emerging Therapies in Multiple System Atrophy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 17, Issue:4, 2020
Disease-Specific Strains of α-Synuclein in Multiple System Atrophy and Parkinson's Disease: But Why?Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:5, 2020
BCAS1-positive immature oligodendrocytes are affected by the α-synuclein-induced pathology of multiple system atrophy.Acta neuropathologica communications, , 07-29, Volume: 8, Issue:1, 2020
Cerebral mitochondrial electron transport chain dysfunction in multiple system atrophy and Parkinson's disease.Scientific reports, , 04-25, Volume: 9, Issue:1, 2019
Moving forward the in vivo diagnosis of the synucleinopathies.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 29, Issue:6, 2019
Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid - method comparison and round robin study.Journal of neurochemistry, , Volume: 149, Issue:1, 2019
"Minimal change" multiple system atrophy with limbic-predominant α-synuclein pathology.Acta neuropathologica, , Volume: 137, Issue:1, 2019
Oligodendroglial α-synucleinopathy-driven neuroinflammation in multiple system atrophy.Brain pathology (Zurich, Switzerland), , Volume: 29, Issue:3, 2019
Alpha-synuclein in erythrocyte membrane of patients with multiple system atrophy: A pilot study.Parkinsonism & related disorders, , Volume: 60, 2019
Cross-examining candidate genes implicated in multiple system atrophy.Acta neuropathologica communications, , 07-24, Volume: 7, Issue:1, 2019
TIGAR inclusion pathology is specific for Lewy body diseases.Brain research, , 03-01, Volume: 1706, 2019
Alpha-synuclein structure and Parkinson's disease - lessons and emerging principles.Molecular neurodegeneration, , 07-22, Volume: 14, Issue:1, 2019
Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines.Acta neuropathologica, , Volume: 137, Issue:3, 2019
The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy.Biochimica et biophysica acta. Molecular basis of disease, , 11-01, Volume: 1865, Issue:11, 2019
Understanding the pathogenesis of multiple system atrophy: state of the art and future perspectives.Acta neuropathologica communications, , 07-12, Volume: 7, Issue:1, 2019
FTY720-Mitoxy reduces toxicity associated with MSA-like α-synuclein and oxidative stress by increasing trophic factor expression and myelin protein in OLN-93 oligodendroglia cell cultures.Neuropharmacology, , 11-01, Volume: 158, 2019
Abnormal α-synuclein deposits in skin nerves: intra- and inter-laboratory reproducibility.European journal of neurology, , Volume: 26, Issue:10, 2019
Multiple system atrophy and myoclonus: A morphologic marker in the spinal cord?Neurology, , 08-13, Volume: 93, Issue:7, 2019
Spinal cord α-synuclein deposition associated with myoclonus in patients with MSA-C.Neurology, , 08-13, Volume: 93, Issue:7, 2019
Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies.JCI insight, , 08-22, Volume: 4, Issue:16, 2019
Binding of α-synuclein oligomers to Cx32 facilitates protein uptake and transfer in neurons and oligodendrocytes.Acta neuropathologica, , Volume: 138, Issue:1, 2019
Shrinkage of the myenteric neurons of the small intestine in patients with multiple system atrophy.Autonomic neuroscience : basic & clinical, , Volume: 221, 2019
Silver staining (Campbell-Switzer) of neuronal α-synuclein assemblies induced by multiple system atrophy and Parkinson's disease brain extracts in transgenic mice.Acta neuropathologica communications, , 09-16, Volume: 7, Issue:1, 2019
Dissecting α-synuclein inclusion pathology diversity in multiple system atrophy: implications for the prion-like transmission hypothesis.Laboratory investigation; a journal of technical methods and pathology, , Volume: 99, Issue:7, 2019
Stabilization of α-synuclein oligomers using formaldehyde.PloS one, , Volume: 14, Issue:10, 2019
Distinct Autoimmune Anti-α-Synuclein Antibody Patterns in Multiple System Atrophy and Parkinson's Disease.Frontiers in immunology, , Volume: 10, 2019
Progressive supranuclear palsy, multiple system atrophy and corticobasal degeneration.Handbook of clinical neurology, , Volume: 165, 2019
Parkinson's disease and multiple system atrophy have distinct α-synuclein seed characteristics.The Journal of biological chemistry, , 01-18, Volume: 294, Issue:3, 2019
Luminescent conjugated oligothiophenes distinguish between α-synuclein assemblies of Parkinson's disease and multiple system atrophy.Acta neuropathologica communications, , 12-03, Volume: 7, Issue:1, 2019
Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts.Nature communications, , 12-04, Volume: 10, Issue:1, 2019
Investigation of somatic CNVs in brains of synucleinopathy cases using targeted SNCA analysis and single cell sequencing.Acta neuropathologica communications, , 12-23, Volume: 7, Issue:1, 2019
Phosphorylated NUB1 distinguishes α-synuclein in Lewy bodies from that in glial cytoplasmic inclusions in multiple system atrophy.Brain pathology (Zurich, Switzerland), , Volume: 29, Issue:6, 2019
Living in Promiscuity: The Multiple Partners of Alpha-Synuclein at the Synapse in Physiology and Pathology.International journal of molecular sciences, , Jan-02, Volume: 20, Issue:1, 2019
Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models.Acta neuropathologica, , Volume: 138, Issue:3, 2019
The heart of PD: Lewy body diseases as neurocardiologic disorders.Brain research, , 01-01, Volume: 1702, 2019
Comparative analyses of the in vivo induction and transmission of α-synuclein pathology in transgenic mice by MSA brain lysate and recombinant α-synuclein fibrils.Acta neuropathologica communications, , 05-20, Volume: 7, Issue:1, 2019
Abundance of Synaptic Vesicle-Related Proteins in Alpha-Synuclein-Containing Protein Inclusions Suggests a Targeted Formation Mechanism.Neurotoxicity research, , Volume: 35, Issue:4, 2019
Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human α-synuclein.Acta neuropathologica communications, , 05-20, Volume: 7, Issue:1, 2019
Coexisting Lewy body disease and clinical parkinsonism in frontotemporal lobar degeneration.Neurology, , 05-21, Volume: 92, Issue:21, 2019
A mouse model of adult-onset multiple system atrophy.Neurobiology of disease, , Volume: 127, 2019
Anle138b modulates α-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:2, 2019
Wide distribution of alpha-synuclein oligomers in multiple system atrophy brain detected by proximity ligation.Acta neuropathologica, , Volume: 137, Issue:3, 2019
When Do α-Synucleinopathies Start? An Epidemiological Timeline: A Review.JAMA neurology, , 04-01, Volume: 75, Issue:4, 2018
Familial Parkinson's point mutation abolishes multiple system atrophy prion replication.Proceedings of the National Academy of Sciences of the United States of America, , 01-09, Volume: 115, Issue:2, 2018
AMBRA1, a novel α-synuclein-binding protein, is implicated in the pathogenesis of multiple system atrophy.Brain pathology (Zurich, Switzerland), , Volume: 28, Issue:1, 2018
Investigating the neuroprotective effect of AAV-mediated β-synuclein overexpression in a transgenic model of synucleinopathy.Scientific reports, , 12-03, Volume: 8, Issue:1, 2018
LRRK2 p.Ile1371Val Mutation in a Case with Neuropathologically Confirmed Multi-System Atrophy.Journal of Parkinson's disease, , Volume: 8, Issue:1, 2018
Converging Patterns of α-Synuclein Pathology in Multiple System Atrophy.Journal of neuropathology and experimental neurology, , 11-01, Volume: 77, Issue:11, 2018
The Relevance of Iron in the Pathogenesis of Multiple System Atrophy: A Viewpoint.Journal of Alzheimer's disease : JAD, , Volume: 61, Issue:4, 2018
α-Synuclein strains in multiple system atrophy: A product of their environment?Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:8, 2018
Skin α-synuclein deposits differ in clinical variants of synucleinopathy: an in vivo study.Scientific reports, , 09-24, Volume: 8, Issue:1, 2018
FKBP12-immunopositive inclusions in patients with α-synucleinopathies.Brain research, , 02-01, Volume: 1680, 2018
Key themes and future prospects in translational multiple system atrophy research.Autonomic neuroscience : basic & clinical, , Volume: 211, 2018
NLRP3 Inflammasome-Related Proteins Are Upregulated in the Putamen of Patients With Multiple System Atrophy.Journal of neuropathology and experimental neurology, , 11-01, Volume: 77, Issue:11, 2018
Recent advances in neuropathology, biomarkers and therapeutic approach of multiple system atrophy.Journal of neurology, neurosurgery, and psychiatry, , Volume: 89, Issue:2, 2018
Lysosomal response in relation to α-synuclein pathology differs between Parkinson's disease and multiple system atrophy.Neurobiology of disease, , Volume: 114, 2018
MSA prions exhibit remarkable stability and resistance to inactivation.Acta neuropathologica, , Volume: 135, Issue:1, 2018
Amyloid-Beta Radiotracer [Contrast media & molecular imaging, , Volume: 2018, 2018
Detecting Alpha Synuclein Seeding Activity in Formaldehyde-Fixed MSA Patient Tissue by PMCA.Molecular neurobiology, , Volume: 55, Issue:11, 2018
TDP-43 pathology in multiple system atrophy: colocalization of TDP-43 and α-synuclein in glial cytoplasmic inclusions.Neuropathology and applied neurobiology, , Volume: 44, Issue:7, 2018
Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods.Acta neuropathologica communications, , 04-18, Volume: 6, Issue:1, 2018
α-Synuclein: Multiple System Atrophy Prions.Cold Spring Harbor perspectives in medicine, , 07-02, Volume: 8, Issue:7, 2018
Epothilone D inhibits microglia-mediated spread of alpha-synuclein aggregates.Molecular and cellular neurosciences, , Volume: 89, 2018
ɑ-Synuclein strains and seeding in Parkinson's disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences.Cell and tissue research, , Volume: 373, Issue:1, 2018
The neuropathology of multiple system atrophy and its therapeutic implications.Autonomic neuroscience : basic & clinical, , Volume: 211, 2018
Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy.Stem cell reports, , 02-13, Volume: 10, Issue:2, 2018
Alpha-synuclein levels in patients with multiple system atrophy: a meta-analysis.The International journal of neuroscience, , Volume: 128, Issue:5, 2018
Limited effects of dysfunctional macroautophagy on the accumulation of extracellularly derived α-synuclein in oligodendroglia: implications for MSA pathogenesis.BMC neuroscience, , 05-21, Volume: 19, Issue:1, 2018
Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated.Brain : a journal of neurology, , 07-01, Volume: 141, Issue:7, 2018
Translational therapies for multiple system atrophy: Bottlenecks and future directions.Autonomic neuroscience : basic & clinical, , Volume: 211, 2018
The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson's disease.Scientific reports, , 11-01, Volume: 8, Issue:1, 2018
Rapid eye movement sleep behavior disorder and the link to alpha-synucleinopathies.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, , Volume: 129, Issue:8, 2018
Present and future of disease-modifying therapies in multiple system atrophy.Autonomic neuroscience : basic & clinical, , Volume: 211, 2018
Somatic copy number gains of α-synuclein (SNCA) in Parkinson's disease and multiple system atrophy brains.Brain : a journal of neurology, , 08-01, Volume: 141, Issue:8, 2018
Progressive striatonigral degeneration in a transgenic mouse model of multiple system atrophy: translational implications for interventional therapies.Acta neuropathologica communications, , 01-03, Volume: 6, Issue:1, 2018
Multiple System Atrophy: An Oligodendroglioneural Synucleinopathy1.Journal of Alzheimer's disease : JAD, , Volume: 62, Issue:3, 2018
Multiple system atrophy and apolipoprotein E.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:4, 2018
Extracellular Interactions of Alpha-Synuclein in Multiple System Atrophy.International journal of molecular sciences, , Dec-19, Volume: 19, Issue:12, 2018
Genetics of Synucleinopathies.Cold Spring Harbor perspectives in medicine, , 06-01, Volume: 8, Issue:6, 2018
Is multiple system atrophy an infectious disease?Annals of neurology, , Volume: 83, Issue:1, 2018
Synucleinopathies: common features and hippocampal manifestations.Cellular and molecular life sciences : CMLS, , Volume: 74, Issue:8, 2017
Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates.Acta neuropathologica communications, , 06-16, Volume: 5, Issue:1, 2017
Profile of cognitive impairment and underlying pathology in multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:3, 2017
Increased aneuploidy is not a universal feature across α-synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:3, 2017
Autoimmune antibody decline in Parkinson's disease and Multiple System Atrophy; a step towards immunotherapeutic strategies.Molecular neurodegeneration, , 06-07, Volume: 12, Issue:1, 2017
Viral-mediated oligodendroglial alpha-synuclein expression models multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:8, 2017
Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid.JAMA neurology, , Feb-01, Volume: 74, Issue:2, 2017
Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy.Acta neuropathologica communications, , 01-05, Volume: 5, Issue:1, 2017
Survival and Causes of Death Among People With Clinically Diagnosed Synucleinopathies With Parkinsonism: A Population-Based Study.JAMA neurology, , 07-01, Volume: 74, Issue:7, 2017
Fluorescence and autoradiographic evaluation of tau PET ligand PBB3 to α-synuclein pathology.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:6, 2017
Perirhinal accumulation of neuronal alpha-synuclein in a multiple system atrophy patient with dementia.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 37, Issue:5, 2017
Potential Modes of Intercellular α-Synuclein Transmission.International journal of molecular sciences, , Feb-22, Volume: 18, Issue:2, 2017
Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy.Molecular neurodegeneration, , 07-04, Volume: 12, Issue:1, 2017
α-synuclein astrogliopathy: A possible specific feature in α-synucleinopathy.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 37, Issue:4, 2017
α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies.Nature medicine, , Feb-07, Volume: 23, Issue:2, 2017
The Synucleinopathies: Twenty Years On.Journal of Parkinson's disease, , Volume: 7, Issue:s1, 2017
Brain monoamine oxidase B and A in human parkinsonian dopamine deficiency disorders.Brain : a journal of neurology, , Sep-01, Volume: 140, Issue:9, 2017
Insulin resistance and exendin-4 treatment for multiple system atrophy.Brain : a journal of neurology, , May-01, Volume: 140, Issue:5, 2017
Progression of alpha-synuclein pathology in multiple system atrophy of the cerebellar type.Neuropathology and applied neurobiology, , Volume: 43, Issue:4, 2017
Therapeutic approaches to target alpha-synuclein pathology.Experimental neurology, , Volume: 298, Issue:Pt B, 2017
Analysis of the prion protein gene in multiple system atrophy.Neurobiology of aging, , Volume: 49, 2017
Animal modeling an oligodendrogliopathy--multiple system atrophy.Acta neuropathologica communications, , Feb-09, Volume: 4, 2016
Preface.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Overlaps between multiple system atrophy and multiple sclerosis: A novel perspective.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:12, 2016
α-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy.Acta neuropathologica, , Volume: 132, Issue:1, 2016
α-Synuclein: Experimental Pathology.Cold Spring Harbor perspectives in medicine, , Sep-01, Volume: 6, Issue:9, 2016
Is Multiple System Atrophy a New Prion Disorder?Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:3, 2016
Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy.Proceedings of the National Academy of Sciences of the United States of America, , 08-23, Volume: 113, Issue:34, 2016
Diagnostic utility of CSF α-synuclein species in Parkinson's disease: protocol for a systematic review and meta-analysis.BMJ open, , 06-13, Volume: 6, Issue:6, 2016
MAPT haplotype diversity in multiple system atrophy.Parkinsonism & related disorders, , Volume: 30, 2016
Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril.Scientific reports, , 08-04, Volume: 6, 2016
Imaging synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:6, 2016
Mesenchymal stem cells enhance α-synuclein clearance via M2 microglia polarization in experimental and human parkinsonian disorder.Acta neuropathologica, , Volume: 132, Issue:5, 2016
Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?Journal of Parkinson's disease, , Volume: 6, Issue:1, 2016
Review: Multiple system atrophy: emerging targets for interventional therapies.Neuropathology and applied neurobiology, , Volume: 42, Issue:1, 2016
Neuroprotection by Epigenetic Modulation in a Transgenic Model of Multiple System Atrophy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 13, Issue:4, 2016
'Under pressure': is there a link between orthostatic hypotension and cognitive impairment in α-synucleinopathies?Journal of neurology, neurosurgery, and psychiatry, , Volume: 87, Issue:12, 2016
Altered α-synuclein, parkin, and synphilin isoform levels in multiple system atrophy brains.Journal of neurochemistry, , Volume: 136, Issue:1, 2016
A genome-wide association study in multiple system atrophy.Neurology, , Oct-11, Volume: 87, Issue:15, 2016
Review: The spectrum of clinical features seen with alpha synuclein pathology.Neuropathology and applied neurobiology, , Volume: 42, Issue:1, 2016
Therapeutic approaches in Parkinson's disease and related disorders.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Medullary neuronal loss is not associated with α-synuclein burden in multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:12, 2016
Changes in the miRNA-mRNA Regulatory Network Precede Motor Symptoms in a Mouse Model of Multiple System Atrophy: Clinical Implications.PloS one, , Volume: 11, Issue:3, 2016
Up-regulation of SNCA gene expression: implications to synucleinopathies.Neurogenetics, , Volume: 17, Issue:3, 2016
Development of Passive Immunotherapies for Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Combination therapies: The next logical Step for the treatment of synucleinopathies?Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Review: Novel treatment strategies targeting alpha-synuclein in multiple system atrophy as a model of synucleinopathy.Neuropathology and applied neurobiology, , Volume: 42, Issue:1, 2016
ɑ-Synuclein strains and the variable pathologies of synucleinopathies.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Alpha-synuclein in gastric and colonic mucosa in Parkinson's disease: Limited role as a biomarker.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Strand-specific RNA-sequencing analysis of multiple system atrophy brain transcriptome.Neuroscience, , May-13, Volume: 322, 2016
Active immunization therapies for Parkinson's disease and multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Review: Spreading the word: precise animal models and validated methods are vital when evaluating prion-like behaviour of alpha-synuclein.Neuropathology and applied neurobiology, , Volume: 42, Issue:1, 2016
Reply: Skin biopsies in the differential diagnosis of parkinsonism: are we ready for simplified protocols?Brain : a journal of neurology, , Volume: 139, Issue:Pt 1, 2016
Skin biopsies in the differential diagnosis of parkinsonism: are we ready for simplified protocols?Brain : a journal of neurology, , Volume: 139, Issue:Pt 1, 2016
FBXO7 mutations in Parkinson's disease and multiple system atrophy.Neurobiology of aging, , Volume: 40, 2016
Accumulation of phosphorylated α-synuclein in subpial and periventricular astrocytes in multiple system atrophy of long duration.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 36, Issue:2, 2016
Transcriptome analysis of grey and white matter cortical tissue in multiple system atrophy.Neurogenetics, , Volume: 16, Issue:2, 2015
Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein.Acta neuropathologica communications, , Nov-26, Volume: 3, 2015
SNP rs11931074 of the SNCA gene may not be associated with multiple system atrophy in Chinese population.The International journal of neuroscience, , Volume: 125, Issue:8, 2015
Novel therapeutic approaches in multiple system atrophy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 25, Issue:1, 2015
Animal models of multiple system atrophy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 25, Issue:1, 2015
Models of multiple system atrophy.Current topics in behavioral neurosciences, , Volume: 22, 2015
Multiple system atrophy: the application of genetics in understanding etiology.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 25, Issue:1, 2015
The degree of astrocyte activation in multiple system atrophy is inversely proportional to the distance to α-synuclein inclusions.Molecular and cellular neurosciences, , Volume: 65, 2015
Putative neuropathological interactions in MSA: focus in the rostral ventrolateral medulla.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 25, Issue:1, 2015
Use of CSF α-synuclein in the differential diagnosis between Alzheimer's disease and other neurodegenerative disorders.International psychogeriatrics, , Volume: 27, Issue:9, 2015
Involvement of Peripheral Nerves in the Transgenic PLP-α-Syn Model of Multiple System Atrophy: Extending the Phenotype.PloS one, , Volume: 10, Issue:10, 2015
Minimal change multiple system atrophy: an aggressive variant?Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:7, 2015
Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy.Molecular neurodegeneration, , Mar-19, Volume: 10, 2015
α-Synuclein pathology accumulates in sacral spinal visceral sensory pathways.Annals of neurology, , Volume: 78, Issue:1, 2015
Parkinson's disease and prion disease: Straining the comparison.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:13, 2015
Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.Proceedings of the National Academy of Sciences of the United States of America, , Sep-22, Volume: 112, Issue:38, 2015
Atypical multiple system atrophy is a new subtype of frontotemporal lobar degeneration: frontotemporal lobar degeneration associated with α-synuclein.Acta neuropathologica, , Volume: 130, Issue:1, 2015
Expanding the spectrum of neuronal pathology in multiple system atrophy.Brain : a journal of neurology, , Volume: 138, Issue:Pt 8, 2015
Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative.Neurobiology of disease, , Volume: 80, 2015
Filamentous aggregations of phosphorylated α-synuclein in Schwann cells (Schwann cell cytoplasmic inclusions) in multiple system atrophy.Acta neuropathologica communications, , May-21, Volume: 3, 2015
Phosphorylated α-synuclein in skin nerve fibres differentiates Parkinson's disease from multiple system atrophy.Brain : a journal of neurology, , Volume: 138, Issue:Pt 8, 2015
Neurodegeneration: Aggregates feel the strain.Nature, , Jun-18, Volume: 522, Issue:7556, 2015
α-Synuclein strains cause distinct synucleinopathies after local and systemic administration.Nature, , Jun-18, Volume: 522, Issue:7556, 2015
Screening for α-synuclein immunoreactive neuronal inclusions in the hippocampus allows identification of atypical MSA (FTLD-synuclein).Acta neuropathologica, , Volume: 130, Issue:2, 2015
Survival in synucleinopathies: A prospective cohort study.Neurology, , Nov-03, Volume: 85, Issue:18, 2015
Parkinson disease: Disease-linked morphometric variants of α-synuclein.Nature reviews. Neurology, , Volume: 11, Issue:8, 2015
Distinctive distribution of phospho-alpha-synuclein in dermal nerves in multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:12, 2015
A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy.Molecular neurodegeneration, , Sep-23, Volume: 10, 2015
Failure of Neuroprotection Despite Microglial Suppression by Delayed-Start Myeloperoxidase Inhibition in a Model of Advanced Multiple System Atrophy: Clinical Implications.Neurotoxicity research, , Volume: 28, Issue:3, 2015
Peripheral synuclein tissue markers: a step closer to Parkinson's disease diagnosis.Brain : a journal of neurology, , Volume: 138, Issue:Pt 8, 2015
Genetic Variants of SNCA Are Associated with Susceptibility to Parkinson's Disease but Not Amyotrophic Lateral Sclerosis or Multiple System Atrophy in a Chinese Population.PloS one, , Volume: 10, Issue:7, 2015
Mitochondrial impairment and oxidative stress compromise autophagosomal degradation of α-synuclein in oligodendroglial cells.Journal of neurochemistry, , Volume: 135, Issue:1, 2015
Region-Specific Alterations of Matrix Metalloproteinase Activity in Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:13, 2015
Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation.Molecular neurodegeneration, , Aug-27, Volume: 10, 2015
Role of transcriptional control in multiple system atrophy.Neurobiology of aging, , Volume: 36, Issue:1, 2015
Role for the microtubule-associated protein tau variant p.A152T in risk of α-synucleinopathies.Neurology, , Nov-10, Volume: 85, Issue:19, 2015
Overexpression of α-synuclein in oligodendrocytes does not increase susceptibility to focal striatal excitotoxicity.BMC neuroscience, , Dec-02, Volume: 16, 2015
Expanding the prion disease repertoire.Proceedings of the National Academy of Sciences of the United States of America, , Sep-22, Volume: 112, Issue:38, 2015
Multiple system atrophy: a prototypical synucleinopathy for disease-modifying therapeutic strategies.Neurobiology of disease, , Volume: 67, 2014
Multiple system atrophy as emerging template for accelerated drug discovery in α-synucleinopathies.Parkinsonism & related disorders, , Volume: 20, Issue:8, 2014
Altered lipid levels provide evidence for myelin dysfunction in multiple system atrophy.Acta neuropathologica communications, , Oct-29, Volume: 2, 2014
Evidence piles Up for prion-like propagation mechanisms in synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:2, 2014
α-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy.Neurobiology of aging, , Volume: 35, Issue:10, 2014
Cystatin C triggers neuronal degeneration in a model of multiple system atrophy.The American journal of pathology, , Volume: 184, Issue:3, 2014
Prodegenerative IκBα expression in oligodendroglial α-synuclein models of multiple system atrophy.Neurobiology of disease, , Volume: 63, 2014
[Clinical picture and diagnostic criteria of multiple system atrophy].Rinsho shinkeigaku = Clinical neurology, , Volume: 54, Issue:12, 2014
Antidepressants reduce neuroinflammatory responses and astroglial alpha-synuclein accumulation in a transgenic mouse model of multiple system atrophy.Glia, , Volume: 62, Issue:2, 2014
Multiple system atrophy of the cerebellar type: clinical state of the art.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:3, 2014
β-III Tubulin fragments inhibit α-synuclein accumulation in models of multiple system atrophy.The Journal of biological chemistry, , Aug-29, Volume: 289, Issue:35, 2014
Towards translational therapies for multiple system atrophy.Progress in neurobiology, , Volume: 118, 2014
Alpha-synuclein mRNA expression in oligodendrocytes in MSA.Glia, , Volume: 62, Issue:6, 2014
α-Synucleinopathy phenotypes.Parkinsonism & related disorders, , Volume: 20 Suppl 1, 2014
Update on novel familial forms of Parkinson's disease and multiple system atrophy.Parkinsonism & related disorders, , Volume: 20 Suppl 1, 2014
SNCA variants rs2736990 and rs356220 as risk factors for Parkinson's disease but not for amyotrophic lateral sclerosis and multiple system atrophy in a Chinese population.Neurobiology of aging, , Volume: 35, Issue:12, 2014
Age-related motor dysfunction and neuropathology in a transgenic mouse model of multiple system atrophy.Synapse (New York, N.Y.), , Volume: 68, Issue:3, 2014
CSF α-synuclein and UCH-L1 levels in Parkinson's disease and atypical parkinsonian disorders.Parkinsonism & related disorders, , Volume: 20, Issue:4, 2014
Novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology.Neurobiology of aging, , Volume: 35, Issue:9, 2014
Degeneration of brainstem respiratory neurons in dementia with Lewy bodies.Sleep, , Feb-01, Volume: 37, Issue:2, 2014
Reduced alpha-synuclein in cerebrospinal fluid in synucleinopathies: evidence from a meta-analysis.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:13, 2014
Increase of the plasma α-synuclein levels in patients with multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:3, 2014
Immunohistochemical localization of spatacsin in α-synucleinopathies.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 34, Issue:2, 2014
Neuropathology of multiple system atrophy: new thoughts about pathogenesis.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:14, 2014
Bladder dysfunction in a transgenic mouse model of multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:3, 2013
Differentiation of progressive supranuclear palsy: clinical, imaging and laboratory tools.Acta neurologica Scandinavica, , Volume: 127, Issue:5, 2013
α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?Acta neuropathologica, , Volume: 125, Issue:5, 2013
Increased expression of ABCA8 in multiple system atrophy brain is associated with changes in pathogenic proteins.Journal of Parkinson's disease, , Jan-01, Volume: 3, Issue:3, 2013
The glial marker YKL-40 is decreased in synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:13, 2013
The potential prognostic role of cardiovascular autonomic failure in α-synucleinopathies.European journal of neurology, , Volume: 20, Issue:2, 2013
FBXO7 immunoreactivity in α-synuclein-containing inclusions in Parkinson disease and multiple system atrophy.Journal of neuropathology and experimental neurology, , Volume: 72, Issue:6, 2013
Identification and quantification of oligodendrocyte precursor cells in multiple system atrophy, progressive supranuclear palsy and Parkinson's disease.Brain pathology (Zurich, Switzerland), , Volume: 23, Issue:3, 2013
Intact olfaction in a mouse model of multiple system atrophy.PloS one, , Volume: 8, Issue:5, 2013
Limelight on alpha-synuclein: pathological and mechanistic implications in neurodegeneration.Journal of Parkinson's disease, , Volume: 3, Issue:4, 2013
Loss of DARPP-32 and calbindin in multiple system atrophy.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 120, Issue:12, 2013
100 years of Lewy pathology.Nature reviews. Neurology, , Volume: 9, Issue:1, 2013
Incidence and prevalence of multiple system atrophy: a nationwide study in Iceland.Journal of neurology, neurosurgery, and psychiatry, , Volume: 84, Issue:2, 2013
Transmission of multiple system atrophy prions to transgenic mice.Proceedings of the National Academy of Sciences of the United States of America, , Nov-26, Volume: 110, Issue:48, 2013
Submandibular gland biopsy for the diagnosis of Parkinson disease.Journal of neuropathology and experimental neurology, , Volume: 72, Issue:2, 2013
FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy.PloS one, , Volume: 8, Issue:1, 2013
Oligodendroglial alpha-synucleinopathy and MSA-like cardiovascular autonomic failure: experimental evidence.Experimental neurology, , Volume: 247, 2013
Post mortem cerebrospinal fluid α-synuclein levels are raised in multiple system atrophy and distinguish this from the other α-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies.Neurobiology of disease, , Volume: 45, Issue:1, 2012
Cerebellar-type multiple system atrophy presenting with leucoencephalopathy.Journal of neurology, neurosurgery, and psychiatry, , Volume: 83, Issue:2, 2012
Animal models of multiple system atrophy.Neuroscience, , Jun-01, Volume: 211, 2012
The neuropathology, pathophysiology and genetics of multiple system atrophy.Neuropathology and applied neurobiology, , Volume: 38, Issue:1, 2012
Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders.Archives of neurology, , Volume: 69, Issue:11, 2012
Myeloperoxidase inhibition ameliorates multiple system atrophy-like degeneration in a transgenic mouse model.Neurotoxicity research, , Volume: 21, Issue:4, 2012
Extensive distribution of glial cytoplasmic inclusions in an autopsied case of multiple system atrophy with a prolonged 18-year clinical course.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 32, Issue:1, 2012
Increased neuronal α-synuclein pathology associates with its accumulation in oligodendrocytes in mice modeling α-synucleinopathies.PloS one, , Volume: 7, Issue:10, 2012
α-Synuclein accumulation reduces GABAergic inhibitory transmission in a model of multiple system atrophy.Biochemical and biophysical research communications, , Nov-23, Volume: 428, Issue:3, 2012
Binding of neuronal α-synuclein to β-III tubulin and accumulation in a model of multiple system atrophy.Biochemical and biophysical research communications, , Jan-27, Volume: 417, Issue:4, 2012
Neuronal to oligodendroglial α-synuclein redistribution in a double transgenic model of multiple system atrophy.Neuroreport, , Mar-07, Volume: 23, Issue:4, 2012
An antibody with high reactivity for disease-associated α-synuclein reveals extensive brain pathology.Acta neuropathologica, , Volume: 124, Issue:1, 2012
Involvement of macroautophagy in multiple system atrophy and protein aggregate formation in oligodendrocytes.Journal of molecular neuroscience : MN, , Volume: 47, Issue:2, 2012
Analysis of colonic alpha-synuclein pathology in multiple system atrophy.Parkinsonism & related disorders, , Volume: 18, Issue:7, 2012
Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease.BMC neuroscience, , Aug-03, Volume: 12, 2011
Cerebrospinal fluid from patients with multiple system atrophy promotes in vitro α-synuclein fibril formation.Neuroscience letters, , Mar-10, Volume: 491, Issue:1, 2011
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein.The Journal of biological chemistry, , Sep-30, Volume: 286, Issue:39, 2011
Multiple system atrophy: a clinical and neuropathological perspective.Trends in neurosciences, , Volume: 34, Issue:11, 2011
New insights into atypical parkinsonism.Current opinion in neurology, , Volume: 24, Issue:4, 2011
Tau-positive glial cytoplasmic granules in multiple system atrophy.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 31, Issue:3, 2011
Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression.Annals of neurology, , Volume: 69, Issue:3, 2011
Mesenchymal stem cells in a transgenic mouse model of multiple system atrophy: immunomodulation and neuroprotection.PloS one, , Volume: 6, Issue:5, 2011
[Multiple system atrophy - synuclein and neuronal degeneration].Rinsho shinkeigaku = Clinical neurology, , Volume: 51, Issue:11, 2011
Protein disulfide isomerase immunopositive glial cytoplasmic inclusions in patients with multiple system atrophy.The International journal of neuroscience, , Volume: 121, Issue:10, 2011
Neuropathology underlying clinical variability in patients with synucleinopathies.Acta neuropathologica, , Volume: 122, Issue:2, 2011
α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study.The Lancet. Neurology, , Volume: 10, Issue:3, 2011
Erythropoietin is neuroprotective in a transgenic mouse model of multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Feb-15, Volume: 26, Issue:3, 2011
Role of TPPP/p25 on α-synuclein-mediated oligodendroglial degeneration and the protective effect of SIRT2 inhibition in a cellular model of multiple system atrophy.Neurochemistry international, , Volume: 57, Issue:8, 2010
REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century.Neurology, , Aug-10, Volume: 75, Issue:6, 2010
Involvement of endoplasmic reticulum stress defined by activated unfolded protein response in multiple system atrophy.Journal of the neurological sciences, , Oct-15, Volume: 297, Issue:1-2, 2010
Targeted overexpression of human alpha-synuclein in oligodendroglia induces lesions linked to MSA-like progressive autonomic failure.Experimental neurology, , Volume: 224, Issue:2, 2010
Neurodegeneration in a transgenic mouse model of multiple system atrophy is associated with altered expression of oligodendroglial-derived neurotrophic factors.The Journal of neuroscience : the official journal of the Society for Neuroscience, , May-05, Volume: 30, Issue:18, 2010
SNCA variants and multiple system atrophy.Annals of neurology, , Volume: 67, Issue:4, 2010
In vivo visualization of alpha-synuclein deposition by carbon-11-labelled 2-[2-(2-dimethylaminothiazol-5-yl)ethenyl]-6-[2-(fluoro)ethoxy]benzoxazole positron emission tomography in multiple system atrophy.Brain : a journal of neurology, , Volume: 133, Issue:Pt 6, 2010
Reply to: SNCA variants are associated with increased risk of multiple system atrophy.Annals of neurology, , Volume: 67, Issue:3, 2010
Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease.Acta neuropathologica, , Volume: 119, Issue:6, 2010
Alpha-synuclein deficient mice are resistant to toxin-induced multiple system atrophy.Neuroreport, , Apr-21, Volume: 21, Issue:6, 2010
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-03, Volume: 30, Issue:9, 2010
Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation.Brain : a journal of neurology, , Volume: 133, Issue:Pt 1, 2010
Dopamine cell loss in the periaqueductal gray in multiple system atrophy and Lewy body dementia.Neurology, , Jul-14, Volume: 73, Issue:2, 2009
Leucine-rich repeat kinase 2 expression leads to aggresome formation that is not associated with alpha-synuclein inclusions.Journal of neuropathology and experimental neurology, , Volume: 68, Issue:7, 2009
SNCA variants are associated with increased risk for multiple system atrophy.Annals of neurology, , Volume: 65, Issue:5, 2009
Recent developments in multiple system atrophy.Journal of neurology, , Volume: 256, Issue:11, 2009
Striatal transplantation for multiple system atrophy--are grafts affected by alpha-synucleinopathy?Experimental neurology, , Volume: 219, Issue:1, 2009
Mitochondrial inhibitor 3-nitroproprionic acid enhances oxidative modification of alpha-synuclein in a transgenic mouse model of multiple system atrophy.Journal of neuroscience research, , Volume: 87, Issue:12, 2009
Glucocerebrosidase mutations in 108 neuropathologically confirmed cases of multiple system atrophy.Neurology, , Mar-31, Volume: 72, Issue:13, 2009
Definite multiple system atrophy in a German family.Journal of neurology, neurosurgery, and psychiatry, , Volume: 80, Issue:4, 2009
Microtubule depolymerization suppresses alpha-synuclein accumulation in a mouse model of multiple system atrophy.The American journal of pathology, , Volume: 174, Issue:4, 2009
Degeneration in different parkinsonian syndromes relates to astrocyte type and astrocyte protein expression.Journal of neuropathology and experimental neurology, , Volume: 68, Issue:10, 2009
Multiple system atrophy: an update.The Lancet. Neurology, , Volume: 8, Issue:12, 2009
Concomitant progressive supranuclear palsy and multiple system atrophy: more than a simple twist of fate?Neuroscience letters, , Dec-31, Volume: 467, Issue:3, 2009
[Mechanism of neuronal degeneration of multiple system atrophy].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 61, Issue:9, 2009
Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy.PloS one, , Sep-22, Volume: 4, Issue:9, 2009
LRRK2 and parkin immunoreactivity in multiple system atrophy inclusions.Acta neuropathologica, , Volume: 116, Issue:6, 2008
Multiple system atrophy: a primary oligodendrogliopathy.Annals of neurology, , Volume: 64, Issue:3, 2008
Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:10, 2008
Second consensus statement on the diagnosis of multiple system atrophy.Neurology, , Aug-26, Volume: 71, Issue:9, 2008
Rifampicin reduces alpha-synuclein in a transgenic mouse model of multiple system atrophy.Neuroreport, , Aug-27, Volume: 19, Issue:13, 2008
The somatosensory cortex in multiple system atrophy.Journal of the neurological sciences, , Aug-15, Volume: 271, Issue:1-2, 2008
Differential expression of alpha-synuclein, parkin, and synphilin-1 isoforms in Lewy body disease.Neurogenetics, , Volume: 9, Issue:3, 2008
Loss of A5 noradrenergic neurons in multiple system atrophy.Acta neuropathologica, , Volume: 115, Issue:6, 2008
Rasagiline is neuroprotective in a transgenic model of multiple system atrophy.Experimental neurology, , Volume: 210, Issue:2, 2008
Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease.Brain : a journal of neurology, , Volume: 131, Issue:Pt 3, 2008
Parkinson's disease with Onuf's nucleus involvement mimicking multiple system atrophy.Journal of neurology, neurosurgery, and psychiatry, , Volume: 79, Issue:2, 2008
alpha-Synuclein gene duplication is present in sporadic Parkinson disease.Neurology, , Jan-01, Volume: 70, Issue:1, 2008
Glial cytoplasmic inclusions in neurologically normal elderly: prodromal multiple system atrophy?Acta neuropathologica, , Volume: 116, Issue:3, 2008
Analyses of copy number and mRNA expression level of the alpha-synuclein gene in multiple system atrophy.Journal of medical and dental sciences, , Volume: 55, Issue:1, 2008
Multiple system atrophy: alpha-synuclein and neuronal degeneration.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 27, Issue:5, 2007
Phosphorylated Smad 2/3 colocalizes with phospho-tau inclusions in Pick disease, progressive supranuclear palsy, and corticobasal degeneration but not with alpha-synuclein inclusions in multiple system atrophy or dementia with Lewy bodies.Journal of neuropathology and experimental neurology, , Volume: 66, Issue:11, 2007
Transgenic animal models of neurodegenerative diseases and their application to treatment development.Advanced drug delivery reviews, , Sep-30, Volume: 59, Issue:11, 2007
Microglial activation mediates neurodegeneration related to oligodendroglial alpha-synucleinopathy: implications for multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Nov-15, Volume: 22, Issue:15, 2007
p25alpha relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy.The American journal of pathology, , Volume: 171, Issue:4, 2007
Rostral raphe involvement in Lewy body dementia and multiple system atrophy.Acta neuropathologica, , Volume: 114, Issue:3, 2007
High dose levodopa therapy is not toxic in multiple system atrophy: experimental evidence.Movement disorders : official journal of the Movement Disorder Society, , May-15, Volume: 22, Issue:7, 2007
Multiplex families with multiple system atrophy.Archives of neurology, , Volume: 64, Issue:4, 2007
Tauopathies and synucleinopathies: do cerebrospinal fluid beta-amyloid peptides reflect disease-specific pathogenesis?Journal of neural transmission (Vienna, Austria : 1996), , Volume: 114, Issue:7, 2007
Quantitative PCR-based screening of alpha-synuclein multiplication in multiple system atrophy.Parkinsonism & related disorders, , Volume: 13, Issue:6, 2007
Gene expression changes in postmortem tissue from the rostral pons of multiple system atrophy patients.Movement disorders : official journal of the Movement Disorder Society, , Apr-30, Volume: 22, Issue:6, 2007
Accumulation of Hsc70 and Hsp70 in glial cytoplasmic inclusions in patients with multiple system atrophy.Brain research, , Mar-09, Volume: 1136, Issue:1, 2007
Synucleinopathy with features of both multiple system atrophy and dementia with Lewy bodies.Neuropathology and applied neurobiology, , Volume: 33, Issue:1, 2007
Mutant ubiquitin and p62 immunoreactivity in cases of combined multiple system atrophy and Alzheimer's disease.Acta neuropathologica, , Volume: 113, Issue:4, 2007
Depletion of putative chemosensitive respiratory neurons in the ventral medullary surface in multiple system atrophy.Brain : a journal of neurology, , Volume: 130, Issue:Pt 2, 2007
PINK1, a gene product of PARK6, accumulates in alpha-synucleinopathy brains.Journal of neurology, neurosurgery, and psychiatry, , Volume: 78, Issue:6, 2007
Multiple system atrophy in a patient with the spinocerebellar ataxia 3 gene mutation.Movement disorders : official journal of the Movement Disorder Society, , Jan-15, Volume: 22, Issue:2, 2007
P25alpha immunoreactive but alpha-synuclein immunonegative neuronal inclusions in multiple system atrophy.Acta neuropathologica, , Volume: 111, Issue:2, 2006
Coexistence of PSP and MSA: a case report and review of the literature.Acta neuropathologica, , Volume: 111, Issue:2, 2006
The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 113, Issue:10, 2006
The alpha-synuclein gene in multiple system atrophy.Journal of neurology, neurosurgery, and psychiatry, , Volume: 77, Issue:4, 2006
REM sleep behavior disorder: a possible early marker for synucleinopathies.Neurology, , Mar-28, Volume: 66, Issue:6, 2006
[Subthalamic stimulation in a patient with multiple system atrophy: a clinicopathological report].Revue neurologique, , Volume: 162, Issue:3, 2006
P25alpha immunoreactivity in multiple system atrophy and Parkinson disease.Acta neuropathologica, , Volume: 112, Issue:1, 2006
Multiple system atrophy (MSA): topographic distribution of the alpha-synuclein-associated pathological changes.Parkinsonism & related disorders, , Volume: 12, Issue:6, 2006
Pontine calcification in a case with cerebellar type of multiple system atrophy: incidental or related to synucleinopathy.Internal medicine (Tokyo, Japan), , Volume: 45, Issue:9, 2006
alpha-synuclein from platelets is not phosphorylated at serine 129 in Parkinson's disease and multiple system atrophy.Neuroscience letters, , Sep-25, Volume: 405, Issue:3, 2006
Cellular pathology in multiple system atrophy.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 26, Issue:4, 2006
The role of alpha-synuclein in the pathogenesis of multiple system atrophy.Acta neuropathologica, , Volume: 109, Issue:2, 2005
Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy.The American journal of pathology, , Volume: 166, Issue:3, 2005
Atypical parkinsonism combining alpha-synuclein inclusions and polyglucosan body disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20, Issue:2, 2005
Mouse model of multiple system atrophy alpha-synuclein expression in oligodendrocytes causes glial and neuronal degeneration.Neuron, , Mar-24, Volume: 45, Issue:6, 2005
Glial cell cytoplasmic inclusions in SCA2 do not express alpha-synuclein.Journal of neurology, , Volume: 252, Issue:6, 2005
alpha-Synuclein-immunoreactive structure formation is enhanced in sympathetic ganglia of patients with multiple system atrophy.Acta neuropathologica, , Volume: 110, Issue:1, 2005
Alpha-synuclein overexpression in oligodendrocytic cells results in impaired adhesion to fibronectin and cell death.Molecular and cellular neurosciences, , Volume: 29, Issue:2, 2005
Silver stainings distinguish Lewy bodies and glial cytoplasmic inclusions: comparison between Gallyas-Braak and Campbell-Switzer methods.Acta neuropathologica, , Volume: 110, Issue:3, 2005
Grading of neuropathology in multiple system atrophy: proposal for a novel scale.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
In vitro models of multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
In vivo models of multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
Alpha-synuclein transgenic mice: relevance to multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
Progressive accumulation of ubiquitin and disappearance of alpha-synuclein epitope in multiple system atrophy-associated glial cytoplasmic inclusions: triple fluorescence study combined with Gallyas-Braak method.Acta neuropathologica, , Volume: 110, Issue:4, 2005
Absence of alpha-synuclein mRNA expression in normal and multiple system atrophy oligodendroglia.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 112, Issue:12, 2005
Neurological and neurodegenerative alterations in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-16, Volume: 25, Issue:46, 2005
A quantitative investigation of neuronal cytoplasmic and intranuclear inclusions in the pontine and inferior olivary nuclei in multiple system atrophy.Neuropathology and applied neurobiology, , Volume: 30, Issue:5, 2004
Alpha-synuclein immunoreactivity in neuronal nuclear inclusions and neurites in multiple system atrophy.Neuroscience letters, , Jan-09, Volume: 354, Issue:2, 2004
Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy.Acta neuropathologica, , Volume: 107, Issue:4, 2004
Spatial patterns of alpha-synuclein positive glial cytoplasmic inclusions in multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 19, Issue:1, 2004
Microglial activation parallels system degeneration in multiple system atrophy.Journal of neuropathology and experimental neurology, , Volume: 63, Issue:1, 2004
Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease.Acta neuropathologica, , Volume: 107, Issue:6, 2004
Pael-R is accumulated in Lewy bodies of Parkinson's disease.Annals of neurology, , Volume: 55, Issue:3, 2004
Alpha-synuclein: normal function and role in neurodegenerative diseases.Current topics in developmental biology, , Volume: 60, 2004
Annular alpha-synuclein species from purified multiple system atrophy inclusions.Journal of neurochemistry, , Volume: 90, Issue:2, 2004
Nucleus-specific alteration of raphe neurons in human neurodegenerative disorders.Neuroreport, , Jan-20, Volume: 14, Issue:1, 2003
Alpha-synuclein pathology affecting Bergmann glia of the cerebellum in patients with alpha-synucleinopathies.Acta neuropathologica, , Volume: 105, Issue:4, 2003
Immunoexpression of 14-3-3 proteins in glial cytoplasmic inclusions of multiple system atrophy.Acta neuropathologica, , Volume: 106, Issue:1, 2003
alpha-Synuclein fibrils constitute the central core of oligodendroglial inclusion filaments in multiple system atrophy.Experimental neurology, , Volume: 181, Issue:1, 2003
[Recent neuropathology of parkinsonian syndromes].Revue neurologique, , Volume: 159, Issue:5 Pt 2, 2003
Tau and 14-3-3 in glial cytoplasmic inclusions of multiple system atrophy.Acta neuropathologica, , Volume: 106, Issue:3, 2003
Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies.The American journal of pathology, , Volume: 163, Issue:1, 2003
Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis.The American journal of pathology, , Volume: 163, Issue:2, 2003
Multiple system atrophy: an update.Movement disorders : official journal of the Movement Disorder Society, , Volume: 18 Suppl 6, 2003
Alpha-synuclein accumulates in Purkinje cells in Lewy body disease but not in multiple system atrophy.Journal of neuropathology and experimental neurology, , Volume: 62, Issue:8, 2003
Reciprocal accumulation of beta-synuclein in alpha-synuclein lesions in multiple system atrophy.Neuroreport, , Oct-06, Volume: 14, Issue:14, 2003
Mice expressing the alpha(1B)-adrenergic receptor induces a synucleinopathy with excessive tyrosine nitration but decreased phosphorylation.Journal of neurochemistry, , Volume: 83, Issue:3, 2002
Association of Lewy bodies and glial cytoplasmic inclusions in the brain of Parkinson's disease.Acta neuropathologica, , Volume: 104, Issue:5, 2002
Alpha-synuclein immunoreactivity and ultrastructural study of glial cytoplasmic inclusions in multiple system atrophy.Chinese medical journal, , Volume: 115, Issue:10, 2002
Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes.EMBO reports, , Volume: 3, Issue:6, 2002
Pathology of the inferior olivary nucleus in patients with multiple system atrophy.Acta neuropathologica, , Volume: 103, Issue:6, 2002
[Recent progress in the research of multiple system atrophy with special references to alpha-synuclein and suprachiasmatic nucleus].No to shinkei = Brain and nerve, , Volume: 54, Issue:2, 2002
Mixed multiple system atrophy and progressive supranuclear palsy: a clinical and pathological report of one case.Acta neuropathologica, , Volume: 103, Issue:1, 2002
Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters.Journal of neuroscience research, , Jun-01, Volume: 68, Issue:5, 2002
Oligodendrocytes from neural stem cells express alpha-synuclein: increased numbers from presenilin 1 deficient mice.Neuroreport, , Jul-19, Volume: 13, Issue:10, 2002
Clusterin/apolipoprotein J is associated with cortical Lewy bodies: immunohistochemical study in cases with alpha-synucleinopathies.Acta neuropathologica, , Volume: 104, Issue:3, 2002
Multiple system atrophy: cellular and molecular pathology.Molecular pathology : MP, , Volume: 54, Issue:6, 2001
Analysis of the expression level of alpha-synuclein mRNA using postmortem brain samples from pathologically confirmed cases of multiple system atrophy.Acta neuropathologica, , Volume: 102, Issue:2, 2001
Depletion of cholinergic neurons of the medullary arcuate nucleus in multiple system atrophy.Autonomic neuroscience : basic & clinical, , Mar-23, Volume: 87, Issue:2-3, 2001
Alpha-synuclein and neurodegenerative diseases.Nature reviews. Neuroscience, , Volume: 2, Issue:7, 2001
[Alpha-synucleinopathies].Neurologia (Barcelona, Spain), , Volume: 16, Issue:4, 2001
Co-localization of alpha-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration.Acta neuropathologica, , Volume: 101, Issue:3, 2001
alpha-Synuclein forms a complex with transcription factor Elk-1.Journal of neurochemistry, , Volume: 77, Issue:1, 2001
Synucleinopathies: clinical and pathological implications.Archives of neurology, , Volume: 58, Issue:2, 2001
The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease.Journal of neurochemistry, , Volume: 76, Issue:1, 2001
Alpha-synuclein and Parkinson's disease.Cellular and molecular life sciences : CMLS, , Volume: 57, Issue:13-14, 2000
Depression in alpha-synucleinopathies: prevalence, pathophysiology and treatment.Journal of neural transmission. Supplementum, , Issue:60, 2000
The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.Annals of the New York Academy of Sciences, , Volume: 920, 2000
Multiple system atrophy/progressive supranuclear palsy: alpha-Synuclein, synphilin, tau, and APOE.Neurology, , Dec-26, Volume: 55, Issue:12, 2000
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions.Science (New York, N.Y.), , Nov-03, Volume: 290, Issue:5493, 2000
The pathogenesis of multiple system atrophy: past, present, and future.Movement disorders : official journal of the Movement Disorder Society, , Volume: 15, Issue:5, 2000
Immunohistochemical and biochemical studies demonstrate a distinct profile of alpha-synuclein permutations in multiple system atrophy.Journal of neuropathology and experimental neurology, , Volume: 59, Issue:9, 2000
Characterisation of isolated alpha-synuclein filaments from substantia nigra of Parkinson's disease brain.Neuroscience letters, , Oct-06, Volume: 292, Issue:2, 2000
Late-onset neurodegenerative diseases--the role of protein insolubility.Journal of anatomy, , Volume: 196 ( Pt 4), 2000
The expression of alpha-, beta-, and gamma-synucleins in olfactory mucosa from patients with and without neurodegenerative diseases.Experimental neurology, , Volume: 160, Issue:2, 1999
Alpha-synuclein immunoisolation of glial inclusions from multiple system atrophy brain tissue reveals multiprotein components.Journal of neurochemistry, , Volume: 73, Issue:5, 1999
Multiple system atrophy: a sporadic synucleinopathy.Brain pathology (Zurich, Switzerland), , Volume: 9, Issue:4, 1999
Widespread alterations of alpha-synuclein in multiple system atrophy.The American journal of pathology, , Volume: 155, Issue:4, 1999
The genetics of disorders with synuclein pathology and parkinsonism.Human molecular genetics, , Volume: 8, Issue:10, 1999
No mutation in the entire coding region of the alpha-synuclein gene in pathologically confirmed cases of multiple system atrophy.Neuroscience letters, , Jul-30, Volume: 270, Issue:2, 1999
Accumulation of alpha-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy.Acta neuropathologica, , Volume: 96, Issue:5, 1998
Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein.Annals of neurology, , Volume: 44, Issue:3, 1998
Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies.Neuroscience letters, , Jul-31, Volume: 251, Issue:3, 1998
Multiple-system atrophy: a new alpha-synuclein disease?Lancet (London, England), , Aug-15, Volume: 352, Issue:9127, 1998
Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy.Neuroscience letters, , Jun-19, Volume: 249, Issue:2-3, 1998
Alpha synuclein in neurodegenerative disorders: murderer or accomplice?Nature medicine, , Volume: 4, Issue:7, 1998
Alpha-synuclein in the cerebrospinal fluid differentiates synucleinopathies (Parkinson Disease, dementia with Lewy bodies, multiple system atrophy) from Alzheimer disease.Alzheimer disease and associated disorders, , Volume: 26, Issue:3
Alpha-synuclein binding to rab3a in multiple system atrophy.Neuroscience letters, , Volume: 380, Issue:1-2
SUMO-1 marks subdomains within glial cytoplasmic inclusions of multiple system atrophy.Neuroscience letters, , Volume: 381, Issue:1-2
Feasibility and considerations of epsin2 as a candidate target for multiple system atrophy treatment.Expert opinion on therapeutic targets, , Volume: 27, Issue:11
Transplantation of Adipose-Derived Stem Cells Alleviates Striatal Degeneration in a Transgenic Mouse Model for Multiple System Atrophy.Cell transplantation, , Volume: 29
Genetic deletion of Polo-like kinase 2 reduces alpha-synuclein serine-129 phosphorylation in presynaptic terminals but not Lewy bodies.The Journal of biological chemistry, , Volume: 296
Abundant glial alpha-synuclein pathology in a case without overt clinical symptoms.Clinical neuropathology, , Volume: 26, Issue:6
Detection of Dermal Alpha-Synuclein Deposits as a Biomarker for Parkinson's Disease.Journal of Parkinson's disease, , Volume: 11, Issue:3
Multiple system atrophy of the cerebellar type (MSA-C) with concomitant beta-amyloid and tau pathology.Clinical neuropathology, , Volume: 32, Issue:4
Alpha-synuclein Levels in the Differential Diagnosis of Lewy Bodies Dementia and Other Neurodegenerative Disorders: A Meta-analysis.Alzheimer disease and associated disorders, , Volume: 34, Issue:3
Cognitive and neuropsychiatric profile of the synucleinopathies: Parkinson disease, dementia with Lewy bodies, and multiple system atrophy.Alzheimer disease and associated disorders, , Volume: 23, Issue:4
Ashwagandha- Withania somnifera (L.) Dunal as a multipotent neuroprotective remedy for genetically induced motor dysfunction and cellular toxicity in human neurodegenerative disease models of Drosophila.Journal of ethnopharmacology, , Jan-10, Volume: 318, Issue:Pt A, 2024
Impact of sex on neuroimmune contributions to Parkinson's disease.Brain research bulletin, , Volume: 199, 2023
Tau seeds occur before earliest Alzheimer's changes and are prevalent across neurodegenerative diseases.Acta neuropathologica, , Volume: 146, Issue:1, 2023
The Endo-lysosomal System in Parkinson's Disease: Expanding the Horizon.Journal of molecular biology, , 06-15, Volume: 435, Issue:12, 2023
Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.Molecular neurodegeneration, , 05-02, Volume: 18, Issue:1, 2023
[no title available]Oxidative medicine and cellular longevity, , Volume: 2023, 2023
Pathophysiology and Neuroimmune Interactions Underlying Parkinson's Disease and Traumatic Brain Injury.International journal of molecular sciences, , Apr-13, Volume: 24, Issue:8, 2023
MALAT1 Mediates Mediators of inflammation, , Volume: 2023, 2023
Alpha Synuclein: Neurodegeneration and Inflammation.International journal of molecular sciences, , Mar-21, Volume: 24, Issue:6, 2023
Gene Expression Profiling as a Novel Diagnostic Tool for Neurodegenerative Disorders.International journal of molecular sciences, , Mar-17, Volume: 24, Issue:6, 2023
Chemical Synthesis of Alpha-Synuclein Proteins via Solid-Phase Peptide Synthesis and Native Chemical Ligation.Chemistry (Weinheim an der Bergstrasse, Germany), , Jun-13, Volume: 29, Issue:33, 2023
Biochemical study of the effect of mesenchymal stem cells-derived exosome versus L-Dopa in experimentally induced Parkinson's disease in rats.Molecular and cellular biochemistry, , Volume: 478, Issue:12, 2023
Vinpocetine prevents rotenone-induced Parkinson disease motor and non-motor symptoms through attenuation of oxidative stress, neuroinflammation and α-synuclein expressions in rats.Neurotoxicology, , Volume: 96, 2023
Cannabidiol Recovers Dopaminergic Neuronal Damage Induced by Reserpine or α-synuclein in Caenorhabditis elegans.Neurochemical research, , Volume: 48, Issue:8, 2023
Activation of ROS-PERK-TFEB by filbertone ameliorates neurodegenerative diseases via enhancing the autophagy-lysosomal pathway.The Journal of nutritional biochemistry, , Volume: 118, 2023
Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions.Proceedings of the National Academy of Sciences of the United States of America, , 03-28, Volume: 120, Issue:13, 2023
Recent Advances in the Treatment of Genetic Forms of Parkinson's Disease: Hype or Hope?Cells, , 02-27, Volume: 12, Issue:5, 2023
Unravelling the destabilization potential of ellagic acid on α-synuclein fibrils using molecular dynamics simulations.Physical chemistry chemical physics : PCCP, , Mar-15, Volume: 25, Issue:11, 2023
DJ-1 Molecular Chaperone Activity Depresses Tau Aggregation Propensity through Interaction with Monomers.Biochemistry, , 03-07, Volume: 62, Issue:5, 2023
Models of precision medicine for neurodegeneration.Handbook of clinical neurology, , Volume: 192, 2023
The alteration of intestinal mucosal α-synuclein expression and mucosal microbiota in Parkinson's disease.Applied microbiology and biotechnology, , Volume: 107, Issue:5-6, 2023
TNFRSF10B is involved in motor dysfunction in Parkinson's disease by regulating exosomal α-synuclein secretion from microglia.Journal of chemical neuroanatomy, , Volume: 129, 2023
Combined chronic copper exposure and aging lead to neurotoxicity in vivo.Neurotoxicology, , Volume: 95, 2023
The Ubiquitin Proteasome System as a Therapeutic Area in Parkinson's Disease.Neuromolecular medicine, , Volume: 25, Issue:3, 2023
Polymorphic Alpha-Synuclein Oligomers: Characterization and Differential Detection with Novel Corresponding Antibodies.Molecular neurobiology, , Volume: 60, Issue:5, 2023
Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein.Nature neuroscience, , Volume: 26, Issue:2, 2023
A review of the current research on in vivo and in vitro detection for alpha-synuclein: a biomarker of Parkinson's disease.Analytical and bioanalytical chemistry, , Volume: 415, Issue:9, 2023
The c-Abl inhibitor IkT-148009 suppresses neurodegeneration in mouse models of heritable and sporadic Parkinson's disease.Science translational medicine, , 01-18, Volume: 15, Issue:679, 2023
Potential Therapeutic Effects of Policosanol from Insect Wax on Caenorhabditis elegans Models of Parkinson's Disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 18, Issue:1-2, 2023
Folium Hibisci Mutabilis extract, a potent autophagy enhancer, exhibits neuroprotective properties in multiple models of neurodegenerative diseases.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 109, 2023
Role of α-synuclein in microglia: autophagy and phagocytosis balance neuroinflammation in Parkinson's disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.], , Volume: 72, Issue:3, 2023
Anti-α-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson's disease.Neurobiology of disease, , Volume: 177, 2023
Mitochondrial signaling on innate immunity activation in Parkinson disease.Current opinion in neurobiology, , Volume: 78, 2023
Proteostasis in Parkinson's disease: Recent development and possible implication in diagnosis and therapeutics.Ageing research reviews, , Volume: 84, 2023
Associations of phosphorylated tau pathology with whole-hemisphere ex vivo morphometry in 7 tesla MRI.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 19, Issue:6, 2023
An Update on Peripheral Blood Extracellular Vesicles as Biomarkers for Parkinson's Disease Diagnosis.Neuroscience, , 02-10, Volume: 511, 2023
Potential application of heat shock proteins as therapeutic targets in Parkinson's disease.Neurochemistry international, , Volume: 162, 2023
Targeting α-synuclein post-translational modifications in Parkinson's disease.Behavioural brain research, , 02-15, Volume: 439, 2023
Interlinked role of ASN, TDP-43 and Miro1 with parkinopathy: Focus on targeted approach against neuropathy in parkinsonism.Ageing research reviews, , Volume: 83, 2023
Microglia and astrocyte activation is region-dependent in the α-synuclein mouse model of Parkinson's disease.Glia, , Volume: 71, Issue:3, 2023
Single-Particle Analysis of the Interaction Between Molecules and Protein Aggregated Species by Dual-Color Time-Resolved Fluorescence Spectroscopy.Methods in molecular biology (Clifton, N.J.), , Volume: 2551, 2023
Benefits of Gut Microbiota Reconstitution by Beta 1,3-1,6 Glucans in Subjects with Autism Spectrum Disorder and Other Neurodegenerative Diseases.Journal of Alzheimer's disease : JAD, , Volume: 94, Issue:s1, 2023
Immunotherapeutic Approaches for the Treatment of Neurodegenerative Diseases: Challenges and Outcomes.CNS & neurological disorders drug targets, , Volume: 22, Issue:3, 2023
aSynPEP-DB: a database of biogenic peptides for inhibiting α-synuclein aggregation.Database : the journal of biological databases and curation, , 11-27, Volume: 2023, 2023
In Silico and In Vitro Study towards the Rational Design of 4,4'-Disarylbisthiazoles as a Selective α-Synucleinopathy Biomarker.International journal of molecular sciences, , Nov-17, Volume: 24, Issue:22, 2023
Characterization of Molecular Tweezer Binding on α-Synuclein with Native Top-Down Mass Spectrometry and Ion Mobility-Mass Spectrometry Reveals a Mechanism for Aggregation Inhibition.Journal of the American Society for Mass Spectrometry, , Dec-06, Volume: 34, Issue:12, 2023
Antagonizing pathological α-synuclein-mediated neurodegeneration by J24335 via the activation of immunoproteasome.Toxicology and applied pharmacology, , Dec-01, Volume: 480, 2023
Alpha-Synuclein-Specific Regulatory T Cells Ameliorate Parkinson's Disease Progression in Mice.International journal of molecular sciences, , Oct-16, Volume: 24, Issue:20, 2023
The Effects of Lipids on α-Synuclein Aggregation In Vitro.Biomolecules, , 10-02, Volume: 13, Issue:10, 2023
Tau accumulation in degradative organelles is associated to lysosomal stress.Scientific reports, , 10-21, Volume: 13, Issue:1, 2023
The interaction between alpha-synuclein and mitochondrial dysfunction in Parkinson's disease.Biophysical chemistry, , Volume: 303, 2023
Axonal Transport of Lysosomes Is Unaffected in Glucocerebrosidase-Inhibited iPSC-Derived Forebrain Neurons.eNeuro, , Volume: 10, Issue:10, 2023
Identifying the potential genes in alpha synuclein driving ferroptosis of Parkinson's disease.Scientific reports, , 10-06, Volume: 13, Issue:1, 2023
Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids.Nature, , Volume: 621, Issue:7980, 2023
Low-dose Cu exposure enhanced α-synuclein accumulation associates with mitochondrial impairments in mice model of Parkinson's disease.Toxicology letters, , Sep-15, Volume: 387, 2023
Association between SGK1 and α-synuclein in skeletal muscle in an MPTP-induced Parkinson's disease model.Neuroscience letters, , 09-25, Volume: 814, 2023
Tuning Hsp104 specificity to selectively detoxify α-synuclein.Molecular cell, , 09-21, Volume: 83, Issue:18, 2023
Heterotypic liquid-liquid phase separation of tau and α-synuclein: Implications for overlapping neuropathologies.Biochimica et biophysica acta. Proteins and proteomics, , 11-01, Volume: 1871, Issue:6, 2023
Effect of flavonoids on the destabilization of α-synuclein fibrils and their conversion to amorphous aggregate: A molecular dynamics simulation and experimental study.Biochimica et biophysica acta. Proteins and proteomics, , 11-01, Volume: 1871, Issue:6, 2023
Investigation of Inflammation in Lewy Body Dementia: A Systematic Scoping Review.International journal of molecular sciences, , Jul-28, Volume: 24, Issue:15, 2023
Omics Analyses in a Neural Stem Cell Model of Familial Parkinson's Disease.Advances in experimental medicine and biology, , Volume: 1423, 2023
Brain-Biomarker Changes in Body Fluids of Patients with Parkinson's Disease.International journal of molecular sciences, , Jun-30, Volume: 24, Issue:13, 2023
ARL6IP5 Ameliorates α-Synuclein Burden by Inducing Autophagy via Preventing Ubiquitination and Degradation of ATG12.International journal of molecular sciences, , Jun-22, Volume: 24, Issue:13, 2023
Development of an α-synuclein positron emission tomography tracer for imaging synucleinopathies.Cell, , 08-03, Volume: 186, Issue:16, 2023
Development of a hydroxyflavone-labelled 4554W peptide probe for monitoring αS aggregation.Scientific reports, , 07-06, Volume: 13, Issue:1, 2023
Seed Amplification Assay as a Diagnostic Tool in Newly-Diagnosed Parkinson's Disease.Journal of Parkinson's disease, , Volume: 13, Issue:5, 2023
Endocytic pathways of pathogenic protein aggregates in neurodegenerative diseases.Traffic (Copenhagen, Denmark), , Volume: 24, Issue:10, 2023
Unveiling How Hydroxytyrosol Destabilizes α-Syn Oligomers Using Molecular Simulations.The journal of physical chemistry. B, , 06-29, Volume: 127, Issue:25, 2023
The loss of function GBA1 c.231C > G mutation associated with Parkinson disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 130, Issue:7, 2023
Targeting Sigma-1 Receptor: A Promising Strategy in the Treatment of Parkinson's Disease.Neurochemical research, , Volume: 48, Issue:10, 2023
Intestinal infection triggers mitochondria-mediated α-synuclein pathology: relevance to Parkinson's disease.Cellular and molecular life sciences : CMLS, , May-30, Volume: 80, Issue:6, 2023
NF-κB/NLRP3 inflammasome axis and risk of Parkinson's disease in Type 2 diabetes mellitus: A narrative review and new perspective.Journal of cellular and molecular medicine, , Volume: 27, Issue:13, 2023
Microglia-specific knock-out of NF-κB/IKK2 increases the accumulation of misfolded α-synuclein through the inhibition of p62/sequestosome-1-dependent autophagy in the rotenone model of Parkinson's disease.Glia, , Volume: 71, Issue:9, 2023
Research Progress of α-Synuclein Aggregation Inhibitors for Potential Parkinson's Disease Treatment.Mini reviews in medicinal chemistry, , Volume: 23, Issue:20, 2023
Structures of tau and α-synuclein filaments from brains of patients with neurodegenerative diseases.Neurochemistry international, , Volume: 158, 2022
Skin alpha-synuclein deposit patterns: A predictor of Parkinson's disease subtypes.EBioMedicine, , Volume: 80, 2022
Novel insights into the role of circular RNAs in Parkinson disease: An emerging renaissance in the management of neurodegenerative diseases.Journal of neuroscience research, , Volume: 100, Issue:9, 2022
Beyond neurodegenerative diseases: α-synuclein in erythropoiesis.Hematology (Amsterdam, Netherlands), , Volume: 27, Issue:1, 2022
Treating Parkinson's Disease via Activation of BDNF/TrkB Signaling Pathways and Inhibition of Delta-Secretase.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 19, Issue:4, 2022
Brain atrophy in prodromal synucleinopathy is shaped by structural connectivity and gene expression.Brain : a journal of neurology, , 09-14, Volume: 145, Issue:9, 2022
Loss of GBA in zebrafish leads to dopaminergic neurodegeneration, but overexpression of α-synuclein does not further worsen degeneration.Neuroreport, , 05-04, Volume: 33, Issue:7, 2022
Cholecystokinin and glucagon-like peptide-1 analogues regulate intestinal tight junction, inflammation, dopaminergic neurons and α-synuclein accumulation in the colon of two Parkinson's disease mouse models.European journal of pharmacology, , Jul-05, Volume: 926, 2022
New Insights and Implications of Natural Killer Cells in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
Overlap between Central and Peripheral Transcriptomes in Parkinson's Disease but Not Alzheimer's Disease.International journal of molecular sciences, , May-06, Volume: 23, Issue:9, 2022
Targeting alpha-synuclein or tau for treating neurodegenerative movement disorders.Revue neurologique, , Volume: 178, Issue:5, 2022
Hytrin loaded polydopamine-serotonin nanohybrid induces IDH2 mediated neuroprotective effect to alleviate Parkinson's disease.Biomaterials advances, , Volume: 133, 2022
α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 101, 2022
Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43.Acta neuropathologica, , Volume: 143, Issue:6, 2022
Exploring the Role of Ubiquitin-Proteasome System in Parkinson's Disease.Molecular neurobiology, , Volume: 59, Issue:7, 2022
Design, Synthesis, and Biological Evaluation of Potent 20S Proteasome Activators for the Potential Treatment of α-Synucleinopathies.Journal of medicinal chemistry, , 05-12, Volume: 65, Issue:9, 2022
Reduction of the α-synuclein expression promotes slowing down early neuropathology development in the Journal of neurogenetics, , Volume: 36, Issue:1, 2022
7,8-Dihydroxyflavone ameliorates mitochondrial impairment and motor dysfunction in the α-synuclein 1-103 transgenic mice.Neurobiology of disease, , Volume: 169, 2022
The roles of HSP40/DNAJ protein family in neurodegenerative diseases.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, , Nov-25, Volume: 51, Issue:5, 2022
Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases.Progress in neurobiology, , Volume: 214, 2022
Inflammation promotes synucleinopathy propagation.Experimental & molecular medicine, , Volume: 54, Issue:12, 2022
Immune Response Modifications in the Genetic Forms of Parkinson's Disease: What Do We Know?International journal of molecular sciences, , Mar-23, Volume: 23, Issue:7, 2022
LncRNA HOTAIR promotes α-synuclein aggregation and apoptosis of SH-SY5Y cells by regulating miR-221-3p in Parkinson's disease.Experimental cell research, , 08-01, Volume: 417, Issue:1, 2022
α-Synuclein arginylation in the human brain.Translational neurodegeneration, , 04-08, Volume: 11, Issue:1, 2022
Monoclonal Antibodies in Neurodegenerative Disease May Work, But They Don't Help: A Perspective from Physicians.Journal of Parkinson's disease, , Volume: 12, Issue:8, 2022
Distribution of α-Synuclein Aggregation in the Peripheral Tissues.Neurochemical research, , Volume: 47, Issue:12, 2022
The Role of NEDD4 E3 Ubiquitin-Protein Ligases in Parkinson's Disease.Genes, , 03-14, Volume: 13, Issue:3, 2022
Ubiquitin-positive astrogliopathy clinically mimicking Parkinson's disease.Acta neuropathologica communications, , 11-14, Volume: 10, Issue:1, 2022
Glymphatic System Dysfunction and Sleep Disturbance May Contribute to the Pathogenesis and Progression of Parkinson's Disease.International journal of molecular sciences, , Oct-26, Volume: 23, Issue:21, 2022
Immune responses in the Parkinson's disease brain.Neurobiology of disease, , 06-15, Volume: 168, 2022
Propagation of tau and α-synuclein in the brain: therapeutic potential of the glymphatic system.Translational neurodegeneration, , 03-21, Volume: 11, Issue:1, 2022
[Role of fatty acid-binding protein 7 and novel therapeutic approach in synucleinopathies].Nihon yakurigaku zasshi. Folia pharmacologica Japonica, , Volume: 157, Issue:6, 2022
Celastrol Downmodulates Alpha-Synuclein-Specific T Cell Responses by Mediating Antigen Trafficking in Dendritic Cells.Frontiers in immunology, , Volume: 13, 2022
Association Between Pathophysiological Mechanisms of Diabetic Retinopathy and Parkinson's Disease.Cellular and molecular neurobiology, , Volume: 42, Issue:3, 2022
Synthesis and evaluation of novel radioiodinated phenylbenzofuranone derivatives as α-synuclein imaging probes.Bioorganic & medicinal chemistry letters, , 05-15, Volume: 64, 2022
[A role of human microbiota in the development of neurodegenerative diseases].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, , Volume: 122, Issue:10, 2022
Molecular Insights into the Misfolding and Dimerization Dynamics of the Full-Length α-Synuclein from Atomistic Discrete Molecular Dynamics Simulations.ACS chemical neuroscience, , 11-02, Volume: 13, Issue:21, 2022
Liquid-Liquid Phase Separation Promotes Protein Aggregation and Its Implications in Ferroptosis in Parkinson's Disease Dementia.Oxidative medicine and cellular longevity, , Volume: 2022, 2022
The Potential Role of Voltage-Dependent Anion Channel in the Treatment of Parkinson's Disease.Oxidative medicine and cellular longevity, , Volume: 2022, 2022
The Antioxidative Effects of Picein and Its Neuroprotective Potential: A Review of the Literature.Molecules (Basel, Switzerland), , Sep-21, Volume: 27, Issue:19, 2022
Neuroprotective Function of Rasagiline and Selegiline, Inhibitors of Type B Monoamine Oxidase, and Role of Monoamine Oxidases in Synucleinopathies.International journal of molecular sciences, , Sep-21, Volume: 23, Issue:19, 2022
Regulation by Different Types of Chaperones of Amyloid Transformation of Proteins Involved in the Development of Neurodegenerative Diseases.International journal of molecular sciences, , Mar-02, Volume: 23, Issue:5, 2022
Global, in situ analysis of the structural proteome in individuals with Parkinson's disease to identify a new class of biomarker.Nature structural & molecular biology, , Volume: 29, Issue:10, 2022
Smell deficits in COVID-19 and possible links with Parkinson's disease.International review of neurobiology, , Volume: 165, 2022
Pathophysiological significance of increased α-synuclein deposition in sympathetic nerves in Parkinson's disease: a post-mortem observational study.Translational neurodegeneration, , 03-08, Volume: 11, Issue:1, 2022
Progress in Parkinson's disease animal models of genetic defects: Characteristics and application.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 155, 2022
Gene therapy of yeast NDI1 on mitochondrial complex I dysfunction in rotenone-induced Parkinson's disease models in vitro and vivo.Molecular medicine (Cambridge, Mass.), , 03-07, Volume: 28, Issue:1, 2022
Regulation of Parkinson's disease-associated genes by Pumilio proteins and microRNAs in SH-SY5Y neuronal cells.PloS one, , Volume: 17, Issue:9, 2022
Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies.Cellular and molecular life sciences : CMLS, , Mar-04, Volume: 79, Issue:3, 2022
α-Syn overexpression, NRF2 suppression, and enhanced ferroptosis create a vicious cycle of neuronal loss in Parkinson's disease.Free radical biology & medicine, , 11-01, Volume: 192, 2022
Biomarkers Related to Synaptic Dysfunction to Discriminate Alzheimer's Disease from Other Neurological Disorders.International journal of molecular sciences, , Sep-16, Volume: 23, Issue:18, 2022
The role of lysosomal cathepsins in neurodegeneration: Mechanistic insights, diagnostic potential and therapeutic approaches.Biochimica et biophysica acta. Molecular cell research, , Volume: 1869, Issue:7, 2022
Central and Enteric Neuroprotective Effects by Eucommia ulmoides Extracts on Neurodegeneration in Rotenone-induced Parkinsonian Mouse.Acta medica Okayama, , Volume: 76, Issue:4, 2022
Distinct neurotoxic TDP-43 fibril polymorphs are generated by heterotypic interactions with α-Synuclein.The Journal of biological chemistry, , Volume: 298, Issue:11, 2022
Propagation of Parkinson's disease by extracellular vesicle production and secretion.Biochemical Society transactions, , 10-31, Volume: 50, Issue:5, 2022
Fenofibrate promotes neuroprotection in a model of rotenone-induced Parkinson's disease.Behavioural pharmacology, , 12-01, Volume: 33, Issue:8, 2022
The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity.Molecules (Basel, Switzerland), , Feb-15, Volume: 27, Issue:4, 2022
Detection of α-Synuclein-Specific T Cells in Parkinson's Disease.Methods in molecular biology (Clifton, N.J.), , Volume: 2574, 2022
Homozygous CADPS2 Mutations Cause Neurodegenerative Disease with Lewy Body-like Pathology in Parrots.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:12, 2022
Exploring the link between GBA1 mutations and Dementia with Lewy bodies, A mini-review.Neuroscience and biobehavioral reviews, , Volume: 141, 2022
Neuropathology of the Basal Ganglia in SNCA Transgenic Rat Model of Parkinson's Disease: Involvement of Parvalbuminergic Interneurons and Glial-Derived Neurotropic Factor.International journal of molecular sciences, , Sep-04, Volume: 23, Issue:17, 2022
Post-COVID-19 Parkinsonism and Parkinson's Disease Pathogenesis: The Exosomal Cargo Hypothesis.International journal of molecular sciences, , Aug-28, Volume: 23, Issue:17, 2022
Inhibition of α-synuclein aggregation by MT101-5 is neuroprotective in mouse models of Parkinson's disease.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 154, 2022
Characterization of molecular biomarkers in cerebrospinal fluid and serum of E46K-SNCA mutation carriers.Parkinsonism & related disorders, , Volume: 96, 2022
Neuroinflammation in Parkinson's Disease and its Treatment Opportunities.Balkan medical journal, , 09-09, Volume: 39, Issue:5, 2022
Living in α-syn: Tackling aggregates in Parkinson's disease.Neuron, , 02-02, Volume: 110, Issue:3, 2022
Examination of Abnormal Alpha-synuclein Aggregates in the Enteric Neural Plexus in Patients with Ulcerative Colitis.Journal of gastrointestinal and liver diseases : JGLD, , 09-15, Volume: 31, Issue:3, 2022
Skeletal Muscle is a Source of α-Synuclein with a Sarcolemmal Non-Lipid Raft Distribution.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , Aug-25, Volume: 56, Issue:4, 2022
Phosphorylation of endogenous α-synuclein induced by extracellular seeds initiates at the pre-synaptic region and spreads to the cell body.Scientific reports, , 01-21, Volume: 12, Issue:1, 2022
[Aggregation and spread of synuclein in Parkinson's disease].Medecine sciences : M/S, , Volume: 38, Issue:1, 2022
Analysis of the Biomarkers for Neurodegenerative Diseases in Aged Progranulin Deficient Mice.International journal of molecular sciences, , Jan-06, Volume: 23, Issue:2, 2022
Role of NLRP3 Inflammasome in Parkinson's Disease and Therapeutic Considerations.Journal of Parkinson's disease, , Volume: 12, Issue:7, 2022
Controlled Activation of TRPV1 Channels on Microglia to Boost Their Autophagy for Clearance of Alpha-Synuclein and Enhance Therapy of Parkinson's Disease.Advanced materials (Deerfield Beach, Fla.), , Volume: 34, Issue:11, 2022
Therapeutics in the Pipeline Targeting Pharmacological reviews, , Volume: 74, Issue:1, 2022
The Role of Amyloid-β, Tau, and α-Synuclein Proteins as Putative Blood Biomarkers in Patients with Cerebral Amyloid Angiopathy.Journal of Alzheimer's disease : JAD, , Volume: 89, Issue:3, 2022
A double-hit in vivo model of GBA viral microRNA-mediated downregulation and human alpha-synuclein overexpression demonstrates nigrostriatal degeneration.Neurobiology of disease, , Volume: 163, 2022
Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A): Could It Be a Promising Biomarker and Therapeutic Target in Parkinson's Disease?Molecular neurobiology, , Volume: 59, Issue:2, 2022
Phosphorylated α-synuclein in diluted human serum as a biomarker for Parkinson's disease.Biomedical journal, , Volume: 45, Issue:6, 2022
Phosphorylation of the aggregate-forming protein alpha-synuclein on serine-129 inhibits its DNA-bending properties.The Journal of biological chemistry, , Volume: 298, Issue:2, 2022
Angiotensin converting enzyme inhibitor captopril prevents neuronal overexpression of amyloid-beta and alpha-synuclein in Drosophila melanogaster genetic models of neurodegenerative diseases.Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, , Jun-30, Volume: 37, Issue:1, 2022
Mechanisms of NLRP3 activation and pathology during neurodegeneration.The international journal of biochemistry & cell biology, , Volume: 151, 2022
A new strategy to reconcile amyloid cross-seeding and amyloid prevention in a binary system of α-synuclein fragmental peptide and hIAPP.Protein science : a publication of the Protein Society, , Volume: 31, Issue:2, 2022
Functional Cooperation of α-Synuclein and Tau Is Essential for Proper Corticogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 09-14, Volume: 42, Issue:37, 2022
NXP031 prevents dopaminergic neuronal loss and oxidative damage in the AAV-WT-α-synuclein mouse model of Parkinson's disease.PloS one, , Volume: 17, Issue:7, 2022
Exogenous Tetranectin Alleviates Pre-formed-fibrils-induced Synucleinopathies in SH-SY5Y Cells by Activating the Plasminogen Activation System.Neurochemical research, , Volume: 47, Issue:10, 2022
A small molecule toll-like receptor antagonist rescues α-synuclein fibril pathology.The Journal of biological chemistry, , Volume: 298, Issue:8, 2022
Implications of intracellular protein degradation pathways in Parkinson's disease and therapeutics.Journal of neuroscience research, , Volume: 100, Issue:10, 2022
Role of platelet in Parkinson's disease: Insights into pathophysiology & theranostic solutions.Ageing research reviews, , Volume: 80, 2022
[Advances in Parkinson's disease induced by α-synuclein transmitted through the gut-brain axis].Sheng wu gong cheng xue bao = Chinese journal of biotechnology, , Jun-25, Volume: 38, Issue:6, 2022
Lysosomal functions and dysfunctions: Molecular and cellular mechanisms underlying Gaucher disease and its association with Parkinson disease.Advanced drug delivery reviews, , Volume: 187, 2022
Microglia in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
Novel Molecular Targets and Mechanisms for Neuroprotective Modulation in Neurodegenerative Disorders.Central nervous system agents in medicinal chemistry, , Volume: 22, Issue:2, 2022
Automated quantification of neuronal swellings in a preclinical rodent model of Parkinson's disease detects region-specific changes in pathology.Journal of neuroscience methods, , 08-01, Volume: 378, 2022
The immunology of Parkinson's disease.Seminars in immunopathology, , Volume: 44, Issue:5, 2022
Can Berberine Serve as a New Therapy for Parkinson's Disease?Neurotoxicity research, , Volume: 40, Issue:4, 2022
Pathophysiology of Parkinson's disease: Mitochondria, alpha-synuclein and much more….Revue neurologique, , Volume: 177, Issue:3, 2021
Proteasome Subunits Involved in Neurodegenerative Diseases.Archives of medical research, , Volume: 52, Issue:1, 2021
Microglia is associated with p-Tau aggregates in the olfactory bulb of patients with neurodegenerative diseases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 42, Issue:4, 2021
[no title available]Frontiers in cellular and infection microbiology, , Volume: 11, 2021
Roles of α‑synuclein in gastrointestinal microbiome dysbiosis‑related Parkinson's disease progression (Review).Molecular medicine reports, , Volume: 24, Issue:4, 2021
Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential.Acta neuropathologica, , Volume: 142, Issue:1, 2021
Genome-wide screen identifies curli amyloid fibril as a bacterial component promoting host neurodegeneration.Proceedings of the National Academy of Sciences of the United States of America, , 08-24, Volume: 118, Issue:34, 2021
Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 41, Issue:5, 2021
Update on the association between alpha-synuclein and tau with mitochondrial dysfunction: Implications for Parkinson's disease.The European journal of neuroscience, , Volume: 53, Issue:9, 2021
Pure autonomic failure and the differential diagnosis of autonomic peripheral neuropathies.Current opinion in neurology, , 10-01, Volume: 34, Issue:5, 2021
The magnetic-nanoparticle-assisted sensitive detection of nitrated α-syn in blood based on a sensitizing electrochemical layer.Nanoscale, , May-06, Volume: 13, Issue:17, 2021
The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model.Nature communications, , 08-11, Volume: 12, Issue:1, 2021
Parkinson's disease and the gut: Models of an emerging relationship.Acta biomaterialia, , 09-15, Volume: 132, 2021
Ultrasensitive techniques and protein misfolding amplification assays for biomarker-guided reconceptualization of Alzheimer's and other neurodegenerative diseases.Expert review of neurotherapeutics, , Volume: 21, Issue:9, 2021
Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein.Acta neuropathologica communications, , 04-08, Volume: 9, Issue:1, 2021
Amyloid Structural Changes Studied by Infrared Microspectroscopy in Bigenic Cellular Models of Alzheimer's Disease.International journal of molecular sciences, , Mar-26, Volume: 22, Issue:7, 2021
PGC-1s in the Spotlight with Parkinson's Disease.International journal of molecular sciences, , Mar-28, Volume: 22, Issue:7, 2021
SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration.Biochemical and biophysical research communications, , 05-21, Volume: 554, 2021
SGTA associates with intracellular aggregates in neurodegenerative diseases.Molecular brain, , 03-23, Volume: 14, Issue:1, 2021
Implementing Complementary Approaches to Shape the Mechanism of α-Synuclein Oligomerization as a Model of Amyloid Aggregation.Molecules (Basel, Switzerland), , Dec-24, Volume: 27, Issue:1, 2021
Biosensors in Parkinson's disease.Clinica chimica acta; international journal of clinical chemistry, , Volume: 518, 2021
α-Synuclein-induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms.Science advances, , Volume: 7, Issue:11, 2021
Alpha-Synuclein in the Regulation of Brain Endothelial and Perivascular Cells: Gaps and Future Perspectives.Frontiers in immunology, , Volume: 12, 2021
DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization.PLoS genetics, , Volume: 17, Issue:3, 2021
Neural-Induced Human Adipose Tissue-Derived Stem Cells Conditioned Medium Ameliorates Rotenone-Induced Toxicity in SH-SY5Y Cells.International journal of molecular sciences, , Feb-26, Volume: 22, Issue:5, 2021
[Therapeutic strategy for Parkinson's disease: targeting zinc-binding protein in astrocytes].Nihon yakurigaku zasshi. Folia pharmacologica Japonica, , Volume: 156, Issue:2, 2021
Ellagic Acid Prevents α-Synuclein Aggregation and Protects SH-SY5Y Cells from Aggregated α-Synuclein-Induced Toxicity via Suppression of Apoptosis and Activation of Autophagy.International journal of molecular sciences, , Dec-13, Volume: 22, Issue:24, 2021
LRRK2 Ablation Attenuates Αlpha-Synuclein-Induced Neuroinflammation Without Affecting Neurodegeneration or Neuropathology In Vivo.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 18, Issue:2, 2021
Clustered regularly interspaced short palindromic repeats as an advanced treatment for Parkinson's disease.Brain and behavior, , Volume: 11, Issue:8, 2021
Electrochemical biosensors for biometal-protein interactions in neurodegenerative diseases.Biosensors & bioelectronics, , May-01, Volume: 179, 2021
Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration.Molecular therapy : the journal of the American Society of Gene Therapy, , 05-05, Volume: 29, Issue:5, 2021
Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.Chemical reviews, , 02-24, Volume: 121, Issue:4, 2021
Prion Diseases: A Unique Transmissible Agent or a Model for Neurodegenerative Diseases?Biomolecules, , 02-02, Volume: 11, Issue:2, 2021
Evolutionary conservation and divergence of the human brain transcriptome.Genome biology, , 01-29, Volume: 22, Issue:1, 2021
α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 03-10, Volume: 41, Issue:10, 2021
Targeted proteolytic products of τ and α-synuclein in neurodegeneration.Essays in biochemistry, , 12-22, Volume: 65, Issue:7, 2021
From Posttranslational Modifications to Disease Phenotype: A Substrate Selection Hypothesis in Neurodegenerative Diseases.International journal of molecular sciences, , Jan-18, Volume: 22, Issue:2, 2021
Updates on the Genetics of Parkinson's Disease: Clinical Implications and Future Treatment.Acta neurologica Taiwanica, , Sep-30, Volume: 30(3), 2021
Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions.Acta neuropathologica communications, , 07-21, Volume: 9, Issue:1, 2021
(De)stabilization of Alpha-Synuclein Fibrillary Aggregation by Charged and Uncharged Surfactants.International journal of molecular sciences, , Nov-19, Volume: 22, Issue:22, 2021
Evidence of distinct α-synuclein strains underlying disease heterogeneity.Acta neuropathologica, , Volume: 142, Issue:1, 2021
α-Synuclein and neuronal membranes: Conformational flexibilities in health and disease.Chemistry and physics of lipids, , Volume: 235, 2021
Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds.Acta neuropathologica communications, , 11-24, Volume: 9, Issue:1, 2021
Reverse engineering Lewy bodies: how far have we come and how far can we go?Nature reviews. Neuroscience, , Volume: 22, Issue:2, 2021
Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities.Cell death and differentiation, , Volume: 28, Issue:2, 2021
Not a piece of junk anymore: Pseudogene T04B2.1 performs non-conventional regulatory role and modulates aggregation of α- synuclein and β-amyloid proteins in C. elegans.Biochemical and biophysical research communications, , 02-05, Volume: 539, 2021
[European journal of nuclear medicine and molecular imaging, , Volume: 48, Issue:6, 2021
Effects of the Toxic Metals Arsenite and Cadmium on α-Synuclein Aggregation In Vitro and in Cells.International journal of molecular sciences, , Oct-24, Volume: 22, Issue:21, 2021
[Neuroprotective treatment of idiopathic, genetic and atypical Parkinson's disease with alpha-synuclein-Pathology].Der Nervenarzt, , Volume: 92, Issue:12, 2021
Protein Aggregation Landscape in Neurodegenerative Diseases: Clinical Relevance and Future Applications.International journal of molecular sciences, , Jun-02, Volume: 22, Issue:11, 2021
Discovery of Hydroxybenzothiazole Urea Compounds as Multitargeted Agents Suppressing Major Cytotoxic Mechanisms in Neurodegenerative Diseases.ACS chemical neuroscience, , 11-17, Volume: 12, Issue:22, 2021
MicroRNA-7 Protects Against Neurodegeneration Induced by α-Synuclein Preformed Fibrils in the Mouse Brain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 18, Issue:4, 2021
Remodeling of the Fibrillation Pathway of α-Synuclein by Interaction with Antimicrobial Peptide LL-III.Chemistry (Weinheim an der Bergstrasse, Germany), , Aug-16, Volume: 27, Issue:46, 2021
Sharing is caring: The benefits of distributing protein aggregates among microglial networks.Neuron, , 10-20, Volume: 109, Issue:20, 2021
Astrocyte dysfunction in Parkinson's disease: from the perspectives of transmitted α-synuclein and genetic modulation.Translational neurodegeneration, , 10-18, Volume: 10, Issue:1, 2021
The Role of Cholesterol in α-Synuclein and Lewy Body Pathology in GBA1 Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:5, 2021
Neuroprotective effect of selumetinib on acrolein-induced neurotoxicity.Scientific reports, , 06-14, Volume: 11, Issue:1, 2021
LMK235, a small molecule inhibitor of HDAC4/5, protects dopaminergic neurons against neurotoxin- and α-synuclein-induced degeneration in cellular models of Parkinson's disease.Molecular and cellular neurosciences, , Volume: 115, 2021
Microglia esprit de corps: Sharing the burden of eliminating toxic aggregates.Cell, , 09-30, Volume: 184, Issue:20, 2021
Is Multiple System Atrophy a Prion-like Disorder?International journal of molecular sciences, , Sep-18, Volume: 22, Issue:18, 2021
N-γ-(L-glutamyl)-L-selenomethionine shows neuroprotective effects against Parkinson's disease associated with SKN-1/Nrf2 and TRXR-1 in Caenorhabditis elegans.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 92, 2021
Alternative platelet activation pathways and their role in neurodegenerative diseases.Neurobiology of disease, , Volume: 159, 2021
Biomarkers for neurodegenerative diseases.Nature medicine, , Volume: 27, Issue:6, 2021
Green Tea Epigallocatechin-3-gallate (EGCG) Targeting Protein Misfolding in Drug Discovery for Neurodegenerative Diseases.Biomolecules, , 05-20, Volume: 11, Issue:5, 2021
Glucocerebrosidase dysfunction in neurodegenerative disease.Essays in biochemistry, , 12-22, Volume: 65, Issue:7, 2021
Four Common Late-Life Cognitive Trajectories Patterns Associate with Replicable Underlying Neuropathologies.Journal of Alzheimer's disease : JAD, , Volume: 82, Issue:2, 2021
Insights into Lewy body disease from rare neurometabolic disorders.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 128, Issue:10, 2021
Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration.Nature communications, , 09-06, Volume: 12, Issue:1, 2021
Gut microbiota and metabolites of α-synuclein transgenic monkey models with early stage of Parkinson's disease.NPJ biofilms and microbiomes, , 09-02, Volume: 7, Issue:1, 2021
α-Synuclein Exhibits Differential Membrane Perturbation, Nucleation, and TLR2 Binding through Its Secondary Structure.ACS chemical neuroscience, , 12-16, Volume: 11, Issue:24, 2020
The Antiaggregative and Antiamyloidogenic Properties of Nanoparticles: A Promising Tool for the Treatment and Diagnostics of Neurodegenerative Diseases.Oxidative medicine and cellular longevity, , Volume: 2020, 2020
Toxic oligomers of the amyloidogenic HypF-N protein form pores in mitochondrial membranes.Scientific reports, , 10-20, Volume: 10, Issue:1, 2020
Developmental deficits and early signs of neurodegeneration revealed by PD patient derived dopamine neurons.Stem cell research, , Volume: 49, 2020
Natural and Synthetic Derivatives of Hydroxycinnamic Acid Modulating the Pathological Transformation of Amyloidogenic Proteins.Molecules (Basel, Switzerland), , Oct-12, Volume: 25, Issue:20, 2020
The interaction of α-synuclein and Tau: A molecular conspiracy in neurodegeneration?Seminars in cell & developmental biology, , Volume: 99, 2020
Double-stranded RNA-induced dopaminergic neuronal loss in the substantia nigra in the presence of Mac1 receptor.Biochemical and biophysical research communications, , 12-17, Volume: 533, Issue:4, 2020
Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns.Journal of neuropathology and experimental neurology, , 11-01, Volume: 79, Issue:11, 2020
Potential therapeutic role of fibroblast growth factor 21 in neurodegeneration: Evidence for ameliorating parkinsonism via silent information regulator 2 homolog 1 and implication for gene therapy.Neuropharmacology, , 12-15, Volume: 181, 2020
Targeting α-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance.Translational neurodegeneration, , 09-24, Volume: 9, Issue:1, 2020
Asparagine endopeptidase inhibitor protects against fenpropathrin-induced neurodegeneration via suppressing α-synuclein aggregation and neuroinflammation.European journal of pharmacology, , Dec-05, Volume: 888, 2020
Classifications of Neurodegenerative Disorders Using a Multiplex Blood Biomarkers-Based Machine Learning Model.International journal of molecular sciences, , Sep-21, Volume: 21, Issue:18, 2020
The role of the cellular prion protein in the uptake and toxic signaling of pathological neurodegenerative aggregates.Progress in molecular biology and translational science, , Volume: 175, 2020
O-GlcNAcylation inhibits the oligomerization of alpha-synuclein by declining intermolecular hydrogen bonds through a steric effect.Physical biology, , 12-01, Volume: 18, Issue:1, 2020
Mangosteen Pericarp and Its Bioactive Xanthones: Potential Therapeutic Value in Alzheimer's Disease, Parkinson's Disease, and Depression with Pharmacokinetic and Safety Profiles.International journal of molecular sciences, , Aug-27, Volume: 21, Issue:17, 2020
Defining the Protein Seeds of Neurodegeneration using Real-Time Quaking-Induced Conversion Assays.Biomolecules, , 08-25, Volume: 10, Issue:9, 2020
Iron-responsive-like elements and neurodegenerative ferroptosis.Learning & memory (Cold Spring Harbor, N.Y.), , Volume: 27, Issue:9, 2020
Discoidin Domain Receptor 1 is a therapeutic target for neurodegenerative diseases.Human molecular genetics, , 10-10, Volume: 29, Issue:17, 2020
Potential sources of interference with the highly sensitive detection and quantification of alpha-synuclein seeds by qRT-QuIC.FEBS open bio, , Volume: 10, Issue:5, 2020
The role of tissue biopsy as a biomarker in REM sleep behavior disorder.Sleep medicine reviews, , Volume: 51, 2020
Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration.Nature communications, , 03-13, Volume: 11, Issue:1, 2020
Somatic mutations in neurodegeneration: An update.Neurobiology of disease, , Volume: 144, 2020
Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases.Journal of neuropathology and experimental neurology, , 04-01, Volume: 79, Issue:4, 2020
A Curcumin Derivative Activates TFEB and Protects Against Parkinsonian Neurotoxicity International journal of molecular sciences, , Feb-22, Volume: 21, Issue:4, 2020
Tau and Alpha Synuclein Synergistic Effect in Neurodegenerative Diseases: When the Periphery Is the Core.International journal of molecular sciences, , Jul-16, Volume: 21, Issue:14, 2020
Endosomal-Lysosomal Processing of Neurodegeneration-Associated Proteins in Astrocytes.International journal of molecular sciences, , Jul-21, Volume: 21, Issue:14, 2020
The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration.Proceedings of the National Academy of Sciences of the United States of America, , 03-03, Volume: 117, Issue:9, 2020
Ropinirole silver nanocomposite attenuates neurodegeneration in the transgenic Drosophila melanogaster model of Parkinson's disease.Neuropharmacology, , 10-15, Volume: 177, 2020
[Emerging Disease-modifying Strategies Targeting α-synuclein in Parkinson's Disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:2, 2020
Intracerebral seeding of amyloid-β and tau pathology in mice: Factors underlying prion-like spreading and comparisons with α-synuclein.Neuroscience and biobehavioral reviews, , Volume: 112, 2020
Epitope region identification challenges of intrinsically disordered proteins in neurodegenerative diseases: Secondary structure dependence of α-synuclein on simulation techniques and force field parameters.Chemical biology & drug design, , Volume: 96, Issue:1, 2020
Prion-like properties of assembled TDP-43.Current opinion in neurobiology, , Volume: 61, 2020
Interactions between Soluble Species of β-Amyloid and α-Synuclein Promote Oligomerization while Inhibiting Fibrillization.Biochemistry, , 02-04, Volume: 59, Issue:4, 2020
PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins.Acta neuropathologica, , Volume: 139, Issue:3, 2020
In Vitro Conversion Assays Diagnostic for Neurodegenerative Proteinopathies.The journal of applied laboratory medicine, , 01-01, Volume: 5, Issue:1, 2020
General Aggregation-Induced Emission Probes for Amyloid Inhibitors with Dual Inhibition Capacity against Amyloid β-Protein and α-Synuclein.ACS applied materials & interfaces, , Jul-15, Volume: 12, Issue:28, 2020
Fasudil Promotes α-Synuclein Clearance in an AAV-Mediated α-Synuclein Rat Model of Parkinson's Disease by Autophagy Activation.Journal of Parkinson's disease, , Volume: 10, Issue:3, 2020
Crosstalk Between Alpha-Synuclein and Other Human and Non-Human Amyloidogenic Proteins: Consequences for Amyloid Formation in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 10, Issue:3, 2020
Advances in the development of imaging probes and aggregation inhibitors for alpha-synuclein.Acta pharmacologica Sinica, , Volume: 41, Issue:4, 2020
Experimental models of prion-like protein propagation.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 40, Issue:5, 2020
What is strain in neurodegenerative diseases?Cellular and molecular life sciences : CMLS, , Volume: 77, Issue:4, 2020
N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of Their Oligomers by the Proteasome Holoenzyme.Journal of molecular biology, , 01-17, Volume: 432, Issue:2, 2020
A systems biology approach for studying neurodegenerative diseases.Drug discovery today, , Volume: 25, Issue:7, 2020
The emerging role of α-synuclein truncation in aggregation and disease.The Journal of biological chemistry, , 07-24, Volume: 295, Issue:30, 2020
Ubiquitin biology in neurodegenerative disorders: From impairment to therapeutic strategies.Ageing research reviews, , Volume: 61, 2020
Evaluating the Effects of Grain of Isogenic Wheat Lines Differing in the Content of Anthocyanins in Mouse Models of Neurodegenerative Disorders.Nutrients, , Dec-18, Volume: 12, Issue:12, 2020
Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates.International journal of molecular sciences, , May-10, Volume: 21, Issue:9, 2020
On the role of the cellular prion protein in the uptake and signaling of pathological aggregates in neurodegenerative diseases.Prion, , Volume: 14, Issue:1, 2020
Cell-to-Cell Transmission of Tau and α-Synuclein.Trends in molecular medicine, , Volume: 26, Issue:10, 2020
Therapeutic genetic variation revealed in diverse Hsp104 homologs.eLife, , 12-15, Volume: 9, 2020
Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing α-synuclein and immune activation of Parkinson's disease.Science advances, , Volume: 6, Issue:50, 2020
Immunotherapies for Aging-Related Neurodegenerative Diseases-Emerging Perspectives and New Targets.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 17, Issue:3, 2020
Cerebrospinal fluid α-synuclein predicts neurodegeneration and clinical progression in non-demented elders.Translational neurodegeneration, , 11-23, Volume: 9, Issue:1, 2020
Role of Alcohol Drinking in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis.International journal of molecular sciences, , Mar-27, Volume: 21, Issue:7, 2020
Metformin protects rotenone-induced dopaminergic neurodegeneration by reducing lipid peroxidation.Pharmacological reports : PR, , Volume: 72, Issue:5, 2020
Protein transmission in neurodegenerative disease.Nature reviews. Neurology, , Volume: 16, Issue:4, 2020
Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration.Brain pathology (Zurich, Switzerland), , Volume: 29, Issue:1, 2019
Ammon's Horn 2 (CA2) of the Hippocampus: A Long-Known Region with a New Potential Role in Neurodegeneration.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, , Volume: 25, Issue:2, 2019
PET imaging of the influence of physiological and pathological α-synuclein on dopaminergic and serotonergic neurotransmission in mouse models.CNS neuroscience & therapeutics, , Volume: 25, Issue:1, 2019
AAA+ Protein-Based Technologies to Counter Neurodegenerative Disease.Biophysical journal, , 04-23, Volume: 116, Issue:8, 2019
Cell Responses to Extracellular α-Synuclein.Molecules (Basel, Switzerland), , 01-15, Volume: 24, Issue:2, 2019
Glycation of α-synuclein amplifies the binding with glyceraldehyde-3-phosphate dehydrogenase.International journal of biological macromolecules, , Apr-15, Volume: 127, 2019
New tricks of prolyl oligopeptidase inhibitors - A common drug therapy for several neurodegenerative diseases.Biochemical pharmacology, , Volume: 161, 2019
The prion-like spreading of α-synuclein: From in vitro to in vivo models of Parkinson's disease.Ageing research reviews, , Volume: 50, 2019
Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.Nature communications, , 04-18, Volume: 10, Issue:1, 2019
Neurodegenerative Disease-Related Proteins within the Epidermal Layer of the Human Skin.Journal of Alzheimer's disease : JAD, , Volume: 69, Issue:2, 2019
C. elegans as a Model for Synucleinopathies and Other Neurodegenerative Diseases: Tools and Techniques.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
Inflammasomes in neuroinflammatory and neurodegenerative diseases.EMBO molecular medicine, , Volume: 11, Issue:6, 2019
Single-Molecule FRET Detection of Early-Stage Conformations in α-Synuclein Aggregation.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
α-Synuclein and astrocytes: tracing the pathways from homeostasis to neurodegeneration in Lewy body disease.Acta neuropathologica, , Volume: 138, Issue:1, 2019
Nitroalkylation of α-Synuclein by Nitro-Oleic Acid: Implications for Parkinson's Disease.Advances in experimental medicine and biology, , Volume: 1127, 2019
Relationship Between Tau, β Amyloid and α-Synuclein Pathologies.Advances in experimental medicine and biology, , Volume: 1184, 2019
Early impairment of epigenetic pattern in neurodegeneration: Additional mechanisms behind pyrethroid toxicity.Experimental gerontology, , Volume: 124, 2019
Thymoquinone prevents neurodegeneration against MPTP in vivo and modulates α-synuclein aggregation in vitro.Neurochemistry international, , Volume: 128, 2019
Cerebrospinal Fluid and Plasma Biomarkers in Neurodegenerative Diseases.Journal of Alzheimer's disease : JAD, , Volume: 68, Issue:1, 2019
Patient-specific pluripotent stem cell-based Parkinson's disease models showing endogenous alpha-synuclein aggregation.BMB reports, , Volume: 52, Issue:6, 2019
Viral mimetic priming enhances α-synuclein-induced degeneration: Implications for Parkinson's disease.Brain, behavior, and immunity, , Volume: 80, 2019
Simultaneous tonic and phasic REM sleep without atonia best predicts early phenoconversion to neurodegenerative disease in idiopathic REM sleep behavior disorder.Sleep, , 09-06, Volume: 42, Issue:9, 2019
The Role of Antibodies and Their Receptors in Protection Against Ordered Protein Assembly in Neurodegeneration.Frontiers in immunology, , Volume: 10, 2019
[Exosomes and their roles in neurodegenerative diseases: from pathogenic, diagnostic and therapeutical perspectives].Sheng li xue bao : [Acta physiologica Sinica], , Jun-25, Volume: 71, Issue:3, 2019
Parkinson's disease-linked Proceedings of the National Academy of Sciences of the United States of America, , 03-19, Volume: 116, Issue:12, 2019
Local vulnerability and global connectivity jointly shape neurodegenerative disease propagation.PLoS biology, , Volume: 17, Issue:11, 2019
Small molecule modulator of aggrephagy regulates neuroinflammation to curb pathogenesis of neurodegeneration.EBioMedicine, , Volume: 50, 2019
Progressive supranuclear palsy, multiple system atrophy and corticobasal degeneration.Handbook of clinical neurology, , Volume: 165, 2019
[The Propagation Hypothesis of Prion-like Protein Agregates in Neurodegenerative Diseases].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 71, Issue:11, 2019
Prion-like propagation of α-synuclein in neurodegenerative diseases.Progress in molecular biology and translational science, , Volume: 168, 2019
[Prion-like Propagation of Pathological α-Synuclein in Vivo].Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, , Volume: 139, Issue:7, 2019
[Prion and Prion-like Proteins].Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, , Volume: 139, Issue:7, 2019
Cellular models of alpha-synuclein toxicity and aggregation.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Glial α-synuclein promotes neurodegeneration characterized by a distinct transcriptional program in vivo.Glia, , Volume: 67, Issue:10, 2019
Exploring the Peripheral Initiation of Parkinson's Disease in Animal Models.Neuron, , 08-21, Volume: 103, Issue:4, 2019
Modulation of Disordered Proteins with a Focus on Neurodegenerative Diseases and Other Pathologies.International journal of molecular sciences, , Mar-15, Volume: 20, Issue:6, 2019
Neuronal Proteins as Targets of 3-Hydroxykynurenine: Implications in Neurodegenerative Diseases.ACS chemical neuroscience, , 08-21, Volume: 10, Issue:8, 2019
Clinical and neuropathological differences between Parkinson's disease, Parkinson's disease dementia and dementia with Lewy bodies - current issues and future directions.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Mitochondrial degradation of amyloidogenic proteins - A new perspective for neurodegenerative diseases.Progress in neurobiology, , Volume: 181, 2019
Protein-DNA interaction: One step closer to understanding the mechanism of neurodegeneration.Journal of neuroscience research, , Volume: 97, Issue:4, 2019
Mechanistic Insight into the Binding Profile of DCVJ and α-Synuclein Fibril Revealed by Multiscale Simulations.ACS chemical neuroscience, , 01-16, Volume: 10, Issue:1, 2019
Pα-syn* mitotoxicity is linked to MAPK activation and involves tau phosphorylation and aggregation at the mitochondria.Neurobiology of disease, , Volume: 124, 2019
Rifampicin and Its Derivative Rifampicin Quinone Reduce Microglial Inflammatory Responses and Neurodegeneration Induced In Vitro by α-Synuclein Fibrillary Aggregates.Cells, , 07-25, Volume: 8, Issue:8, 2019
Fluid-based proteomics targeted on pathophysiological processes and pathologies in neurodegenerative diseases.Journal of neurochemistry, , Volume: 151, Issue:4, 2019
Dynamic behaviors of α-synuclein and tau in the cellular context: New mechanistic insights and therapeutic opportunities in neurodegeneration.Neurobiology of disease, , Volume: 132, 2019
Disease model organism for Parkinson disease: Drosophila melanogaster.BMB reports, , Volume: 52, Issue:4, 2019
Lysosomal enzyme activities as possible CSF biomarkers of synucleinopathies.Clinica chimica acta; international journal of clinical chemistry, , Volume: 495, 2019
Mitochondrial dysfunction in protein conformational disorders.Journal of genetics, , Volume: 97, Issue:3, 2018
Evolvability and Neurodegenerative Disease: Antagonistic Pleiotropy Phenomena Derived from Amyloid Aggregates.Journal of Parkinson's disease, , Volume: 8, Issue:3, 2018
α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies.Proceedings of the National Academy of Sciences of the United States of America, , 07-24, Volume: 115, Issue:30, 2018
Mitochondrial dysfunction and neurodegenerative proteinopathies: mechanisms and prospects for therapeutic intervention.Biochemical Society transactions, , 08-20, Volume: 46, Issue:4, 2018
The sulfation code for propagation of neurodegeneration.The Journal of biological chemistry, , 07-06, Volume: 293, Issue:27, 2018
α-Synuclein and Polyunsaturated Fatty Acids: Molecular Basis of the Interaction and Implication in Neurodegeneration.Molecules (Basel, Switzerland), , Jun-25, Volume: 23, Issue:7, 2018
Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated.Brain : a journal of neurology, , 07-01, Volume: 141, Issue:7, 2018
Linking Neuroinflammation and Neurodegeneration in Parkinson's Disease.Journal of immunology research, , Volume: 2018, 2018
Sensing α-Synuclein From the Outside via the Prion Protein: Implications for Neurodegeneration.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:11, 2018
[Targeting Transcellular Transport of α-Synuclein for Developing Disease-Modifying Therapies for Synucleinopathy].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 70, Issue:5, 2018
Chaperone AMPylation modulates aggregation and toxicity of neurodegenerative disease-associated polypeptides.Proceedings of the National Academy of Sciences of the United States of America, , 05-29, Volume: 115, Issue:22, 2018
Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology.Acta neuropathologica, , Volume: 136, Issue:3, 2018
Influence of Drug-Carrier Polymers on Alpha-Synucleinopathies: A Neglected Aspect in New Therapies Development.BioMed research international, , Volume: 2018, 2018
Cx3cr1-deficiency exacerbates alpha-synuclein-A53T induced neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease.Glia, , Volume: 66, Issue:8, 2018
Single-chain Fv Antibodies for Targeting Neurodegenerative Diseases.CNS & neurological disorders drug targets, , Volume: 17, Issue:9, 2018
Cre-dependent AAV vectors for highly targeted expression of disease-related proteins and neurodegeneration in the substantia nigra.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 32, Issue:8, 2018
Minimal neuropathologic diagnosis for brain banking in the normal middle-aged and aged brain and in neurodegenerative disorders.Handbook of clinical neurology, , Volume: 150, 2018
Le hazard ou la nécessité? Comorbid pathologies of neurodegenerative diseases.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 38, Issue:1, 2018
Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice.Proceedings of the National Academy of Sciences of the United States of America, , 02-13, Volume: 115, Issue:7, 2018
Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach.Brain : a journal of neurology, , 02-01, Volume: 141, Issue:2, 2018
Combined Active Humoral and Cellular Immunization Approaches for the Treatment of Synucleinopathies.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 01-24, Volume: 38, Issue:4, 2018
Toxic properties of microsome-associated alpha-synuclein species in mouse primary neurons.Neurobiology of disease, , Volume: 111, 2018
Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term.Acta neuropathologica, , Volume: 135, Issue:1, 2018
The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases.Journal of neuropathology and experimental neurology, , Jan-01, Volume: 77, Issue:1, 2018
Idiopathic REM sleep behaviour disorder and neurodegeneration - an update.Nature reviews. Neurology, , Volume: 14, Issue:1, 2018
Microarray analysis of an synthetic α-synuclein induced cellular model reveals the expression profile of long non-coding RNA in Parkinson's disease.Brain research, , Jan-01, Volume: 1678, 2018
RTP801 is a critical factor in the neurodegeneration process of A53T α-synuclein in a mouse model of Parkinson's disease under chronic restraint stress.British journal of pharmacology, , Volume: 175, Issue:4, 2018
Oligomer-prone E57K-mutant alpha-synuclein exacerbates integration deficit of adult hippocampal newborn neurons in transgenic mice.Brain structure & function, , Volume: 223, Issue:3, 2018
Internalization, axonal transport and release of fibrillar forms of alpha-synuclein.Neurobiology of disease, , Volume: 109, Issue:Pt B, 2018
A critical review of the prion hypothesis of human synucleinopathies.Cell and tissue research, , Volume: 373, Issue:1, 2018
Bicyclic bis-heteroaryl derivatives as inhibitors of the α-synuclein protein: a patent evaluation of WO2018138088A1.Expert opinion on therapeutic patents, , Volume: 28, Issue:12, 2018
Targeting of Disordered Proteins by Small Molecules in Neurodegenerative Diseases.Handbook of experimental pharmacology, , Volume: 245, 2018
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Effects of mild running on substantia nigra during early neurodegeneration.Journal of sports sciences, , Volume: 36, Issue:12, 2018
The dopamine transporter: An unrecognized nexus for dysfunctional peripheral immunity and signaling in Parkinson's Disease.Brain, behavior, and immunity, , Volume: 70, 2018
Mitochondrial Dynamics and Proteins Related to Neurodegenerative Diseases.Current protein & peptide science, , Volume: 19, Issue:9, 2018
Isolated nigral degeneration without pathological protein aggregation in autopsied brains with LRRK2 p.R1441H homozygous and heterozygous mutations.Acta neuropathologica communications, , 10-17, Volume: 6, Issue:1, 2018
Distinct α-Synuclein strains and implications for heterogeneity among α-Synucleinopathies.Neurobiology of disease, , Volume: 109, Issue:Pt B, 2018
Prions and Non-infectious Amyloids of Mammals - Similarities and Differences.Biochemistry. Biokhimiia, , Volume: 83, Issue:10, 2018
Predicting the location of the non-local contacts in α-synuclein.Biochimica et biophysica acta. Proteins and proteomics, , Volume: 1866, Issue:12, 2018
A53T Mutant Alpha-Synuclein Induces Tau-Dependent Postsynaptic Impairment Independently of Neurodegenerative Changes.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 11-07, Volume: 38, Issue:45, 2018
Alpha-synuclein alters differently gene expression of Sirts, PARPs and other stress response proteins: implications for neurodegenerative disorders.Molecular neurobiology, , Volume: 55, Issue:1, 2018
Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson's disease.Journal of neuroinflammation, , Aug-30, Volume: 15, Issue:1, 2018
Ceftriaxone Treatment for Neuronal Deficits: A Histological and MEMRI Study in a Rat Model of Dementia with Lewy Bodies.Behavioural neurology, , Volume: 2018, 2018
Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease.Acta neuropathologica, , Volume: 136, Issue:6, 2018
BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT.JCI insight, , 08-23, Volume: 3, Issue:16, 2018
Selective autophagy as a potential therapeutic target for neurodegenerative disorders.The Lancet. Neurology, , Volume: 17, Issue:9, 2018
Therapeutic implications of how TNF links apolipoprotein E, phosphorylated tau, α-synuclein, amyloid-β and insulin resistance in neurodegenerative diseases.British journal of pharmacology, , Volume: 175, Issue:20, 2018
Model Senescent Microglia Induce Disease Related Changes in α-Synuclein Expression and Activity.Biomolecules, , 08-01, Volume: 8, Issue:3, 2018
Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils.Journal of virology, , Jan-15, Volume: 91, Issue:2, 2017
Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species.Scientific reports, , 02-03, Volume: 7, 2017
Treatments and compositions targeting α-synuclein: a patent review (2010-2016).Expert opinion on therapeutic patents, , Volume: 27, Issue:4, 2017
Hederagenin and α-hederin promote degradation of proteins in neurodegenerative diseases and improve motor deficits in MPTP-mice.Pharmacological research, , Volume: 115, 2017
α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration.Neurobiology of disease, , Volume: 105, 2017
Novel approach for accurate tissue-based protein colocalization and proximity microscopy.Scientific reports, , 06-01, Volume: 7, Issue:1, 2017
Cellular Models for the Study of Prions.Cold Spring Harbor perspectives in medicine, , Feb-01, Volume: 7, Issue:2, 2017
Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity.Molecular neurodegeneration, , 05-29, Volume: 12, Issue:1, 2017
Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration.Brain : a journal of neurology, , Volume: 140, Issue:2, 2017
Validation of electrochemiluminescence assays for highly sensitive and reproducible quantification of α-synuclein in cerebrospinal fluid.Bioanalysis, , Volume: 9, Issue:8, 2017
Tell me your neighbors, and I will tell you what you are.Science translational medicine, , 02-08, Volume: 9, Issue:376, 2017
Therapeutic implication of autophagy in neurodegenerative diseases.BMB reports, , Volume: 50, Issue:7, 2017
Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.Neurochemistry international, , Volume: 109, 2017
Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation.Biochemical Society transactions, , 02-08, Volume: 45, Issue:1, 2017
Interactions of pathological proteins in neurodegenerative diseases.Acta neuropathologica, , Volume: 134, Issue:2, 2017
Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.Brain : a journal of neurology, , May-01, Volume: 140, Issue:5, 2017
Non-Amyloid PET Imaging Biomarkers for Neurodegeneration: Focus on Tau, Alpha-Synuclein and Neuroinflammation.Current Alzheimer research, , Volume: 14, Issue:2, 2017
Cerebrospinal Fluid Biomarkers of Neurodegeneration Are Decreased or Normal in Narcolepsy.Sleep, , Jan-01, Volume: 40, Issue:1, 2017
Focal Unilateral Traumatic brain injury Causes Delayed Neurodegenerative Changes in the Brain of Rats.Bulletin of experimental biology and medicine, , Volume: 164, Issue:2, 2017
Endogenous Alpha-Synuclein Protein Analysis from Human Brain Tissues Using Single-Molecule Pull-Down Assay.Analytical chemistry, , 12-19, Volume: 89, Issue:24, 2017
Proteinopathies and OXPHOS dysfunction in neurodegenerative diseases.The Journal of cell biology, , 12-04, Volume: 216, Issue:12, 2017
Anti-Parkinsonian effects of β-amyrin are regulated via LGG-1 involved autophagy pathway in Caenorhabditis elegans.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Dec-01, Volume: 36, 2017
Structural variants in SNCA gene and the implication to synucleinopathies.Current opinion in genetics & development, , Volume: 44, 2017
Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases.Molecular neurodegeneration, , 10-23, Volume: 12, Issue:1, 2017
Comparison of the in vivo induction and transmission of α-synuclein pathology by mutant α-synuclein fibril seeds in transgenic mice.Human molecular genetics, , 12-15, Volume: 26, Issue:24, 2017
Alpha-synucleinopathies.Handbook of clinical neurology, , Volume: 145, 2017
Concepts and classification of neurodegenerative diseases.Handbook of clinical neurology, , Volume: 145, 2017
Prion-like transmission of α-synuclein pathology in the context of an NFL null background.Neuroscience letters, , Nov-20, Volume: 661, 2017
Getting in charge of β-synuclein fibrillation.The Journal of biological chemistry, , 09-29, Volume: 292, Issue:39, 2017
Glycation, Glycolysis, and Neurodegenerative Diseases: Is There Any Connection?Biochemistry. Biokhimiia, , Volume: 82, Issue:8, 2017
Gene Expression Analysis Reveals Genes Common to Cerebral Malaria and Neurodegenerative Disorders.The Journal of infectious diseases, , 09-15, Volume: 216, Issue:6, 2017
Phosphoproteome-based kinase activity profiling reveals the critical role of MAP2K2 and PLK1 in neuronal autophagy.Autophagy, , Volume: 13, Issue:11, 2017
Protein aggregation and neurodegeneration in prototypical neurodegenerative diseases: Examples of amyloidopathies, tauopathies and synucleinopathies.Progress in neurobiology, , Volume: 155, 2017
Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration.Nature neuroscience, , Volume: 20, Issue:11, 2017
Protein arginylation targets alpha synuclein, facilitates normal brain health, and prevents neurodegeneration.Scientific reports, , 09-12, Volume: 7, Issue:1, 2017
E46K α-synuclein pathological mutation causes cell-autonomous toxicity without altering protein turnover or aggregation.Proceedings of the National Academy of Sciences of the United States of America, , 09-26, Volume: 114, Issue:39, 2017
Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy.Acta neuropathologica communications, , 01-13, Volume: 5, Issue:1, 2017
MultiTEP platform-based DNA vaccines for alpha-synucleinopathies: preclinical evaluation of immunogenicity and therapeutic potency.Neurobiology of aging, , Volume: 59, 2017
Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways.Cell systems, , 02-22, Volume: 4, Issue:2, 2017
Small-molecule PET Tracers for Imaging Proteinopathies.Seminars in nuclear medicine, , Volume: 47, Issue:5, 2017
Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates.Scientific reports, , 08-09, Volume: 7, Issue:1, 2017
Quantitative proteomics in A30P*A53T α-synuclein transgenic mice reveals upregulation of Sel1l.PloS one, , Volume: 12, Issue:8, 2017
Diagnosis, disease notification, and management of rapid eye movement (REM) sleep behavior disorder.Rinsho shinkeigaku = Clinical neurology, , 02-25, Volume: 57, Issue:2, 2017
Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form.Neurobiology of disease, , Volume: 106, 2017
Physico-Pathologic Mechanisms Involved in Neurodegeneration: Misfolded Protein-Plasma Membrane Interactions.Neuron, , Jul-05, Volume: 95, Issue:1, 2017
Triptolide Promotes the Clearance of α-Synuclein by Enhancing Autophagy in Neuronal Cells.Molecular neurobiology, , Volume: 54, Issue:3, 2017
Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species.BMC biology, , 07-03, Volume: 15, Issue:1, 2017
Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation.Brain research bulletin, , Volume: 133, 2017
Human cyclophilin 40 unravels neurotoxic amyloids.PLoS biology, , Volume: 15, Issue:6, 2017
Extracts from two ubiquitous Mediterranean plants ameliorate cellular and animal models of neurodegenerative proteinopathies.Neuroscience letters, , 01-18, Volume: 638, 2017
Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders.Pharmacology & therapeutics, , Volume: 172, 2017
Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice.Molecular neurodegeneration, , 01-03, Volume: 12, Issue:1, 2017
Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain.Acta neuropathologica communications, , 06-23, Volume: 5, Issue:1, 2017
Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases.EMBO molecular medicine, , Volume: 9, Issue:1, 2017
Auxilin Underlies Progressive Locomotor Deficits and Dopaminergic Neuron Loss in a Drosophila Model of Parkinson's Disease.Cell reports, , 01-31, Volume: 18, Issue:5, 2017
Medicinal chemistry advances in neurodegenerative disease therapy: part 2.Future medicinal chemistry, , Volume: 9, Issue:10, 2017
(123)I-meta-iodobenzylguanidine (MIBG) cardiac scintigraphy in α-synucleinopathies.Ageing research reviews, , Volume: 30, 2016
[The Prion-like Mechanism in Neurodegenerative Diseases-Current Studies and Future Prospects].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 68, Issue:10, 2016
Shared and Distinct Patterns of Oligodendroglial Response in α-Synucleinopathies and Tauopathies.Journal of neuropathology and experimental neurology, , 12-01, Volume: 75, Issue:12, 2016
Lysosomal storage disorders: 4 big questions.Nature, , 09-22, Volume: 537, Issue:7621, 2016
Editorial overview: Neurobiology of disease.Current opinion in neurobiology, , Volume: 36, 2016
Neurodegenerative disorders: Novel CSF assay for α-synucleinopathies.Nature reviews. Neurology, , Volume: 12, Issue:10, 2016
Alpha-Synuclein, a Novel Viral Restriction Factor Hiding in Plain Sight.DNA and cell biology, , Volume: 35, Issue:11, 2016
[Iron accumulation and neurodegenerative diseases].Nihon rinsho. Japanese journal of clinical medicine, , Volume: 74, Issue:7, 2016
Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 07-20, Volume: 36, Issue:29, 2016
From the Cover: Arsenic Induces Accumulation of α-Synuclein: Implications for Synucleinopathies and Neurodegeneration.Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 153, Issue:2, 2016
Is age-related failure of metabolic reprogramming a principal mediator in idiopathic Parkinson's disease? Implications for treatment and inverse cancer risk.Medical hypotheses, , Volume: 93, 2016
Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration.The Journal of clinical investigation, , 08-01, Volume: 126, Issue:8, 2016
Neurodegeneration in tauopathies and synucleinopathies.Revue neurologique, , Volume: 172, Issue:11, 2016
Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease.Acta neuropathologica communications, , 06-23, Volume: 4, Issue:1, 2016
Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.Neuron, , 07-06, Volume: 91, Issue:1, 2016
Amelioration of neuronal cell death in a spontaneous obese rat model by dietary restriction through modulation of ubiquitin proteasome system.The Journal of nutritional biochemistry, , Volume: 33, 2016
Engineering therapeutic protein disaggregases.Molecular biology of the cell, , 05-15, Volume: 27, Issue:10, 2016
Lysines, Achilles' heel in alpha-synuclein conversion to a deadly neuronal endotoxin.Ageing research reviews, , Volume: 26, 2016
Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 05-04, Volume: 36, Issue:18, 2016
A First Tetraplex Assay for the Simultaneous Quantification of Total α-Synuclein, Tau, β-Amyloid42 and DJ-1 in Human Cerebrospinal Fluid.PloS one, , Volume: 11, Issue:4, 2016
Activation of Mitochondrial Complex II-Dependent Respiration Is Beneficial for α-Synucleinopathies.Molecular neurobiology, , Volume: 53, Issue:7, 2016
The utility of α-synuclein as biofluid marker in neurodegenerative diseases: a systematic review of the literature.Biomarkers in medicine, , Volume: 10, Issue:1, 2016
New insights into cellular α-synuclein homeostasis in health and disease.Current opinion in neurobiology, , Volume: 36, 2016
Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
High expression of α-synuclein in damaged mitochondria with PLA2G6 dysfunction.Acta neuropathologica communications, , Mar-30, Volume: 4, 2016
[Assemblies of alpha-synuclein: do different strains exist?].Medecine sciences : M/S, , Volume: 32, Issue:3, 2016
Immunotherapeutic Approaches Targeting Amyloid-β, α-Synuclein, and Tau for the Treatment of Neurodegenerative Disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 13, Issue:1, 2016
A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration.Nature reviews. Neuroscience, , Volume: 17, Issue:4, 2016
Interferon-β may ameliorate synucleinopathy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:4, 2016
Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein.Methods in molecular biology (Clifton, N.J.), , Volume: 1345, 2016
Glia and alpha-synuclein in neurodegeneration: A complex interaction.Neurobiology of disease, , Volume: 85, 2016
Protein Partners of α-Synuclein in Health and Disease.Brain pathology (Zurich, Switzerland), , Volume: 26, Issue:3, 2016
Exocytosis and Spreading of Normal and Aberrant α-Synuclein.Brain pathology (Zurich, Switzerland), , Volume: 26, Issue:3, 2016
α-Synuclein in Neurodegeneration-A Good Protein that may go Bad.Brain pathology (Zurich, Switzerland), , Volume: 26, Issue:3, 2016
ɑ-Synuclein strains and the variable pathologies of synucleinopathies.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Cdk5 at crossroads of protein oligomerization in neurodegenerative diseases: facts and hypotheses.Journal of neurochemistry, , Volume: 136, Issue:2, 2016
Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease.Science translational medicine, , 12-07, Volume: 8, Issue:368, 2016
Alpha-synuclein propagation: New insights from animal models.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Formaldehyde-fixed brain tissue from spontaneously ill α-synuclein transgenic mice induces fatal α-synucleinopathy in transgenic hosts.Acta neuropathologica, , Volume: 129, Issue:1, 2015
Seeding and propagation of lesions in neurodegenerative diseases: a new paradigm.Bulletin de l'Academie nationale de medecine, , Volume: 199, Issue:6, 2015
Novel therapeutic approaches in multiple system atrophy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 25, Issue:1, 2015
[Histopathological and immunohistochemical study of spinal cord tissues in neurodegenerative diseases].Zhonghua bing li xue za zhi = Chinese journal of pathology, , Volume: 44, Issue:8, 2015
How many biomarkers to discriminate neurodegenerative dementia?Critical reviews in clinical laboratory sciences, , Volume: 52, Issue:6, 2015
Propagation of prions causing synucleinopathies in cultured cells.Proceedings of the National Academy of Sciences of the United States of America, , Sep-01, Volume: 112, Issue:35, 2015
Validation of a commercially available enzyme-linked immunoabsorbent assay for the quantification of human α-Synuclein in cerebrospinal fluid.Journal of immunological methods, , Volume: 426, 2015
Neurodegenerative changes in the brainstem and olfactory bulb in people older than 50 years old: a descriptive study.Arquivos de neuro-psiquiatria, , Volume: 73, Issue:7, 2015
Identification of novel autophagic Radix Polygalae fraction by cell membrane chromatography and UHPLC-(Q)TOF-MS for degradation of neurodegenerative disease proteins.Scientific reports, , Nov-24, Volume: 5, 2015
Cysteine cathepsins are essential in lysosomal degradation of α-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , Jul-28, Volume: 112, Issue:30, 2015
Enduring deficits in memory and neuronal pathology after blast-induced traumatic brain injury.Scientific reports, , Nov-05, Volume: 5, 2015
Validation of a quantitative cerebrospinal fluid alpha-synuclein assay in a European-wide interlaboratory study.Neurobiology of aging, , Volume: 36, Issue:9, 2015
Assessment of the degree of asymmetry of pathological features in neurodegenerative diseases. What is the significance for brain banks?Journal of neural transmission (Vienna, Austria : 1996), , Volume: 122, Issue:10, 2015
Electroacupuncture remediates glial dysfunction and ameliorates neurodegeneration in the astrocytic α-synuclein mutant mouse model.Journal of neuroinflammation, , May-28, Volume: 12, 2015
Histological evidence of chronic traumatic encephalopathy in a large series of neurodegenerative diseases.Acta neuropathologica, , Volume: 130, Issue:6, 2015
Nrf2 inducer and cncC overexpression attenuates neurodegeneration due to α-synuclein in Drosophila.Biochemistry and cell biology = Biochimie et biologie cellulaire, , Volume: 93, Issue:4, 2015
The use of cerebrospinal fluid and neuropathologic studies in neuropsychiatry practice and research.The Psychiatric clinics of North America, , Volume: 38, Issue:2, 2015
Curcumin Pyrazole and its derivative (N-(3-Nitrophenylpyrazole) Curcumin inhibit aggregation, disrupt fibrils and modulate toxicity of Wild type and Mutant α-Synuclein.Scientific reports, , May-18, Volume: 5, 2015
Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy.Cell reports, , Oct-27, Volume: 13, Issue:4, 2015
Sirtuins and proteolytic systems: implications for pathogenesis of synucleinopathies.Biomolecules, , May-04, Volume: 5, Issue:2, 2015
Unveiling transient protein-protein interactions that modulate inhibition of alpha-synuclein aggregation by beta-synuclein, a pre-synaptic protein that co-localizes with alpha-synuclein.Scientific reports, , Oct-19, Volume: 5, 2015
A bacterial metabolite induces glutathione-tractable proteostatic damage, proteasomal disturbances, and PINK1-dependent autophagy in C. elegans.Cell death & disease, , Oct-15, Volume: 6, 2015
Role of the unfolded protein response in the pathogenesis of Parkinson's disease.Acta neurobiologiae experimentalis, , Volume: 75, Issue:1, 2015
Characterization of spheroids in hereditary diffuse leukoencephalopathy with axonal spheroids.Journal of the neurological sciences, , May-15, Volume: 352, Issue:1-2, 2015
Post-mortem assessment of the short and long-term effects of the trophic factor neurturin in patients with α-synucleinopathies.Neurobiology of disease, , Volume: 78, 2015
Seeking a mechanism for the toxicity of oligomeric α-synuclein.Biomolecules, , Mar-25, Volume: 5, Issue:2, 2015
Neuropathic alterations of the myenteric plexus neurons following subacute intraperitoneal administration of salsolinol.Folia histochemica et cytobiologica, , Volume: 53, Issue:1, 2015
Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.Experimental & molecular medicine, , Mar-13, Volume: 47, 2015
Dopamine Transporter Activity Is Modulated by α-Synuclein.The Journal of biological chemistry, , Dec-04, Volume: 290, Issue:49, 2015
Role of Different Alpha-Synuclein Strains in Synucleinopathies, Similarities with other Neurodegenerative Diseases.Journal of Parkinson's disease, , Volume: 5, Issue:2, 2015
Effect of α-synuclein on membrane permeability and synaptic transmission: a clue to neurodegeneration?Journal of neurochemistry, , Volume: 132, Issue:6, 2015
Patterns of Tau and α-Synuclein Pathology in the Visual System.Journal of Parkinson's disease, , Volume: 5, Issue:2, 2015
Control tissue in brain banking: the importance of thorough neuropathological assessment.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 122, Issue:7, 2015
Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons.Neurobiology of disease, , Volume: 82, 2015
Trafficking and degradation pathways in pathogenic conversion of prions and prion-like proteins in neurodegenerative diseases.Virus research, , Sep-02, Volume: 207, 2015
Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization.Angewandte Chemie (International ed. in English), , Feb-16, Volume: 54, Issue:8, 2015
Gaucher-related synucleinopathies: the examination of sporadic neurodegeneration from a rare (disease) angle.Progress in neurobiology, , Volume: 125, 2015
Differential calcium alterations in animal models of neurodegenerative disease: Reversal by FK506.Neuroscience, , Dec-03, Volume: 310, 2015
α-Synuclein modifies mutant huntingtin aggregation and neurotoxicity in Drosophila.Human molecular genetics, , Apr-01, Volume: 24, Issue:7, 2015
The synergistic effect between β-amyloid(1-42) and α-synuclein on the synapses dysfunction in hippocampal neurons.Journal of chemical neuroanatomy, , Volume: 63, 2015
Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.Proceedings of the National Academy of Sciences of the United States of America, , Sep-22, Volume: 112, Issue:38, 2015
Alpha-synuclein and tau: teammates in neurodegeneration?Molecular neurodegeneration, , Oct-29, Volume: 9, 2014
Interactions between calcium and alpha-synuclein in neurodegeneration.Biomolecules, , Aug-14, Volume: 4, Issue:3, 2014
Prion-like mechanisms in the pathogenesis of tauopathies and synucleinopathies.Current neurology and neuroscience reports, , Volume: 14, Issue:11, 2014
Concomitant accumulation of α-synuclein and TDP-43 in a patient with corticobasal degeneration.Journal of neurology, , Volume: 261, Issue:11, 2014
New α- and γ-synuclein immunopathological lesions in human brain.Acta neuropathologica communications, , Sep-11, Volume: 2, 2014
Molecular imaging insights into neurodegeneration: focus on α-synuclein radiotracers.Journal of nuclear medicine : official publication, Society of Nuclear Medicine, , Volume: 55, Issue:9, 2014
Immunolocalization of human alpha-synuclein in the Thy1-aSyn ("Line 61") transgenic mouse line.Neuroscience, , Sep-26, Volume: 277, 2014
Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins.Disease models & mechanisms, , Volume: 7, Issue:10, 2014
Analysis of dopaminergic neuronal dysfunction in genetic and toxin-induced models of Parkinson's disease in Drosophila.Journal of neurochemistry, , Volume: 131, Issue:3, 2014
Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice.Neurobiology of aging, , Volume: 35, Issue:11, 2014
Protective role of DNJ-27/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases.Antioxidants & redox signaling, , Jan-10, Volume: 20, Issue:2, 2014
Preventing α-synuclein aggregation: the role of the small heat-shock molecular chaperone proteins.Biochimica et biophysica acta, , Volume: 1842, Issue:9, 2014
Catecholamine autotoxicity. Implications for pharmacology and therapeutics of Parkinson disease and related disorders.Pharmacology & therapeutics, , Volume: 144, Issue:3, 2014
Interplay between HDAC6 and its interacting partners: essential roles in the aggresome-autophagy pathway and neurodegenerative diseases.DNA and cell biology, , Volume: 33, Issue:9, 2014
Abrogation of α-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats.Proceedings of the National Academy of Sciences of the United States of America, , Jun-24, Volume: 111, Issue:25, 2014
Prions: generation and spread versus neurotoxicity.The Journal of biological chemistry, , Jul-18, Volume: 289, Issue:29, 2014
A bacteriophage capsid protein provides a general amyloid interaction motif (GAIM) that binds and remodels misfolded protein assemblies.Journal of molecular biology, , Jun-26, Volume: 426, Issue:13, 2014
PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology.Brain : a journal of neurology, , Volume: 137, Issue:Pt 5, 2014
ATP6V0C knockdown in neuroblastoma cells alters autophagy-lysosome pathway function and metabolism of proteins that accumulate in neurodegenerative disease.PloS one, , Volume: 9, Issue:4, 2014
The NOX1/4 inhibitor GKT136901 as selective and direct scavenger of peroxynitrite.Current medicinal chemistry, , Volume: 21, Issue:3, 2014
Protein folding and misfolding in the neurodegenerative disorders: a review.Revue neurologique, , Volume: 170, Issue:3, 2014
Evidence of native α-synuclein conformers in the human brain.The Journal of biological chemistry, , Mar-14, Volume: 289, Issue:11, 2014
[REM sleep behavior disorder as a prodromal stage of α-synucleinopathies: symptoms, epidemiology, pathophysiology, diagnosis and therapy].Der Nervenarzt, , Volume: 85, Issue:1, 2014
Role of lipid peroxide in the neurodegenerative disorders.Sub-cellular biochemistry, , Volume: 77, 2014
Predictive atomic resolution descriptions of intrinsically disordered hTau40 and α-synuclein in solution from NMR and small angle scattering.Structure (London, England : 1993), , Feb-04, Volume: 22, Issue:2, 2014
Neurodegenerative disease: Yeast cells reveal new target for Parkinson's disease.Nature reviews. Drug discovery, , Volume: 13, Issue:1, 2014
Argyrophilic grain disease as a neurodegenerative substrate in late-onset schizophrenia and delusional disorders.European archives of psychiatry and clinical neuroscience, , Volume: 264, Issue:4, 2014
Over-expression of an inactive mutant cathepsin D increases endogenous alpha-synuclein and cathepsin B activity in SH-SY5Y cells.Journal of neurochemistry, , Volume: 128, Issue:6, 2014
RTCB-1 mediates neuroprotection via XBP-1 mRNA splicing in the unfolded protein response pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-26, Volume: 34, Issue:48, 2014
Neuropathology of partial PGC-1α deficiency recapitulates features of mitochondrial encephalopathies but not of neurodegenerative diseases.Neuro-degenerative diseases, , Volume: 12, Issue:4, 2013
Toxicity of extracellular secreted alpha-synuclein: Its role in nitrosative stress and neurodegeneration.Neurochemistry international, , Volume: 62, Issue:5, 2013
Oxidation and nitration of α-synuclein and their implications in neurodegenerative diseases.Archives of biochemistry and biophysics, , Volume: 533, Issue:1-2, 2013
Neurodegeneration-associated protein fragments as short-lived substrates of the N-end rule pathway.Molecular cell, , Apr-25, Volume: 50, Issue:2, 2013
[Neurotoxicity of pesticides: its relationship with neurodegenerative diseases].Medecine sciences : M/S, , Volume: 29, Issue:3, 2013
[Multiple functions of Gh/transglutaminase 2].Nihon yakurigaku zasshi. Folia pharmacologica Japonica, , Volume: 141, Issue:4, 2013
Propagating sticky matters: an update on "prion-like" templated misfolding in neurodegenerative disorders.Brain pathology (Zurich, Switzerland), , Volume: 23, Issue:3, 2013
Assessing neurodegenerative phenotypes in Drosophila dopaminergic neurons by climbing assays and whole brain immunostaining.Journal of visualized experiments : JoVE, , Apr-24, Issue:74, 2013
Prion-like propagation of protein aggregation and related therapeutic strategies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 10, Issue:3, 2013
Alpha-synuclein expression patterns in the colonic submucosal plexus of the aging Fischer 344 rat: implications for biopsies in aging and neurodegenerative disorders?Neurogastroenterology and motility, , Volume: 25, Issue:9, 2013
The glial marker YKL-40 is decreased in synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:13, 2013
Pressure-temperature folding landscape in proteins involved in neurodegenerative diseases and cancer.Biophysical chemistry, , Dec-15, Volume: 183, 2013
Neurodegenerative disease: can synucleinopathy and tauopathy be identified during life?Nature reviews. Neurology, , Volume: 9, Issue:8, 2013
The diagnostic utility of cerebrospinal fluid alpha-synuclein analysis in dementia with Lewy bodies - a systematic review and meta-analysis.Parkinsonism & related disorders, , Volume: 19, Issue:10, 2013
The role of α-synuclein in neurodegenerative diseases: from molecular pathways in disease to therapeutic approaches.Current Alzheimer research, , Volume: 10, Issue:6, 2013
Treatment implications of the altered cytokine-insulin axis in neurodegenerative disease.Biochemical pharmacology, , Oct-01, Volume: 86, Issue:7, 2013
The Lewy body in Parkinson's disease and related neurodegenerative disorders.Molecular neurobiology, , Volume: 47, Issue:2, 2013
Clinical markers of early nigrostriatal neurodegeneration in idiopathic rapid eye movement sleep behavior disorder.Sleep medicine, , Volume: 14, Issue:11, 2013
The potential prognostic role of cardiovascular autonomic failure in α-synucleinopathies.European journal of neurology, , Volume: 20, Issue:2, 2013
Alpha-synuclein post-translational modifications as potential biomarkers for Parkinson disease and other synucleinopathies.Molecular & cellular proteomics : MCP, , Volume: 12, Issue:12, 2013
Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathies.Acta neuropathologica communications, , Dec-05, Volume: 1, 2013
Molecular chaperones, α-synuclein, and neurodegeneration.Molecular neurobiology, , Volume: 47, Issue:2, 2013
α-Synuclein posttranslational modification and alternative splicing as a trigger for neurodegeneration.Molecular neurobiology, , Volume: 47, Issue:2, 2013
The role of crowded physiological environments in prion and prion-like protein aggregation.International journal of molecular sciences, , Oct-25, Volume: 14, Issue:11, 2013
Targeting the chameleon: a focused look at α-synuclein and its roles in neurodegeneration.Molecular neurobiology, , Volume: 47, Issue:2, 2013
The role of glia in α-synucleinopathies.Molecular neurobiology, , Volume: 47, Issue:2, 2013
α-Synuclein elevation in human neurodegenerative diseases: experimental, pathogenetic, and therapeutic implications.Molecular neurobiology, , Volume: 47, Issue:2, 2013
Werner coordination chemistry and neurodegeneration.Chemical Society reviews, , Feb-21, Volume: 42, Issue:4, 2013
Self-propagation of pathogenic protein aggregates in neurodegenerative diseases.Nature, , Sep-05, Volume: 501, Issue:7465, 2013
The neuroendocrine protein 7B2 suppresses the aggregation of neurodegenerative disease-related proteins.The Journal of biological chemistry, , Jan-11, Volume: 288, Issue:2, 2013
Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells.International journal of molecular sciences, , Nov-15, Volume: 14, Issue:11, 2013
Synaptic dysfunction in synucleinopathies.CNS & neurological disorders drug targets, , Volume: 12, Issue:8, 2013
The many faces of α-synuclein: from structure and toxicity to therapeutic target.Nature reviews. Neuroscience, , Volume: 14, Issue:1, 2013
Manganese exposure induces α-synuclein aggregation in the frontal cortex of non-human primates.Toxicology letters, , Mar-13, Volume: 217, Issue:3, 2013
Neurodegenerative diseases: quantitative predictions of protein-RNA interactions.RNA (New York, N.Y.), , Volume: 19, Issue:2, 2013
Single-chain fragment variable passive immunotherapies for neurodegenerative diseases.International journal of molecular sciences, , Sep-17, Volume: 14, Issue:9, 2013
Movement disorders in 2012: Advancing research towards novel therapeutic approaches.Nature reviews. Neurology, , Volume: 9, Issue:2, 2013
The function of α-synuclein.Neuron, , Sep-18, Volume: 79, Issue:6, 2013
Curcumin ameliorates the neurodegenerative pathology in A53T α-synuclein cell model of Parkinson's disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 8, Issue:1, 2013
α-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity.The Journal of biological chemistry, , Mar-15, Volume: 288, Issue:11, 2013
Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.Science (New York, N.Y.), , Nov-22, Volume: 342, Issue:6161, 2013
Immunotherapy for neurodegenerative diseases: focus on α-synucleinopathies.Pharmacology & therapeutics, , Volume: 138, Issue:3, 2013
A powerful yeast model to investigate the synergistic interaction of α-synuclein and tau in neurodegeneration.PloS one, , Volume: 8, Issue:2, 2013
L-NAME cotreatment did prevent neither mitochondrial impairment nor behavioral abnormalities in adult Wistar rats treated with vitamin A supplementation.Fundamental & clinical pharmacology, , Volume: 26, Issue:4, 2012
α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases.Journal of neurochemistry, , Volume: 120, Issue:3, 2012
Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons.Acta neuropathologica, , Volume: 123, Issue:5, 2012
Interaction between pathogenic proteins in neurodegenerative disorders.Journal of cellular and molecular medicine, , Volume: 16, Issue:6, 2012
Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons.Neurobiology of disease, , Volume: 45, Issue:3, 2012
Head injury, α-synuclein Rep1, and Parkinson's disease.Annals of neurology, , Volume: 71, Issue:1, 2012
Emerging neurotoxic mechanisms in environmental factors-induced neurodegeneration.Neurotoxicology, , Volume: 33, Issue:4, 2012
Long-term polarization of microglia upon α-synuclein overexpression in nonhuman primates.Neuroscience, , Apr-19, Volume: 208, 2012
Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.Human molecular genetics, , Jun-01, Volume: 21, Issue:11, 2012
Phosphorylated α-synuclein as a potential biomarker for Parkinson's disease and related disorders.Expert review of molecular diagnostics, , Volume: 12, Issue:2, 2012
Regional deficiencies in chaperone-mediated autophagy underlie α-synuclein aggregation and neurodegeneration.Neurobiology of disease, , Volume: 46, Issue:3, 2012
Membrane pores in the pathogenesis of neurodegenerative disease.Progress in molecular biology and translational science, , Volume: 107, 2012
Protein quality control in neurodegenerative disease.Progress in molecular biology and translational science, , Volume: 107, 2012
Autophagic adapter protein NBR1 is localized in Lewy bodies and glial cytoplasmic inclusions and is involved in aggregate formation in α-synucleinopathy.Acta neuropathologica, , Volume: 124, Issue:2, 2012
Systemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human α-synuclein under oligodendrocyte promoter: implications for multiple system atrophy.Acta neuropathologica, , Volume: 124, Issue:1, 2012
Detection of α-synuclein aggregates by fluorescence microscopy.Rejuvenation research, , Volume: 15, Issue:2, 2012
Prion-like spread of protein aggregates in neurodegeneration.The Journal of experimental medicine, , May-07, Volume: 209, Issue:5, 2012
[Role of septin cytoskeleton in dopaminergic neurotransmission and neurodegeneration].Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, , Volume: 32, Issue:1, 2012
Common features at the start of the neurodegeneration cascade.PLoS biology, , Volume: 10, Issue:5, 2012
[The role of proteins in neurodegenerative disease].Postepy higieny i medycyny doswiadczalnej (Online), , Apr-16, Volume: 66, 2012
Protein degradation pathways in Parkinson's disease: curse or blessing.Acta neuropathologica, , Volume: 124, Issue:2, 2012
Overexpression of parkin ameliorates dopaminergic neurodegeneration induced by 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.PloS one, , Volume: 7, Issue:6, 2012
Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with α-synuclein at the single molecule level.Molecular neurodegeneration, , Jul-23, Volume: 7, 2012
Novel one-step immunoassays to quantify α-synuclein: applications for biomarker development and high-throughput screening.The Journal of biological chemistry, , Sep-28, Volume: 287, Issue:40, 2012
Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy.Molecular neurodegeneration, , Aug-14, Volume: 7, 2012
Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders.Archives of neurology, , Volume: 69, Issue:11, 2012
Endosomal sorting related protein CHMP2B is localized in Lewy bodies and glial cytoplasmic inclusions in α-synucleinopathy.Neuroscience letters, , Oct-03, Volume: 527, Issue:1, 2012
An intrinsically disordered region of the acetyltransferase p300 with similarity to prion-like domains plays a role in aggregation.PloS one, , Volume: 7, Issue:11, 2012
Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias.Brain : a journal of neurology, , Volume: 135, Issue:Pt 12, 2012
[Neurodegeneration and epigenetics].Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, , Volume: 32, Issue:5-6, 2012
Nanoprobing of α-synuclein misfolding and aggregation with atomic force microscopy.Nanomedicine : nanotechnology, biology, and medicine, , Volume: 7, Issue:2, 2011
Aberrant protein structure and diseases of the brain.Irish journal of medical science, , Volume: 180, Issue:1, 2011
Lipid classes and fatty acid patterns are altered in the brain of γ-synuclein null mutant mice.Lipids, , Volume: 46, Issue:2, 2011
Inducible dopaminergic glutathione depletion in an α-synuclein transgenic mouse model results in age-related olfactory dysfunction.Neuroscience, , Jan-13, Volume: 172, 2011
Insights into the thermodynamics of copper association with amyloid-β, α-synuclein and prion proteins.Metallomics : integrated biometal science, , Volume: 3, Issue:3, 2011
The role of α-synuclein in neurotransmission and synaptic plasticity.Journal of chemical neuroanatomy, , Volume: 42, Issue:4, 2011
Chaperoning the SNAREs: a role in preventing neurodegeneration?Nature cell biology, , Volume: 13, Issue:1, 2011
Interaction of prolyl oligopeptidase with α-synuclein.CNS & neurological disorders drug targets, , Volume: 10, Issue:3, 2011
Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease.Environmental health perspectives, , Volume: 119, Issue:6, 2011
Biochemical and morphological consequences of human α-synuclein expression in a mouse α-synuclein null background.The European journal of neuroscience, , Volume: 33, Issue:4, 2011
α-Synuclein in Parkinson disease and other neurodegenerative disorders.Clinical chemistry and laboratory medicine, , Volume: 49, Issue:3, 2011
Glycosaminoglycans, protein aggregation and neurodegeneration.Current protein & peptide science, , Volume: 12, Issue:3, 2011
Targeting oligomers in neurodegenerative disorders: lessons from α-synuclein, tau, and amyloid-β peptide.Journal of Alzheimer's disease : JAD, , Volume: 24 Suppl 2, 2011
Structures of segments of α-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation.Protein science : a publication of the Protein Society, , Volume: 20, Issue:6, 2011
Cerebrospinal fluid Tau/α-synuclein ratio in Parkinson's disease and degenerative dementias.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:8, 2011
SUMO and its role in human diseases.International review of cell and molecular biology, , Volume: 288, 2011
Parkinson disease: PD biomarkers-use of α-synuclein reaches new levels.Nature reviews. Neurology, , May-10, Volume: 7, Issue:6, 2011
Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse model.The Journal of neuroscience : the official journal of the Society for Neuroscience, , May-11, Volume: 31, Issue:19, 2011
Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts.Acta neuropathologica, , Volume: 121, Issue:6, 2011
Stress, allostatic load, catecholamines, and other neurotransmitters in neurodegenerative diseases.Endocrine regulations, , Volume: 45, Issue:2, 2011
Multiprotein deposits in neurodegenerative disorders: our experience in the tissue brain bank of Navarra.Anatomical record (Hoboken, N.J. : 2007), , Volume: 294, Issue:7, 2011
Toll-like receptor 4 promotes α-synuclein clearance and survival of nigral dopaminergic neurons.The American journal of pathology, , Volume: 179, Issue:2, 2011
Inflammation in the early stages of neurodegenerative pathology.Journal of neuroimmunology, , Sep-15, Volume: 238, Issue:1-2, 2011
E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment.The Journal of biological chemistry, , Oct-07, Volume: 286, Issue:40, 2011
Air pollution & the brain: Subchronic diesel exhaust exposure causes neuroinflammation and elevates early markers of neurodegenerative disease.Journal of neuroinflammation, , Aug-24, Volume: 8, 2011
Parallel manifestations of neuropathologies in the enteric and central nervous systems.Neurogastroenterology and motility, , Volume: 23, Issue:12, 2011
α-Synuclein stimulates a dopamine transporter-dependent chloride current and modulates the activity of the transporter.The Journal of biological chemistry, , Dec-23, Volume: 286, Issue:51, 2011
CSF levels of oligomeric alpha-synuclein and beta-amyloid as biomarkers for neurodegenerative disease.Integrative biology : quantitative biosciences from nano to macro, , Volume: 3, Issue:12, 2011
Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-16, Volume: 31, Issue:46, 2011
Interaction between α-synuclein and other proteins in neurodegenerative disorders.TheScientificWorldJournal, , Volume: 11, 2011
[Pathologic substrate of synucleinopathies. Introduction].Revista espanola de geriatria y gerontologia, , Volume: 46 Suppl 1, 2011
[Role of genetics in the etiology of synucleinopathies].Revista espanola de geriatria y gerontologia, , Volume: 46 Suppl 1, 2011
Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons.Molecular neurodegeneration, , Dec-13, Volume: 6, 2011
[Seed, aggregation and propagation of abnormal proteins could explain neurodegeneration?].Rinsho shinkeigaku = Clinical neurology, , Volume: 51, Issue:11, 2011
[Alpha-synuclein].Nihon rinsho. Japanese journal of clinical medicine, , Volume: 69 Suppl 8, 2011
Recurrent systemic infections with Streptococcus pneumoniae do not aggravate the course of experimental neurodegenerative diseases.Journal of neuroscience research, , Volume: 88, Issue:5, 2010
Converse modulation of toxic alpha-synuclein oligomers in living cells by N'-benzylidene-benzohydrazide derivates and ferric iron.Biochemical and biophysical research communications, , Jan-01, Volume: 391, Issue:1, 2010
Trichloroethylene induces dopaminergic neurodegeneration in Fisher 344 rats.Journal of neurochemistry, , Volume: 112, Issue:3, 2010
The effect of prolonged fixation time on immunohistochemical staining of common neurodegenerative disease markers.Journal of neuropathology and experimental neurology, , Volume: 69, Issue:1, 2010
Residue Glu83 plays a major role in negatively regulating alpha-synuclein amyloid formation.Biochemical and biophysical research communications, , Jan-15, Volume: 391, Issue:3, 2010
Prion-like mechanisms in neurodegenerative diseases.Nature reviews. Neuroscience, , Volume: 11, Issue:3, 2010
Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies.The Journal of biological chemistry, , Mar-19, Volume: 285, Issue:12, 2010
Protein coding of neurodegenerative dementias: the neuropathological basis of biomarker diagnostics.Acta neuropathologica, , Volume: 119, Issue:4, 2010
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-03, Volume: 30, Issue:9, 2010
Distinct region-specific alpha-synuclein oligomers in A53T transgenic mice: implications for neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-03, Volume: 30, Issue:9, 2010
Oligomeric alpha-synuclein and its role in neuronal death.IUBMB life, , Volume: 62, Issue:5, 2010
ASIP Outstanding Investigator Award Lecture. New approaches to the pathology and genetics of neurodegeneration.The American journal of pathology, , Volume: 176, Issue:5, 2010
Early aggregation steps in alpha-synuclein as measured by FCS and FRET: evidence for a contagious conformational change.Biophysical journal, , Apr-07, Volume: 98, Issue:7, 2010
Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases.Cell death and differentiation, , Volume: 17, Issue:11, 2010
[GSK-3beta: a central kinase for neurodegenerative diseases?].Medecine sciences : M/S, , Volume: 26, Issue:5, 2010
Multiple non-cell autonomous actions of alpha-synuclein in neurodegenerative diseases: Is there a direct link?Cell cycle (Georgetown, Tex.), , Jul-15, Volume: 9, Issue:14, 2010
Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity.Cell, , Aug-20, Volume: 142, Issue:4, 2010
Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases.The Journal of biological chemistry, , Nov-05, Volume: 285, Issue:45, 2010
Preparation and characterization of neurotoxic tau oligomers.Biochemistry, , Nov-30, Volume: 49, Issue:47, 2010
Antibody therapy in neurodegenerative disease.Reviews in the neurosciences, , Volume: 21, Issue:4, 2010
Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity.PloS one, , Nov-16, Volume: 5, Issue:11, 2010
Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration.PloS one, , Jun-03, Volume: 4, Issue:6, 2009
Leucine-rich repeat kinase 2 expression leads to aggresome formation that is not associated with alpha-synuclein inclusions.Journal of neuropathology and experimental neurology, , Volume: 68, Issue:7, 2009
Enhanced alpha-synuclein expression in human neurodegenerative diseases: pathogenetic and therapeutic implications.Current protein & peptide science, , Volume: 10, Issue:5, 2009
Trends in the molecular pathogenesis and clinical therapeutics of common neurodegenerative disorders.International journal of molecular sciences, , Jun-03, Volume: 10, Issue:6, 2009
The paradoxical cell biology of alpha-Synucle.Results and problems in cell differentiation, , Volume: 48, 2009
Neurobiology of cognitive disorders.Current opinion in psychiatry, , Volume: 22, Issue:6, 2009
On the mechanism of nonspecific inhibitors of protein aggregation: dissecting the interactions of alpha-synuclein with Congo red and lacmoid.Biochemistry, , Sep-08, Volume: 48, Issue:35, 2009
Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration.Proceedings of the National Academy of Sciences of the United States of America, , Aug-18, Volume: 106, Issue:33, 2009
Investigating bacterial sources of toxicity as an environmental contributor to dopaminergic neurodegeneration.PloS one, , Oct-06, Volume: 4, Issue:10, 2009
Neuropathology of non-Alzheimer degenerative disorders.International journal of clinical and experimental pathology, , Aug-25, Volume: 3, Issue:1, 2009
Neurodegeneration. Could they all be prion diseases?Science (New York, N.Y.), , Dec-04, Volume: 326, Issue:5958, 2009
Finding order within disorder: elucidating the structure of proteins associated with neurodegenerative disease.Future medicinal chemistry, , Volume: 1, Issue:3, 2009
Common key-signals in learning and neurodegeneration: focus on excito-amino acids, beta-amyloid peptides and alpha-synuclein.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 116, Issue:8, 2009
Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss?Neuroscience letters, , Feb-06, Volume: 450, Issue:3, 2009
Increased frequency of alpha-synuclein in the substantia nigra in human immunodeficiency virus infection.Journal of neurovirology, , Volume: 15, Issue:2, 2009
Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases.Biochimica et biophysica acta, , Volume: 1790, Issue:7, 2009
Nigral degeneration with inclusion body formation and behavioral changes in rats after proteasomal inhibition.Stereotactic and functional neurosurgery, , Volume: 87, Issue:2, 2009
Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies.The American journal of pathology, , Volume: 174, Issue:5, 2009
Alpha-Synuclein contributes to GSK-3beta-catalyzed Tau phosphorylation in Parkinson's disease models.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 23, Issue:9, 2009
[Pathology of basal ganglia in neurodegenerative diseases].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 61, Issue:4, 2009
Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction.Acta neuropathologica, , Volume: 117, Issue:6, 2009
On the mechanism of internalization of alpha-synuclein into microglia: roles of ganglioside GM1 and lipid raft.Journal of neurochemistry, , Volume: 110, Issue:1, 2009
Recent developments in multiple system atrophy.Journal of neurology, , Volume: 256, Issue:11, 2009
Nucleic acid induced protein aggregation and its role in biology and pathology.Frontiers in bioscience (Landmark edition), , 06-01, Volume: 14, Issue:13, 2009
Intrinsic disorder in proteins associated with neurodegenerative diseases.Frontiers in bioscience (Landmark edition), , 06-01, Volume: 14, Issue:14, 2009
Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders.Autoimmunity reviews, , Volume: 7, Issue:6, 2008
alpha-Synucleinopathy models and human neuropathology: similarities and differences.Acta neuropathologica, , Volume: 115, Issue:1, 2008
Autonomic dysfunction in RBD--what can it teach us about disease progression?Sleep medicine, , Volume: 9, Issue:5, 2008
How is protein aggregation in amyloidogenic diseases modulated by biological membranes?European biophysics journal : EBJ, , Volume: 37, Issue:3, 2008
Beer and bread to brains and beyond: can yeast cells teach us about neurodegenerative disease?Neuro-Signals, , Volume: 16, Issue:1, 2008
A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in alpha-synuclein transgenic C. elegans.Human molecular genetics, , Oct-01, Volume: 17, Issue:19, 2008
The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease.Proceedings of the National Academy of Sciences of the United States of America, , Jan-15, Volume: 105, Issue:2, 2008
Fitting neurological protein aggregation kinetic data via a 2-step, minimal/"Ockham's razor" model: the Finke-Watzky mechanism of nucleation followed by autocatalytic surface growth.Biochemistry, , Feb-26, Volume: 47, Issue:8, 2008
A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides.Nature neuroscience, , Volume: 11, Issue:3, 2008
Aggregopathy in neurodegenerative diseases: mechanisms and therapeutic implication.Neuro-degenerative diseases, , Volume: 5, Issue:6, 2008
The role of alpha-synuclein in neurodegenerative diseases: a potential target for new treatment strategies?Neuro-degenerative diseases, , Volume: 5, Issue:3-4, 2008
Characterization of antibodies that selectively detect alpha-synuclein in pathological inclusions.Acta neuropathologica, , Volume: 116, Issue:1, 2008
What determines the molecular composition of abnormal protein aggregates in neurodegenerative disease?Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 28, Issue:4, 2008
Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinson's disease.Glia, , Aug-15, Volume: 56, Issue:11, 2008
alpha-Synuclein protofibrils inhibit 26 S proteasome-mediated protein degradation: understanding the cytotoxicity of protein protofibrils in neurodegenerative disease pathogenesis.The Journal of biological chemistry, , Jul-18, Volume: 283, Issue:29, 2008
Biologic models of neurodegenerative disorders.Handbook of clinical neurology, , Volume: 89, 2008
Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease.Neuroscience letters, , Jul-11, Volume: 439, Issue:2, 2008
Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jul-23, Volume: 28, Issue:30, 2008
Neurofibrillary tau pathology modulated by genetic variation of alpha-synuclein.Annals of neurology, , Volume: 64, Issue:3, 2008
Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease.The Journal of clinical investigation, , Volume: 118, Issue:9, 2008
Insights into the effects of alpha-synuclein expression and proteasome inhibition on glutathione metabolism through a dynamic in silico model of Parkinson's disease: validation by cell culture data.Free radical biology & medicine, , Nov-01, Volume: 45, Issue:9, 2008
[Molecular neuropathology of Non-Alzheimer dementia].Der Pathologe, , Volume: 29, Issue:6, 2008
Enduring involvement of tau, beta-amyloid, alpha-synuclein, ubiquitin and TDP-43 pathology in the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam (ALS/PDC).Acta neuropathologica, , Volume: 116, Issue:6, 2008
Alpha-synuclein misfolding and neurodegenerative diseases.Current protein & peptide science, , Volume: 9, Issue:5, 2008
Is malfunction of the ubiquitin proteasome system the primary cause of alpha-synucleinopathies and other chronic human neurodegenerative disease?Biochimica et biophysica acta, , Volume: 1782, Issue:12, 2008
Modulation of alpha-synuclein expression in transgenic animals for modelling synucleinopathies--is the juice worth the squeeze?Neurotoxicity research, , Volume: 14, Issue:4, 2008
Metal catalyzed oxidation of alpha-synuclein--a role for oligomerization in pathology?Current Alzheimer research, , Volume: 5, Issue:6, 2008
[Recent progress and future direction of neurodegenerative disease research].Rinsho shinkeigaku = Clinical neurology, , Volume: 48, Issue:11, 2008
The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases.Acta neuropathologica, , Volume: 113, Issue:2, 2007
PINK1, a gene product of PARK6, accumulates in alpha-synucleinopathy brains.Journal of neurology, neurosurgery, and psychiatry, , Volume: 78, Issue:6, 2007
[Animal models of neurodegenerative diseases].Medecine sciences : M/S, , Volume: 23, Issue:2, 2007
Metals ions and neurodegeneration.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, , Volume: 20, Issue:3-4, 2007
Adult-onset neurodegeneration with brain iron accumulation and cortical alpha-synuclein and tau pathology: a distinct clinicopathological entity.Archives of neurology, , Volume: 64, Issue:2, 2007
Predominant neuritic pathology induced by viral overexpression of alpha-synuclein in cell culture.Cellular and molecular neurobiology, , Volume: 27, Issue:4, 2007
alpha-Synuclein and its disease-related mutants interact differentially with the microtubule protein tau and associate with the actin cytoskeleton.Neurobiology of disease, , Volume: 26, Issue:3, 2007
Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.Journal of neurochemistry, , Volume: 101, Issue:6, 2007
Expanding insights on the involvement of endoplasmic reticulum stress in Parkinson's disease.Antioxidants & redox signaling, , Volume: 9, Issue:5, 2007
DNA induces folding in alpha-synuclein: understanding the mechanism using chaperone property of osmolytes.Archives of biochemistry and biophysics, , Aug-01, Volume: 464, Issue:1, 2007
Immunohistochemical localization of NUB1, a synphilin-1-binding protein, in neurodegenerative disorders.Acta neuropathologica, , Volume: 114, Issue:4, 2007
Alpha-synuclein pathology in the olfactory pathways of dementia patients.Journal of anatomy, , Volume: 211, Issue:1, 2007
Determination of alpha-synuclein concentration in human plasma using ELISA.Scandinavian journal of clinical and laboratory investigation, , Volume: 67, Issue:4, 2007
Classical Parkinson disease versus Parkinson complex--reflections against staging and in favour of heterogeneity.European journal of neurology, , Volume: 14, Issue:7, 2007
Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation.Journal of neurochemistry, , Volume: 103, Issue:1, 2007
Medicine. The yin-yang of sirtuins.Science (New York, N.Y.), , Jul-27, Volume: 317, Issue:5837, 2007
Correlation of amyloid fibril beta-structure with the unfolded state of alpha-synuclein.Chembiochem : a European journal of chemical biology, , Sep-24, Volume: 8, Issue:14, 2007
Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies.FEBS letters, , Oct-02, Volume: 581, Issue:24, 2007
Transgenic animal models of neurodegenerative diseases and their application to treatment development.Advanced drug delivery reviews, , Sep-30, Volume: 59, Issue:11, 2007
[Study on pathophysiology of autophagy].Seikagaku. The Journal of Japanese Biochemical Society, , Volume: 79, Issue:8, 2007
Functional protein kinase arrays reveal inhibition of p-21-activated kinase 4 by alpha-synuclein oligomers.Journal of neurochemistry, , Volume: 103, Issue:6, 2007
Is alpha-synuclein pathology a target for treatment of neurodegenerative disorders?Current Alzheimer research, , Volume: 4, Issue:4, 2007
Lipid rafts, protein scaffolds, and neurologic disease.Neurology, , Oct-16, Volume: 69, Issue:16, 2007
Protein aggregation mechanisms in synucleinopathies: commonalities and differences.Journal of neuropathology and experimental neurology, , Volume: 66, Issue:11, 2007
Phosphorylated Smad 2/3 colocalizes with phospho-tau inclusions in Pick disease, progressive supranuclear palsy, and corticobasal degeneration but not with alpha-synuclein inclusions in multiple system atrophy or dementia with Lewy bodies.Journal of neuropathology and experimental neurology, , Volume: 66, Issue:11, 2007
Brain tissue microarrays in neurodegenerative diseases: validation of methodology and immunohistochemical study of growth-associated protein-43 and calretinin.Pathology international, , Volume: 57, Issue:12, 2007
Is alpha-synuclein pathology a target for treatment of neurodegenerative disorders?Current Alzheimer research, , Volume: 4, Issue:5, 2007
Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice.Neurobiology of aging, , Volume: 28, Issue:9, 2007
Identification of G-protein coupled receptor kinase 2 in paired helical filaments and neurofibrillary tangles.Journal of neuropathology and experimental neurology, , Volume: 65, Issue:12, 2006
REM sleep behavior disorder: a possible early marker for synucleinopathies.Neurology, , Dec-12, Volume: 67, Issue:11, 2006
Rescuing defective vesicular trafficking protects against alpha-synuclein toxicity in cellular and animal models of Parkinson's disease.ACS chemical biology, , Aug-22, Volume: 1, Issue:7, 2006
Tau-predominant-associated pathology in a sporadic late-onset Hallervorden-Spatz syndrome.Movement disorders : official journal of the Movement Disorder Society, , Volume: 21, Issue:1, 2006
Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein.The Journal of biological chemistry, , Apr-14, Volume: 281, Issue:15, 2006
Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies.The American journal of pathology, , Volume: 168, Issue:3, 2006
[Nosology of dementias: the neuropathologist's point of view].Revue neurologique, , Volume: 162, Issue:10, 2006
Human brain tissue microarrays as a platform to investigate diseases of the nervous system.Brain research, , May-17, Volume: 1089, Issue:1, 2006
Hero versus antihero: the multiple roles of alpha-synuclein in neurodegeneration.Experimental neurology, , Volume: 199, Issue:2, 2006
Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies.Journal of neuropathology and experimental neurology, , Volume: 65, Issue:4, 2006
Cytoskeleton/endoplasmic reticulum collapse induced by prostaglandin J2 parallels centrosomal deposition of ubiquitinated protein aggregates.The Journal of biological chemistry, , Aug-11, Volume: 281, Issue:32, 2006
Emerging evidence for the neuroprotective role of alpha-synuclein.Experimental neurology, , Volume: 200, Issue:1, 2006
Archaeal proteasomes effectively degrade aggregation-prone proteins and reduce cellular toxicities in mammalian cells.The Journal of biological chemistry, , Aug-18, Volume: 281, Issue:33, 2006
The genetics of neurodegenerative diseases.Journal of neurochemistry, , Volume: 97, Issue:6, 2006
[Neurodegenerative conformational disease and its molecular bases].Sheng li ke xue jin zhan [Progress in physiology], , Volume: 37, Issue:2, 2006
New directions for neurodegenerative disease therapy: using chemical compounds to boost the formation of mutant protein inclusions.Cell cycle (Georgetown, Tex.), , Volume: 5, Issue:14, 2006
Glial degeneration and reactive gliosis in alpha-synucleinopathies: the emerging concept of primary gliodegeneration.Acta neuropathologica, , Volume: 112, Issue:5, 2006
Mechanisms and models of alpha-synuclein-related neurodegeneration.Current neurology and neuroscience reports, , Volume: 6, Issue:5, 2006
p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies.The Journal of biological chemistry, , Feb-18, Volume: 280, Issue:7, 2005
Annular alpha-synuclein oligomers are potentially toxic agents in alpha-synucleinopathy. Hypothesis.Neurotoxicity research, , Volume: 7, Issue:1-2, 2005
The role of alpha-synuclein in neurodegenerative diseases.Pharmacology & therapeutics, , Volume: 105, Issue:3, 2005
Alpha-synuclein aggregation and its relation to neurodegenerative diseases.Annals of neurology, , Volume: 57, Issue:4, 2005
Pathogenic effects of alpha-synuclein aggregation.Brain research. Molecular brain research, , Mar-24, Volume: 134, Issue:1, 2005
Prediction of "aggregation-prone" and "aggregation-susceptible" regions in proteins associated with neurodegenerative diseases.Journal of molecular biology, , Jul-08, Volume: 350, Issue:2, 2005
Neuronal intranuclear inclusion disease without polyglutamine inclusions in a child.Journal of neuropathology and experimental neurology, , Volume: 64, Issue:6, 2005
Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology.Acta neuropathologica, , Volume: 110, Issue:2, 2005
The role of alpha-synuclein and tau in neurodegenerative movement disorders.Current opinion in neurology, , Volume: 18, Issue:4, 2005
Agrin binds alpha-synuclein and modulates alpha-synuclein fibrillation.Glycobiology, , Volume: 15, Issue:12, 2005
Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and drug-induced rotational asymmetry in hemi-parkinsonian rats.Journal of neurochemistry, , Volume: 95, Issue:4, 2005
Prediction of "hot spots" of aggregation in disease-linked polypeptides.BMC structural biology, , Sep-30, Volume: 5, 2005
The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy.British journal of pharmacology, , Volume: 146, Issue:8, 2005
Metal ions and oxidative protein modification in neurological disease.Annali dell'Istituto superiore di sanita, , Volume: 41, Issue:2, 2005
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Studies of the aggregation of an amyloidogenic alpha-synuclein peptide fragment.Biochemical Society transactions, , Volume: 33, Issue:Pt 5, 2005
Proteasomal inhibition by alpha-synuclein filaments and oligomers.The Journal of biological chemistry, , Mar-26, Volume: 279, Issue:13, 2004
Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-25, Volume: 24, Issue:8, 2004
More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases.Trends in neurosciences, , Volume: 27, Issue:3, 2004
Alpha-synuclein: normal function and role in neurodegenerative diseases.Current topics in developmental biology, , Volume: 60, 2004
Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons.The Journal of cell biology, , May-10, Volume: 165, Issue:3, 2004
Following the leader: fibrillization of alpha-synuclein and tau.Experimental neurology, , Volume: 187, Issue:2, 2004
Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling.Proceedings of the National Academy of Sciences of the United States of America, , Jun-01, Volume: 101, Issue:22, 2004
Does cellular iron dysregulation play a causative role in Parkinson's disease?Ageing research reviews, , Volume: 3, Issue:3, 2004
Neurodegenerative diseases caused by protein aggregation: a phenomenon at the borderline between molecular evolution and ageing.Pharmacological research, , Volume: 50, Issue:4, 2004
Beta-Synuclein-derived peptides with neuroprotective activity: an alternative treatment of neurodegenerative disorders?Journal of molecular neuroscience : MN, , Volume: 24, Issue:1, 2004
Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro.Biochemical and biophysical research communications, , Aug-27, Volume: 321, Issue:3, 2004
[Analysis of alpha-synuclein and its significance].Nihon rinsho. Japanese journal of clinical medicine, , Volume: 62, Issue:9, 2004
Alpha-synuclein and transgenic mouse models.Neurobiology of disease, , Volume: 17, Issue:2, 2004
Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies.Neurobiology of disease, , Volume: 17, Issue:2, 2004
Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Oct-20, Volume: 24, Issue:42, 2004
Lewy bodies in the amygdala: increase of alpha-synuclein aggregates in neurodegenerative diseases with tau-based inclusions.Archives of neurology, , Volume: 61, Issue:12, 2004
Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.Experimental neurology, , Volume: 179, Issue:1, 2003
Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila.Neuroscience letters, , Jan-23, Volume: 336, Issue:3, 2003
Nucleus-specific alteration of raphe neurons in human neurodegenerative disorders.Neuroreport, , Jan-20, Volume: 14, Issue:1, 2003
Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , Mar-04, Volume: 100, Issue:5, 2003
Alpha-synuclein pathology affecting Bergmann glia of the cerebellum in patients with alpha-synucleinopathies.Acta neuropathologica, , Volume: 105, Issue:4, 2003
Ubiquitinated inclusions and neuronal cell death.Histology and histopathology, , Volume: 18, Issue:2, 2003
Association of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathies.The Journal of biological chemistry, , Jun-27, Volume: 278, Issue:26, 2003
Initiation and synergistic fibrillization of tau and alpha-synuclein.Science (New York, N.Y.), , Apr-25, Volume: 300, Issue:5619, 2003
Alpha-synuclein overexpression protects against paraquat-induced neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Apr-15, Volume: 23, Issue:8, 2003
Alpha-synuclein aggregation and neurodegenerative diseases.Journal of Alzheimer's disease : JAD, , Volume: 5, Issue:2, 2003
Familial idiopathic brain calcification--a new and familial alpha-synucleinopathy?European neurology, , Volume: 49, Issue:4, 2003
Alpha-synuclein: its biological function and role in neurodegenerative diseases.Journal of molecular neuroscience : MN, , Volume: 20, Issue:2, 2003
Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein.Journal of neurochemistry, , Volume: 86, Issue:1, 2003
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Oxidative modifications of alpha-synuclein.Annals of the New York Academy of Sciences, , Volume: 991, 2003
Cell cycle aberrations by alpha-synuclein over-expression and cyclin B immunoreactivity in Lewy bodies.Neurobiology of aging, , Volume: 24, Issue:5, 2003
Toward a molecular neuropsychiatry of neurodegenerative diseases.Annals of neurology, , Volume: 54, Issue:2, 2003
Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of alpha-synuclein.Brain pathology (Zurich, Switzerland), , Volume: 13, Issue:3, 2003
A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114.Journal of neurochemistry, , Volume: 86, Issue:6, 2003
A protein-chameleon: conformational plasticity of alpha-synuclein, a disordered protein involved in neurodegenerative disorders.Journal of biomolecular structure & dynamics, , Volume: 21, Issue:2, 2003
Alpha-synuclein: between synaptic function and dysfunction.Histology and histopathology, , Volume: 18, Issue:4, 2003
Neuropathological spectrum of synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 18 Suppl 6, 2003
Clinical overview of the synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 18 Suppl 6, 2003
Tau pathology in the olfactory bulb correlates with Braak stage, Lewy body pathology and apolipoprotein epsilon4.Neuropathology and applied neurobiology, , Volume: 29, Issue:5, 2003
Altered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathies.The Journal of biological chemistry, , Dec-12, Volume: 278, Issue:50, 2003
Alpha-synuclein oligomerization: a role for lipids?Trends in neurosciences, , Volume: 26, Issue:10, 2003
Challenges and complexities of alpha-synuclein toxicity: new postulates in unfolding the mystery associated with Parkinson's disease.Archives of biochemistry and biophysics, , Oct-15, Volume: 418, Issue:2, 2003
Interactions of amyloidogenic proteins.Neuromolecular medicine, , Volume: 4, Issue:1-2, 2003
Mutations in the lipid-binding domain of alpha-synuclein confer overlapping, yet distinct, functional properties in the regulation of dopamine transporter activity.Molecular and cellular neurosciences, , Volume: 24, Issue:1, 2003
Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation.Molecular and cellular neurosciences, , Volume: 24, Issue:2, 2003
[Neuropathology of tauopathies and synucleinopathies, and neuroanatomy of sleep disorders: meeting the challenge].Revue neurologique, , Volume: 159, Issue:11 Suppl, 2003
Evidence that alpha-synuclein functions as a negative regulator of Ca(++)-dependent alpha-granule release from human platelets.Blood, , Oct-01, Volume: 100, Issue:7, 2002
Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions.The Journal of biological chemistry, , Dec-13, Volume: 277, Issue:50, 2002
The neuropathogenic contributions of lysosomal dysfunction.Journal of neurochemistry, , Volume: 83, Issue:3, 2002
Mice expressing the alpha(1B)-adrenergic receptor induces a synucleinopathy with excessive tyrosine nitration but decreased phosphorylation.Journal of neurochemistry, , Volume: 83, Issue:3, 2002
Parkinson's disease and related synucleinopathies are a new class of nervous system amyloidoses.Neurotoxicology, , Volume: 23, Issue:4-5, 2002
Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies.The Journal of clinical investigation, , Volume: 110, Issue:10, 2002
Familial Lewy body diseases.Journal of geriatric psychiatry and neurology, ,Winter, Volume: 15, Issue:4, 2002
Tubulin seeds alpha-synuclein fibril formation.The Journal of biological chemistry, , Jan-18, Volume: 277, Issue:3, 2002
The synucleins.Genome biology, , Volume: 3, Issue:1, 2002
alpha-Synuclein is phosphorylated in synucleinopathy lesions.Nature cell biology, , Volume: 4, Issue:2, 2002
Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease.Science (New York, N.Y.), , Feb-01, Volume: 295, Issue:5556, 2002
Biochemical characterization of the core structure of alpha-synuclein filaments.The Journal of biological chemistry, , May-24, Volume: 277, Issue:21, 2002
Immunocytochemical localization of synphilin-1, an alpha-synuclein-associated protein, in neurodegenerative disorders.Acta neuropathologica, , Volume: 103, Issue:3, 2002
Ultrastructure of alpha-synuclein-positive aggregations in U373 astrocytoma and rat primary glial cells.Neuroscience letters, , Apr-19, Volume: 323, Issue:1, 2002
Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Apr-01, Volume: 22, Issue:7, 2002
The cell biology of alpha-synuclein: a sticky problem?Neuromolecular medicine, , Volume: 1, Issue:2, 2002
Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.Neuron, , May-16, Volume: 34, Issue:4, 2002
The effects of aggregation-inducing motifs on amyloid formation of model proteins related to neurodegenerative diseases.Biochemistry, , Aug-13, Volume: 41, Issue:32, 2002
The prion protein in human neurodegenerative disorders.Neuroscience letters, , Sep-06, Volume: 329, Issue:3, 2002
Self-oligomerization and protein aggregation of alpha-synuclein in the presence of Coomassie Brilliant Blue.European journal of biochemistry, , Volume: 268, Issue:2, 2001
Synucleinopathies: clinical and pathological implications.Archives of neurology, , Volume: 58, Issue:2, 2001
From genetics to pathology: tau and alpha-synuclein assemblies in neurodegenerative diseases.Philosophical transactions of the Royal Society of London. Series B, Biological sciences, , Feb-28, Volume: 356, Issue:1406, 2001
Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins.Mechanisms of ageing and development, , Jul-15, Volume: 122, Issue:9, 2001
The significance of tau and alpha-synuclein inclusions in neurodegenerative diseases.Current opinion in genetics & development, , Volume: 11, Issue:3, 2001
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Alpha-synuclein and neurodegenerative diseases.Nature reviews. Neuroscience, , Volume: 2, Issue:7, 2001
Expression of alpha-synuclein in a human glioma cell line and its up-regulation by interleukin-1beta.Neuroreport, , Jul-03, Volume: 12, Issue:9, 2001
Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies.Neuroreport, , Jul-20, Volume: 12, Issue:10, 2001
Multiple ligand interaction of alpha-synuclein produced various forms of protein aggregates in the presence of Abeta25-35, copper, and eosin.Brain research, , Jul-20, Volume: 908, Issue:1, 2001
Genomic organization, chromosome location, and expression analysis of mouse beta-synuclein, a candidate for involvement in neurodegeneration.Cytogenetics and cell genetics, , Volume: 93, Issue:1-2, 2001
Membrane binding and self-association of alpha-synucleins.Biochemistry, , Aug-21, Volume: 40, Issue:33, 2001
Glial cell death induced by overexpression of alpha-synuclein.Journal of neuroscience research, , Sep-01, Volume: 65, Issue:5, 2001
Induction of alpha-synuclein aggregation by intracellular nitrative insult.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Oct-15, Volume: 21, Issue:20, 2001
Expression of beta-synuclein in normal human astrocytes.Neuroreport, , Sep-17, Volume: 12, Issue:13, 2001
beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor.Neuron, , Oct-25, Volume: 32, Issue:2, 2001
Production of reactive oxygen species from aggregating proteins implicated in Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases.Current topics in medicinal chemistry, , Volume: 1, Issue:6, 2001
C-terminal alpha-synuclein immunoreactivity in structures other than Lewy bodies in neurodegenerative disorders.Acta neuropathologica, , Volume: 99, Issue:3, 2000
Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders.Science (New York, N.Y.), , Feb-18, Volume: 287, Issue:5456, 2000
Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies.The Journal of biological chemistry, , Jun-16, Volume: 275, Issue:24, 2000
Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience, , May-01, Volume: 20, Issue:9, 2000
Neuropathology of synuclein aggregates.Journal of neuroscience research, , Jul-15, Volume: 61, Issue:2, 2000
Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology.The American journal of pathology, , Volume: 157, Issue:2, 2000
Neuropathology in mice expressing human alpha-synuclein.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Aug-15, Volume: 20, Issue:16, 2000
Review: formation and properties of amyloid-like fibrils derived from alpha-synuclein and related proteins.Journal of structural biology, , Volume: 130, Issue:2-3, 2000
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions.Science (New York, N.Y.), , Nov-03, Volume: 290, Issue:5493, 2000
Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies.The American journal of pathology, , Volume: 157, Issue:5, 2000
Microtubule-associated protein tau, heparan sulphate and alpha-synuclein in several neurodegenerative diseases with dementia.Acta neuropathologica, , Volume: 97, Issue:6, 1999
Filamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and alpha-synucleinopathies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences, , Jun-29, Volume: 354, Issue:1386, 1999
Synucleins in synaptic plasticity and neurodegenerative disorders.Journal of neuroscience research, , Oct-01, Volume: 58, Issue:1, 1999
The expression of alpha-, beta-, and gamma-synucleins in olfactory mucosa from patients with and without neurodegenerative diseases.Experimental neurology, , Volume: 160, Issue:2, 1999
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The synuclein family.Genome research, , Volume: 8, Issue:9, 1998
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Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments.FEBS letters, , Nov-27, Volume: 440, Issue:1-2, 1998
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Alpha-synuclein stimulation of astrocytes: Potential role for neuroinflammation and neuroprotection.Oxidative medicine and cellular longevity, , Volume: 3, Issue:4
A review on the cause-effect relationship between oxidative stress and toxic proteins in the pathogenesis of neurodegenerative diseases.Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, , Volume: 118, Issue:1
Dual pathology of corticobasal degeneration and Parkinson's disease in a patient with clinical features of progressive supranuclear palsy.Neurology India, , Volume: 59, Issue:6
Manganese and related neurotoxic pathways: A potential therapeutic target in neurodegenerative diseases.Neurotoxicology and teratology, , Volume: 94
No Detectable Effect on Visual Responses Using Functional MRI in a Rodent Model of α-Synuclein Expression.eNeuro, , Volume: 8, Issue:3
Alpha-synuclein Levels in Cerebrospinal Fluid in Patients With Lewy Bodies Dementia and Other Neurodegenerative Disorders.Alzheimer disease and associated disorders, , Volume: 35, Issue:2
Editorial: Proteomic alterations by mutations involved in Parkinson's disease and related disorders.Current protein & peptide science, , Volume: 18, Issue:7
Response to the Letter to the Editor by Tomoyuki Kawada: "Alpha-Synuclein Levels in Cerebrospinal Fluid in Patients With Lewy Bodies Dementia and Other Neurodegenerative Disorders".Alzheimer disease and associated disorders, , Volume: 35, Issue:2
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Alpha-synuclein is strategically positioned for afferent modulation of midbrain dopamine neurons and is essential for cocaine preference.Communications biology, , Volume: 2, 2019
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An α-synuclein gene (SNCA) polymorphism moderates the association of PTSD symptomatology with hazardous alcohol use, but not with aggression-related measures.Journal of anxiety disorders, , Volume: 30, 2015
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Misfolded α-Synuclein Assessment in the Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorder.Neurology, , 05-02, Volume: 100, Issue:18, 2023
Oligomeric Alpha-Synuclein and STX-1A from Neural-Derived Extracellular Vesicles (NDEVs) as Possible Biomarkers of REM Sleep Behavior Disorder in Parkinson's Disease: A Preliminary Cohort Study.International journal of molecular sciences, , May-16, Volume: 24, Issue:10, 2023
Pharmacological interventions targeting α-synuclein aggregation triggered REM sleep behavior disorder and early development of Parkinson's disease.Pharmacology & therapeutics, , Volume: 249, 2023
Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional study.The Lancet. Neurology, , Volume: 22, Issue:5, 2023
Accurate Detection of α-Synuclein Seeds in Cerebrospinal Fluid from Isolated Rapid Eye Movement Sleep Behavior Disorder and Patients with Parkinson's Disease in the DeNovo Parkinson (DeNoPa) Cohort.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:4, 2023
Dermal Real-Time Quaking-Induced Conversion Is a Sensitive Marker to Confirm Isolated Rapid Eye Movement Sleep Behavior Disorder as an Early α-Synucleinopathy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:6, 2023
The brain-first vs. body-first model of Parkinson's disease with comparison to alternative models.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 130, Issue:6, 2023
α-Synuclein Induced the Occurrence of RBD via Interaction with OX1R and Modulated Its Degradation.Neuromolecular medicine, , Volume: 25, Issue:2, 2023
Relationship between Substantia Nigra Neuromelanin Imaging and Dual Alpha-Synuclein Labeling of Labial Minor in Salivary Glands in Isolated Rapid Eye Movement Sleep Behavior Disorder and Parkinson's Disease.Genes, , Sep-24, Volume: 13, Issue:10, 2022
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Striatal-Inoculation of α-Synuclein Preformed Fibrils Aggravated the Phenotypes of REM Sleep without Atonia in A53T BAC-SNCA Transgenic Mice.International journal of molecular sciences, , Nov-02, Volume: 23, Issue:21, 2022
Clinical and imaging evidence of brain-first and body-first Parkinson's disease.Neurobiology of disease, , Volume: 164, 2022
Gray Matter Volume Loss in Proposed Brain-First and Body-First Parkinson's Disease Subtypes.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:10, 2022
Associations of sleep disorders with cerebrospinal fluid α-synuclein in prodromal and early Parkinson's disease.Journal of neurology, , Volume: 269, Issue:5, 2022
Recent advances in establishing fluid biomarkers for the diagnosis and differentiation of alpha-synucleinopathies - a mini review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 32, Issue:4, 2022
Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies.Brain : a journal of neurology, , 04-18, Volume: 145, Issue:2, 2022
Brain atrophy in prodromal synucleinopathy is shaped by structural connectivity and gene expression.Brain : a journal of neurology, , 09-14, Volume: 145, Issue:9, 2022
Different patterns of exosomal α-synuclein between Parkinson's disease and probable rapid eye movement sleep behavior disorder.European journal of neurology, , Volume: 29, Issue:12, 2022
Idiopathic rapid eye movement sleep behavior disorder in Japan: An observational study.Parkinsonism & related disorders, , Volume: 103, 2022
Association between probable REM sleep behavior disorder and increased dermal alpha-synuclein deposition in Parkinson's disease.Parkinsonism & related disorders, , Volume: 99, 2022
Neuroinflammation and Immune Changes in Prodromal Parkinson's Disease and Other Synucleinopathies.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
Hypomethylation of SNCA in Idiopathic REM Sleep Behavior Disorder Associated With Phenoconversion.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:4, 2021
Consistent skin α-synuclein positivity in REM sleep behavior disorder - A two center two-to-four-year follow-up study.Parkinsonism & related disorders, , Volume: 86, 2021
Asymmetric Dopaminergic Dysfunction in Brain-First versus Body-First Parkinson's Disease Subtypes.Journal of Parkinson's disease, , Volume: 11, Issue:4, 2021
Brainstem Quadruple Aberrant Hyperphosphorylated Tau, Beta-Amyloid, Alpha-Synuclein and TDP-43 Pathology, Stress and Sleep Behavior Disorders.International journal of environmental research and public health, , 06-22, Volume: 18, Issue:13, 2021
REM sleep behavior disorder and other sleep abnormalities in p. A53T SNCA mutation carriers.Sleep, , 05-14, Volume: 44, Issue:5, 2021
Alpha-synuclein seeds in olfactory mucosa of patients with isolated REM sleep behaviour disorder.Brain : a journal of neurology, , 05-07, Volume: 144, Issue:4, 2021
Increased Accumulation of α-Synuclein in Inflamed Appendices of Parkinson's Disease Patients.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:8, 2021
Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder.The Lancet. Neurology, , Volume: 20, Issue:8, 2021
Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study.The Lancet. Neurology, , Volume: 20, Issue:3, 2021
Immunohistochemical Detection of Synuclein Pathology in Skin in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:4, 2021
Cutaneous α-synuclein is correlated with autonomic impairment in isolated rapid eye movement sleep behavior disorder.Sleep, , 12-10, Volume: 44, Issue:12, 2021
The role of tissue biopsy as a biomarker in REM sleep behavior disorder.Sleep medicine reviews, , Volume: 51, 2020
Fine-Mapping of SNCA in Rapid Eye Movement Sleep Behavior Disorder and Overt Synucleinopathies.Annals of neurology, , Volume: 87, Issue:4, 2020
α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson's disease model.Brain : a journal of neurology, , 01-01, Volume: 143, Issue:1, 2020
SNCA Hypomethylation in Rapid Eye Movement Sleep Behavior Disorder Is a Potential Biomarker for Parkinson's Disease.Journal of Parkinson's disease, , Volume: 10, Issue:3, 2020
[REM Sleep Behavior Disorder and α-synucleinopathy].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:2, 2020
Propagated α-synucleinopathy recapitulates REM sleep behaviour disorder followed by parkinsonian phenotypes in mice.Brain : a journal of neurology, , 12-05, Volume: 143, Issue:11, 2020
Impaired metabolic brain networks associated with neurotransmission systems in the α-synuclein spectrum.Parkinsonism & related disorders, , Volume: 81, 2020
Abnormal α-synuclein deposits in skin nerves: intra- and inter-laboratory reproducibility.European journal of neurology, , Volume: 26, Issue:10, 2019
Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients.Annals of clinical and translational neurology, , Volume: 6, Issue:9, 2019
Precision Medicine in Rapid Eye Movement Sleep Behavior Disorder.Sleep medicine clinics, , Volume: 14, Issue:3, 2019
Longitudinal analyses of cerebrospinal fluid α-Synuclein in prodromal and early Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:9, 2019
CSF Biomarkers for Early Diagnosis of Synucleinopathies: Focus on Idiopathic RBD.Current neurology and neuroscience reports, , 01-14, Volume: 19, Issue:2, 2019
Simultaneous tonic and phasic REM sleep without atonia best predicts early phenoconversion to neurodegenerative disease in idiopathic REM sleep behavior disorder.Sleep, , 09-06, Volume: 42, Issue:9, 2019
[A case of severe obstructive sleep apnea mimicking REM sleep behavior disorder].Rinsho shinkeigaku = Clinical neurology, , Apr-25, Volume: 59, Issue:4, 2019
[Differential diagnosis of RBD symptomatology (idiopathic RBD or RBD mimics)].Rinsho shinkeigaku = Clinical neurology, , Apr-25, Volume: 59, Issue:4, 2019
Risk variants of the α-synuclein locus and REM sleep behavior disorder in Parkinson's disease: a genetic association study.BMC neurology, , Feb-21, Volume: 18, Issue:1, 2018
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The "when" and "where" of α-synucleinopathies: Insights from REM sleep behavior disorder.Neurology, , 09-04, Volume: 91, Issue:10, 2018
REM behavior disorder predicts motor progression and cognitive decline in Parkinson disease.Neurology, , 09-04, Volume: 91, Issue:10, 2018
Skin nerve phosphorylated α-synuclein deposits in idiopathic REM sleep behavior disorder.Neurology, , May-30, Volume: 88, Issue:22, 2017
SNCA 3'UTR genetic variants in patients with Parkinson's disease and REM sleep behavior disorder.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 38, Issue:7, 2017
Dermal phospho-alpha-synuclein deposits confirm REM sleep behaviour disorder as prodromal Parkinson's disease.Acta neuropathologica, , Volume: 133, Issue:4, 2017
Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.Disease models & mechanisms, , 05-01, Volume: 10, Issue:5, 2017
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REM sleep behavior disorder is related to enteric neuropathology in Parkinson disease.Neurology, , Oct-10, Volume: 89, Issue:15, 2017
Assessment of α-synuclein in submandibular glands of patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study.The Lancet. Neurology, , Volume: 15, Issue:7, 2016
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Enteric nervous system α-synuclein immunoreactivity in idiopathic REM sleep behavior disorder.Neurology, , Nov-17, Volume: 85, Issue:20, 2015
[REM sleep behavior disorder as a prodromal stage of α-synucleinopathies: symptoms, epidemiology, pathophysiology, diagnosis and therapy].Der Nervenarzt, , Volume: 85, Issue:1, 2014
Dysfunction of the locus coeruleus-norepinephrine system and related circuitry in Parkinson's disease-related dementia.Journal of neurology, neurosurgery, and psychiatry, , Volume: 84, Issue:7, 2013
MRI and pathology of REM sleep behavior disorder in dementia with Lewy bodies.Neurology, , Nov-05, Volume: 81, Issue:19, 2013
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Neuropathological analysis of brainstem cholinergic and catecholaminergic nuclei in relation to rapid eye movement (REM) sleep behaviour disorder.Neuropathology and applied neurobiology, , Volume: 38, Issue:2, 2012
α-Synuclein and anti-α-synuclein antibodies in Parkinson's disease, atypical Parkinson syndromes, REM sleep behavior disorder, and healthy controls.PloS one, , Volume: 7, Issue:12, 2012
Hallucinations and REM sleep behaviour disorder in Parkinson's disease: dream imagery intrusions and other hypotheses.Consciousness and cognition, , Volume: 20, Issue:4, 2011
Regional cerebral blood flow changes in patients with idiopathic REM sleep behavior disorder.European journal of neurology, , Volume: 18, Issue:5, 2011
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[Pathophysiological process underlying Parkinson's disease: motor & non-motor symptoms].Rinsho shinkeigaku = Clinical neurology, , Volume: 49, Issue:11, 2009
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[Sleep behavior disorder (RBD) in synucleionopaties].Glas. Srpska akademija nauka i umetnosti. Odeljenje medicinskih nauka, , Issue:50, 2009
Expanding the clinical phenotype of SNCA duplication carriers.Movement disorders : official journal of the Movement Disorder Society, , Sep-15, Volume: 24, Issue:12, 2009
Autonomic dysfunction in RBD--what can it teach us about disease progression?Sleep medicine, , Volume: 9, Issue:5, 2008
Validation of the neuropathologic criteria of the third consortium for dementia with Lewy bodies for prospectively diagnosed cases.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:7, 2008
Classical Parkinson disease versus Parkinson complex--reflections against staging and in favour of heterogeneity.European journal of neurology, , Volume: 14, Issue:7, 2007
A 75-year-old man with cognitive impairment and gait changes.Neurology, , Sep-11, Volume: 69, Issue:11, 2007
REM sleep behavior disorder: a possible early marker for synucleinopathies.Neurology, , Dec-12, Volume: 67, Issue:11, 2006
REM sleep behavior disorder: a possible early marker for synucleinopathies.Neurology, , Mar-28, Volume: 66, Issue:6, 2006
Abnormal sleep architecture is an early feature in the E46K familial synucleinopathy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20, Issue:10, 2005
Idiopathic REM sleep behavior disorder: toward a better nosologic definition.Neurology, , Mar-08, Volume: 64, Issue:5, 2005
Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium.Neurology, , Dec-27, Volume: 65, Issue:12, 2005
Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism.Neurology, , Jul-08, Volume: 61, Issue:1, 2003
Ischemic stroke causes Parkinson's disease-like pathology and symptoms in transgenic mice overexpressing alpha-synuclein.Acta neuropathologica communications, , 02-24, Volume: 10, Issue:1, 2022
Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 41, Issue:5, 2021
Impact of Age and Sex on α-Syn (α-Synuclein) Knockdown-Mediated Poststroke Recovery.Stroke, , Volume: 51, Issue:10, 2020
Neuroprotective Effect of Dichloromethane Extraction From Piper nigrum L. and Piper longum L. on Permanent Focal Cerebral Ischemia Injury in Rats.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, , Volume: 28, Issue:3, 2019
The roles of HSP40/DNAJ protein family in neurodegenerative diseases.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, , Nov-25, Volume: 51, Issue:5, 2022
Analysis of circulating metabolites to differentiate Parkinson's disease and essential tremor.Neuroscience letters, , 01-19, Volume: 769, 2022
Characterizing Lewy Pathology in 231 Essential Tremor Brains From the Essential Tremor Centralized Brain Repository.Journal of neuropathology and experimental neurology, , 09-19, Volume: 81, Issue:10, 2022
Can Plasma α-Synuclein Help Us to Differentiate Parkinson's Disease from Essential Tremor?Tremor and other hyperkinetic movements (New York, N.Y.), , 05-28, Volume: 11, 2021
Central Nervous System-Derived Exosomal Alpha-Synuclein in Serum May Be a Biomarker in Parkinson's Disease.Neuroscience, , 08-10, Volume: 413, 2019
Matching asymmetry of tremor with asymmetry of postmortem cerebellar hemispheric changes in essential tremor.Cerebellum (London, England), , Volume: 13, Issue:4, 2014
Genetic variants of α-synuclein are not associated with essential tremor.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:14, 2011
A family with Parkinsonism, essential tremor, restless legs syndrome, and depression.Neurology, , May-10, Volume: 76, Issue:19, 2011
Rest tremor in advanced essential tremor: a post-mortem study of nine cases.Journal of neurology, neurosurgery, and psychiatry, , Volume: 82, Issue:3, 2011
Essential tremor is not associated with alpha-synuclein gene haplotypes.Movement disorders : official journal of the Movement Disorder Society, , Volume: 18, Issue:7, 2003
Genetics of parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Volume: 17, Issue:4, 2002
Analysis of the coding and the 5' flanking regions of the alpha-synuclein gene in patients with Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 16, Issue:6, 2001
Propofol Attenuates α-Synuclein Aggregation and Neuronal Damage in a Mouse Model of Ischemic Stroke.Neuroscience bulletin, , Volume: 36, Issue:3, 2020
Poststroke Induction of α-Synuclein Mediates Ischemic Brain Damage.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 06-29, Volume: 36, Issue:26, 2016
Frontal lobe white matter hyperintensities and neurofibrillary pathology in the oldest old.Neurology, , Dec-07, Volume: 75, Issue:23, 2010
Tau and GSK-3β are Critical Contributors to α-Synuclein-Mediated Post-Stroke Brain Damage.Neuromolecular medicine, , Volume: 25, Issue:1, 2023
Joint efficacy of the three biomarkers SNCA, GYPB and HBG1 for atrial fibrillation and stroke: Analysis via the support vector machine neural network.Journal of cellular and molecular medicine, , Volume: 26, Issue:7, 2022
Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 41, Issue:5, 2021
How gut microbes could drive brain disorders.Nature, , Volume: 590, Issue:7844, 2021
Impact of Age and Sex on α-Syn (α-Synuclein) Knockdown-Mediated Poststroke Recovery.Stroke, , Volume: 51, Issue:10, 2020
Propofol Attenuates α-Synuclein Aggregation and Neuronal Damage in a Mouse Model of Ischemic Stroke.Neuroscience bulletin, , Volume: 36, Issue:3, 2020
Visual discrimination impairment after experimental stroke is associated with disturbances in the polarization of the astrocytic aquaporin-4 and increased accumulation of neurotoxic proteins.Experimental neurology, , Volume: 318, 2019
The microRNA miR-7a-5p ameliorates ischemic brain damage by repressing α-synuclein.Science signaling, , 12-11, Volume: 11, Issue:560, 2018
A comparative study of the amount of α-synuclein in ischemic stroke and Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 37, Issue:5, 2016
Poststroke Induction of α-Synuclein Mediates Ischemic Brain Damage.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 06-29, Volume: 36, Issue:26, 2016
Na(+)-K (+)-2Cl (-) cotransport inhibitor attenuates cerebral edema following experimental stroke via the perivascular pool of aquaporin-4.Neurocritical care, , Volume: 13, Issue:1, 2010
Seed amplification assay results illustrate discrepancy in Parkinson's disease clinical diagnostic accuracy and error rates.Journal of neurology, , Volume: 270, Issue:12, 2023
Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions.Proceedings of the National Academy of Sciences of the United States of America, , 03-28, Volume: 120, Issue:13, 2023
Interlinked role of ASN, TDP-43 and Miro1 with parkinopathy: Focus on targeted approach against neuropathy in parkinsonism.Ageing research reviews, , Volume: 83, 2023
Oligomeric α-synuclein and tau aggregates in NDEVs differentiate Parkinson's disease from atypical parkinsonisms.Neurobiology of disease, , Volume: 176, 2023
Role of Oligodendrocyte Lineage Cells in Multiple System Atrophy.Cells, , 02-25, Volume: 12, Issue:5, 2023
Neuroprotective effects of isatin and afobazole in rats with rotenone-induced Parkinsonism are accompanied by increased brain levels of Triton X-100 soluble alpha-synuclein.Biomeditsinskaia khimiia, , Volume: 69, Issue:5, 2023
Hippocampal synaptic failure is an early event in experimental parkinsonism with subtle cognitive deficit.Brain : a journal of neurology, , Dec-01, Volume: 146, Issue:12, 2023
Evaluation of α-synuclein in CNS-originating extracellular vesicles for Parkinsonian disorders: A systematic review and meta-analysis.CNS neuroscience & therapeutics, , Volume: 29, Issue:12, 2023
The unexpected finding of CNS autoantibodies in GBA1 mutation carriers with atypical parkinsonism.Journal of neuropathology and experimental neurology, , 08-21, Volume: 82, Issue:9, 2023
Novel FABP3 ligand, HY-11-9, ameliorates neuropathological deficits in MPTP-induced Parkinsonism in mice.Journal of pharmacological sciences, , Volume: 152, Issue:1, 2023
Impaired aldehyde detoxification exacerbates motor deficits in an alpha-synuclein mouse model of Parkinson's disease.Brain and behavior, , Volume: 13, Issue:9, 2023
Blood-Based α-Synuclein Seeding-A New Era for Identifying Parkinsonian Syndromes.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:8, 2023
Translational molecular imaging and drug development in Parkinson's disease.Molecular neurodegeneration, , 02-10, Volume: 18, Issue:1, 2023
Combined CSF α-SYN RT-QuIC, CSF NFL and midbrain-pons planimetry in degenerative parkinsonisms: From bedside to bench, and back again.Parkinsonism & related disorders, , Volume: 99, 2022
Paraquat exposure induces Parkinsonism by altering lipid profile and evoking neuroinflammation in the midbrain.Environment international, , Volume: 169, 2022
Non-Reproducibility of Oral Rotenone as a Model for Parkinson's Disease in Mice.International journal of molecular sciences, , Oct-21, Volume: 23, Issue:20, 2022
Glutathione Depletion and MicroRNA Dysregulation in Multiple System Atrophy: A Review.International journal of molecular sciences, , Dec-01, Volume: 23, Issue:23, 2022
Sesquiterpenoids isolated from davana (Artemisia pallens Wall. ex DC) mitigates parkinsonism in Caenorhabditis elegans disease model.Biochemical and biophysical research communications, , 06-18, Volume: 609, 2022
Gastric Enteric Glial Cells: A New Contributor to the Synucleinopathies in the MPTP-Induced Parkinsonism Mouse.Molecules (Basel, Switzerland), , Nov-01, Volume: 27, Issue:21, 2022
Striatal synaptic bioenergetic and autophagic decline in premotor experimental parkinsonism.Brain : a journal of neurology, , 06-30, Volume: 145, Issue:6, 2022
Post-COVID-19 Parkinsonism and Parkinson's Disease Pathogenesis: The Exosomal Cargo Hypothesis.International journal of molecular sciences, , Aug-28, Volume: 23, Issue:17, 2022
Alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy.Translational neurodegeneration, , 02-07, Volume: 11, Issue:1, 2022
Phosphorylated α-Synuclein Deposits in Cutaneous Nerves of Early Parkinsonism.Journal of Parkinson's disease, , Volume: 12, Issue:8, 2022
Presence of Skin α-Synuclein Deposits Discriminates Parkinson's Disease from Progressive Supranuclear Palsy and Corticobasal Syndrome.Journal of Parkinson's disease, , Volume: 12, Issue:2, 2022
Long-standing multiple system atrophy-Parkinsonism with limbic and FTLD-type α-synuclein pathology.Neuropathology and applied neurobiology, , Volume: 48, Issue:3, 2022
Lippia grata essential oil complexed with β-cyclodextrin ameliorates biochemical and behavioral deficits in an animal model of progressive parkinsonism.Metabolic brain disease, , Volume: 37, Issue:7, 2022
Immunisation with UB-312 in the Thy1SNCA mouse prevents motor performance deficits and oligomeric α-synuclein accumulation in the brain and gut.Acta neuropathologica, , Volume: 143, Issue:1, 2022
Diterpene glycosides from Holothuria scabra exert the α-synuclein degradation and neuroprotection against α-synuclein-Mediated neurodegeneration in C. elegans model.Journal of ethnopharmacology, , Oct-28, Volume: 279, 2021
Direct targeting of wild-type glucocerebrosidase by antipsychotic quetiapine improves pathogenic phenotypes in Parkinson's disease models.JCI insight, , 10-08, Volume: 6, Issue:19, 2021
Is Multiple System Atrophy a Prion-like Disorder?International journal of molecular sciences, , Sep-18, Volume: 22, Issue:18, 2021
L-DOPA regulates α-synuclein accumulation in experimental parkinsonism.Neuropathology and applied neurobiology, , Volume: 47, Issue:4, 2021
Oral Administration of Silibinin Ameliorates Cognitive Deficits of Parkinson's Disease Mouse Model by Restoring Mitochondrial Disorders in Hippocampus.Neurochemical research, , Volume: 46, Issue:9, 2021
Reply to: "α-Synuclein (SNCA) A30G Mutation as a Cause of a Complex Phenotype Without Parkinsonism".Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:9, 2021
α-Synuclein (SNCA) A30G Mutation as a Cause of a Complex Phenotype Without Parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:9, 2021
Heterozygous GBA D409V and ATP13a2 mutations do not exacerbate pathological α-synuclein spread in the prodromal preformed fibrils model in young mice.Neurobiology of disease, , Volume: 159, 2021
A bibenzyl compound 20C protects rats against 6-OHDA-induced damage by regulating adaptive immunity associated molecules.International immunopharmacology, , Volume: 91, 2021
Wedelolactone Mitigates Parkinsonism Via Alleviating Oxidative Stress and Mitochondrial Dysfunction Through NRF2/SKN-1.Molecular neurobiology, , Volume: 58, Issue:1, 2021
Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders.Acta neuropathologica, , Volume: 142, Issue:6, 2021
Failure of Diphtheria Toxin Model to Induce Parkinson-Like Behavior in Mice.International journal of molecular sciences, , Aug-31, Volume: 22, Issue:17, 2021
Prodromal sensory neuropathy in Pink1Neuropathology and applied neurobiology, , Volume: 47, Issue:7, 2021
Toxic Feedback Loop Involving Iron, Reactive Oxygen Species, α-Synuclein and Neuromelanin in Parkinson's Disease and Intervention with Turmeric.Molecular neurobiology, , Volume: 58, Issue:11, 2021
Dose-related biphasic effect of the Parkinson's disease neurotoxin MPTP, on the spread, accumulation, and toxicity of α-synuclein.Neurotoxicology, , Volume: 84, 2021
Mechanistic insights into the protective effect of paracetamol against rotenone-induced Parkinson's disease in rats: Possible role of endocannabinoid system modulation.International immunopharmacology, , Volume: 94, 2021
PHB blocks endoplasmic reticulum stress and apoptosis induced by MPTP/MPPJournal of chemical neuroanatomy, , Volume: 113, 2021
Fecal Microbiota Transplantation Exerts a Protective Role in MPTP-Induced Parkinson's Disease via the TLR4/PI3K/AKT/NF-κB Pathway Stimulated by α-Synuclein.Neurochemical research, , Volume: 46, Issue:11, 2021
The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson's disease.Neurobiology of disease, , Volume: 153, 2021
HDAC6-mediated Hsp90 deacetylation reduces aggregation and toxicity of the protein alpha-synuclein by regulating chaperone-mediated autophagy.Neurochemistry international, , Volume: 149, 2021
GDNF signaling in subjects with minimal motor deficits and Parkinson's disease.Neurobiology of disease, , Volume: 153, 2021
Monoamine Oxidase-B Inhibition Facilitates α-Synuclein Secretion The Journal of neuroscience : the official journal of the Society for Neuroscience, , 09-01, Volume: 41, Issue:35, 2021
Neuroprotection of Exendin-4 by Enhanced Autophagy in a Parkinsonian Rat Model of α-Synucleinopathy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 18, Issue:2, 2021
Sgt1 Regulates α-Synuclein Subcellular Localization and Expression of Parkinson's Disease Related Genes, Biomolecules, , 11-11, Volume: 11, Issue:11, 2021
Memantine exerts neuroprotective effects by modulating α-synuclein transmission in a parkinsonian model.Experimental neurology, , Volume: 344, 2021
VPS35 D620N knockin mice recapitulate cardinal features of Parkinson's disease.Aging cell, , Volume: 20, Issue:5, 2021
Mechanisms of Neurodegeneration in Various Forms of Parkinsonism-Similarities and Differences.Cells, , 03-16, Volume: 10, Issue:3, 2021
Validation of α-Synuclein in L1CAM-Immunocaptured Exosomes as a Biomarker for the Stratification of Parkinsonian Syndromes.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:11, 2021
Neuroprotective effect of paeoniflorin in the mouse model of Parkinson's disease through α-synuclein/protein kinase C δ subtype signaling pathway.Neuroreport, , 12-08, Volume: 32, Issue:17, 2021
Interaction between coxsackievirus B3 infection and α-synuclein in models of Parkinson's disease.PLoS pathogens, , Volume: 17, Issue:10, 2021
Back and to the Future: From Neurotoxin-Induced to Human Parkinson's Disease Models.Current protocols in neuroscience, , Volume: 91, Issue:1, 2020
miR-30b protects nigrostriatal dopaminergic neurons from MPP(+)-induced neurotoxicity via SNCA.Brain and behavior, , Volume: 10, Issue:4, 2020
Astrocytes Protect Human Dopaminergic Neurons from α-Synuclein Accumulation and Propagation.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 11-04, Volume: 40, Issue:45, 2020
Alpha-Synuclein Protofibrils in Cerebrospinal Fluid: A Potential Biomarker for Parkinson's Disease.Journal of Parkinson's disease, , Volume: 10, Issue:4, 2020
Immunoregulation of microglial polarization: an unrecognized physiological function of α-synuclein.Journal of neuroinflammation, , Sep-17, Volume: 17, Issue:1, 2020
Emerging Targeted Therapeutics for Genetic Subtypes of Parkinsonism.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 17, Issue:4, 2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disease.International journal of molecular sciences, , Nov-10, Volume: 21, Issue:22, 2020
Propagated α-synucleinopathy recapitulates REM sleep behaviour disorder followed by parkinsonian phenotypes in mice.Brain : a journal of neurology, , 12-05, Volume: 143, Issue:11, 2020
Beneficial effects of cysteamine in Thy1-α-Syn mice and induced pluripotent stem cells with a SNCA gene triplication.Neurobiology of disease, , Volume: 145, 2020
Neuroprotection of Rotenone-Induced Parkinsonism by Ursolic Acid in PD Mouse Model.CNS & neurological disorders drug targets, , Volume: 19, Issue:7, 2020
Ropinirole silver nanocomposite attenuates neurodegeneration in the transgenic Drosophila melanogaster model of Parkinson's disease.Neuropharmacology, , 10-15, Volume: 177, 2020
Open questions on the nature of Parkinson's disease: from triggers to spreading pathology.Journal of medical genetics, , Volume: 57, Issue:2, 2020
Nigral overexpression of α-synuclein in a rat Parkinson's disease model indicates alterations in the enteric nervous system and the gut microbiome.Neurogastroenterology and motility, , Volume: 32, Issue:1, 2020
Systemic activation of Nrf2 pathway in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:1, 2020
α-Synuclein real-time quaking-induced conversion in the submandibular glands of Parkinson's disease patients.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:2, 2020
Alpha-synuclein oligomerization and dopaminergic degeneration occur synchronously in the brain and colon of MPTP-intoxicated parkinsonian monkeys.Neuroscience letters, , 01-18, Volume: 716, 2020
Simple and Complex Sugars in Parkinson's Disease: a Bittersweet Taste.Molecular neurobiology, , Volume: 57, Issue:7, 2020
Limited spread of pathology within the brainstem of α-synuclein BAC transgenic mice inoculated with preformed fibrils into the gastrointestinal tract.Neuroscience letters, , 01-18, Volume: 716, 2020
Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits.Neurobiology of disease, , Volume: 141, 2020
Neuroprotective function of Omi to α-synuclein-induced neurotoxicity.Neurobiology of disease, , Volume: 136, 2020
Acupuncture Inhibits the Increase in Alpha-Synuclein in Substantia Nigra in an MPTP- Induced Parkinsonism Mouse Model.Advances in experimental medicine and biology, , Volume: 1232, 2020
Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult.Neuron, , 03-04, Volume: 105, Issue:5, 2020
Alpha-synuclein at the nexus of genes and environment: the impact of environmental enrichment and stress on brain health and disease.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Ginsenoside Rb1 prevents MPTP-induced changes in hippocampal memory via regulation of the α-synuclein/PSD-95 pathway.Aging, , 04-04, Volume: 11, Issue:7, 2019
α-Synuclein real-time quaking-induced conversion in the cerebrospinal fluid of uncertain cases of parkinsonism.Annals of neurology, , Volume: 85, Issue:5, 2019
Histamine-4 receptor antagonist JNJ7777120 inhibits pro-inflammatory microglia and prevents the progression of Parkinson-like pathology and behaviour in a rat model.Brain, behavior, and immunity, , Volume: 76, 2019
The usual suspects, dopamine and alpha-synuclein, conspire to cause neurodegeneration.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:2, 2019
Acupuncture Inhibits the Increase in Alpha-Synuclein by Modulating SGK1 in an MPTP Induced Parkinsonism Mouse Model.The American journal of Chinese medicine, , Volume: 47, Issue:3, 2019
Progressive supranuclear palsy, multiple system atrophy and corticobasal degeneration.Handbook of clinical neurology, , Volume: 165, 2019
Phytochemicals Bridging Autophagy Induction and Alpha-Synuclein Degradation in Parkinsonism.International journal of molecular sciences, , Jul-03, Volume: 20, Issue:13, 2019
Neuroprotective role of kolaviron in striatal redo-inflammation associated with rotenone model of Parkinson's disease.Neurotoxicology, , Volume: 73, 2019
Juvenile parkinsonism: Differential diagnosis, genetics, and treatment.Parkinsonism & related disorders, , Volume: 67, 2019
α-synuclein oligomers enhance astrocyte-induced synapse formation through TGF-β1 signaling in a Parkinson's disease model.Journal of neurochemistry, , Volume: 150, Issue:2, 2019
Rebamipide Mitigates Impairments in Mitochondrial Function and Bioenergetics with α-Synuclein Pathology in 6-OHDA-Induced Hemiparkinson's Model in Rats.Neurotoxicity research, , Volume: 35, Issue:3, 2019
Tyrosol, a simple phenol from EVOO, targets multiple pathogenic mechanisms of neurodegeneration in a C. elegans model of Parkinson's disease.Neurobiology of aging, , Volume: 82, 2019
Female Sex and Brain-Selective Estrogen Benefit α-Synuclein Tetramerization and the PD-like Motor Syndrome in 3K Transgenic Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 09-18, Volume: 39, Issue:38, 2019
Coexisting Lewy body disease and clinical parkinsonism in frontotemporal lobar degeneration.Neurology, , 05-21, Volume: 92, Issue:21, 2019
Toll-like receptors and their therapeutic potential in Parkinson's disease and α-synucleinopathies.Brain, behavior, and immunity, , Volume: 81, 2019
Glial HMOX1 expression promotes central and peripheral α-synuclein dysregulation and pathogenicity in parkinsonian mice.Glia, , Volume: 67, Issue:9, 2019
Trichloroethylene and its metabolite TaClo lead to degeneration of substantia nigra dopaminergic neurones: Effects in wild type and human A30P mutant α-synuclein mice.Neuroscience letters, , 10-15, Volume: 711, 2019
Proteomics; applications in familial Parkinson's disease.Journal of neurochemistry, , Volume: 151, Issue:4, 2019
High lithium levels in tobacco may account for reduced incidences of both Parkinson's disease and melanoma in smokers through enhanced β-catenin-mediated activity.Medical hypotheses, , Volume: 131, 2019
Seeding of protein aggregation causes cognitive impairment in rat model of cortical synucleinopathy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:11, 2019
Thymoquinone prevents neurodegeneration against MPTP in vivo and modulates α-synuclein aggregation in vitro.Neurochemistry international, , Volume: 128, 2019
Aβ, Tau, and α-Synuclein aggregation and integrated role of PARK2 in the regulation and clearance of toxic peptides.Neuropeptides, , Volume: 78, 2019
Should Age at Onset of Parkinsonism be the End Point of Interest in Investigations of the Link Between Exosomal α-Synuclein and Manganese Exposure in Welders?Journal of occupational and environmental medicine, , Volume: 61, Issue:12, 2019
Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease.Neuron, , 08-21, Volume: 103, Issue:4, 2019
Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis.Nature communications, , 03-07, Volume: 10, Issue:1, 2019
Effects and mechanism of epigallocatechin-3-gallate on apoptosis and mTOR/AKT/GSK-3β pathway in substantia nigra neurons in Parkinson rats.Neuroreport, , 01-16, Volume: 30, Issue:2, 2019
Caffeic acid reduces A53T α-synuclein by activating JNK/Bcl-2-mediated autophagy in vitro and improves behaviour and protects dopaminergic neurons in a mouse model of Parkinson's disease.Pharmacological research, , Volume: 150, 2019
α-Synuclein Expression Is Preserved in Substantia Nigra GABAergic Fibers of Young and Aged Neurotoxin-Treated Rhesus Monkeys.Cell transplantation, , Volume: 28, Issue:4, 2019
Ultrasensitive Detection of Aggregated α-Synuclein in Glial Cells, Human Cerebrospinal Fluid, and Brain Tissue Using the RT-QuIC Assay: New High-Throughput Neuroimmune Biomarker Assay for Parkinsonian Disorders.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 14, Issue:3, 2019
Serotonergic pathology and disease burden in the premotor and motor phase of A53T α-synuclein parkinsonism: a cross-sectional study.The Lancet. Neurology, , Volume: 18, Issue:8, 2019
Serotonergic pathology and Braak's staging hypothesis in Parkinson's disease.The Lancet. Neurology, , Volume: 18, Issue:8, 2019
Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models.Neurobiology of disease, , Volume: 124, 2019
Chronic Mild Gut Inflammation Accelerates Brain Neuropathology and Motor Dysfunction in α-Synuclein Mutant Mice.Neuromolecular medicine, , Volume: 21, Issue:3, 2019
Activation of the immunoproteasome protects SH-SY5Y cells from the toxicity of rotenone.Neurotoxicology, , Volume: 73, 2019
Aquaporin-4 deficiency reduces TGF-β1 in mouse midbrains and exacerbates pathology in experimental Parkinson's disease.Journal of cellular and molecular medicine, , Volume: 23, Issue:4, 2019
GBA1-associated parkinsonism: new insights and therapeutic opportunities.Current opinion in neurology, , Volume: 32, Issue:4, 2019
Impairment of Nrf2- and Nitrergic-Mediated Gastrointestinal Motility in an MPTP Mouse Model of Parkinson's Disease.Digestive diseases and sciences, , Volume: 64, Issue:12, 2019
Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation.Molecular neurodegeneration, , 08-09, Volume: 13, Issue:1, 2018
Altered Volatile Organic Compound Profile in Transgenic Rats Bearing A53T Mutation of Human α-Synuclein: Comparison with Dopaminergic and Serotonergic Denervation.ACS chemical neuroscience, , 02-21, Volume: 9, Issue:2, 2018
Prion-like propagation of α-synuclein in the gut-brain axis.Brain research bulletin, , Volume: 140, 2018
Long non-coding RNA NEAT1 mediates the toxic of Parkinson's disease induced by MPTP/MPP+ via regulation of gene expression.Clinical and experimental pharmacology & physiology, , Volume: 45, Issue:8, 2018
Impact of DHA intake in a mouse model of synucleinopathy.Experimental neurology, , Volume: 301, Issue:Pt A, 2018
An unexpected improvement in spatial learning and memory ability in alpha-synuclein A53T transgenic mice.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 125, Issue:2, 2018
Parkinsonism due to A53E α-synuclein gene mutation: Clinical, genetic, epigenetic, and biochemical features.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:12, 2018
The Relevance of Iron in the Pathogenesis of Multiple System Atrophy: A Viewpoint.Journal of Alzheimer's disease : JAD, , Volume: 61, Issue:4, 2018
The different faces of the p. A53T alpha-synuclein mutation: A screening of Greek patients with parkinsonism and/or dementia.Neuroscience letters, , 04-13, Volume: 672, 2018
LncRNA SNHG1 promotes α-synuclein aggregation and toxicity by targeting miR-15b-5p to activate SIAH1 in human neuroblastoma SH-SY5Y cells.Neurotoxicology, , Volume: 68, 2018
Susceptibility MRI captures nigral pathology in patients with parkinsonian syndromes.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:9, 2018
When Do α-Synucleinopathies Start? An Epidemiological Timeline: A Review.JAMA neurology, , 04-01, Volume: 75, Issue:4, 2018
α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism.Molecular neurodegeneration, , 01-08, Volume: 13, Issue:1, 2018
Parkinson Diseases in the 2020s and Beyond: Replacing Clinico-Pathologic Convergence With Systems Biology Divergence.Journal of Parkinson's disease, , Volume: 8, Issue:s1, 2018
Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease.Neuron, , 10-10, Volume: 100, Issue:1, 2018
P75 Involved in the Ubiquitination of α-synuclein in Rotenone-based Parkinson's Disease Models.Neuroscience, , 09-15, Volume: 388, 2018
Neuroprotective effect of treadmill exercise possibly via regulation of lysosomal degradation molecules in mice with pharmacologically induced Parkinson's disease.The journal of physiological sciences : JPS, , Volume: 68, Issue:5, 2018
Modeling Parkinson's Disease in C. elegans.Journal of Parkinson's disease, , Volume: 8, Issue:1, 2018
Serum Response Factor Promotes Dopaminergic Neuron Survival via Activation of Beclin 1-Dependent Autophagy.Neuroscience, , 02-10, Volume: 371, 2018
DNAJC12: A molecular chaperone involved in proteostasis, PKU, biogenic amines metabolism and beyond?Molecular genetics and metabolism, , Volume: 123, Issue:3, 2018
Dynamic footprint based locomotion sway assessment in α-synucleinopathic mice using Fast Fourier Transform and Low Pass Filter.Journal of neuroscience methods, , 02-15, Volume: 296, 2018
Parkinson's disease-like burst firing activity in subthalamic nucleus induced by AAV-α-synuclein is normalized by LRRK2 modulation.Neurobiology of disease, , Volume: 116, 2018
Isolated nigral degeneration without pathological protein aggregation in autopsied brains with LRRK2 p.R1441H homozygous and heterozygous mutations.Acta neuropathologica communications, , 10-17, Volume: 6, Issue:1, 2018
Recent advances in neuropathology, biomarkers and therapeutic approach of multiple system atrophy.Journal of neurology, neurosurgery, and psychiatry, , Volume: 89, Issue:2, 2018
Genetics of Parkinson's disease and related disorders.Journal of medical genetics, , Volume: 55, Issue:2, 2018
MANF protects dopamine neurons and locomotion defects from a human α-synuclein induced Parkinson's disease model in C. elegans by regulating ER stress and autophagy pathways.Experimental neurology, , Volume: 308, 2018
Hydroxysafflor yellow A promotes α-synuclein clearance via regulating autophagy in rotenone-induced Parkinson's disease mice.Folia neuropathologica, , Volume: 56, Issue:2, 2018
RTP801 is a critical factor in the neurodegeneration process of A53T α-synuclein in a mouse model of Parkinson's disease under chronic restraint stress.British journal of pharmacology, , Volume: 175, Issue:4, 2018
[GBA mutations and Parkinson's disease].Sheng li xue bao : [Acta physiologica Sinica], , Jun-25, Volume: 70, Issue:3, 2018
Mutant A53T α-Synuclein Improves Rotarod Performance Before Motor Deficits and Affects Metabolic Pathways.Neuromolecular medicine, , Volume: 19, Issue:1, 2017
Deferiprone Rescues Behavioral Deficits Induced by Mild Iron Exposure in a Mouse Model of Alpha-Synuclein Aggregation.Neuromolecular medicine, , Volume: 19, Issue:2-3, 2017
Survival and Causes of Death Among People With Clinically Diagnosed Synucleinopathies With Parkinsonism: A Population-Based Study.JAMA neurology, , 07-01, Volume: 74, Issue:7, 2017
Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy.Neurobiology of disease, , Volume: 104, 2017
mTOR Signaling in Parkinson's Disease.Neuromolecular medicine, , Volume: 19, Issue:1, 2017
Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates.Acta neuropathologica communications, , 06-15, Volume: 5, Issue:1, 2017
Acrolein acts as a neurotoxin in the nigrostriatal dopaminergic system of rat: involvement of α-synuclein aggregation and programmed cell death.Scientific reports, , 04-12, Volume: 7, 2017
Decreased Expression of hsa-miR-4274 in Cerebrospinal Fluid of Normal Pressure Hydrocephalus Mimics with Parkinsonian Syndromes.Journal of Alzheimer's disease : JAD, , Volume: 56, Issue:1, 2017
Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice.Acta neuropathologica communications, , 03-14, Volume: 5, Issue:1, 2017
α-Synuclein and Parkinsonism: Updates and Future Perspectives.Current neurology and neuroscience reports, , Volume: 17, Issue:4, 2017
DNAJC12 and dopa-responsive nonprogressive parkinsonism.Annals of neurology, , Volume: 82, Issue:4, 2017
Identification of candidate cerebrospinal fluid biomarkers in parkinsonism using quantitative proteomics.Parkinsonism & related disorders, , Volume: 37, 2017
Propagation of pathological α-synuclein in marmoset brain.Acta neuropathologica communications, , Feb-02, Volume: 5, Issue:1, 2017
AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson's disease.Acta neuropathologica communications, , Feb-01, Volume: 5, Issue:1, 2017
Subcutaneous rotenone rat model of Parkinson's disease: Dose exploration study.Brain research, , 01-15, Volume: 1655, 2017
Neuropathology of genetic synucleinopathies with parkinsonism: Review of the literature.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:11, 2017
Effects of titanium dioxide nanoparticles exposure on parkinsonism in zebrafish larvae and PC12.Chemosphere, , Volume: 173, 2017
Allelic difference in Mhc2ta confers altered microglial activation and susceptibility to α-synuclein-induced dopaminergic neurodegeneration.Neurobiology of disease, , Volume: 106, 2017
Hereditary Parkinsonism-Associated Genetic Variations in PARK9 Locus Lead to Functional Impairment of ATPase Type 13A2.Current protein & peptide science, , Volume: 18, Issue:7, 2017
Sirtuin 3 rescues neurons through the stabilisation of mitochondrial biogenetics in the virally-expressing mutant α-synuclein rat model of parkinsonism.Neurobiology of disease, , Volume: 106, 2017
The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease.Acta neuropathologica communications, , 06-28, Volume: 5, Issue:1, 2017
Reassessment of subacute MPTP-treated mice as animal model of Parkinson's disease.Acta pharmacologica Sinica, , Volume: 38, Issue:10, 2017
Alpha-, Beta-, and Gamma-synuclein Quantification in Cerebrospinal Fluid by Multiple Reaction Monitoring Reveals Increased Concentrations in Alzheimer's and Creutzfeldt-Jakob Disease but No Alteration in Synucleinopathies.Molecular & cellular proteomics : MCP, , Volume: 15, Issue:10, 2016
Neurodegeneration in tauopathies and synucleinopathies.Revue neurologique, , Volume: 172, Issue:11, 2016
Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model.Acta neuropathologica communications, , 08-22, Volume: 4, Issue:1, 2016
Mesenchymal stem cells enhance α-synuclein clearance via M2 microglia polarization in experimental and human parkinsonian disorder.Acta neuropathologica, , Volume: 132, Issue:5, 2016
Autosomal dominant Parkinson's disease caused by SNCA duplications.Parkinsonism & related disorders, , Volume: 22 Suppl 1, 2016
α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.Human molecular genetics, , Mar-15, Volume: 25, Issue:6, 2016
Neuroprotection of inositol hexaphosphate and changes of mitochondrion mediated apoptotic pathway and α-synuclein aggregation in 6-OHDA induced parkinson's disease cell model.Brain research, , Feb-15, Volume: 1633, 2016
Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model by targeting α-synuclein abnormalities in the substantia nigra.Toxicology letters, , Jan-22, Volume: 243, 2016
Phenotypic spectrum of alpha-synuclein mutations: New insights from patients and cellular models.Parkinsonism & related disorders, , Volume: 22 Suppl 1, 2016
Delivery of Dual Drug Loaded Lipid Based Nanoparticles across the Blood-Brain Barrier Impart Enhanced Neuroprotection in a Rotenone Induced Mouse Model of Parkinson's Disease.ACS chemical neuroscience, , 12-21, Volume: 7, Issue:12, 2016
A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 07-13, Volume: 36, Issue:28, 2016
Role of cytochrome c in α-synuclein radical formation: implications of α-synuclein in neuronal death in Maneb- and paraquat-induced model of Parkinson's disease.Molecular neurodegeneration, , 11-24, Volume: 11, Issue:1, 2016
Is Multiple System Atrophy a New Prion Disorder?Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:3, 2016
Thiol Oxidation by Diamide Leads to Dopaminergic Degeneration and Parkinsonism Phenotype in Mice: A Model for Parkinson's Disease.Antioxidants & redox signaling, , 08-10, Volume: 25, Issue:5, 2016
High-content analysis of α-synuclein aggregation and cell death in a cellular model of Parkinson's disease.Journal of neuroscience methods, , Mar-01, Volume: 261, 2016
α-Synuclein vaccination modulates regulatory T cell activation and microglia in the absence of brain pathology.Journal of neuroinflammation, , Apr-07, Volume: 13, Issue:1, 2016
Levodopa-Induced Motor and Dopamine Receptor Changes in Caenorhabditis elegans Overexpressing Human Alpha-Synuclein.Neuro-degenerative diseases, , Volume: 16, Issue:3-4, 2016
Inhibition of Rho-kinase by Fasudil protects dopamine neurons and attenuates inflammatory response in an intranasal lipopolysaccharide-mediated Parkinson's model.The European journal of neuroscience, , Volume: 43, Issue:1, 2016
Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC α-synuclein transgenic rat model of Parkinson's disease.Neurobiology of disease, , Volume: 85, 2016
Transmission of α-synucleinopathy from olfactory structures deep into the temporal lobe.Molecular neurodegeneration, , 06-30, Volume: 11, Issue:1, 2016
Alterations in Activity-Dependent Neuroprotective Protein in Sporadic and Experimental Parkinson's Disease.Journal of Parkinson's disease, , Volume: 6, Issue:1, 2016
Pedunculopontine cell loss and protein aggregation direct microglia activation in parkinsonian rats.Brain structure & function, , Volume: 221, Issue:4, 2016
Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism.Proceedings of the National Academy of Sciences of the United States of America, , Apr-12, Volume: 113, Issue:15, 2016
The Bcl-2 homologue Buffy rescues α-synuclein-induced Parkinson disease-like phenotypes in Drosophila.BMC neuroscience, , 05-18, Volume: 17, Issue:1, 2016
Geniposide reduces α-synuclein by blocking microRNA-21/lysosome-associated membrane protein 2A interaction in Parkinson disease models.Brain research, , 08-01, Volume: 1644, 2016
An 11-mer Amyloid Beta Peptide Fragment Provokes Chemical Mutations and Parkinsonian Biomarker Aggregation in Dopaminergic Cells: A Novel Road Map for "Transfected" Parkinson's.ACS chemical neuroscience, , 11-16, Volume: 7, Issue:11, 2016
Comparison between α-synuclein wild-type and A53T mutation in a progressive Parkinson's disease model.Biochemical and biophysical research communications, , Sep-04, Volume: 464, Issue:4, 2015
Environment-contact administration of rotenone: A new rodent model of Parkinson's disease.Behavioural brain research, , Nov-01, Volume: 294, 2015
α-Synuclein and nonhuman primate models of Parkinson's disease.Journal of neuroscience methods, , Nov-30, Volume: 255, 2015
Noradrenergic and serotonergic neurochemistry arising from intranasal inoculation with α-synuclein aggregates which incite parkinsonian-like symptoms.Behavioural brain research, , Feb-15, Volume: 279, 2015
α-Synuclein oligomers pump it up!The EMBO journal, , Oct-01, Volume: 34, Issue:19, 2015
Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease.Human molecular genetics, , Dec-01, Volume: 24, Issue:23, 2015
A Fluorescence Resonance Energy Transfer Assay For Monitoring α- Synclein Aggregation in a Caenorhabditis Elegans Model For Parkinson's Disease.CNS & neurological disorders drug targets, , Volume: 14, Issue:8, 2015
α-synuclein assemblies sequester neuronal α3-Na+/K+-ATPase and impair Na+ gradient.The EMBO journal, , Oct-01, Volume: 34, Issue:19, 2015
α-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson's disease occurs independent of ATP13A2 (PARK9).Neurobiology of disease, , Volume: 73, 2015
MicroRNA-214 participates in the neuroprotective effect of Resveratrol via inhibiting α-synuclein expression in MPTP-induced Parkinson's disease mouse.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 74, 2015
Fractalkine over expression suppresses α-synuclein-mediated neurodegeneration.Molecular therapy : the journal of the American Society of Gene Therapy, , Volume: 23, Issue:1, 2015
α-Synuclein staging in the amygdala of a Parkinson's disease model: cell types involved.The European journal of neuroscience, , Volume: 41, Issue:1, 2015
Tea polyphenols alleviate motor impairments, dopaminergic neuronal injury, and cerebral α-synuclein aggregation in MPTP-intoxicated parkinsonian monkeys.Neuroscience, , Feb-12, Volume: 286, 2015
Clinicopathological Study of Patients With C9ORF72-Associated Frontotemporal Dementia Presenting With Delusions.Journal of geriatric psychiatry and neurology, , Volume: 28, Issue:2, 2015
Gaucher-Associated Parkinsonism.Cellular and molecular neurobiology, , Volume: 35, Issue:6, 2015
Rotenone impairs autophagic flux and lysosomal functions in Parkinson's disease.Neuroscience, , Jan-22, Volume: 284, 2015
Expanding the prion disease repertoire.Proceedings of the National Academy of Sciences of the United States of America, , Sep-22, Volume: 112, Issue:38, 2015
α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Apr-08, Volume: 35, Issue:14, 2015
Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice.Molecular neurodegeneration, , Jul-30, Volume: 10, 2015
Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.Proceedings of the National Academy of Sciences of the United States of America, , Sep-22, Volume: 112, Issue:38, 2015
Increased 14-3-3 phosphorylation observed in Parkinson's disease reduces neuroprotective potential of 14-3-3 proteins.Neurobiology of disease, , Volume: 79, 2015
Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy.Molecular neurodegeneration, , Mar-19, Volume: 10, 2015
Parkinson's disease and alpha-synucleinopathies: from arising pathways to therapeutic challenge.Central nervous system agents in medicinal chemistry, , Volume: 15, Issue:2, 2015
A Genetic Mouse Model of Parkinson's Disease Shows Involuntary Movements and Increased Postsynaptic Sensitivity to Apomorphine.Molecular neurobiology, , Volume: 52, Issue:3, 2015
Link between the SNCA gene and parkinsonism.Neurobiology of aging, , Volume: 36, Issue:3, 2015
VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jul-22, Volume: 35, Issue:29, 2015
Toward peptide-based inhibitors as therapies for Parkinson's disease.Future medicinal chemistry, , Volume: 7, Issue:16, 2015
Cyclosporine A and MnTMPyP Alleviate α-Synuclein Expression and Aggregation in Cypermethrin-Induced Parkinsonism.Molecular neurobiology, , Volume: 52, Issue:3, 2015
Gastric motor dysfunctions in Parkinson's disease: Current pre-clinical evidence.Parkinsonism & related disorders, , Volume: 21, Issue:12, 2015
shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model.The Journal of clinical investigation, , Jul-01, Volume: 125, Issue:7, 2015
Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease.Human molecular genetics, , Oct-15, Volume: 24, Issue:R1, 2015
GSK-3β dysregulation contributes to parkinson's-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and α-synuclein.Cell death and differentiation, , Volume: 22, Issue:5, 2015
Survival in synucleinopathies: A prospective cohort study.Neurology, , Nov-03, Volume: 85, Issue:18, 2015
Multiple sclerosis and Parkinson's disease: the two faces of neurodegeneration. Report of the first Greek case and review of the literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 36, Issue:12, 2015
Understanding Caffeine's Role in Attenuating the Toxicity of α-Synuclein Aggregates: Implications for Risk of Parkinson's Disease.ACS chemical neuroscience, , Sep-16, Volume: 6, Issue:9, 2015
A 6.4 Mb duplication of the α-synuclein locus causing frontotemporal dementia and Parkinsonism: phenotype-genotype correlations.JAMA neurology, , Volume: 71, Issue:9, 2014
[Clinical picture and diagnostic criteria of multiple system atrophy].Rinsho shinkeigaku = Clinical neurology, , Volume: 54, Issue:12, 2014
Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental Parkinson's disease.Neurobiology of disease, , Volume: 69, 2014
Molecular inscription of environmental information into protein suprastructures: temperature effects on unit assembly of α-synuclein oligomers into polymorphic amyloid fibrils.The Biochemical journal, , Dec-01, Volume: 464, Issue:2, 2014
Intranasal administration of alpha-synuclein aggregates: a Parkinson's disease model with behavioral and neurochemical correlates.Behavioural brain research, , Apr-15, Volume: 263, 2014
Correlation between the biochemical pathways altered by mutated parkinson-related genes and chronic exposure to manganese.Neurotoxicology, , Volume: 44, 2014
Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jul-09, Volume: 34, Issue:28, 2014
Deciphering the glycolipid code of Alzheimer's and Parkinson's amyloid proteins allowed the creation of a universal ganglioside-binding peptide.PloS one, , Volume: 9, Issue:8, 2014
Ellagic acid mitigates SNO-PDI induced aggregation of Parkinsonian biomarkers.ACS chemical neuroscience, , Dec-17, Volume: 5, Issue:12, 2014
Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice.Neurobiology of disease, , Volume: 69, 2014
Multiple system atrophy of the cerebellar type: clinical state of the art.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:3, 2014
The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset.Acta neuropathologica, , Volume: 127, Issue:5, 2014
Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease.Neurobiology of disease, , Volume: 64, 2014
Immunolocalization of human alpha-synuclein in the Thy1-aSyn ("Line 61") transgenic mouse line.Neuroscience, , Sep-26, Volume: 277, 2014
Zn²⁺ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation.Human molecular genetics, , Jun-01, Volume: 23, Issue:11, 2014
Acetylcorynoline attenuates dopaminergic neuron degeneration and α-synuclein aggregation in animal models of Parkinson's disease.Neuropharmacology, , Volume: 82, 2014
Mosaicism of alpha-synuclein gene rearrangements: report of two unrelated cases of early-onset parkinsonism.Parkinsonism & related disorders, , Volume: 20, Issue:5, 2014
Long-term heat shock proteins (HSPs) induction by carbenoxolone improves hallmark features of Parkinson's disease in a rotenone-based model.Neuropharmacology, , Volume: 79, 2014
ATP13A2/PARK9 regulates secretion of exosomes and α-synuclein.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-12, Volume: 34, Issue:46, 2014
Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons.Neurobiology of disease, , Volume: 69, 2014
Multifunctional D2/D3 agonist D-520 with high in vivo efficacy: modulator of toxicity of alpha-synuclein aggregates.ACS chemical neuroscience, , Aug-20, Volume: 5, Issue:8, 2014
CSF α-synuclein and UCH-L1 levels in Parkinson's disease and atypical parkinsonian disorders.Parkinsonism & related disorders, , Volume: 20, Issue:4, 2014
Non-motor parkinsonian pathology in aging A53T α-synuclein mice is associated with progressive synucleinopathy and altered enzymatic function.Journal of neurochemistry, , Volume: 128, Issue:4, 2014
Telmisartan attenuates MPTP induced dopaminergic degeneration and motor dysfunction through regulation of α-synuclein and neurotrophic factors (BDNF and GDNF) expression in C57BL/6J mice.Neuropharmacology, , Volume: 73, 2013
Glucocerebrosidase in the pathogenesis and treatment of Parkinson disease.Proceedings of the National Academy of Sciences of the United States of America, , Feb-26, Volume: 110, Issue:9, 2013
The association between ß-glucocerebrosidase mutations and parkinsonism.Current neurology and neuroscience reports, , Volume: 13, Issue:8, 2013
Parkinsonism, dementia and glucocerebrosidase mutations.Journal of neurology, , Volume: 260, Issue:5, 2013
Alpha-synuclein gene duplication: marked intrafamilial variability in two novel pedigrees.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:6, 2013
Tyrosine kinase inhibition facilitates autophagic SNCA/α-synuclein clearance.Autophagy, , Volume: 9, Issue:8, 2013
Reynosin protects against neuronal toxicity in dopamine-induced SH-SY5Y cells and 6-hydroxydopamine-lesioned rats as models of Parkinson's disease: Reciprocal up-regulation of E6-AP and down-regulation of α-synuclein.Brain research, , Aug-02, Volume: 1524, 2013
Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of α-synuclein in Parkinson's disease models.Human molecular genetics, , Aug-15, Volume: 22, Issue:16, 2013
Potential neuroprotective effect of ibuprofen, insights from the mice model of Parkinson's disease.Pharmacological reports : PR, , Volume: 65, Issue:5, 2013
An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker.NMR in biomedicine, , Volume: 26, Issue:1, 2013
Differentiation of progressive supranuclear palsy: clinical, imaging and laboratory tools.Acta neurologica Scandinavica, , Volume: 127, Issue:5, 2013
Alpha-synuclein aggregates in epicardial fat tissue in living subjects without parkinsonism.Parkinsonism & related disorders, , Volume: 19, Issue:1, 2013
[Α-synuclein as a biomarker for early diagnosis of Parkinsonism].Rinsho shinkeigaku = Clinical neurology, , Volume: 53, Issue:11, 2013
SUMO and Parkinson's disease.Neuromolecular medicine, , Volume: 15, Issue:4, 2013
Increased SUMO-1 expression in the unilateral rotenone-lesioned mouse model of Parkinson's disease.Neuroscience letters, , Jun-07, Volume: 544, 2013
Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment.Experimental neurology, , Volume: 240, 2013
Direct detection of alpha synuclein oligomers in vivo.Acta neuropathologica communications, , May-09, Volume: 1, 2013
Decreased parkin solubility is associated with impairment of autophagy in the nigrostriatum of sporadic Parkinson's disease.Neuroscience, , Mar-01, Volume: 232, 2013
Movement disorders in 2012: Advancing research towards novel therapeutic approaches.Nature reviews. Neurology, , Volume: 9, Issue:2, 2013
Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies.Proceedings of the National Academy of Sciences of the United States of America, , Feb-26, Volume: 110, Issue:9, 2013
Immune effects of optimized DNA vaccine and protective effects in a MPTP model of Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 34, Issue:9, 2013
Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits.Human molecular genetics, , May-15, Volume: 22, Issue:10, 2013
Parkinson's disease and α-synuclein: passing it on.CNS & neurological disorders drug targets, , Feb-01, Volume: 12, Issue:1, 2013
Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model.Proceedings of the National Academy of Sciences of the United States of America, , Oct-15, Volume: 110, Issue:42, 2013
Primary progressive aphasia with parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:6, 2013
A30P α-synuclein impairs dopaminergic fiber regeneration and interacts with L-DOPA replacement in MPTP-treated mice.Neurobiology of disease, , Volume: 45, Issue:1, 2012
Variant in the 3' region of SNCA associated with Parkinson's disease and serum α-synuclein levels.Journal of neurology, , Volume: 259, Issue:3, 2012
Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-21, Volume: 32, Issue:12, 2012
Pathobiochemical effect of acylated steryl-β-glucoside on aggregation and cytotoxicity of α-synuclein.Neurochemical research, , Volume: 37, Issue:6, 2012
DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats.Brain research bulletin, , Sep-01, Volume: 88, Issue:6, 2012
Widespread Lewy body and tau accumulation in childhood and adult onset dystonia-parkinsonism cases with PLA2G6 mutations.Neurobiology of aging, , Volume: 33, Issue:4, 2012
α-Synuclein pathology in the amyotrophic lateral sclerosis/parkinsonism dementia complex in the Kii Peninsula, Japan.Journal of neuropathology and experimental neurology, , Volume: 71, Issue:7, 2012
Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease.Brain : a journal of neurology, , Volume: 135, Issue:Pt 7, 2012
Autosomal dominant parkinsonism: its etiologies and differential diagnoses.Parkinsonism & related disorders, , Volume: 18 Suppl 1, 2012
Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jul-04, Volume: 32, Issue:27, 2012
Overexpression of parkin ameliorates dopaminergic neurodegeneration induced by 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.PloS one, , Volume: 7, Issue:6, 2012
Late-onset Parkinsonism in NFκB/c-Rel-deficient mice.Brain : a journal of neurology, , Volume: 135, Issue:Pt 9, 2012
A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease.British journal of pharmacology, , Volume: 166, Issue:3, 2012
Update on genetics of parkinsonism.Neuro-degenerative diseases, , Volume: 10, Issue:1-4, 2012
Toxic equine parkinsonism: an immunohistochemical study of 10 horses with nigropallidal encephalomalacia.Veterinary pathology, , Volume: 49, Issue:2, 2012
Paraquat, but not maneb, induces synucleinopathy and tauopathy in striata of mice through inhibition of proteasomal and autophagic pathways.PloS one, , Volume: 7, Issue:1, 2012
Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice.Science (New York, N.Y.), , Nov-16, Volume: 338, Issue:6109, 2012
Young-onset parkinsonism due to homozygous duplication of α-synuclein in a consanguineous family.Movement disorders : official journal of the Movement Disorder Society, , Volume: 27, Issue:14, 2012
Emerging neurotoxic mechanisms in environmental factors-induced neurodegeneration.Neurotoxicology, , Volume: 33, Issue:4, 2012
Lithium protects against oxidative stress-mediated cell death in α-synuclein-overexpressing in vitro and in vivo models of Parkinson's disease.Journal of neuroscience research, , Volume: 89, Issue:10, 2011
Effect of Ser-129 phosphorylation on interaction of α-synuclein with synaptic and cellular membranes.The Journal of biological chemistry, , Oct-14, Volume: 286, Issue:41, 2011
Exploring the link between glucocerebrosidase mutations and parkinsonism.Trends in molecular medicine, , Volume: 17, Issue:9, 2011
An α-synuclein AAV gene silencing vector ameliorates a behavioral deficit in a rat model of Parkinson's disease, but displays toxicity in dopamine neurons.Brain research, , Jun-13, Volume: 1395, 2011
Mice lacking major brain gangliosides develop parkinsonism.Neurochemical research, , Volume: 36, Issue:9, 2011
Transfer of host-derived α synuclein to grafted dopaminergic neurons in rat.Neurobiology of disease, , Volume: 43, Issue:3, 2011
Spinal cord and parkinsonism: neuromorphological evidences in humans and experimental studies.Journal of chemical neuroanatomy, , Volume: 42, Issue:4, 2011
Chronic exposure to manganese decreases striatal dopamine turnover in human alpha-synuclein transgenic mice.Neuroscience, , Apr-28, Volume: 180, 2011
New insights into atypical parkinsonism.Current opinion in neurology, , Volume: 24, Issue:4, 2011
Direct MRI-guided stereotaxic viral mediated gene transfer of alpha-synuclein in the Göttingen minipig CNS.Acta neurobiologiae experimentalis, , Volume: 71, Issue:4, 2011
Interference of alpha-synuclein with cAMP/PKA-dependent CREB signaling for tyrosine hydroxylase gene expression in SK-N-BE(2)C cells.Archives of pharmacal research, , Volume: 34, Issue:5, 2011
Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease.BMC neuroscience, , Aug-03, Volume: 12, 2011
A family with Parkinsonism, essential tremor, restless legs syndrome, and depression.Neurology, , May-10, Volume: 76, Issue:19, 2011
Age and α-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling.Neurobiology of disease, , Volume: 44, Issue:2, 2011
Olfactory neuron-specific expression of A30P α-synuclein exacerbates dopamine deficiency and hyperactivity in a novel conditional model of early Parkinson's disease stages.Neurobiology of disease, , Volume: 44, Issue:2, 2011
Non-invasive evaluation of nigrostriatal neuropathology in a proteasome inhibitor rodent model of Parkinson's disease.BMC neuroscience, , Jan-05, Volume: 11, 2010
Identifying PD-causing genes and genetic susceptibility factors: current approaches and future prospects.Progress in brain research, , Volume: 183, 2010
MPTP-induced parkinsonism extends to a subclass of TH-positive neurons in the gut.Brain research, , Oct-08, Volume: 1355, 2010
Vulnerability of peripheral catecholaminergic neurons to MPTP is not regulated by alpha-synuclein.Neurobiology of disease, , Volume: 38, Issue:1, 2010
Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau.BioEssays : news and reviews in molecular, cellular and developmental biology, , Volume: 32, Issue:3, 2010
Roll on genetics of PARK and Parkinsonism in the developing world.Journal of neurology, neurosurgery, and psychiatry, , Volume: 81, Issue:2, 2010
Clinical implications of gene discovery in Parkinson's disease and parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Volume: 25 Suppl 1, 2010
Evaluation of the Braak staging scheme for Parkinson's disease: introduction to a panel presentation.Movement disorders : official journal of the Movement Disorder Society, , Volume: 25 Suppl 1, 2010
Oral administration of rotenone using a gavage and image analysis of alpha-synuclein inclusions in the enteric nervous system.Journal of visualized experiments : JoVE, , Oct-26, Issue:44, 2010
alpha-Synuclein- and MPTP-generated rodent models of Parkinson's disease and the study of extracellular striatal dopamine dynamics: a microdialysis approach.CNS & neurological disorders drug targets, , Volume: 9, Issue:4, 2010
α-Synuclein transgenic mice reveal compensatory increases in Parkinson's disease-associated proteins DJ-1 and parkin and have enhanced α-synuclein and PINK1 levels after rotenone treatment.Journal of molecular neuroscience : MN, , Volume: 42, Issue:2, 2010
A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death.Neurobiology of aging, , Volume: 31, Issue:1, 2010
Forebrain overexpression of alpha-synuclein leads to early postnatal hippocampal neuron loss and synaptic disruption.Experimental neurology, , Volume: 221, Issue:1, 2010
alpha-Synuclein multiplication analysis in Italian familial Parkinson disease.Parkinsonism & related disorders, , Volume: 16, Issue:3, 2010
Baicalein reduces E46K alpha-synuclein aggregation in vitro and protects cells against E46K alpha-synuclein toxicity in cell models of familiar Parkinsonism.Journal of neurochemistry, , Volume: 114, Issue:2, 2010
Juvenile parkinsonism.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, , Volume: 13, Issue:3, 2009
Degeneration in different parkinsonian syndromes relates to astrocyte type and astrocyte protein expression.Journal of neuropathology and experimental neurology, , Volume: 68, Issue:10, 2009
The nigrostriatal pathway in Creutzfeldt-Jakob disease.Journal of neuropathology and experimental neurology, , Volume: 68, Issue:7, 2009
A highly reproducible rotenone model of Parkinson's disease.Neurobiology of disease, , Volume: 34, Issue:2, 2009
Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models.Nature chemical biology, , Volume: 5, Issue:9, 2009
Inhibitors of protein aggregation and toxicity.Biochemical Society transactions, , Volume: 37, Issue:Pt 4, 2009
Lipid bilayer disruption by oligomeric alpha-synuclein depends on bilayer charge and accessibility of the hydrophobic core.Biochimica et biophysica acta, , Volume: 1788, Issue:6, 2009
DnaJB6 is present in the core of Lewy bodies and is highly up-regulated in parkinsonian astrocytes.Journal of neuroscience research, , Volume: 87, Issue:1, 2009
Subchronic infusion of the product of inflammation prostaglandin J2 models sporadic Parkinson's disease in mice.Journal of neuroinflammation, , Jul-25, Volume: 6, 2009
Neuroanatomy and pathology of sporadic Parkinson's disease.Advances in anatomy, embryology, and cell biology, , Volume: 201, 2009
Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease?Movement disorders : official journal of the Movement Disorder Society, , Apr-30, Volume: 24, Issue:6, 2009
Familial Parkinsonism and early onset Parkinson's disease in a Brazilian movement disorders clinic: phenotypic characterization and frequency of SNCA, PRKN, PINK1, and LRRK2 mutations.Movement disorders : official journal of the Movement Disorder Society, , Apr-15, Volume: 24, Issue:5, 2009
The ALS/PDC syndrome of Guam and the cycad hypothesis.Neurology, , Feb-03, Volume: 72, Issue:5, 2009
Alpha-synuclein pathology and Parkinsonism associated with POLG1 mutations and multiple mitochondrial DNA deletions.Neuropathology and applied neurobiology, , Volume: 35, Issue:1, 2009
Neuroprotective effect of the antiparkinsonian drug pramipexole against nigrostriatal dopaminergic degeneration in rotenone-treated mice.Neurochemistry international, , Volume: 55, Issue:8, 2009
Mendelian forms of Parkinson's disease.Biochimica et biophysica acta, , Volume: 1792, Issue:7, 2009
Parkinsonism in hiv-infected patients on highly active antiretroviral therapy.Neurology, , Aug-04, Volume: 73, Issue:5, 2009
Molecular basis of Parkinson's disease.Neuroreport, , Jan-28, Volume: 20, Issue:2, 2009
Alpha-synuclein gene rearrangements in dominantly inherited parkinsonism: frequency, phenotype, and mechanisms.Archives of neurology, , Volume: 66, Issue:1, 2009
[Frontier researches for the development of molecular-targeted therapies for familial Parkinson disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 61, Issue:8, 2009
[Analysis of the alpha-synuclein gene dosage variation associated with autosomal dominant form of ParkinsonTs disease].Genetika, , Volume: 45, Issue:4, 2009
Persistent short-term memory defects following sleep deprivation in a drosophila model of Parkinson disease.Sleep, , Volume: 32, Issue:8, 2009
Curvature dynamics of alpha-synuclein familial Parkinson disease mutants: molecular simulations of the micelle- and bilayer-bound forms.The Journal of biological chemistry, , Mar-13, Volume: 284, Issue:11, 2009
CD4+ T cells mediate cytotoxicity in neurodegenerative diseases.The Journal of clinical investigation, , Volume: 119, Issue:1, 2009
The association between mutations in the lysosomal protein glucocerebrosidase and parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Aug-15, Volume: 24, Issue:11, 2009
Protection against paraquat and A53T alpha-synuclein toxicity by cabergoline is partially mediated by dopamine receptors.Journal of the neurological sciences, , Mar-15, Volume: 278, Issue:1-2, 2009
The lipid peroxidation metabolite 4-oxo-2-nonenal cross-links alpha-synuclein causing rapid formation of stable oligomers.Biochemical and biophysical research communications, , Jan-23, Volume: 378, Issue:4, 2009
Striatal neuroinflammation promotes Parkinsonism in rats.PloS one, , Volume: 4, Issue:5, 2009
Parkin and PINK1 parkinsonism may represent nigral mitochondrial cytopathies distinct from Lewy body Parkinson's disease.Parkinsonism & related disorders, , Volume: 15, Issue:10, 2009
Clinical and pathological characteristics of patients with leucine-rich repeat kinase-2 mutations.Movement disorders : official journal of the Movement Disorder Society, , Jan-15, Volume: 24, Issue:1, 2009
Genotypic and phenotypic characteristics of Dutch patients with early onset Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Jan-30, Volume: 24, Issue:2, 2009
Parkinson's disease.Lancet (London, England), , Jun-13, Volume: 373, Issue:9680, 2009
Mutation analyses in amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula, Japan.Movement disorders : official journal of the Movement Disorder Society, , Dec-15, Volume: 23, Issue:16, 2008
Second consensus statement on the diagnosis of multiple system atrophy.Neurology, , Aug-26, Volume: 71, Issue:9, 2008
Review: Familial Parkinson's disease--genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease.Neuropathology and applied neurobiology, , Volume: 34, Issue:3, 2008
Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementia.Archives of neurology, , Volume: 65, Issue:4, 2008
High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in a Drosophila model of Parkinson's disease.Journal of neuroscience research, , Volume: 86, Issue:9, 2008
Enduring involvement of tau, beta-amyloid, alpha-synuclein, ubiquitin and TDP-43 pathology in the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam (ALS/PDC).Acta neuropathologica, , Volume: 116, Issue:6, 2008
Value of genetic models in understanding the cause and mechanisms of Parkinson's disease.Current neurology and neuroscience reports, , Volume: 8, Issue:4, 2008
[Animal models of neurodegenerative diseases].Medecine sciences : M/S, , Volume: 23, Issue:2, 2007
Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication.Neurology, , Mar-20, Volume: 68, Issue:12, 2007
Screening for SNCA and LRRK2 mutations in Greek sporadic and autosomal dominant Parkinson's disease: identification of two novel LRRK2 variants.European journal of neurology, , Volume: 14, Issue:1, 2007
Analysis of alpha-synuclein, dopamine and parkin pathways in neuropathologically confirmed parkinsonian nigra.Acta neuropathologica, , Volume: 113, Issue:3, 2007
Expanding insights on the involvement of endoplasmic reticulum stress in Parkinson's disease.Antioxidants & redox signaling, , Volume: 9, Issue:5, 2007
Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.Journal of neurochemistry, , Volume: 101, Issue:6, 2007
alpha-Synuclein and its disease-related mutants interact differentially with the microtubule protein tau and associate with the actin cytoskeleton.Neurobiology of disease, , Volume: 26, Issue:3, 2007
Clinical genetics of Parkinson's disease and related disorders.Parkinsonism & related disorders, , Volume: 13 Suppl 3, 2007
Animal models in neurodegenerative diseases.Journal of neural transmission. Supplementum, , Issue:72, 2007
Quantitative proteomics identifies surfactant-resistant alpha-synuclein in cerebral cortex of Parkinsonism-dementia complex of Guam but not Alzheimer's disease or progressive supranuclear palsy.The American journal of pathology, , Volume: 171, Issue:3, 2007
Transduced Tat-alpha-synuclein protects against oxidative stress in vitro and in vivo.Journal of biochemistry and molecular biology, , May-31, Volume: 39, Issue:3, 2006
Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models.Science (New York, N.Y.), , Jul-21, Volume: 313, Issue:5785, 2006
Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-15, Volume: 26, Issue:46, 2006
Convergent roles of alpha-synuclein, DA metabolism, and the ubiquitin-proteasome system in nigrostriatal toxicity.Annals of the New York Academy of Sciences, , Volume: 1074, 2006
Role of DJ-1 in Parkinson's disease.Journal of molecular neuroscience : MN, , Volume: 29, Issue:3, 2006
Genetics of Parkinson's disease and parkinsonism.Annals of neurology, , Volume: 60, Issue:4, 2006
Parkinsonism, Lrrk2 G2019S, and tau neuropathology.Neurology, , Oct-24, Volume: 67, Issue:8, 2006
Parkinsonism genes: culprits and clues.Journal of neurochemistry, , Volume: 99, Issue:4, 2006
Dementia with Lewy bodies in an elderly Greek male due to alpha-synuclein gene mutation.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, , Volume: 13, Issue:9, 2006
Behavioral phenotypes and pharmacology in genetic mouse models of Parkinsonism.Behavioural pharmacology, , Volume: 17, Issue:5-6, 2006
Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Sep-27, Volume: 26, Issue:39, 2006
14-3-3eta is a novel regulator of parkin ubiquitin ligase.The EMBO journal, , Jan-11, Volume: 25, Issue:1, 2006
Mice lacking alpha-synuclein are resistant to mitochondrial toxins.Neurobiology of disease, , Volume: 21, Issue:3, 2006
Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system.Neurobiology of disease, , Volume: 22, Issue:2, 2006
Atypical parkinsonism combining alpha-synuclein inclusions and polyglucosan body disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20, Issue:2, 2005
Unaltered alpha-synuclein blood levels in juvenile Parkinsonism with a parkin exon 4 deletion.Neuroscience letters, , Feb-21, Volume: 374, Issue:3, 2005
Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , Mar-01, Volume: 102, Issue:9, 2005
Viral vector mediated overexpression of human alpha-synuclein in the nigrostriatal dopaminergic neurons: a new model for Parkinson's disease.CNS spectrums, , Volume: 10, Issue:3, 2005
The pathology of the substantia nigra in Alzheimer disease with extrapyramidal signs.Neurology, , Apr-26, Volume: 64, Issue:8, 2005
Abnormal sleep architecture is an early feature in the E46K familial synucleinopathy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20, Issue:10, 2005
Alpha-synuclein expression in the substantia nigra of MPTP-lesioned non-human primates.Neurobiology of disease, , Volume: 20, Issue:3, 2005
Familial mutants of alpha-synuclein with increased neurotoxicity have a destabilized conformation.The Journal of biological chemistry, , Sep-02, Volume: 280, Issue:35, 2005
In vivo models of multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and drug-induced rotational asymmetry in hemi-parkinsonian rats.Journal of neurochemistry, , Volume: 95, Issue:4, 2005
Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human alpha-synuclein.Neurobiology of disease, , Volume: 20, Issue:2, 2005
Marmoset monkey models of Parkinson's disease: which model, when and why?Brain research bulletin, , Dec-30, Volume: 68, Issue:3, 2005
Axonal transport of human alpha-synuclein slows with aging but is not affected by familial Parkinson's disease-linked mutations.Journal of neurochemistry, , Volume: 88, Issue:2, 2004
Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications.Annals of neurology, , Volume: 55, Issue:2, 2004
Occurrence of alpha-synuclein pathology in the cerebellum of Guamanian patients with parkinsonism-dementia complex.Acta neuropathologica, , Volume: 107, Issue:6, 2004
An overview of parkinsonian syndromes: data from the literature and from an Italian data-base.Sleep medicine, , Volume: 5, Issue:2, 2004
Abnormal alpha-synuclein interactions with Rab proteins in alpha-synuclein A30P transgenic mice.Journal of neuropathology and experimental neurology, , Volume: 63, Issue:4, 2004
Iron and alpha-synuclein in the substantia nigra of MPTP-treated mice: effect of neuroprotective drugs R-apomorphine and green tea polyphenol (-)-epigallocatechin-3-gallate.Journal of molecular neuroscience : MN, , Volume: 24, Issue:3, 2004
Phosphorylated alpha-synuclein in normal mouse brain.FEBS letters, , Aug-13, Volume: 572, Issue:1-3, 2004
Alpha-synuclein missense and multiplication mutations in autosomal dominant Parkinson's disease.Neuroscience letters, , Aug-26, Volume: 367, Issue:1, 2004
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[Analysis of alpha-synuclein and its significance].Nihon rinsho. Japanese journal of clinical medicine, , Volume: 62, Issue:9, 2004
Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.Experimental neurology, , Volume: 179, Issue:1, 2003
Gaucher disease associated with parkinsonism: four further case reports.American journal of medical genetics. Part A, , Feb-01, Volume: 116A, Issue:4, 2003
A broken alpha -helix in folded alpha -Synuclein.The Journal of biological chemistry, , Apr-25, Volume: 278, Issue:17, 2003
Alpha-synuclein overexpression protects against paraquat-induced neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Apr-15, Volume: 23, Issue:8, 2003
Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice.Neuroscience, , Volume: 118, Issue:4, 2003
[Recent neuropathology of parkinsonian syndromes].Revue neurologique, , Volume: 159, Issue:5 Pt 2, 2003
Alpha-synuclein up-regulates expression of caveolin-1 and down-regulates extracellular signal-regulated kinase activity in B103 neuroblastoma cells: role in the pathogenesis of Parkinson's disease.Journal of neurochemistry, , Volume: 85, Issue:6, 2003
Parkinson's disease and related alpha-synucleinopathies are brain amyloidoses.Annals of the New York Academy of Sciences, , Volume: 991, 2003
Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism.Neurology, , Jul-08, Volume: 61, Issue:1, 2003
Multiple system atrophy: an update.Movement disorders : official journal of the Movement Disorder Society, , Volume: 18 Suppl 6, 2003
Familial Parkinson's disease: a hint to elucidate the mechanisms of nigral degeneration.Journal of neurology, , Volume: 250 Suppl 3, 2003
Molecular pathways of neurodegeneration in Parkinson's disease.Science (New York, N.Y.), , Oct-31, Volume: 302, Issue:5646, 2003
[alpha-synuclein and Parkinson's disease].Seikagaku. The Journal of Japanese Biochemical Society, , Volume: 74, Issue:6, 2002
Familial diffuse Lewy body disease, eye movement abnormalities, and distribution of pathology.Archives of neurology, , Volume: 59, Issue:3, 2002
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Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease.Science (New York, N.Y.), , Feb-01, Volume: 295, Issue:5556, 2002
Molecular findings in familial Parkinson disease in Spain.Archives of neurology, , Volume: 59, Issue:6, 2002
Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam.The American journal of pathology, , Volume: 160, Issue:5, 2002
Familial Parkinson's disease. Alpha-synuclein and parkin.Advances in neurology, , Volume: 86, 2001
Analysis of alpha-synuclein, parkin, tau, and UCH-L1 in a Japanese family with autosomal dominant parkinsonism.European neurology, , Volume: 46, Issue:1, 2001
Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter.Neurobiology of disease, , Volume: 8, Issue:3, 2001
Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease.Science (New York, N.Y.), , Jul-13, Volume: 293, Issue:5528, 2001
Familial parkinsonism with synuclein pathology: clinical and PET studies of A30P mutation carriers.Neurology, , May-22, Volume: 56, Issue:10, 2001
Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice.Journal of neurochemistry, , Volume: 77, Issue:4, 2001
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Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr alpha-synuclein mutation.Annals of neurology, , Volume: 49, Issue:3, 2001
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Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult.Journal of neurochemistry, , Volume: 76, Issue:4, 2001
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Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex.Journal of neurochemistry, , Volume: 75, Issue:5, 2000
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alpha-synuclein and Parkinson's disease: the first roadblock.Journal of cellular and molecular medicine, , Volume: 10, Issue:4
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A macrophage-nanozyme delivery system for Parkinson's disease.Bioconjugate chemistry, , Volume: 18, Issue:5
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Possible Role of the Polyglutamine Elongation in Evolution of Amyloid-Related Evolvability.Journal of Huntington's disease, , Volume: 7, Issue:4, 2018
Abnormal Paraplegin Expression in Swollen Neurites, τ- and α-Synuclein Pathology in a Case of Hereditary Spastic Paraplegia SPG7 with an Ala510Val Mutation.International journal of molecular sciences, , Oct-21, Volume: 16, Issue:10, 2015
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A review on the cause-effect relationship between oxidative stress and toxic proteins in the pathogenesis of neurodegenerative diseases.Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, , Volume: 118, Issue:1
Psychiatric symptoms of frontotemporal dementia and subcortical (co-)pathology burden: new insights.Brain : a journal of neurology, , 01-05, Volume: 146, Issue:1, 2023
Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions.Acta neuropathologica communications, , 07-21, Volume: 9, Issue:1, 2021
Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated.Brain : a journal of neurology, , 07-01, Volume: 141, Issue:7, 2018
A Novel Tau Mutation in Exon 12, p.Q336H, Causes Hereditary Pick Disease.Journal of neuropathology and experimental neurology, , Volume: 74, Issue:11, 2015
[Molecular neuropathology of Non-Alzheimer dementia].Der Pathologe, , Volume: 29, Issue:6, 2008
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Identification of G-protein coupled receptor kinase 2 in paired helical filaments and neurofibrillary tangles.Journal of neuropathology and experimental neurology, , Volume: 65, Issue:12, 2006
Abnormal alpha-synuclein solubility, aggregation and nitration in the frontal cortex in Pick's disease.Neuroscience letters, , May-29, Volume: 400, Issue:1-2, 2006
Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease.Acta neuropathologica, , Volume: 107, Issue:6, 2004
Clusterin/apolipoprotein J is associated with cortical Lewy bodies: immunohistochemical study in cases with alpha-synucleinopathies.Acta neuropathologica, , Volume: 104, Issue:3, 2002
Pick's disease: alpha- and beta-synuclein-immunoreactive Pick bodies in the dentate gyrus.Acta neuropathologica, , Volume: 104, Issue:5, 2002
Stains for the differential diagnosis of degenerative dementias.Biotechnic & histochemistry : official publication of the Biological Stain Commission, , Volume: 74, Issue:6, 1999
A review on the cause-effect relationship between oxidative stress and toxic proteins in the pathogenesis of neurodegenerative diseases.Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, , Volume: 118, Issue:1
Juvenile parkinsonism: Differential diagnosis, genetics, and treatment.Parkinsonism & related disorders, , Volume: 67, 2019
Unusual α-synuclein and cerebellar pathologies in a case of hereditary myoclonus-dystonia without SGCE mutation.Neuropathology and applied neurobiology, , Volume: 41, Issue:6, 2015
Widespread Lewy body and tau accumulation in childhood and adult onset dystonia-parkinsonism cases with PLA2G6 mutations.Neurobiology of aging, , Volume: 33, Issue:4, 2012
Genetics of movement disorders: an abbreviated overview.Stereotactic and functional neurosurgery, , Volume: 77, Issue:1-4, 2001
'Under pressure': is there a link between orthostatic hypotension and cognitive impairment in α-synucleinopathies?Journal of neurology, neurosurgery, and psychiatry, , Volume: 87, Issue:12, 2016
Loss of PINK1 inhibits apoptosis by upregulating α-synuclein in inflammation-sensitized hypoxic-ischemic injury in the immature brains.Brain research, , 12-15, Volume: 1653, 2016
Neuronal SNCA transcription during Lewy body formation.Acta neuropathologica communications, , 11-23, Volume: 11, Issue:1, 2023
Lifelong constipation in Parkinson's disease and other clinically defined alpha-synucleinopathies: A population-based study in Southeast Minnesota.Parkinsonism & related disorders, , Volume: 107, 2023
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Evaluation of N- and O-Linked Indole Triazines for a Dual Effect on α-Synuclein and Tau Aggregation.ACS chemical neuroscience, , 11-01, Volume: 14, Issue:21, 2023
Kinetic parameters of alpha-synuclein seed amplification assay correlate with cognitive impairment in patients with Lewy body disorders.Acta neuropathologica communications, , 10-09, Volume: 11, Issue:1, 2023
Misfolded α-Synuclein in Cerebrospinal Fluid of Contact Sport Athletes.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:11, 2023
Viral-like TLR3 induction of cytokine networks and α-synuclein are reduced by complement C3 blockade in mouse brain.Scientific reports, , 09-13, Volume: 13, Issue:1, 2023
α-Synuclein Strains and Their Relevance to Parkinson's Disease, Multiple System Atrophy, and Dementia with Lewy Bodies.International journal of molecular sciences, , Jul-28, Volume: 24, Issue:15, 2023
Investigation of Inflammation in Lewy Body Dementia: A Systematic Scoping Review.International journal of molecular sciences, , Jul-28, Volume: 24, Issue:15, 2023
The variance in phosphorylated, insoluble ⍺-synuclein in humans, rats, and mice is not mainly driven by biological sex.Acta neuropathologica, , Volume: 146, Issue:4, 2023
Toward imaging of alpha-synuclein with PET.Cell, , 08-03, Volume: 186, Issue:16, 2023
Cognitive effects of Lewy body pathology in clinically unimpaired individuals.Nature medicine, , Volume: 29, Issue:8, 2023
Decreased DHA-containing phospholipids in the neocortex of dementia with Lewy bodies are associated with soluble AβBrain pathology (Zurich, Switzerland), , Volume: 33, Issue:6, 2023
More than meets the eye in Parkinson's disease and other synucleinopathies: from proteinopathy to lipidopathy.Acta neuropathologica, , Volume: 146, Issue:3, 2023
Clinical trials in dementia with Lewy bodies: the evolving concept of co-pathologies, patient selection and biomarkers.Current opinion in neurology, , 08-01, Volume: 36, Issue:4, 2023
The Mechanisms of the Roles of α-Synuclein, Amyloid-β, and Tau Protein in the Lewy Body Diseases: Pathogenesis, Early Detection, and Therapeutics.International journal of molecular sciences, , Jun-17, Volume: 24, Issue:12, 2023
Disease-Specific α-Synuclein Seeding in Lewy Body Disease and Multiple System Atrophy Are Preserved in Formaldehyde-Fixed Paraffin-Embedded Human Brain.Biomolecules, , 06-02, Volume: 13, Issue:6, 2023
Microbiome-gut-brain dysfunction in prodromal and symptomatic Lewy body diseases.Journal of neurology, , Volume: 270, Issue:2, 2023
Nigral Pathology Contributes to Microstructural Integrity of Striatal and Frontal Tracts in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:9, 2023
A 14-day pulse of PLX5622 modifies α-synucleinopathy in preformed fibril-infused aged mice of both sexes.Neurobiology of disease, , Volume: 184, 2023
Cellular processing of α-synuclein fibrils results in distinct physiological C-terminal truncations with a major cleavage site at residue Glu 114.The Journal of biological chemistry, , Volume: 299, Issue:7, 2023
Propagative α-synuclein seeds as serum biomarkers for synucleinopathies.Nature medicine, , Volume: 29, Issue:6, 2023
Parkinson's disease in a patient with olfactory hypoplasia: a model case of "body-first Lewy body disease" providing insights into the progression of α-synuclein accumulation.Journal of neurology, , Volume: 270, Issue:10, 2023
Neuropathology of incidental Lewy body & prodromal Parkinson's disease.Molecular neurodegeneration, , 05-12, Volume: 18, Issue:1, 2023
Proposal for a Biologic Staging System of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 13, Issue:3, 2023
The brain-first vs. body-first model of Parkinson's disease with comparison to alternative models.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 130, Issue:6, 2023
Identification of Novel α-Synuclein Assemblies in Lewy Body Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:1, 2023
Sigma-2 Receptors-From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases.International journal of molecular sciences, , Mar-26, Volume: 24, Issue:7, 2023
Plasma GFAP associates with secondary Alzheimer's pathology in Lewy body disease.Annals of clinical and translational neurology, , Volume: 10, Issue:5, 2023
Implications of DNA Methylation in Lewy Body Pathology.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:1, 2023
Serotonin in synucleinopathies.Behavioural brain research, , 05-08, Volume: 445, 2023
Phosphorylated α-synuclein in skin Schwann cells: a new biomarker for multiple system atrophy.Brain : a journal of neurology, , 03-01, Volume: 146, Issue:3, 2023
Biomarkers of diagnosis, prognosis, pathogenesis, response to therapy: Convergence or divergence? Lessons from Alzheimer's disease and synucleinopathies.Handbook of clinical neurology, , Volume: 192, 2023
Cross-sectional Associations of β-Amyloid, Tau, and Cerebrovascular Biomarkers With Neurodegeneration in Probable Dementia With Lewy Bodies.Neurology, , 02-21, Volume: 100, Issue:8, 2023
Seed amplification and RT-QuIC assays to investigate protein seed structures and strains.Cell and tissue research, , Volume: 392, Issue:1, 2023
[no title available]ACS chemical neuroscience, , 03-01, Volume: 14, Issue:5, 2023
On the Track of α-Synuclein in the Body: Skin Biopsies for Diagnosing Synucleinopathies?Neurology, , 04-11, Volume: 100, Issue:15, 2023
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Intracellular Accumulation of α-Synuclein Aggregates Promotes S-Nitrosylation of MAP1A Leading to Decreased NMDAR-Evoked Calcium Influx and Loss of Mature Synaptic Spines.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 12-14, Volume: 42, Issue:50, 2022
[Role of fatty acid-binding protein 7 and novel therapeutic approach in synucleinopathies].Nihon yakurigaku zasshi. Folia pharmacologica Japonica, , Volume: 157, Issue:6, 2022
[Development of therapeutic peptides for Lewy body diseases preventing α-synuclein propagation].Nihon yakurigaku zasshi. Folia pharmacologica Japonica, , Volume: 157, Issue:6, 2022
Inhibition of α-Synuclein Seeding-Dependent Aggregation by ssDNA Aptamers Specific to C-Terminally Truncated α-Synuclein Fibrils.ACS chemical neuroscience, , 12-07, Volume: 13, Issue:23, 2022
Cerebrospinal Fluid Alpha-Synuclein Improves the Differentiation between Dementia with Lewy Bodies and Alzheimer's Disease in Clinical Practice.International journal of molecular sciences, , Nov-04, Volume: 23, Issue:21, 2022
Aggregated Alpha-Synuclein Inclusions within the Nucleus Predict Impending Neuronal Cell Death in a Mouse Model of Parkinsonism.International journal of molecular sciences, , Dec-04, Volume: 23, Issue:23, 2022
Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders.Acta neuropathologica communications, , 11-12, Volume: 10, Issue:1, 2022
The Proteome of Neuromelanin Granules in Dementia with Lewy Bodies.Cells, , 11-09, Volume: 11, Issue:22, 2022
Human pericytes degrade diverse α-synuclein aggregates.PloS one, , Volume: 17, Issue:11, 2022
Exploring the link between GBA1 mutations and Dementia with Lewy bodies, A mini-review.Neuroscience and biobehavioral reviews, , Volume: 141, 2022
Perception of Fragmented Letters by Patients With Pathologically Confirmed Dementia With Lewy Bodies or Alzheimer Disease.Neurology, , 11-01, Volume: 99, Issue:18, 2022
Synucleinopathy in Amyotrophic Lateral Sclerosis: A Potential Avenue for Antisense Therapeutics?International journal of molecular sciences, , Aug-19, Volume: 23, Issue:16, 2022
Threonine Cavities Are Targetable Motifs That Control Alpha-Synuclein Fibril Growth.ACS chemical neuroscience, , 09-07, Volume: 13, Issue:17, 2022
Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology.Nature communications, , 08-22, Volume: 13, Issue:1, 2022
Lewy Body Disease Primate Model with α-Synuclein Propagation from the Olfactory Bulb.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:10, 2022
Natural speech markers of Alzheimer's disease co-pathology in Lewy body dementias.Parkinsonism & related disorders, , Volume: 102, 2022
Norovirus Intestinal Infection and Lewy Body Disease in an Older Patient with Acute Cognitive Impairment.International journal of molecular sciences, , Jul-29, Volume: 23, Issue:15, 2022
Alteration of Vesicle-Associated Membrane Protein-Binding Protein B in α-Synuclein Aggregates in Lewy Body Disease.Journal of neuropathology and experimental neurology, , 09-19, Volume: 81, Issue:10, 2022
Amitriptyline improves cognitive and neuronal function in a rat model that mimics dementia with lewy bodies.Behavioural brain research, , 10-28, Volume: 435, 2022
Involvement of autophagic protein DEF8 in Lewy bodies.Biochemical and biophysical research communications, , 10-01, Volume: 623, 2022
α-Synuclein Seed Amplification Assays for Diagnosing Synucleinopathies: The Way Forward.Neurology, , 08-02, Volume: 99, Issue:5, 2022
Parkinson's Disease Etiology: Insights and Associations with Phosphate Toxicity.International journal of molecular sciences, , Jul-22, Volume: 23, Issue:15, 2022
Recent advances in establishing fluid biomarkers for the diagnosis and differentiation of alpha-synucleinopathies - a mini review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 32, Issue:4, 2022
A versatile fluorescence-quenched substrate for quantitative measurement of glucocerebrosidase activity within live cells.Proceedings of the National Academy of Sciences of the United States of America, , 07-19, Volume: 119, Issue:29, 2022
α-Synuclein fibril-specific nanobody reduces prion-like α-synuclein spreading in mice.Nature communications, , 07-19, Volume: 13, Issue:1, 2022
Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies.Acta neuropathologica communications, , 07-06, Volume: 10, Issue:1, 2022
α-Synuclein molecular behavior and nigral proteomic profiling distinguish subtypes of Lewy body disorders.Acta neuropathologica, , Volume: 144, Issue:2, 2022
Performance of αSynuclein RT-QuIC in relation to neuropathological staging of Lewy body disease.Acta neuropathologica communications, , 06-22, Volume: 10, Issue:1, 2022
α-synucleinopathy exerts sex-dimorphic effects on the multipurpose DNA repair/redox protein APE1 in mice and humans.Progress in neurobiology, , Volume: 216, 2022
Immunogenicity of MultiTEP-Platform-Based Recombinant Protein Vaccine, PV-1950R, Targeting Three B-Cell Antigenic Determinants of Pathological α-Synuclein.International journal of molecular sciences, , May-29, Volume: 23, Issue:11, 2022
Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies.Acta neuropathologica communications, , 06-03, Volume: 10, Issue:1, 2022
The promise of amplification assays for accurate early detection of α-synucleinopathies: A review.Experimental gerontology, , Volume: 165, 2022
A case series of cutaneous phosphorylated α-synuclein in Long-COVID POTS.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 32, Issue:3, 2022
MCC950 ameliorates the dementia symptom at the early age of line M83 mouse and reduces hippocampal α-synuclein accumulation.Biochemical and biophysical research communications, , 06-30, Volume: 611, 2022
APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer's disease with Lewy body pathology.Acta neuropathologica, , Volume: 143, Issue:6, 2022
Axonal degeneration in the anterior insular cortex is associated with Alzheimer's co-pathology in Parkinson's disease and dementia with Lewy bodies.Translational neurodegeneration, , 12-07, Volume: 11, Issue:1, 2022
Gastrointestinal Biopsy Obtained During Cancer Screening, a Biological Marker for α-Synucleinopathy?Journal of neuropathology and experimental neurology, , 04-27, Volume: 81, Issue:5, 2022
Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups.Brain : a journal of neurology, , 06-03, Volume: 145, Issue:5, 2022
α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity.Proceedings of the National Academy of Sciences of the United States of America, , 04-12, Volume: 119, Issue:15, 2022
Leukotriene Signaling as a Target in α-Synucleinopathies.Biomolecules, , 02-23, Volume: 12, Issue:3, 2022
Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies.Acta neuropathologica communications, , 03-16, Volume: 10, Issue:1, 2022
Brain injections of glial cytoplasmic inclusions induce a multiple system atrophy-like pathology.Brain : a journal of neurology, , 04-29, Volume: 145, Issue:3, 2022
Cardiac Alpha-Synuclein Is Present in Alpha-Synucleinopathies.Journal of Parkinson's disease, , Volume: 12, Issue:4, 2022
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[Autonomic Dysfunction in Lewy Body Disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 74, Issue:3, 2022
Unique Lewy pathology in myotonic dystrophy type 1.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 42, Issue:2, 2022
S-Nitrosylation of p62 Inhibits Autophagic Flux to Promote α-Synuclein Secretion and Spread in Parkinson's Disease and Lewy Body Dementia.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 04-06, Volume: 42, Issue:14, 2022
Current Progress in the Development of Probes for Targeting α-Synuclein Aggregates.ACS chemical neuroscience, , 03-02, Volume: 13, Issue:5, 2022
Fluid markers of synapse degeneration in synucleinopathies.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 129, Issue:2, 2022
Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations.Acta neuropathologica, , Volume: 143, Issue:4, 2022
Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy.Proceedings of the National Academy of Sciences of the United States of America, , 02-08, Volume: 119, Issue:6, 2022
Impaired Sphingolipid Hydrolase Activities in Dementia with Lewy Bodies and Multiple System Atrophy.Molecular neurobiology, , Volume: 59, Issue:4, 2022
Quantifying regional α -synuclein, amyloid β, and tau accumulation in lewy body dementia.Annals of clinical and translational neurology, , Volume: 9, Issue:2, 2022
Infectious Agents as Potential Drivers of α-Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:3, 2022
Prion-like α-synuclein pathology in the brain of infants with Krabbe disease.Brain : a journal of neurology, , 05-24, Volume: 145, Issue:4, 2022
Elevated norepinephrine may interact with alpha-synuclein to promote Parkinson's disease and DLB.Acta neurologica Scandinavica, , Volume: 145, Issue:1, 2022
The role of cardiovascular autonomic failure in the differential diagnosis of α-synucleinopathies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 43, Issue:1, 2022
Pathology-associated change in levels and localization of SIDT2 in postmortem brains of Parkinson's disease and dementia with Lewy bodies patients.Neurochemistry international, , Volume: 152, 2022
Diagnosis and Treatment of Cognitive and Neuropsychiatric Symptoms in Parkinson Disease and Dementia With Lewy Bodies.Continuum (Minneapolis, Minn.), , Oct-01, Volume: 28, Issue:5, 2022
Differentiating dementia with Lewy bodies from Alzheimer's disease and Parkinson's disease dementia: an update on imaging modalities.Journal of neurology, , Volume: 269, Issue:2, 2022
Development of an α-synuclein fibril and oligomer specific tracer for diagnosis of Parkinson's disease, dementia with Lewy bodies and multiple system atrophy.Neurochemistry international, , Volume: 161, 2022
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Alpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a Parkinson's disease patient (PARK4) with SNCA triplication.FEBS open bio, , Volume: 11, Issue:2, 2021
Immunohistochemical Detection of Synuclein Pathology in Skin in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:4, 2021
Lewy pathology of the esophagus correlates with the progression of Lewy body disease: a Japanese cohort study of autopsy cases.Acta neuropathologica, , Volume: 141, Issue:1, 2021
Cerebrospinal fluid α synuclein concentrations in patients with positive AD biomarkers and extrapyramidal symptoms.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 128, Issue:6, 2021
RT-QuIC Detection of Pathological α-Synuclein in Skin Punches of Patients with Lewy Body Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:9, 2021
Microglia is associated with p-Tau aggregates in the olfactory bulb of patients with neurodegenerative diseases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 42, Issue:4, 2021
Faster disease progression in Parkinson's disease with type 2 diabetes is not associated with increased α-synuclein, tau, amyloid-β or vascular pathology.Neuropathology and applied neurobiology, , Volume: 47, Issue:7, 2021
Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies.Acta neuropathologica communications, , 08-28, Volume: 9, Issue:1, 2021
Nasal Rifampicin Improves Cognition in a Mouse Model of Dementia with Lewy Bodies by Reducing α-Synuclein Oligomers.International journal of molecular sciences, , Aug-06, Volume: 22, Issue:16, 2021
Dysfunction of RAB39B-Mediated Vesicular Trafficking in Lewy Body Diseases.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:8, 2021
Associations of Neuropsychiatric Features with Cerebrospinal Fluid Biomarkers of Amyloidogenesis and Neurodegeneration in Dementia with Lewy Bodies Compared with Alzheimer's Disease and Cognitively Healthy People.Journal of Alzheimer's disease : JAD, , Volume: 81, Issue:3, 2021
Phytochemicals as Regulators of Genes Involved in Synucleinopathies.Biomolecules, , 04-22, Volume: 11, Issue:5, 2021
Consistent skin α-synuclein positivity in REM sleep behavior disorder - A two center two-to-four-year follow-up study.Parkinsonism & related disorders, , Volume: 86, 2021
STochastic Optical Reconstruction Microscopy (STORM) reveals the nanoscale organization of pathological aggregates in human brain.Neuropathology and applied neurobiology, , Volume: 47, Issue:1, 2021
Alpha-Synuclein Oligomers and Neurofilament Light Chain Predict Phenoconversion of Pure Autonomic Failure.Annals of neurology, , Volume: 89, Issue:6, 2021
Molecular Factors Mediating Neural Cell Plasticity Changes in Dementia Brain Diseases.Neural plasticity, , Volume: 2021, 2021
In Vivo Diagnosis of Synucleinopathies: A Comparative Study of Skin Biopsy and RT-QuIC.Neurology, , 05-18, Volume: 96, Issue:20, 2021
Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson's disease and dementia with Lewy bodies.Acta neuropathologica communications, , 04-07, Volume: 9, Issue:1, 2021
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Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson's disease.Acta neuropathologica communications, , 03-20, Volume: 9, Issue:1, 2021
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Multiple Neurodegenerative Pathologies in an Alzheimer's Disease Patient Treated with Fornical Deep Brain Stimulation.Journal of Alzheimer's disease : JAD, , Volume: 80, Issue:4, 2021
Lewy bodies in the olfactory system and the hypothalamus.Handbook of clinical neurology, , Volume: 182, 2021
Tyrosine 136 phosphorylation of α-synuclein aggregates in the Lewy body dementia brain: involvement of serine 129 phosphorylation by casein kinase 2.Acta neuropathologica communications, , 11-12, Volume: 9, Issue:1, 2021
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Targeted de-repression of neuronal Nrf2 inhibits α-synuclein accumulation.Cell death & disease, , 02-26, Volume: 12, Issue:2, 2021
Diagnostic Value of the CSF α-Synuclein Real-Time Quaking-Induced Conversion Assay at the Prodromal MCI Stage of Dementia With Lewy Bodies.Neurology, , 08-31, Volume: 97, Issue:9, 2021
Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study.The Lancet. Neurology, , Volume: 20, Issue:3, 2021
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Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture.Nature genetics, , Volume: 53, Issue:3, 2021
α-Synuclein Heteromers in Red Blood Cells of Alzheimer's Disease and Lewy Body Dementia Patients.Journal of Alzheimer's disease : JAD, , Volume: 80, Issue:2, 2021
CSF Protein Level of Neurotransmitter Secretion, Synaptic Plasticity, and Autophagy in PD and DLB.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:11, 2021
Significant Overlap of α-Synuclein, Amyloid-β, and Phospho-Tau Pathologies in Neuropathological Diagnosis of Lewy-related Pathology: Evidence from China Human Brain Bank.Journal of Alzheimer's disease : JAD, , Volume: 80, Issue:1, 2021
Vagus Nerve and Stomach Synucleinopathy in Parkinson's Disease, Incidental Lewy Body Disease, and Normal Elderly Subjects: Evidence Against the "Body-First" Hypothesis.Journal of Parkinson's disease, , Volume: 11, Issue:4, 2021
Lewy pathology of the submandibular gland in Lewy body disease: A report of autopsy cases.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 41, Issue:6, 2021
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Human amyloid beta and α-synuclein co-expression in neurons impair behavior and recapitulate features for Lewy body dementia in Caenorhabditis elegans.Biochimica et biophysica acta. Molecular basis of disease, , 10-01, Volume: 1867, Issue:10, 2021
RT-QUiC in multiple system atrophy: the biomarker of the future? and other updates on recent autonomic research.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 31, Issue:1, 2021
Complicity of α-synuclein oligomer and calcium dyshomeostasis in selective neuronal vulnerability in Lewy body disease.Archives of pharmacal research, , Volume: 44, Issue:6, 2021
Establishment of Method for the Determination of Aggregated α-Synuclein in DLB Patient Using RT-QuIC Assay.Protein and peptide letters, , Volume: 28, Issue:1, 2021
Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer's Disease.Medicina (Kaunas, Lithuania), , Sep-10, Volume: 57, Issue:9, 2021
RT-QuIC Using C-Terminally Truncated α-Synuclein Forms Detects Differences in Seeding Propensity of Different Brain Regions from Synucleinopathies.Biomolecules, , 05-31, Volume: 11, Issue:6, 2021
Different patterns of hippocampal subfield pathology in Lewy body disease and Alzheimer's disease.Neuropathology and applied neurobiology, , Volume: 47, Issue:5, 2021
Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo.Nature communications, , 09-10, Volume: 12, Issue:1, 2021
Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model.Molecular neurodegeneration, , 09-09, Volume: 16, Issue:1, 2021
Insights into Lewy body disease from rare neurometabolic disorders.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 128, Issue:10, 2021
Seeding Propensity and Characteristics of Pathogenic αSyn Assemblies in Formalin-Fixed Human Tissue from the Enteric Nervous System, Olfactory Bulb, and Brainstem in Cases Staged for Parkinson's Disease.Cells, , 01-12, Volume: 10, Issue:1, 2021
Lewy Body Pathology: From Amyloidosis to Vesicle Trafficking.Protein and peptide letters, , Volume: 28, Issue:11, 2021
Pathologically Decreased CSF Levels of Synaptic Marker NPTX2 in DLB Are Correlated with Levels of Alpha-Synuclein and VGF.Cells, , 12-29, Volume: 10, Issue:1, 2020
The value of cerebrospinal fluid α-synuclein and the tau/α-synuclein ratio for diagnosis of neurodegenerative disorders with Lewy pathology.European journal of neurology, , Volume: 27, Issue:1, 2020
Novel antibodies detect additional α-synuclein pathology in synucleinopathies: potential development for immunotherapy.Alzheimer's research & therapy, , 11-30, Volume: 12, Issue:1, 2020
Small vessel disease pathological changes in neurodegenerative and vascular dementias concomitant with autonomic dysfunction.Brain pathology (Zurich, Switzerland), , Volume: 30, Issue:1, 2020
Impaired metabolic brain networks associated with neurotransmission systems in the α-synuclein spectrum.Parkinsonism & related disorders, , Volume: 81, 2020
CD8 T cell nigral infiltration precedes synucleinopathy in early stages of Parkinson's disease.Brain : a journal of neurology, , 12-01, Volume: 143, Issue:12, 2020
Comparison of 123I-MIBG scintigraphy and phosphorylated α-synuclein skin deposits in synucleinopathies.Parkinsonism & related disorders, , Volume: 81, 2020
Orthostatic hypotension as a core symptom in a Japanese family harboring SNCA duplication.Parkinsonism & related disorders, , Volume: 81, 2020
Neuronal activity modulates alpha-synuclein aggregation and spreading in organotypic brain slice cultures and in vivo.Acta neuropathologica, , Volume: 140, Issue:6, 2020
Systematic review of gene expression studies in people with Lewy body dementia.Acta neuropsychiatrica, , Volume: 32, Issue:6, 2020
Differential diagnostic value of total alpha-synuclein assay in the cerebrospinal fluid between Alzheimer's disease and dementia with Lewy bodies from the prodromal stage.Alzheimer's research & therapy, , 09-29, Volume: 12, Issue:1, 2020
Autonomic dysfunction is associated with neuropsychological impairment in Lewy body disease.Journal of neurology, , Volume: 267, Issue:7, 2020
How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structNeurobiology of disease, , Volume: 146, 2020
Blinded RT-QuIC Analysis of α-Synuclein Biomarker in Skin Tissue From Parkinson's Disease Patients.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:12, 2020
Associations of sleep characteristics with alpha-synuclein in cerebrospinal fluid in older adults.Annals of clinical and translational neurology, , Volume: 7, Issue:10, 2020
The Nosology of Lewy Body Disorders From Analytic-Epidemiologic and Statistical Vantage Points.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:12, 2020
Hippocampal subfield pathologic burden in Lewy body diseases vs. Alzheimer's disease.Neuropathology and applied neurobiology, , Volume: 46, Issue:7, 2020
The Leukotriene Receptor Antagonist Montelukast Reduces Alpha-Synuclein Load and Restores Memory in an Animal Model of Dementia with Lewy Bodies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 17, Issue:3, 2020
RT-QuIC-based detection of alpha-synuclein seeding activity in brains of dementia with Lewy Body patients and of a transgenic mouse model of synucleinopathy.Prion, , Volume: 14, Issue:1, 2020
[α-Synuclein as Diagnostic Biomarker].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:2, 2020
[REM Sleep Behavior Disorder and α-synucleinopathy].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:2, 2020
A novel SNCA E83Q mutation in a case of dementia with Lewy bodies and atypical frontotemporal lobar degeneration.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 40, Issue:6, 2020
Discoidin Domain Receptor 1 is a therapeutic target for neurodegenerative diseases.Human molecular genetics, , 10-10, Volume: 29, Issue:17, 2020
APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid.Science translational medicine, , 02-05, Volume: 12, Issue:529, 2020
Fabry Disease With Concomitant Lewy Body Disease.Journal of neuropathology and experimental neurology, , 04-01, Volume: 79, Issue:4, 2020
The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure.Proceedings of the National Academy of Sciences of the United States of America, , 02-18, Volume: 117, Issue:7, 2020
Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor.International journal of molecular sciences, , Jul-22, Volume: 21, Issue:15, 2020
Fine-Mapping of SNCA in Rapid Eye Movement Sleep Behavior Disorder and Overt Synucleinopathies.Annals of neurology, , Volume: 87, Issue:4, 2020
Aβ Puts the Alpha in Synuclein.Neuron, , 01-22, Volume: 105, Issue:2, 2020
Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models.Journal of neuroinflammation, , Jul-17, Volume: 17, Issue:1, 2020
NK cells clear α-synuclein and the depletion of NK cells exacerbates synuclein pathology in a mouse model of α-synucleinopathy.Proceedings of the National Academy of Sciences of the United States of America, , 01-21, Volume: 117, Issue:3, 2020
Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult.Neuron, , 03-04, Volume: 105, Issue:5, 2020
Systematic review of genetic association studies in people with Lewy body dementia.International journal of geriatric psychiatry, , Volume: 35, Issue:5, 2020
Subtypes of dementia with Lewy bodies are associated with α-synuclein and tau distribution.Neurology, , 07-14, Volume: 95, Issue:2, 2020
Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease.Neurobiology of disease, , Volume: 136, 2020
Alpha-Synuclein Oligomers and Neurofilament Light Chain in Spinal Fluid Differentiate Multiple System Atrophy from Lewy Body Synucleinopathies.Annals of neurology, , Volume: 88, Issue:3, 2020
TDP-1/TDP-43 potentiates human α-Synuclein (HASN) neurodegeneration in Caenorhabditis elegans.Biochimica et biophysica acta. Molecular basis of disease, , 10-01, Volume: 1866, Issue:10, 2020
Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology.Neuron, , 01-22, Volume: 105, Issue:2, 2020
α-Synuclein real-time quaking-induced conversion in the submandibular glands of Parkinson's disease patients.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:2, 2020
Infections or Sepsis Preceding Clinically Diagnosed α-Synucleinopathies: A Case-Control Study.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:9, 2020
Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia.Brain : a journal of neurology, , 01-01, Volume: 143, Issue:1, 2020
Anti-aggregation Effects of Phenolic Compounds on α-synuclein.Molecules (Basel, Switzerland), , May-24, Volume: 25, Issue:10, 2020
Detection and Assessment of α-Synuclein Oligomers in the Urine of Parkinson's Disease Patients.Journal of Parkinson's disease, , Volume: 10, Issue:3, 2020
Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity.Scientific reports, , 05-18, Volume: 10, Issue:1, 2020
The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson's disease, multiple system atrophy and dementia with Lewy bodies.Acta neuropathologica, , Volume: 139, Issue:6, 2020
Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies.Acta neuropathologica, , Volume: 140, Issue:1, 2020
Investigating the presence of doubly phosphorylated α-synuclein at tyrosine 125 and serine 129 in idiopathic Lewy body diseases.Brain pathology (Zurich, Switzerland), , Volume: 30, Issue:4, 2020
Analysis of Protein Conformational Strains-A Key for New Diagnostic Methods of Human Diseases.International journal of molecular sciences, , Apr-17, Volume: 21, Issue:8, 2020
Neuropathology of Lewy body disease: Clinicopathological crosstalk between typical and atypical cases.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 40, Issue:1, 2020
Erythrocytes as Biomarkers for Dementia: Analysis of Protein Content and Alpha-Synuclein.Journal of Alzheimer's disease : JAD, , 08-12, Volume: 71, Issue:2, 2019
Alzheimer's disease and other neurodegenerative dementias in comorbidity: A clinical and neuropathological overview.Clinical biochemistry, , Volume: 73, 2019
Investigating the Association Between Verbal Forgetting and Pathological Markers of Alzheimer's and Lewy Body Diseases.Journal of Alzheimer's disease : JAD, , Volume: 70, Issue:3, 2019
Alpha-synuclein structure and Parkinson's disease - lessons and emerging principles.Molecular neurodegeneration, , 07-22, Volume: 14, Issue:1, 2019
TIGAR inclusion pathology is specific for Lewy body diseases.Brain research, , 03-01, Volume: 1706, 2019
Increased Serum Levels of α-Synuclein in Patients With Major Depressive Disorder.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, , Volume: 27, Issue:3, 2019
Path mediation analysis reveals GBA impacts Lewy body disease status by increasing α-synuclein levels.Neurobiology of disease, , Volume: 121, 2019
Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders.Scientific reports, , 07-29, Volume: 9, Issue:1, 2019
Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid - method comparison and round robin study.Journal of neurochemistry, , Volume: 149, Issue:1, 2019
Precision Medicine in Rapid Eye Movement Sleep Behavior Disorder.Sleep medicine clinics, , Volume: 14, Issue:3, 2019
Late-Life Depression and Lewy Body Disease.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, , Volume: 27, Issue:3, 2019
Effects of single and combined immunotherapy approach targeting amyloid β protein and α-synuclein in a dementia with Lewy bodies-like model.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 15, Issue:9, 2019
Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders.Annals of neurology, , Volume: 85, Issue:2, 2019
Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration.Brain pathology (Zurich, Switzerland), , Volume: 29, Issue:1, 2019
Dementia with Lewy bodies - from scientific knowledge to clinical insights.Nature reviews. Neurology, , Volume: 15, Issue:2, 2019
Degeneration of dopaminergic circuitry influences depressive symptoms in Lewy body disorders.Brain pathology (Zurich, Switzerland), , Volume: 29, Issue:4, 2019
Ammon's Horn 2 (CA2) of the Hippocampus: A Long-Known Region with a New Potential Role in Neurodegeneration.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, , Volume: 25, Issue:2, 2019
Differential insular cortex subregional vulnerability to α-synuclein pathology in Parkinson's disease and dementia with Lewy bodies.Neuropathology and applied neurobiology, , Volume: 45, Issue:3, 2019
Extreme sleep pattern in Lewy body dementia: a hypothalamic matter?BMJ case reports, , Mar-09, Volume: 12, Issue:3, 2019
The center of olfactory bulb-seeded α-synucleinopathy is the limbic system and the ensuing pathology is higher in male than in female mice.Brain pathology (Zurich, Switzerland), , Volume: 29, Issue:6, 2019
Clinical and neuropathological differences between Parkinson's disease, Parkinson's disease dementia and dementia with Lewy bodies - current issues and future directions.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
[Differential diagnosis of RBD symptomatology (idiopathic RBD or RBD mimics)].Rinsho shinkeigaku = Clinical neurology, , Apr-25, Volume: 59, Issue:4, 2019
[A case of severe obstructive sleep apnea mimicking REM sleep behavior disorder].Rinsho shinkeigaku = Clinical neurology, , Apr-25, Volume: 59, Issue:4, 2019
Parafoveal thinning of inner retina is associated with visual dysfunction in Lewy body diseases.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:9, 2019
Expression of α-synuclein is regulated in a neuronal cell type-dependent manner.Anatomical science international, , Volume: 94, Issue:1, 2019
Differential diagnosis between Alzheimer's disease and other dementias: Role of cerebrospinal fluid biomarkers.Clinical biochemistry, , Volume: 72, 2019
α-Synuclein and astrocytes: tracing the pathways from homeostasis to neurodegeneration in Lewy body disease.Acta neuropathologica, , Volume: 138, Issue:1, 2019
Phosphorylated NUB1 distinguishes α-synuclein in Lewy bodies from that in glial cytoplasmic inclusions in multiple system atrophy.Brain pathology (Zurich, Switzerland), , Volume: 29, Issue:6, 2019
Associations Between APOE Variants, Tau and α-Synuclein.Advances in experimental medicine and biology, , Volume: 1184, 2019
Abundance of Synaptic Vesicle-Related Proteins in Alpha-Synuclein-Containing Protein Inclusions Suggests a Targeted Formation Mechanism.Neurotoxicity research, , Volume: 35, Issue:4, 2019
The heart of PD: Lewy body diseases as neurocardiologic disorders.Brain research, , 01-01, Volume: 1702, 2019
Coexisting Lewy body disease and clinical parkinsonism in frontotemporal lobar degeneration.Neurology, , 05-21, Volume: 92, Issue:21, 2019
Neuropathological and genetic characteristics of a post-mortem series of cases with dementia with Lewy bodies clinically suspected of Creutzfeldt-Jakob's disease.Parkinsonism & related disorders, , Volume: 63, 2019
GBA1-associated parkinsonism: new insights and therapeutic opportunities.Current opinion in neurology, , Volume: 32, Issue:4, 2019
Dementia with lewy bodies: GBA1 mutations are associated with cerebrospinal fluid alpha-synuclein profile.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:7, 2019
Polysomnographic data in Dementia with Lewy Bodies: correlation with clinical symptoms and comparison with other α-synucleinopathies.Sleep medicine, , Volume: 55, 2019
Classification of GBA Variants and Their Effects in Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:10, 2019
Measurement of CSF α-synuclein improves early differential diagnosis of mild cognitive impairment due to Alzheimer's disease.Journal of neurochemistry, , Volume: 150, Issue:2, 2019
Behavioral symptomatology and psychopharmacology of Lewy body dementia.Handbook of clinical neurology, , Volume: 165, 2019
Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes.Nature neuroscience, , Volume: 22, Issue:7, 2019
α-Synuclein oligomers mediate the aberrant form of spike-induced calcium release from IPScientific reports, , 11-04, Volume: 9, Issue:1, 2019
Stabilization of α-synuclein oligomers using formaldehyde.PloS one, , Volume: 14, Issue:10, 2019
Lower nucleus accumbens α-synuclein load and D3 receptor levels in Parkinson's disease with impulsive compulsive behaviours.Brain : a journal of neurology, , 11-01, Volume: 142, Issue:11, 2019
α-Synuclein RT-QuIC assay in cerebrospinal fluid of patients with dementia with Lewy bodies.Annals of clinical and translational neurology, , Volume: 6, Issue:10, 2019
[Prion-like Propagation of Pathological α-Synuclein in Vivo].Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, , Volume: 139, Issue:7, 2019
Ultrasensitive Detection of Aggregated α-Synuclein in Glial Cells, Human Cerebrospinal Fluid, and Brain Tissue Using the RT-QuIC Assay: New High-Throughput Neuroimmune Biomarker Assay for Parkinsonian Disorders.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 14, Issue:3, 2019
Heterogeneity in α-synuclein subtypes and their expression in cortical brain tissue lysates from Lewy body diseases and Alzheimer's disease.Neuropathology and applied neurobiology, , Volume: 45, Issue:6, 2019
Simultaneous quantification of tau and α-synuclein in cerebrospinal fluid by high-resolution mass spectrometry for differentiation of Lewy Body Dementia from Alzheimer's Disease and controls.The Analyst, , Oct-22, Volume: 144, Issue:21, 2019
[Real-time Quaking-induced Conversion Analysis of Prion-like Seeding Activity of Pathological α-Synuclein].Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, , Volume: 139, Issue:7, 2019
VGF Peptides in Cerebrospinal Fluid of Patients with Dementia with Lewy Bodies.International journal of molecular sciences, , Sep-20, Volume: 20, Issue:19, 2019
Unified Staging System for Lewy Body Disorders: Clinicopathologic Correlations and Comparison to Braak Staging.Journal of neuropathology and experimental neurology, , 10-01, Volume: 78, Issue:10, 2019
Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression.Acta neuropathologica communications, , 09-02, Volume: 7, Issue:1, 2019
Seeding of protein aggregation causes cognitive impairment in rat model of cortical synucleinopathy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:11, 2019
Intriguing Mixed Pathologic Features in a Case of Dementia With Lewy Bodies.The Journal of the American Osteopathic Association, , Sep-01, Volume: 119, Issue:9, 2019
Propagation of alpha-synuclein pathology from the olfactory bulb: possible role in the pathogenesis of dementia with Lewy bodies.Cell and tissue research, , Volume: 373, Issue:1, 2018
Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype.Autophagy, , Volume: 14, Issue:1, 2018
Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 14, Issue:8, 2018
Acid ceramidase inhibition ameliorates α-synuclein accumulation upon loss of GBA1 function.Human molecular genetics, , 06-01, Volume: 27, Issue:11, 2018
Molecular changes in the absence of severe pathology in the pulvinar in dementia with Lewy bodies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:6, 2018
14-3-3 protein sigma isoform co-localizes with phosphorylated α-synuclein in Lewy bodies and Lewy neurites in patients with Lewy body disease.Neuroscience letters, , 05-01, Volume: 674, 2018
FKBP12-immunopositive inclusions in patients with α-synucleinopathies.Brain research, , 02-01, Volume: 1680, 2018
Skin α-synuclein deposits differ in clinical variants of synucleinopathy: an in vivo study.Scientific reports, , 09-24, Volume: 8, Issue:1, 2018
Interaction of amyloidogenic proteins in pancreatic β cells from subjects with synucleinopathies.Acta neuropathologica, , Volume: 135, Issue:6, 2018
Author response: A new potential biomarker for dementia with Lewy bodies: Skin nerve α-synuclein deposits.Neurology, , 03-13, Volume: 90, Issue:11, 2018
Reader response: A new potential biomarker for dementia with Lewy bodies: Skin nerve α-synuclein deposits.Neurology, , 03-13, Volume: 90, Issue:11, 2018
Diagnostic value of cerebrospinal fluid alpha-synuclein in dementia with Lewy body.Geriatrie et psychologie neuropsychiatrie du vieillissement, , Sep-01, Volume: 16, Issue:3, 2018
α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton.Neuron, , 01-03, Volume: 97, Issue:1, 2018
Ceftriaxone Treatment for Neuronal Deficits: A Histological and MEMRI Study in a Rat Model of Dementia with Lewy Bodies.Behavioural neurology, , Volume: 2018, 2018
Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson's disease and DLB.Proceedings of the National Academy of Sciences of the United States of America, , 12-18, Volume: 115, Issue:51, 2018
Implications of Metal Binding and Asparagine Deamidation for Amyloid Formation.International journal of molecular sciences, , Aug-19, Volume: 19, Issue:8, 2018
Improving the identification of dementia with Lewy bodies in the context of an Alzheimer's-type dementia.Alzheimer's research & therapy, , 03-01, Volume: 10, Issue:1, 2018
14-3-3 Proteins Reduce Cell-to-Cell Transfer and Propagation of Pathogenic α-Synuclein.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 09-19, Volume: 38, Issue:38, 2018
Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation.Molecular neurodegeneration, , 08-09, Volume: 13, Issue:1, 2018
Accumulation of beta-synuclein in cortical neurons is associated with autophagy attenuation in the brains of dementia with Lewy body patients.Brain research, , 02-15, Volume: 1681, 2018
Neuropsychiatric symptoms and α-Synuclein profile of patients with Parkinson's disease dementia, dementia with Lewy bodies and Alzheimer's disease.Journal of neurology, , Volume: 265, Issue:10, 2018
[Autonomic Dysfunction and Skin Biopsy in Dementia with Lewy Bodies].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 70, Issue:8, 2018
Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports.Journal of neuropathology and experimental neurology, , 09-01, Volume: 77, Issue:9, 2018
Genetics of Synucleinopathies.Cold Spring Harbor perspectives in medicine, , 06-01, Volume: 8, Issue:6, 2018
INDEL Length and Haplotypes in the β-Synuclein Gene: A Key to Differentiate Dementia with Lewy Bodies?Journal of Alzheimer's disease : JAD, , Volume: 65, Issue:1, 2018
Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease.Autophagy, , Volume: 14, Issue:8, 2018
A refined concept: α-synuclein dysregulation disease.Neurochemistry international, , Volume: 119, 2018
Methylation changes and aberrant expression of FGFR3 in Lewy body disease neurons.Brain research, , 10-15, Volume: 1697, 2018
Alzheimer disease biomarkers and synucleinopathy.Neurology, , 03-20, Volume: 90, Issue:12, 2018
A novel link between trafficking and Lewy body disorders.The Lancet. Neurology, , Volume: 17, Issue:7, 2018
Effects of Novel Calpain Inhibitors in Transgenic Animal Model of Parkinson's disease/dementia with Lewy bodies.Scientific reports, , 12-27, Volume: 8, Issue:1, 2018
Rapid eye movement sleep behavior disorder and the link to alpha-synucleinopathies.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, , Volume: 129, Issue:8, 2018
Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated.Brain : a journal of neurology, , 07-01, Volume: 141, Issue:7, 2018
Associations between ZnT3, tau pathology, agitation, and delusions in dementia.International journal of geriatric psychiatry, , Volume: 33, Issue:8, 2018
Relationships between lewy and tau pathologies in 375 consecutive non-Alzheimer's olfactory bulbs.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:2, 2018
α-Synuclein aggregates in labial salivary glands of idiopathic rapid eye movement sleep behavior disorder.Sleep, , 08-01, Volume: 41, Issue:8, 2018
Predicting alpha-synuclein pathology by REM sleep behavior disorder diagnosis.Parkinsonism & related disorders, , Volume: 55, 2018
α-Synuclein species as potential cerebrospinal fluid biomarkers for dementia with lewy bodies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:11, 2018
[Multi-Organ Distribution of Alpha-Synuclein Pathology in Dementia with Lewy Bodies].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 70, Issue:5, 2018
The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson's disease.Scientific reports, , 11-01, Volume: 8, Issue:1, 2018
Dexamethasone Inhibits Copper-Induced Alpha-Synuclein Aggregation by a Metallothionein-Dependent Mechanism.Neurotoxicity research, , Volume: 33, Issue:2, 2018
Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies.Nature, , Volume: 557, Issue:7706, 2018
Phosphorylated α-synuclein in the retina is a biomarker of Parkinson's disease pathology severity.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:8, 2018
The limbic and neocortical contribution of α-synuclein, tau, and amyloid β to disease duration in dementia with Lewy bodies.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 14, Issue:3, 2018
Spectrum of abnormalities of sympathetic tyrosine hydroxylase and alpha-synuclein in chronic autonomic failure.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 28, Issue:2, 2018
Lewy Body Dementia.Clinics in geriatric medicine, , Volume: 34, Issue:4, 2018
ɑ-Synuclein strains and seeding in Parkinson's disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences.Cell and tissue research, , Volume: 373, Issue:1, 2018
Regional levels of physiological α-synuclein are directly associated with Lewy body pathology.Acta neuropathologica, , Volume: 135, Issue:1, 2018
Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods.Acta neuropathologica communications, , 04-18, Volume: 6, Issue:1, 2018
Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC.Acta neuropathologica communications, , 02-09, Volume: 6, Issue:1, 2018
Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.Disease models & mechanisms, , 05-01, Volume: 10, Issue:5, 2017
Histones facilitate α-synuclein aggregation during neuronal apoptosis.Acta neuropathologica, , Volume: 133, Issue:4, 2017
Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis.The Lancet. Neurology, , Volume: 16, Issue:1, 2017
Effects of α-synuclein on axonal transport.Neurobiology of disease, , Volume: 105, 2017
Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid.JAMA neurology, , Feb-01, Volume: 74, Issue:2, 2017
Metabolic connectomics targeting brain pathology in dementia with Lewy bodies.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 37, Issue:4, 2017
Increased Transforming Growth Factor β2 in the Neocortex of Alzheimer's Disease and Dementia with Lewy Bodies is Correlated with Disease Severity and Soluble Aβ42 Load.Journal of Alzheimer's disease : JAD, , Volume: 56, Issue:1, 2017
An order in Lewy body disorders: Retrograde degeneration in hyperbranching axons as a fundamental structural template accounting for focal/multifocal Lewy body disease.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 37, Issue:2, 2017
Synucleinopathies: common features and hippocampal manifestations.Cellular and molecular life sciences : CMLS, , Volume: 74, Issue:8, 2017
DNA methylation changes at SNCA intron 1 in patients with dementia with Lewy bodies.Psychiatry and clinical neurosciences, , Volume: 71, Issue:1, 2017
A preclinical screen to evaluate pharmacotherapies for the treatment of agitation in dementia.Behavioural pharmacology, , Volume: 28, Issue:2 and 3-Sp, 2017
Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells.Human molecular genetics, , 09-15, Volume: 26, Issue:18, 2017
A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies.PloS one, , Volume: 12, Issue:9, 2017
Differential role of CSF fatty acid binding protein 3, α-synuclein, and Alzheimer's disease core biomarkers in Lewy body disorders and Alzheimer's dementia.Alzheimer's research & therapy, , Jul-28, Volume: 9, Issue:1, 2017
New Therapeutic Strategies for Lewy Body Dementias.Current neurology and neuroscience reports, , Volume: 17, Issue:9, 2017
Potential Modes of Intercellular α-Synuclein Transmission.International journal of molecular sciences, , Feb-22, Volume: 18, Issue:2, 2017
Dementia: Skin α-synuclein deposits - a new biomarker for DLB?Nature reviews. Neurology, , Volume: 13, Issue:9, 2017
A new potential biomarker for dementia with Lewy bodies: Skin nerve α-synuclein deposits.Neurology, , Jul-25, Volume: 89, Issue:4, 2017
Dementia with Lewy bodies: Diagnosis is only skin deep?Neurology, , 07-25, Volume: 89, Issue:4, 2017
Quantitative neuropathology: an update on automated methodologies and implications for large scale cohorts.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 124, Issue:6, 2017
Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology.Acta neuropathologica communications, , 06-09, Volume: 5, Issue:1, 2017
Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity.Acta neuropathologica communications, , 01-10, Volume: 5, Issue:1, 2017
Survival and Causes of Death Among People With Clinically Diagnosed Synucleinopathies With Parkinsonism: A Population-Based Study.JAMA neurology, , 07-01, Volume: 74, Issue:7, 2017
Amygdala α-Synuclein Pathology in the Population-Based Vantaa 85+ Study.Journal of Alzheimer's disease : JAD, , Volume: 58, Issue:3, 2017
Parkinson disease: Antibodies reveal age of Lewy pathology in PD.Nature reviews. Neurology, , Volume: 13, Issue:6, 2017
Fluorescence and autoradiographic evaluation of tau PET ligand PBB3 to α-synuclein pathology.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:6, 2017
Involvement of the cerebellum in Parkinson disease and dementia with Lewy bodies.Annals of neurology, , Volume: 81, Issue:6, 2017
Genetic analysis of α-synuclein 3' untranslated region and its corresponding microRNAs in relation to Parkinson's disease compared to dementia with Lewy bodies.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 13, Issue:11, 2017
Lewy Body Disorders.Neurologic clinics, , Volume: 35, Issue:2, 2017
Regional Overlap of Pathologies in Lewy Body Disorders.Journal of neuropathology and experimental neurology, , 03-01, Volume: 76, Issue:3, 2017
Changes in CD200 and intercellular adhesion molecule-1 (ICAM-1) levels in brains of Lewy body disorder cases are associated with amounts of Alzheimer's pathology not α-synuclein pathology.Neurobiology of aging, , Volume: 54, 2017
α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies.Nature medicine, , Feb-07, Volume: 23, Issue:2, 2017
The Synucleinopathies: Twenty Years On.Journal of Parkinson's disease, , Volume: 7, Issue:s1, 2017
Integrated analysis of genetic, behavioral, and biochemical data implicates neural stem cell-induced changes in immunity, neurotransmission and mitochondrial function in Dementia with Lewy Body mice.Acta neuropathologica communications, , 03-10, Volume: 5, Issue:1, 2017
Neuronal Loss and Α-Synuclein Pathology in the Superior Colliculus and Its Relationship to Visual Hallucinations in Dementia with Lewy Bodies.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, , Volume: 25, Issue:6, 2017
Lewy Bodies and the Mechanisms of Neuronal Cell Death in Parkinson's Disease and Dementia with Lewy Bodies.Brain pathology (Zurich, Switzerland), , Volume: 27, Issue:1, 2017
Hippocampal α-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and Is Consistent with Spread of Pathology.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 02-15, Volume: 37, Issue:7, 2017
Endothelin-converting enzymes degrade α-synuclein and are reduced in dementia with Lewy bodies.Journal of neurochemistry, , Volume: 141, Issue:2, 2017
Human Neural Progenitor Transplantation Rescues Behavior and Reduces α-Synuclein in a Transgenic Model of Dementia with Lewy Bodies.Stem cells translational medicine, , Volume: 6, Issue:6, 2017
Neuropathology of PARK14 is identical to idiopathic Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:5, 2017
Synaptic phosphorylated α-synuclein in dementia with Lewy bodies.Brain : a journal of neurology, , Dec-01, Volume: 140, Issue:12, 2017
LRRK2 variation and dementia with Lewy bodies.Parkinsonism & related disorders, , Volume: 31, 2016
A novel therapeutic approach for synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:12, 2016
Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril.Scientific reports, , 08-04, Volume: 6, 2016
Pure Autonomic Failure.Current neurology and neuroscience reports, , Volume: 16, Issue:8, 2016
α-Synuclein: Experimental Pathology.Cold Spring Harbor perspectives in medicine, , Sep-01, Volume: 6, Issue:9, 2016
Alpha-synuclein aggregates are excluded from calbindin-D28k-positive neurons in dementia with Lewy bodies and a unilateral rotenone mouse model.Molecular and cellular neurosciences, , Volume: 77, 2016
Neurodegeneration in tauopathies and synucleinopathies.Revue neurologique, , Volume: 172, Issue:11, 2016
α-synuclein genetic variability: A biomarker for dementia in Parkinson disease.Annals of neurology, , Volume: 79, Issue:6, 2016
Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?Journal of Parkinson's disease, , Volume: 6, Issue:1, 2016
Up-regulation of SNCA gene expression: implications to synucleinopathies.Neurogenetics, , Volume: 17, Issue:3, 2016
ɑ-Synuclein strains and the variable pathologies of synucleinopathies.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Imaging synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:6, 2016
Lewy- and Alzheimer-type pathologies in midbrain and cerebellum across the Lewy body disorders spectrum.Neuropathology and applied neurobiology, , Volume: 42, Issue:5, 2016
The role of NUB1 in α-synuclein degradation in Lewy body disease model mice.Biochemical and biophysical research communications, , Feb-12, Volume: 470, Issue:3, 2016
Synaptic failure and α-synuclein.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Prevalence of Submandibular Gland Synucleinopathy in Parkinson's Disease, Dementia with Lewy Bodies and other Lewy Body Disorders.Journal of Parkinson's disease, , Volume: 6, Issue:1, 2016
Review: The spectrum of clinical features seen with alpha synuclein pathology.Neuropathology and applied neurobiology, , Volume: 42, Issue:1, 2016
Therapeutic approaches in Parkinson's disease and related disorders.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Lewy body pathology involves the olfactory cells in Parkinson's disease and related disorders.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:1, 2016
α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.Human molecular genetics, , Mar-15, Volume: 25, Issue:6, 2016
New insights into cellular α-synuclein homeostasis in health and disease.Current opinion in neurobiology, , Volume: 36, 2016
Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology.Acta neuropathologica, , Volume: 131, Issue:3, 2016
Development of Passive Immunotherapies for Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Review: Spreading the word: precise animal models and validated methods are vital when evaluating prion-like behaviour of alpha-synuclein.Neuropathology and applied neurobiology, , Volume: 42, Issue:1, 2016
shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity.PLoS genetics, , Volume: 12, Issue:4, 2016
Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies.Brain : a journal of neurology, , Volume: 139, Issue:Pt 2, 2016
Analysis of primary visual cortex in dementia with Lewy bodies indicates GABAergic involvement associated with recurrent complex visual hallucinations.Acta neuropathologica communications, , 06-30, Volume: 4, Issue:1, 2016
Unfolded protein response is activated in Lewy body dementias.Neuropathology and applied neurobiology, , Volume: 42, Issue:4, 2016
α-Synuclein pathology in the cranial and spinal nerves in Lewy body disease.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 36, Issue:3, 2016
Microglia in dementia with Lewy bodies.Brain, behavior, and immunity, , Volume: 55, 2016
Amyloid-β suppresses AMP-activated protein kinase (AMPK) signaling and contributes to α-synuclein-induced cytotoxicity.Experimental neurology, , Volume: 275 Pt 1, 2016
Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease.Proceedings of the National Academy of Sciences of the United States of America, , 08-09, Volume: 113, Issue:32, 2016
Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.Acta neuropathologica, , Volume: 131, Issue:1, 2016
Longitudinal live imaging of retinal α-synuclein::GFP deposits in a transgenic mouse model of Parkinson's Disease/Dementia with Lewy Bodies.Scientific reports, , 07-08, Volume: 6, 2016
'Under pressure': is there a link between orthostatic hypotension and cognitive impairment in α-synucleinopathies?Journal of neurology, neurosurgery, and psychiatry, , Volume: 87, Issue:12, 2016
Subcortical matter in the α-synucleinopathies spectrum: an MRI pilot study.Journal of neurology, , Volume: 263, Issue:8, 2016
Combination therapies: The next logical Step for the treatment of synucleinopathies?Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Accumulation of phosphorylated α-synuclein in subpial and periventricular astrocytes in multiple system atrophy of long duration.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 36, Issue:2, 2016
Use of CSF α-synuclein in the differential diagnosis between Alzheimer's disease and other neurodegenerative disorders.International psychogeriatrics, , Volume: 27, Issue:9, 2015
Targeting α-synuclein oligomers by protein-fragment complementation for drug discovery in synucleinopathies.Expert opinion on therapeutic targets, , Volume: 19, Issue:5, 2015
Neuropathologically mixed Alzheimer's and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes.Acta neuropathologica, , Volume: 129, Issue:5, 2015
Multiple system atrophy: the application of genetics in understanding etiology.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 25, Issue:1, 2015
Pathological interface between oligomeric alpha-synuclein and tau in synucleinopathies.Biological psychiatry, , Nov-15, Volume: 78, Issue:10, 2015
Aneuploidy in Lewy body diseases.Neurobiology of aging, , Volume: 36, Issue:3, 2015
The brainstem pathologies of Parkinson's disease and dementia with Lewy bodies.Brain pathology (Zurich, Switzerland), , Volume: 25, Issue:2, 2015
Behavioural deficits in transgenic mice expressing human truncated (1-120 amino acid) alpha-synuclein.Experimental neurology, , Volume: 264, 2015
p62 Deficiency Enhances α-Synuclein Pathology in Mice.Brain pathology (Zurich, Switzerland), , Volume: 25, Issue:5, 2015
Function of α-synuclein and PINK1 in Lewy body dementia (Review).International journal of molecular medicine, , Volume: 35, Issue:1, 2015
Parkinson's disease and prion disease: Straining the comparison.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:13, 2015
Trehalose intake induces chaperone molecules along with autophagy in a mouse model of Lewy body disease.Biochemical and biophysical research communications, , Oct-02, Volume: 465, Issue:4, 2015
Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein.Acta neuropathologica communications, , Nov-26, Volume: 3, 2015
Cerebrospinal fluid α-synuclein and Lewy body-like symptoms in normal controls, mild cognitive impairment, and Alzheimer's disease.Journal of Alzheimer's disease : JAD, , Volume: 43, Issue:3, 2015
Transmission of Soluble and Insoluble α-Synuclein to Mice.Journal of neuropathology and experimental neurology, , Volume: 74, Issue:12, 2015
Parkinson disease: Disease-linked morphometric variants of α-synuclein.Nature reviews. Neurology, , Volume: 11, Issue:8, 2015
Untangling a role for tau in synucleinopathies.Biological psychiatry, , Nov-15, Volume: 78, Issue:10, 2015
Neuroinflammation in Lewy body dementia.Parkinsonism & related disorders, , Volume: 21, Issue:12, 2015
Neural Stem Cells Rescue Cognitive and Motor Dysfunction in a Transgenic Model of Dementia with Lewy Bodies through a BDNF-Dependent Mechanism.Stem cell reports, , Nov-10, Volume: 5, Issue:5, 2015
A cytosine-thymine (CT)-rich haplotype in intron 4 of SNCA confers risk for Lewy body pathology in Alzheimer's disease and affects SNCA expression.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 11, Issue:10, 2015
α-Synuclein strains cause distinct synucleinopathies after local and systemic administration.Nature, , Jun-18, Volume: 522, Issue:7556, 2015
Neurodegeneration: Aggregates feel the strain.Nature, , Jun-18, Volume: 522, Issue:7556, 2015
Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias.Brain pathology (Zurich, Switzerland), , Volume: 25, Issue:4, 2015
Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson's Disease-like Dementia.Cell, , Oct-08, Volume: 163, Issue:2, 2015
Cerebrospinal fluid levels of IL-6 are decreased and correlate with cognitive status in DLB patients.Alzheimer's research & therapy, , Oct-05, Volume: 7, Issue:1, 2015
Expanding the spectrum of neuronal pathology in multiple system atrophy.Brain : a journal of neurology, , Volume: 138, Issue:Pt 8, 2015
Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders.Science signaling, , May-12, Volume: 8, Issue:376, 2015
Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology.Neurobiology of disease, , Volume: 79, 2015
Distribution of α-synuclein in the spinal cord and dorsal root ganglia in an autopsy cohort of elderly persons.Acta neuropathologica communications, , Sep-15, Volume: 3, 2015
Parkinson's disease and alpha-synucleinopathies: from arising pathways to therapeutic challenge.Central nervous system agents in medicinal chemistry, , Volume: 15, Issue:2, 2015
Role for the microtubule-associated protein tau variant p.A152T in risk of α-synucleinopathies.Neurology, , Nov-10, Volume: 85, Issue:19, 2015
α-Synuclein pathology accumulates in sacral spinal visceral sensory pathways.Annals of neurology, , Volume: 78, Issue:1, 2015
Flow cytometry analysis of synaptosomes from post-mortem human brain reveals changes specific to Lewy body and Alzheimer's disease.Laboratory investigation; a journal of technical methods and pathology, , Volume: 94, Issue:10, 2014
Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA.Acta neuropathologica communications, , Mar-13, Volume: 2, 2014
Convergence of pathology in dementia with Lewy bodies and Alzheimer's disease: a role for the novel interaction of alpha-synuclein and presenilin 1 in disease.Brain : a journal of neurology, , Volume: 137, Issue:Pt 7, 2014
Phospholipase D1 regulates autophagic flux and clearance of α-synuclein aggregates.Cell death and differentiation, , Volume: 21, Issue:7, 2014
Parkinson disease: A monoclonal antibody targeting misfolded α-synuclein has therapeutic potential in Parkinson disease.Nature reviews. Neurology, , Volume: 10, Issue:8, 2014
Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneurons.PloS one, , Volume: 9, Issue:7, 2014
Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo.Brain : a journal of neurology, , Volume: 137, Issue:Pt 5, 2014
Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:10, 2014
Accumulation of α-synuclein in dementia with Lewy bodies is associated with decline in the α-synuclein-degrading enzymes kallikrein-6 and calpain-1.Acta neuropathologica communications, , Dec-05, Volume: 2, 2014
Neurogranin binds α-synuclein in the human superior temporal cortex and interaction is decreased in Parkinson's disease.Brain research, , Dec-03, Volume: 1591, 2014
Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies.Human molecular genetics, , Dec-01, Volume: 23, Issue:23, 2014
Neuropathological investigation of hypocretin expression in brains of dementia with Lewy bodies.Neuroscience letters, , May-21, Volume: 569, 2014
In vivo markers of Parkinson's disease and dementia with Lewy bodies: current value of the 5G4 α-synuclein antibody.Acta neuropathologica, , Volume: 128, Issue:6, 2014
[Alpha-Synuclein in blood and cerebrospinal fluid of patients with alpha-synucleinopathy].Rinsho byori. The Japanese journal of clinical pathology, , Volume: 62, Issue:3, 2014
Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration.Cell reports, , Jun-26, Volume: 7, Issue:6, 2014
Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson's disease.Neurobiology of aging, , Volume: 35, Issue:10, 2014
Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodies.Molecular neurodegeneration, , May-19, Volume: 9, 2014
Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:8, 2014
Immunogenicity of epitope vaccines targeting different B cell antigenic determinants of human α-synuclein: feasibility study.Neuroscience letters, , Feb-07, Volume: 560, 2014
Modeling Lewy pathology propagation in Parkinson's disease.Parkinsonism & related disorders, , Volume: 20 Suppl 1, 2014
α-Synucleinopathy phenotypes.Parkinsonism & related disorders, , Volume: 20 Suppl 1, 2014
Immunohistochemical localization of spatacsin in α-synucleinopathies.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 34, Issue:2, 2014
Increased CSF α-synuclein levels in Alzheimer's disease: correlation with tau levels.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 10, Issue:5 Suppl, 2014
Alpha-synuclein immunohistochemistry of gastrointestinal and biliary surgical specimens for diagnosis of Lewy body disease.International journal of clinical and experimental pathology, , Volume: 7, Issue:4, 2014
Extracellular α--synuclein-a novel and crucial factor in Lewy body diseases.Nature reviews. Neurology, , Volume: 10, Issue:2, 2014
Immunotherapy targeting α-synuclein, with relevance for future treatment of Parkinson's disease and other Lewy body disorders.Immunotherapy, , Volume: 6, Issue:2, 2014
Comment: Braak staging in clinical practice?Neurology, , Mar-11, Volume: 82, Issue:10, 2014
Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread.Neurobiology of disease, , Volume: 69, 2014
Degeneration of brainstem respiratory neurons in dementia with Lewy bodies.Sleep, , Feb-01, Volume: 37, Issue:2, 2014
Calcineurin determines toxic versus beneficial responses to α-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , Aug-26, Volume: 111, Issue:34, 2014
Analysis of Parkinson's disease brain-derived DNA for alpha-synuclein coding somatic mutations.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:8, 2014
Reduced vascular endothelial growth factor and capillary density in the occipital cortex in dementia with Lewy bodies.Brain pathology (Zurich, Switzerland), , Volume: 24, Issue:4, 2014
Next-generation active immunization approach for synucleinopathies: implications for Parkinson's disease clinical trials.Acta neuropathologica, , Volume: 127, Issue:6, 2014
Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson's disease patients.Acta neuropathologica communications, , Aug-07, Volume: 2, 2014
Parkinsonism, dementia and glucocerebrosidase mutations.Journal of neurology, , Volume: 260, Issue:5, 2013
Glucocerebrosidase, a new player changing the old rules in Lewy body diseases.Biological chemistry, , Volume: 394, Issue:7, 2013
The impact of pathogenic mitochondrial DNA mutations on substantia nigra neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jun-26, Volume: 33, Issue:26, 2013
CSF levels of the neuronal injury biomarker visinin-like protein-1 in Alzheimer's disease and dementia with Lewy bodies.Journal of neurochemistry, , Volume: 127, Issue:5, 2013
Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia.Nature communications, , Volume: 4, 2013
Prion-like spreading of pathological α-synuclein in brain.Brain : a journal of neurology, , Volume: 136, Issue:Pt 4, 2013
Altered serum IgG levels to α-synuclein in dementia with Lewy bodies and Alzheimer's disease.PloS one, , Volume: 8, Issue:5, 2013
The Lewy body in Parkinson's disease and related neurodegenerative disorders.Molecular neurobiology, , Volume: 47, Issue:2, 2013
Neuropathologic analysis of Lewy-related α-synucleinopathy in olfactory mucosa.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 33, Issue:1, 2013
MAPT H1 haplotype is associated with enhanced α-synuclein deposition in dementia with Lewy bodies.Neurobiology of aging, , Volume: 34, Issue:3, 2013
[Hyperbranching axons template α-synuclein deposits and non-localizing clinical manifestations of Parkinson disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 65, Issue:12, 2013
The potential prognostic role of cardiovascular autonomic failure in α-synucleinopathies.European journal of neurology, , Volume: 20, Issue:2, 2013
Alpha-synuclein aggregates in epicardial fat tissue in living subjects without parkinsonism.Parkinsonism & related disorders, , Volume: 19, Issue:1, 2013
α-Synuclein posttranslational modification and alternative splicing as a trigger for neurodegeneration.Molecular neurobiology, , Volume: 47, Issue:2, 2013
[Α-synuclein as a biomarker for early diagnosis of Parkinsonism].Rinsho shinkeigaku = Clinical neurology, , Volume: 53, Issue:11, 2013
The diagnostic value of CSF α-synuclein in the differential diagnosis of dementia with Lewy bodies vs. normal subjects and patients with Alzheimer's disease.PloS one, , Volume: 8, Issue:11, 2013
Personalized medicine strategies for managing patients with parkinsonism and cognitive deficits.Metabolism: clinical and experimental, , Volume: 62 Suppl 1, 2013
Limelight on alpha-synuclein: pathological and mechanistic implications in neurodegeneration.Journal of Parkinson's disease, , Volume: 3, Issue:4, 2013
Dysfunction of the locus coeruleus-norepinephrine system and related circuitry in Parkinson's disease-related dementia.Journal of neurology, neurosurgery, and psychiatry, , Volume: 84, Issue:7, 2013
100 years of Lewy pathology.Nature reviews. Neurology, , Volume: 9, Issue:1, 2013
ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies.Acta neuropathologica communications, , May-09, Volume: 1, 2013
Changes in properties of serine 129 phosphorylated α-synuclein with progression of Lewy-type histopathology in human brains.Experimental neurology, , Volume: 240, 2013
Low CSF levels of both α-synuclein and the α-synuclein cleaving enzyme neurosin in patients with synucleinopathy.PloS one, , Volume: 8, Issue:1, 2013
Axonopathy in an α-synuclein transgenic model of Lewy body disease is associated with extensive accumulation of C-terminal-truncated α-synuclein.The American journal of pathology, , Volume: 182, Issue:3, 2013
Confluence of α-synuclein, tau, and β-amyloid pathologies in dementia with Lewy bodies.Journal of neuropathology and experimental neurology, , Volume: 72, Issue:12, 2013
SMG1 identified as a regulator of Parkinson's disease-associated alpha-synuclein through siRNA screening.PloS one, , Volume: 8, Issue:10, 2013
Submandibular gland biopsy for the diagnosis of Parkinson disease.Journal of neuropathology and experimental neurology, , Volume: 72, Issue:2, 2013
Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α-synuclein transgenic mice with the disease-causing A30P mutation.Journal of neurochemistry, , Volume: 126, Issue:1, 2013
Lewy body pathology in a patient with a homozygous parkin deletion.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:3, 2013
MRI and pathology of REM sleep behavior disorder in dementia with Lewy bodies.Neurology, , Nov-05, Volume: 81, Issue:19, 2013
Lentivirus mediated delivery of neurosin promotes clearance of wild-type α-synuclein and reduces the pathology in an α-synuclein model of LBD.Molecular therapy : the journal of the American Society of Gene Therapy, , Volume: 21, Issue:1, 2013
Pantothenate kinase-associated neurodegeneration is not a synucleinopathy.Neuropathology and applied neurobiology, , Volume: 39, Issue:2, 2013
Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study.The Lancet. Neurology, , Volume: 12, Issue:5, 2013
The diagnostic utility of cerebrospinal fluid alpha-synuclein analysis in dementia with Lewy bodies - a systematic review and meta-analysis.Parkinsonism & related disorders, , Volume: 19, Issue:10, 2013
Phosphorylated α-synuclein immunoreactivity in the posterior pituitary lobe.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 32, Issue:4, 2012
Neuropathology of sporadic Parkinson's disease: evaluation and changes of concepts.Movement disorders : official journal of the Movement Disorder Society, , Volume: 27, Issue:1, 2012
α-synuclein phosphorylation and truncation are normal events in the adult human brain.Neuroscience, , Jan-03, Volume: 200, 2012
Neuropathological investigation of the hypometabolic regions on positron emission tomography with [18F] fluorodeoxyglucose in patients with dementia with Lewy bodies.Journal of the neurological sciences, , Mar-15, Volume: 314, Issue:1-2, 2012
Post mortem cerebrospinal fluid α-synuclein levels are raised in multiple system atrophy and distinguish this from the other α-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies.Neurobiology of disease, , Volume: 45, Issue:1, 2012
Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 22, Issue:1, 2012
[Cerebrospinal fluid and plasma biomarkers for dementia with lewy bodies].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 64, Issue:5, 2012
[An 87-year-old women with the clinical diagnosis of dementia with Lewy bodies without α-synuclein deposition].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 64, Issue:5, 2012
Proteasome inhibition leads to early loss of synaptic proteins in neuronal culture.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 119, Issue:12, 2012
The genetics of dementia with Lewy bodies: what are we missing?Archives of neurology, , Volume: 69, Issue:9, 2012
Methamphetamine binds to α-synuclein and causes a conformational change which can be detected by nanopore analysis.FEBS letters, , Sep-21, Volume: 586, Issue:19, 2012
Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research.PloS one, , Volume: 7, Issue:7, 2012
Spinal cord lesions in sporadic Parkinson's disease.Acta neuropathologica, , Volume: 124, Issue:5, 2012
Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H β-synuclein.Molecular brain, , Sep-26, Volume: 5, 2012
Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Sep-26, Volume: 32, Issue:39, 2012
GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology.Neurology, , Nov-06, Volume: 79, Issue:19, 2012
Possible alterations in β-Synuclein, the non-amyloidogenic homologue of α-Synuclein, during progression of sporadic α-synucleinopathies.International journal of molecular sciences, , Volume: 13, Issue:9, 2012
Role of α-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrus.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-21, Volume: 32, Issue:47, 2012
α-Synuclein mRNA and soluble α-synuclein protein levels in post-mortem brain from patients with Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease.Brain research, , Jun-12, Volume: 1459, 2012
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice.The Journal of experimental medicine, , May-07, Volume: 209, Issue:5, 2012
Neuropathological analysis of brainstem cholinergic and catecholaminergic nuclei in relation to rapid eye movement (REM) sleep behaviour disorder.Neuropathology and applied neurobiology, , Volume: 38, Issue:2, 2012
Critical role of truncated α-synuclein and aggregates in Parkinson's disease and incidental Lewy body disease.Brain pathology (Zurich, Switzerland), , Volume: 22, Issue:6, 2012
Relationship between mitochondria and α-synuclein: a study of single substantia nigra neurons.Archives of neurology, , Volume: 69, Issue:3, 2012
Biochemical increase in phosphorylated alpha-synuclein precedes histopathology of Lewy-type synucleinopathies.Brain pathology (Zurich, Switzerland), , Volume: 22, Issue:6, 2012
Pathologic evaluation of the supraoptic and paraventricular nuclei in dementia.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, , Volume: 39, Issue:2, 2012
Lewy-like aggregation of α-synuclein reduces protein phosphatase 2A activity in vitro and in vivo.Neuroscience, , Apr-05, Volume: 207, 2012
An evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology.Journal of neurology, neurosurgery, and psychiatry, , Volume: 83, Issue:4, 2012
Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation.The FEBS journal, , Volume: 279, Issue:6, 2012
Lewy body-related α-synucleinopathy in the spinal cord of cases with incidental Lewy body disease.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 32, Issue:1, 2012
Altered CSF orexin and α-synuclein levels in dementia patients.Journal of Alzheimer's disease : JAD, , Volume: 29, Issue:1, 2012
Synucleinopathies from bench to bedside.Parkinsonism & related disorders, , Volume: 18 Suppl 1, 2012
[Role of genetics in the etiology of synucleinopathies].Revista espanola de geriatria y gerontologia, , Volume: 46 Suppl 1, 2011
[Pathologic substrate of synucleinopathies. Introduction].Revista espanola de geriatria y gerontologia, , Volume: 46 Suppl 1, 2011
Neurogenic marker abnormalities in the hippocampus in dementia with Lewy bodies.Hippocampus, , Volume: 21, Issue:10, 2011
Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?Brain : a journal of neurology, , Volume: 134, Issue:Pt 5, 2011
α-Synuclein fate is determined by USP9X-regulated monoubiquitination.Proceedings of the National Academy of Sciences of the United States of America, , Nov-15, Volume: 108, Issue:46, 2011
Prevalence and pathology of dementia with Lewy bodies in the oldest old: a comparison with other dementing disorders.Dementia and geriatric cognitive disorders, , Volume: 31, Issue:4, 2011
Next-generation sequencing reveals regional differences of the α-synuclein methylation state independent of Lewy body disease.Neuromolecular medicine, , Volume: 13, Issue:4, 2011
Pathological roles of α-synuclein in neurological disorders.The Lancet. Neurology, , Volume: 10, Issue:11, 2011
Synphilin-1-binding protein NUB1 is colocalized with nonfibrillar, proteinase K-resistant α-synuclein in presynapses in Lewy body disease.Journal of neuropathology and experimental neurology, , Volume: 70, Issue:10, 2011
Autoantibodies against amyloid and glial-derived antigens are increased in serum and cerebrospinal fluid of Lewy body-associated dementias.Journal of Alzheimer's disease : JAD, , Volume: 26, Issue:1, 2011
CD3 in Lewy pathology: does the abnormal recall of neurodevelopmental processes underlie Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 118, Issue:1, 2011
New insights into atypical parkinsonism.Current opinion in neurology, , Volume: 24, Issue:4, 2011
Incidental Lewy body disease: do some cases represent a preclinical stage of dementia with Lewy bodies?Neurobiology of aging, , Volume: 32, Issue:5, 2011
Decreased α-synuclein serum levels in patients with Lewy body dementia compared to Alzheimer's disease patients and control subjects.Dementia and geriatric cognitive disorders, , Volume: 31, Issue:6, 2011
α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jul-06, Volume: 31, Issue:27, 2011
Neuropathology underlying clinical variability in patients with synucleinopathies.Acta neuropathologica, , Volume: 122, Issue:2, 2011
Parkinson's disease with dementia, lewy-body disorders and alpha-synuclein: recent advances and a case report.Acta neurologica Taiwanica, , Volume: 20, Issue:1, 2011
Alpha-synuclein is a cellular ferrireductase.PloS one, , Jan-10, Volume: 6, Issue:1, 2011
[Lewy bodies and Lewy neurites].Nihon rinsho. Japanese journal of clinical medicine, , Volume: 69 Suppl 8, 2011
Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease.PloS one, , Apr-29, Volume: 6, Issue:4, 2011
Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing.Annals of neurology, , Volume: 69, Issue:6, 2011
Striatal β-amyloid in dementia with Lewy bodies but not Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 118, Issue:5, 2011
Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases.The Journal of biological chemistry, , Mar-18, Volume: 286, Issue:11, 2011
Familial Parkinson disease mutations influence α-synuclein assembly.Neurobiology of disease, , Volume: 43, Issue:3, 2011
CSF amyloid-β peptides in neuropathologically diagnosed dementia with Lewy bodies and Alzheimer's disease.Journal of Alzheimer's disease : JAD, , Volume: 24, Issue:2, 2011
Identification of novel α-synuclein isoforms in human brain tissue by using an online nanoLC-ESI-FTICR-MS method.Neurochemical research, , Volume: 36, Issue:11, 2011
Partial loss of parvalbumin-containing hippocampal interneurons in dementia with Lewy bodies.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 31, Issue:1, 2011
Proteasome inhibition induces α-synuclein SUMOylation and aggregate formation.Journal of the neurological sciences, , Aug-15, Volume: 307, Issue:1-2, 2011
α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study.The Lancet. Neurology, , Volume: 10, Issue:3, 2011
REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century.Neurology, , Aug-10, Volume: 75, Issue:6, 2010
Effect of topographical distribution of α-synuclein pathology on TDP-43 accumulation in Lewy body disease.Acta neuropathologica, , Volume: 120, Issue:6, 2010
Neuroimaging for Lewy body disease: is the in vivo molecular imaging of α-synuclein neuropathology required and feasible?Brain research reviews, , Oct-05, Volume: 65, Issue:1, 2010
Association of alpha-, beta-, and gamma-Synuclein with diffuse lewy body disease.Archives of neurology, , Volume: 67, Issue:8, 2010
Brain stem pathology in Parkinson's disease: an evaluation of the Braak staging model.Movement disorders : official journal of the Movement Disorder Society, , Nov-15, Volume: 25, Issue:15, 2010
Glucocerebrosidase is present in α-synuclein inclusions in Lewy body disorders.Acta neuropathologica, , Volume: 120, Issue:5, 2010
Are synucleinopathies prion-like disorders?The Lancet. Neurology, , Volume: 9, Issue:11, 2010
CSF α-synuclein does not discriminate dementia with Lewy bodies from Alzheimer's disease.Journal of Alzheimer's disease : JAD, , Volume: 22, Issue:1, 2010
Neuropathology of dementia with Lewy bodies in advanced age: a comparison with Alzheimer disease.Neuroscience letters, , Nov-26, Volume: 485, Issue:3, 2010
Distribution of cerebral amyloid deposition and its relevance to clinical phenotype in Lewy body dementia.Neuroscience letters, , Dec-03, Volume: 486, Issue:1, 2010
Amyloid imaging of Lewy body-associated disorders.Movement disorders : official journal of the Movement Disorder Society, , Nov-15, Volume: 25, Issue:15, 2010
Abnormal neurites containing C-terminally truncated alpha-synuclein are present in Alzheimer's disease without conventional Lewy body pathology.The American journal of pathology, , Volume: 177, Issue:6, 2010
Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity.PloS one, , Nov-16, Volume: 5, Issue:11, 2010
alpha-Synuclein antibodies recognize a protein present at lower levels in the CSF of patients with dementia with Lewy bodies.International psychogeriatrics, , Volume: 22, Issue:2, 2010
Lovastatin ameliorates alpha-synuclein accumulation and oxidation in transgenic mouse models of alpha-synucleinopathies.Experimental neurology, , Volume: 221, Issue:2, 2010
TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in the brain of Parkinson's disease and dementia with Lewy bodies.Neurobiology of disease, , Volume: 38, Issue:2, 2010
Pure autonomic failure: a restricted Lewy body synucleinopathy or early Parkinson disease?Neurology, , Feb-16, Volume: 74, Issue:7, 2010
Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy.PloS one, , Feb-19, Volume: 5, Issue:2, 2010
Evidence in favor of Braak staging of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 25 Suppl 1, 2010
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-03, Volume: 30, Issue:9, 2010
Distinct region-specific alpha-synuclein oligomers in A53T transgenic mice: implications for neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-03, Volume: 30, Issue:9, 2010
Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease.Acta neuropathologica, , Volume: 119, Issue:6, 2010
Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders.Acta neuropathologica, , Volume: 119, Issue:6, 2010
Dementia with Lewy bodies associated with ataxia, myoclonus, and cortical blindness.Movement disorders : official journal of the Movement Disorder Society, , Jul-15, Volume: 25, Issue:9, 2010
Biomarkers: Parkinson disease with dementia and dementia with Lewy bodies.Parkinsonism & related disorders, , Volume: 16, Issue:5, 2010
Proteinase K-resistant alpha-synuclein is deposited in presynapses in human Lewy body disease and A53T alpha-synuclein transgenic mice.Acta neuropathologica, , Volume: 120, Issue:2, 2010
A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death.Neurobiology of aging, , Volume: 31, Issue:1, 2010
CSF synuclein: adding to the biomarker footprint of dementia with Lewy bodies.Journal of neurology, neurosurgery, and psychiatry, , Volume: 81, Issue:6, 2010
Differential levels of alpha-synuclein, beta-amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer's disease.Journal of neurology, neurosurgery, and psychiatry, , Volume: 81, Issue:6, 2010
Caspase-cleaved transactivation response DNA-binding protein 43 in Parkinson's disease and dementia with Lewy bodies.Neuro-degenerative diseases, , Volume: 7, Issue:4, 2010
The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia.Acta neuropathologica, , Volume: 120, Issue:2, 2010
Neuroscience and heart-brain medicine: the year in review.Cleveland Clinic journal of medicine, , Volume: 77 Suppl 3, 2010
A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders.Biochimica et biophysica acta, , Volume: 1792, Issue:7, 2009
Intralaminar nuclei of the thalamus in Lewy body diseases.Brain research bulletin, , Feb-16, Volume: 78, Issue:2-3, 2009
Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders.Acta neuropathologica, , Volume: 117, Issue:2, 2009
Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders.Acta neuropathologica, , Volume: 117, Issue:2, 2009
Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss?Neuroscience letters, , Feb-06, Volume: 450, Issue:3, 2009
CSF alpha-synuclein levels in dementia with Lewy bodies and Alzheimer's disease.Brain research, , Jan-28, Volume: 1251, 2009
Early-onset familial lewy body dementia with extensive tauopathy: a clinical, genetic, and neuropathological study.Journal of neuropathology and experimental neurology, , Volume: 68, Issue:1, 2009
Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies.Brain : a journal of neurology, , Volume: 132, Issue:Pt 4, 2009
Parkinson's disease dementia and dementia with Lewy bodies: different aspects of one entity.International psychogeriatrics, , Volume: 21, Issue:2, 2009
Nuclear and neuritic distribution of serine-129 phosphorylated alpha-synuclein in transgenic mice.Neuroscience, , Jun-02, Volume: 160, Issue:4, 2009
Anti-aggregation and fibril-destabilizing effects of sex hormones on alpha-synuclein fibrils in vitro.Experimental neurology, , Volume: 217, Issue:2, 2009
Staging/typing of Lewy body related alpha-synuclein pathology: a study of the BrainNet Europe Consortium.Acta neuropathologica, , Volume: 117, Issue:6, 2009
Regional differences in the severity of Lewy body pathology across the olfactory cortex.Neuroscience letters, , Apr-03, Volume: 453, Issue:2, 2009
Heavy alcohol consumption and neuropathological lesions: a post-mortem human study.Journal of neuroscience research, , Volume: 87, Issue:12, 2009
Molecular pathology of Lewy body diseases.International journal of molecular sciences, , Volume: 10, Issue:3, 2009
Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction.Acta neuropathologica, , Volume: 117, Issue:6, 2009
The genetics of Parkinson's syndromes: a critical review.Current opinion in genetics & development, , Volume: 19, Issue:3, 2009
The association between mutations in the lysosomal protein glucocerebrosidase and parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Aug-15, Volume: 24, Issue:11, 2009
Intrinsic disorder in proteins associated with neurodegenerative diseases.Frontiers in bioscience (Landmark edition), , 06-01, Volume: 14, Issue:14, 2009
Dorsal motor nucleus of vagus protein aggregates in Lewy body disease with autonomic dysfunction.Brain research, , Aug-25, Volume: 1286, 2009
Clinical correlates of pathology in the claustrum in Parkinson's disease and dementia with Lewy bodies.Neuroscience letters, , Sep-11, Volume: 461, Issue:1, 2009
Leucine-rich repeat kinase 2 expression leads to aggresome formation that is not associated with alpha-synuclein inclusions.Journal of neuropathology and experimental neurology, , Volume: 68, Issue:7, 2009
In vitro characterisation of BF227 binding to alpha-synuclein/Lewy bodies.European journal of pharmacology, , Sep-01, Volume: 617, Issue:1-3, 2009
Dopamine cell loss in the periaqueductal gray in multiple system atrophy and Lewy body dementia.Neurology, , Jul-14, Volume: 73, Issue:2, 2009
Neuropathologic findings of dementia with lewy bodies (DLB) in a population-based Vantaa 85+ study.Journal of Alzheimer's disease : JAD, , Volume: 18, Issue:3, 2009
Formation and development of Lewy pathology: a critical update.Journal of neurology, , Volume: 256 Suppl 3, 2009
Biochemical and pathological correlates of cognitive and behavioural change in DLB/PDD.Journal of neurology, , Volume: 256 Suppl 3, 2009
Neurotoxic conversion of beta-synuclein: a novel approach to generate a transgenic mouse model of synucleinopathies?Journal of neurology, , Volume: 256 Suppl 3, 2009
Incidental Lewy body disease restricted to the heart and stellate ganglia.Movement disorders : official journal of the Movement Disorder Society, , Nov-15, Volume: 24, Issue:15, 2009
Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Oct-28, Volume: 29, Issue:43, 2009
Lrrk2 interaction with alpha-synuclein in diffuse Lewy body disease.Biochemical and biophysical research communications, , Dec-25, Volume: 390, Issue:4, 2009
Creutzfeldt-jakob, Parkinson, lewy body dementia and Alzheimer diseases: from diagnosis to therapy.Central nervous system agents in medicinal chemistry, , Volume: 9, Issue:1, 2009
Lewy body variant of Alzheimer's disease: selective neocortical loss of t-SNARE proteins and loss of MAP2 and alpha-synuclein in medial temporal lobe.TheScientificWorldJournal, , Dec-16, Volume: 9, 2009
Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases.PloS one, , Sep-04, Volume: 3, Issue:9, 2008
[Molecular neuropathology of Non-Alzheimer dementia].Der Pathologe, , Volume: 29, Issue:6, 2008
Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:10, 2008
The therapeutical potential of alpha-synuclein antiaggregatory agents for dementia with Lewy bodies.Current medicinal chemistry, , Volume: 15, Issue:26, 2008
Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease.The FEBS journal, , Volume: 275, Issue:23, 2008
[Clinical and pathological study on early diagnosis of Parkinson's disease and dementia with Lewy bodies].Rinsho shinkeigaku = Clinical neurology, , Volume: 48, Issue:11, 2008
Early alpha-synuclein lipoxidation in neocortex in Lewy body diseases.Neurobiology of aging, , Volume: 29, Issue:3, 2008
Alpha- and gamma-synuclein proteins are present in cerebrospinal fluid and are increased in aged subjects with neurodegenerative and vascular changes.Dementia and geriatric cognitive disorders, , Volume: 26, Issue:1, 2008
Identification and characterization of a new alpha-synuclein isoform and its role in Lewy body diseases.Neurogenetics, , Volume: 9, Issue:1, 2008
Validation of the neuropathologic criteria of the third consortium for dementia with Lewy bodies for prospectively diagnosed cases.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:7, 2008
Commentary to "Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease".Neurochemical research, , Volume: 33, Issue:6, 2008
Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease.Brain : a journal of neurology, , Volume: 131, Issue:Pt 3, 2008
Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies.Experimental neurology, , Volume: 210, Issue:2, 2008
Early discriminatory diagnosis of dementia with Lewy bodies. The emerging role of CSF and imaging biomarkers.Dementia and geriatric cognitive disorders, , Volume: 25, Issue:3, 2008
Transgenic mice overexpressing tyrosine-to-cysteine mutant human alpha-synuclein: a progressive neurodegenerative model of diffuse Lewy body disease.The Journal of biological chemistry, , Apr-11, Volume: 283, Issue:15, 2008
A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides.Nature neuroscience, , Volume: 11, Issue:3, 2008
Differential expression of alpha-synuclein, parkin, and synphilin-1 isoforms in Lewy body disease.Neurogenetics, , Volume: 9, Issue:3, 2008
Selective detection, quantification, and subcellular location of alpha-synuclein aggregates with a protein aggregate filtration assay.BioTechniques, , Volume: 44, Issue:3, 2008
Patterns and stages of alpha-synucleinopathy: Relevance in a population-based cohort.Neurology, , Mar-25, Volume: 70, Issue:13, 2008
[Clinical and pathological study on early diagnosis of Parkinson's disease and dementia with Lewy bodies].Rinsho shinkeigaku = Clinical neurology, , Volume: 48, Issue:1, 2008
Proteasomal abnormalities in cortical Lewy body disease and the impact of proteasomal inhibition within cortical and cholinergic systems.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 115, Issue:6, 2008
An atypical autopsy case of Lewy body disease with clinically diagnosed major depression: a clinical, radiological and pathological study.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 28, Issue:6, 2008
Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementia.Archives of neurology, , Volume: 65, Issue:4, 2008
Striatal beta-amyloid deposition in Parkinson disease with dementia.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:5, 2008
Recent advances in the genetics of dementia with lewy bodies.Current neurology and neuroscience reports, , Volume: 8, Issue:3, 2008
Evaluation of alpha-synuclein immunohistochemical methods used by invited experts.Acta neuropathologica, , Volume: 116, Issue:3, 2008
Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease.Sleep medicine, , Volume: 8, Issue:1, 2007
Vitamin A potently destabilizes preformed alpha-synuclein fibrils in vitro: implications for Lewy body diseases.Neurobiology of disease, , Volume: 25, Issue:2, 2007
Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated alpha-synuclein.Journal of neuroinflammation, , Jan-04, Volume: 4, 2007
PINK1, a gene product of PARK6, accumulates in alpha-synucleinopathy brains.Journal of neurology, neurosurgery, and psychiatry, , Volume: 78, Issue:6, 2007
Synucleinopathy with features of both multiple system atrophy and dementia with Lewy bodies.Neuropathology and applied neurobiology, , Volume: 33, Issue:1, 2007
Correlation in Lewy pathology between the claustrum and visual areas in brains of dementia with Lewy bodies.Neuroscience letters, , Mar-30, Volume: 415, Issue:3, 2007
Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-07, Volume: 27, Issue:6, 2007
[Animal models of neurodegenerative diseases].Medecine sciences : M/S, , Volume: 23, Issue:2, 2007
Lewy body variant of Alzheimer's disease or cerebral type lewy body disease? Two autopsy cases of presenile onset with minimal involvement of the brainstem.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 27, Issue:1, 2007
Anti-fibrillogenic and fibril-destabilizing activity of nicotine in vitro: implications for the prevention and therapeutics of Lewy body diseases.Experimental neurology, , Volume: 205, Issue:2, 2007
Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation.The American journal of pathology, , Volume: 170, Issue:5, 2007
Analysis of the adrenal gland is useful for evaluating pathology of the peripheral autonomic nervous system in lewy body disease.Journal of neuropathology and experimental neurology, , Volume: 66, Issue:5, 2007
Do alpha-synuclein aggregates in autonomic plexuses predate Lewy body disorders?: a cohort study.Neurology, , Jun-05, Volume: 68, Issue:23, 2007
Alpha-synuclein pathology in the olfactory pathways of dementia patients.Journal of anatomy, , Volume: 211, Issue:1, 2007
Classical Parkinson disease versus Parkinson complex--reflections against staging and in favour of heterogeneity.European journal of neurology, , Volume: 14, Issue:7, 2007
Rostral raphe involvement in Lewy body dementia and multiple system atrophy.Acta neuropathologica, , Volume: 114, Issue:3, 2007
In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution.Neurology, , Jul-24, Volume: 69, Issue:4, 2007
Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases.Acta neuropathologica, , Volume: 114, Issue:3, 2007
An investigation into the lipid-binding properties of alpha-, beta- and gamma-synucleins in human brain and cerebrospinal fluid.Brain research, , Sep-19, Volume: 1170, 2007
A 75-year-old man with cognitive impairment and gait changes.Neurology, , Sep-11, Volume: 69, Issue:11, 2007
Transgenic animal models of neurodegenerative diseases and their application to treatment development.Advanced drug delivery reviews, , Sep-30, Volume: 59, Issue:11, 2007
In vitro characterization of Pittsburgh compound-B binding to Lewy bodies.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Sep-26, Volume: 27, Issue:39, 2007
Concurrence of TDP-43, tau and alpha-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies.Brain research, , Dec-12, Volume: 1184, 2007
Phosphorylated Smad 2/3 colocalizes with phospho-tau inclusions in Pick disease, progressive supranuclear palsy, and corticobasal degeneration but not with alpha-synuclein inclusions in multiple system atrophy or dementia with Lewy bodies.Journal of neuropathology and experimental neurology, , Volume: 66, Issue:11, 2007
Pathological biochemistry of alpha-synucleinopathy.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 27, Issue:5, 2007
Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-28, Volume: 27, Issue:48, 2007
Neuropathology of Parkinson's disease dementia and dementia with Lewy bodies with reference to striatal pathology.Parkinsonism & related disorders, , Volume: 13 Suppl 3, 2007
Cerebrospinal fluid of Alzheimer's disease and dementia with Lewy bodies patients enhances alpha-synuclein fibril formation in vitro.Experimental neurology, , Volume: 203, Issue:2, 2007
Dementia with Lewy bodies in an elderly Greek male due to alpha-synuclein gene mutation.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, , Volume: 13, Issue:9, 2006
Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation.Biochemical and biophysical research communications, , Dec-22, Volume: 351, Issue:3, 2006
Cortical Lewy body disease and Parkinson's disease dementia.Current opinion in neurology, , Volume: 19, Issue:6, 2006
Identification of G-protein coupled receptor kinase 2 in paired helical filaments and neurofibrillary tangles.Journal of neuropathology and experimental neurology, , Volume: 65, Issue:12, 2006
Differences in neuropathologic characteristics across the Lewy body dementia spectrum.Neurology, , Dec-12, Volume: 67, Issue:11, 2006
Positron emission tomography changes in PARK1 mutation.Movement disorders : official journal of the Movement Disorder Society, , Volume: 21, Issue:1, 2006
Pathophysiology of synuclein aggregation in Lewy body disease.Mechanisms of ageing and development, , Volume: 127, Issue:2, 2006
Positive immunoreactivity for vesicular monoamine transporter 2 in Lewy bodies and Lewy neurites in substantia nigra.Neuroscience letters, , Apr-03, Volume: 396, Issue:3, 2006
Clinical and biochemical correlates of insoluble alpha-synuclein in dementia with Lewy bodies.Acta neuropathologica, , Volume: 111, Issue:2, 2006
Antioxidant compounds have potent anti-fibrillogenic and fibril-destabilizing effects for alpha-synuclein fibrils in vitro.Journal of neurochemistry, , Volume: 97, Issue:1, 2006
Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization.Nature chemical biology, , Volume: 2, Issue:5, 2006
REM sleep behavior disorder: a possible early marker for synucleinopathies.Neurology, , Mar-28, Volume: 66, Issue:6, 2006
Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients.Proceedings of the National Academy of Sciences of the United States of America, , Apr-11, Volume: 103, Issue:15, 2006
Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Apr-12, Volume: 26, Issue:15, 2006
Anticipation of onset age in familial Parkinson's disease without SCA gene mutations.Parkinsonism & related disorders, , Volume: 12, Issue:5, 2006
Investigation of Lewy pathology in the visual pathway of brains of dementia with Lewy bodies.Journal of the neurological sciences, , Jul-15, Volume: 246, Issue:1-2, 2006
Biochemical staging of synucleinopathy and amyloid deposition in dementia with Lewy bodies.Journal of neuropathology and experimental neurology, , Volume: 65, Issue:3, 2006
Alzheimer disease with amygdala Lewy bodies: a distinct form of alpha-synucleinopathy.Journal of neuropathology and experimental neurology, , Volume: 65, Issue:7, 2006
Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease.The Journal of biological chemistry, , Oct-06, Volume: 281, Issue:40, 2006
Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease.Neurochemical research, , Volume: 31, Issue:9, 2006
Low alpha-synuclein 126 mRNA levels in dementia with Lewy bodies and Alzheimer disease.Neuroreport, , Aug-21, Volume: 17, Issue:12, 2006
The role of alpha-synuclein gene multiplications in early-onset Parkinson's disease and dementia with Lewy bodies.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 112, Issue:9, 2005
Tuft-shaped astrocytes in Lewy body disease.Acta neuropathologica, , Volume: 109, Issue:4, 2005
Genetic association between the APOE*4 allele and Lewy bodies in Alzheimer disease.Neurology, , Feb-08, Volume: 64, Issue:3, 2005
A mutant PSEN1 causes dementia with Lewy bodies and variant Alzheimer's disease.Annals of neurology, , Volume: 57, Issue:3, 2005
Idiopathic REM sleep behavior disorder: toward a better nosologic definition.Neurology, , Mar-08, Volume: 64, Issue:5, 2005
Abundant neuritic inclusions and microvacuolar changes in a case of diffuse Lewy body disease with the A53T mutation in the alpha-synuclein gene.Acta neuropathologica, , Volume: 110, Issue:3, 2005
Cognitive differences in dementia patients with autopsy-verified AD, Lewy body pathology, or both.Neurology, , Jun-28, Volume: 64, Issue:12, 2005
Abnormal sleep architecture is an early feature in the E46K familial synucleinopathy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20, Issue:10, 2005
Genetics of Parkinson's disease.Annals of medicine, , Volume: 37, Issue:2, 2005
How to diagnose dementia with Lewy bodies: state of the art.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
Alpha-synuclein dysfunction in Lewy body diseases.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
Evidence of oxidative stress in the neocortex in incidental Lewy body disease.Journal of neuropathology and experimental neurology, , Volume: 64, Issue:9, 2005
Non-uniformity in the regional pattern of Lewy pathology in brains of dementia with Lewy bodies.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 25, Issue:3, 2005
Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium.Neurology, , Dec-27, Volume: 65, Issue:12, 2005
Alpha-synuclein and chaperones in dementia with Lewy bodies.Journal of neuropathology and experimental neurology, , Volume: 64, Issue:12, 2005
Novel presenilin 1 mutation (S170F) causing Alzheimer disease with Lewy bodies in the third decade of life.Archives of neurology, , Volume: 62, Issue:12, 2005
Widespread and abundant alpha-synuclein pathology in a neurologically unimpaired subject.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 25, Issue:4, 2005
Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective.The Journal of biological chemistry, , Feb-06, Volume: 279, Issue:6, 2004
Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy.Acta neuropathologica, , Volume: 107, Issue:4, 2004
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia.Annals of neurology, , Volume: 55, Issue:2, 2004
Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity.The Journal of biological chemistry, , Jun-11, Volume: 279, Issue:24, 2004
Early-onset dementia with Lewy bodies.Brain pathology (Zurich, Switzerland), , Volume: 14, Issue:2, 2004
Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease.Neurobiology of disease, , Volume: 16, Issue:1, 2004
SNCA multiplication is not a common cause of Parkinson disease or dementia with Lewy bodies.Neurology, , Aug-10, Volume: 63, Issue:3, 2004
Beta-synuclein gene alterations in dementia with Lewy bodies.Neurology, , Sep-14, Volume: 63, Issue:5, 2004
Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease.Journal of neurochemistry, , Volume: 91, Issue:2, 2004
Lewy body-related alpha-synucleinopathy in the aged human brain.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 111, Issue:10-11, 2004
An antiaggregation gene therapy strategy for Lewy body disease utilizing beta-synuclein lentivirus in a transgenic model.Gene therapy, , Volume: 11, Issue:23, 2004
Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein.FEBS letters, , Oct-22, Volume: 576, Issue:3, 2004
A single amino acid substitution differentiates Hsp70-dependent effects on alpha-synuclein degradation and toxicity.Biochemical and biophysical research communications, , Dec-03, Volume: 325, Issue:1, 2004
Differential expression of alpha-synuclein isoforms in dementia with Lewy bodies.Neuropathology and applied neurobiology, , Volume: 30, Issue:6, 2004
alpha-Synuclein filaments bind the transcriptional regulator HMGB-1.Neuroreport, , Dec-22, Volume: 15, Issue:18, 2004
Abnormal metabotropic glutamate receptor expression and signaling in the cerebral cortex in diffuse Lewy body disease is associated with irregular alpha-synuclein/phospholipase C (PLCbeta1) interactions.Brain pathology (Zurich, Switzerland), , Volume: 14, Issue:4, 2004
Regional distribution of proteinase K-resistant alpha-synuclein correlates with Lewy body disease stage.Journal of neuropathology and experimental neurology, , Volume: 63, Issue:12, 2004
Multiplication of the alpha-synuclein gene is not a common disease mechanism in Lewy body disease.Journal of molecular neuroscience : MN, , Volume: 24, Issue:3, 2004
The Role of alpha-synuclein assembly and metabolism in the pathogenesis of Lewy body disease.Journal of molecular neuroscience : MN, , Volume: 24, Issue:3, 2004
Glial involvement in diffuse Lewy body disease.Acta neuropathologica, , Volume: 105, Issue:2, 2003
Alpha-synuclein, Abeta and Alzheimer's disease.Progress in neuro-psychopharmacology & biological psychiatry, , Volume: 27, Issue:1, 2003
The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease.Neuron, , Feb-20, Volume: 37, Issue:4, 2003
Alpha-synuclein pathology affecting Bergmann glia of the cerebellum in patients with alpha-synucleinopathies.Acta neuropathologica, , Volume: 105, Issue:4, 2003
Lewy body pathology is a frequent co-pathology in familial Alzheimer's disease.Acta neuropathologica, , Volume: 105, Issue:5, 2003
Colocalization of tau and alpha-synuclein epitopes in Lewy bodies.Journal of neuropathology and experimental neurology, , Volume: 62, Issue:4, 2003
Developmental stages of cortical Lewy bodies and their relation to axonal transport blockage in brains of patients with dementia with Lewy bodies.Journal of the neurological sciences, , Jul-15, Volume: 211, Issue:1-2, 2003
Alpha-synuclein-positive structures in association with diffuse neurofibrillary tangles with calcification.Neuropathology and applied neurobiology, , Volume: 29, Issue:3, 2003
Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease.Neuropharmacology, , Volume: 45, Issue:1, 2003
Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies.The American journal of pathology, , Volume: 163, Issue:1, 2003
Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis.The American journal of pathology, , Volume: 163, Issue:2, 2003
Age-associated prevalence and risk factors of Lewy body pathology in a general population: the Hisayama study.Acta neuropathologica, , Volume: 106, Issue:4, 2003
Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of alpha-synuclein.Brain pathology (Zurich, Switzerland), , Volume: 13, Issue:3, 2003
Neuropathological spectrum of synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 18 Suppl 6, 2003
Alpha-synuclein accumulates in Purkinje cells in Lewy body disease but not in multiple system atrophy.Journal of neuropathology and experimental neurology, , Volume: 62, Issue:8, 2003
Tau pathology in the olfactory bulb correlates with Braak stage, Lewy body pathology and apolipoprotein epsilon4.Neuropathology and applied neurobiology, , Volume: 29, Issue:5, 2003
[Lewy bodies, a misleading marker for Parkinson's disease?].Bulletin de l'Academie nationale de medecine, , Volume: 187, Issue:2, 2003
Neuritic alterations and neural system dysfunction in Alzheimer's disease and dementia with Lewy bodies.Neurochemical research, , Volume: 28, Issue:11, 2003
Cycles of aberrant synaptic sprouting and neurodegeneration in Alzheimer's and dementia with Lewy bodies.Neurochemical research, , Volume: 28, Issue:11, 2003
Relationship in the formation process between neurofibrillary tangles and Lewy bodies in the hippocampus of dementia with Lewy bodies brains.Journal of the neurological sciences, , Mar-15, Volume: 195, Issue:1, 2002
Familial diffuse Lewy body disease, eye movement abnormalities, and distribution of pathology.Archives of neurology, , Volume: 59, Issue:3, 2002
14-3-3 proteins in Lewy bodies in Parkinson disease and diffuse Lewy body disease brains.Journal of neuropathology and experimental neurology, , Volume: 61, Issue:3, 2002
Progression and staging of Lewy pathology in brains from patients with dementia with Lewy bodies.Journal of the neurological sciences, , Mar-30, Volume: 195, Issue:2, 2002
Patterns of protein nitration in dementia with Lewy bodies and striatonigral degeneration.Acta neuropathologica, , Volume: 103, Issue:5, 2002
Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters.Journal of neuroscience research, , Jun-01, Volume: 68, Issue:5, 2002
[alpha-synuclein and Parkinson's disease].Seikagaku. The Journal of Japanese Biochemical Society, , Volume: 74, Issue:6, 2002
Structure/function of alpha-synuclein in health and disease: rational development of animal models for Parkinson's and related diseases.Journal of neurochemistry, , Volume: 82, Issue:3, 2002
Clusterin/apolipoprotein J is associated with cortical Lewy bodies: immunohistochemical study in cases with alpha-synucleinopathies.Acta neuropathologica, , Volume: 104, Issue:3, 2002
Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases.Annals of neurology, , Volume: 52, Issue:2, 2002
Genetics of parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Volume: 17, Issue:4, 2002
Nonselenium glutathione peroxidase in human brain : elevated levels in Parkinson's disease and dementia with lewy bodies.The American journal of pathology, , Volume: 161, Issue:3, 2002
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How an Infection of Sheep Revealed Prion Mechanisms in Alzheimer's Disease and Other Neurodegenerative Disorders.International journal of molecular sciences, , May-04, Volume: 22, Issue:9, 2021
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Clinicopathological Study of Patients With C9ORF72-Associated Frontotemporal Dementia Presenting With Delusions.Journal of geriatric psychiatry and neurology, , Volume: 28, Issue:2, 2015
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Extracellular vesicle biomarkers for cognitive impairment in Parkinson's disease.Brain : a journal of neurology, , 01-05, Volume: 146, Issue:1, 2023
Cerebral Microvascular Injury Induced by Lag3-Dependent α-Synuclein Fibril Endocytosis Exacerbates Cognitive Impairment in a Mouse Model of α-Synucleinopathies.Advanced science (Weinheim, Baden-Wurttemberg, Germany), , Volume: 10, Issue:25, 2023
How should we be using biomarkers in trials of disease modification in Parkinson's disease?Brain : a journal of neurology, , Dec-01, Volume: 146, Issue:12, 2023
Kinetic parameters of alpha-synuclein seed amplification assay correlate with cognitive impairment in patients with Lewy body disorders.Acta neuropathologica communications, , 10-09, Volume: 11, Issue:1, 2023
The Mediating Role of Inflammation in the Relationship Between α-Synuclein and Cognitive Functioning.The journals of gerontology. Series A, Biological sciences and medical sciences, , 02-24, Volume: 78, Issue:2, 2023
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Biomarkers Related to Synaptic Dysfunction to Discriminate Alzheimer's Disease from Other Neurological Disorders.International journal of molecular sciences, , Sep-16, Volume: 23, Issue:18, 2022
Plasma total tau predicts executive dysfunction in Parkinson's disease.Acta neurologica Scandinavica, , Volume: 145, Issue:1, 2022
Diagnosis and Treatment of Cognitive and Neuropsychiatric Symptoms in Parkinson Disease and Dementia With Lewy Bodies.Continuum (Minneapolis, Minn.), , Oct-01, Volume: 28, Issue:5, 2022
Exploring the brain metabolic correlates of process-specific CSF biomarkers in patients with MCI due to Alzheimer's disease: preliminary data.Neurobiology of aging, , Volume: 117, 2022
A task-specific cognitive domain decline is correlated with plasma and neuroimaging markers in patients with Parkinson's disease.Journal of neurology, , Volume: 269, Issue:12, 2022
A53T α-synuclein induces neurogenesis impairment and cognitive dysfunction in line M83 transgenic mice and reduces the proliferation of embryonic neural stem cells.Brain research bulletin, , Volume: 182, 2022
Norovirus Intestinal Infection and Lewy Body Disease in an Older Patient with Acute Cognitive Impairment.International journal of molecular sciences, , Jul-29, Volume: 23, Issue:15, 2022
The Intranigral Infusion of Human-Alpha Synuclein Oligomers Induces a Cognitive Impairment in Rats Associated with Changes in Neuronal Firing and Neuroinflammation in the Anterior Cingulate Cortex.Cells, , 08-24, Volume: 11, Issue:17, 2022
Diagnostic Value of the CSF α-Synuclein Real-Time Quaking-Induced Conversion Assay at the Prodromal MCI Stage of Dementia With Lewy Bodies.Neurology, , 08-31, Volume: 97, Issue:9, 2021
Investigating the relationship between the SNCA gene and cognitive abilities in idiopathic Parkinson's disease using machine learning.Scientific reports, , 03-01, Volume: 11, Issue:1, 2021
Clinicopathological investigation of the background of cognitive decline in elderly schizophrenia.Acta neuropsychiatrica, , Volume: 33, Issue:2, 2021
Novel blood test for early biomarkers of preeclampsia and Alzheimer's disease.Scientific reports, , 08-05, Volume: 11, Issue:1, 2021
Lower Plasma α-Synuclein Levels are Associated with Cognitive Impairment in Parkinson's Disease.Clinical laboratory, , May-01, Volume: 67, Issue:5, 2021
The Association Between Plasma α-Synuclein (α-syn) Protein, Urinary Alzheimer-Associated Neuronal Thread Protein (AD7c-NTP), and Apolipoprotein Epsilon 4 (ApoE ε4) Alleles and Cognitive Decline in 60 Patients with Alzheimer's Disease Compared with 28 Age-Medical science monitor : international medical journal of experimental and clinical research, , Jul-27, Volume: 27, 2021
The α-Synuclein Origin and Connectome Model (SOC Model) of Parkinson's Disease: Explaining Motor Asymmetry, Non-Motor Phenotypes, and Cognitive Decline.Journal of Parkinson's disease, , Volume: 11, Issue:2, 2021
Disrupted metabolic connectivity in dopaminergic and cholinergic networks at different stages of dementia from Scientific reports, , 03-08, Volume: 11, Issue:1, 2021
Crucial Role of FABP3 in αSyn-Induced Reduction of Septal GABAergic Neurons and Cognitive Decline in Mice.International journal of molecular sciences, , Jan-01, Volume: 22, Issue:1, 2021
Oral Administration of Silibinin Ameliorates Cognitive Deficits of Parkinson's Disease Mouse Model by Restoring Mitochondrial Disorders in Hippocampus.Neurochemical research, , Volume: 46, Issue:9, 2021
Four Common Late-Life Cognitive Trajectories Patterns Associate with Replicable Underlying Neuropathologies.Journal of Alzheimer's disease : JAD, , Volume: 82, Issue:2, 2021
Autonomic dysfunction is associated with neuropsychological impairment in Lewy body disease.Journal of neurology, , Volume: 267, Issue:7, 2020
Hippocampal α-synuclein pathology correlates with memory impairment in multiple system atrophy.Brain : a journal of neurology, , 06-01, Volume: 143, Issue:6, 2020
Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology.Neuron, , 01-22, Volume: 105, Issue:2, 2020
Pathologically Decreased CSF Levels of Synaptic Marker NPTX2 in DLB Are Correlated with Levels of Alpha-Synuclein and VGF.Cells, , 12-29, Volume: 10, Issue:1, 2020
Characterization of a pathogenic variant in GBA for Parkinson's disease with mild cognitive impairment patients.Molecular brain, , 07-08, Volume: 13, Issue:1, 2020
Mixed Brain Pathology Is the Most Common Cause of Cognitive Impairment in the Elderly.Journal of Alzheimer's disease : JAD, , Volume: 78, Issue:1, 2020
Blood biomarkers of traumatic brain injury and cognitive impairment in older veterans.Neurology, , 09-01, Volume: 95, Issue:9, 2020
Novel fatty acid-binding protein 3 ligand inhibits dopaminergic neuronal death and improves motor and cognitive impairments in Parkinson's disease model mice.Pharmacology, biochemistry, and behavior, , Volume: 191, 2020
Modelling cognitive deficits in Parkinson's disease: Is CA2 a gateway for hippocampal synucleinopathy?Experimental neurology, , Volume: 330, 2020
Classifications of Neurodegenerative Disorders Using a Multiplex Blood Biomarkers-Based Machine Learning Model.International journal of molecular sciences, , Sep-21, Volume: 21, Issue:18, 2020
Degree of genetic liability for Alzheimer's disease associated with specific proteomic profiles in cerebrospinal fluid.Neurobiology of aging, , Volume: 93, 2020
Integrated Plasma and Neuroimaging Biomarkers Associated with Motor and Cognition Severity in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 10, Issue:1, 2020
Unified Staging System for Lewy Body Disorders: Clinicopathologic Correlations and Comparison to Braak Staging.Journal of neuropathology and experimental neurology, , 10-01, Volume: 78, Issue:10, 2019
α-synuclein in the pathophysiology of Alzheimer's disease.Molecular neurodegeneration, , 06-11, Volume: 14, Issue:1, 2019
Measurement of CSF α-synuclein improves early differential diagnosis of mild cognitive impairment due to Alzheimer's disease.Journal of neurochemistry, , Volume: 150, Issue:2, 2019
CSF Biomarkers for Early Diagnosis of Synucleinopathies: Focus on Idiopathic RBD.Current neurology and neuroscience reports, , 01-14, Volume: 19, Issue:2, 2019
A Genome-Wide Association Study of α-Synuclein Levels in Cerebrospinal Fluid.Neurotoxicity research, , Volume: 35, Issue:1, 2019
Lasting spatial learning and memory deficits following chronic cerebral hypoperfusion are associated with hippocampal mitochondrial aging in rats.Neuroscience, , 09-01, Volume: 415, 2019
SNCA Rep1 promoter variability influences cognition in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:8, 2019
Visual discrimination impairment after experimental stroke is associated with disturbances in the polarization of the astrocytic aquaporin-4 and increased accumulation of neurotoxic proteins.Experimental neurology, , Volume: 318, 2019
Baseline concentration of misfolded α-synuclein aggregates in cerebrospinal fluid predicts risk of cognitive decline in Parkinson's disease.Neuropathology and applied neurobiology, , Volume: 45, Issue:4, 2019
Seeding of protein aggregation causes cognitive impairment in rat model of cortical synucleinopathy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:11, 2019
Studying Parkinson's disease using Caenorhabditis elegans models in microfluidic devices.Integrative biology : quantitative biosciences from nano to macro, , 05-01, Volume: 11, Issue:5, 2019
Hippocampal CA2 Lewy pathology is associated with cholinergic degeneration in Parkinson's disease with cognitive decline.Acta neuropathologica communications, , 04-25, Volume: 7, Issue:1, 2019
Long Road to Ruin: Noradrenergic Dysfunction in Neurodegenerative Disease.Trends in neurosciences, , Volume: 41, Issue:4, 2018
Cerebral inoculation of human A53T α-synuclein reduces spatial memory decline and amyloid-β aggregation in APP/PS1 transgenic mice of Alzheimer's disease.Brain research bulletin, , Volume: 143, 2018
[GBA mutations and Parkinson's disease].Sheng li xue bao : [Acta physiologica Sinica], , Jun-25, Volume: 70, Issue:3, 2018
Recent advances in neuropathology, biomarkers and therapeutic approach of multiple system atrophy.Journal of neurology, neurosurgery, and psychiatry, , Volume: 89, Issue:2, 2018
Selective cognitive impairment and hyposmia in p.A53T Neurology, , 03-06, Volume: 90, Issue:10, 2018
A Longitudinal Study of Total and Phosphorylated α-Synuclein with Other Biomarkers in Cerebrospinal Fluid of Alzheimer's Disease and Mild Cognitive Impairment.Journal of Alzheimer's disease : JAD, , Volume: 61, Issue:4, 2018
The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease.Acta neuropathologica communications, , 11-26, Volume: 6, Issue:1, 2018
Evolution of cerebrospinal fluid total α-synuclein in Parkinson's disease.Parkinsonism & related disorders, , Volume: 49, 2018
Plasma α-synuclein and cognitive impairment in the Parkinson's Associated Risk Syndrome: A pilot study.Neurobiology of disease, , Volume: 116, 2018
The "when" and "where" of α-synucleinopathies: Insights from REM sleep behavior disorder.Neurology, , 09-04, Volume: 91, Issue:10, 2018
Neuroprotective effects of voluntary running on cognitive dysfunction in an α-synuclein rat model of Parkinson's disease.Neurobiology of aging, , Volume: 65, 2018
Neuropathology and cognitive performance in self-reported cognitively healthy centenarians.Acta neuropathologica communications, , 07-23, Volume: 6, Issue:1, 2018
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'Under pressure': is there a link between orthostatic hypotension and cognitive impairment in α-synucleinopathies?Journal of neurology, neurosurgery, and psychiatry, , Volume: 87, Issue:12, 2016
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Norovirus Intestinal Infection and Lewy Body Disease in an Older Patient with Acute Cognitive Impairment.International journal of molecular sciences, , Jul-29, Volume: 23, Issue:15, 2022
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Repurposing Pomalidomide as a Neuroprotective Drug: Efficacy in an Alpha-Synuclein-Based Model of Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 19, Issue:1, 2022
Innovative treatment targeting gangliosides aimed at blocking the formation of neurotoxic α-synuclein oligomers in Parkinson's disease.Glycoconjugate journal, , Volume: 39, Issue:1, 2022
Mesoscale connections and gene expression empower whole-brain modeling of α-synuclein spread, aggregation, and decay dynamics.Cell reports, , 11-08, Volume: 41, Issue:6, 2022
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The potential neuroprotective effect of diosmin in rotenone-induced model of Parkinson's disease in rats.European journal of pharmacology, , Jan-05, Volume: 914, 2022
Consistent skin α-synuclein positivity in REM sleep behavior disorder - A two center two-to-four-year follow-up study.Parkinsonism & related disorders, , Volume: 86, 2021
A Disease Progression Model to Quantify the Nonmotor Symptoms of Parkinson's Disease in Participants With Leucine-Rich Repeat Kinase 2 Mutation.Clinical pharmacology and therapeutics, , Volume: 110, Issue:2, 2021
Alpha-Synuclein Oligomers and Neurofilament Light Chain Predict Phenoconversion of Pure Autonomic Failure.Annals of neurology, , Volume: 89, Issue:6, 2021
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Investigating the relationship between the SNCA gene and cognitive abilities in idiopathic Parkinson's disease using machine learning.Scientific reports, , 03-01, Volume: 11, Issue:1, 2021
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Midbrain Slice Culture as an Ex Vivo Analysis Platform for Parkinson's Disease.Methods in molecular biology (Clifton, N.J.), , Volume: 2322, 2021
The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model.Nature communications, , 08-11, Volume: 12, Issue:1, 2021
PET imaging reveals early and progressive dopaminergic deficits after intra-striatal injection of preformed alpha-synuclein fibrils in rats.Neurobiology of disease, , Volume: 149, 2021
Significant Overlap of α-Synuclein, Amyloid-β, and Phospho-Tau Pathologies in Neuropathological Diagnosis of Lewy-related Pathology: Evidence from China Human Brain Bank.Journal of Alzheimer's disease : JAD, , Volume: 80, Issue:1, 2021
Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder.The Lancet. Neurology, , Volume: 20, Issue:8, 2021
Temporal trajectory of biofluid markers in Parkinson's disease.Scientific reports, , 07-20, Volume: 11, Issue:1, 2021
Impaired meningeal lymphatic drainage in patients with idiopathic Parkinson's disease.Nature medicine, , Volume: 27, Issue:3, 2021
High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson's disease.Acta neuropathologica communications, , 11-06, Volume: 9, Issue:1, 2021
Expression Levels of an Alpha-Synuclein Transcript in Blood May Distinguish between Early Dementia with Lewy Bodies and Parkinson's Disease.International journal of molecular sciences, , Jan-13, Volume: 22, Issue:2, 2021
Electron Microscopic Analysis of α-Synuclein Fibrils.Methods in molecular biology (Clifton, N.J.), , Volume: 2322, 2021
The Intersection of Parkinson's Disease, Viral Infections, and COVID-19.Molecular neurobiology, , Volume: 58, Issue:9, 2021
Four Common Late-Life Cognitive Trajectories Patterns Associate with Replicable Underlying Neuropathologies.Journal of Alzheimer's disease : JAD, , Volume: 82, Issue:2, 2021
CD8 T cell nigral infiltration precedes synucleinopathy in early stages of Parkinson's disease.Brain : a journal of neurology, , 12-01, Volume: 143, Issue:12, 2020
Prolyl oligopeptidase inhibition by KYP-2407 increases alpha-synuclein fibril degradation in neuron-like cells.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 131, 2020
Neuron-Astrocyte Interactions in Parkinson's Disease.Cells, , 12-07, Volume: 9, Issue:12, 2020
Copper Ions and Parkinson's Disease: Why Is Homeostasis So Relevant?Biomolecules, , 01-29, Volume: 10, Issue:2, 2020
Systemic activation of NLRP3 inflammasome and plasma α-synuclein levels are correlated with motor severity and progression in Parkinson's disease.Journal of neuroinflammation, , Jan-08, Volume: 17, Issue:1, 2020
[Current Status and Future Prospects of Therapeutic Development of Parkinson's Disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:1, 2020
MRI-visible perivascular spaces are associated with cerebrospinal fluid biomarkers in Parkinson's disease.Aging, , 11-25, Volume: 12, Issue:24, 2020
Cerebrospinal fluid α-synuclein predicts neurodegeneration and clinical progression in non-demented elders.Translational neurodegeneration, , 11-23, Volume: 9, Issue:1, 2020
Astrocytes in Parkinson's disease: from preclinical assays to in vivo imaging and therapeutic probes.Neurobiology of aging, , Volume: 95, 2020
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Erythrocytic α-synuclein contained in microvesicles regulates astrocytic glutamate homeostasis: a new perspective on Parkinson's disease pathogenesis.Acta neuropathologica communications, , 07-08, Volume: 8, Issue:1, 2020
Enhancing the Activity of Glucocerebrosidase as a Treatment for Parkinson Disease.CNS drugs, , Volume: 34, Issue:9, 2020
Subtypes of dementia with Lewy bodies are associated with α-synuclein and tau distribution.Neurology, , 07-14, Volume: 95, Issue:2, 2020
Experimental models of prion-like protein propagation.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 40, Issue:5, 2020
Open questions on the nature of Parkinson's disease: from triggers to spreading pathology.Journal of medical genetics, , Volume: 57, Issue:2, 2020
Immunization therapies for Parkinson's disease: state of the art and considerations for future clinical trials.Expert opinion on investigational drugs, , Volume: 29, Issue:7, 2020
Alpha-Synuclein and LRRK2 in Synaptic Autophagy: Linking Early Dysfunction to Late-Stage Pathology in Parkinson's Disease.Cells, , 04-30, Volume: 9, Issue:5, 2020
Insulin Resistance Promotes Parkinson's Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling.Cells, , 03-17, Volume: 9, Issue:3, 2020
The role of tissue biopsy as a biomarker in REM sleep behavior disorder.Sleep medicine reviews, , Volume: 51, 2020
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Role of Alcohol Drinking in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis.International journal of molecular sciences, , Mar-27, Volume: 21, Issue:7, 2020
Initiation and propagation of α-synuclein aggregation in the nervous system.Molecular neurodegeneration, , 03-06, Volume: 15, Issue:1, 2020
Exosomes from patients with Parkinson's disease are pathological in mice.Journal of molecular medicine (Berlin, Germany), , Volume: 97, Issue:9, 2019
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Precision Medicine in Rapid Eye Movement Sleep Behavior Disorder.Sleep medicine clinics, , Volume: 14, Issue:3, 2019
CSF Biomarkers for Early Diagnosis of Synucleinopathies: Focus on Idiopathic RBD.Current neurology and neuroscience reports, , 01-14, Volume: 19, Issue:2, 2019
Early disease course is unaltered in mucopolysaccharidosis type IIIA (MPS IIIA) mice lacking α-synuclein.Neuropathology and applied neurobiology, , Volume: 45, Issue:7, 2019
Neuropathological and genetic characteristics of a post-mortem series of cases with dementia with Lewy bodies clinically suspected of Creutzfeldt-Jakob's disease.Parkinsonism & related disorders, , Volume: 63, 2019
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Oxidative stress and α-synuclein conspire in vulnerable neurons to promote Parkinson's disease progression.The Journal of clinical investigation, , 08-05, Volume: 129, Issue:9, 2019
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Histamine-4 receptor antagonist JNJ7777120 inhibits pro-inflammatory microglia and prevents the progression of Parkinson-like pathology and behaviour in a rat model.Brain, behavior, and immunity, , Volume: 76, 2019
Studying Parkinson's disease using Caenorhabditis elegans models in microfluidic devices.Integrative biology : quantitative biosciences from nano to macro, , 05-01, Volume: 11, Issue:5, 2019
Feasibility of repeat and bilateral submandibular gland needle biopsies in Parkinson's disease.Parkinsonism & related disorders, , Volume: 68, 2019
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Oxidative stress in vagal neurons promotes parkinsonian pathology and intercellular α-synuclein transfer.The Journal of clinical investigation, , 06-13, Volume: 129, Issue:9, 2019
Slow Progressive Accumulation of Oligodendroglial Alpha-Synuclein (α-Syn) Pathology in Synthetic α-Syn Fibril-Induced Mouse Models of Synucleinopathy.Journal of neuropathology and experimental neurology, , 10-01, Volume: 78, Issue:10, 2019
Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression.Acta neuropathologica communications, , 09-02, Volume: 7, Issue:1, 2019
The prion-like spreading of α-synuclein: From in vitro to in vivo models of Parkinson's disease.Ageing research reviews, , Volume: 50, 2019
Parkinson's disease: a short story of 200 years.Histology and histopathology, , Volume: 34, Issue:6, 2019
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Suppression of autophagy in the brain of transgenic mice with overexpression of А53Т-mutant α-synuclein as an early event at synucleinopathy progression.Neuroscience letters, , 04-13, Volume: 672, 2018
REM behavior disorder predicts motor progression and cognitive decline in Parkinson disease.Neurology, , 09-04, Volume: 91, Issue:10, 2018
Susceptibility MRI captures nigral pathology in patients with parkinsonian syndromes.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:9, 2018
Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term.Acta neuropathologica, , Volume: 135, Issue:1, 2018
The "when" and "where" of α-synucleinopathies: Insights from REM sleep behavior disorder.Neurology, , 09-04, Volume: 91, Issue:10, 2018
Brains with sporadic Creutzfeldt-Jakob disease and copathology showed a prolonged end-stage of disease.Journal of clinical pathology, , Volume: 71, Issue:5, 2018
Relationship between cerebrospinal fluid biomarkers and structural brain network properties in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:3, 2018
Regional expression of genes mediating trans-synaptic alpha-synuclein transfer predicts regional atrophy in Parkinson disease.NeuroImage. Clinical, , Volume: 18, 2018
A Longitudinal Study of Total and Phosphorylated α-Synuclein with Other Biomarkers in Cerebrospinal Fluid of Alzheimer's Disease and Mild Cognitive Impairment.Journal of Alzheimer's disease : JAD, , Volume: 61, Issue:4, 2018
Updating Our Definitions of Parkinson's Disease for a Molecular Age.Journal of Parkinson's disease, , Volume: 8, Issue:s1, 2018
The limbic and neocortical contribution of α-synuclein, tau, and amyloid β to disease duration in dementia with Lewy bodies.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 14, Issue:3, 2018
The vermiform appendix impacts the risk of developing Parkinson's disease.Science translational medicine, , 10-31, Volume: 10, Issue:465, 2018
D409H GBA1 mutation accelerates the progression of pathology in A53T α-synuclein transgenic mouse model.Acta neuropathologica communications, , 04-27, Volume: 6, Issue:1, 2018
Does Parkinson's disease start in the gut?Arquivos de neuro-psiquiatria, , Volume: 76, Issue:2, 2018
α-Synuclein Oligomers Induce a Unique Toxic Tau Strain.Biological psychiatry, , 10-01, Volume: 84, Issue:7, 2018
Cerebrospinal fluid concentrations of inflammatory markers in Parkinson's disease and atypical parkinsonian disorders.Scientific reports, , 09-05, Volume: 8, Issue:1, 2018
Diabetes mellitus and Parkinson disease.Neurology, , 05-08, Volume: 90, Issue:19, 2018
Evolution of cerebrospinal fluid total α-synuclein in Parkinson's disease.Parkinsonism & related disorders, , Volume: 49, 2018
Prion-like propagation of pathology in Parkinson disease.Handbook of clinical neurology, , Volume: 153, 2018
Localized Induction of Wild-Type and Mutant Alpha-Synuclein Aggregation Reveals Propagation along Neuroanatomical Tracts.Journal of virology, , 09-15, Volume: 92, Issue:18, 2018
Tau/α-synuclein ratio and inflammatory proteins in Parkinson's disease: An exploratory study.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:7, 2017
Progression of alpha-synuclein pathology in multiple system atrophy of the cerebellar type.Neuropathology and applied neurobiology, , Volume: 43, Issue:4, 2017
Aging modifies the effect of GCH1 RS11158026 on DAT uptake and Parkinson's disease clinical severity.Neurobiology of aging, , Volume: 50, 2017
Familial Mutations and Post-translational Modifications of UCH-L1 in Parkinson's Disease and Neurodegenerative Disorders.Current protein & peptide science, , Volume: 18, Issue:7, 2017
Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders.Pharmacology & therapeutics, , Volume: 172, 2017
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Pathological α-synuclein exacerbates the progression of Parkinson's disease through microglial activation.Toxicology letters, , Jan-04, Volume: 265, 2017
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α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading.Acta neuropathologica, , Volume: 134, Issue:5, 2017
Decrease in Aβ42 predicts dopa-resistant gait progression in early Parkinson disease.Neurology, , Apr-18, Volume: 88, Issue:16, 2017
An alpha-synuclein MRM assay with diagnostic potential for Parkinson's disease and monitoring disease progression.Proteomics. Clinical applications, , Volume: 11, Issue:7-8, 2017
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A Systems Model of Parkinson's Disease Using Biochemical Systems Theory.Omics : a journal of integrative biology, , Volume: 21, Issue:8, 2017
An order in Lewy body disorders: Retrograde degeneration in hyperbranching axons as a fundamental structural template accounting for focal/multifocal Lewy body disease.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 37, Issue:2, 2017
Hypothalamic α-synuclein and its relation to weight loss and autonomic symptoms in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:2, 2017
Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson's disease?Acta neuropathologica communications, , 09-13, Volume: 5, Issue:1, 2017
Reduced TH expression and α-synuclein accumulation contribute towards nigrostriatal dysfunction in experimental hepatic encephalopathy.Restorative neurology and neuroscience, , Volume: 35, Issue:5, 2017
Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model.Acta neuropathologica communications, , 08-22, Volume: 4, Issue:1, 2016
The role of biomarkers and imaging in Parkinson's disease.Expert review of neurotherapeutics, , Volume: 16, Issue:2, 2016
A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein.Molecular neurodegeneration, , 08-22, Volume: 11, Issue:1, 2016
Longitudinal Measurements of Cerebrospinal Fluid Biomarkers in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:6, 2016
α-Synuclein: Experimental Pathology.Cold Spring Harbor perspectives in medicine, , Sep-01, Volume: 6, Issue:9, 2016
Longitudinal changes in CSF alpha-synuclein species reflect Parkinson's disease progression.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:10, 2016
Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles.PloS one, , Volume: 11, Issue:6, 2016
Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson's disease.The Journal of experimental medicine, , 08-22, Volume: 213, Issue:9, 2016
Pure Autonomic Failure.Current neurology and neuroscience reports, , Volume: 16, Issue:8, 2016
Chronic mild stress accelerates the progression of Parkinson's disease in A53T α-synuclein transgenic mice.Experimental neurology, , Volume: 285, Issue:Pt A, 2016
Variants in the SNCA gene associate with motor progression while variants in the MAPT gene associate with the severity of Parkinson's disease.Parkinsonism & related disorders, , Volume: 24, 2016
Two hundred steps.Nature, , 10-27, Volume: 538, Issue:7626, 2016
Dynamic Changes in Striatal mGluR1 But Not mGluR5 during Pathological Progression of Parkinson's Disease in Human Alpha-Synuclein A53T Transgenic Rats: A Multi-PET Imaging Study.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jan-13, Volume: 36, Issue:2, 2016
Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.Neuron, , 07-06, Volume: 91, Issue:1, 2016
Parkinson's disease: 4 big questions.Nature, , 10-27, Volume: 538, Issue:7626, 2016
Review: Spreading the word: precise animal models and validated methods are vital when evaluating prion-like behaviour of alpha-synuclein.Neuropathology and applied neurobiology, , Volume: 42, Issue:1, 2016
Review: Sporadic Parkinson's disease: development and distribution of α-synuclein pathology.Neuropathology and applied neurobiology, , Volume: 42, Issue:1, 2016
Variants in GBA, SNCA, and MAPT influence Parkinson disease risk, age at onset, and progression.Neurobiology of aging, , Volume: 37, 2016
Progression of Behavioral and CNS Deficits in a Viable Murine Model of Chronic Neuronopathic Gaucher Disease.PloS one, , Volume: 11, Issue:9, 2016
Longitudinal live imaging of retinal α-synuclein::GFP deposits in a transgenic mouse model of Parkinson's Disease/Dementia with Lewy Bodies.Scientific reports, , 07-08, Volume: 6, 2016
Biomarkers of Parkinson's disease: present and future.Metabolism: clinical and experimental, , Volume: 64, Issue:3 Suppl 1, 2015
α-Synuclein staging in the amygdala of a Parkinson's disease model: cell types involved.The European journal of neuroscience, , Volume: 41, Issue:1, 2015
Environment-contact administration of rotenone: A new rodent model of Parkinson's disease.Behavioural brain research, , Nov-01, Volume: 294, 2015
Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice.Molecular neurodegeneration, , Jul-30, Volume: 10, 2015
Novel therapeutic approaches in multiple system atrophy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 25, Issue:1, 2015
Common pathophysiology affecting diabetic retinopathy and Parkinson's disease.Medical hypotheses, , Volume: 85, Issue:4, 2015
Targeting α-synuclein as a therapeutic strategy for Parkinson's disease.Expert opinion on therapeutic targets, , Volume: 19, Issue:10, 2015
[Subtypes of mild cognitive impairment in Parkinson's disease and factors predicting its becoming dementia].Revista de neurologia, , Jul-01, Volume: 61, Issue:1, 2015
Phosphorylated α-synuclein in Parkinson's disease: correlation depends on disease severity.Acta neuropathologica communications, , Jan-31, Volume: 3, 2015
CSF biomarkers and clinical progression of Parkinson disease.Neurology, , Jan-06, Volume: 84, Issue:1, 2015
Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors.Neurobiology of aging, , Volume: 36, Issue:3, 2015
The use of cerebrospinal fluid and neuropathologic studies in neuropsychiatry practice and research.The Psychiatric clinics of North America, , Volume: 38, Issue:2, 2015
Parkinson's disease and alpha-synucleinopathies: from arising pathways to therapeutic challenge.Central nervous system agents in medicinal chemistry, , Volume: 15, Issue:2, 2015
Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation.Molecular neurodegeneration, , Aug-27, Volume: 10, 2015
Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice.Neurobiology of aging, , Volume: 35, Issue:11, 2014
Systems-based analyses of brain regions functionally impacted in Parkinson's disease reveals underlying causal mechanisms.PloS one, , Volume: 9, Issue:8, 2014
Non-motor parkinsonian pathology in aging A53T α-synuclein mice is associated with progressive synucleinopathy and altered enzymatic function.Journal of neurochemistry, , Volume: 128, Issue:4, 2014
Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:8, 2014
Cerebrospinal fluid α-synuclein predicts cognitive decline in Parkinson disease progression in the DATATOP cohort.The American journal of pathology, , Volume: 184, Issue:4, 2014
A 'bird's eye' view on the current status and potential benefits of blood biomarkers for Parkinson's disease.Biomarkers in medicine, , Volume: 8, Issue:2, 2014
The significance of α-synuclein, amyloid-β and tau pathologies in Parkinson's disease progression and related dementia.Neuro-degenerative diseases, , Volume: 13, Issue:2-3, 2014
Staged pathology in Parkinson's disease.Parkinsonism & related disorders, , Volume: 20 Suppl 1, 2014
Modeling Lewy pathology propagation in Parkinson's disease.Parkinsonism & related disorders, , Volume: 20 Suppl 1, 2014
Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneurons.PloS one, , Volume: 9, Issue:7, 2014
Panax ginseng is neuroprotective in a novel progressive model of Parkinson's disease.Experimental gerontology, , Volume: 50, 2014
Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:10, 2014
Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.Acta neuropathologica, , Volume: 128, Issue:6, 2014
The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset.Acta neuropathologica, , Volume: 127, Issue:5, 2014
Bladder dysfunction in a transgenic mouse model of multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:3, 2013
Changes in amyloid-β and Tau in the cerebrospinal fluid of transgenic mice overexpressing amyloid precursor protein.Science translational medicine, , Jul-17, Volume: 5, Issue:194, 2013
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CSF α-synuclein improves diagnostic and prognostic performance of CSF tau and Aβ in Alzheimer's disease.Acta neuropathologica, , Volume: 126, Issue:5, 2013
The genetics of Parkinson's disease: progress and therapeutic implications.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:1, 2013
α-synuclein imaging: a critical need for Parkinson's disease research.Journal of Parkinson's disease, , Volume: 3, Issue:4, 2013
α-Synuclein vaccination prevents the accumulation of parkinson disease-like pathologic inclusions in striatum in association with regulatory T cell recruitment in a rat model.Journal of neuropathology and experimental neurology, , Volume: 72, Issue:7, 2013
Gender differences in Parkinson's disease: focus on plasma α-synuclein.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 120, Issue:8, 2013
Commentary: Progressive inflammation as a contributing factor to early development of Parkinson's disease.Experimental neurology, , Volume: 241, 2013
Dysfunction of the locus coeruleus-norepinephrine system and related circuitry in Parkinson's disease-related dementia.Journal of neurology, neurosurgery, and psychiatry, , Volume: 84, Issue:7, 2013
α-Synuclein: the long distance runner.Brain pathology (Zurich, Switzerland), , Volume: 23, Issue:3, 2013
The potential prognostic role of cardiovascular autonomic failure in α-synucleinopathies.European journal of neurology, , Volume: 20, Issue:2, 2013
A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats.Brain : a journal of neurology, , Volume: 136, Issue:Pt 2, 2013
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Neuropathological investigation of the hypometabolic regions on positron emission tomography with [18F] fluorodeoxyglucose in patients with dementia with Lewy bodies.Journal of the neurological sciences, , Mar-15, Volume: 314, Issue:1-2, 2012
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α-Synuclein levels modulate Huntington's disease in mice.Human molecular genetics, , Feb-01, Volume: 21, Issue:3, 2012
A progressive mouse model of Parkinson's disease: the Thy1-aSyn ("Line 61") mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 9, Issue:2, 2012
Possible alterations in β-Synuclein, the non-amyloidogenic homologue of α-Synuclein, during progression of sporadic α-synucleinopathies.International journal of molecular sciences, , Volume: 13, Issue:9, 2012
Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 22, Issue:1, 2012
Amyloid generation and dysfunctional immunoproteasome activation with disease progression in animal model of familial Alzheimer's disease.Brain pathology (Zurich, Switzerland), , Volume: 22, Issue:5, 2012
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Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons.Neurobiology of disease, , Volume: 45, Issue:3, 2012
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Patterns of α-synuclein pathology in incidental cases and clinical subtypes of Parkinson's disease.Parkinsonism & related disorders, , Volume: 18 Suppl 1, 2012
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α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jul-06, Volume: 31, Issue:27, 2011
α-Synuclein deficiency and efferent nerve degeneration in the mouse cochlea: a possible cause of early-onset presbycusis.Neuroscience research, , Volume: 71, Issue:3, 2011
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Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α-synuclein.Journal of neuroscience research, , Volume: 89, Issue:7, 2011
Redox activity of α-synuclein-Cu is silenced by Zn₇-metallothionein-3.Free radical biology & medicine, , Jun-01, Volume: 50, Issue:11, 2011
The oxysterol 27-hydroxycholesterol regulates α-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors--relevance to Parkinson's disease.Journal of neurochemistry, , Volume: 119, Issue:5, 2011
Epidemiological neuropathology: the MRC Cognitive Function and Aging Study experience.Journal of Alzheimer's disease : JAD, , Volume: 25, Issue:2, 2011
Interaction between α-synuclein and tau genotypes and the progression of Parkinson's disease.Journal of Parkinson's disease, , Volume: 1, Issue:3, 2011
Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression.Annals of neurology, , Volume: 69, Issue:3, 2011
Clinical course of the first Asian family with Parkinsonism related to SNCA triplication.Movement disorders : official journal of the Movement Disorder Society, , Dec-15, Volume: 25, Issue:16, 2010
Prediction of pathology in primary progressive language and speech disorders.Neurology, , Jan-05, Volume: 74, Issue:1, 2010
Pure autonomic failure: a restricted Lewy body synucleinopathy or early Parkinson disease?Neurology, , Feb-16, Volume: 74, Issue:7, 2010
Upregulation of alpha-synuclein expression in the rat cerebellum in experimental hepatic encephalopathy.Neuropathology and applied neurobiology, , Volume: 36, Issue:5, 2010
The progression of pathology in Parkinson's disease.Annals of the New York Academy of Sciences, , Volume: 1184, 2010
Synergistic effects of environmental risk factors and gene mutations in Parkinson's disease accelerate age-related neurodegeneration.Journal of neurochemistry, , Volume: 115, Issue:6, 2010
Neuroimaging for Lewy body disease: is the in vivo molecular imaging of α-synuclein neuropathology required and feasible?Brain research reviews, , Oct-05, Volume: 65, Issue:1, 2010
Ageing, neurodegeneration and Parkinson's disease.Age and ageing, , Volume: 39, Issue:2, 2010
Expression of alpha-, beta- and gamma-synuclein in colorectal cancer, and potential clinical significance in progression of the disease.Oncology reports, , Volume: 23, Issue:2, 2010
Alpha-synuclein deficiency in the C57BL/6JOlaHsd strain does not modify disease progression in the ME7-model of prion disease.Neuroscience, , Feb-03, Volume: 165, Issue:3, 2010
Recurrent systemic infections with Streptococcus pneumoniae do not aggravate the course of experimental neurodegenerative diseases.Journal of neuroscience research, , Volume: 88, Issue:5, 2010
Viral vector-mediated overexpression of α-synuclein as a progressive model of Parkinson's disease.Progress in brain research, , Volume: 184, 2010
A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death.Neurobiology of aging, , Volume: 31, Issue:1, 2010
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Parkinsonism in hiv-infected patients on highly active antiretroviral therapy.Neurology, , Aug-04, Volume: 73, Issue:5, 2009
Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.Neuron, , Dec-24, Volume: 64, Issue:6, 2009
Recent developments in multiple system atrophy.Journal of neurology, , Volume: 256, Issue:11, 2009
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Early stages for Parkinson's development: alpha-synuclein misfolding and aggregation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 4, Issue:1, 2009
No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Jul-30, Volume: 24, Issue:10, 2009
Concomitant progressive supranuclear palsy and multiple system atrophy: more than a simple twist of fate?Neuroscience letters, , Dec-31, Volume: 467, Issue:3, 2009
Parkin and PINK1 parkinsonism may represent nigral mitochondrial cytopathies distinct from Lewy body Parkinson's disease.Parkinsonism & related disorders, , Volume: 15, Issue:10, 2009
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Relative preservation of thalamic centromedian nucleus in parkinsonian patients with dystonia.Movement disorders : official journal of the Movement Disorder Society, , Oct-30, Volume: 24, Issue:14, 2009
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Research in motion: the enigma of Parkinson's disease pathology spread.Nature reviews. Neuroscience, , Volume: 9, Issue:10, 2008
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Patterns and stages of alpha-synucleinopathy: Relevance in a population-based cohort.Neurology, , Mar-25, Volume: 70, Issue:13, 2008
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease.Nature medicine, , Volume: 14, Issue:5, 2008
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation.Nature medicine, , Volume: 14, Issue:5, 2008
Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Jun-15, Volume: 23, Issue:8, 2008
Striatal beta-amyloid deposition in Parkinson disease with dementia.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:5, 2008
A critical evaluation of the Braak staging scheme for Parkinson's disease.Annals of neurology, , Volume: 64, Issue:5, 2008
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Do alpha-synuclein aggregates in autonomic plexuses predate Lewy body disorders?: a cohort study.Neurology, , Jun-05, Volume: 68, Issue:23, 2007
Classical Parkinson disease versus Parkinson complex--reflections against staging and in favour of heterogeneity.European journal of neurology, , Volume: 14, Issue:7, 2007
A 75-year-old man with cognitive impairment and gait changes.Neurology, , Sep-11, Volume: 69, Issue:11, 2007
Microglial activation mediates neurodegeneration related to oligodendroglial alpha-synucleinopathy: implications for multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Nov-15, Volume: 22, Issue:15, 2007
The pathogenesis of cell death in Parkinson's disease--2007.Movement disorders : official journal of the Movement Disorder Society, , Volume: 22 Suppl 17, 2007
The ups and downs of alpha-synuclein mRNA expression.Movement disorders : official journal of the Movement Disorder Society, , Jan-15, Volume: 22, Issue:2, 2007
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Investigation of Lewy pathology in the visual pathway of brains of dementia with Lewy bodies.Journal of the neurological sciences, , Jul-15, Volume: 246, Issue:1-2, 2006
Parkinsonism, Lrrk2 G2019S, and tau neuropathology.Neurology, , Oct-24, Volume: 67, Issue:8, 2006
Diagnosis and treatment of Parkinson disease: molecules to medicine.The Journal of clinical investigation, , Volume: 116, Issue:7, 2006
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Dementia with Lewy bodies in an elderly Greek male due to alpha-synuclein gene mutation.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, , Volume: 13, Issue:9, 2006
Idiopathic REM sleep behavior disorder: toward a better nosologic definition.Neurology, , Mar-08, Volume: 64, Issue:5, 2005
Cognitive differences in dementia patients with autopsy-verified AD, Lewy body pathology, or both.Neurology, , Jun-28, Volume: 64, Issue:12, 2005
Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease.Brain : a journal of neurology, , Volume: 128, Issue:Pt 11, 2005
Grading of neuropathology in multiple system atrophy: proposal for a novel scale.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
In vitro models of multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
A possible role for humoral immunity in the pathogenesis of Parkinson's disease.Brain : a journal of neurology, , Volume: 128, Issue:Pt 11, 2005
Novel presenilin 1 mutation (S170F) causing Alzheimer disease with Lewy bodies in the third decade of life.Archives of neurology, , Volume: 62, Issue:12, 2005
Viral vector mediated overexpression of human alpha-synuclein in the nigrostriatal dopaminergic neurons: a new model for Parkinson's disease.CNS spectrums, , Volume: 10, Issue:3, 2005
Tissue transglutaminase catalyzes the formation of alpha-synuclein crosslinks in Parkinson's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 18, Issue:7, 2004
Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation.Experimental neurology, , Volume: 187, Issue:2, 2004
Beta-synuclein gene alterations in dementia with Lewy bodies.Neurology, , Sep-14, Volume: 63, Issue:5, 2004
Familial and sporadic Parkinson's disease usually display the same clinical features.Parkinsonism & related disorders, , Volume: 9, Issue:4, 2003
Haploinsufficiency at the alpha-synuclein gene underlies phenotypic severity in familial Parkinson's disease.Brain : a journal of neurology, , Volume: 126, Issue:Pt 1, 2003
Developmental stages of cortical Lewy bodies and their relation to axonal transport blockage in brains of patients with dementia with Lewy bodies.Journal of the neurological sciences, , Jul-15, Volume: 211, Issue:1-2, 2003
Progression and staging of Lewy pathology in brains from patients with dementia with Lewy bodies.Journal of the neurological sciences, , Mar-30, Volume: 195, Issue:2, 2002
Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Apr-01, Volume: 22, Issue:7, 2002
Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice.Experimental neurology, , Volume: 175, Issue:1, 2002
Clinical features of parkinsonian patients with the alpha-synuclein (G209A) mutation.Movement disorders : official journal of the Movement Disorder Society, , Volume: 16, Issue:6, 2001
Degeneration process of Lewy bodies in the brains of patients with dementia with Lewy bodies using alpha-synuclein-immunohistochemistry.Neuroscience letters, , May-26, Volume: 286, Issue:1, 2000
Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease.The American journal of pathology, , Volume: 157, Issue:2, 2000
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Could JC virus be involved in the onset of multiple system atrophy? A hypothesis.Parkinsonism & related disorders, , Volume: 109, 2023
Phosphorylated α-synuclein in skin Schwann cells: a new biomarker for multiple system atrophy.Brain : a journal of neurology, , 03-01, Volume: 146, Issue:3, 2023
Comparison of biospecimens for α-synuclein seed amplification assays in Parkinson's disease: A systematic review and network meta-analysis.European journal of neurology, , Volume: 30, Issue:12, 2023
α-Synuclein Conformational Strains as Drivers of Phenotypic Heterogeneity in Neurodegenerative Diseases.Journal of molecular biology, , 06-15, Volume: 435, Issue:12, 2023
α-Synuclein Strains and Their Relevance to Parkinson's Disease, Multiple System Atrophy, and Dementia with Lewy Bodies.International journal of molecular sciences, , Jul-28, Volume: 24, Issue:15, 2023
Late-onset MSA differs from younger-onset MSA.Journal of neurology, neurosurgery, and psychiatry, , Volume: 94, Issue:7, 2023
Disease-Specific α-Synuclein Seeding in Lewy Body Disease and Multiple System Atrophy Are Preserved in Formaldehyde-Fixed Paraffin-Embedded Human Brain.Biomolecules, , 06-02, Volume: 13, Issue:6, 2023
Propagative α-synuclein seeds as serum biomarkers for synucleinopathies.Nature medicine, , Volume: 29, Issue:6, 2023
⍺-Synuclein Structural Diversity and the Cellular Environment in ⍺-Synuclein Transmission Models and Humans.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 20, Issue:1, 2023
Somatic SNCA Copy Number Variants in Multiple System Atrophy are Related to Pathology and Inclusions.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:2, 2023
Differential involvement of amyloidogenic evolvability in oligodendropathies; Multiple Sclerosis and Multiple System Atrophy.Prion, , Volume: 17, Issue:1, 2023
Beyond Strains: Molecular Diversity in Alpha-Synuclein at the Center of Disease Heterogeneity.International journal of molecular sciences, , Aug-25, Volume: 24, Issue:17, 2023
Truncation or proteolysis of α-synuclein in Parkinsonism.Ageing research reviews, , Volume: 90, 2023
Cancer in pathologically confirmed multiple system atrophy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 33, Issue:4, 2023
A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibrils in Multiple System Atrophy.Journal of medicinal chemistry, , 09-14, Volume: 66, Issue:17, 2023
A Mouse Model of Multiple System Atrophy: Bench to Bedside.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 20, Issue:1, 2023
Alpha-synuclein fibrils amplified from multiple system atrophy and Parkinson's disease patient brain spread after intracerebral injection into mouse brain.Brain pathology (Zurich, Switzerland), , Volume: 33, Issue:5, 2023
Cellular processing of α-synuclein fibrils results in distinct physiological C-terminal truncations with a major cleavage site at residue Glu 114.The Journal of biological chemistry, , Volume: 299, Issue:7, 2023
Generation of TWO G51D SNCA missense mutation iPSC lines (CRICKi011-A, CRICKi012-A) from two individuals at risk of Parkinson's disease.Stem cell research, , Volume: 71, 2023
Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils.Proceedings of the National Academy of Sciences of the United States of America, , 02-14, Volume: 120, Issue:7, 2023
iPSC-Derived Striatal Medium Spiny Neurons from Patients with Multiple System Atrophy Show Hypoexcitability and Elevated α-Synuclein Release.Cells, , 01-04, Volume: 12, Issue:2, 2023
Urinary tract infections trigger synucleinopathy via the innate immune response.Acta neuropathologica, , Volume: 145, Issue:5, 2023
α-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis.Translational neurodegeneration, , 08-25, Volume: 12, Issue:1, 2023
Early and extensive alterations of glial connexins, distal oligodendrogliopathy type demyelination, and nodal/paranodal pathology are characteristic of multiple system atrophy.Brain pathology (Zurich, Switzerland), , Volume: 33, Issue:3, 2023
Blood-Based α-Synuclein Seeding-A New Era for Identifying Parkinsonian Syndromes.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:8, 2023
The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson's disease.Acta neuropathologica communications, , 05-03, Volume: 11, Issue:1, 2023
[Novel Treatment of Multiple System Atrophy in the Era of the New MDS Criteria].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 75, Issue:2, 2023
The morphological substrate of memory impairment in multiple system atrophy.Neuropathology and applied neurobiology, , Volume: 49, Issue:1, 2023
Gut-to-brain spreading of pathology in synucleinopathies: A focus on molecular signalling mediators.Behavioural brain research, , 08-24, Volume: 452, 2023
Oligodendrocytes Prune Axons Containing α-Synuclein Aggregates In Vivo: Lewy Neurites as Precursors of Glial Cytoplasmic Inclusions in Multiple System Atrophy?Biomolecules, , 02-01, Volume: 13, Issue:2, 2023
α-Synuclein emulsifies TDP-43 prion-like domain-RNA liquid droplets to promote heterotypic amyloid fibrils.Communications biology, , Dec-05, Volume: 6, Issue:1, 2023
Differential immunophenotypes of neuronal cytoplasmic inclusions in the dentate gyrus of multiple system atrophy and their association with clinicopathological features.Journal of neuropathology and experimental neurology, , 03-20, Volume: 82, Issue:4, 2023
New SNCA mutation and structures of α-synuclein filaments from juvenile-onset synucleinopathy.Acta neuropathologica, , Volume: 145, Issue:5, 2023
Serotonin in synucleinopathies.Behavioural brain research, , 05-08, Volume: 445, 2023
Evaluation of α-synuclein in CNS-originating extracellular vesicles for Parkinsonian disorders: A systematic review and meta-analysis.CNS neuroscience & therapeutics, , Volume: 29, Issue:12, 2023
Lifelong constipation in Parkinson's disease and other clinically defined alpha-synucleinopathies: A population-based study in Southeast Minnesota.Parkinsonism & related disorders, , Volume: 107, 2023
Epsin2, a novel target for multiple system atrophy therapy via α-synuclein/FABP7 propagation.Brain : a journal of neurology, , 08-01, Volume: 146, Issue:8, 2023
Multiple system atrophy: at the crossroads of cellular, molecular and genetic mechanisms.Nature reviews. Neuroscience, , Volume: 24, Issue:6, 2023
PET imaging in animal models of Parkinson's disease.Behavioural brain research, , 02-13, Volume: 438, 2023
[no title available]Biomolecular NMR assignments, , Volume: 17, Issue:2, 2023
Role of Oligodendrocyte Lineage Cells in Multiple System Atrophy.Cells, , 02-25, Volume: 12, Issue:5, 2023
Monitoring α-synuclein aggregation.Neurobiology of disease, , Volume: 176, 2023
The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases.Nature communications, , 10-27, Volume: 14, Issue:1, 2023
α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies.Translational neurodegeneration, , 03-14, Volume: 12, Issue:1, 2023
GRK2-Targeted Knockdown as Therapy for Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:7, 2023
Host oligodendrogliopathy and α-synuclein strains dictate disease severity in multiple system atrophy.Brain : a journal of neurology, , 01-05, Volume: 146, Issue:1, 2023
High-Contrast Imaging of α-Synuclein Pathologies in Living Patients with Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:10, 2022
In vivo and autopsy validation of alpha-synuclein seeding activity using RT-QuIC assay in the gastrointestinal tract of patients with Parkinson's disease.Parkinsonism & related disorders, , Volume: 103, 2022
Unique seeding profiles and prion-like propagation of synucleinopathies are highly dependent on the host in human α-synuclein transgenic mice.Acta neuropathologica, , Volume: 143, Issue:6, 2022
Hemoglobin-binding α-synuclein levels in erythrocytes are elevated in patients with multiple system atrophy.Neuroscience letters, , 10-15, Volume: 789, 2022
Disease-Modifying Therapies for Multiple System Atrophy: Where Are We in 2022?Journal of Parkinson's disease, , Volume: 12, Issue:5, 2022
Development of an α-synuclein fibril and oligomer specific tracer for diagnosis of Parkinson's disease, dementia with Lewy bodies and multiple system atrophy.Neurochemistry international, , Volume: 161, 2022
Family History for Neurodegeneration in Multiple System Atrophy: Does it Indicate Susceptibility?Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:11, 2022
Combined CSF α-SYN RT-QuIC, CSF NFL and midbrain-pons planimetry in degenerative parkinsonisms: From bedside to bench, and back again.Parkinsonism & related disorders, , Volume: 99, 2022
Multiple system atrophy prions transmit neurological disease to mice expressing wild-type human α-synuclein.Acta neuropathologica, , Volume: 144, Issue:4, 2022
Increased unsaturated lipids underlie lipid peroxidation in synucleinopathy brain.Acta neuropathologica communications, , 11-14, Volume: 10, Issue:1, 2022
α-Synuclein Conformational Plasticity: Physiologic States, Pathologic Strains, and Biotechnological Applications.Biomolecules, , 07-17, Volume: 12, Issue:7, 2022
Synucleinopathy in Amyotrophic Lateral Sclerosis: A Potential Avenue for Antisense Therapeutics?International journal of molecular sciences, , Aug-19, Volume: 23, Issue:16, 2022
Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies.Acta neuropathologica communications, , 06-03, Volume: 10, Issue:1, 2022
Recent advances in establishing fluid biomarkers for the diagnosis and differentiation of alpha-synucleinopathies - a mini review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 32, Issue:4, 2022
Pathological Appearance of a Case of Preclinical Multiple System Atrophy: A Comparison With Advanced Cases.Journal of neuropathology and experimental neurology, , 11-16, Volume: 81, Issue:12, 2022
The E46K mutation modulates α-synuclein prion replication in transgenic mice.PLoS pathogens, , Volume: 18, Issue:12, 2022
Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:10, 2022
Alpha-Synuclein Autoimmune Decline in Prodromal Multiple System Atrophy and Parkinson's Disease.International journal of molecular sciences, , Jun-12, Volume: 23, Issue:12, 2022
COQ2 and SNCA polymorphisms interact with environmental factors to modulate the risk of multiple system atrophy and subtype disposition.European journal of neurology, , Volume: 29, Issue:10, 2022
Pathological substrate of memory impairment in multiple system atrophy.Neuropathology and applied neurobiology, , Volume: 48, Issue:7, 2022
Glutathione Depletion and MicroRNA Dysregulation in Multiple System Atrophy: A Review.International journal of molecular sciences, , Dec-01, Volume: 23, Issue:23, 2022
Clinical correlations of cerebrospinal fluid biomarkers including neuron-glia 2 and neurofilament light chain in patients with multiple system atrophy.Parkinsonism & related disorders, , Volume: 102, 2022
Aggregated Alpha-Synuclein Inclusions within the Nucleus Predict Impending Neuronal Cell Death in a Mouse Model of Parkinsonism.International journal of molecular sciences, , Dec-04, Volume: 23, Issue:23, 2022
α-Synuclein Seed Amplification Assays for Diagnosing Synucleinopathies: The Way Forward.Neurology, , 08-02, Volume: 99, Issue:5, 2022
Quaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein.Communications biology, , 09-30, Volume: 5, Issue:1, 2022
Involvement of autophagic protein DEF8 in Lewy bodies.Biochemical and biophysical research communications, , 10-01, Volume: 623, 2022
Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders.Acta neuropathologica communications, , 11-12, Volume: 10, Issue:1, 2022
Phosphorylation of Tau at Threonine 231 in Patients With Multiple System Atrophy and in a Mouse Model.Journal of neuropathology and experimental neurology, , 10-18, Volume: 81, Issue:11, 2022
Alpha-synuclein Immunization Strategies for Synucleinopathies in Clinical Studies: A Biological Perspective.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 19, Issue:5, 2022
Multiple system atrophy: α-Synuclein strains at the neuron-oligodendrocyte crossroad.Molecular neurodegeneration, , 11-26, Volume: 17, Issue:1, 2022
Phosphorylated α-Synuclein Deposits in Cutaneous Nerves of Early Parkinsonism.Journal of Parkinson's disease, , Volume: 12, Issue:8, 2022
Diagnostic value of α-synuclein seeding amplification assays in α-synucleinopathies: A systematic review and meta-analysis.Parkinsonism & related disorders, , Volume: 104, 2022
Neurons with Cat's Eyes: A Synthetic Strain of α-Synuclein Fibrils Seeding Neuronal Intranuclear Inclusions.Biomolecules, , 03-11, Volume: 12, Issue:3, 2022
Parkinson's disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein-induced changes in maturation and immune reactive properties.Proceedings of the National Academy of Sciences of the United States of America, , 03-22, Volume: 119, Issue:12, 2022
Brain injections of glial cytoplasmic inclusions induce a multiple system atrophy-like pathology.Brain : a journal of neurology, , 04-29, Volume: 145, Issue:3, 2022
Diagnostic Value of Salivary Real-Time Quaking-Induced Conversion in Parkinson's Disease and Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:5, 2022
Cardiac Alpha-Synuclein Is Present in Alpha-Synucleinopathies.Journal of Parkinson's disease, , Volume: 12, Issue:4, 2022
Synuclein-One study: skin biopsy detection of phosphorylated α-synuclein for diagnosis of synucleinopathies.Biomarkers in medicine, , Volume: 16, Issue:7, 2022
Pathological Relevance of Post-Translationally Modified Alpha-Synuclein (pSer87, pSer129, nTyr39) in Idiopathic Parkinson's Disease and Multiple System Atrophy.Cells, , 03-06, Volume: 11, Issue:5, 2022
Current Progress in the Development of Probes for Targeting α-Synuclein Aggregates.ACS chemical neuroscience, , 03-02, Volume: 13, Issue:5, 2022
In vivo imaging of alpha-synuclein with antibody-based PET.Neuropharmacology, , 05-01, Volume: 208, 2022
Fluid markers of synapse degeneration in synucleinopathies.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 129, Issue:2, 2022
Upregulation of α-synuclein following immune activation: Possible trigger of Parkinson's disease.Neurobiology of disease, , Volume: 166, 2022
Alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy.Translational neurodegeneration, , 02-07, Volume: 11, Issue:1, 2022
Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy.Proceedings of the National Academy of Sciences of the United States of America, , 02-08, Volume: 119, Issue:6, 2022
Impaired Sphingolipid Hydrolase Activities in Dementia with Lewy Bodies and Multiple System Atrophy.Molecular neurobiology, , Volume: 59, Issue:4, 2022
Infectious Agents as Potential Drivers of α-Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:3, 2022
mTOR Inhibition with Sirolimus in Multiple System Atrophy: A Randomized, Double-Blind, Placebo-Controlled Futility Trial and 1-Year Biomarker Longitudinal Analysis.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:4, 2022
Combining Skin α-Synuclein Real-Time Quaking-Induced Conversion and Circulating Neurofilament Light Chain to Distinguish Multiple System Atrophy and Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:3, 2022
Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies.Brain : a journal of neurology, , 04-18, Volume: 145, Issue:2, 2022
Long-standing multiple system atrophy-Parkinsonism with limbic and FTLD-type α-synuclein pathology.Neuropathology and applied neurobiology, , Volume: 48, Issue:3, 2022
The role of cardiovascular autonomic failure in the differential diagnosis of α-synucleinopathies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 43, Issue:1, 2022
Multiple system atrophy variant with severe hippocampal pathology.Brain pathology (Zurich, Switzerland), , Volume: 32, Issue:1, 2022
The Compound ATH434 Prevents Alpha-Synuclein Toxicity in a Murine Model of Multiple System Atrophy.Journal of Parkinson's disease, , Volume: 12, Issue:1, 2022
Electron Microscopic Analysis of α-Synuclein Fibrils.Methods in molecular biology (Clifton, N.J.), , Volume: 2322, 2021
A historical review of multiple system atrophy with a critical appraisal of cellular and animal models.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 128, Issue:10, 2021
Diagnostic utility of fluid biomarkers in multiple system atrophy: a systematic review and meta-analysis.Journal of neurology, , Volume: 268, Issue:8, 2021
Phosphorylated α-synuclein and phosphorylated tau-protein in sural nerves may contribute to differentiate Parkinson's disease from multiple system atrophy and progressive supranuclear paralysis.Neuroscience letters, , 06-21, Volume: 756, 2021
Cerebrospinal fluid and plasma distribution of anti-α-synuclein IgMs and IgGs in multiple system atrophy and Parkinson's disease.Parkinsonism & related disorders, , Volume: 87, 2021
Shared Genetics of Multiple System Atrophy and Inflammatory Bowel Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:2, 2021
Is Multiple System Atrophy a Prion-like Disorder?International journal of molecular sciences, , Sep-18, Volume: 22, Issue:18, 2021
α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson's disease from multiple system atrophy.Acta neuropathologica, , Volume: 142, Issue:3, 2021
Dermal and cardiac autonomic fiber involvement in Parkinson's disease and multiple system atrophy.Neurobiology of disease, , Volume: 153, 2021
Therapeutic potential of iron modulating drugs in a mouse model of multiple system atrophy.Neurobiology of disease, , Volume: 159, 2021
Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential.Acta neuropathologica, , Volume: 142, Issue:1, 2021
Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo.Nature communications, , 09-10, Volume: 12, Issue:1, 2021
Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple system atrophy.Acta neuropathologica communications, , 05-03, Volume: 9, Issue:1, 2021
Seeded assembly in vitro does not replicate the structures of α-synuclein filaments from multiple system atrophy.FEBS open bio, , Volume: 11, Issue:4, 2021
Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy.Journal of cellular and molecular medicine, , Volume: 25, Issue:20, 2021
Phytochemicals as Regulators of Genes Involved in Synucleinopathies.Biomolecules, , 04-22, Volume: 11, Issue:5, 2021
Alpha-Synuclein Oligomers and Neurofilament Light Chain Predict Phenoconversion of Pure Autonomic Failure.Annals of neurology, , Volume: 89, Issue:6, 2021
Investigating ELOVL7 coding variants in multiple system atrophy.Neuroscience letters, , 04-01, Volume: 749, 2021
In situ architecture of neuronal α-Synuclein inclusions.Nature communications, , 04-14, Volume: 12, Issue:1, 2021
Human alpha-synuclein overexpressing MBP29 mice mimic functional and structural hallmarks of the cerebellar subtype of multiple system atrophy.Acta neuropathologica communications, , 04-14, Volume: 9, Issue:1, 2021
Viral-based rodent and nonhuman primate models of multiple system atrophy: Fidelity to the human disease.Neurobiology of disease, , Volume: 148, 2021
RT-QUiC in multiple system atrophy: the biomarker of the future? and other updates on recent autonomic research.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 31, Issue:1, 2021
In Vivo Diagnosis of Synucleinopathies: A Comparative Study of Skin Biopsy and RT-QuIC.Neurology, , 05-18, Volume: 96, Issue:20, 2021
MOBP and HIP1 in multiple system atrophy: New α-synuclein partners in glial cytoplasmic inclusions implicated in the disease pathogenesis.Neuropathology and applied neurobiology, , Volume: 47, Issue:5, 2021
Inflammation in Experimental Models of α-Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:1, 2021
Signs of early cellular dysfunction in multiple system atrophy.Neuropathology and applied neurobiology, , Volume: 47, Issue:2, 2021
Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies.Acta neuropathologica communications, , 08-28, Volume: 9, Issue:1, 2021
Current experimental disease-modifying therapeutics for multiple system atrophy.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 128, Issue:10, 2021
[Non-motor symptoms of Parkinson's disease from pathophysiology to early diagnosis].La Revue de medecine interne, , Volume: 42, Issue:4, 2021
Systematic Assessment of 10 Biomarker Candidates Focusing on α-Synuclein-Related Disorders.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:12, 2021
The Alpha-Synuclein RT-QuIC Products Generated by the Olfactory Mucosa of Patients with Parkinson's Disease and Multiple System Atrophy Induce Inflammatory Responses in SH-SY5Y Cells.Cells, , 12-28, Volume: 11, Issue:1, 2021
Neuropathology of multiple system atrophy: Kurt Jellinger`s legacy.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 128, Issue:10, 2021
Neuropathology and molecular diagnosis of Synucleinopathies.Molecular neurodegeneration, , 12-18, Volume: 16, Issue:1, 2021
Discrimination of MSA-P and MSA-C by RT-QuIC analysis of olfactory mucosa: the first assessment of assay reproducibility between two specialized laboratories.Molecular neurodegeneration, , 12-11, Volume: 16, Issue:1, 2021
Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds.Acta neuropathologica communications, , 11-24, Volume: 9, Issue:1, 2021
ATH434 Reduces α-Synuclein-Related Neurodegeneration in a Murine Model of Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:11, 2021
Role of VAPB and vesicular profiles in α-synuclein aggregates in multiple system atrophy.Brain pathology (Zurich, Switzerland), , Volume: 31, Issue:6, 2021
Phenotypic manifestation of α-synuclein strains derived from Parkinson's disease and multiple system atrophy in human dopaminergic neurons.Nature communications, , 06-21, Volume: 12, Issue:1, 2021
Structural and Functional Insights into α-Synuclein Fibril Polymorphism.Biomolecules, , 09-28, Volume: 11, Issue:10, 2021
The good and bad of therapeutic strategies that directly target α-synuclein.IUBMB life, , Volume: 72, Issue:4, 2020
Synuclein in red blood cells: a potential biomarker for multiple system atrophy, and other updates on recent autonomic research.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 30, Issue:2, 2020
Analysis of Protein Conformational Strains-A Key for New Diagnostic Methods of Human Diseases.International journal of molecular sciences, , Apr-17, Volume: 21, Issue:8, 2020
Current Symptomatic and Disease-Modifying Treatments in Multiple System Atrophy.International journal of molecular sciences, , Apr-16, Volume: 21, Issue:8, 2020
Comparison of 123I-MIBG scintigraphy and phosphorylated α-synuclein skin deposits in synucleinopathies.Parkinsonism & related disorders, , Volume: 81, 2020
Nilotinib Fails to Prevent Synucleinopathy and Cell Loss in a Mouse Model of Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:7, 2020
Synthesis and characterization of high affinity fluorogenic α-synuclein probes.Chemical communications (Cambridge, England), , Mar-24, Volume: 56, Issue:24, 2020
Insights into the pathogenesis of multiple system atrophy: focus on glial cytoplasmic inclusions.Translational neurodegeneration, , Volume: 9, 2020
Phenotypic Heterogeneity in α-Synucleinopathies: Straining the Difference.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:4, 2020
Multiplicity of α-Synuclein Aggregated Species and Their Possible Roles in Disease.International journal of molecular sciences, , Oct-28, Volume: 21, Issue:21, 2020
Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy.Cells, , 10-29, Volume: 9, Issue:11, 2020
Conjugal multiple system atrophy: Computing chance or investigating real patients?Parkinsonism & related disorders, , Volume: 75, 2020
Neurodegenerative diseases distinguished through protein-structure analysis.Nature, , Volume: 578, Issue:7794, 2020
[REM Sleep Behavior Disorder and α-synucleinopathy].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:2, 2020
Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy.Nature, , Volume: 578, Issue:7794, 2020
FTY720-Mitoxy reduces synucleinopathy and neuroinflammation, restores behavior and mitochondria function, and increases GDNF expression in Multiple System Atrophy mouse models.Experimental neurology, , Volume: 325, 2020
Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophy.PLoS pathogens, , Volume: 16, Issue:2, 2020
Novel antibodies detect additional α-synuclein pathology in synucleinopathies: potential development for immunotherapy.Alzheimer's research & therapy, , 11-30, Volume: 12, Issue:1, 2020
High-salt diet does not boost neuroinflammation and neurodegeneration in a model of α-synucleinopathy.Journal of neuroinflammation, , Jan-24, Volume: 17, Issue:1, 2020
Disease-Specific Strains of α-Synuclein in Multiple System Atrophy and Parkinson's Disease: But Why?Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:5, 2020
White matter DNA methylation profiling reveals deregulation of HIP1, LMAN2, MOBP, and other loci in multiple system atrophy.Acta neuropathologica, , Volume: 139, Issue:1, 2020
Conjugal multiple system atrophy: Be wary of implicating transmissibility.Parkinsonism & related disorders, , Volume: 75, 2020
Targeting α-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance.Translational neurodegeneration, , 09-24, Volume: 9, Issue:1, 2020
A Phase 1 Randomized Trial of Specific Active α-Synuclein Immunotherapies PD01A and PD03A in Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:11, 2020
Conjugal multiple system atrophy: Rethinking numbers of probability.Parkinsonism & related disorders, , Volume: 77, 2020
Current Management and Emerging Therapies in Multiple System Atrophy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 17, Issue:4, 2020
BCAS1-positive immature oligodendrocytes are affected by the α-synuclein-induced pathology of multiple system atrophy.Acta neuropathologica communications, , 07-29, Volume: 8, Issue:1, 2020
Somatic mutations in neurodegeneration: An update.Neurobiology of disease, , Volume: 144, 2020
Cerebral white matter tau-positive granular glial pathology as a characteristic pathological feature in long survivors of multiple system atrophy.Journal of the neurological sciences, , 09-15, Volume: 416, 2020
Skin Biopsy May Help to Distinguish Multiple System Atrophy-Parkinsonism from Parkinson's Disease With Orthostatic Hypotension.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:9, 2020
Alpha-Synuclein Oligomers and Neurofilament Light Chain in Spinal Fluid Differentiate Multiple System Atrophy from Lewy Body Synucleinopathies.Annals of neurology, , Volume: 88, Issue:3, 2020
Structures of α-synuclein filaments from multiple system atrophy.Nature, , Volume: 585, Issue:7825, 2020
Reduced oligodendrocyte exosome secretion in multiple system atrophy involves SNARE dysfunction.Brain : a journal of neurology, , 06-01, Volume: 143, Issue:6, 2020
Hippocampal α-synuclein pathology correlates with memory impairment in multiple system atrophy.Brain : a journal of neurology, , 06-01, Volume: 143, Issue:6, 2020
The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson's disease, multiple system atrophy and dementia with Lewy bodies.Acta neuropathologica, , Volume: 139, Issue:6, 2020
Lower Vitamin B12 Level at Multiple System Atrophy Diagnosis Is Associated With Shorter Survival.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:8, 2020
Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines.Acta neuropathologica, , Volume: 137, Issue:3, 2019
Comparative analyses of the in vivo induction and transmission of α-synuclein pathology in transgenic mice by MSA brain lysate and recombinant α-synuclein fibrils.Acta neuropathologica communications, , 05-20, Volume: 7, Issue:1, 2019
Alpha-synuclein in erythrocyte membrane of patients with multiple system atrophy: A pilot study.Parkinsonism & related disorders, , Volume: 60, 2019
Understanding the pathogenesis of multiple system atrophy: state of the art and future perspectives.Acta neuropathologica communications, , 07-12, Volume: 7, Issue:1, 2019
Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human α-synuclein.Acta neuropathologica communications, , 05-20, Volume: 7, Issue:1, 2019
Distinct Autoimmune Anti-α-Synuclein Antibody Patterns in Multiple System Atrophy and Parkinson's Disease.Frontiers in immunology, , Volume: 10, 2019
Abnormal α-synuclein deposits in skin nerves: intra- and inter-laboratory reproducibility.European journal of neurology, , Volume: 26, Issue:10, 2019
"Minimal change" multiple system atrophy with limbic-predominant α-synuclein pathology.Acta neuropathologica, , Volume: 137, Issue:1, 2019
Shrinkage of the myenteric neurons of the small intestine in patients with multiple system atrophy.Autonomic neuroscience : basic & clinical, , Volume: 221, 2019
The heart of PD: Lewy body diseases as neurocardiologic disorders.Brain research, , 01-01, Volume: 1702, 2019
Abundance of Synaptic Vesicle-Related Proteins in Alpha-Synuclein-Containing Protein Inclusions Suggests a Targeted Formation Mechanism.Neurotoxicity research, , Volume: 35, Issue:4, 2019
TIGAR inclusion pathology is specific for Lewy body diseases.Brain research, , 03-01, Volume: 1706, 2019
Parkinson's disease and multiple system atrophy have distinct α-synuclein seed characteristics.The Journal of biological chemistry, , 01-18, Volume: 294, Issue:3, 2019
Wide distribution of alpha-synuclein oligomers in multiple system atrophy brain detected by proximity ligation.Acta neuropathologica, , Volume: 137, Issue:3, 2019
Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid - method comparison and round robin study.Journal of neurochemistry, , Volume: 149, Issue:1, 2019
Stabilization of α-synuclein oligomers using formaldehyde.PloS one, , Volume: 14, Issue:10, 2019
The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy.Biochimica et biophysica acta. Molecular basis of disease, , 11-01, Volume: 1865, Issue:11, 2019
A mouse model of adult-onset multiple system atrophy.Neurobiology of disease, , Volume: 127, 2019
Cross-examining candidate genes implicated in multiple system atrophy.Acta neuropathologica communications, , 07-24, Volume: 7, Issue:1, 2019
Progressive supranuclear palsy, multiple system atrophy and corticobasal degeneration.Handbook of clinical neurology, , Volume: 165, 2019
Investigation of somatic CNVs in brains of synucleinopathy cases using targeted SNCA analysis and single cell sequencing.Acta neuropathologica communications, , 12-23, Volume: 7, Issue:1, 2019
Silver staining (Campbell-Switzer) of neuronal α-synuclein assemblies induced by multiple system atrophy and Parkinson's disease brain extracts in transgenic mice.Acta neuropathologica communications, , 09-16, Volume: 7, Issue:1, 2019
Dissecting α-synuclein inclusion pathology diversity in multiple system atrophy: implications for the prion-like transmission hypothesis.Laboratory investigation; a journal of technical methods and pathology, , Volume: 99, Issue:7, 2019
Oligodendroglial α-synucleinopathy-driven neuroinflammation in multiple system atrophy.Brain pathology (Zurich, Switzerland), , Volume: 29, Issue:3, 2019
Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts.Nature communications, , 12-04, Volume: 10, Issue:1, 2019
Luminescent conjugated oligothiophenes distinguish between α-synuclein assemblies of Parkinson's disease and multiple system atrophy.Acta neuropathologica communications, , 12-03, Volume: 7, Issue:1, 2019
Alpha-synuclein structure and Parkinson's disease - lessons and emerging principles.Molecular neurodegeneration, , 07-22, Volume: 14, Issue:1, 2019
Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies.JCI insight, , 08-22, Volume: 4, Issue:16, 2019
Spinal cord α-synuclein deposition associated with myoclonus in patients with MSA-C.Neurology, , 08-13, Volume: 93, Issue:7, 2019
Multiple system atrophy and myoclonus: A morphologic marker in the spinal cord?Neurology, , 08-13, Volume: 93, Issue:7, 2019
Moving forward the in vivo diagnosis of the synucleinopathies.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 29, Issue:6, 2019
Anle138b modulates α-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:2, 2019
Living in Promiscuity: The Multiple Partners of Alpha-Synuclein at the Synapse in Physiology and Pathology.International journal of molecular sciences, , Jan-02, Volume: 20, Issue:1, 2019
FTY720-Mitoxy reduces toxicity associated with MSA-like α-synuclein and oxidative stress by increasing trophic factor expression and myelin protein in OLN-93 oligodendroglia cell cultures.Neuropharmacology, , 11-01, Volume: 158, 2019
Binding of α-synuclein oligomers to Cx32 facilitates protein uptake and transfer in neurons and oligodendrocytes.Acta neuropathologica, , Volume: 138, Issue:1, 2019
Phosphorylated NUB1 distinguishes α-synuclein in Lewy bodies from that in glial cytoplasmic inclusions in multiple system atrophy.Brain pathology (Zurich, Switzerland), , Volume: 29, Issue:6, 2019
Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models.Acta neuropathologica, , Volume: 138, Issue:3, 2019
Coexisting Lewy body disease and clinical parkinsonism in frontotemporal lobar degeneration.Neurology, , 05-21, Volume: 92, Issue:21, 2019
Cerebral mitochondrial electron transport chain dysfunction in multiple system atrophy and Parkinson's disease.Scientific reports, , 04-25, Volume: 9, Issue:1, 2019
Detecting Alpha Synuclein Seeding Activity in Formaldehyde-Fixed MSA Patient Tissue by PMCA.Molecular neurobiology, , Volume: 55, Issue:11, 2018
Rapid eye movement sleep behavior disorder and the link to alpha-synucleinopathies.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, , Volume: 129, Issue:8, 2018
Multiple system atrophy and apolipoprotein E.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:4, 2018
TDP-43 pathology in multiple system atrophy: colocalization of TDP-43 and α-synuclein in glial cytoplasmic inclusions.Neuropathology and applied neurobiology, , Volume: 44, Issue:7, 2018
FKBP12-immunopositive inclusions in patients with α-synucleinopathies.Brain research, , 02-01, Volume: 1680, 2018
Is multiple system atrophy an infectious disease?Annals of neurology, , Volume: 83, Issue:1, 2018
Familial Parkinson's point mutation abolishes multiple system atrophy prion replication.Proceedings of the National Academy of Sciences of the United States of America, , 01-09, Volume: 115, Issue:2, 2018
Translational therapies for multiple system atrophy: Bottlenecks and future directions.Autonomic neuroscience : basic & clinical, , Volume: 211, 2018
Recent advances in neuropathology, biomarkers and therapeutic approach of multiple system atrophy.Journal of neurology, neurosurgery, and psychiatry, , Volume: 89, Issue:2, 2018
Key themes and future prospects in translational multiple system atrophy research.Autonomic neuroscience : basic & clinical, , Volume: 211, 2018
The Relevance of Iron in the Pathogenesis of Multiple System Atrophy: A Viewpoint.Journal of Alzheimer's disease : JAD, , Volume: 61, Issue:4, 2018
Alpha-synuclein levels in patients with multiple system atrophy: a meta-analysis.The International journal of neuroscience, , Volume: 128, Issue:5, 2018
Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods.Acta neuropathologica communications, , 04-18, Volume: 6, Issue:1, 2018
α-Synuclein strains in multiple system atrophy: A product of their environment?Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:8, 2018
The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson's disease.Scientific reports, , 11-01, Volume: 8, Issue:1, 2018
Extracellular Interactions of Alpha-Synuclein in Multiple System Atrophy.International journal of molecular sciences, , Dec-19, Volume: 19, Issue:12, 2018
Present and future of disease-modifying therapies in multiple system atrophy.Autonomic neuroscience : basic & clinical, , Volume: 211, 2018
Progressive striatonigral degeneration in a transgenic mouse model of multiple system atrophy: translational implications for interventional therapies.Acta neuropathologica communications, , 01-03, Volume: 6, Issue:1, 2018
ɑ-Synuclein strains and seeding in Parkinson's disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences.Cell and tissue research, , Volume: 373, Issue:1, 2018
Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy.Stem cell reports, , 02-13, Volume: 10, Issue:2, 2018
α-Synuclein: Multiple System Atrophy Prions.Cold Spring Harbor perspectives in medicine, , 07-02, Volume: 8, Issue:7, 2018
Converging Patterns of α-Synuclein Pathology in Multiple System Atrophy.Journal of neuropathology and experimental neurology, , 11-01, Volume: 77, Issue:11, 2018
The neuropathology of multiple system atrophy and its therapeutic implications.Autonomic neuroscience : basic & clinical, , Volume: 211, 2018
NLRP3 Inflammasome-Related Proteins Are Upregulated in the Putamen of Patients With Multiple System Atrophy.Journal of neuropathology and experimental neurology, , 11-01, Volume: 77, Issue:11, 2018
Somatic copy number gains of α-synuclein (SNCA) in Parkinson's disease and multiple system atrophy brains.Brain : a journal of neurology, , 08-01, Volume: 141, Issue:8, 2018
MSA prions exhibit remarkable stability and resistance to inactivation.Acta neuropathologica, , Volume: 135, Issue:1, 2018
Skin α-synuclein deposits differ in clinical variants of synucleinopathy: an in vivo study.Scientific reports, , 09-24, Volume: 8, Issue:1, 2018
Epothilone D inhibits microglia-mediated spread of alpha-synuclein aggregates.Molecular and cellular neurosciences, , Volume: 89, 2018
Amyloid-Beta Radiotracer [Contrast media & molecular imaging, , Volume: 2018, 2018
Multiple System Atrophy: An Oligodendroglioneural Synucleinopathy1.Journal of Alzheimer's disease : JAD, , Volume: 62, Issue:3, 2018
Limited effects of dysfunctional macroautophagy on the accumulation of extracellularly derived α-synuclein in oligodendroglia: implications for MSA pathogenesis.BMC neuroscience, , 05-21, Volume: 19, Issue:1, 2018
LRRK2 p.Ile1371Val Mutation in a Case with Neuropathologically Confirmed Multi-System Atrophy.Journal of Parkinson's disease, , Volume: 8, Issue:1, 2018
Investigating the neuroprotective effect of AAV-mediated β-synuclein overexpression in a transgenic model of synucleinopathy.Scientific reports, , 12-03, Volume: 8, Issue:1, 2018
Genetics of Synucleinopathies.Cold Spring Harbor perspectives in medicine, , 06-01, Volume: 8, Issue:6, 2018
When Do α-Synucleinopathies Start? An Epidemiological Timeline: A Review.JAMA neurology, , 04-01, Volume: 75, Issue:4, 2018
Lysosomal response in relation to α-synuclein pathology differs between Parkinson's disease and multiple system atrophy.Neurobiology of disease, , Volume: 114, 2018
Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated.Brain : a journal of neurology, , 07-01, Volume: 141, Issue:7, 2018
AMBRA1, a novel α-synuclein-binding protein, is implicated in the pathogenesis of multiple system atrophy.Brain pathology (Zurich, Switzerland), , Volume: 28, Issue:1, 2018
Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy.Molecular neurodegeneration, , 07-04, Volume: 12, Issue:1, 2017
Therapeutic approaches to target alpha-synuclein pathology.Experimental neurology, , Volume: 298, Issue:Pt B, 2017
Survival and Causes of Death Among People With Clinically Diagnosed Synucleinopathies With Parkinsonism: A Population-Based Study.JAMA neurology, , 07-01, Volume: 74, Issue:7, 2017
α-synuclein astrogliopathy: A possible specific feature in α-synucleinopathy.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 37, Issue:4, 2017
Viral-mediated oligodendroglial alpha-synuclein expression models multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:8, 2017
Brain monoamine oxidase B and A in human parkinsonian dopamine deficiency disorders.Brain : a journal of neurology, , Sep-01, Volume: 140, Issue:9, 2017
Autoimmune antibody decline in Parkinson's disease and Multiple System Atrophy; a step towards immunotherapeutic strategies.Molecular neurodegeneration, , 06-07, Volume: 12, Issue:1, 2017
Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates.Acta neuropathologica communications, , 06-16, Volume: 5, Issue:1, 2017
Increased aneuploidy is not a universal feature across α-synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:3, 2017
Potential Modes of Intercellular α-Synuclein Transmission.International journal of molecular sciences, , Feb-22, Volume: 18, Issue:2, 2017
Analysis of the prion protein gene in multiple system atrophy.Neurobiology of aging, , Volume: 49, 2017
α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies.Nature medicine, , Feb-07, Volume: 23, Issue:2, 2017
Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid.JAMA neurology, , Feb-01, Volume: 74, Issue:2, 2017
Profile of cognitive impairment and underlying pathology in multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:3, 2017
Synucleinopathies: common features and hippocampal manifestations.Cellular and molecular life sciences : CMLS, , Volume: 74, Issue:8, 2017
Progression of alpha-synuclein pathology in multiple system atrophy of the cerebellar type.Neuropathology and applied neurobiology, , Volume: 43, Issue:4, 2017
Fluorescence and autoradiographic evaluation of tau PET ligand PBB3 to α-synuclein pathology.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:6, 2017
Perirhinal accumulation of neuronal alpha-synuclein in a multiple system atrophy patient with dementia.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 37, Issue:5, 2017
The Synucleinopathies: Twenty Years On.Journal of Parkinson's disease, , Volume: 7, Issue:s1, 2017
Insulin resistance and exendin-4 treatment for multiple system atrophy.Brain : a journal of neurology, , May-01, Volume: 140, Issue:5, 2017
Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy.Acta neuropathologica communications, , 01-05, Volume: 5, Issue:1, 2017
Medullary neuronal loss is not associated with α-synuclein burden in multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:12, 2016
A genome-wide association study in multiple system atrophy.Neurology, , Oct-11, Volume: 87, Issue:15, 2016
Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril.Scientific reports, , 08-04, Volume: 6, 2016
Changes in the miRNA-mRNA Regulatory Network Precede Motor Symptoms in a Mouse Model of Multiple System Atrophy: Clinical Implications.PloS one, , Volume: 11, Issue:3, 2016
α-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy.Acta neuropathologica, , Volume: 132, Issue:1, 2016
Active immunization therapies for Parkinson's disease and multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Neuroprotection by Epigenetic Modulation in a Transgenic Model of Multiple System Atrophy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 13, Issue:4, 2016
Reply: Skin biopsies in the differential diagnosis of parkinsonism: are we ready for simplified protocols?Brain : a journal of neurology, , Volume: 139, Issue:Pt 1, 2016
Is Multiple System Atrophy a New Prion Disorder?Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:3, 2016
Skin biopsies in the differential diagnosis of parkinsonism: are we ready for simplified protocols?Brain : a journal of neurology, , Volume: 139, Issue:Pt 1, 2016
Preface.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Animal modeling an oligodendrogliopathy--multiple system atrophy.Acta neuropathologica communications, , Feb-09, Volume: 4, 2016
Accumulation of phosphorylated α-synuclein in subpial and periventricular astrocytes in multiple system atrophy of long duration.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 36, Issue:2, 2016
Diagnostic utility of CSF α-synuclein species in Parkinson's disease: protocol for a systematic review and meta-analysis.BMJ open, , 06-13, Volume: 6, Issue:6, 2016
α-Synuclein: Experimental Pathology.Cold Spring Harbor perspectives in medicine, , Sep-01, Volume: 6, Issue:9, 2016
Imaging synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:6, 2016
FBXO7 mutations in Parkinson's disease and multiple system atrophy.Neurobiology of aging, , Volume: 40, 2016
Strand-specific RNA-sequencing analysis of multiple system atrophy brain transcriptome.Neuroscience, , May-13, Volume: 322, 2016
Mesenchymal stem cells enhance α-synuclein clearance via M2 microglia polarization in experimental and human parkinsonian disorder.Acta neuropathologica, , Volume: 132, Issue:5, 2016
Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?Journal of Parkinson's disease, , Volume: 6, Issue:1, 2016
ɑ-Synuclein strains and the variable pathologies of synucleinopathies.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Overlaps between multiple system atrophy and multiple sclerosis: A novel perspective.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:12, 2016
Review: Novel treatment strategies targeting alpha-synuclein in multiple system atrophy as a model of synucleinopathy.Neuropathology and applied neurobiology, , Volume: 42, Issue:1, 2016
'Under pressure': is there a link between orthostatic hypotension and cognitive impairment in α-synucleinopathies?Journal of neurology, neurosurgery, and psychiatry, , Volume: 87, Issue:12, 2016
Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy.Proceedings of the National Academy of Sciences of the United States of America, , 08-23, Volume: 113, Issue:34, 2016
Up-regulation of SNCA gene expression: implications to synucleinopathies.Neurogenetics, , Volume: 17, Issue:3, 2016
MAPT haplotype diversity in multiple system atrophy.Parkinsonism & related disorders, , Volume: 30, 2016
Review: Multiple system atrophy: emerging targets for interventional therapies.Neuropathology and applied neurobiology, , Volume: 42, Issue:1, 2016
Review: The spectrum of clinical features seen with alpha synuclein pathology.Neuropathology and applied neurobiology, , Volume: 42, Issue:1, 2016
Therapeutic approaches in Parkinson's disease and related disorders.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Development of Passive Immunotherapies for Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Alpha-synuclein in gastric and colonic mucosa in Parkinson's disease: Limited role as a biomarker.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Review: Spreading the word: precise animal models and validated methods are vital when evaluating prion-like behaviour of alpha-synuclein.Neuropathology and applied neurobiology, , Volume: 42, Issue:1, 2016
Altered α-synuclein, parkin, and synphilin isoform levels in multiple system atrophy brains.Journal of neurochemistry, , Volume: 136, Issue:1, 2016
Combination therapies: The next logical Step for the treatment of synucleinopathies?Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.Proceedings of the National Academy of Sciences of the United States of America, , Sep-22, Volume: 112, Issue:38, 2015
Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation.Molecular neurodegeneration, , Aug-27, Volume: 10, 2015
Putative neuropathological interactions in MSA: focus in the rostral ventrolateral medulla.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 25, Issue:1, 2015
Region-Specific Alterations of Matrix Metalloproteinase Activity in Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:13, 2015
Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy.Molecular neurodegeneration, , Mar-19, Volume: 10, 2015
Atypical multiple system atrophy is a new subtype of frontotemporal lobar degeneration: frontotemporal lobar degeneration associated with α-synuclein.Acta neuropathologica, , Volume: 130, Issue:1, 2015
SNP rs11931074 of the SNCA gene may not be associated with multiple system atrophy in Chinese population.The International journal of neuroscience, , Volume: 125, Issue:8, 2015
The degree of astrocyte activation in multiple system atrophy is inversely proportional to the distance to α-synuclein inclusions.Molecular and cellular neurosciences, , Volume: 65, 2015
α-Synuclein pathology accumulates in sacral spinal visceral sensory pathways.Annals of neurology, , Volume: 78, Issue:1, 2015
Mitochondrial impairment and oxidative stress compromise autophagosomal degradation of α-synuclein in oligodendroglial cells.Journal of neurochemistry, , Volume: 135, Issue:1, 2015
Role for the microtubule-associated protein tau variant p.A152T in risk of α-synucleinopathies.Neurology, , Nov-10, Volume: 85, Issue:19, 2015
Role of transcriptional control in multiple system atrophy.Neurobiology of aging, , Volume: 36, Issue:1, 2015
Genetic Variants of SNCA Are Associated with Susceptibility to Parkinson's Disease but Not Amyotrophic Lateral Sclerosis or Multiple System Atrophy in a Chinese Population.PloS one, , Volume: 10, Issue:7, 2015
Peripheral synuclein tissue markers: a step closer to Parkinson's disease diagnosis.Brain : a journal of neurology, , Volume: 138, Issue:Pt 8, 2015
α-Synuclein strains cause distinct synucleinopathies after local and systemic administration.Nature, , Jun-18, Volume: 522, Issue:7556, 2015
Multiple system atrophy: the application of genetics in understanding etiology.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 25, Issue:1, 2015
Animal models of multiple system atrophy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 25, Issue:1, 2015
Failure of Neuroprotection Despite Microglial Suppression by Delayed-Start Myeloperoxidase Inhibition in a Model of Advanced Multiple System Atrophy: Clinical Implications.Neurotoxicity research, , Volume: 28, Issue:3, 2015
Expanding the prion disease repertoire.Proceedings of the National Academy of Sciences of the United States of America, , Sep-22, Volume: 112, Issue:38, 2015
Neurodegeneration: Aggregates feel the strain.Nature, , Jun-18, Volume: 522, Issue:7556, 2015
Distinctive distribution of phospho-alpha-synuclein in dermal nerves in multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:12, 2015
Novel therapeutic approaches in multiple system atrophy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 25, Issue:1, 2015
Parkinson disease: Disease-linked morphometric variants of α-synuclein.Nature reviews. Neurology, , Volume: 11, Issue:8, 2015
Filamentous aggregations of phosphorylated α-synuclein in Schwann cells (Schwann cell cytoplasmic inclusions) in multiple system atrophy.Acta neuropathologica communications, , May-21, Volume: 3, 2015
Models of multiple system atrophy.Current topics in behavioral neurosciences, , Volume: 22, 2015
Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative.Neurobiology of disease, , Volume: 80, 2015
Expanding the spectrum of neuronal pathology in multiple system atrophy.Brain : a journal of neurology, , Volume: 138, Issue:Pt 8, 2015
Phosphorylated α-synuclein in skin nerve fibres differentiates Parkinson's disease from multiple system atrophy.Brain : a journal of neurology, , Volume: 138, Issue:Pt 8, 2015
Screening for α-synuclein immunoreactive neuronal inclusions in the hippocampus allows identification of atypical MSA (FTLD-synuclein).Acta neuropathologica, , Volume: 130, Issue:2, 2015
Minimal change multiple system atrophy: an aggressive variant?Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:7, 2015
Use of CSF α-synuclein in the differential diagnosis between Alzheimer's disease and other neurodegenerative disorders.International psychogeriatrics, , Volume: 27, Issue:9, 2015
Transcriptome analysis of grey and white matter cortical tissue in multiple system atrophy.Neurogenetics, , Volume: 16, Issue:2, 2015
Parkinson's disease and prion disease: Straining the comparison.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:13, 2015
Overexpression of α-synuclein in oligodendrocytes does not increase susceptibility to focal striatal excitotoxicity.BMC neuroscience, , Dec-02, Volume: 16, 2015
Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein.Acta neuropathologica communications, , Nov-26, Volume: 3, 2015
Involvement of Peripheral Nerves in the Transgenic PLP-α-Syn Model of Multiple System Atrophy: Extending the Phenotype.PloS one, , Volume: 10, Issue:10, 2015
Survival in synucleinopathies: A prospective cohort study.Neurology, , Nov-03, Volume: 85, Issue:18, 2015
A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy.Molecular neurodegeneration, , Sep-23, Volume: 10, 2015
Evidence piles Up for prion-like propagation mechanisms in synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:2, 2014
Age-related motor dysfunction and neuropathology in a transgenic mouse model of multiple system atrophy.Synapse (New York, N.Y.), , Volume: 68, Issue:3, 2014
α-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy.Neurobiology of aging, , Volume: 35, Issue:10, 2014
Novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology.Neurobiology of aging, , Volume: 35, Issue:9, 2014
Altered lipid levels provide evidence for myelin dysfunction in multiple system atrophy.Acta neuropathologica communications, , Oct-29, Volume: 2, 2014
β-III Tubulin fragments inhibit α-synuclein accumulation in models of multiple system atrophy.The Journal of biological chemistry, , Aug-29, Volume: 289, Issue:35, 2014
Update on novel familial forms of Parkinson's disease and multiple system atrophy.Parkinsonism & related disorders, , Volume: 20 Suppl 1, 2014
Immunohistochemical localization of spatacsin in α-synucleinopathies.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 34, Issue:2, 2014
Increase of the plasma α-synuclein levels in patients with multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:3, 2014
Multiple system atrophy: a prototypical synucleinopathy for disease-modifying therapeutic strategies.Neurobiology of disease, , Volume: 67, 2014
α-Synucleinopathy phenotypes.Parkinsonism & related disorders, , Volume: 20 Suppl 1, 2014
Prodegenerative IκBα expression in oligodendroglial α-synuclein models of multiple system atrophy.Neurobiology of disease, , Volume: 63, 2014
[Clinical picture and diagnostic criteria of multiple system atrophy].Rinsho shinkeigaku = Clinical neurology, , Volume: 54, Issue:12, 2014
SNCA variants rs2736990 and rs356220 as risk factors for Parkinson's disease but not for amyotrophic lateral sclerosis and multiple system atrophy in a Chinese population.Neurobiology of aging, , Volume: 35, Issue:12, 2014
Antidepressants reduce neuroinflammatory responses and astroglial alpha-synuclein accumulation in a transgenic mouse model of multiple system atrophy.Glia, , Volume: 62, Issue:2, 2014
Degeneration of brainstem respiratory neurons in dementia with Lewy bodies.Sleep, , Feb-01, Volume: 37, Issue:2, 2014
Towards translational therapies for multiple system atrophy.Progress in neurobiology, , Volume: 118, 2014
CSF α-synuclein and UCH-L1 levels in Parkinson's disease and atypical parkinsonian disorders.Parkinsonism & related disorders, , Volume: 20, Issue:4, 2014
Alpha-synuclein mRNA expression in oligodendrocytes in MSA.Glia, , Volume: 62, Issue:6, 2014
Reduced alpha-synuclein in cerebrospinal fluid in synucleinopathies: evidence from a meta-analysis.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:13, 2014
Neuropathology of multiple system atrophy: new thoughts about pathogenesis.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:14, 2014
Cystatin C triggers neuronal degeneration in a model of multiple system atrophy.The American journal of pathology, , Volume: 184, Issue:3, 2014
Multiple system atrophy of the cerebellar type: clinical state of the art.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:3, 2014
Multiple system atrophy as emerging template for accelerated drug discovery in α-synucleinopathies.Parkinsonism & related disorders, , Volume: 20, Issue:8, 2014
The potential prognostic role of cardiovascular autonomic failure in α-synucleinopathies.European journal of neurology, , Volume: 20, Issue:2, 2013
Loss of DARPP-32 and calbindin in multiple system atrophy.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 120, Issue:12, 2013
Bladder dysfunction in a transgenic mouse model of multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:3, 2013
α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?Acta neuropathologica, , Volume: 125, Issue:5, 2013
Incidence and prevalence of multiple system atrophy: a nationwide study in Iceland.Journal of neurology, neurosurgery, and psychiatry, , Volume: 84, Issue:2, 2013
100 years of Lewy pathology.Nature reviews. Neurology, , Volume: 9, Issue:1, 2013
FBXO7 immunoreactivity in α-synuclein-containing inclusions in Parkinson disease and multiple system atrophy.Journal of neuropathology and experimental neurology, , Volume: 72, Issue:6, 2013
Differentiation of progressive supranuclear palsy: clinical, imaging and laboratory tools.Acta neurologica Scandinavica, , Volume: 127, Issue:5, 2013
Identification and quantification of oligodendrocyte precursor cells in multiple system atrophy, progressive supranuclear palsy and Parkinson's disease.Brain pathology (Zurich, Switzerland), , Volume: 23, Issue:3, 2013
Increased expression of ABCA8 in multiple system atrophy brain is associated with changes in pathogenic proteins.Journal of Parkinson's disease, , Jan-01, Volume: 3, Issue:3, 2013
Oligodendroglial alpha-synucleinopathy and MSA-like cardiovascular autonomic failure: experimental evidence.Experimental neurology, , Volume: 247, 2013
FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy.PloS one, , Volume: 8, Issue:1, 2013
The glial marker YKL-40 is decreased in synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:13, 2013
Submandibular gland biopsy for the diagnosis of Parkinson disease.Journal of neuropathology and experimental neurology, , Volume: 72, Issue:2, 2013
Limelight on alpha-synuclein: pathological and mechanistic implications in neurodegeneration.Journal of Parkinson's disease, , Volume: 3, Issue:4, 2013
Transmission of multiple system atrophy prions to transgenic mice.Proceedings of the National Academy of Sciences of the United States of America, , Nov-26, Volume: 110, Issue:48, 2013
Intact olfaction in a mouse model of multiple system atrophy.PloS one, , Volume: 8, Issue:5, 2013
Analysis of colonic alpha-synuclein pathology in multiple system atrophy.Parkinsonism & related disorders, , Volume: 18, Issue:7, 2012
Myeloperoxidase inhibition ameliorates multiple system atrophy-like degeneration in a transgenic mouse model.Neurotoxicity research, , Volume: 21, Issue:4, 2012
Neuronal to oligodendroglial α-synuclein redistribution in a double transgenic model of multiple system atrophy.Neuroreport, , Mar-07, Volume: 23, Issue:4, 2012
Cerebellar-type multiple system atrophy presenting with leucoencephalopathy.Journal of neurology, neurosurgery, and psychiatry, , Volume: 83, Issue:2, 2012
Animal models of multiple system atrophy.Neuroscience, , Jun-01, Volume: 211, 2012
Extensive distribution of glial cytoplasmic inclusions in an autopsied case of multiple system atrophy with a prolonged 18-year clinical course.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 32, Issue:1, 2012
Binding of neuronal α-synuclein to β-III tubulin and accumulation in a model of multiple system atrophy.Biochemical and biophysical research communications, , Jan-27, Volume: 417, Issue:4, 2012
Involvement of macroautophagy in multiple system atrophy and protein aggregate formation in oligodendrocytes.Journal of molecular neuroscience : MN, , Volume: 47, Issue:2, 2012
α-Synuclein accumulation reduces GABAergic inhibitory transmission in a model of multiple system atrophy.Biochemical and biophysical research communications, , Nov-23, Volume: 428, Issue:3, 2012
Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders.Archives of neurology, , Volume: 69, Issue:11, 2012
An antibody with high reactivity for disease-associated α-synuclein reveals extensive brain pathology.Acta neuropathologica, , Volume: 124, Issue:1, 2012
Increased neuronal α-synuclein pathology associates with its accumulation in oligodendrocytes in mice modeling α-synucleinopathies.PloS one, , Volume: 7, Issue:10, 2012
Post mortem cerebrospinal fluid α-synuclein levels are raised in multiple system atrophy and distinguish this from the other α-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies.Neurobiology of disease, , Volume: 45, Issue:1, 2012
The neuropathology, pathophysiology and genetics of multiple system atrophy.Neuropathology and applied neurobiology, , Volume: 38, Issue:1, 2012
Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease.BMC neuroscience, , Aug-03, Volume: 12, 2011
Cerebrospinal fluid from patients with multiple system atrophy promotes in vitro α-synuclein fibril formation.Neuroscience letters, , Mar-10, Volume: 491, Issue:1, 2011
Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression.Annals of neurology, , Volume: 69, Issue:3, 2011
Erythropoietin is neuroprotective in a transgenic mouse model of multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Feb-15, Volume: 26, Issue:3, 2011
Protein disulfide isomerase immunopositive glial cytoplasmic inclusions in patients with multiple system atrophy.The International journal of neuroscience, , Volume: 121, Issue:10, 2011
Multiple system atrophy: a clinical and neuropathological perspective.Trends in neurosciences, , Volume: 34, Issue:11, 2011
New insights into atypical parkinsonism.Current opinion in neurology, , Volume: 24, Issue:4, 2011
[Multiple system atrophy - synuclein and neuronal degeneration].Rinsho shinkeigaku = Clinical neurology, , Volume: 51, Issue:11, 2011
Tau-positive glial cytoplasmic granules in multiple system atrophy.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 31, Issue:3, 2011
α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study.The Lancet. Neurology, , Volume: 10, Issue:3, 2011
Mesenchymal stem cells in a transgenic mouse model of multiple system atrophy: immunomodulation and neuroprotection.PloS one, , Volume: 6, Issue:5, 2011
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein.The Journal of biological chemistry, , Sep-30, Volume: 286, Issue:39, 2011
Neuropathology underlying clinical variability in patients with synucleinopathies.Acta neuropathologica, , Volume: 122, Issue:2, 2011
Neurodegeneration in a transgenic mouse model of multiple system atrophy is associated with altered expression of oligodendroglial-derived neurotrophic factors.The Journal of neuroscience : the official journal of the Society for Neuroscience, , May-05, Volume: 30, Issue:18, 2010
Alpha-synuclein deficient mice are resistant to toxin-induced multiple system atrophy.Neuroreport, , Apr-21, Volume: 21, Issue:6, 2010
Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease.Acta neuropathologica, , Volume: 119, Issue:6, 2010
Reply to: SNCA variants are associated with increased risk of multiple system atrophy.Annals of neurology, , Volume: 67, Issue:3, 2010
Role of TPPP/p25 on α-synuclein-mediated oligodendroglial degeneration and the protective effect of SIRT2 inhibition in a cellular model of multiple system atrophy.Neurochemistry international, , Volume: 57, Issue:8, 2010
Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation.Brain : a journal of neurology, , Volume: 133, Issue:Pt 1, 2010
Targeted overexpression of human alpha-synuclein in oligodendroglia induces lesions linked to MSA-like progressive autonomic failure.Experimental neurology, , Volume: 224, Issue:2, 2010
In vivo visualization of alpha-synuclein deposition by carbon-11-labelled 2-[2-(2-dimethylaminothiazol-5-yl)ethenyl]-6-[2-(fluoro)ethoxy]benzoxazole positron emission tomography in multiple system atrophy.Brain : a journal of neurology, , Volume: 133, Issue:Pt 6, 2010
SNCA variants and multiple system atrophy.Annals of neurology, , Volume: 67, Issue:4, 2010
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-03, Volume: 30, Issue:9, 2010
Involvement of endoplasmic reticulum stress defined by activated unfolded protein response in multiple system atrophy.Journal of the neurological sciences, , Oct-15, Volume: 297, Issue:1-2, 2010
REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century.Neurology, , Aug-10, Volume: 75, Issue:6, 2010
Concomitant progressive supranuclear palsy and multiple system atrophy: more than a simple twist of fate?Neuroscience letters, , Dec-31, Volume: 467, Issue:3, 2009
Leucine-rich repeat kinase 2 expression leads to aggresome formation that is not associated with alpha-synuclein inclusions.Journal of neuropathology and experimental neurology, , Volume: 68, Issue:7, 2009
Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy.PloS one, , Sep-22, Volume: 4, Issue:9, 2009
Microtubule depolymerization suppresses alpha-synuclein accumulation in a mouse model of multiple system atrophy.The American journal of pathology, , Volume: 174, Issue:4, 2009
Dopamine cell loss in the periaqueductal gray in multiple system atrophy and Lewy body dementia.Neurology, , Jul-14, Volume: 73, Issue:2, 2009
Definite multiple system atrophy in a German family.Journal of neurology, neurosurgery, and psychiatry, , Volume: 80, Issue:4, 2009
Degeneration in different parkinsonian syndromes relates to astrocyte type and astrocyte protein expression.Journal of neuropathology and experimental neurology, , Volume: 68, Issue:10, 2009
Striatal transplantation for multiple system atrophy--are grafts affected by alpha-synucleinopathy?Experimental neurology, , Volume: 219, Issue:1, 2009
[Mechanism of neuronal degeneration of multiple system atrophy].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 61, Issue:9, 2009
Glucocerebrosidase mutations in 108 neuropathologically confirmed cases of multiple system atrophy.Neurology, , Mar-31, Volume: 72, Issue:13, 2009
Multiple system atrophy: an update.The Lancet. Neurology, , Volume: 8, Issue:12, 2009
Recent developments in multiple system atrophy.Journal of neurology, , Volume: 256, Issue:11, 2009
Mitochondrial inhibitor 3-nitroproprionic acid enhances oxidative modification of alpha-synuclein in a transgenic mouse model of multiple system atrophy.Journal of neuroscience research, , Volume: 87, Issue:12, 2009
SNCA variants are associated with increased risk for multiple system atrophy.Annals of neurology, , Volume: 65, Issue:5, 2009
Glial cytoplasmic inclusions in neurologically normal elderly: prodromal multiple system atrophy?Acta neuropathologica, , Volume: 116, Issue:3, 2008
Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:10, 2008
Loss of A5 noradrenergic neurons in multiple system atrophy.Acta neuropathologica, , Volume: 115, Issue:6, 2008
Differential expression of alpha-synuclein, parkin, and synphilin-1 isoforms in Lewy body disease.Neurogenetics, , Volume: 9, Issue:3, 2008
LRRK2 and parkin immunoreactivity in multiple system atrophy inclusions.Acta neuropathologica, , Volume: 116, Issue:6, 2008
alpha-Synuclein gene duplication is present in sporadic Parkinson disease.Neurology, , Jan-01, Volume: 70, Issue:1, 2008
Multiple system atrophy: a primary oligodendrogliopathy.Annals of neurology, , Volume: 64, Issue:3, 2008
The somatosensory cortex in multiple system atrophy.Journal of the neurological sciences, , Aug-15, Volume: 271, Issue:1-2, 2008
Parkinson's disease with Onuf's nucleus involvement mimicking multiple system atrophy.Journal of neurology, neurosurgery, and psychiatry, , Volume: 79, Issue:2, 2008
Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease.Brain : a journal of neurology, , Volume: 131, Issue:Pt 3, 2008
Analyses of copy number and mRNA expression level of the alpha-synuclein gene in multiple system atrophy.Journal of medical and dental sciences, , Volume: 55, Issue:1, 2008
Rasagiline is neuroprotective in a transgenic model of multiple system atrophy.Experimental neurology, , Volume: 210, Issue:2, 2008
Rifampicin reduces alpha-synuclein in a transgenic mouse model of multiple system atrophy.Neuroreport, , Aug-27, Volume: 19, Issue:13, 2008
Second consensus statement on the diagnosis of multiple system atrophy.Neurology, , Aug-26, Volume: 71, Issue:9, 2008
Multiple system atrophy in a patient with the spinocerebellar ataxia 3 gene mutation.Movement disorders : official journal of the Movement Disorder Society, , Jan-15, Volume: 22, Issue:2, 2007
PINK1, a gene product of PARK6, accumulates in alpha-synucleinopathy brains.Journal of neurology, neurosurgery, and psychiatry, , Volume: 78, Issue:6, 2007
Depletion of putative chemosensitive respiratory neurons in the ventral medullary surface in multiple system atrophy.Brain : a journal of neurology, , Volume: 130, Issue:Pt 2, 2007
Mutant ubiquitin and p62 immunoreactivity in cases of combined multiple system atrophy and Alzheimer's disease.Acta neuropathologica, , Volume: 113, Issue:4, 2007
Synucleinopathy with features of both multiple system atrophy and dementia with Lewy bodies.Neuropathology and applied neurobiology, , Volume: 33, Issue:1, 2007
Accumulation of Hsc70 and Hsp70 in glial cytoplasmic inclusions in patients with multiple system atrophy.Brain research, , Mar-09, Volume: 1136, Issue:1, 2007
Gene expression changes in postmortem tissue from the rostral pons of multiple system atrophy patients.Movement disorders : official journal of the Movement Disorder Society, , Apr-30, Volume: 22, Issue:6, 2007
Quantitative PCR-based screening of alpha-synuclein multiplication in multiple system atrophy.Parkinsonism & related disorders, , Volume: 13, Issue:6, 2007
Tauopathies and synucleinopathies: do cerebrospinal fluid beta-amyloid peptides reflect disease-specific pathogenesis?Journal of neural transmission (Vienna, Austria : 1996), , Volume: 114, Issue:7, 2007
Multiplex families with multiple system atrophy.Archives of neurology, , Volume: 64, Issue:4, 2007
High dose levodopa therapy is not toxic in multiple system atrophy: experimental evidence.Movement disorders : official journal of the Movement Disorder Society, , May-15, Volume: 22, Issue:7, 2007
Rostral raphe involvement in Lewy body dementia and multiple system atrophy.Acta neuropathologica, , Volume: 114, Issue:3, 2007
p25alpha relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy.The American journal of pathology, , Volume: 171, Issue:4, 2007
Microglial activation mediates neurodegeneration related to oligodendroglial alpha-synucleinopathy: implications for multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Nov-15, Volume: 22, Issue:15, 2007
Transgenic animal models of neurodegenerative diseases and their application to treatment development.Advanced drug delivery reviews, , Sep-30, Volume: 59, Issue:11, 2007
Phosphorylated Smad 2/3 colocalizes with phospho-tau inclusions in Pick disease, progressive supranuclear palsy, and corticobasal degeneration but not with alpha-synuclein inclusions in multiple system atrophy or dementia with Lewy bodies.Journal of neuropathology and experimental neurology, , Volume: 66, Issue:11, 2007
Multiple system atrophy: alpha-synuclein and neuronal degeneration.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 27, Issue:5, 2007
Pontine calcification in a case with cerebellar type of multiple system atrophy: incidental or related to synucleinopathy.Internal medicine (Tokyo, Japan), , Volume: 45, Issue:9, 2006
alpha-synuclein from platelets is not phosphorylated at serine 129 in Parkinson's disease and multiple system atrophy.Neuroscience letters, , Sep-25, Volume: 405, Issue:3, 2006
Cellular pathology in multiple system atrophy.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 26, Issue:4, 2006
P25alpha immunoreactive but alpha-synuclein immunonegative neuronal inclusions in multiple system atrophy.Acta neuropathologica, , Volume: 111, Issue:2, 2006
Coexistence of PSP and MSA: a case report and review of the literature.Acta neuropathologica, , Volume: 111, Issue:2, 2006
The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 113, Issue:10, 2006
The alpha-synuclein gene in multiple system atrophy.Journal of neurology, neurosurgery, and psychiatry, , Volume: 77, Issue:4, 2006
REM sleep behavior disorder: a possible early marker for synucleinopathies.Neurology, , Mar-28, Volume: 66, Issue:6, 2006
[Subthalamic stimulation in a patient with multiple system atrophy: a clinicopathological report].Revue neurologique, , Volume: 162, Issue:3, 2006
P25alpha immunoreactivity in multiple system atrophy and Parkinson disease.Acta neuropathologica, , Volume: 112, Issue:1, 2006
Multiple system atrophy (MSA): topographic distribution of the alpha-synuclein-associated pathological changes.Parkinsonism & related disorders, , Volume: 12, Issue:6, 2006
The role of alpha-synuclein in the pathogenesis of multiple system atrophy.Acta neuropathologica, , Volume: 109, Issue:2, 2005
Atypical parkinsonism combining alpha-synuclein inclusions and polyglucosan body disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20, Issue:2, 2005
Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy.The American journal of pathology, , Volume: 166, Issue:3, 2005
Mouse model of multiple system atrophy alpha-synuclein expression in oligodendrocytes causes glial and neuronal degeneration.Neuron, , Mar-24, Volume: 45, Issue:6, 2005
Glial cell cytoplasmic inclusions in SCA2 do not express alpha-synuclein.Journal of neurology, , Volume: 252, Issue:6, 2005
alpha-Synuclein-immunoreactive structure formation is enhanced in sympathetic ganglia of patients with multiple system atrophy.Acta neuropathologica, , Volume: 110, Issue:1, 2005
Alpha-synuclein overexpression in oligodendrocytic cells results in impaired adhesion to fibronectin and cell death.Molecular and cellular neurosciences, , Volume: 29, Issue:2, 2005
Silver stainings distinguish Lewy bodies and glial cytoplasmic inclusions: comparison between Gallyas-Braak and Campbell-Switzer methods.Acta neuropathologica, , Volume: 110, Issue:3, 2005
Grading of neuropathology in multiple system atrophy: proposal for a novel scale.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
In vitro models of multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
In vivo models of multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
Alpha-synuclein transgenic mice: relevance to multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
Progressive accumulation of ubiquitin and disappearance of alpha-synuclein epitope in multiple system atrophy-associated glial cytoplasmic inclusions: triple fluorescence study combined with Gallyas-Braak method.Acta neuropathologica, , Volume: 110, Issue:4, 2005
Absence of alpha-synuclein mRNA expression in normal and multiple system atrophy oligodendroglia.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 112, Issue:12, 2005
Neurological and neurodegenerative alterations in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-16, Volume: 25, Issue:46, 2005
Alpha-synuclein immunoreactivity in neuronal nuclear inclusions and neurites in multiple system atrophy.Neuroscience letters, , Jan-09, Volume: 354, Issue:2, 2004
Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy.Acta neuropathologica, , Volume: 107, Issue:4, 2004
Spatial patterns of alpha-synuclein positive glial cytoplasmic inclusions in multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 19, Issue:1, 2004
Microglial activation parallels system degeneration in multiple system atrophy.Journal of neuropathology and experimental neurology, , Volume: 63, Issue:1, 2004
Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease.Acta neuropathologica, , Volume: 107, Issue:6, 2004
Pael-R is accumulated in Lewy bodies of Parkinson's disease.Annals of neurology, , Volume: 55, Issue:3, 2004
Alpha-synuclein: normal function and role in neurodegenerative diseases.Current topics in developmental biology, , Volume: 60, 2004
Annular alpha-synuclein species from purified multiple system atrophy inclusions.Journal of neurochemistry, , Volume: 90, Issue:2, 2004
A quantitative investigation of neuronal cytoplasmic and intranuclear inclusions in the pontine and inferior olivary nuclei in multiple system atrophy.Neuropathology and applied neurobiology, , Volume: 30, Issue:5, 2004
Tau and 14-3-3 in glial cytoplasmic inclusions of multiple system atrophy.Acta neuropathologica, , Volume: 106, Issue:3, 2003
[Recent neuropathology of parkinsonian syndromes].Revue neurologique, , Volume: 159, Issue:5 Pt 2, 2003
alpha-Synuclein fibrils constitute the central core of oligodendroglial inclusion filaments in multiple system atrophy.Experimental neurology, , Volume: 181, Issue:1, 2003
Immunoexpression of 14-3-3 proteins in glial cytoplasmic inclusions of multiple system atrophy.Acta neuropathologica, , Volume: 106, Issue:1, 2003
Alpha-synuclein pathology affecting Bergmann glia of the cerebellum in patients with alpha-synucleinopathies.Acta neuropathologica, , Volume: 105, Issue:4, 2003
Nucleus-specific alteration of raphe neurons in human neurodegenerative disorders.Neuroreport, , Jan-20, Volume: 14, Issue:1, 2003
Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies.The American journal of pathology, , Volume: 163, Issue:1, 2003
Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis.The American journal of pathology, , Volume: 163, Issue:2, 2003
Multiple system atrophy: an update.Movement disorders : official journal of the Movement Disorder Society, , Volume: 18 Suppl 6, 2003
Alpha-synuclein accumulates in Purkinje cells in Lewy body disease but not in multiple system atrophy.Journal of neuropathology and experimental neurology, , Volume: 62, Issue:8, 2003
Reciprocal accumulation of beta-synuclein in alpha-synuclein lesions in multiple system atrophy.Neuroreport, , Oct-06, Volume: 14, Issue:14, 2003
Alpha-synuclein immunoreactivity and ultrastructural study of glial cytoplasmic inclusions in multiple system atrophy.Chinese medical journal, , Volume: 115, Issue:10, 2002
Association of Lewy bodies and glial cytoplasmic inclusions in the brain of Parkinson's disease.Acta neuropathologica, , Volume: 104, Issue:5, 2002
Mice expressing the alpha(1B)-adrenergic receptor induces a synucleinopathy with excessive tyrosine nitration but decreased phosphorylation.Journal of neurochemistry, , Volume: 83, Issue:3, 2002
Mixed multiple system atrophy and progressive supranuclear palsy: a clinical and pathological report of one case.Acta neuropathologica, , Volume: 103, Issue:1, 2002
Clusterin/apolipoprotein J is associated with cortical Lewy bodies: immunohistochemical study in cases with alpha-synucleinopathies.Acta neuropathologica, , Volume: 104, Issue:3, 2002
Oligodendrocytes from neural stem cells express alpha-synuclein: increased numbers from presenilin 1 deficient mice.Neuroreport, , Jul-19, Volume: 13, Issue:10, 2002
[Recent progress in the research of multiple system atrophy with special references to alpha-synuclein and suprachiasmatic nucleus].No to shinkei = Brain and nerve, , Volume: 54, Issue:2, 2002
Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters.Journal of neuroscience research, , Jun-01, Volume: 68, Issue:5, 2002
Pathology of the inferior olivary nucleus in patients with multiple system atrophy.Acta neuropathologica, , Volume: 103, Issue:6, 2002
Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes.EMBO reports, , Volume: 3, Issue:6, 2002
Depletion of cholinergic neurons of the medullary arcuate nucleus in multiple system atrophy.Autonomic neuroscience : basic & clinical, , Mar-23, Volume: 87, Issue:2-3, 2001
Analysis of the expression level of alpha-synuclein mRNA using postmortem brain samples from pathologically confirmed cases of multiple system atrophy.Acta neuropathologica, , Volume: 102, Issue:2, 2001
Multiple system atrophy: cellular and molecular pathology.Molecular pathology : MP, , Volume: 54, Issue:6, 2001
The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease.Journal of neurochemistry, , Volume: 76, Issue:1, 2001
Synucleinopathies: clinical and pathological implications.Archives of neurology, , Volume: 58, Issue:2, 2001
alpha-Synuclein forms a complex with transcription factor Elk-1.Journal of neurochemistry, , Volume: 77, Issue:1, 2001
Co-localization of alpha-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration.Acta neuropathologica, , Volume: 101, Issue:3, 2001
[Alpha-synucleinopathies].Neurologia (Barcelona, Spain), , Volume: 16, Issue:4, 2001
Alpha-synuclein and neurodegenerative diseases.Nature reviews. Neuroscience, , Volume: 2, Issue:7, 2001
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions.Science (New York, N.Y.), , Nov-03, Volume: 290, Issue:5493, 2000
The pathogenesis of multiple system atrophy: past, present, and future.Movement disorders : official journal of the Movement Disorder Society, , Volume: 15, Issue:5, 2000
Immunohistochemical and biochemical studies demonstrate a distinct profile of alpha-synuclein permutations in multiple system atrophy.Journal of neuropathology and experimental neurology, , Volume: 59, Issue:9, 2000
Characterisation of isolated alpha-synuclein filaments from substantia nigra of Parkinson's disease brain.Neuroscience letters, , Oct-06, Volume: 292, Issue:2, 2000
Late-onset neurodegenerative diseases--the role of protein insolubility.Journal of anatomy, , Volume: 196 ( Pt 4), 2000
Multiple system atrophy/progressive supranuclear palsy: alpha-Synuclein, synphilin, tau, and APOE.Neurology, , Dec-26, Volume: 55, Issue:12, 2000
The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.Annals of the New York Academy of Sciences, , Volume: 920, 2000
Depression in alpha-synucleinopathies: prevalence, pathophysiology and treatment.Journal of neural transmission. Supplementum, , Issue:60, 2000
Alpha-synuclein and Parkinson's disease.Cellular and molecular life sciences : CMLS, , Volume: 57, Issue:13-14, 2000
The expression of alpha-, beta-, and gamma-synucleins in olfactory mucosa from patients with and without neurodegenerative diseases.Experimental neurology, , Volume: 160, Issue:2, 1999
The genetics of disorders with synuclein pathology and parkinsonism.Human molecular genetics, , Volume: 8, Issue:10, 1999
Widespread alterations of alpha-synuclein in multiple system atrophy.The American journal of pathology, , Volume: 155, Issue:4, 1999
Alpha-synuclein immunoisolation of glial inclusions from multiple system atrophy brain tissue reveals multiprotein components.Journal of neurochemistry, , Volume: 73, Issue:5, 1999
No mutation in the entire coding region of the alpha-synuclein gene in pathologically confirmed cases of multiple system atrophy.Neuroscience letters, , Jul-30, Volume: 270, Issue:2, 1999
Multiple system atrophy: a sporadic synucleinopathy.Brain pathology (Zurich, Switzerland), , Volume: 9, Issue:4, 1999
Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies.Neuroscience letters, , Jul-31, Volume: 251, Issue:3, 1998
Accumulation of alpha-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy.Acta neuropathologica, , Volume: 96, Issue:5, 1998
Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein.Annals of neurology, , Volume: 44, Issue:3, 1998
Alpha synuclein in neurodegenerative disorders: murderer or accomplice?Nature medicine, , Volume: 4, Issue:7, 1998
Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy.Neuroscience letters, , Jun-19, Volume: 249, Issue:2-3, 1998
Multiple-system atrophy: a new alpha-synuclein disease?Lancet (London, England), , Aug-15, Volume: 352, Issue:9127, 1998
Transplantation of Adipose-Derived Stem Cells Alleviates Striatal Degeneration in a Transgenic Mouse Model for Multiple System Atrophy.Cell transplantation, , Volume: 29
Cognitive and neuropsychiatric profile of the synucleinopathies: Parkinson disease, dementia with Lewy bodies, and multiple system atrophy.Alzheimer disease and associated disorders, , Volume: 23, Issue:4
Alpha-synuclein in the cerebrospinal fluid differentiates synucleinopathies (Parkinson Disease, dementia with Lewy bodies, multiple system atrophy) from Alzheimer disease.Alzheimer disease and associated disorders, , Volume: 26, Issue:3
Detection of Dermal Alpha-Synuclein Deposits as a Biomarker for Parkinson's Disease.Journal of Parkinson's disease, , Volume: 11, Issue:3
Multiple system atrophy of the cerebellar type (MSA-C) with concomitant beta-amyloid and tau pathology.Clinical neuropathology, , Volume: 32, Issue:4
Abundant glial alpha-synuclein pathology in a case without overt clinical symptoms.Clinical neuropathology, , Volume: 26, Issue:6
Genetic deletion of Polo-like kinase 2 reduces alpha-synuclein serine-129 phosphorylation in presynaptic terminals but not Lewy bodies.The Journal of biological chemistry, , Volume: 296
Feasibility and considerations of epsin2 as a candidate target for multiple system atrophy treatment.Expert opinion on therapeutic targets, , Volume: 27, Issue:11
Alpha-synuclein binding to rab3a in multiple system atrophy.Neuroscience letters, , Volume: 380, Issue:1-2
SUMO-1 marks subdomains within glial cytoplasmic inclusions of multiple system atrophy.Neuroscience letters, , Volume: 381, Issue:1-2
Alpha-synuclein Levels in the Differential Diagnosis of Lewy Bodies Dementia and Other Neurodegenerative Disorders: A Meta-analysis.Alzheimer disease and associated disorders, , Volume: 34, Issue:3
Ashwagandha- Withania somnifera (L.) Dunal as a multipotent neuroprotective remedy for genetically induced motor dysfunction and cellular toxicity in human neurodegenerative disease models of Drosophila.Journal of ethnopharmacology, , Jan-10, Volume: 318, Issue:Pt A, 2024
Anti-α-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson's disease.Neurobiology of disease, , Volume: 177, 2023
Mitochondrial signaling on innate immunity activation in Parkinson disease.Current opinion in neurobiology, , Volume: 78, 2023
The interaction between alpha-synuclein and mitochondrial dysfunction in Parkinson's disease.Biophysical chemistry, , Volume: 303, 2023
Axonal Transport of Lysosomes Is Unaffected in Glucocerebrosidase-Inhibited iPSC-Derived Forebrain Neurons.eNeuro, , Volume: 10, Issue:10, 2023
Identifying the potential genes in alpha synuclein driving ferroptosis of Parkinson's disease.Scientific reports, , 10-06, Volume: 13, Issue:1, 2023
Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids.Nature, , Volume: 621, Issue:7980, 2023
Low-dose Cu exposure enhanced α-synuclein accumulation associates with mitochondrial impairments in mice model of Parkinson's disease.Toxicology letters, , Sep-15, Volume: 387, 2023
Proteostasis in Parkinson's disease: Recent development and possible implication in diagnosis and therapeutics.Ageing research reviews, , Volume: 84, 2023
Association between SGK1 and α-synuclein in skeletal muscle in an MPTP-induced Parkinson's disease model.Neuroscience letters, , 09-25, Volume: 814, 2023
Tuning Hsp104 specificity to selectively detoxify α-synuclein.Molecular cell, , 09-21, Volume: 83, Issue:18, 2023
Associations of phosphorylated tau pathology with whole-hemisphere ex vivo morphometry in 7 tesla MRI.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 19, Issue:6, 2023
Heterotypic liquid-liquid phase separation of tau and α-synuclein: Implications for overlapping neuropathologies.Biochimica et biophysica acta. Proteins and proteomics, , 11-01, Volume: 1871, Issue:6, 2023
Effect of flavonoids on the destabilization of α-synuclein fibrils and their conversion to amorphous aggregate: A molecular dynamics simulation and experimental study.Biochimica et biophysica acta. Proteins and proteomics, , 11-01, Volume: 1871, Issue:6, 2023
Investigation of Inflammation in Lewy Body Dementia: A Systematic Scoping Review.International journal of molecular sciences, , Jul-28, Volume: 24, Issue:15, 2023
Omics Analyses in a Neural Stem Cell Model of Familial Parkinson's Disease.Advances in experimental medicine and biology, , Volume: 1423, 2023
An Update on Peripheral Blood Extracellular Vesicles as Biomarkers for Parkinson's Disease Diagnosis.Neuroscience, , 02-10, Volume: 511, 2023
Brain-Biomarker Changes in Body Fluids of Patients with Parkinson's Disease.International journal of molecular sciences, , Jun-30, Volume: 24, Issue:13, 2023
ARL6IP5 Ameliorates α-Synuclein Burden by Inducing Autophagy via Preventing Ubiquitination and Degradation of ATG12.International journal of molecular sciences, , Jun-22, Volume: 24, Issue:13, 2023
Development of an α-synuclein positron emission tomography tracer for imaging synucleinopathies.Cell, , 08-03, Volume: 186, Issue:16, 2023
Development of a hydroxyflavone-labelled 4554W peptide probe for monitoring αS aggregation.Scientific reports, , 07-06, Volume: 13, Issue:1, 2023
Potential application of heat shock proteins as therapeutic targets in Parkinson's disease.Neurochemistry international, , Volume: 162, 2023
Seed Amplification Assay as a Diagnostic Tool in Newly-Diagnosed Parkinson's Disease.Journal of Parkinson's disease, , Volume: 13, Issue:5, 2023
Endocytic pathways of pathogenic protein aggregates in neurodegenerative diseases.Traffic (Copenhagen, Denmark), , Volume: 24, Issue:10, 2023
Targeting α-synuclein post-translational modifications in Parkinson's disease.Behavioural brain research, , 02-15, Volume: 439, 2023
Unveiling How Hydroxytyrosol Destabilizes α-Syn Oligomers Using Molecular Simulations.The journal of physical chemistry. B, , 06-29, Volume: 127, Issue:25, 2023
Interlinked role of ASN, TDP-43 and Miro1 with parkinopathy: Focus on targeted approach against neuropathy in parkinsonism.Ageing research reviews, , Volume: 83, 2023
The loss of function GBA1 c.231C > G mutation associated with Parkinson disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 130, Issue:7, 2023
Microglia and astrocyte activation is region-dependent in the α-synuclein mouse model of Parkinson's disease.Glia, , Volume: 71, Issue:3, 2023
Targeting Sigma-1 Receptor: A Promising Strategy in the Treatment of Parkinson's Disease.Neurochemical research, , Volume: 48, Issue:10, 2023
Intestinal infection triggers mitochondria-mediated α-synuclein pathology: relevance to Parkinson's disease.Cellular and molecular life sciences : CMLS, , May-30, Volume: 80, Issue:6, 2023
Single-Particle Analysis of the Interaction Between Molecules and Protein Aggregated Species by Dual-Color Time-Resolved Fluorescence Spectroscopy.Methods in molecular biology (Clifton, N.J.), , Volume: 2551, 2023
NF-κB/NLRP3 inflammasome axis and risk of Parkinson's disease in Type 2 diabetes mellitus: A narrative review and new perspective.Journal of cellular and molecular medicine, , Volume: 27, Issue:13, 2023
Microglia-specific knock-out of NF-κB/IKK2 increases the accumulation of misfolded α-synuclein through the inhibition of p62/sequestosome-1-dependent autophagy in the rotenone model of Parkinson's disease.Glia, , Volume: 71, Issue:9, 2023
Research Progress of α-Synuclein Aggregation Inhibitors for Potential Parkinson's Disease Treatment.Mini reviews in medicinal chemistry, , Volume: 23, Issue:20, 2023
Impact of sex on neuroimmune contributions to Parkinson's disease.Brain research bulletin, , Volume: 199, 2023
Tau seeds occur before earliest Alzheimer's changes and are prevalent across neurodegenerative diseases.Acta neuropathologica, , Volume: 146, Issue:1, 2023
The Endo-lysosomal System in Parkinson's Disease: Expanding the Horizon.Journal of molecular biology, , 06-15, Volume: 435, Issue:12, 2023
Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.Molecular neurodegeneration, , 05-02, Volume: 18, Issue:1, 2023
[no title available]Oxidative medicine and cellular longevity, , Volume: 2023, 2023
Pathophysiology and Neuroimmune Interactions Underlying Parkinson's Disease and Traumatic Brain Injury.International journal of molecular sciences, , Apr-13, Volume: 24, Issue:8, 2023
MALAT1 Mediates Mediators of inflammation, , Volume: 2023, 2023
Alpha Synuclein: Neurodegeneration and Inflammation.International journal of molecular sciences, , Mar-21, Volume: 24, Issue:6, 2023
Benefits of Gut Microbiota Reconstitution by Beta 1,3-1,6 Glucans in Subjects with Autism Spectrum Disorder and Other Neurodegenerative Diseases.Journal of Alzheimer's disease : JAD, , Volume: 94, Issue:s1, 2023
Gene Expression Profiling as a Novel Diagnostic Tool for Neurodegenerative Disorders.International journal of molecular sciences, , Mar-17, Volume: 24, Issue:6, 2023
Chemical Synthesis of Alpha-Synuclein Proteins via Solid-Phase Peptide Synthesis and Native Chemical Ligation.Chemistry (Weinheim an der Bergstrasse, Germany), , Jun-13, Volume: 29, Issue:33, 2023
Biochemical study of the effect of mesenchymal stem cells-derived exosome versus L-Dopa in experimentally induced Parkinson's disease in rats.Molecular and cellular biochemistry, , Volume: 478, Issue:12, 2023
Vinpocetine prevents rotenone-induced Parkinson disease motor and non-motor symptoms through attenuation of oxidative stress, neuroinflammation and α-synuclein expressions in rats.Neurotoxicology, , Volume: 96, 2023
Cannabidiol Recovers Dopaminergic Neuronal Damage Induced by Reserpine or α-synuclein in Caenorhabditis elegans.Neurochemical research, , Volume: 48, Issue:8, 2023
Activation of ROS-PERK-TFEB by filbertone ameliorates neurodegenerative diseases via enhancing the autophagy-lysosomal pathway.The Journal of nutritional biochemistry, , Volume: 118, 2023
Immunotherapeutic Approaches for the Treatment of Neurodegenerative Diseases: Challenges and Outcomes.CNS & neurological disorders drug targets, , Volume: 22, Issue:3, 2023
Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions.Proceedings of the National Academy of Sciences of the United States of America, , 03-28, Volume: 120, Issue:13, 2023
Recent Advances in the Treatment of Genetic Forms of Parkinson's Disease: Hype or Hope?Cells, , 02-27, Volume: 12, Issue:5, 2023
Unravelling the destabilization potential of ellagic acid on α-synuclein fibrils using molecular dynamics simulations.Physical chemistry chemical physics : PCCP, , Mar-15, Volume: 25, Issue:11, 2023
DJ-1 Molecular Chaperone Activity Depresses Tau Aggregation Propensity through Interaction with Monomers.Biochemistry, , 03-07, Volume: 62, Issue:5, 2023
Models of precision medicine for neurodegeneration.Handbook of clinical neurology, , Volume: 192, 2023
The alteration of intestinal mucosal α-synuclein expression and mucosal microbiota in Parkinson's disease.Applied microbiology and biotechnology, , Volume: 107, Issue:5-6, 2023
TNFRSF10B is involved in motor dysfunction in Parkinson's disease by regulating exosomal α-synuclein secretion from microglia.Journal of chemical neuroanatomy, , Volume: 129, 2023
Combined chronic copper exposure and aging lead to neurotoxicity in vivo.Neurotoxicology, , Volume: 95, 2023
The Ubiquitin Proteasome System as a Therapeutic Area in Parkinson's Disease.Neuromolecular medicine, , Volume: 25, Issue:3, 2023
Polymorphic Alpha-Synuclein Oligomers: Characterization and Differential Detection with Novel Corresponding Antibodies.Molecular neurobiology, , Volume: 60, Issue:5, 2023
Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein.Nature neuroscience, , Volume: 26, Issue:2, 2023
A review of the current research on in vivo and in vitro detection for alpha-synuclein: a biomarker of Parkinson's disease.Analytical and bioanalytical chemistry, , Volume: 415, Issue:9, 2023
The c-Abl inhibitor IkT-148009 suppresses neurodegeneration in mouse models of heritable and sporadic Parkinson's disease.Science translational medicine, , 01-18, Volume: 15, Issue:679, 2023
aSynPEP-DB: a database of biogenic peptides for inhibiting α-synuclein aggregation.Database : the journal of biological databases and curation, , 11-27, Volume: 2023, 2023
Potential Therapeutic Effects of Policosanol from Insect Wax on Caenorhabditis elegans Models of Parkinson's Disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 18, Issue:1-2, 2023
In Silico and In Vitro Study towards the Rational Design of 4,4'-Disarylbisthiazoles as a Selective α-Synucleinopathy Biomarker.International journal of molecular sciences, , Nov-17, Volume: 24, Issue:22, 2023
Folium Hibisci Mutabilis extract, a potent autophagy enhancer, exhibits neuroprotective properties in multiple models of neurodegenerative diseases.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 109, 2023
Role of α-synuclein in microglia: autophagy and phagocytosis balance neuroinflammation in Parkinson's disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.], , Volume: 72, Issue:3, 2023
Characterization of Molecular Tweezer Binding on α-Synuclein with Native Top-Down Mass Spectrometry and Ion Mobility-Mass Spectrometry Reveals a Mechanism for Aggregation Inhibition.Journal of the American Society for Mass Spectrometry, , Dec-06, Volume: 34, Issue:12, 2023
Antagonizing pathological α-synuclein-mediated neurodegeneration by J24335 via the activation of immunoproteasome.Toxicology and applied pharmacology, , Dec-01, Volume: 480, 2023
Alpha-Synuclein-Specific Regulatory T Cells Ameliorate Parkinson's Disease Progression in Mice.International journal of molecular sciences, , Oct-16, Volume: 24, Issue:20, 2023
The Effects of Lipids on α-Synuclein Aggregation In Vitro.Biomolecules, , 10-02, Volume: 13, Issue:10, 2023
Tau accumulation in degradative organelles is associated to lysosomal stress.Scientific reports, , 10-21, Volume: 13, Issue:1, 2023
Novel Molecular Targets and Mechanisms for Neuroprotective Modulation in Neurodegenerative Disorders.Central nervous system agents in medicinal chemistry, , Volume: 22, Issue:2, 2022
Automated quantification of neuronal swellings in a preclinical rodent model of Parkinson's disease detects region-specific changes in pathology.Journal of neuroscience methods, , 08-01, Volume: 378, 2022
The immunology of Parkinson's disease.Seminars in immunopathology, , Volume: 44, Issue:5, 2022
Can Berberine Serve as a New Therapy for Parkinson's Disease?Neurotoxicity research, , Volume: 40, Issue:4, 2022
Structures of tau and α-synuclein filaments from brains of patients with neurodegenerative diseases.Neurochemistry international, , Volume: 158, 2022
Skin alpha-synuclein deposit patterns: A predictor of Parkinson's disease subtypes.EBioMedicine, , Volume: 80, 2022
Novel insights into the role of circular RNAs in Parkinson disease: An emerging renaissance in the management of neurodegenerative diseases.Journal of neuroscience research, , Volume: 100, Issue:9, 2022
Beyond neurodegenerative diseases: α-synuclein in erythropoiesis.Hematology (Amsterdam, Netherlands), , Volume: 27, Issue:1, 2022
Treating Parkinson's Disease via Activation of BDNF/TrkB Signaling Pathways and Inhibition of Delta-Secretase.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 19, Issue:4, 2022
Brain atrophy in prodromal synucleinopathy is shaped by structural connectivity and gene expression.Brain : a journal of neurology, , 09-14, Volume: 145, Issue:9, 2022
Inflammation promotes synucleinopathy propagation.Experimental & molecular medicine, , Volume: 54, Issue:12, 2022
Loss of GBA in zebrafish leads to dopaminergic neurodegeneration, but overexpression of α-synuclein does not further worsen degeneration.Neuroreport, , 05-04, Volume: 33, Issue:7, 2022
Cholecystokinin and glucagon-like peptide-1 analogues regulate intestinal tight junction, inflammation, dopaminergic neurons and α-synuclein accumulation in the colon of two Parkinson's disease mouse models.European journal of pharmacology, , Jul-05, Volume: 926, 2022
New Insights and Implications of Natural Killer Cells in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
Overlap between Central and Peripheral Transcriptomes in Parkinson's Disease but Not Alzheimer's Disease.International journal of molecular sciences, , May-06, Volume: 23, Issue:9, 2022
Targeting alpha-synuclein or tau for treating neurodegenerative movement disorders.Revue neurologique, , Volume: 178, Issue:5, 2022
Hytrin loaded polydopamine-serotonin nanohybrid induces IDH2 mediated neuroprotective effect to alleviate Parkinson's disease.Biomaterials advances, , Volume: 133, 2022
α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 101, 2022
Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43.Acta neuropathologica, , Volume: 143, Issue:6, 2022
Exploring the Role of Ubiquitin-Proteasome System in Parkinson's Disease.Molecular neurobiology, , Volume: 59, Issue:7, 2022
Monoclonal Antibodies in Neurodegenerative Disease May Work, But They Don't Help: A Perspective from Physicians.Journal of Parkinson's disease, , Volume: 12, Issue:8, 2022
Design, Synthesis, and Biological Evaluation of Potent 20S Proteasome Activators for the Potential Treatment of α-Synucleinopathies.Journal of medicinal chemistry, , 05-12, Volume: 65, Issue:9, 2022
Reduction of the α-synuclein expression promotes slowing down early neuropathology development in the Journal of neurogenetics, , Volume: 36, Issue:1, 2022
7,8-Dihydroxyflavone ameliorates mitochondrial impairment and motor dysfunction in the α-synuclein 1-103 transgenic mice.Neurobiology of disease, , Volume: 169, 2022
Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases.Progress in neurobiology, , Volume: 214, 2022
Immune Response Modifications in the Genetic Forms of Parkinson's Disease: What Do We Know?International journal of molecular sciences, , Mar-23, Volume: 23, Issue:7, 2022
LncRNA HOTAIR promotes α-synuclein aggregation and apoptosis of SH-SY5Y cells by regulating miR-221-3p in Parkinson's disease.Experimental cell research, , 08-01, Volume: 417, Issue:1, 2022
α-Synuclein arginylation in the human brain.Translational neurodegeneration, , 04-08, Volume: 11, Issue:1, 2022
Ubiquitin-positive astrogliopathy clinically mimicking Parkinson's disease.Acta neuropathologica communications, , 11-14, Volume: 10, Issue:1, 2022
Distribution of α-Synuclein Aggregation in the Peripheral Tissues.Neurochemical research, , Volume: 47, Issue:12, 2022
The Role of NEDD4 E3 Ubiquitin-Protein Ligases in Parkinson's Disease.Genes, , 03-14, Volume: 13, Issue:3, 2022
Immune responses in the Parkinson's disease brain.Neurobiology of disease, , 06-15, Volume: 168, 2022
Propagation of tau and α-synuclein in the brain: therapeutic potential of the glymphatic system.Translational neurodegeneration, , 03-21, Volume: 11, Issue:1, 2022
Celastrol Downmodulates Alpha-Synuclein-Specific T Cell Responses by Mediating Antigen Trafficking in Dendritic Cells.Frontiers in immunology, , Volume: 13, 2022
Glymphatic System Dysfunction and Sleep Disturbance May Contribute to the Pathogenesis and Progression of Parkinson's Disease.International journal of molecular sciences, , Oct-26, Volume: 23, Issue:21, 2022
Synthesis and evaluation of novel radioiodinated phenylbenzofuranone derivatives as α-synuclein imaging probes.Bioorganic & medicinal chemistry letters, , 05-15, Volume: 64, 2022
[Role of fatty acid-binding protein 7 and novel therapeutic approach in synucleinopathies].Nihon yakurigaku zasshi. Folia pharmacologica Japonica, , Volume: 157, Issue:6, 2022
Regulation by Different Types of Chaperones of Amyloid Transformation of Proteins Involved in the Development of Neurodegenerative Diseases.International journal of molecular sciences, , Mar-02, Volume: 23, Issue:5, 2022
Association Between Pathophysiological Mechanisms of Diabetic Retinopathy and Parkinson's Disease.Cellular and molecular neurobiology, , Volume: 42, Issue:3, 2022
Pathophysiological significance of increased α-synuclein deposition in sympathetic nerves in Parkinson's disease: a post-mortem observational study.Translational neurodegeneration, , 03-08, Volume: 11, Issue:1, 2022
Gene therapy of yeast NDI1 on mitochondrial complex I dysfunction in rotenone-induced Parkinson's disease models in vitro and vivo.Molecular medicine (Cambridge, Mass.), , 03-07, Volume: 28, Issue:1, 2022
Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies.Cellular and molecular life sciences : CMLS, , Mar-04, Volume: 79, Issue:3, 2022
[A role of human microbiota in the development of neurodegenerative diseases].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, , Volume: 122, Issue:10, 2022
Molecular Insights into the Misfolding and Dimerization Dynamics of the Full-Length α-Synuclein from Atomistic Discrete Molecular Dynamics Simulations.ACS chemical neuroscience, , 11-02, Volume: 13, Issue:21, 2022
The role of lysosomal cathepsins in neurodegeneration: Mechanistic insights, diagnostic potential and therapeutic approaches.Biochimica et biophysica acta. Molecular cell research, , Volume: 1869, Issue:7, 2022
The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity.Molecules (Basel, Switzerland), , Feb-15, Volume: 27, Issue:4, 2022
Liquid-Liquid Phase Separation Promotes Protein Aggregation and Its Implications in Ferroptosis in Parkinson's Disease Dementia.Oxidative medicine and cellular longevity, , Volume: 2022, 2022
The Potential Role of Voltage-Dependent Anion Channel in the Treatment of Parkinson's Disease.Oxidative medicine and cellular longevity, , Volume: 2022, 2022
The Antioxidative Effects of Picein and Its Neuroprotective Potential: A Review of the Literature.Molecules (Basel, Switzerland), , Sep-21, Volume: 27, Issue:19, 2022
Neuroprotective Function of Rasagiline and Selegiline, Inhibitors of Type B Monoamine Oxidase, and Role of Monoamine Oxidases in Synucleinopathies.International journal of molecular sciences, , Sep-21, Volume: 23, Issue:19, 2022
Global, in situ analysis of the structural proteome in individuals with Parkinson's disease to identify a new class of biomarker.Nature structural & molecular biology, , Volume: 29, Issue:10, 2022
Characterization of molecular biomarkers in cerebrospinal fluid and serum of E46K-SNCA mutation carriers.Parkinsonism & related disorders, , Volume: 96, 2022
Smell deficits in COVID-19 and possible links with Parkinson's disease.International review of neurobiology, , Volume: 165, 2022
Progress in Parkinson's disease animal models of genetic defects: Characteristics and application.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 155, 2022
Regulation of Parkinson's disease-associated genes by Pumilio proteins and microRNAs in SH-SY5Y neuronal cells.PloS one, , Volume: 17, Issue:9, 2022
Living in α-syn: Tackling aggregates in Parkinson's disease.Neuron, , 02-02, Volume: 110, Issue:3, 2022
α-Syn overexpression, NRF2 suppression, and enhanced ferroptosis create a vicious cycle of neuronal loss in Parkinson's disease.Free radical biology & medicine, , 11-01, Volume: 192, 2022
Biomarkers Related to Synaptic Dysfunction to Discriminate Alzheimer's Disease from Other Neurological Disorders.International journal of molecular sciences, , Sep-16, Volume: 23, Issue:18, 2022
Central and Enteric Neuroprotective Effects by Eucommia ulmoides Extracts on Neurodegeneration in Rotenone-induced Parkinsonian Mouse.Acta medica Okayama, , Volume: 76, Issue:4, 2022
Distinct neurotoxic TDP-43 fibril polymorphs are generated by heterotypic interactions with α-Synuclein.The Journal of biological chemistry, , Volume: 298, Issue:11, 2022
Phosphorylation of endogenous α-synuclein induced by extracellular seeds initiates at the pre-synaptic region and spreads to the cell body.Scientific reports, , 01-21, Volume: 12, Issue:1, 2022
[Aggregation and spread of synuclein in Parkinson's disease].Medecine sciences : M/S, , Volume: 38, Issue:1, 2022
Analysis of the Biomarkers for Neurodegenerative Diseases in Aged Progranulin Deficient Mice.International journal of molecular sciences, , Jan-06, Volume: 23, Issue:2, 2022
Propagation of Parkinson's disease by extracellular vesicle production and secretion.Biochemical Society transactions, , 10-31, Volume: 50, Issue:5, 2022
Controlled Activation of TRPV1 Channels on Microglia to Boost Their Autophagy for Clearance of Alpha-Synuclein and Enhance Therapy of Parkinson's Disease.Advanced materials (Deerfield Beach, Fla.), , Volume: 34, Issue:11, 2022
Fenofibrate promotes neuroprotection in a model of rotenone-induced Parkinson's disease.Behavioural pharmacology, , 12-01, Volume: 33, Issue:8, 2022
Therapeutics in the Pipeline Targeting Pharmacological reviews, , Volume: 74, Issue:1, 2022
Detection of α-Synuclein-Specific T Cells in Parkinson's Disease.Methods in molecular biology (Clifton, N.J.), , Volume: 2574, 2022
Homozygous CADPS2 Mutations Cause Neurodegenerative Disease with Lewy Body-like Pathology in Parrots.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:12, 2022
A double-hit in vivo model of GBA viral microRNA-mediated downregulation and human alpha-synuclein overexpression demonstrates nigrostriatal degeneration.Neurobiology of disease, , Volume: 163, 2022
Exploring the link between GBA1 mutations and Dementia with Lewy bodies, A mini-review.Neuroscience and biobehavioral reviews, , Volume: 141, 2022
Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A): Could It Be a Promising Biomarker and Therapeutic Target in Parkinson's Disease?Molecular neurobiology, , Volume: 59, Issue:2, 2022
Phosphorylated α-synuclein in diluted human serum as a biomarker for Parkinson's disease.Biomedical journal, , Volume: 45, Issue:6, 2022
Phosphorylation of the aggregate-forming protein alpha-synuclein on serine-129 inhibits its DNA-bending properties.The Journal of biological chemistry, , Volume: 298, Issue:2, 2022
Neuropathology of the Basal Ganglia in SNCA Transgenic Rat Model of Parkinson's Disease: Involvement of Parvalbuminergic Interneurons and Glial-Derived Neurotropic Factor.International journal of molecular sciences, , Sep-04, Volume: 23, Issue:17, 2022
Post-COVID-19 Parkinsonism and Parkinson's Disease Pathogenesis: The Exosomal Cargo Hypothesis.International journal of molecular sciences, , Aug-28, Volume: 23, Issue:17, 2022
Inhibition of α-synuclein aggregation by MT101-5 is neuroprotective in mouse models of Parkinson's disease.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 154, 2022
Neuroinflammation in Parkinson's Disease and its Treatment Opportunities.Balkan medical journal, , 09-09, Volume: 39, Issue:5, 2022
Examination of Abnormal Alpha-synuclein Aggregates in the Enteric Neural Plexus in Patients with Ulcerative Colitis.Journal of gastrointestinal and liver diseases : JGLD, , 09-15, Volume: 31, Issue:3, 2022
A new strategy to reconcile amyloid cross-seeding and amyloid prevention in a binary system of α-synuclein fragmental peptide and hIAPP.Protein science : a publication of the Protein Society, , Volume: 31, Issue:2, 2022
Skeletal Muscle is a Source of α-Synuclein with a Sarcolemmal Non-Lipid Raft Distribution.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , Aug-25, Volume: 56, Issue:4, 2022
Role of NLRP3 Inflammasome in Parkinson's Disease and Therapeutic Considerations.Journal of Parkinson's disease, , Volume: 12, Issue:7, 2022
The Role of Amyloid-β, Tau, and α-Synuclein Proteins as Putative Blood Biomarkers in Patients with Cerebral Amyloid Angiopathy.Journal of Alzheimer's disease : JAD, , Volume: 89, Issue:3, 2022
Angiotensin converting enzyme inhibitor captopril prevents neuronal overexpression of amyloid-beta and alpha-synuclein in Drosophila melanogaster genetic models of neurodegenerative diseases.Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, , Jun-30, Volume: 37, Issue:1, 2022
Mechanisms of NLRP3 activation and pathology during neurodegeneration.The international journal of biochemistry & cell biology, , Volume: 151, 2022
Functional Cooperation of α-Synuclein and Tau Is Essential for Proper Corticogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 09-14, Volume: 42, Issue:37, 2022
NXP031 prevents dopaminergic neuronal loss and oxidative damage in the AAV-WT-α-synuclein mouse model of Parkinson's disease.PloS one, , Volume: 17, Issue:7, 2022
Exogenous Tetranectin Alleviates Pre-formed-fibrils-induced Synucleinopathies in SH-SY5Y Cells by Activating the Plasminogen Activation System.Neurochemical research, , Volume: 47, Issue:10, 2022
A small molecule toll-like receptor antagonist rescues α-synuclein fibril pathology.The Journal of biological chemistry, , Volume: 298, Issue:8, 2022
Implications of intracellular protein degradation pathways in Parkinson's disease and therapeutics.Journal of neuroscience research, , Volume: 100, Issue:10, 2022
Role of platelet in Parkinson's disease: Insights into pathophysiology & theranostic solutions.Ageing research reviews, , Volume: 80, 2022
[Advances in Parkinson's disease induced by α-synuclein transmitted through the gut-brain axis].Sheng wu gong cheng xue bao = Chinese journal of biotechnology, , Jun-25, Volume: 38, Issue:6, 2022
The roles of HSP40/DNAJ protein family in neurodegenerative diseases.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, , Nov-25, Volume: 51, Issue:5, 2022
Lysosomal functions and dysfunctions: Molecular and cellular mechanisms underlying Gaucher disease and its association with Parkinson disease.Advanced drug delivery reviews, , Volume: 187, 2022
Microglia in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
The Role of Cholesterol in α-Synuclein and Lewy Body Pathology in GBA1 Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:5, 2021
[European journal of nuclear medicine and molecular imaging, , Volume: 48, Issue:6, 2021
Not a piece of junk anymore: Pseudogene T04B2.1 performs non-conventional regulatory role and modulates aggregation of α- synuclein and β-amyloid proteins in C. elegans.Biochemical and biophysical research communications, , 02-05, Volume: 539, 2021
Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities.Cell death and differentiation, , Volume: 28, Issue:2, 2021
Reverse engineering Lewy bodies: how far have we come and how far can we go?Nature reviews. Neuroscience, , Volume: 22, Issue:2, 2021
α-Synuclein and neuronal membranes: Conformational flexibilities in health and disease.Chemistry and physics of lipids, , Volume: 235, 2021
From Posttranslational Modifications to Disease Phenotype: A Substrate Selection Hypothesis in Neurodegenerative Diseases.International journal of molecular sciences, , Jan-18, Volume: 22, Issue:2, 2021
α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 03-10, Volume: 41, Issue:10, 2021
Evolutionary conservation and divergence of the human brain transcriptome.Genome biology, , 01-29, Volume: 22, Issue:1, 2021
Prion Diseases: A Unique Transmissible Agent or a Model for Neurodegenerative Diseases?Biomolecules, , 02-02, Volume: 11, Issue:2, 2021
Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.Chemical reviews, , 02-24, Volume: 121, Issue:4, 2021
Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration.Molecular therapy : the journal of the American Society of Gene Therapy, , 05-05, Volume: 29, Issue:5, 2021
Electrochemical biosensors for biometal-protein interactions in neurodegenerative diseases.Biosensors & bioelectronics, , May-01, Volume: 179, 2021
LRRK2 Ablation Attenuates Αlpha-Synuclein-Induced Neuroinflammation Without Affecting Neurodegeneration or Neuropathology In Vivo.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 18, Issue:2, 2021
[Therapeutic strategy for Parkinson's disease: targeting zinc-binding protein in astrocytes].Nihon yakurigaku zasshi. Folia pharmacologica Japonica, , Volume: 156, Issue:2, 2021
Neural-Induced Human Adipose Tissue-Derived Stem Cells Conditioned Medium Ameliorates Rotenone-Induced Toxicity in SH-SY5Y Cells.International journal of molecular sciences, , Feb-26, Volume: 22, Issue:5, 2021
DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization.PLoS genetics, , Volume: 17, Issue:3, 2021
Alpha-Synuclein in the Regulation of Brain Endothelial and Perivascular Cells: Gaps and Future Perspectives.Frontiers in immunology, , Volume: 12, 2021
α-Synuclein-induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms.Science advances, , Volume: 7, Issue:11, 2021
Pathophysiology of Parkinson's disease: Mitochondria, alpha-synuclein and much more….Revue neurologique, , Volume: 177, Issue:3, 2021
Biosensors in Parkinson's disease.Clinica chimica acta; international journal of clinical chemistry, , Volume: 518, 2021
SGTA associates with intracellular aggregates in neurodegenerative diseases.Molecular brain, , 03-23, Volume: 14, Issue:1, 2021
Update on the association between alpha-synuclein and tau with mitochondrial dysfunction: Implications for Parkinson's disease.The European journal of neuroscience, , Volume: 53, Issue:9, 2021
SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration.Biochemical and biophysical research communications, , 05-21, Volume: 554, 2021
PGC-1s in the Spotlight with Parkinson's Disease.International journal of molecular sciences, , Mar-28, Volume: 22, Issue:7, 2021
Amyloid Structural Changes Studied by Infrared Microspectroscopy in Bigenic Cellular Models of Alzheimer's Disease.International journal of molecular sciences, , Mar-26, Volume: 22, Issue:7, 2021
Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein.Acta neuropathologica communications, , 04-08, Volume: 9, Issue:1, 2021
Parkinson's disease and the gut: Models of an emerging relationship.Acta biomaterialia, , 09-15, Volume: 132, 2021
The magnetic-nanoparticle-assisted sensitive detection of nitrated α-syn in blood based on a sensitizing electrochemical layer.Nanoscale, , May-06, Volume: 13, Issue:17, 2021
Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential.Acta neuropathologica, , Volume: 142, Issue:1, 2021
Proteasome Subunits Involved in Neurodegenerative Diseases.Archives of medical research, , Volume: 52, Issue:1, 2021
[no title available]Frontiers in cellular and infection microbiology, , Volume: 11, 2021
Insights into Lewy body disease from rare neurometabolic disorders.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 128, Issue:10, 2021
Four Common Late-Life Cognitive Trajectories Patterns Associate with Replicable Underlying Neuropathologies.Journal of Alzheimer's disease : JAD, , Volume: 82, Issue:2, 2021
Green Tea Epigallocatechin-3-gallate (EGCG) Targeting Protein Misfolding in Drug Discovery for Neurodegenerative Diseases.Biomolecules, , 05-20, Volume: 11, Issue:5, 2021
Biomarkers for neurodegenerative diseases.Nature medicine, , Volume: 27, Issue:6, 2021
LMK235, a small molecule inhibitor of HDAC4/5, protects dopaminergic neurons against neurotoxin- and α-synuclein-induced degeneration in cellular models of Parkinson's disease.Molecular and cellular neurosciences, , Volume: 115, 2021
Neuroprotective effect of selumetinib on acrolein-induced neurotoxicity.Scientific reports, , 06-14, Volume: 11, Issue:1, 2021
Remodeling of the Fibrillation Pathway of α-Synuclein by Interaction with Antimicrobial Peptide LL-III.Chemistry (Weinheim an der Bergstrasse, Germany), , Aug-16, Volume: 27, Issue:46, 2021
Protein Aggregation Landscape in Neurodegenerative Diseases: Clinical Relevance and Future Applications.International journal of molecular sciences, , Jun-02, Volume: 22, Issue:11, 2021
Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions.Acta neuropathologica communications, , 07-21, Volume: 9, Issue:1, 2021
Clustered regularly interspaced short palindromic repeats as an advanced treatment for Parkinson's disease.Brain and behavior, , Volume: 11, Issue:8, 2021
Ultrasensitive techniques and protein misfolding amplification assays for biomarker-guided reconceptualization of Alzheimer's and other neurodegenerative diseases.Expert review of neurotherapeutics, , Volume: 21, Issue:9, 2021
The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model.Nature communications, , 08-11, Volume: 12, Issue:1, 2021
Pure autonomic failure and the differential diagnosis of autonomic peripheral neuropathies.Current opinion in neurology, , 10-01, Volume: 34, Issue:5, 2021
Genome-wide screen identifies curli amyloid fibril as a bacterial component promoting host neurodegeneration.Proceedings of the National Academy of Sciences of the United States of America, , 08-24, Volume: 118, Issue:34, 2021
Roles of α‑synuclein in gastrointestinal microbiome dysbiosis‑related Parkinson's disease progression (Review).Molecular medicine reports, , Volume: 24, Issue:4, 2021
Microglia is associated with p-Tau aggregates in the olfactory bulb of patients with neurodegenerative diseases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 42, Issue:4, 2021
Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 41, Issue:5, 2021
Implementing Complementary Approaches to Shape the Mechanism of α-Synuclein Oligomerization as a Model of Amyloid Aggregation.Molecules (Basel, Switzerland), , Dec-24, Volume: 27, Issue:1, 2021
Ellagic Acid Prevents α-Synuclein Aggregation and Protects SH-SY5Y Cells from Aggregated α-Synuclein-Induced Toxicity via Suppression of Apoptosis and Activation of Autophagy.International journal of molecular sciences, , Dec-13, Volume: 22, Issue:24, 2021
Targeted proteolytic products of τ and α-synuclein in neurodegeneration.Essays in biochemistry, , 12-22, Volume: 65, Issue:7, 2021
Updates on the Genetics of Parkinson's Disease: Clinical Implications and Future Treatment.Acta neurologica Taiwanica, , Sep-30, Volume: 30(3), 2021
(De)stabilization of Alpha-Synuclein Fibrillary Aggregation by Charged and Uncharged Surfactants.International journal of molecular sciences, , Nov-19, Volume: 22, Issue:22, 2021
Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds.Acta neuropathologica communications, , 11-24, Volume: 9, Issue:1, 2021
Effects of the Toxic Metals Arsenite and Cadmium on α-Synuclein Aggregation In Vitro and in Cells.International journal of molecular sciences, , Oct-24, Volume: 22, Issue:21, 2021
[Neuroprotective treatment of idiopathic, genetic and atypical Parkinson's disease with alpha-synuclein-Pathology].Der Nervenarzt, , Volume: 92, Issue:12, 2021
Discovery of Hydroxybenzothiazole Urea Compounds as Multitargeted Agents Suppressing Major Cytotoxic Mechanisms in Neurodegenerative Diseases.ACS chemical neuroscience, , 11-17, Volume: 12, Issue:22, 2021
Evidence of distinct α-synuclein strains underlying disease heterogeneity.Acta neuropathologica, , Volume: 142, Issue:1, 2021
MicroRNA-7 Protects Against Neurodegeneration Induced by α-Synuclein Preformed Fibrils in the Mouse Brain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 18, Issue:4, 2021
Sharing is caring: The benefits of distributing protein aggregates among microglial networks.Neuron, , 10-20, Volume: 109, Issue:20, 2021
Astrocyte dysfunction in Parkinson's disease: from the perspectives of transmitted α-synuclein and genetic modulation.Translational neurodegeneration, , 10-18, Volume: 10, Issue:1, 2021
Microglia esprit de corps: Sharing the burden of eliminating toxic aggregates.Cell, , 09-30, Volume: 184, Issue:20, 2021
Is Multiple System Atrophy a Prion-like Disorder?International journal of molecular sciences, , Sep-18, Volume: 22, Issue:18, 2021
N-γ-(L-glutamyl)-L-selenomethionine shows neuroprotective effects against Parkinson's disease associated with SKN-1/Nrf2 and TRXR-1 in Caenorhabditis elegans.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 92, 2021
Alternative platelet activation pathways and their role in neurodegenerative diseases.Neurobiology of disease, , Volume: 159, 2021
Glucocerebrosidase dysfunction in neurodegenerative disease.Essays in biochemistry, , 12-22, Volume: 65, Issue:7, 2021
Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration.Nature communications, , 09-06, Volume: 12, Issue:1, 2021
Gut microbiota and metabolites of α-synuclein transgenic monkey models with early stage of Parkinson's disease.NPJ biofilms and microbiomes, , 09-02, Volume: 7, Issue:1, 2021
Role of Alcohol Drinking in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis.International journal of molecular sciences, , Mar-27, Volume: 21, Issue:7, 2020
Metformin protects rotenone-induced dopaminergic neurodegeneration by reducing lipid peroxidation.Pharmacological reports : PR, , Volume: 72, Issue:5, 2020
Protein transmission in neurodegenerative disease.Nature reviews. Neurology, , Volume: 16, Issue:4, 2020
Potential sources of interference with the highly sensitive detection and quantification of alpha-synuclein seeds by qRT-QuIC.FEBS open bio, , Volume: 10, Issue:5, 2020
The role of tissue biopsy as a biomarker in REM sleep behavior disorder.Sleep medicine reviews, , Volume: 51, 2020
α-Synuclein Exhibits Differential Membrane Perturbation, Nucleation, and TLR2 Binding through Its Secondary Structure.ACS chemical neuroscience, , 12-16, Volume: 11, Issue:24, 2020
Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration.Nature communications, , 03-13, Volume: 11, Issue:1, 2020
Cerebrospinal fluid α-synuclein predicts neurodegeneration and clinical progression in non-demented elders.Translational neurodegeneration, , 11-23, Volume: 9, Issue:1, 2020
Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing α-synuclein and immune activation of Parkinson's disease.Science advances, , Volume: 6, Issue:50, 2020
Therapeutic genetic variation revealed in diverse Hsp104 homologs.eLife, , 12-15, Volume: 9, 2020
On the role of the cellular prion protein in the uptake and signaling of pathological aggregates in neurodegenerative diseases.Prion, , Volume: 14, Issue:1, 2020
Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases.Journal of neuropathology and experimental neurology, , 04-01, Volume: 79, Issue:4, 2020
The Antiaggregative and Antiamyloidogenic Properties of Nanoparticles: A Promising Tool for the Treatment and Diagnostics of Neurodegenerative Diseases.Oxidative medicine and cellular longevity, , Volume: 2020, 2020
Evaluating the Effects of Grain of Isogenic Wheat Lines Differing in the Content of Anthocyanins in Mouse Models of Neurodegenerative Disorders.Nutrients, , Dec-18, Volume: 12, Issue:12, 2020
A Curcumin Derivative Activates TFEB and Protects Against Parkinsonian Neurotoxicity International journal of molecular sciences, , Feb-22, Volume: 21, Issue:4, 2020
The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration.Proceedings of the National Academy of Sciences of the United States of America, , 03-03, Volume: 117, Issue:9, 2020
Toxic oligomers of the amyloidogenic HypF-N protein form pores in mitochondrial membranes.Scientific reports, , 10-20, Volume: 10, Issue:1, 2020
Developmental deficits and early signs of neurodegeneration revealed by PD patient derived dopamine neurons.Stem cell research, , Volume: 49, 2020
Natural and Synthetic Derivatives of Hydroxycinnamic Acid Modulating the Pathological Transformation of Amyloidogenic Proteins.Molecules (Basel, Switzerland), , Oct-12, Volume: 25, Issue:20, 2020
Double-stranded RNA-induced dopaminergic neuronal loss in the substantia nigra in the presence of Mac1 receptor.Biochemical and biophysical research communications, , 12-17, Volume: 533, Issue:4, 2020
[Emerging Disease-modifying Strategies Targeting α-synuclein in Parkinson's Disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:2, 2020
Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns.Journal of neuropathology and experimental neurology, , 11-01, Volume: 79, Issue:11, 2020
Intracerebral seeding of amyloid-β and tau pathology in mice: Factors underlying prion-like spreading and comparisons with α-synuclein.Neuroscience and biobehavioral reviews, , Volume: 112, 2020
Potential therapeutic role of fibroblast growth factor 21 in neurodegeneration: Evidence for ameliorating parkinsonism via silent information regulator 2 homolog 1 and implication for gene therapy.Neuropharmacology, , 12-15, Volume: 181, 2020
Targeting α-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance.Translational neurodegeneration, , 09-24, Volume: 9, Issue:1, 2020
Asparagine endopeptidase inhibitor protects against fenpropathrin-induced neurodegeneration via suppressing α-synuclein aggregation and neuroinflammation.European journal of pharmacology, , Dec-05, Volume: 888, 2020
Classifications of Neurodegenerative Disorders Using a Multiplex Blood Biomarkers-Based Machine Learning Model.International journal of molecular sciences, , Sep-21, Volume: 21, Issue:18, 2020
The role of the cellular prion protein in the uptake and toxic signaling of pathological neurodegenerative aggregates.Progress in molecular biology and translational science, , Volume: 175, 2020
Epitope region identification challenges of intrinsically disordered proteins in neurodegenerative diseases: Secondary structure dependence of α-synuclein on simulation techniques and force field parameters.Chemical biology & drug design, , Volume: 96, Issue:1, 2020
O-GlcNAcylation inhibits the oligomerization of alpha-synuclein by declining intermolecular hydrogen bonds through a steric effect.Physical biology, , 12-01, Volume: 18, Issue:1, 2020
Mangosteen Pericarp and Its Bioactive Xanthones: Potential Therapeutic Value in Alzheimer's Disease, Parkinson's Disease, and Depression with Pharmacokinetic and Safety Profiles.International journal of molecular sciences, , Aug-27, Volume: 21, Issue:17, 2020
Prion-like properties of assembled TDP-43.Current opinion in neurobiology, , Volume: 61, 2020
Defining the Protein Seeds of Neurodegeneration using Real-Time Quaking-Induced Conversion Assays.Biomolecules, , 08-25, Volume: 10, Issue:9, 2020
Interactions between Soluble Species of β-Amyloid and α-Synuclein Promote Oligomerization while Inhibiting Fibrillization.Biochemistry, , 02-04, Volume: 59, Issue:4, 2020
PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins.Acta neuropathologica, , Volume: 139, Issue:3, 2020
Iron-responsive-like elements and neurodegenerative ferroptosis.Learning & memory (Cold Spring Harbor, N.Y.), , Volume: 27, Issue:9, 2020
In Vitro Conversion Assays Diagnostic for Neurodegenerative Proteinopathies.The journal of applied laboratory medicine, , 01-01, Volume: 5, Issue:1, 2020
Discoidin Domain Receptor 1 is a therapeutic target for neurodegenerative diseases.Human molecular genetics, , 10-10, Volume: 29, Issue:17, 2020
Somatic mutations in neurodegeneration: An update.Neurobiology of disease, , Volume: 144, 2020
Tau and Alpha Synuclein Synergistic Effect in Neurodegenerative Diseases: When the Periphery Is the Core.International journal of molecular sciences, , Jul-16, Volume: 21, Issue:14, 2020
Endosomal-Lysosomal Processing of Neurodegeneration-Associated Proteins in Astrocytes.International journal of molecular sciences, , Jul-21, Volume: 21, Issue:14, 2020
Ropinirole silver nanocomposite attenuates neurodegeneration in the transgenic Drosophila melanogaster model of Parkinson's disease.Neuropharmacology, , 10-15, Volume: 177, 2020
General Aggregation-Induced Emission Probes for Amyloid Inhibitors with Dual Inhibition Capacity against Amyloid β-Protein and α-Synuclein.ACS applied materials & interfaces, , Jul-15, Volume: 12, Issue:28, 2020
Fasudil Promotes α-Synuclein Clearance in an AAV-Mediated α-Synuclein Rat Model of Parkinson's Disease by Autophagy Activation.Journal of Parkinson's disease, , Volume: 10, Issue:3, 2020
Crosstalk Between Alpha-Synuclein and Other Human and Non-Human Amyloidogenic Proteins: Consequences for Amyloid Formation in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 10, Issue:3, 2020
Advances in the development of imaging probes and aggregation inhibitors for alpha-synuclein.Acta pharmacologica Sinica, , Volume: 41, Issue:4, 2020
What is strain in neurodegenerative diseases?Cellular and molecular life sciences : CMLS, , Volume: 77, Issue:4, 2020
Experimental models of prion-like protein propagation.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 40, Issue:5, 2020
N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of Their Oligomers by the Proteasome Holoenzyme.Journal of molecular biology, , 01-17, Volume: 432, Issue:2, 2020
The interaction of α-synuclein and Tau: A molecular conspiracy in neurodegeneration?Seminars in cell & developmental biology, , Volume: 99, 2020
A systems biology approach for studying neurodegenerative diseases.Drug discovery today, , Volume: 25, Issue:7, 2020
The emerging role of α-synuclein truncation in aggregation and disease.The Journal of biological chemistry, , 07-24, Volume: 295, Issue:30, 2020
Ubiquitin biology in neurodegenerative disorders: From impairment to therapeutic strategies.Ageing research reviews, , Volume: 61, 2020
Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates.International journal of molecular sciences, , May-10, Volume: 21, Issue:9, 2020
Cell-to-Cell Transmission of Tau and α-Synuclein.Trends in molecular medicine, , Volume: 26, Issue:10, 2020
Immunotherapies for Aging-Related Neurodegenerative Diseases-Emerging Perspectives and New Targets.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 17, Issue:3, 2020
C. elegans as a Model for Synucleinopathies and Other Neurodegenerative Diseases: Tools and Techniques.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
Single-Molecule FRET Detection of Early-Stage Conformations in α-Synuclein Aggregation.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
α-Synuclein and astrocytes: tracing the pathways from homeostasis to neurodegeneration in Lewy body disease.Acta neuropathologica, , Volume: 138, Issue:1, 2019
Cerebrospinal Fluid and Plasma Biomarkers in Neurodegenerative Diseases.Journal of Alzheimer's disease : JAD, , Volume: 68, Issue:1, 2019
Parkinson's disease-linked Proceedings of the National Academy of Sciences of the United States of America, , 03-19, Volume: 116, Issue:12, 2019
Modulation of Disordered Proteins with a Focus on Neurodegenerative Diseases and Other Pathologies.International journal of molecular sciences, , Mar-15, Volume: 20, Issue:6, 2019
Clinical and neuropathological differences between Parkinson's disease, Parkinson's disease dementia and dementia with Lewy bodies - current issues and future directions.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Lysosomal enzyme activities as possible CSF biomarkers of synucleinopathies.Clinica chimica acta; international journal of clinical chemistry, , Volume: 495, 2019
AAA+ Protein-Based Technologies to Counter Neurodegenerative Disease.Biophysical journal, , 04-23, Volume: 116, Issue:8, 2019
Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.Nature communications, , 04-18, Volume: 10, Issue:1, 2019
Neurodegenerative Disease-Related Proteins within the Epidermal Layer of the Human Skin.Journal of Alzheimer's disease : JAD, , Volume: 69, Issue:2, 2019
Inflammasomes in neuroinflammatory and neurodegenerative diseases.EMBO molecular medicine, , Volume: 11, Issue:6, 2019
Thymoquinone prevents neurodegeneration against MPTP in vivo and modulates α-synuclein aggregation in vitro.Neurochemistry international, , Volume: 128, 2019
Viral mimetic priming enhances α-synuclein-induced degeneration: Implications for Parkinson's disease.Brain, behavior, and immunity, , Volume: 80, 2019
Nitroalkylation of α-Synuclein by Nitro-Oleic Acid: Implications for Parkinson's Disease.Advances in experimental medicine and biology, , Volume: 1127, 2019
Early impairment of epigenetic pattern in neurodegeneration: Additional mechanisms behind pyrethroid toxicity.Experimental gerontology, , Volume: 124, 2019
Patient-specific pluripotent stem cell-based Parkinson's disease models showing endogenous alpha-synuclein aggregation.BMB reports, , Volume: 52, Issue:6, 2019
Simultaneous tonic and phasic REM sleep without atonia best predicts early phenoconversion to neurodegenerative disease in idiopathic REM sleep behavior disorder.Sleep, , 09-06, Volume: 42, Issue:9, 2019
The Role of Antibodies and Their Receptors in Protection Against Ordered Protein Assembly in Neurodegeneration.Frontiers in immunology, , Volume: 10, 2019
[Exosomes and their roles in neurodegenerative diseases: from pathogenic, diagnostic and therapeutical perspectives].Sheng li xue bao : [Acta physiologica Sinica], , Jun-25, Volume: 71, Issue:3, 2019
[Prion-like Propagation of Pathological α-Synuclein in Vivo].Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, , Volume: 139, Issue:7, 2019
[Prion and Prion-like Proteins].Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, , Volume: 139, Issue:7, 2019
Cellular models of alpha-synuclein toxicity and aggregation.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Glial α-synuclein promotes neurodegeneration characterized by a distinct transcriptional program in vivo.Glia, , Volume: 67, Issue:10, 2019
Neuronal Proteins as Targets of 3-Hydroxykynurenine: Implications in Neurodegenerative Diseases.ACS chemical neuroscience, , 08-21, Volume: 10, Issue:8, 2019
Mitochondrial degradation of amyloidogenic proteins - A new perspective for neurodegenerative diseases.Progress in neurobiology, , Volume: 181, 2019
Rifampicin and Its Derivative Rifampicin Quinone Reduce Microglial Inflammatory Responses and Neurodegeneration Induced In Vitro by α-Synuclein Fibrillary Aggregates.Cells, , 07-25, Volume: 8, Issue:8, 2019
Relationship Between Tau, β Amyloid and α-Synuclein Pathologies.Advances in experimental medicine and biology, , Volume: 1184, 2019
Dynamic behaviors of α-synuclein and tau in the cellular context: New mechanistic insights and therapeutic opportunities in neurodegeneration.Neurobiology of disease, , Volume: 132, 2019
Local vulnerability and global connectivity jointly shape neurodegenerative disease propagation.PLoS biology, , Volume: 17, Issue:11, 2019
Small molecule modulator of aggrephagy regulates neuroinflammation to curb pathogenesis of neurodegeneration.EBioMedicine, , Volume: 50, 2019
Progressive supranuclear palsy, multiple system atrophy and corticobasal degeneration.Handbook of clinical neurology, , Volume: 165, 2019
[The Propagation Hypothesis of Prion-like Protein Agregates in Neurodegenerative Diseases].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 71, Issue:11, 2019
Prion-like propagation of α-synuclein in neurodegenerative diseases.Progress in molecular biology and translational science, , Volume: 168, 2019
PET imaging of the influence of physiological and pathological α-synuclein on dopaminergic and serotonergic neurotransmission in mouse models.CNS neuroscience & therapeutics, , Volume: 25, Issue:1, 2019
Ammon's Horn 2 (CA2) of the Hippocampus: A Long-Known Region with a New Potential Role in Neurodegeneration.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, , Volume: 25, Issue:2, 2019
Exploring the Peripheral Initiation of Parkinson's Disease in Animal Models.Neuron, , 08-21, Volume: 103, Issue:4, 2019
Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration.Brain pathology (Zurich, Switzerland), , Volume: 29, Issue:1, 2019
Fluid-based proteomics targeted on pathophysiological processes and pathologies in neurodegenerative diseases.Journal of neurochemistry, , Volume: 151, Issue:4, 2019
Mechanistic Insight into the Binding Profile of DCVJ and α-Synuclein Fibril Revealed by Multiscale Simulations.ACS chemical neuroscience, , 01-16, Volume: 10, Issue:1, 2019
Protein-DNA interaction: One step closer to understanding the mechanism of neurodegeneration.Journal of neuroscience research, , Volume: 97, Issue:4, 2019
Pα-syn* mitotoxicity is linked to MAPK activation and involves tau phosphorylation and aggregation at the mitochondria.Neurobiology of disease, , Volume: 124, 2019
Disease model organism for Parkinson disease: Drosophila melanogaster.BMB reports, , Volume: 52, Issue:4, 2019
Cell Responses to Extracellular α-Synuclein.Molecules (Basel, Switzerland), , 01-15, Volume: 24, Issue:2, 2019
Glycation of α-synuclein amplifies the binding with glyceraldehyde-3-phosphate dehydrogenase.International journal of biological macromolecules, , Apr-15, Volume: 127, 2019
New tricks of prolyl oligopeptidase inhibitors - A common drug therapy for several neurodegenerative diseases.Biochemical pharmacology, , Volume: 161, 2019
The prion-like spreading of α-synuclein: From in vitro to in vivo models of Parkinson's disease.Ageing research reviews, , Volume: 50, 2019
Internalization, axonal transport and release of fibrillar forms of alpha-synuclein.Neurobiology of disease, , Volume: 109, Issue:Pt B, 2018
Distinct α-Synuclein strains and implications for heterogeneity among α-Synucleinopathies.Neurobiology of disease, , Volume: 109, Issue:Pt B, 2018
Mitochondrial Dynamics and Proteins Related to Neurodegenerative Diseases.Current protein & peptide science, , Volume: 19, Issue:9, 2018
Effects of mild running on substantia nigra during early neurodegeneration.Journal of sports sciences, , Volume: 36, Issue:12, 2018
Molecular mechanisms of the co-deposition of multiple pathological proteins in neurodegenerative diseases.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 38, Issue:1, 2018
Targeting of Disordered Proteins by Small Molecules in Neurodegenerative Diseases.Handbook of experimental pharmacology, , Volume: 245, 2018
A critical review of the prion hypothesis of human synucleinopathies.Cell and tissue research, , Volume: 373, Issue:1, 2018
Oligomer-prone E57K-mutant alpha-synuclein exacerbates integration deficit of adult hippocampal newborn neurons in transgenic mice.Brain structure & function, , Volume: 223, Issue:3, 2018
RTP801 is a critical factor in the neurodegeneration process of A53T α-synuclein in a mouse model of Parkinson's disease under chronic restraint stress.British journal of pharmacology, , Volume: 175, Issue:4, 2018
Microarray analysis of an synthetic α-synuclein induced cellular model reveals the expression profile of long non-coding RNA in Parkinson's disease.Brain research, , Jan-01, Volume: 1678, 2018
Idiopathic REM sleep behaviour disorder and neurodegeneration - an update.Nature reviews. Neurology, , Volume: 14, Issue:1, 2018
The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases.Journal of neuropathology and experimental neurology, , Jan-01, Volume: 77, Issue:1, 2018
Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term.Acta neuropathologica, , Volume: 135, Issue:1, 2018
Toxic properties of microsome-associated alpha-synuclein species in mouse primary neurons.Neurobiology of disease, , Volume: 111, 2018
Combined Active Humoral and Cellular Immunization Approaches for the Treatment of Synucleinopathies.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 01-24, Volume: 38, Issue:4, 2018
Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach.Brain : a journal of neurology, , 02-01, Volume: 141, Issue:2, 2018
Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice.Proceedings of the National Academy of Sciences of the United States of America, , 02-13, Volume: 115, Issue:7, 2018
Le hazard ou la nécessité? Comorbid pathologies of neurodegenerative diseases.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 38, Issue:1, 2018
Minimal neuropathologic diagnosis for brain banking in the normal middle-aged and aged brain and in neurodegenerative disorders.Handbook of clinical neurology, , Volume: 150, 2018
Cre-dependent AAV vectors for highly targeted expression of disease-related proteins and neurodegeneration in the substantia nigra.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 32, Issue:8, 2018
Single-chain Fv Antibodies for Targeting Neurodegenerative Diseases.CNS & neurological disorders drug targets, , Volume: 17, Issue:9, 2018
The dopamine transporter: An unrecognized nexus for dysfunctional peripheral immunity and signaling in Parkinson's Disease.Brain, behavior, and immunity, , Volume: 70, 2018
Cx3cr1-deficiency exacerbates alpha-synuclein-A53T induced neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease.Glia, , Volume: 66, Issue:8, 2018
Influence of Drug-Carrier Polymers on Alpha-Synucleinopathies: A Neglected Aspect in New Therapies Development.BioMed research international, , Volume: 2018, 2018
Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology.Acta neuropathologica, , Volume: 136, Issue:3, 2018
Chaperone AMPylation modulates aggregation and toxicity of neurodegenerative disease-associated polypeptides.Proceedings of the National Academy of Sciences of the United States of America, , 05-29, Volume: 115, Issue:22, 2018
[Targeting Transcellular Transport of α-Synuclein for Developing Disease-Modifying Therapies for Synucleinopathy].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 70, Issue:5, 2018
Linking Neuroinflammation and Neurodegeneration in Parkinson's Disease.Journal of immunology research, , Volume: 2018, 2018
Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated.Brain : a journal of neurology, , 07-01, Volume: 141, Issue:7, 2018
α-Synuclein and Polyunsaturated Fatty Acids: Molecular Basis of the Interaction and Implication in Neurodegeneration.Molecules (Basel, Switzerland), , Jun-25, Volume: 23, Issue:7, 2018
The sulfation code for propagation of neurodegeneration.The Journal of biological chemistry, , 07-06, Volume: 293, Issue:27, 2018
Mitochondrial dysfunction and neurodegenerative proteinopathies: mechanisms and prospects for therapeutic intervention.Biochemical Society transactions, , 08-20, Volume: 46, Issue:4, 2018
α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies.Proceedings of the National Academy of Sciences of the United States of America, , 07-24, Volume: 115, Issue:30, 2018
Evolvability and Neurodegenerative Disease: Antagonistic Pleiotropy Phenomena Derived from Amyloid Aggregates.Journal of Parkinson's disease, , Volume: 8, Issue:3, 2018
Mitochondrial dysfunction in protein conformational disorders.Journal of genetics, , Volume: 97, Issue:3, 2018
Model Senescent Microglia Induce Disease Related Changes in α-Synuclein Expression and Activity.Biomolecules, , 08-01, Volume: 8, Issue:3, 2018
Therapeutic implications of how TNF links apolipoprotein E, phosphorylated tau, α-synuclein, amyloid-β and insulin resistance in neurodegenerative diseases.British journal of pharmacology, , Volume: 175, Issue:20, 2018
Selective autophagy as a potential therapeutic target for neurodegenerative disorders.The Lancet. Neurology, , Volume: 17, Issue:9, 2018
BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT.JCI insight, , 08-23, Volume: 3, Issue:16, 2018
Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease.Acta neuropathologica, , Volume: 136, Issue:6, 2018
Ceftriaxone Treatment for Neuronal Deficits: A Histological and MEMRI Study in a Rat Model of Dementia with Lewy Bodies.Behavioural neurology, , Volume: 2018, 2018
Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson's disease.Journal of neuroinflammation, , Aug-30, Volume: 15, Issue:1, 2018
A53T Mutant Alpha-Synuclein Induces Tau-Dependent Postsynaptic Impairment Independently of Neurodegenerative Changes.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 11-07, Volume: 38, Issue:45, 2018
Predicting the location of the non-local contacts in α-synuclein.Biochimica et biophysica acta. Proteins and proteomics, , Volume: 1866, Issue:12, 2018
Isolated nigral degeneration without pathological protein aggregation in autopsied brains with LRRK2 p.R1441H homozygous and heterozygous mutations.Acta neuropathologica communications, , 10-17, Volume: 6, Issue:1, 2018
Bicyclic bis-heteroaryl derivatives as inhibitors of the α-synuclein protein: a patent evaluation of WO2018138088A1.Expert opinion on therapeutic patents, , Volume: 28, Issue:12, 2018
Sensing α-Synuclein From the Outside via the Prion Protein: Implications for Neurodegeneration.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:11, 2018
Prions and Non-infectious Amyloids of Mammals - Similarities and Differences.Biochemistry. Biokhimiia, , Volume: 83, Issue:10, 2018
Alpha-synuclein alters differently gene expression of Sirts, PARPs and other stress response proteins: implications for neurodegenerative disorders.Molecular neurobiology, , Volume: 55, Issue:1, 2018
Non-Amyloid PET Imaging Biomarkers for Neurodegeneration: Focus on Tau, Alpha-Synuclein and Neuroinflammation.Current Alzheimer research, , Volume: 14, Issue:2, 2017
Triptolide Promotes the Clearance of α-Synuclein by Enhancing Autophagy in Neuronal Cells.Molecular neurobiology, , Volume: 54, Issue:3, 2017
Protein aggregation and neurodegeneration in prototypical neurodegenerative diseases: Examples of amyloidopathies, tauopathies and synucleinopathies.Progress in neurobiology, , Volume: 155, 2017
Structural variants in SNCA gene and the implication to synucleinopathies.Current opinion in genetics & development, , Volume: 44, 2017
Cerebrospinal Fluid Biomarkers of Neurodegeneration Are Decreased or Normal in Narcolepsy.Sleep, , Jan-01, Volume: 40, Issue:1, 2017
Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.Brain : a journal of neurology, , May-01, Volume: 140, Issue:5, 2017
Interactions of pathological proteins in neurodegenerative diseases.Acta neuropathologica, , Volume: 134, Issue:2, 2017
Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.Neurochemistry international, , Volume: 109, 2017
Therapeutic implication of autophagy in neurodegenerative diseases.BMB reports, , Volume: 50, Issue:7, 2017
Validation of electrochemiluminescence assays for highly sensitive and reproducible quantification of α-synuclein in cerebrospinal fluid.Bioanalysis, , Volume: 9, Issue:8, 2017
Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity.Molecular neurodegeneration, , 05-29, Volume: 12, Issue:1, 2017
Novel approach for accurate tissue-based protein colocalization and proximity microscopy.Scientific reports, , 06-01, Volume: 7, Issue:1, 2017
α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration.Neurobiology of disease, , Volume: 105, 2017
Medicinal chemistry advances in neurodegenerative disease therapy: part 2.Future medicinal chemistry, , Volume: 9, Issue:10, 2017
Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain.Acta neuropathologica communications, , 06-23, Volume: 5, Issue:1, 2017
Human cyclophilin 40 unravels neurotoxic amyloids.PLoS biology, , Volume: 15, Issue:6, 2017
Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species.BMC biology, , 07-03, Volume: 15, Issue:1, 2017
Physico-Pathologic Mechanisms Involved in Neurodegeneration: Misfolded Protein-Plasma Membrane Interactions.Neuron, , Jul-05, Volume: 95, Issue:1, 2017
Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form.Neurobiology of disease, , Volume: 106, 2017
Quantitative proteomics in A30P*A53T α-synuclein transgenic mice reveals upregulation of Sel1l.PloS one, , Volume: 12, Issue:8, 2017
Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates.Scientific reports, , 08-09, Volume: 7, Issue:1, 2017
Small-molecule PET Tracers for Imaging Proteinopathies.Seminars in nuclear medicine, , Volume: 47, Issue:5, 2017
MultiTEP platform-based DNA vaccines for alpha-synucleinopathies: preclinical evaluation of immunogenicity and therapeutic potency.Neurobiology of aging, , Volume: 59, 2017
E46K α-synuclein pathological mutation causes cell-autonomous toxicity without altering protein turnover or aggregation.Proceedings of the National Academy of Sciences of the United States of America, , 09-26, Volume: 114, Issue:39, 2017
Protein arginylation targets alpha synuclein, facilitates normal brain health, and prevents neurodegeneration.Scientific reports, , 09-12, Volume: 7, Issue:1, 2017
Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration.Nature neuroscience, , Volume: 20, Issue:11, 2017
Phosphoproteome-based kinase activity profiling reveals the critical role of MAP2K2 and PLK1 in neuronal autophagy.Autophagy, , Volume: 13, Issue:11, 2017
Gene Expression Analysis Reveals Genes Common to Cerebral Malaria and Neurodegenerative Disorders.The Journal of infectious diseases, , 09-15, Volume: 216, Issue:6, 2017
Glycation, Glycolysis, and Neurodegenerative Diseases: Is There Any Connection?Biochemistry. Biokhimiia, , Volume: 82, Issue:8, 2017
Getting in charge of β-synuclein fibrillation.The Journal of biological chemistry, , 09-29, Volume: 292, Issue:39, 2017
Prion-like transmission of α-synuclein pathology in the context of an NFL null background.Neuroscience letters, , Nov-20, Volume: 661, 2017
Concepts and classification of neurodegenerative diseases.Handbook of clinical neurology, , Volume: 145, 2017
Alpha-synucleinopathies.Handbook of clinical neurology, , Volume: 145, 2017
Comparison of the in vivo induction and transmission of α-synuclein pathology by mutant α-synuclein fibril seeds in transgenic mice.Human molecular genetics, , 12-15, Volume: 26, Issue:24, 2017
Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases.Molecular neurodegeneration, , 10-23, Volume: 12, Issue:1, 2017
Anti-Parkinsonian effects of β-amyrin are regulated via LGG-1 involved autophagy pathway in Caenorhabditis elegans.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Dec-01, Volume: 36, 2017
Proteinopathies and OXPHOS dysfunction in neurodegenerative diseases.The Journal of cell biology, , 12-04, Volume: 216, Issue:12, 2017
Endogenous Alpha-Synuclein Protein Analysis from Human Brain Tissues Using Single-Molecule Pull-Down Assay.Analytical chemistry, , 12-19, Volume: 89, Issue:24, 2017
Focal Unilateral Traumatic brain injury Causes Delayed Neurodegenerative Changes in the Brain of Rats.Bulletin of experimental biology and medicine, , Volume: 164, Issue:2, 2017
Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation.Biochemical Society transactions, , 02-08, Volume: 45, Issue:1, 2017
Tell me your neighbors, and I will tell you what you are.Science translational medicine, , 02-08, Volume: 9, Issue:376, 2017
Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species.Scientific reports, , 02-03, Volume: 7, 2017
Auxilin Underlies Progressive Locomotor Deficits and Dopaminergic Neuron Loss in a Drosophila Model of Parkinson's Disease.Cell reports, , 01-31, Volume: 18, Issue:5, 2017
Diagnosis, disease notification, and management of rapid eye movement (REM) sleep behavior disorder.Rinsho shinkeigaku = Clinical neurology, , 02-25, Volume: 57, Issue:2, 2017
Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways.Cell systems, , 02-22, Volume: 4, Issue:2, 2017
Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy.Acta neuropathologica communications, , 01-13, Volume: 5, Issue:1, 2017
Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice.Molecular neurodegeneration, , 01-03, Volume: 12, Issue:1, 2017
Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation.Brain research bulletin, , Volume: 133, 2017
Extracts from two ubiquitous Mediterranean plants ameliorate cellular and animal models of neurodegenerative proteinopathies.Neuroscience letters, , 01-18, Volume: 638, 2017
Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders.Pharmacology & therapeutics, , Volume: 172, 2017
Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases.EMBO molecular medicine, , Volume: 9, Issue:1, 2017
Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils.Journal of virology, , Jan-15, Volume: 91, Issue:2, 2017
Treatments and compositions targeting α-synuclein: a patent review (2010-2016).Expert opinion on therapeutic patents, , Volume: 27, Issue:4, 2017
Hederagenin and α-hederin promote degradation of proteins in neurodegenerative diseases and improve motor deficits in MPTP-mice.Pharmacological research, , Volume: 115, 2017
Cellular Models for the Study of Prions.Cold Spring Harbor perspectives in medicine, , Feb-01, Volume: 7, Issue:2, 2017
Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration.Brain : a journal of neurology, , Volume: 140, Issue:2, 2017
Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease.Acta neuropathologica communications, , 06-23, Volume: 4, Issue:1, 2016
Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.Neuron, , 07-06, Volume: 91, Issue:1, 2016
Engineering therapeutic protein disaggregases.Molecular biology of the cell, , 05-15, Volume: 27, Issue:10, 2016
Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 05-04, Volume: 36, Issue:18, 2016
A First Tetraplex Assay for the Simultaneous Quantification of Total α-Synuclein, Tau, β-Amyloid42 and DJ-1 in Human Cerebrospinal Fluid.PloS one, , Volume: 11, Issue:4, 2016
High expression of α-synuclein in damaged mitochondria with PLA2G6 dysfunction.Acta neuropathologica communications, , Mar-30, Volume: 4, 2016
[Assemblies of alpha-synuclein: do different strains exist?].Medecine sciences : M/S, , Volume: 32, Issue:3, 2016
A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration.Nature reviews. Neuroscience, , Volume: 17, Issue:4, 2016
Interferon-β may ameliorate synucleinopathy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:4, 2016
Protein Partners of α-Synuclein in Health and Disease.Brain pathology (Zurich, Switzerland), , Volume: 26, Issue:3, 2016
Exocytosis and Spreading of Normal and Aberrant α-Synuclein.Brain pathology (Zurich, Switzerland), , Volume: 26, Issue:3, 2016
α-Synuclein in Neurodegeneration-A Good Protein that may go Bad.Brain pathology (Zurich, Switzerland), , Volume: 26, Issue:3, 2016
ɑ-Synuclein strains and the variable pathologies of synucleinopathies.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
(123)I-meta-iodobenzylguanidine (MIBG) cardiac scintigraphy in α-synucleinopathies.Ageing research reviews, , Volume: 30, 2016
Editorial overview: Neurobiology of disease.Current opinion in neurobiology, , Volume: 36, 2016
Lysines, Achilles' heel in alpha-synuclein conversion to a deadly neuronal endotoxin.Ageing research reviews, , Volume: 26, 2016
Immunotherapeutic Approaches Targeting Amyloid-β, α-Synuclein, and Tau for the Treatment of Neurodegenerative Disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 13, Issue:1, 2016
Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein.Methods in molecular biology (Clifton, N.J.), , Volume: 1345, 2016
Cdk5 at crossroads of protein oligomerization in neurodegenerative diseases: facts and hypotheses.Journal of neurochemistry, , Volume: 136, Issue:2, 2016
Alpha-synuclein propagation: New insights from animal models.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Activation of Mitochondrial Complex II-Dependent Respiration Is Beneficial for α-Synucleinopathies.Molecular neurobiology, , Volume: 53, Issue:7, 2016
The utility of α-synuclein as biofluid marker in neurodegenerative diseases: a systematic review of the literature.Biomarkers in medicine, , Volume: 10, Issue:1, 2016
New insights into cellular α-synuclein homeostasis in health and disease.Current opinion in neurobiology, , Volume: 36, 2016
Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Glia and alpha-synuclein in neurodegeneration: A complex interaction.Neurobiology of disease, , Volume: 85, 2016
Amelioration of neuronal cell death in a spontaneous obese rat model by dietary restriction through modulation of ubiquitin proteasome system.The Journal of nutritional biochemistry, , Volume: 33, 2016
Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease.Science translational medicine, , 12-07, Volume: 8, Issue:368, 2016
[The Prion-like Mechanism in Neurodegenerative Diseases-Current Studies and Future Prospects].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 68, Issue:10, 2016
Shared and Distinct Patterns of Oligodendroglial Response in α-Synucleinopathies and Tauopathies.Journal of neuropathology and experimental neurology, , 12-01, Volume: 75, Issue:12, 2016
Lysosomal storage disorders: 4 big questions.Nature, , 09-22, Volume: 537, Issue:7621, 2016
Neurodegenerative disorders: Novel CSF assay for α-synucleinopathies.Nature reviews. Neurology, , Volume: 12, Issue:10, 2016
Alpha-Synuclein, a Novel Viral Restriction Factor Hiding in Plain Sight.DNA and cell biology, , Volume: 35, Issue:11, 2016
[Iron accumulation and neurodegenerative diseases].Nihon rinsho. Japanese journal of clinical medicine, , Volume: 74, Issue:7, 2016
Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 07-20, Volume: 36, Issue:29, 2016
From the Cover: Arsenic Induces Accumulation of α-Synuclein: Implications for Synucleinopathies and Neurodegeneration.Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 153, Issue:2, 2016
Is age-related failure of metabolic reprogramming a principal mediator in idiopathic Parkinson's disease? Implications for treatment and inverse cancer risk.Medical hypotheses, , Volume: 93, 2016
Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration.The Journal of clinical investigation, , 08-01, Volume: 126, Issue:8, 2016
Neurodegeneration in tauopathies and synucleinopathies.Revue neurologique, , Volume: 172, Issue:11, 2016
[Histopathological and immunohistochemical study of spinal cord tissues in neurodegenerative diseases].Zhonghua bing li xue za zhi = Chinese journal of pathology, , Volume: 44, Issue:8, 2015
Identification of novel autophagic Radix Polygalae fraction by cell membrane chromatography and UHPLC-(Q)TOF-MS for degradation of neurodegenerative disease proteins.Scientific reports, , Nov-24, Volume: 5, 2015
Enduring deficits in memory and neuronal pathology after blast-induced traumatic brain injury.Scientific reports, , Nov-05, Volume: 5, 2015
Histological evidence of chronic traumatic encephalopathy in a large series of neurodegenerative diseases.Acta neuropathologica, , Volume: 130, Issue:6, 2015
Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy.Cell reports, , Oct-27, Volume: 13, Issue:4, 2015
Unveiling transient protein-protein interactions that modulate inhibition of alpha-synuclein aggregation by beta-synuclein, a pre-synaptic protein that co-localizes with alpha-synuclein.Scientific reports, , Oct-19, Volume: 5, 2015
A bacterial metabolite induces glutathione-tractable proteostatic damage, proteasomal disturbances, and PINK1-dependent autophagy in C. elegans.Cell death & disease, , Oct-15, Volume: 6, 2015
Dopamine Transporter Activity Is Modulated by α-Synuclein.The Journal of biological chemistry, , Dec-04, Volume: 290, Issue:49, 2015
Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons.Neurobiology of disease, , Volume: 82, 2015
Differential calcium alterations in animal models of neurodegenerative disease: Reversal by FK506.Neuroscience, , Dec-03, Volume: 310, 2015
Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.Proceedings of the National Academy of Sciences of the United States of America, , Sep-22, Volume: 112, Issue:38, 2015
How many biomarkers to discriminate neurodegenerative dementia?Critical reviews in clinical laboratory sciences, , Volume: 52, Issue:6, 2015
Propagation of prions causing synucleinopathies in cultured cells.Proceedings of the National Academy of Sciences of the United States of America, , Sep-01, Volume: 112, Issue:35, 2015
Validation of a commercially available enzyme-linked immunoabsorbent assay for the quantification of human α-Synuclein in cerebrospinal fluid.Journal of immunological methods, , Volume: 426, 2015
Novel therapeutic approaches in multiple system atrophy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 25, Issue:1, 2015
Neurodegenerative changes in the brainstem and olfactory bulb in people older than 50 years old: a descriptive study.Arquivos de neuro-psiquiatria, , Volume: 73, Issue:7, 2015
Cysteine cathepsins are essential in lysosomal degradation of α-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , Jul-28, Volume: 112, Issue:30, 2015
Validation of a quantitative cerebrospinal fluid alpha-synuclein assay in a European-wide interlaboratory study.Neurobiology of aging, , Volume: 36, Issue:9, 2015
Assessment of the degree of asymmetry of pathological features in neurodegenerative diseases. What is the significance for brain banks?Journal of neural transmission (Vienna, Austria : 1996), , Volume: 122, Issue:10, 2015
Electroacupuncture remediates glial dysfunction and ameliorates neurodegeneration in the astrocytic α-synuclein mutant mouse model.Journal of neuroinflammation, , May-28, Volume: 12, 2015
Nrf2 inducer and cncC overexpression attenuates neurodegeneration due to α-synuclein in Drosophila.Biochemistry and cell biology = Biochimie et biologie cellulaire, , Volume: 93, Issue:4, 2015
The use of cerebrospinal fluid and neuropathologic studies in neuropsychiatry practice and research.The Psychiatric clinics of North America, , Volume: 38, Issue:2, 2015
Curcumin Pyrazole and its derivative (N-(3-Nitrophenylpyrazole) Curcumin inhibit aggregation, disrupt fibrils and modulate toxicity of Wild type and Mutant α-Synuclein.Scientific reports, , May-18, Volume: 5, 2015
Sirtuins and proteolytic systems: implications for pathogenesis of synucleinopathies.Biomolecules, , May-04, Volume: 5, Issue:2, 2015
Role of the unfolded protein response in the pathogenesis of Parkinson's disease.Acta neurobiologiae experimentalis, , Volume: 75, Issue:1, 2015
Characterization of spheroids in hereditary diffuse leukoencephalopathy with axonal spheroids.Journal of the neurological sciences, , May-15, Volume: 352, Issue:1-2, 2015
Post-mortem assessment of the short and long-term effects of the trophic factor neurturin in patients with α-synucleinopathies.Neurobiology of disease, , Volume: 78, 2015
Seeking a mechanism for the toxicity of oligomeric α-synuclein.Biomolecules, , Mar-25, Volume: 5, Issue:2, 2015
Neuropathic alterations of the myenteric plexus neurons following subacute intraperitoneal administration of salsolinol.Folia histochemica et cytobiologica, , Volume: 53, Issue:1, 2015
Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.Experimental & molecular medicine, , Mar-13, Volume: 47, 2015
Role of Different Alpha-Synuclein Strains in Synucleinopathies, Similarities with other Neurodegenerative Diseases.Journal of Parkinson's disease, , Volume: 5, Issue:2, 2015
Effect of α-synuclein on membrane permeability and synaptic transmission: a clue to neurodegeneration?Journal of neurochemistry, , Volume: 132, Issue:6, 2015
Patterns of Tau and α-Synuclein Pathology in the Visual System.Journal of Parkinson's disease, , Volume: 5, Issue:2, 2015
Control tissue in brain banking: the importance of thorough neuropathological assessment.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 122, Issue:7, 2015
Trafficking and degradation pathways in pathogenic conversion of prions and prion-like proteins in neurodegenerative diseases.Virus research, , Sep-02, Volume: 207, 2015
Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization.Angewandte Chemie (International ed. in English), , Feb-16, Volume: 54, Issue:8, 2015
Gaucher-related synucleinopathies: the examination of sporadic neurodegeneration from a rare (disease) angle.Progress in neurobiology, , Volume: 125, 2015
α-Synuclein modifies mutant huntingtin aggregation and neurotoxicity in Drosophila.Human molecular genetics, , Apr-01, Volume: 24, Issue:7, 2015
The synergistic effect between β-amyloid(1-42) and α-synuclein on the synapses dysfunction in hippocampal neurons.Journal of chemical neuroanatomy, , Volume: 63, 2015
Formaldehyde-fixed brain tissue from spontaneously ill α-synuclein transgenic mice induces fatal α-synucleinopathy in transgenic hosts.Acta neuropathologica, , Volume: 129, Issue:1, 2015
Seeding and propagation of lesions in neurodegenerative diseases: a new paradigm.Bulletin de l'Academie nationale de medecine, , Volume: 199, Issue:6, 2015
Protective role of DNJ-27/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases.Antioxidants & redox signaling, , Jan-10, Volume: 20, Issue:2, 2014
Over-expression of an inactive mutant cathepsin D increases endogenous alpha-synuclein and cathepsin B activity in SH-SY5Y cells.Journal of neurochemistry, , Volume: 128, Issue:6, 2014
Preventing α-synuclein aggregation: the role of the small heat-shock molecular chaperone proteins.Biochimica et biophysica acta, , Volume: 1842, Issue:9, 2014
Catecholamine autotoxicity. Implications for pharmacology and therapeutics of Parkinson disease and related disorders.Pharmacology & therapeutics, , Volume: 144, Issue:3, 2014
Interplay between HDAC6 and its interacting partners: essential roles in the aggresome-autophagy pathway and neurodegenerative diseases.DNA and cell biology, , Volume: 33, Issue:9, 2014
Abrogation of α-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats.Proceedings of the National Academy of Sciences of the United States of America, , Jun-24, Volume: 111, Issue:25, 2014
Prions: generation and spread versus neurotoxicity.The Journal of biological chemistry, , Jul-18, Volume: 289, Issue:29, 2014
A bacteriophage capsid protein provides a general amyloid interaction motif (GAIM) that binds and remodels misfolded protein assemblies.Journal of molecular biology, , Jun-26, Volume: 426, Issue:13, 2014
PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology.Brain : a journal of neurology, , Volume: 137, Issue:Pt 5, 2014
ATP6V0C knockdown in neuroblastoma cells alters autophagy-lysosome pathway function and metabolism of proteins that accumulate in neurodegenerative disease.PloS one, , Volume: 9, Issue:4, 2014
RTCB-1 mediates neuroprotection via XBP-1 mRNA splicing in the unfolded protein response pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-26, Volume: 34, Issue:48, 2014
The NOX1/4 inhibitor GKT136901 as selective and direct scavenger of peroxynitrite.Current medicinal chemistry, , Volume: 21, Issue:3, 2014
Protein folding and misfolding in the neurodegenerative disorders: a review.Revue neurologique, , Volume: 170, Issue:3, 2014
Alpha-synuclein and tau: teammates in neurodegeneration?Molecular neurodegeneration, , Oct-29, Volume: 9, 2014
Interactions between calcium and alpha-synuclein in neurodegeneration.Biomolecules, , Aug-14, Volume: 4, Issue:3, 2014
Evidence of native α-synuclein conformers in the human brain.The Journal of biological chemistry, , Mar-14, Volume: 289, Issue:11, 2014
Prion-like mechanisms in the pathogenesis of tauopathies and synucleinopathies.Current neurology and neuroscience reports, , Volume: 14, Issue:11, 2014
Concomitant accumulation of α-synuclein and TDP-43 in a patient with corticobasal degeneration.Journal of neurology, , Volume: 261, Issue:11, 2014
New α- and γ-synuclein immunopathological lesions in human brain.Acta neuropathologica communications, , Sep-11, Volume: 2, 2014
[REM sleep behavior disorder as a prodromal stage of α-synucleinopathies: symptoms, epidemiology, pathophysiology, diagnosis and therapy].Der Nervenarzt, , Volume: 85, Issue:1, 2014
Role of lipid peroxide in the neurodegenerative disorders.Sub-cellular biochemistry, , Volume: 77, 2014
Predictive atomic resolution descriptions of intrinsically disordered hTau40 and α-synuclein in solution from NMR and small angle scattering.Structure (London, England : 1993), , Feb-04, Volume: 22, Issue:2, 2014
Neurodegenerative disease: Yeast cells reveal new target for Parkinson's disease.Nature reviews. Drug discovery, , Volume: 13, Issue:1, 2014
Argyrophilic grain disease as a neurodegenerative substrate in late-onset schizophrenia and delusional disorders.European archives of psychiatry and clinical neuroscience, , Volume: 264, Issue:4, 2014
Molecular imaging insights into neurodegeneration: focus on α-synuclein radiotracers.Journal of nuclear medicine : official publication, Society of Nuclear Medicine, , Volume: 55, Issue:9, 2014
Immunolocalization of human alpha-synuclein in the Thy1-aSyn ("Line 61") transgenic mouse line.Neuroscience, , Sep-26, Volume: 277, 2014
Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins.Disease models & mechanisms, , Volume: 7, Issue:10, 2014
Analysis of dopaminergic neuronal dysfunction in genetic and toxin-induced models of Parkinson's disease in Drosophila.Journal of neurochemistry, , Volume: 131, Issue:3, 2014
Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice.Neurobiology of aging, , Volume: 35, Issue:11, 2014
Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.Science (New York, N.Y.), , Nov-22, Volume: 342, Issue:6161, 2013
Assessing neurodegenerative phenotypes in Drosophila dopaminergic neurons by climbing assays and whole brain immunostaining.Journal of visualized experiments : JoVE, , Apr-24, Issue:74, 2013
Prion-like propagation of protein aggregation and related therapeutic strategies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 10, Issue:3, 2013
Alpha-synuclein expression patterns in the colonic submucosal plexus of the aging Fischer 344 rat: implications for biopsies in aging and neurodegenerative disorders?Neurogastroenterology and motility, , Volume: 25, Issue:9, 2013
The glial marker YKL-40 is decreased in synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:13, 2013
Pressure-temperature folding landscape in proteins involved in neurodegenerative diseases and cancer.Biophysical chemistry, , Dec-15, Volume: 183, 2013
Neurodegenerative disease: can synucleinopathy and tauopathy be identified during life?Nature reviews. Neurology, , Volume: 9, Issue:8, 2013
Neuropathology of partial PGC-1α deficiency recapitulates features of mitochondrial encephalopathies but not of neurodegenerative diseases.Neuro-degenerative diseases, , Volume: 12, Issue:4, 2013
The diagnostic utility of cerebrospinal fluid alpha-synuclein analysis in dementia with Lewy bodies - a systematic review and meta-analysis.Parkinsonism & related disorders, , Volume: 19, Issue:10, 2013
Toxicity of extracellular secreted alpha-synuclein: Its role in nitrosative stress and neurodegeneration.Neurochemistry international, , Volume: 62, Issue:5, 2013
The role of α-synuclein in neurodegenerative diseases: from molecular pathways in disease to therapeutic approaches.Current Alzheimer research, , Volume: 10, Issue:6, 2013
A powerful yeast model to investigate the synergistic interaction of α-synuclein and tau in neurodegeneration.PloS one, , Volume: 8, Issue:2, 2013
Immunotherapy for neurodegenerative diseases: focus on α-synucleinopathies.Pharmacology & therapeutics, , Volume: 138, Issue:3, 2013
α-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity.The Journal of biological chemistry, , Mar-15, Volume: 288, Issue:11, 2013
Curcumin ameliorates the neurodegenerative pathology in A53T α-synuclein cell model of Parkinson's disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 8, Issue:1, 2013
Movement disorders in 2012: Advancing research towards novel therapeutic approaches.Nature reviews. Neurology, , Volume: 9, Issue:2, 2013
Neurodegenerative diseases: quantitative predictions of protein-RNA interactions.RNA (New York, N.Y.), , Volume: 19, Issue:2, 2013
Manganese exposure induces α-synuclein aggregation in the frontal cortex of non-human primates.Toxicology letters, , Mar-13, Volume: 217, Issue:3, 2013
Oxidation and nitration of α-synuclein and their implications in neurodegenerative diseases.Archives of biochemistry and biophysics, , Volume: 533, Issue:1-2, 2013
The many faces of α-synuclein: from structure and toxicity to therapeutic target.Nature reviews. Neuroscience, , Volume: 14, Issue:1, 2013
The neuroendocrine protein 7B2 suppresses the aggregation of neurodegenerative disease-related proteins.The Journal of biological chemistry, , Jan-11, Volume: 288, Issue:2, 2013
Werner coordination chemistry and neurodegeneration.Chemical Society reviews, , Feb-21, Volume: 42, Issue:4, 2013
α-Synuclein elevation in human neurodegenerative diseases: experimental, pathogenetic, and therapeutic implications.Molecular neurobiology, , Volume: 47, Issue:2, 2013
The role of glia in α-synucleinopathies.Molecular neurobiology, , Volume: 47, Issue:2, 2013
Targeting the chameleon: a focused look at α-synuclein and its roles in neurodegeneration.Molecular neurobiology, , Volume: 47, Issue:2, 2013
α-Synuclein posttranslational modification and alternative splicing as a trigger for neurodegeneration.Molecular neurobiology, , Volume: 47, Issue:2, 2013
Molecular chaperones, α-synuclein, and neurodegeneration.Molecular neurobiology, , Volume: 47, Issue:2, 2013
The potential prognostic role of cardiovascular autonomic failure in α-synucleinopathies.European journal of neurology, , Volume: 20, Issue:2, 2013
Neurodegeneration-associated protein fragments as short-lived substrates of the N-end rule pathway.Molecular cell, , Apr-25, Volume: 50, Issue:2, 2013
The Lewy body in Parkinson's disease and related neurodegenerative disorders.Molecular neurobiology, , Volume: 47, Issue:2, 2013
Treatment implications of the altered cytokine-insulin axis in neurodegenerative disease.Biochemical pharmacology, , Oct-01, Volume: 86, Issue:7, 2013
Clinical markers of early nigrostriatal neurodegeneration in idiopathic rapid eye movement sleep behavior disorder.Sleep medicine, , Volume: 14, Issue:11, 2013
[Neurotoxicity of pesticides: its relationship with neurodegenerative diseases].Medecine sciences : M/S, , Volume: 29, Issue:3, 2013
Alpha-synuclein post-translational modifications as potential biomarkers for Parkinson disease and other synucleinopathies.Molecular & cellular proteomics : MCP, , Volume: 12, Issue:12, 2013
Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathies.Acta neuropathologica communications, , Dec-05, Volume: 1, 2013
The role of crowded physiological environments in prion and prion-like protein aggregation.International journal of molecular sciences, , Oct-25, Volume: 14, Issue:11, 2013
[Multiple functions of Gh/transglutaminase 2].Nihon yakurigaku zasshi. Folia pharmacologica Japonica, , Volume: 141, Issue:4, 2013
Self-propagation of pathogenic protein aggregates in neurodegenerative diseases.Nature, , Sep-05, Volume: 501, Issue:7465, 2013
Propagating sticky matters: an update on "prion-like" templated misfolding in neurodegenerative disorders.Brain pathology (Zurich, Switzerland), , Volume: 23, Issue:3, 2013
Synaptic dysfunction in synucleinopathies.CNS & neurological disorders drug targets, , Volume: 12, Issue:8, 2013
Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells.International journal of molecular sciences, , Nov-15, Volume: 14, Issue:11, 2013
Single-chain fragment variable passive immunotherapies for neurodegenerative diseases.International journal of molecular sciences, , Sep-17, Volume: 14, Issue:9, 2013
The function of α-synuclein.Neuron, , Sep-18, Volume: 79, Issue:6, 2013
[Neurodegeneration and epigenetics].Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, , Volume: 32, Issue:5-6, 2012
Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias.Brain : a journal of neurology, , Volume: 135, Issue:Pt 12, 2012
An intrinsically disordered region of the acetyltransferase p300 with similarity to prion-like domains plays a role in aggregation.PloS one, , Volume: 7, Issue:11, 2012
Endosomal sorting related protein CHMP2B is localized in Lewy bodies and glial cytoplasmic inclusions in α-synucleinopathy.Neuroscience letters, , Oct-03, Volume: 527, Issue:1, 2012
Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders.Archives of neurology, , Volume: 69, Issue:11, 2012
Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy.Molecular neurodegeneration, , Aug-14, Volume: 7, 2012
Novel one-step immunoassays to quantify α-synuclein: applications for biomarker development and high-throughput screening.The Journal of biological chemistry, , Sep-28, Volume: 287, Issue:40, 2012
Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with α-synuclein at the single molecule level.Molecular neurodegeneration, , Jul-23, Volume: 7, 2012
Overexpression of parkin ameliorates dopaminergic neurodegeneration induced by 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.PloS one, , Volume: 7, Issue:6, 2012
Protein degradation pathways in Parkinson's disease: curse or blessing.Acta neuropathologica, , Volume: 124, Issue:2, 2012
[The role of proteins in neurodegenerative disease].Postepy higieny i medycyny doswiadczalnej (Online), , Apr-16, Volume: 66, 2012
Common features at the start of the neurodegeneration cascade.PLoS biology, , Volume: 10, Issue:5, 2012
[Role of septin cytoskeleton in dopaminergic neurotransmission and neurodegeneration].Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, , Volume: 32, Issue:1, 2012
Prion-like spread of protein aggregates in neurodegeneration.The Journal of experimental medicine, , May-07, Volume: 209, Issue:5, 2012
Detection of α-synuclein aggregates by fluorescence microscopy.Rejuvenation research, , Volume: 15, Issue:2, 2012
Systemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human α-synuclein under oligodendrocyte promoter: implications for multiple system atrophy.Acta neuropathologica, , Volume: 124, Issue:1, 2012
Autophagic adapter protein NBR1 is localized in Lewy bodies and glial cytoplasmic inclusions and is involved in aggregate formation in α-synucleinopathy.Acta neuropathologica, , Volume: 124, Issue:2, 2012
Protein quality control in neurodegenerative disease.Progress in molecular biology and translational science, , Volume: 107, 2012
Membrane pores in the pathogenesis of neurodegenerative disease.Progress in molecular biology and translational science, , Volume: 107, 2012
Regional deficiencies in chaperone-mediated autophagy underlie α-synuclein aggregation and neurodegeneration.Neurobiology of disease, , Volume: 46, Issue:3, 2012
Phosphorylated α-synuclein as a potential biomarker for Parkinson's disease and related disorders.Expert review of molecular diagnostics, , Volume: 12, Issue:2, 2012
Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.Human molecular genetics, , Jun-01, Volume: 21, Issue:11, 2012
Long-term polarization of microglia upon α-synuclein overexpression in nonhuman primates.Neuroscience, , Apr-19, Volume: 208, 2012
Emerging neurotoxic mechanisms in environmental factors-induced neurodegeneration.Neurotoxicology, , Volume: 33, Issue:4, 2012
Head injury, α-synuclein Rep1, and Parkinson's disease.Annals of neurology, , Volume: 71, Issue:1, 2012
Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons.Neurobiology of disease, , Volume: 45, Issue:3, 2012
Interaction between pathogenic proteins in neurodegenerative disorders.Journal of cellular and molecular medicine, , Volume: 16, Issue:6, 2012
Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons.Acta neuropathologica, , Volume: 123, Issue:5, 2012
α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases.Journal of neurochemistry, , Volume: 120, Issue:3, 2012
L-NAME cotreatment did prevent neither mitochondrial impairment nor behavioral abnormalities in adult Wistar rats treated with vitamin A supplementation.Fundamental & clinical pharmacology, , Volume: 26, Issue:4, 2012
[Alpha-synuclein].Nihon rinsho. Japanese journal of clinical medicine, , Volume: 69 Suppl 8, 2011
[Seed, aggregation and propagation of abnormal proteins could explain neurodegeneration?].Rinsho shinkeigaku = Clinical neurology, , Volume: 51, Issue:11, 2011
Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons.Molecular neurodegeneration, , Dec-13, Volume: 6, 2011
[Role of genetics in the etiology of synucleinopathies].Revista espanola de geriatria y gerontologia, , Volume: 46 Suppl 1, 2011
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Interaction between α-synuclein and other proteins in neurodegenerative disorders.TheScientificWorldJournal, , Volume: 11, 2011
Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-16, Volume: 31, Issue:46, 2011
CSF levels of oligomeric alpha-synuclein and beta-amyloid as biomarkers for neurodegenerative disease.Integrative biology : quantitative biosciences from nano to macro, , Volume: 3, Issue:12, 2011
α-Synuclein stimulates a dopamine transporter-dependent chloride current and modulates the activity of the transporter.The Journal of biological chemistry, , Dec-23, Volume: 286, Issue:51, 2011
Parallel manifestations of neuropathologies in the enteric and central nervous systems.Neurogastroenterology and motility, , Volume: 23, Issue:12, 2011
Air pollution & the brain: Subchronic diesel exhaust exposure causes neuroinflammation and elevates early markers of neurodegenerative disease.Journal of neuroinflammation, , Aug-24, Volume: 8, 2011
E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment.The Journal of biological chemistry, , Oct-07, Volume: 286, Issue:40, 2011
Inflammation in the early stages of neurodegenerative pathology.Journal of neuroimmunology, , Sep-15, Volume: 238, Issue:1-2, 2011
Toll-like receptor 4 promotes α-synuclein clearance and survival of nigral dopaminergic neurons.The American journal of pathology, , Volume: 179, Issue:2, 2011
Multiprotein deposits in neurodegenerative disorders: our experience in the tissue brain bank of Navarra.Anatomical record (Hoboken, N.J. : 2007), , Volume: 294, Issue:7, 2011
Stress, allostatic load, catecholamines, and other neurotransmitters in neurodegenerative diseases.Endocrine regulations, , Volume: 45, Issue:2, 2011
Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts.Acta neuropathologica, , Volume: 121, Issue:6, 2011
Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse model.The Journal of neuroscience : the official journal of the Society for Neuroscience, , May-11, Volume: 31, Issue:19, 2011
Parkinson disease: PD biomarkers-use of α-synuclein reaches new levels.Nature reviews. Neurology, , May-10, Volume: 7, Issue:6, 2011
SUMO and its role in human diseases.International review of cell and molecular biology, , Volume: 288, 2011
Cerebrospinal fluid Tau/α-synuclein ratio in Parkinson's disease and degenerative dementias.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:8, 2011
Structures of segments of α-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation.Protein science : a publication of the Protein Society, , Volume: 20, Issue:6, 2011
Targeting oligomers in neurodegenerative disorders: lessons from α-synuclein, tau, and amyloid-β peptide.Journal of Alzheimer's disease : JAD, , Volume: 24 Suppl 2, 2011
Glycosaminoglycans, protein aggregation and neurodegeneration.Current protein & peptide science, , Volume: 12, Issue:3, 2011
α-Synuclein in Parkinson disease and other neurodegenerative disorders.Clinical chemistry and laboratory medicine, , Volume: 49, Issue:3, 2011
Biochemical and morphological consequences of human α-synuclein expression in a mouse α-synuclein null background.The European journal of neuroscience, , Volume: 33, Issue:4, 2011
Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease.Environmental health perspectives, , Volume: 119, Issue:6, 2011
Interaction of prolyl oligopeptidase with α-synuclein.CNS & neurological disorders drug targets, , Volume: 10, Issue:3, 2011
Chaperoning the SNAREs: a role in preventing neurodegeneration?Nature cell biology, , Volume: 13, Issue:1, 2011
The role of α-synuclein in neurotransmission and synaptic plasticity.Journal of chemical neuroanatomy, , Volume: 42, Issue:4, 2011
Insights into the thermodynamics of copper association with amyloid-β, α-synuclein and prion proteins.Metallomics : integrated biometal science, , Volume: 3, Issue:3, 2011
Inducible dopaminergic glutathione depletion in an α-synuclein transgenic mouse model results in age-related olfactory dysfunction.Neuroscience, , Jan-13, Volume: 172, 2011
Lipid classes and fatty acid patterns are altered in the brain of γ-synuclein null mutant mice.Lipids, , Volume: 46, Issue:2, 2011
Aberrant protein structure and diseases of the brain.Irish journal of medical science, , Volume: 180, Issue:1, 2011
Nanoprobing of α-synuclein misfolding and aggregation with atomic force microscopy.Nanomedicine : nanotechnology, biology, and medicine, , Volume: 7, Issue:2, 2011
Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity.PloS one, , Nov-16, Volume: 5, Issue:11, 2010
Antibody therapy in neurodegenerative disease.Reviews in the neurosciences, , Volume: 21, Issue:4, 2010
Preparation and characterization of neurotoxic tau oligomers.Biochemistry, , Nov-30, Volume: 49, Issue:47, 2010
Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases.The Journal of biological chemistry, , Nov-05, Volume: 285, Issue:45, 2010
Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity.Cell, , Aug-20, Volume: 142, Issue:4, 2010
Multiple non-cell autonomous actions of alpha-synuclein in neurodegenerative diseases: Is there a direct link?Cell cycle (Georgetown, Tex.), , Jul-15, Volume: 9, Issue:14, 2010
[GSK-3beta: a central kinase for neurodegenerative diseases?].Medecine sciences : M/S, , Volume: 26, Issue:5, 2010
Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases.Cell death and differentiation, , Volume: 17, Issue:11, 2010
Early aggregation steps in alpha-synuclein as measured by FCS and FRET: evidence for a contagious conformational change.Biophysical journal, , Apr-07, Volume: 98, Issue:7, 2010
ASIP Outstanding Investigator Award Lecture. New approaches to the pathology and genetics of neurodegeneration.The American journal of pathology, , Volume: 176, Issue:5, 2010
Oligomeric alpha-synuclein and its role in neuronal death.IUBMB life, , Volume: 62, Issue:5, 2010
Distinct region-specific alpha-synuclein oligomers in A53T transgenic mice: implications for neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-03, Volume: 30, Issue:9, 2010
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-03, Volume: 30, Issue:9, 2010
Protein coding of neurodegenerative dementias: the neuropathological basis of biomarker diagnostics.Acta neuropathologica, , Volume: 119, Issue:4, 2010
Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies.The Journal of biological chemistry, , Mar-19, Volume: 285, Issue:12, 2010
Prion-like mechanisms in neurodegenerative diseases.Nature reviews. Neuroscience, , Volume: 11, Issue:3, 2010
Residue Glu83 plays a major role in negatively regulating alpha-synuclein amyloid formation.Biochemical and biophysical research communications, , Jan-15, Volume: 391, Issue:3, 2010
The effect of prolonged fixation time on immunohistochemical staining of common neurodegenerative disease markers.Journal of neuropathology and experimental neurology, , Volume: 69, Issue:1, 2010
Trichloroethylene induces dopaminergic neurodegeneration in Fisher 344 rats.Journal of neurochemistry, , Volume: 112, Issue:3, 2010
Converse modulation of toxic alpha-synuclein oligomers in living cells by N'-benzylidene-benzohydrazide derivates and ferric iron.Biochemical and biophysical research communications, , Jan-01, Volume: 391, Issue:1, 2010
Recurrent systemic infections with Streptococcus pneumoniae do not aggravate the course of experimental neurodegenerative diseases.Journal of neuroscience research, , Volume: 88, Issue:5, 2010
Finding order within disorder: elucidating the structure of proteins associated with neurodegenerative disease.Future medicinal chemistry, , Volume: 1, Issue:3, 2009
Neurodegeneration. Could they all be prion diseases?Science (New York, N.Y.), , Dec-04, Volume: 326, Issue:5958, 2009
Neuropathology of non-Alzheimer degenerative disorders.International journal of clinical and experimental pathology, , Aug-25, Volume: 3, Issue:1, 2009
Investigating bacterial sources of toxicity as an environmental contributor to dopaminergic neurodegeneration.PloS one, , Oct-06, Volume: 4, Issue:10, 2009
Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration.Proceedings of the National Academy of Sciences of the United States of America, , Aug-18, Volume: 106, Issue:33, 2009
On the mechanism of nonspecific inhibitors of protein aggregation: dissecting the interactions of alpha-synuclein with Congo red and lacmoid.Biochemistry, , Sep-08, Volume: 48, Issue:35, 2009
Neurobiology of cognitive disorders.Current opinion in psychiatry, , Volume: 22, Issue:6, 2009
The paradoxical cell biology of alpha-Synucle.Results and problems in cell differentiation, , Volume: 48, 2009
Trends in the molecular pathogenesis and clinical therapeutics of common neurodegenerative disorders.International journal of molecular sciences, , Jun-03, Volume: 10, Issue:6, 2009
Enhanced alpha-synuclein expression in human neurodegenerative diseases: pathogenetic and therapeutic implications.Current protein & peptide science, , Volume: 10, Issue:5, 2009
Leucine-rich repeat kinase 2 expression leads to aggresome formation that is not associated with alpha-synuclein inclusions.Journal of neuropathology and experimental neurology, , Volume: 68, Issue:7, 2009
Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration.PloS one, , Jun-03, Volume: 4, Issue:6, 2009
Intrinsic disorder in proteins associated with neurodegenerative diseases.Frontiers in bioscience (Landmark edition), , 06-01, Volume: 14, Issue:14, 2009
Nucleic acid induced protein aggregation and its role in biology and pathology.Frontiers in bioscience (Landmark edition), , 06-01, Volume: 14, Issue:13, 2009
Recent developments in multiple system atrophy.Journal of neurology, , Volume: 256, Issue:11, 2009
On the mechanism of internalization of alpha-synuclein into microglia: roles of ganglioside GM1 and lipid raft.Journal of neurochemistry, , Volume: 110, Issue:1, 2009
Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction.Acta neuropathologica, , Volume: 117, Issue:6, 2009
[Pathology of basal ganglia in neurodegenerative diseases].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 61, Issue:4, 2009
Alpha-Synuclein contributes to GSK-3beta-catalyzed Tau phosphorylation in Parkinson's disease models.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 23, Issue:9, 2009
Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies.The American journal of pathology, , Volume: 174, Issue:5, 2009
Nigral degeneration with inclusion body formation and behavioral changes in rats after proteasomal inhibition.Stereotactic and functional neurosurgery, , Volume: 87, Issue:2, 2009
Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases.Biochimica et biophysica acta, , Volume: 1790, Issue:7, 2009
Increased frequency of alpha-synuclein in the substantia nigra in human immunodeficiency virus infection.Journal of neurovirology, , Volume: 15, Issue:2, 2009
Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss?Neuroscience letters, , Feb-06, Volume: 450, Issue:3, 2009
Common key-signals in learning and neurodegeneration: focus on excito-amino acids, beta-amyloid peptides and alpha-synuclein.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 116, Issue:8, 2009
alpha-Synuclein protofibrils inhibit 26 S proteasome-mediated protein degradation: understanding the cytotoxicity of protein protofibrils in neurodegenerative disease pathogenesis.The Journal of biological chemistry, , Jul-18, Volume: 283, Issue:29, 2008
Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinson's disease.Glia, , Aug-15, Volume: 56, Issue:11, 2008
What determines the molecular composition of abnormal protein aggregates in neurodegenerative disease?Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 28, Issue:4, 2008
Characterization of antibodies that selectively detect alpha-synuclein in pathological inclusions.Acta neuropathologica, , Volume: 116, Issue:1, 2008
The role of alpha-synuclein in neurodegenerative diseases: a potential target for new treatment strategies?Neuro-degenerative diseases, , Volume: 5, Issue:3-4, 2008
Aggregopathy in neurodegenerative diseases: mechanisms and therapeutic implication.Neuro-degenerative diseases, , Volume: 5, Issue:6, 2008
A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides.Nature neuroscience, , Volume: 11, Issue:3, 2008
Fitting neurological protein aggregation kinetic data via a 2-step, minimal/"Ockham's razor" model: the Finke-Watzky mechanism of nucleation followed by autocatalytic surface growth.Biochemistry, , Feb-26, Volume: 47, Issue:8, 2008
The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease.Proceedings of the National Academy of Sciences of the United States of America, , Jan-15, Volume: 105, Issue:2, 2008
Beer and bread to brains and beyond: can yeast cells teach us about neurodegenerative disease?Neuro-Signals, , Volume: 16, Issue:1, 2008
How is protein aggregation in amyloidogenic diseases modulated by biological membranes?European biophysics journal : EBJ, , Volume: 37, Issue:3, 2008
Autonomic dysfunction in RBD--what can it teach us about disease progression?Sleep medicine, , Volume: 9, Issue:5, 2008
alpha-Synucleinopathy models and human neuropathology: similarities and differences.Acta neuropathologica, , Volume: 115, Issue:1, 2008
[Recent progress and future direction of neurodegenerative disease research].Rinsho shinkeigaku = Clinical neurology, , Volume: 48, Issue:11, 2008
Metal catalyzed oxidation of alpha-synuclein--a role for oligomerization in pathology?Current Alzheimer research, , Volume: 5, Issue:6, 2008
Modulation of alpha-synuclein expression in transgenic animals for modelling synucleinopathies--is the juice worth the squeeze?Neurotoxicity research, , Volume: 14, Issue:4, 2008
Is malfunction of the ubiquitin proteasome system the primary cause of alpha-synucleinopathies and other chronic human neurodegenerative disease?Biochimica et biophysica acta, , Volume: 1782, Issue:12, 2008
Alpha-synuclein misfolding and neurodegenerative diseases.Current protein & peptide science, , Volume: 9, Issue:5, 2008
Enduring involvement of tau, beta-amyloid, alpha-synuclein, ubiquitin and TDP-43 pathology in the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam (ALS/PDC).Acta neuropathologica, , Volume: 116, Issue:6, 2008
[Molecular neuropathology of Non-Alzheimer dementia].Der Pathologe, , Volume: 29, Issue:6, 2008
Insights into the effects of alpha-synuclein expression and proteasome inhibition on glutathione metabolism through a dynamic in silico model of Parkinson's disease: validation by cell culture data.Free radical biology & medicine, , Nov-01, Volume: 45, Issue:9, 2008
Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease.The Journal of clinical investigation, , Volume: 118, Issue:9, 2008
Neurofibrillary tau pathology modulated by genetic variation of alpha-synuclein.Annals of neurology, , Volume: 64, Issue:3, 2008
Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jul-23, Volume: 28, Issue:30, 2008
Biologic models of neurodegenerative disorders.Handbook of clinical neurology, , Volume: 89, 2008
A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in alpha-synuclein transgenic C. elegans.Human molecular genetics, , Oct-01, Volume: 17, Issue:19, 2008
Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders.Autoimmunity reviews, , Volume: 7, Issue:6, 2008
Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease.Neuroscience letters, , Jul-11, Volume: 439, Issue:2, 2008
Is alpha-synuclein pathology a target for treatment of neurodegenerative disorders?Current Alzheimer research, , Volume: 4, Issue:5, 2007
Brain tissue microarrays in neurodegenerative diseases: validation of methodology and immunohistochemical study of growth-associated protein-43 and calretinin.Pathology international, , Volume: 57, Issue:12, 2007
Phosphorylated Smad 2/3 colocalizes with phospho-tau inclusions in Pick disease, progressive supranuclear palsy, and corticobasal degeneration but not with alpha-synuclein inclusions in multiple system atrophy or dementia with Lewy bodies.Journal of neuropathology and experimental neurology, , Volume: 66, Issue:11, 2007
Protein aggregation mechanisms in synucleinopathies: commonalities and differences.Journal of neuropathology and experimental neurology, , Volume: 66, Issue:11, 2007
Lipid rafts, protein scaffolds, and neurologic disease.Neurology, , Oct-16, Volume: 69, Issue:16, 2007
Is alpha-synuclein pathology a target for treatment of neurodegenerative disorders?Current Alzheimer research, , Volume: 4, Issue:4, 2007
Functional protein kinase arrays reveal inhibition of p-21-activated kinase 4 by alpha-synuclein oligomers.Journal of neurochemistry, , Volume: 103, Issue:6, 2007
[Study on pathophysiology of autophagy].Seikagaku. The Journal of Japanese Biochemical Society, , Volume: 79, Issue:8, 2007
Transgenic animal models of neurodegenerative diseases and their application to treatment development.Advanced drug delivery reviews, , Sep-30, Volume: 59, Issue:11, 2007
Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies.FEBS letters, , Oct-02, Volume: 581, Issue:24, 2007
Correlation of amyloid fibril beta-structure with the unfolded state of alpha-synuclein.Chembiochem : a European journal of chemical biology, , Sep-24, Volume: 8, Issue:14, 2007
Medicine. The yin-yang of sirtuins.Science (New York, N.Y.), , Jul-27, Volume: 317, Issue:5837, 2007
Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation.Journal of neurochemistry, , Volume: 103, Issue:1, 2007
Classical Parkinson disease versus Parkinson complex--reflections against staging and in favour of heterogeneity.European journal of neurology, , Volume: 14, Issue:7, 2007
Determination of alpha-synuclein concentration in human plasma using ELISA.Scandinavian journal of clinical and laboratory investigation, , Volume: 67, Issue:4, 2007
Alpha-synuclein pathology in the olfactory pathways of dementia patients.Journal of anatomy, , Volume: 211, Issue:1, 2007
Immunohistochemical localization of NUB1, a synphilin-1-binding protein, in neurodegenerative disorders.Acta neuropathologica, , Volume: 114, Issue:4, 2007
DNA induces folding in alpha-synuclein: understanding the mechanism using chaperone property of osmolytes.Archives of biochemistry and biophysics, , Aug-01, Volume: 464, Issue:1, 2007
Expanding insights on the involvement of endoplasmic reticulum stress in Parkinson's disease.Antioxidants & redox signaling, , Volume: 9, Issue:5, 2007
Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.Journal of neurochemistry, , Volume: 101, Issue:6, 2007
alpha-Synuclein and its disease-related mutants interact differentially with the microtubule protein tau and associate with the actin cytoskeleton.Neurobiology of disease, , Volume: 26, Issue:3, 2007
Predominant neuritic pathology induced by viral overexpression of alpha-synuclein in cell culture.Cellular and molecular neurobiology, , Volume: 27, Issue:4, 2007
Adult-onset neurodegeneration with brain iron accumulation and cortical alpha-synuclein and tau pathology: a distinct clinicopathological entity.Archives of neurology, , Volume: 64, Issue:2, 2007
Metals ions and neurodegeneration.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, , Volume: 20, Issue:3-4, 2007
[Animal models of neurodegenerative diseases].Medecine sciences : M/S, , Volume: 23, Issue:2, 2007
PINK1, a gene product of PARK6, accumulates in alpha-synucleinopathy brains.Journal of neurology, neurosurgery, and psychiatry, , Volume: 78, Issue:6, 2007
The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases.Acta neuropathologica, , Volume: 113, Issue:2, 2007
Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice.Neurobiology of aging, , Volume: 28, Issue:9, 2007
Rescuing defective vesicular trafficking protects against alpha-synuclein toxicity in cellular and animal models of Parkinson's disease.ACS chemical biology, , Aug-22, Volume: 1, Issue:7, 2006
REM sleep behavior disorder: a possible early marker for synucleinopathies.Neurology, , Dec-12, Volume: 67, Issue:11, 2006
Identification of G-protein coupled receptor kinase 2 in paired helical filaments and neurofibrillary tangles.Journal of neuropathology and experimental neurology, , Volume: 65, Issue:12, 2006
[Nosology of dementias: the neuropathologist's point of view].Revue neurologique, , Volume: 162, Issue:10, 2006
Mechanisms and models of alpha-synuclein-related neurodegeneration.Current neurology and neuroscience reports, , Volume: 6, Issue:5, 2006
Glial degeneration and reactive gliosis in alpha-synucleinopathies: the emerging concept of primary gliodegeneration.Acta neuropathologica, , Volume: 112, Issue:5, 2006
New directions for neurodegenerative disease therapy: using chemical compounds to boost the formation of mutant protein inclusions.Cell cycle (Georgetown, Tex.), , Volume: 5, Issue:14, 2006
[Neurodegenerative conformational disease and its molecular bases].Sheng li ke xue jin zhan [Progress in physiology], , Volume: 37, Issue:2, 2006
The genetics of neurodegenerative diseases.Journal of neurochemistry, , Volume: 97, Issue:6, 2006
Archaeal proteasomes effectively degrade aggregation-prone proteins and reduce cellular toxicities in mammalian cells.The Journal of biological chemistry, , Aug-18, Volume: 281, Issue:33, 2006
Emerging evidence for the neuroprotective role of alpha-synuclein.Experimental neurology, , Volume: 200, Issue:1, 2006
Cytoskeleton/endoplasmic reticulum collapse induced by prostaglandin J2 parallels centrosomal deposition of ubiquitinated protein aggregates.The Journal of biological chemistry, , Aug-11, Volume: 281, Issue:32, 2006
Atypical protein kinase C in neurodegenerative disease II: PKCiota/lambda in tauopathies and alpha-synucleinopathies.Journal of neuropathology and experimental neurology, , Volume: 65, Issue:4, 2006
Hero versus antihero: the multiple roles of alpha-synuclein in neurodegeneration.Experimental neurology, , Volume: 199, Issue:2, 2006
Human brain tissue microarrays as a platform to investigate diseases of the nervous system.Brain research, , May-17, Volume: 1089, Issue:1, 2006
Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies.The American journal of pathology, , Volume: 168, Issue:3, 2006
Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein.The Journal of biological chemistry, , Apr-14, Volume: 281, Issue:15, 2006
Tau-predominant-associated pathology in a sporadic late-onset Hallervorden-Spatz syndrome.Movement disorders : official journal of the Movement Disorder Society, , Volume: 21, Issue:1, 2006
Studies of the aggregation of an amyloidogenic alpha-synuclein peptide fragment.Biochemical Society transactions, , Volume: 33, Issue:Pt 5, 2005
Alpha-synuclein aggregation in neurodegenerative diseases and its inhibition as a potential therapeutic strategy.Biochemical Society transactions, , Volume: 33, Issue:Pt 5, 2005
Metal ions and oxidative protein modification in neurological disease.Annali dell'Istituto superiore di sanita, , Volume: 41, Issue:2, 2005
The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy.British journal of pharmacology, , Volume: 146, Issue:8, 2005
Prediction of "hot spots" of aggregation in disease-linked polypeptides.BMC structural biology, , Sep-30, Volume: 5, 2005
Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and drug-induced rotational asymmetry in hemi-parkinsonian rats.Journal of neurochemistry, , Volume: 95, Issue:4, 2005
Agrin binds alpha-synuclein and modulates alpha-synuclein fibrillation.Glycobiology, , Volume: 15, Issue:12, 2005
The role of alpha-synuclein and tau in neurodegenerative movement disorders.Current opinion in neurology, , Volume: 18, Issue:4, 2005
Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology.Acta neuropathologica, , Volume: 110, Issue:2, 2005
Neuronal intranuclear inclusion disease without polyglutamine inclusions in a child.Journal of neuropathology and experimental neurology, , Volume: 64, Issue:6, 2005
Prediction of "aggregation-prone" and "aggregation-susceptible" regions in proteins associated with neurodegenerative diseases.Journal of molecular biology, , Jul-08, Volume: 350, Issue:2, 2005
Pathogenic effects of alpha-synuclein aggregation.Brain research. Molecular brain research, , Mar-24, Volume: 134, Issue:1, 2005
Alpha-synuclein aggregation and its relation to neurodegenerative diseases.Annals of neurology, , Volume: 57, Issue:4, 2005
The role of alpha-synuclein in neurodegenerative diseases.Pharmacology & therapeutics, , Volume: 105, Issue:3, 2005
Annular alpha-synuclein oligomers are potentially toxic agents in alpha-synucleinopathy. Hypothesis.Neurotoxicity research, , Volume: 7, Issue:1-2, 2005
p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies.The Journal of biological chemistry, , Feb-18, Volume: 280, Issue:7, 2005
Lewy bodies in the amygdala: increase of alpha-synuclein aggregates in neurodegenerative diseases with tau-based inclusions.Archives of neurology, , Volume: 61, Issue:12, 2004
Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Oct-20, Volume: 24, Issue:42, 2004
Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies.Neurobiology of disease, , Volume: 17, Issue:2, 2004
Alpha-synuclein and transgenic mouse models.Neurobiology of disease, , Volume: 17, Issue:2, 2004
[Analysis of alpha-synuclein and its significance].Nihon rinsho. Japanese journal of clinical medicine, , Volume: 62, Issue:9, 2004
Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro.Biochemical and biophysical research communications, , Aug-27, Volume: 321, Issue:3, 2004
Beta-Synuclein-derived peptides with neuroprotective activity: an alternative treatment of neurodegenerative disorders?Journal of molecular neuroscience : MN, , Volume: 24, Issue:1, 2004
Neurodegenerative diseases caused by protein aggregation: a phenomenon at the borderline between molecular evolution and ageing.Pharmacological research, , Volume: 50, Issue:4, 2004
Does cellular iron dysregulation play a causative role in Parkinson's disease?Ageing research reviews, , Volume: 3, Issue:3, 2004
Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling.Proceedings of the National Academy of Sciences of the United States of America, , Jun-01, Volume: 101, Issue:22, 2004
Following the leader: fibrillization of alpha-synuclein and tau.Experimental neurology, , Volume: 187, Issue:2, 2004
Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons.The Journal of cell biology, , May-10, Volume: 165, Issue:3, 2004
Alpha-synuclein: normal function and role in neurodegenerative diseases.Current topics in developmental biology, , Volume: 60, 2004
More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases.Trends in neurosciences, , Volume: 27, Issue:3, 2004
Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-25, Volume: 24, Issue:8, 2004
Proteasomal inhibition by alpha-synuclein filaments and oligomers.The Journal of biological chemistry, , Mar-26, Volume: 279, Issue:13, 2004
[Neuropathology of tauopathies and synucleinopathies, and neuroanatomy of sleep disorders: meeting the challenge].Revue neurologique, , Volume: 159, Issue:11 Suppl, 2003
Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation.Molecular and cellular neurosciences, , Volume: 24, Issue:2, 2003
Mutations in the lipid-binding domain of alpha-synuclein confer overlapping, yet distinct, functional properties in the regulation of dopamine transporter activity.Molecular and cellular neurosciences, , Volume: 24, Issue:1, 2003
Interactions of amyloidogenic proteins.Neuromolecular medicine, , Volume: 4, Issue:1-2, 2003
Challenges and complexities of alpha-synuclein toxicity: new postulates in unfolding the mystery associated with Parkinson's disease.Archives of biochemistry and biophysics, , Oct-15, Volume: 418, Issue:2, 2003
Alpha-synuclein oligomerization: a role for lipids?Trends in neurosciences, , Volume: 26, Issue:10, 2003
Altered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathies.The Journal of biological chemistry, , Dec-12, Volume: 278, Issue:50, 2003
Tau pathology in the olfactory bulb correlates with Braak stage, Lewy body pathology and apolipoprotein epsilon4.Neuropathology and applied neurobiology, , Volume: 29, Issue:5, 2003
Clinical overview of the synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 18 Suppl 6, 2003
Neuropathological spectrum of synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 18 Suppl 6, 2003
Alpha-synuclein: between synaptic function and dysfunction.Histology and histopathology, , Volume: 18, Issue:4, 2003
A protein-chameleon: conformational plasticity of alpha-synuclein, a disordered protein involved in neurodegenerative disorders.Journal of biomolecular structure & dynamics, , Volume: 21, Issue:2, 2003
A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114.Journal of neurochemistry, , Volume: 86, Issue:6, 2003
Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of alpha-synuclein.Brain pathology (Zurich, Switzerland), , Volume: 13, Issue:3, 2003
Toward a molecular neuropsychiatry of neurodegenerative diseases.Annals of neurology, , Volume: 54, Issue:2, 2003
Cell cycle aberrations by alpha-synuclein over-expression and cyclin B immunoreactivity in Lewy bodies.Neurobiology of aging, , Volume: 24, Issue:5, 2003
Oxidative modifications of alpha-synuclein.Annals of the New York Academy of Sciences, , Volume: 991, 2003
Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease.Neuropharmacology, , Volume: 45, Issue:1, 2003
Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein.Journal of neurochemistry, , Volume: 86, Issue:1, 2003
Alpha-synuclein: its biological function and role in neurodegenerative diseases.Journal of molecular neuroscience : MN, , Volume: 20, Issue:2, 2003
Familial idiopathic brain calcification--a new and familial alpha-synucleinopathy?European neurology, , Volume: 49, Issue:4, 2003
Alpha-synuclein aggregation and neurodegenerative diseases.Journal of Alzheimer's disease : JAD, , Volume: 5, Issue:2, 2003
Alpha-synuclein overexpression protects against paraquat-induced neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Apr-15, Volume: 23, Issue:8, 2003
Initiation and synergistic fibrillization of tau and alpha-synuclein.Science (New York, N.Y.), , Apr-25, Volume: 300, Issue:5619, 2003
Association of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathies.The Journal of biological chemistry, , Jun-27, Volume: 278, Issue:26, 2003
Ubiquitinated inclusions and neuronal cell death.Histology and histopathology, , Volume: 18, Issue:2, 2003
Alpha-synuclein pathology affecting Bergmann glia of the cerebellum in patients with alpha-synucleinopathies.Acta neuropathologica, , Volume: 105, Issue:4, 2003
Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , Mar-04, Volume: 100, Issue:5, 2003
Nucleus-specific alteration of raphe neurons in human neurodegenerative disorders.Neuroreport, , Jan-20, Volume: 14, Issue:1, 2003
Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila.Neuroscience letters, , Jan-23, Volume: 336, Issue:3, 2003
Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.Experimental neurology, , Volume: 179, Issue:1, 2003
Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.Neuron, , May-16, Volume: 34, Issue:4, 2002
The cell biology of alpha-synuclein: a sticky problem?Neuromolecular medicine, , Volume: 1, Issue:2, 2002
Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Apr-01, Volume: 22, Issue:7, 2002
Ultrastructure of alpha-synuclein-positive aggregations in U373 astrocytoma and rat primary glial cells.Neuroscience letters, , Apr-19, Volume: 323, Issue:1, 2002
Immunocytochemical localization of synphilin-1, an alpha-synuclein-associated protein, in neurodegenerative disorders.Acta neuropathologica, , Volume: 103, Issue:3, 2002
Biochemical characterization of the core structure of alpha-synuclein filaments.The Journal of biological chemistry, , May-24, Volume: 277, Issue:21, 2002
Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease.Science (New York, N.Y.), , Feb-01, Volume: 295, Issue:5556, 2002
alpha-Synuclein is phosphorylated in synucleinopathy lesions.Nature cell biology, , Volume: 4, Issue:2, 2002
The synucleins.Genome biology, , Volume: 3, Issue:1, 2002
Tubulin seeds alpha-synuclein fibril formation.The Journal of biological chemistry, , Jan-18, Volume: 277, Issue:3, 2002
Familial Lewy body diseases.Journal of geriatric psychiatry and neurology, ,Winter, Volume: 15, Issue:4, 2002
Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies.The Journal of clinical investigation, , Volume: 110, Issue:10, 2002
Parkinson's disease and related synucleinopathies are a new class of nervous system amyloidoses.Neurotoxicology, , Volume: 23, Issue:4-5, 2002
Mice expressing the alpha(1B)-adrenergic receptor induces a synucleinopathy with excessive tyrosine nitration but decreased phosphorylation.Journal of neurochemistry, , Volume: 83, Issue:3, 2002
The neuropathogenic contributions of lysosomal dysfunction.Journal of neurochemistry, , Volume: 83, Issue:3, 2002
Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions.The Journal of biological chemistry, , Dec-13, Volume: 277, Issue:50, 2002
Evidence that alpha-synuclein functions as a negative regulator of Ca(++)-dependent alpha-granule release from human platelets.Blood, , Oct-01, Volume: 100, Issue:7, 2002
The prion protein in human neurodegenerative disorders.Neuroscience letters, , Sep-06, Volume: 329, Issue:3, 2002
The effects of aggregation-inducing motifs on amyloid formation of model proteins related to neurodegenerative diseases.Biochemistry, , Aug-13, Volume: 41, Issue:32, 2002
Production of reactive oxygen species from aggregating proteins implicated in Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases.Current topics in medicinal chemistry, , Volume: 1, Issue:6, 2001
beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor.Neuron, , Oct-25, Volume: 32, Issue:2, 2001
Expression of beta-synuclein in normal human astrocytes.Neuroreport, , Sep-17, Volume: 12, Issue:13, 2001
Induction of alpha-synuclein aggregation by intracellular nitrative insult.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Oct-15, Volume: 21, Issue:20, 2001
Glial cell death induced by overexpression of alpha-synuclein.Journal of neuroscience research, , Sep-01, Volume: 65, Issue:5, 2001
Membrane binding and self-association of alpha-synucleins.Biochemistry, , Aug-21, Volume: 40, Issue:33, 2001
Genomic organization, chromosome location, and expression analysis of mouse beta-synuclein, a candidate for involvement in neurodegeneration.Cytogenetics and cell genetics, , Volume: 93, Issue:1-2, 2001
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A review on the cause-effect relationship between oxidative stress and toxic proteins in the pathogenesis of neurodegenerative diseases.Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, , Volume: 118, Issue:1
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Dual pathology of corticobasal degeneration and Parkinson's disease in a patient with clinical features of progressive supranuclear palsy.Neurology India, , Volume: 59, Issue:6
Alpha-synuclein stimulation of astrocytes: Potential role for neuroinflammation and neuroprotection.Oxidative medicine and cellular longevity, , Volume: 3, Issue:4
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The expanding realm of prion phenomena in neurodegenerative disease.Prion, , Volume: 3, Issue:2
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Beta-synuclein gene alterations in dementia with Lewy bodies.Neurology, , Sep-14, Volume: 63, Issue:5, 2004
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[Inheritance mechnisam of gene SNCA for alcohol dependence].Yi chuan = Hereditas, , Volume: 32, Issue:11, 2010
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Alpha-synuclein is strategically positioned for afferent modulation of midbrain dopamine neurons and is essential for cocaine preference.Communications biology, , Volume: 2, 2019
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Cocaine abuse elevates alpha-synuclein and dopamine transporter levels in the human striatum.Neuroreport, , Sep-08, Volume: 16, Issue:13, 2005
Cocaine abusers have an overexpression of alpha-synuclein in dopamine neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Apr-01, Volume: 23, Issue:7, 2003
An α-synuclein gene (SNCA) polymorphism moderates the association of PTSD symptomatology with hazardous alcohol use, but not with aggression-related measures.Journal of anxiety disorders, , Volume: 30, 2015
The association of SNCA with hazardous alcohol use is mediated by impulsivity.Psychiatry research, , Apr-30, Volume: 226, Issue:2-3, 2015
From QTL to candidate gene: a genetic approach to alcoholism research.Current drug abuse reviews, , Volume: 2, Issue:2, 2009
Association between LAG3/CD4 gene variants and risk of Parkinson's disease.European journal of clinical investigation, , Volume: 52, Issue:11, 2022
Relationships of Nutritional Factors and Agrochemical Exposure with Parkinson's Disease in the Province of Brescia, Italy.International journal of environmental research and public health, , 03-11, Volume: 19, Issue:6, 2022
COQ2 and SNCA polymorphisms interact with environmental factors to modulate the risk of multiple system atrophy and subtype disposition.European journal of neurology, , Volume: 29, Issue:10, 2022
17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson's disease are associated with LRRC37A/2 expression in astrocytes.Molecular neurodegeneration, , 07-15, Volume: 17, Issue:1, 2022
Longitudinal Study of SNCA Rep1 Polymorphism on Executive Function in Early Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:3, 2022
Evaluating the role of ARSA in Chinese patients with Parkinson's disease.Neurobiology of aging, , Volume: 109, 2022
Polygenic risk prediction and SNCA haplotype analysis in a Latino Parkinson's disease cohort.Parkinsonism & related disorders, , Volume: 102, 2022
SNCA 3' UTR Genetic Variants in Patients with Parkinson's Disease.Biomolecules, , 11-30, Volume: 11, Issue:12, 2021
Clinical and molecular genetic findings of hereditary Parkinson's patients from Turkey.Parkinsonism & related disorders, , Volume: 93, 2021
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture.Nature genetics, , Volume: 53, Issue:3, 2021
Mechanisms of Neurodegeneration in Various Forms of Parkinsonism-Similarities and Differences.Cells, , 03-16, Volume: 10, Issue:3, 2021
α-syn and SNP rs356219 as a potential biomarker in blood for Parkinson's disease in Mexican Mestizos.Neuroscience letters, , 05-29, Volume: 754, 2021
Parkinson's disease risk genes act in glia to control neuronal α-synuclein toxicity.Neurobiology of disease, , Volume: 159, 2021
Interaction between SNCA gene polymorphisms and T2DM with Parkinson's disease.Acta neurologica Scandinavica, , Volume: 142, Issue:5, 2020
Clinical characterization of patients with leucine-rich repeat kinase 2 genetic variants in Japan.Journal of human genetics, , Volume: 65, Issue:9, 2020
CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson's disease: a study in LRRK2 mutation carriers.Translational neurodegeneration, , 05-06, Volume: 9, Issue:1, 2020
SNPs in SNCA, MCCC1, DLG2, GBF1 and MBNL2 are associated with Parkinson's disease in southern Chinese population.Journal of cellular and molecular medicine, , Volume: 24, Issue:15, 2020
Protein transmission in neurodegenerative disease.Nature reviews. Neurology, , Volume: 16, Issue:4, 2020
Fine-Mapping of SNCA in Rapid Eye Movement Sleep Behavior Disorder and Overt Synucleinopathies.Annals of neurology, , Volume: 87, Issue:4, 2020
The biochemical basis of interactions between Glucocerebrosidase and alpha-synuclein in GBA1 mutation carriers.Journal of neurochemistry, , Volume: 154, Issue:1, 2020
Enhancing the Activity of Glucocerebrosidase as a Treatment for Parkinson Disease.CNS drugs, , Volume: 34, Issue:9, 2020
Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult.Neuron, , 03-04, Volume: 105, Issue:5, 2020
Emerging Targeted Therapeutics for Genetic Subtypes of Parkinsonism.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 17, Issue:4, 2020
Association between SNCA rs356220 polymorphism and Parkinson's disease: A meta-analysis.Neuroscience letters, , 01-19, Volume: 717, 2020
Association between alpha-synuclein (SNCA) rs11931074 variability and susceptibility to Parkinson's disease: an updated meta-analysis of 41,811 patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 41, Issue:2, 2020
SNCA-Rep1 polymorphism correlates with susceptibility and iron deficiency in restless legs syndrome.Parkinsonism & related disorders, , Volume: 81, 2020
Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia.Brain : a journal of neurology, , 01-01, Volume: 143, Issue:1, 2020
Assessment of risk factor variants of LRRK2, MAPT, SNCA and TCEANC2 genes in Hungarian sporadic Parkinson's disease patients.Neuroscience letters, , 07-27, Volume: 706, 2019
Family-based association study on functional α-synuclein polymorphisms in attention-deficit/hyperactivity disorder.Attention deficit and hyperactivity disorders, , Volume: 11, Issue:1, 2019
SNCA and mTOR Pathway Single Nucleotide Polymorphisms Interact to Modulate the Age at Onset of Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:9, 2019
SMPD1 mutations, activity, and α-synuclein accumulation in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:4, 2019
Synaptic, Mitochondrial, and Lysosomal Dysfunction in Parkinson's Disease.Trends in neurosciences, , Volume: 42, Issue:2, 2019
Proteomics; applications in familial Parkinson's disease.Journal of neurochemistry, , Volume: 151, Issue:4, 2019
SNCA rs11931074 polymorphism correlates with spontaneous brain activity and motor symptoms in Chinese patients with Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 126, Issue:8, 2019
Regional transcriptional architecture of Parkinson's disease pathogenesis and network spread.Brain : a journal of neurology, , 10-01, Volume: 142, Issue:10, 2019
Parkinson's disease: a short story of 200 years.Histology and histopathology, , Volume: 34, Issue:6, 2019
Association of rs356219 and rs3822086 polymorphisms with the risk of Parkinson's disease: A meta-analysis.Neuroscience letters, , 09-14, Volume: 709, 2019
Genetic variants of PARK genes in Korean patients with early-onset Parkinson's disease.Neurobiology of aging, , Volume: 75, 2019
Alpha-synuclein gene polymorphism affects risk of dementia in Han Chinese with Parkinson's disease.Neuroscience letters, , 07-27, Volume: 706, 2019
Association of the Polygenic Risk Score with the Incidence Risk of Parkinson's Disease and Cerebrospinal Fluid α-Synuclein in a Chinese Cohort.Neurotoxicity research, , Volume: 36, Issue:3, 2019
Low prevalence of known pathogenic mutations in dominant PD genes: A Swedish multicenter study.Parkinsonism & related disorders, , Volume: 66, 2019
Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:6, 2019
Cross-examining candidate genes implicated in multiple system atrophy.Acta neuropathologica communications, , 07-24, Volume: 7, Issue:1, 2019
Twendee X Ameliorates Phosphorylated Tau, α-Synuclein and Neurovascular Dysfunction in Alzheimer's Disease Transgenic Mice With Chronic Cerebral Hypoperfusion.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, , Volume: 28, Issue:10, 2019
Interpreting Genetic Variants: Hints from a Family Cluster of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 9, Issue:1, 2019
Common genetic variants associated with Parkinson's disease display widespread signature of epigenetic plasticity.Scientific reports, , 12-05, Volume: 9, Issue:1, 2019
Functionalization of the TMEM175 p.M393T variant as a risk factor for Parkinson disease.Human molecular genetics, , 10-01, Volume: 28, Issue:19, 2019
Diagnostic biomarkers for Parkinson's disease at a glance: where are we?Journal of neural transmission (Vienna, Austria : 1996), , Volume: 125, Issue:10, 2018
SNCA REP1 and Parkinson's disease.Neuroscience letters, , 08-24, Volume: 682, 2018
Genetics of Parkinson disease.Handbook of clinical neurology, , Volume: 147, 2018
miR-486-3p Influences the Neurotoxicity of a-Synuclein by Targeting the SIRT2 Gene and the Polymorphisms at Target Sites Contributing to Parkinson's Disease.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , Volume: 51, Issue:6, 2018
Toward deciphering the mechanistic role of variations in the Rep1 repeat site in the transcription regulation of SNCA gene.Neurogenetics, , Volume: 19, Issue:3, 2018
Bone loss in C57BL/6J-OlaHsd mice, a substrain of C57BL/6J carrying mutated alpha-synuclein and multimerin-1 genes.Journal of cellular physiology, , Volume: 233, Issue:1, 2018
Insights into the Molecular Mechanisms of Alzheimer's and Parkinson's Diseases with Molecular Simulations: Understanding the Roles of Artificial and Pathological Missense Mutations in Intrinsically Disordered Proteins Related to Pathology.International journal of molecular sciences, , Jan-24, Volume: 19, Issue:2, 2018
An updated analysis with 45,078 subjects confirms the association between SNCA rs11931074 and Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 39, Issue:12, 2018
Parkinson-Associated SNCA Enhancer Variants Revealed by Open Chromatin in Mouse Dopamine Neurons.American journal of human genetics, , 12-06, Volume: 103, Issue:6, 2018
SNCA variants and alpha-synuclein level in CD45+ blood cells in Parkinson's disease.Journal of the neurological sciences, , 12-15, Volume: 395, 2018
Risk variants of the α-synuclein locus and REM sleep behavior disorder in Parkinson's disease: a genetic association study.BMC neurology, , Feb-21, Volume: 18, Issue:1, 2018
MDSGene: Closing Data Gaps in Genotype-Phenotype Correlations of Monogenic Parkinson's Disease.Journal of Parkinson's disease, , Volume: 8, Issue:s1, 2018
A comprehensive analysis of SNCA-related genetic risk in sporadic parkinson disease.Annals of neurology, , Volume: 84, Issue:1, 2018
The implication of neuronimmunoendocrine (NIE) modulatory network in the pathophysiologic process of Parkinson's disease.Cellular and molecular life sciences : CMLS, , Volume: 74, Issue:20, 2017
Association between gene polymorphism and depression in Parkinson's disease: A case-control study.Journal of the neurological sciences, , Apr-15, Volume: 375, 2017
Imaging genetics approach to Parkinson's disease and its correlation with clinical score.Scientific reports, , 04-21, Volume: 7, 2017
Epidemiology, environmental risk factors and genetics of Parkinson's disease.Presse medicale (Paris, France : 1983), , Volume: 46, Issue:2 Pt 1, 2017
TMEM230 in Parkinson's disease.Neurobiology of aging, , Volume: 56, 2017
Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.Disease models & mechanisms, , 05-01, Volume: 10, Issue:5, 2017
The Birth of the Modern Era of Parkinson's Disease Genetics.Journal of Parkinson's disease, , Volume: 7, Issue:s1, 2017
Association between SNCA rs2736990 polymorphism and Parkinson's disease: a meta-analysis.Neuroscience letters, , Sep-29, Volume: 658, 2017
Epigenetic approach to early-onset Parkinson's disease: low methylation status of SNCA and PARK2 promoter regions.Neurological research, , Volume: 39, Issue:11, 2017
Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing.Genome biology, , 01-30, Volume: 18, Issue:1, 2017
Allelic difference in Mhc2ta confers altered microglial activation and susceptibility to α-synuclein-induced dopaminergic neurodegeneration.Neurobiology of disease, , Volume: 106, 2017
Structural genomic variations and Parkinson's disease.Minerva medica, , Volume: 108, Issue:5, 2017
Finding the 'Guilty' Gene Variant of Sporadic Parkinson's Disease Via CRISPR/Cas9.Neuroscience bulletin, , Volume: 33, Issue:1, 2017
mTOR Signaling in Parkinson's Disease.Neuromolecular medicine, , Volume: 19, Issue:1, 2017
The analysis of association between SNCA, HUSEYO and CSMD1 gene variants and Parkinson's disease in Iranian population.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 37, Issue:5, 2016
MAPT haplotype diversity in multiple system atrophy.Parkinsonism & related disorders, , Volume: 30, 2016
[Frequency of single nucleotide polymorphisms and alpha-synuclein haplotypes associated with sporadic Parkinson's disease in the Mexican population].Revista de neurologia, , Oct-16, Volume: 63, Issue:8, 2016
The rs3756063 polymorphism is associated with SNCA methylation in the Chinese Han population.Journal of the neurological sciences, , Aug-15, Volume: 367, 2016
A53T in a parkinsonian family: a clinical update of the SNCA phenotypes.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 123, Issue:11, 2016
Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression.Nature, , May-05, Volume: 533, Issue:7601, 2016
Parkinson's disease: Guilt by genetic association.Nature, , May-05, Volume: 533, Issue:7601, 2016
Beyond Krabbe's disease: The potential contribution of galactosylceramidase deficiency to neuronal vulnerability in late-onset synucleinopathies.Journal of neuroscience research, , Volume: 94, Issue:11, 2016
Resequencing analysis of five Mendelian genes and the top genes from genome-wide association studies in Parkinson's Disease.Molecular neurodegeneration, , Apr-19, Volume: 11, 2016
α-synuclein genetic variability: A biomarker for dementia in Parkinson disease.Annals of neurology, , Volume: 79, Issue:6, 2016
The Parkinson Disease gene SNCA: Evolutionary and structural insights with pathological implication.Scientific reports, , Apr-15, Volume: 6, 2016
The rs3857059 variant of the SNCA gene is associated with Parkinson's disease in Mexican Mestizos.Arquivos de neuro-psiquiatria, , Volume: 74, Issue:6, 2016
Comprehensive analysis of genome-wide DNA methylation across human polycystic ovary syndrome ovary granulosa cell.Oncotarget, , May-10, Volume: 7, Issue:19, 2016
Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.Proceedings of the National Academy of Sciences of the United States of America, , 10-18, Volume: 113, Issue:42, 2016
SNCA rs356182 variant increases risk of sporadic Parkinson's disease in ethnic Chinese.Journal of the neurological sciences, , Sep-15, Volume: 368, 2016
Chronic mild stress accelerates the progression of Parkinson's disease in A53T α-synuclein transgenic mice.Experimental neurology, , Volume: 285, Issue:Pt A, 2016
Genetics of Parkinson's disease.Molecular and cellular probes, , Volume: 30, Issue:6, 2016
Cutaneous malignant melanoma and Parkinson disease: Common pathways?Annals of neurology, , Volume: 80, Issue:6, 2016
Synaptotagmin XI in Parkinson's disease: New evidence from an association study in Spain and Mexico.Journal of the neurological sciences, , Mar-15, Volume: 362, 2016
Salivary total α-synuclein, oligomeric α-synuclein and SNCA variants in Parkinson's disease patients.Scientific reports, , 06-23, Volume: 6, 2016
Role for the microtubule-associated protein tau variant p.A152T in risk of α-synucleinopathies.Neurology, , Nov-10, Volume: 85, Issue:19, 2015
SNCA rs3822086 C>T Polymorphism Increases the Susceptibility to Parkinson's Disease in a Chinese Han Population.Genetic testing and molecular biomarkers, , Volume: 19, Issue:9, 2015
Genetic Variants of SNCA Are Associated with Susceptibility to Parkinson's Disease but Not Amyotrophic Lateral Sclerosis or Multiple System Atrophy in a Chinese Population.PloS one, , Volume: 10, Issue:7, 2015
Alpha-synuclein A53T mutation is not frequent on a sample of Brazilian Parkinson's disease patients.Arquivos de neuro-psiquiatria, , Volume: 73, Issue:6, 2015
Alpha-synuclein (SNCA) polymorphisms and susceptibility to Parkinson's disease: a meta-analysis.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, , Volume: 168B, Issue:2, 2015
Neuroinflammation in Lewy body dementia.Parkinsonism & related disorders, , Volume: 21, Issue:12, 2015
Parkinson's disease correlates with promoter methylation in the α-synuclein gene.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:4, 2015
SNP rs11931074 of the SNCA gene may not be associated with multiple system atrophy in Chinese population.The International journal of neuroscience, , Volume: 125, Issue:8, 2015
SNCA Gene, but Not MAPT, Influences Onset Age of Parkinson's Disease in Chinese and Australians.BioMed research international, , Volume: 2015, 2015
Analysis of Parkinson's disease brain-derived DNA for alpha-synuclein coding somatic mutations.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:8, 2014
Genetic causes of Parkinson's disease and their links to autophagy regulation.Parkinsonism & related disorders, , Volume: 20 Suppl 1, 2014
APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease.JAMA neurology, , Volume: 71, Issue:11, 2014
Hypomethylation of SNCA in blood of patients with sporadic Parkinson's disease.Journal of the neurological sciences, , Feb-15, Volume: 337, Issue:1-2, 2014
Accurate prediction of a minimal region around a genetic association signal that contains the causal variant.European journal of human genetics : EJHG, , Volume: 22, Issue:2, 2014
Protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants.Neurobiology of aging, , Volume: 35, Issue:1, 2014
LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis.Experimental neurology, , Volume: 261, 2014
SNCA variants rs2736990 and rs356220 as risk factors for Parkinson's disease but not for amyotrophic lateral sclerosis and multiple system atrophy in a Chinese population.Neurobiology of aging, , Volume: 35, Issue:12, 2014
Alpha-synuclein transcript isoforms in three different brain regions from Parkinson's disease and healthy subjects in relation to the SNCA rs356165/rs11931074 polymorphisms.Neuroscience letters, , Mar-06, Volume: 562, 2014
A 6.4 Mb duplication of the α-synuclein locus causing frontotemporal dementia and Parkinsonism: phenotype-genotype correlations.JAMA neurology, , Volume: 71, Issue:9, 2014
α-Synuclein rs356219 polymorphisms in patients with Gaucher disease and Parkinson disease.Neuroscience letters, , Sep-19, Volume: 580, 2014
Alpha-synuclein repeat variants and survival in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:8, 2014
Genetic susceptibility loci, environmental exposures, and Parkinson's disease: a case-control study of gene-environment interactions.Parkinsonism & related disorders, , Volume: 19, Issue:6, 2013
The association between ß-glucocerebrosidase mutations and parkinsonism.Current neurology and neuroscience reports, , Volume: 13, Issue:8, 2013
Genetic influences on craving for alcohol.Addictive behaviors, , Volume: 38, Issue:2, 2013
SNCA, LRRK2, MAPT polymorphisms and Parkinson's disease in Russia.Parkinsonism & related disorders, , Volume: 19, Issue:11, 2013
[Neurotoxicity of pesticides: its relationship with neurodegenerative diseases].Medecine sciences : M/S, , Volume: 29, Issue:3, 2013
SNCA rs356219 variant increases risk of sporadic Parkinson's disease in ethnic Chinese.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, , Volume: 162B, Issue:5, 2013
Behavioral testing regimens in genetic-based animal models of Parkinson's disease: cogencies and caveats.Neuroscience and biobehavioral reviews, , Volume: 37, Issue:5, 2013
MAPT H1 haplotype is associated with enhanced α-synuclein deposition in dementia with Lewy bodies.Neurobiology of aging, , Volume: 34, Issue:3, 2013
Somatic alpha-synuclein mutations in Parkinson's disease: hypothesis and preliminary data.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:6, 2013
Genetic variants of SNCA and LRRK2 genes are associated with sporadic PD susceptibility: a replication study in a Taiwanese cohort.Parkinsonism & related disorders, , Volume: 19, Issue:2, 2013
Parkinson disease: from pathology to molecular disease mechanisms.Free radical biology & medicine, , Volume: 62, 2013
The genetics of Parkinson's disease: progress and therapeutic implications.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:1, 2013
Molecular pathogenesis of Parkinson's disease: update.Journal of neurology, neurosurgery, and psychiatry, , Volume: 83, Issue:4, 2012
Variant in the 3' region of SNCA associated with Parkinson's disease and serum α-synuclein levels.Journal of neurology, , Volume: 259, Issue:3, 2012
Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-08, Volume: 32, Issue:6, 2012
Emerging neurotoxic mechanisms in environmental factors-induced neurodegeneration.Neurotoxicology, , Volume: 33, Issue:4, 2012
SNCA and MAPT genes: Independent and joint effects in Parkinson disease in the Italian population.Parkinsonism & related disorders, , Volume: 18, Issue:3, 2012
SNP rs356219 of the α-synuclein (SNCA) gene is associated with Parkinson's disease in a Chinese Han population.Parkinsonism & related disorders, , Volume: 18, Issue:5, 2012
Genetic and pathological links between Parkinson's disease and the lysosomal disorder Sanfilippo syndrome.Movement disorders : official journal of the Movement Disorder Society, , Volume: 27, Issue:2, 2012
A search for SNCA 3' UTR variants identified SNP rs356165 as a determinant of disease risk and onset age in Parkinson's disease.Journal of molecular neuroscience : MN, , Volume: 47, Issue:3, 2012
SNCA polymorphisms, smoking, and sporadic Parkinson's disease in Japanese.Parkinsonism & related disorders, , Volume: 18, Issue:5, 2012
Analysis of LRRK2, SNCA, Parkin, PINK1, and DJ-1 in Zambian patients with Parkinson's disease.Parkinsonism & related disorders, , Volume: 18, Issue:5, 2012
Autosomal dominant parkinsonism: its etiologies and differential diagnoses.Parkinsonism & related disorders, , Volume: 18 Suppl 1, 2012
The genetics and neuropathology of Parkinson's disease.Acta neuropathologica, , Volume: 124, Issue:3, 2012
A DNA resequencing array for genes involved in Parkinson's disease.Parkinsonism & related disorders, , Volume: 18, Issue:4, 2012
Update on genetics of parkinsonism.Neuro-degenerative diseases, , Volume: 10, Issue:1-4, 2012
[Neurodegeneration and epigenetics].Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, , Volume: 32, Issue:5-6, 2012
Converging environmental and genetic pathways in the pathogenesis of Parkinson's disease.Journal of the neurological sciences, , Jul-15, Volume: 306, Issue:1-2, 2011
Genome-wide association study confirms extant PD risk loci among the Dutch.European journal of human genetics : EJHG, , Volume: 19, Issue:6, 2011
Do interactions between SNCA, MAPT, and LRRK2 genes contribute to Parkinson's disease susceptibility?Parkinsonism & related disorders, , Volume: 17, Issue:10, 2011
Independent and joint effects of the MAPT and SNCA genes in Parkinson disease.Annals of neurology, , Volume: 69, Issue:5, 2011
Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21.Human molecular genetics, , Jan-15, Volume: 20, Issue:2, 2011
Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:12, 2011
Convergence of miRNA expression profiling, α-synuclein interacton and GWAS in Parkinson's disease.PloS one, , Volume: 6, Issue:10, 2011
The effect of SNCA 3' region on the levels of SNCA-112 splicing variant.Neurogenetics, , Volume: 12, Issue:1, 2011
Common variants in PARK loci and related genes and Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Feb-01, Volume: 26, Issue:2, 2011
Replication of MAPT and SNCA, but not PARK16-18, as susceptibility genes for Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:5, 2011
SNCA locus duplication carriers: from genetics to Parkinson disease phenotypes.Human mutation, , Volume: 32, Issue:4, 2011
The curious case of phenocopies in families with genetic Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Aug-15, Volume: 26, Issue:10, 2011
Interaction between α-synuclein and tau genotypes and the progression of Parkinson's disease.Journal of Parkinson's disease, , Volume: 1, Issue:3, 2011
Genetic variability in SNCA and Parkinson's disease.Neurogenetics, , Volume: 12, Issue:4, 2011
Genetic variants of α-synuclein are not associated with essential tremor.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:14, 2011
From GWAS to clinical utility in Parkinson's disease.Lancet (London, England), , Feb-19, Volume: 377, Issue:9766, 2011
Unravelling the role of defective genes.Progress in brain research, , Volume: 183, 2010
The genetics of Parkinson disease.Journal of geriatric psychiatry and neurology, , Volume: 23, Issue:4, 2010
Clinical implications of gene discovery in Parkinson's disease and parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Volume: 25 Suppl 1, 2010
Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update.Human mutation, , Volume: 31, Issue:7, 2010
alpha-Synuclein multiplication analysis in Italian familial Parkinson disease.Parkinsonism & related disorders, , Volume: 16, Issue:3, 2010
Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains.The Journal of neuroscience : the official journal of the Society for Neuroscience, , May-05, Volume: 30, Issue:18, 2010
Are genetic and sporadic Parkinson's disease patients equally susceptible to develop dementia?Journal of the neurological sciences, , Feb-15, Volume: 289, Issue:1-2, 2010
Stimulated dopamine overflow and alpha-synuclein expression in the nucleus accumbens core distinguish rats bred for differential ethanol preference.Journal of neurochemistry, , Volume: 114, Issue:4, 2010
Reply to: SNCA variants are associated with increased risk of multiple system atrophy.Annals of neurology, , Volume: 67, Issue:3, 2010
Genetic analysis of pathways to Parkinson disease.Neuron, , Oct-21, Volume: 68, Issue:2, 2010
SNCA variant associated with Parkinson disease and plasma alpha-synuclein level.Archives of neurology, , Volume: 67, Issue:11, 2010
Genetic basis of Parkinson disease.Neurosurgical focus, , Volume: 28, Issue:1, 2010
Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau.BioEssays : news and reviews in molecular, cellular and developmental biology, , Volume: 32, Issue:3, 2010
Association of alpha-, beta-, and gamma-Synuclein with diffuse lewy body disease.Archives of neurology, , Volume: 67, Issue:8, 2010
Identifying PD-causing genes and genetic susceptibility factors: current approaches and future prospects.Progress in brain research, , Volume: 183, 2010
Analysis of GWAS-linked loci in Parkinson disease reaffirms PARK16 as a susceptibility locus.Neurology, , Aug-10, Volume: 75, Issue:6, 2010
[Gene for sporadic Parkinson's disease: common disease-common variants].Rinsho shinkeigaku = Clinical neurology, , Volume: 50, Issue:11, 2010
CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease.PloS one, , Nov-24, Volume: 5, Issue:11, 2010
SNCA variants and multiple system atrophy.Annals of neurology, , Volume: 67, Issue:4, 2010
The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease.Nature reviews. Neuroscience, , Volume: 11, Issue:12, 2010
Expanding the clinical phenotype of SNCA duplication carriers.Movement disorders : official journal of the Movement Disorder Society, , Sep-15, Volume: 24, Issue:12, 2009
Genetic susceptibility in Parkinson's disease.Biochimica et biophysica acta, , Volume: 1792, Issue:7, 2009
Alpha-synuclein, alcohol use disorders, and Parkinson disease: a case-control study.Parkinsonism & related disorders, , Volume: 15, Issue:6, 2009
SNCA variants are associated with increased risk for multiple system atrophy.Annals of neurology, , Volume: 65, Issue:5, 2009
Parkinson's disease.Lancet (London, England), , Jun-13, Volume: 373, Issue:9680, 2009
A single nucleotide polymorphism in the 3'UTR of the SNCA gene encoding alpha-synuclein is a new potential susceptibility locus for Parkinson disease.Neuroscience letters, , Sep-18, Volume: 461, Issue:2, 2009
alpha-synuclein and LRRK2: partners in crime.Neuron, , Dec-24, Volume: 64, Issue:6, 2009
[Genetics and present therapy options in Parkinson's disease: a review].Ideggyogyaszati szemle, , May-30, Volume: 62, Issue:5-6, 2009
The association between mutations in the lysosomal protein glucocerebrosidase and parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Aug-15, Volume: 24, Issue:11, 2009
Alpha-synuclein gene rearrangements in dominantly inherited parkinsonism: frequency, phenotype, and mechanisms.Archives of neurology, , Volume: 66, Issue:1, 2009
The genetics of Parkinson's syndromes: a critical review.Current opinion in genetics & development, , Volume: 19, Issue:3, 2009
Effects of UCH-L1 on alpha-synuclein over-expression mouse model of Parkinson's disease.Journal of neurochemistry, , Volume: 108, Issue:4, 2009
Alpha-synuclein and familial Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Jun-15, Volume: 24, Issue:8, 2009
Etiology and pathogenesis of Parkinson disease.Neurologic clinics, , Volume: 27, Issue:3, 2009
Genomewide association study for susceptibility genes contributing to familial Parkinson disease.Human genetics, , Volume: 124, Issue:6, 2009
From genes to proteins in mendelian Parkinson's disease: an overview.Anatomical record (Hoboken, N.J. : 2007), , Volume: 292, Issue:12, 2009
Alpha-synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population.Movement disorders : official journal of the Movement Disorder Society, , Dec-15, Volume: 24, Issue:16, 2009
Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease.Experimental neurology, , Volume: 218, Issue:2, 2009
Parkinson's disease: from monogenic forms to genetic susceptibility factors.Human molecular genetics, , Apr-15, Volume: 18, Issue:R1, 2009
Enhanced alpha-synuclein expression in human neurodegenerative diseases: pathogenetic and therapeutic implications.Current protein & peptide science, , Volume: 10, Issue:5, 2009
Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.Neuron, , Dec-24, Volume: 64, Issue:6, 2009
The therapeutic potential of LRRK2 and alpha-synuclein in Parkinson's disease.Antioxidants & redox signaling, , Volume: 11, Issue:9, 2009
Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease?Movement disorders : official journal of the Movement Disorder Society, , Apr-30, Volume: 24, Issue:6, 2009
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.Nature genetics, , Volume: 41, Issue:12, 2009
Familial Parkinsonism and early onset Parkinson's disease in a Brazilian movement disorders clinic: phenotypic characterization and frequency of SNCA, PRKN, PINK1, and LRRK2 mutations.Movement disorders : official journal of the Movement Disorder Society, , Apr-15, Volume: 24, Issue:5, 2009
Neurotoxic conversion of beta-synuclein: a novel approach to generate a transgenic mouse model of synucleinopathies?Journal of neurology, , Volume: 256 Suppl 3, 2009
Review: Familial Parkinson's disease--genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease.Neuropathology and applied neurobiology, , Volume: 34, Issue:3, 2008
Genomic investigation of alpha-synuclein multiplication and parkinsonism.Annals of neurology, , Volume: 63, Issue:6, 2008
Progress in the pathogenesis and genetics of Parkinson's disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences, , Jun-27, Volume: 363, Issue:1500, 2008
Genetic association between alpha-synuclein and idiopathic Parkinson's disease.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, , Oct-05, Volume: 147B, Issue:7, 2008
High level of alpha-synuclein mRNA in peripheral lymphocytes of patients with alcohol dependence syndrome.Bulletin of experimental biology and medicine, , Volume: 146, Issue:5, 2008
Multiple alpha-synuclein gene polymorphisms are associated with Parkinson's disease in a Norwegian population.Acta neurologica Scandinavica, , Volume: 118, Issue:5, 2008
Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein.American journal of human genetics, , Volume: 82, Issue:2, 2008
Cerebellar alpha-synuclein levels are decreased in Parkinson's disease and do not correlate with SNCA polymorphisms associated with disease in a Swedish material.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 22, Issue:10, 2008
Analysis of Parkinson disease patients from Portugal for mutations in SNCA, PRKN, PINK1 and LRRK2.BMC neurology, , Jan-22, Volume: 8, 2008
Exploring gene-environment interactions in Parkinson's disease.Human genetics, , Volume: 123, Issue:3, 2008
Clinicopathologic study of a SNCA gene duplication patient with Parkinson disease and dementia.Neurology, , Jan-15, Volume: 70, Issue:3, 2008
Oxidative-stress-induced apoptosis in PBLs of two patients with Parkinson disease secondary to alpha-synuclein mutation.Journal of the neurological sciences, , Apr-15, Volume: 267, Issue:1-2, 2008
Mutations in progranulin gene: clinical, pathological, and ribonucleic acid expression findings.Biological psychiatry, , May-15, Volume: 63, Issue:10, 2008
Emerging pathways in genetic Parkinson's disease.The FEBS journal, , Volume: 275, Issue:23, 2008
Neurofibrillary tau pathology modulated by genetic variation of alpha-synuclein.Annals of neurology, , Volume: 64, Issue:3, 2008
Fas-associated factor 1 and Parkinson's disease.Neurobiology of disease, , Volume: 31, Issue:3, 2008
Impact of recent genetic findings in Parkinson's disease.Current opinion in neurology, , Volume: 20, Issue:4, 2007
Genetics of Parkinson's disease and parkinsonism.Expert review of neurotherapeutics, , Volume: 7, Issue:6, 2007
Autosomal dominant Parkinson's disease and the route to new therapies.Expert review of neurotherapeutics, , Volume: 7, Issue:6, 2007
Multiplex families with multiple system atrophy.Archives of neurology, , Volume: 64, Issue:4, 2007
Clinical genetics of Parkinson's disease and related disorders.Parkinsonism & related disorders, , Volume: 13 Suppl 3, 2007
Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication.Neurology, , Mar-20, Volume: 68, Issue:12, 2007
Parkinson's disease.Human molecular genetics, , Oct-15, Volume: 16 Spec No. 2, 2007
Association of alpha-synuclein gene haplotypes with Parkinson's disease.Parkinsonism & related disorders, , Volume: 13, Issue:6, 2007
alpha-Synuclein and Parkinson disease susceptibility.Neurology, , Oct-30, Volume: 69, Issue:18, 2007
Parkinson's disease genetic mutations increase cell susceptibility to stress: mutant alpha-synuclein enhances H2O2- and Sin-1-induced cell death.Neurobiology of aging, , Volume: 28, Issue:11, 2007
A 75-year-old man with cognitive impairment and gait changes.Neurology, , Sep-11, Volume: 69, Issue:11, 2007
[Molecular genetics of Parkinson's disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 59, Issue:8, 2007
Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease.Annals of neurology, , Volume: 62, Issue:2, 2007
Biochemical and pathological characterization of Lrrk2.Annals of neurology, , Volume: 59, Issue:2, 2006
Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients.Movement disorders : official journal of the Movement Disorder Society, , Volume: 21, Issue:10, 2006
alpha-Synuclein promoter RsaI T-to-C polymorphism and the risk of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 113, Issue:10, 2006
Ventral tegmental area dopamine neurons are resistant to human mutant alpha-synuclein overexpression.Neurobiology of disease, , Volume: 23, Issue:3, 2006
Parkinsonism genes: culprits and clues.Journal of neurochemistry, , Volume: 99, Issue:4, 2006
Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease.JAMA, , Aug-09, Volume: 296, Issue:6, 2006
Analysis of the polymorphic prion protein gene codon 129 in idiopathic Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 113, Issue:3, 2006
Behavioral effects of dopaminergic agonists in transgenic mice overexpressing human wildtype alpha-synuclein.Neuroscience, , Nov-03, Volume: 142, Issue:4, 2006
Evidence for novel loci for late-onset Parkinson's disease in a genetic isolate from the Netherlands.Human genetics, , Volume: 119, Issue:1-2, 2006
Association of alpha-synuclein Rep1 polymorphism and Parkinson's disease: influence of Rep1 on age at onset.Movement disorders : official journal of the Movement Disorder Society, , Volume: 21, Issue:4, 2006
Synphilin isoforms and the search for a cellular model of lewy body formation in Parkinson's disease.Cell cycle (Georgetown, Tex.), , Volume: 5, Issue:18, 2006
Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 20, Issue:12, 2006
Dementia with Lewy bodies in an elderly Greek male due to alpha-synuclein gene mutation.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, , Volume: 13, Issue:9, 2006
Molecular genetic pathways in Parkinson's disease: a review.Clinical science (London, England : 1979), , Volume: 109, Issue:4, 2005
Genetics of Parkinson's disease.Annals of medicine, , Volume: 37, Issue:2, 2005
Nosology of Parkinson's disease: looking for the way out of a quagmire.Neuron, , Aug-18, Volume: 47, Issue:4, 2005
New presenilin 1 mutation with Alzheimer disease and Lewy bodies.Archives of neurology, , Volume: 62, Issue:12, 2005
Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20, Issue:9, 2005
Novel presenilin 1 mutation (S170F) causing Alzheimer disease with Lewy bodies in the third decade of life.Archives of neurology, , Volume: 62, Issue:12, 2005
Abundant neuritic inclusions and microvacuolar changes in a case of diffuse Lewy body disease with the A53T mutation in the alpha-synuclein gene.Acta neuropathologica, , Volume: 110, Issue:3, 2005
Interaction of alpha-synuclein and tau genotypes in Parkinson's disease.Annals of neurology, , Volume: 57, Issue:3, 2005
Genetics of Parkinson's disease.Minerva medica, , Volume: 96, Issue:3, 2005
Genetic association between the APOE*4 allele and Lewy bodies in Alzheimer disease.Neurology, , Feb-08, Volume: 64, Issue:3, 2005
Australian data and meta-analysis lend support for alpha-synuclein (NACP-Rep1) as a risk factor for Parkinson's disease.Neuroscience letters, , Feb-28, Volume: 375, Issue:2, 2005
The role of alpha-synuclein gene multiplications in early-onset Parkinson's disease and dementia with Lewy bodies.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 112, Issue:9, 2005
No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found.Neuroscience letters, , Jun-10, Volume: 363, Issue:2, 2004
[The alpha-synuclein gene microsatellite polymorphism and late-onset sporadic Parkinson's disease susceptibility].Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, , Volume: 21, Issue:4, 2004
SNCA multiplication is not a common cause of Parkinson disease or dementia with Lewy bodies.Neurology, , Aug-10, Volume: 63, Issue:3, 2004
Beta-synuclein gene alterations in dementia with Lewy bodies.Neurology, , Sep-14, Volume: 63, Issue:5, 2004
Alpha-synuclein haplotypes implicated in risk of Parkinson's disease.Neurology, , Jan-13, Volume: 62, Issue:1, 2004
New aspects of genetic contributions to Parkinson's disease.Journal of molecular neuroscience : MN, , Volume: 24, Issue:3, 2004
NACP-REP1 polymorphism is not involved in Parkinson's disease: a case-control study in a population sample from southern Italy.Neuroscience letters, , Nov-13, Volume: 351, Issue:2, 2003
Haploinsufficiency at the alpha-synuclein gene underlies phenotypic severity in familial Parkinson's disease.Brain : a journal of neurology, , Volume: 126, Issue:Pt 1, 2003
Essential tremor is not associated with alpha-synuclein gene haplotypes.Movement disorders : official journal of the Movement Disorder Society, , Volume: 18, Issue:7, 2003
Complex interactions in Parkinson's disease: a two-phased approach.Movement disorders : official journal of the Movement Disorder Society, , Volume: 18, Issue:6, 2003
Case-control study of the alpha-synuclein interacting protein gene and Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 18, Issue:11, 2003
Alpha synuclein promoter and risk of Parkinson's disease: microsatellite and allelic size variability.Neuroscience letters, , Jan-09, Volume: 336, Issue:1, 2003
The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.Cell, , Oct-18, Volume: 111, Issue:2, 2002
Familial Lewy body diseases.Journal of geriatric psychiatry and neurology, ,Winter, Volume: 15, Issue:4, 2002
Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice.Experimental neurology, , Volume: 175, Issue:1, 2002
Analysis of the coding and the 5' flanking regions of the alpha-synuclein gene in patients with Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 16, Issue:6, 2001
Genetic studies in Parkinson's disease with an alpha-synuclein/NACP gene polymorphism in Japan.Neuroscience letters, , Mar-09, Volume: 300, Issue:2, 2001
Decreased platelet glutamate uptake and genetic risk factors in patients with Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 22, Issue:1, 2001
Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?Nature cell biology, , Volume: 2, Issue:7, 2000
Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity.Human molecular genetics, , Nov-01, Volume: 9, Issue:18, 2000
The alpha-synuclein gene is not a major risk factor in familial Parkinson disease.Neurogenetics, , Volume: 2, Issue:3, 1999
Genetic and environmental risk factors in Parkinson's disease.Clinical neurology and neurosurgery, , Volume: 100, Issue:1, 1998
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Familial genes in sporadic disease: common variants of alpha-synuclein gene associate with Parkinson's disease.Mechanisms of ageing and development, , Volume: 128, Issue:5-6
[Genetic factors associated with dementia in Parkinson's disease (PD)].Gaceta medica de Mexico, , Volume: 151, Issue:1
Molecular analysis of α-synuclein gene in Parkinson's disease in North Karnataka, India.Neurology India, , Volume: 62, Issue:2
Association of polymorphism in rs2736990 of the α-synuclein gene with Parkinson's disease in a Chinese population.Neurology India, , Volume: 61, Issue:4
A statistical and biological approach for identifying misdiagnosis of incipient Alzheimer patients using gene expression data.Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, , Volume: 2006
Manganese induced nervous injury by α-synuclein accumulation via ATP-sensitive K(+) channels and GABA receptors.Toxicology letters, , Oct-10, Volume: 332, 2020
Manganese Accumulation in the Brain via Various Transporters and Its Neurotoxicity Mechanisms.Molecules (Basel, Switzerland), , Dec-12, Volume: 25, Issue:24, 2020
α-Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinson's disease.Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 143, Issue:2, 2015
Oxidative stress involvement in manganese-induced alpha-synuclein oligomerization in organotypic brain slice cultures.Toxicology, , Mar-08, Volume: 305, 2013
From manganism to manganese-induced parkinsonism: a conceptual model based on the evolution of exposure.Neuromolecular medicine, , Volume: 11, Issue:4, 2009
[Differential diagnosis of RBD symptomatology (idiopathic RBD or RBD mimics)].Rinsho shinkeigaku = Clinical neurology, , Apr-25, Volume: 59, Issue:4, 2019
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[A case of severe obstructive sleep apnea mimicking REM sleep behavior disorder].Rinsho shinkeigaku = Clinical neurology, , Apr-25, Volume: 59, Issue:4, 2019
Increased α-synuclein levels in patients with sleep apnoea might be involved in PD pathogenesis.Nature reviews. Neurology, , Volume: 15, Issue:5, 2019
Depletion of putative chemosensitive respiratory neurons in the ventral medullary surface in multiple system atrophy.Brain : a journal of neurology, , Volume: 130, Issue:Pt 2, 2007
Oligomeric Alpha-Synuclein and STX-1A from Neural-Derived Extracellular Vesicles (NDEVs) as Possible Biomarkers of REM Sleep Behavior Disorder in Parkinson's Disease: A Preliminary Cohort Study.International journal of molecular sciences, , May-16, Volume: 24, Issue:10, 2023
Pharmacological interventions targeting α-synuclein aggregation triggered REM sleep behavior disorder and early development of Parkinson's disease.Pharmacology & therapeutics, , Volume: 249, 2023
Dermal Real-Time Quaking-Induced Conversion Is a Sensitive Marker to Confirm Isolated Rapid Eye Movement Sleep Behavior Disorder as an Early α-Synucleinopathy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:6, 2023
Accurate Detection of α-Synuclein Seeds in Cerebrospinal Fluid from Isolated Rapid Eye Movement Sleep Behavior Disorder and Patients with Parkinson's Disease in the DeNovo Parkinson (DeNoPa) Cohort.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:4, 2023
Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional study.The Lancet. Neurology, , Volume: 22, Issue:5, 2023
The brain-first vs. body-first model of Parkinson's disease with comparison to alternative models.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 130, Issue:6, 2023
Misfolded α-Synuclein Assessment in the Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorder.Neurology, , 05-02, Volume: 100, Issue:18, 2023
α-Synuclein Induced the Occurrence of RBD via Interaction with OX1R and Modulated Its Degradation.Neuromolecular medicine, , Volume: 25, Issue:2, 2023
Neuroinflammation and Immune Changes in Prodromal Parkinson's Disease and Other Synucleinopathies.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
Association between probable REM sleep behavior disorder and increased dermal alpha-synuclein deposition in Parkinson's disease.Parkinsonism & related disorders, , Volume: 99, 2022
Brain atrophy in prodromal synucleinopathy is shaped by structural connectivity and gene expression.Brain : a journal of neurology, , 09-14, Volume: 145, Issue:9, 2022
Idiopathic rapid eye movement sleep behavior disorder in Japan: An observational study.Parkinsonism & related disorders, , Volume: 103, 2022
REM sleep behavior disorder and cerebrospinal fluid alpha-synuclein, amyloid beta, total tau and phosphorylated tau in Parkinson's disease: a cross-sectional and longitudinal study.Journal of neurology, , Volume: 269, Issue:9, 2022
Associations of sleep disorders with cerebrospinal fluid α-synuclein in prodromal and early Parkinson's disease.Journal of neurology, , Volume: 269, Issue:5, 2022
Striatal-Inoculation of α-Synuclein Preformed Fibrils Aggravated the Phenotypes of REM Sleep without Atonia in A53T BAC-SNCA Transgenic Mice.International journal of molecular sciences, , Nov-02, Volume: 23, Issue:21, 2022
Clinical and imaging evidence of brain-first and body-first Parkinson's disease.Neurobiology of disease, , Volume: 164, 2022
Different patterns of exosomal α-synuclein between Parkinson's disease and probable rapid eye movement sleep behavior disorder.European journal of neurology, , Volume: 29, Issue:12, 2022
Relationship between Substantia Nigra Neuromelanin Imaging and Dual Alpha-Synuclein Labeling of Labial Minor in Salivary Glands in Isolated Rapid Eye Movement Sleep Behavior Disorder and Parkinson's Disease.Genes, , Sep-24, Volume: 13, Issue:10, 2022
Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies.Brain : a journal of neurology, , 04-18, Volume: 145, Issue:2, 2022
Gray Matter Volume Loss in Proposed Brain-First and Body-First Parkinson's Disease Subtypes.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:10, 2022
Recent advances in establishing fluid biomarkers for the diagnosis and differentiation of alpha-synucleinopathies - a mini review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 32, Issue:4, 2022
Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study.The Lancet. Neurology, , Volume: 20, Issue:3, 2021
Immunohistochemical Detection of Synuclein Pathology in Skin in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:4, 2021
REM sleep behavior disorder and other sleep abnormalities in p. A53T SNCA mutation carriers.Sleep, , 05-14, Volume: 44, Issue:5, 2021
Asymmetric Dopaminergic Dysfunction in Brain-First versus Body-First Parkinson's Disease Subtypes.Journal of Parkinson's disease, , Volume: 11, Issue:4, 2021
Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder.The Lancet. Neurology, , Volume: 20, Issue:8, 2021
Brainstem Quadruple Aberrant Hyperphosphorylated Tau, Beta-Amyloid, Alpha-Synuclein and TDP-43 Pathology, Stress and Sleep Behavior Disorders.International journal of environmental research and public health, , 06-22, Volume: 18, Issue:13, 2021
Cutaneous α-synuclein is correlated with autonomic impairment in isolated rapid eye movement sleep behavior disorder.Sleep, , 12-10, Volume: 44, Issue:12, 2021
Consistent skin α-synuclein positivity in REM sleep behavior disorder - A two center two-to-four-year follow-up study.Parkinsonism & related disorders, , Volume: 86, 2021
Hypomethylation of SNCA in Idiopathic REM Sleep Behavior Disorder Associated With Phenoconversion.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:4, 2021
Increased Accumulation of α-Synuclein in Inflamed Appendices of Parkinson's Disease Patients.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:8, 2021
Alpha-synuclein seeds in olfactory mucosa of patients with isolated REM sleep behaviour disorder.Brain : a journal of neurology, , 05-07, Volume: 144, Issue:4, 2021
Fine-Mapping of SNCA in Rapid Eye Movement Sleep Behavior Disorder and Overt Synucleinopathies.Annals of neurology, , Volume: 87, Issue:4, 2020
[REM Sleep Behavior Disorder and α-synucleinopathy].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:2, 2020
The role of tissue biopsy as a biomarker in REM sleep behavior disorder.Sleep medicine reviews, , Volume: 51, 2020
SNCA Hypomethylation in Rapid Eye Movement Sleep Behavior Disorder Is a Potential Biomarker for Parkinson's Disease.Journal of Parkinson's disease, , Volume: 10, Issue:3, 2020
Propagated α-synucleinopathy recapitulates REM sleep behaviour disorder followed by parkinsonian phenotypes in mice.Brain : a journal of neurology, , 12-05, Volume: 143, Issue:11, 2020
Impaired metabolic brain networks associated with neurotransmission systems in the α-synuclein spectrum.Parkinsonism & related disorders, , Volume: 81, 2020
α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson's disease model.Brain : a journal of neurology, , 01-01, Volume: 143, Issue:1, 2020
Longitudinal analyses of cerebrospinal fluid α-Synuclein in prodromal and early Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:9, 2019
Simultaneous tonic and phasic REM sleep without atonia best predicts early phenoconversion to neurodegenerative disease in idiopathic REM sleep behavior disorder.Sleep, , 09-06, Volume: 42, Issue:9, 2019
CSF Biomarkers for Early Diagnosis of Synucleinopathies: Focus on Idiopathic RBD.Current neurology and neuroscience reports, , 01-14, Volume: 19, Issue:2, 2019
Abnormal α-synuclein deposits in skin nerves: intra- and inter-laboratory reproducibility.European journal of neurology, , Volume: 26, Issue:10, 2019
Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients.Annals of clinical and translational neurology, , Volume: 6, Issue:9, 2019
Precision Medicine in Rapid Eye Movement Sleep Behavior Disorder.Sleep medicine clinics, , Volume: 14, Issue:3, 2019
[Differential diagnosis of RBD symptomatology (idiopathic RBD or RBD mimics)].Rinsho shinkeigaku = Clinical neurology, , Apr-25, Volume: 59, Issue:4, 2019
[A case of severe obstructive sleep apnea mimicking REM sleep behavior disorder].Rinsho shinkeigaku = Clinical neurology, , Apr-25, Volume: 59, Issue:4, 2019
Rapid eye movement sleep behavior disorder and the link to alpha-synucleinopathies.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, , Volume: 129, Issue:8, 2018
Deterioration of executive dysfunction in elderly with REM sleep behavior disorder (RBD).Neurobiology of aging, , Volume: 70, 2018
The "when" and "where" of α-synucleinopathies: Insights from REM sleep behavior disorder.Neurology, , 09-04, Volume: 91, Issue:10, 2018
Predicting alpha-synuclein pathology by REM sleep behavior disorder diagnosis.Parkinsonism & related disorders, , Volume: 55, 2018
REM behavior disorder predicts motor progression and cognitive decline in Parkinson disease.Neurology, , 09-04, Volume: 91, Issue:10, 2018
Idiopathic REM sleep behaviour disorder and neurodegeneration - an update.Nature reviews. Neurology, , Volume: 14, Issue:1, 2018
Risk variants of the α-synuclein locus and REM sleep behavior disorder in Parkinson's disease: a genetic association study.BMC neurology, , Feb-21, Volume: 18, Issue:1, 2018
REM sleep behaviour disorder.Nature reviews. Disease primers, , 08-30, Volume: 4, Issue:1, 2018
α-Synuclein aggregates in labial salivary glands of idiopathic rapid eye movement sleep behavior disorder.Sleep, , 08-01, Volume: 41, Issue:8, 2018
Alpha-synuclein aggregates in the parotid gland of idiopathic REM sleep behavior disorder.Sleep medicine, , Volume: 52, 2018
Diagnostic biomarkers for Parkinson's disease at a glance: where are we?Journal of neural transmission (Vienna, Austria : 1996), , Volume: 125, Issue:10, 2018
Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.Disease models & mechanisms, , 05-01, Volume: 10, Issue:5, 2017
REM sleep behavior disorder is related to enteric neuropathology in Parkinson disease.Neurology, , Oct-10, Volume: 89, Issue:15, 2017
Dermal phospho-alpha-synuclein deposits confirm REM sleep behaviour disorder as prodromal Parkinson's disease.Acta neuropathologica, , Volume: 133, Issue:4, 2017
Skin nerve phosphorylated α-synuclein deposits in idiopathic REM sleep behavior disorder.Neurology, , May-30, Volume: 88, Issue:22, 2017
SNCA 3'UTR genetic variants in patients with Parkinson's disease and REM sleep behavior disorder.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 38, Issue:7, 2017
Diagnosis, disease notification, and management of rapid eye movement (REM) sleep behavior disorder.Rinsho shinkeigaku = Clinical neurology, , 02-25, Volume: 57, Issue:2, 2017
Assessment of α-synuclein in submandibular glands of patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study.The Lancet. Neurology, , Volume: 15, Issue:7, 2016
Brain Atrophy of Secondary REM-Sleep Behavior Disorder in Neurodegenerative Disease.Journal of Alzheimer's disease : JAD, , 04-05, Volume: 52, Issue:3, 2016
Parkinson disease: Peripheral α-synuclein deposits - prodromal markers for Parkinson disease?Nature reviews. Neurology, , Volume: 12, Issue:5, 2016
REM sleep behavior disorder and neuropathology in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:10, 2015
Parkinson disease with REM sleep behavior disorder: features, α-synuclein, and inflammation.Neurology, , Mar-03, Volume: 84, Issue:9, 2015
Does REM sleep behavior disorder have the guts to be Parkinson disease?Neurology, , Nov-17, Volume: 85, Issue:20, 2015
Enteric nervous system α-synuclein immunoreactivity in idiopathic REM sleep behavior disorder.Neurology, , Nov-17, Volume: 85, Issue:20, 2015
[REM sleep behavior disorder as a prodromal stage of α-synucleinopathies: symptoms, epidemiology, pathophysiology, diagnosis and therapy].Der Nervenarzt, , Volume: 85, Issue:1, 2014
Dysfunction of the locus coeruleus-norepinephrine system and related circuitry in Parkinson's disease-related dementia.Journal of neurology, neurosurgery, and psychiatry, , Volume: 84, Issue:7, 2013
MRI and pathology of REM sleep behavior disorder in dementia with Lewy bodies.Neurology, , Nov-05, Volume: 81, Issue:19, 2013
Clinical markers of early nigrostriatal neurodegeneration in idiopathic rapid eye movement sleep behavior disorder.Sleep medicine, , Volume: 14, Issue:11, 2013
Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study.The Lancet. Neurology, , Volume: 12, Issue:5, 2013
Neuropathological analysis of brainstem cholinergic and catecholaminergic nuclei in relation to rapid eye movement (REM) sleep behaviour disorder.Neuropathology and applied neurobiology, , Volume: 38, Issue:2, 2012
α-Synuclein and anti-α-synuclein antibodies in Parkinson's disease, atypical Parkinson syndromes, REM sleep behavior disorder, and healthy controls.PloS one, , Volume: 7, Issue:12, 2012
Regional cerebral blood flow changes in patients with idiopathic REM sleep behavior disorder.European journal of neurology, , Volume: 18, Issue:5, 2011
Hallucinations and REM sleep behaviour disorder in Parkinson's disease: dream imagery intrusions and other hypotheses.Consciousness and cognition, , Volume: 20, Issue:4, 2011
REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century.Neurology, , Aug-10, Volume: 75, Issue:6, 2010
[Pathophysiological process underlying Parkinson's disease: motor & non-motor symptoms].Rinsho shinkeigaku = Clinical neurology, , Volume: 49, Issue:11, 2009
Neuropathology of non-motor features of Parkinson disease.Parkinsonism & related disorders, , Volume: 15 Suppl 3, 2009
[Sleep behavior disorder (RBD) in synucleionopaties].Glas. Srpska akademija nauka i umetnosti. Odeljenje medicinskih nauka, , Issue:50, 2009
Expanding the clinical phenotype of SNCA duplication carriers.Movement disorders : official journal of the Movement Disorder Society, , Sep-15, Volume: 24, Issue:12, 2009
Autonomic dysfunction in RBD--what can it teach us about disease progression?Sleep medicine, , Volume: 9, Issue:5, 2008
Validation of the neuropathologic criteria of the third consortium for dementia with Lewy bodies for prospectively diagnosed cases.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:7, 2008
Classical Parkinson disease versus Parkinson complex--reflections against staging and in favour of heterogeneity.European journal of neurology, , Volume: 14, Issue:7, 2007
A 75-year-old man with cognitive impairment and gait changes.Neurology, , Sep-11, Volume: 69, Issue:11, 2007
REM sleep behavior disorder: a possible early marker for synucleinopathies.Neurology, , Mar-28, Volume: 66, Issue:6, 2006
REM sleep behavior disorder: a possible early marker for synucleinopathies.Neurology, , Dec-12, Volume: 67, Issue:11, 2006
Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium.Neurology, , Dec-27, Volume: 65, Issue:12, 2005
Idiopathic REM sleep behavior disorder: toward a better nosologic definition.Neurology, , Mar-08, Volume: 64, Issue:5, 2005
Abnormal sleep architecture is an early feature in the E46K familial synucleinopathy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20, Issue:10, 2005
Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism.Neurology, , Jul-08, Volume: 61, Issue:1, 2003
Alpha-synuclein/synapsin III pathological interplay boosts the motor response to methylphenidate.Neurobiology of disease, , Volume: 138, 2020
Chronic Mild Gut Inflammation Accelerates Brain Neuropathology and Motor Dysfunction in α-Synuclein Mutant Mice.Neuromolecular medicine, , Volume: 21, Issue:3, 2019
CSF β-amyloidNeurology, , 01-01, Volume: 92, Issue:1, 2019
Dynamic footprint based locomotion sway assessment in α-synucleinopathic mice using Fast Fourier Transform and Low Pass Filter.Journal of neuroscience methods, , 02-15, Volume: 296, 2018
Exacerbation of sensorimotor dysfunction in mice deficient in Atp13a2 and overexpressing human wildtype alpha-synuclein.Behavioural brain research, , 05-02, Volume: 343, 2018
Deferiprone Rescues Behavioral Deficits Induced by Mild Iron Exposure in a Mouse Model of Alpha-Synuclein Aggregation.Neuromolecular medicine, , Volume: 19, Issue:2-3, 2017
The novel adaptive rotating beam test unmasks sensorimotor impairments in a transgenic mouse model of Parkinson's disease.Behavioural brain research, , May-01, Volume: 304, 2016
Neuroprotection by Epigenetic Modulation in a Transgenic Model of Multiple System Atrophy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 13, Issue:4, 2016
Electroacupuncture remediates glial dysfunction and ameliorates neurodegeneration in the astrocytic α-synuclein mutant mouse model.Journal of neuroinflammation, , May-28, Volume: 12, 2015
Panax ginseng is neuroprotective in a novel progressive model of Parkinson's disease.Experimental gerontology, , Volume: 50, 2014
Using gastrocnemius sEMG and plasma α-synuclein for the prediction of freezing of gait in Parkinson's disease patients.PloS one, , Volume: 9, Issue:2, 2014
Differentiation of progressive supranuclear palsy: clinical, imaging and laboratory tools.Acta neurologica Scandinavica, , Volume: 127, Issue:5, 2013
Primary progressive aphasia with parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:6, 2013
Schizophrenia-like features in transgenic mice overexpressing human HO-1 in the astrocytic compartment.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Aug-08, Volume: 32, Issue:32, 2012
Cerebellar-type multiple system atrophy presenting with leucoencephalopathy.Journal of neurology, neurosurgery, and psychiatry, , Volume: 83, Issue:2, 2012
Effect of L-ascorbic Acid on the climbing ability and protein levels in the brain of Drosophila model of Parkinson's disease.The International journal of neuroscience, , Volume: 122, Issue:12, 2012
Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 22, Issue:1, 2012
Nitrated alpha-synuclein induces the loss of dopaminergic neurons in the substantia nigra of rats.PloS one, , Apr-08, Volume: 5, Issue:4, 2010
Pure akinesia with gait freezing: a third clinical phenotype of progressive supranuclear palsy.Movement disorders : official journal of the Movement Disorder Society, , Nov-15, Volume: 22, Issue:15, 2007
A 75-year-old man with cognitive impairment and gait changes.Neurology, , Sep-11, Volume: 69, Issue:11, 2007
Ischemic stroke causes Parkinson's disease-like pathology and symptoms in transgenic mice overexpressing alpha-synuclein.Acta neuropathologica communications, , 02-24, Volume: 10, Issue:1, 2022
Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 41, Issue:5, 2021
Impact of Age and Sex on α-Syn (α-Synuclein) Knockdown-Mediated Poststroke Recovery.Stroke, , Volume: 51, Issue:10, 2020
Neuroprotective Effect of Dichloromethane Extraction From Piper nigrum L. and Piper longum L. on Permanent Focal Cerebral Ischemia Injury in Rats.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, , Volume: 28, Issue:3, 2019
Opposing effects of β-2 and β-1 adrenergic receptor signaling on neuroinflammation and dopaminergic neuron survival in α-synuclein-mediated neurotoxicity.Journal of neuroinflammation, , Mar-02, Volume: 20, Issue:1, 2023
Syringin Prevents 6-Hydroxydopamine Neurotoxicity by Mediating the MiR-34a/SIRT1/Beclin-1 Pathway and Activating Autophagy in SH-SY5Y Cells and the Cells, , 09-19, Volume: 12, Issue:18, 2023
[no title available]Oxidative medicine and cellular longevity, , Volume: 2023, 2023
CRISPR-Cas9-Edited SNCA Knockout Human Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons and Their Vulnerability to Neurotoxicity.Biological & pharmaceutical bulletin, , Volume: 46, Issue:3, 2023
APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer's disease with Lewy body pathology.Acta neuropathologica, , Volume: 143, Issue:6, 2022
Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson's Disease.International journal of molecular sciences, , Sep-16, Volume: 23, Issue:18, 2022
Exposure to the environmentally toxic pesticide maneb induces Parkinson's disease-like neurotoxicity in mice: A combined proteomic and metabolomic analysis.Chemosphere, , Volume: 308, Issue:Pt 2, 2022
Distinct neurotoxic TDP-43 fibril polymorphs are generated by heterotypic interactions with α-Synuclein.The Journal of biological chemistry, , Volume: 298, Issue:11, 2022
Paraquat exposure induces Parkinsonism by altering lipid profile and evoking neuroinflammation in the midbrain.Environment international, , Volume: 169, 2022
Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation.Cells, , 11-18, Volume: 11, Issue:22, 2022
The influence of preconditioning with low dose of LPS on paraquat-induced neurotoxicity, microglia activation and expression of α-synuclein and synphilin-1 in the dopaminergic system.Pharmacological reports : PR, , Volume: 74, Issue:1, 2022
6-Hydroxydopamine-Induced Neurotoxicity in Rat Model of Parkinson's Disease: Is Reversed via Anti-Oxidative Activities of Curcumin and Aerobic Exercise Therapy.Physiological research, , Aug-31, Volume: 71, Issue:4, 2022
Methanolic Extract of Boswellia serrata Gum Protects the Nigral Dopaminergic Neurons from Rotenone-Induced Neurotoxicity.Molecular neurobiology, , Volume: 59, Issue:9, 2022
Transfer of neuron-derived α-synuclein to astrocytes induces neuroinflammation and blood-brain barrier damage after methamphetamine exposure: Involving the regulation of nuclear receptor-associated protein 1.Brain, behavior, and immunity, , Volume: 106, 2022
The food additive fast green FCF inhibits α-synuclein aggregation, disassembles mature fibrils and protects against amyloid-induced neurotoxicity.Food & function, , Jun-21, Volume: 12, Issue:12, 2021
LncRNA OIP5-AS1 reduces α-synuclein aggregation and toxicity by targeting miR-126 to activate PLK2 in human neuroblastoma SH-SY5Y cells.Neuroscience letters, , 01-01, Volume: 740, 2021
Kaempferol Has Potent Protective and Antifibrillogenic Effects for α-Synuclein Neurotoxicity In Vitro.International journal of molecular sciences, , Oct-25, Volume: 22, Issue:21, 2021
The Role of α-Synuclein in Methamphetamine-Induced Neurotoxicity.Neurotoxicity research, , Volume: 39, Issue:3, 2021
The effect of α-synuclein and Tau in methamphetamine induced neurotoxicity in vivo and in vitro.Toxicology letters, , Feb-01, Volume: 319, 2020
Alpha-Synuclein deficiency ameliorates chronic methamphetamine induced neurodegeneration in mice.Toxicology, , 05-30, Volume: 438, 2020
Transfer of pathological α-synuclein from neurons to astrocytes via exosomes causes inflammatory responses after METH exposure.Toxicology letters, , Oct-01, Volume: 331, 2020
Role of alpha-synuclein phosphorylation at Serine 129 in methamphetamine-induced neurotoxicity in vitro and in vivo.Neuroreport, , 08-05, Volume: 31, Issue:11, 2020
The role of chaperone-mediated autophagy in neurotoxicity induced by alpha-synuclein after methamphetamine exposure.Brain and behavior, , Volume: 9, Issue:8, 2019
Effect of methamphetamine on rat primary midbrain cells; mitochondrial biogenesis as a compensatory response.Neuroscience, , 05-15, Volume: 406, 2019
FLZ Attenuates α-Synuclein-Induced Neurotoxicity by Activating Heat Shock Protein 70.Molecular neurobiology, , Volume: 54, Issue:1, 2017
In vitro neurotoxic hazard characterisation of dinitrophenolic herbicides.Toxicology letters, , Jun-11, Volume: 252, 2016
The neural chaperone proSAAS blocks α-synuclein fibrillation and neurotoxicity.Proceedings of the National Academy of Sciences of the United States of America, , 08-09, Volume: 113, Issue:32, 2016
Role of autophagy in arsenite-induced neurotoxicity: the involvement of α-synuclein.Toxicology letters, , Mar-18, Volume: 233, Issue:3, 2015
Drugs That Bind to α-Synuclein: Neuroprotective or Neurotoxic?ACS chemical neuroscience, , Dec-16, Volume: 6, Issue:12, 2015
Definition of a molecular pathway mediating α-synuclein neurotoxicity.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Apr-01, Volume: 35, Issue:13, 2015
S-Nitrosylating protein disulphide isomerase mediates α-synuclein aggregation caused by methamphetamine exposure in PC12 cells.Toxicology letters, , Oct-01, Volume: 230, Issue:1, 2014
Brain injection of α-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Sep-10, Volume: 34, Issue:37, 2014
The nuclear accumulation of alpha-synuclein is mediated by importin alpha and promotes neurotoxicity by accelerating the cell cycle.Neuropharmacology, , Volume: 82, 2014
Roles of autophagy in MPP+-induced neurotoxicity in vivo: the involvement of mitochondria and α-synuclein aggregation.PloS one, , Volume: 9, Issue:3, 2014
Commentary: Progressive inflammation as a contributing factor to early development of Parkinson's disease.Experimental neurology, , Volume: 241, 2013
A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 9, Issue:2, 2012
A proteomic analysis of MCLR-induced neurotoxicity: implications for Alzheimer's disease.Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 127, Issue:2, 2012
Synphilin suppresses α-synuclein neurotoxicity in a Parkinson's disease Drosophila model.Genesis (New York, N.Y. : 2000), , Volume: 49, Issue:5, 2011
Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation.PloS one, , Jan-31, Volume: 6, Issue:1, 2011
Cold water stress attenuates dopaminergic neurotoxicity induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.Acta biochimica et biophysica Sinica, , Volume: 43, Issue:6, 2011
Endoplasmic reticulum stress is involved in arsenite-induced oxidative injury in rat brain.Toxicology and applied pharmacology, , Oct-15, Volume: 224, Issue:2, 2007
Behavioral and histopathological consequences of paraquat intoxication in mice: effects of alpha-synuclein over-expression.Synapse (New York, N.Y.), , Volume: 61, Issue:12, 2007
Effects of the cholesterol-lowering compound methyl-beta-cyclodextrin in models of alpha-synucleinopathy.Journal of neurochemistry, , Volume: 98, Issue:4, 2006
Mesenchymal stem-cell-derived microvesicles ameliorate MPTP-induced neurotoxicity in mice: a role of the gut-microbiota-brain axis.Psychopharmacology, , Volume: 240, Issue:5, 2023
Novel FABP3 ligand, HY-11-9, ameliorates neuropathological deficits in MPTP-induced Parkinsonism in mice.Journal of pharmacological sciences, , Volume: 152, Issue:1, 2023
Apoptotic Factors and Mitochondrial Complexes Assist Determination of Strain-Specific Susceptibility of Mice to Parkinsonian Neurotoxin MPTP.Molecular neurobiology, , Volume: 60, Issue:8, 2023
Gastric Enteric Glial Cells: A New Contributor to the Synucleinopathies in the MPTP-Induced Parkinsonism Mouse.Molecules (Basel, Switzerland), , Nov-01, Volume: 27, Issue:21, 2022
Fas-associated factor 1 induces the accumulation of α-synuclein through autophagic suppression in dopaminergic neurons.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 35, Issue:4, 2021
α-synuclein abnormalities trigger focal tau pathology, spreading to various brain areas in Parkinson disease.Journal of neurochemistry, , Volume: 157, Issue:3, 2021
Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models.Communications biology, , 02-19, Volume: 4, Issue:1, 2021
[no title available]International journal of molecular sciences, , Aug-29, Volume: 22, Issue:17, 2021
Potential therapeutic role of fibroblast growth factor 21 in neurodegeneration: Evidence for ameliorating parkinsonism via silent information regulator 2 homolog 1 and implication for gene therapy.Neuropharmacology, , 12-15, Volume: 181, 2020
Papaverine inhibits α-synuclein aggregation by modulating neuroinflammation and matrix metalloproteinase-3 expression in the subacute MPTP/P mouse model of Parkinson's disease.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 130, 2020
Silymarin Protects Against Impaired Autophagy Associated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinsonism.Journal of molecular neuroscience : MN, , Volume: 70, Issue:2, 2020
Neuroprotective effects of Astilbin on MPTP-induced Parkinson's disease mice: Glial reaction, α-synuclein expression and oxidative stress.International immunopharmacology, , Volume: 66, 2019
Inhibition of MPTP-induced α-synuclein oligomerization by fatty acid-binding protein 3 ligand in MPTP-treated mice.Neuropharmacology, , 05-15, Volume: 150, 2019
Ginsenoside Rb1 prevents MPTP-induced changes in hippocampal memory via regulation of the α-synuclein/PSD-95 pathway.Aging, , 04-04, Volume: 11, Issue:7, 2019
Cardiac sympathetic innervation in the MPTP non-human primate model of Parkinson disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 29, Issue:4, 2019
Neuroprotective effects of lithium on a chronic MPTP mouse model of Parkinson's disease via regulation of α‑synuclein methylation.Molecular medicine reports, , Volume: 19, Issue:6, 2019
Total glucosides of paeony (TGP) extracted from Radix Paeoniae Alba exerts neuroprotective effects in MPTP-induced experimental parkinsonism by regulating the cAMP/PKA/CREB signaling pathway.Journal of ethnopharmacology, , Dec-05, Volume: 245, 2019
Semaglutide is Neuroprotective and Reduces α-Synuclein Levels in the Chronic MPTP Mouse Model of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 9, Issue:1, 2019
Impairment of Nrf2- and Nitrergic-Mediated Gastrointestinal Motility in an MPTP Mouse Model of Parkinson's Disease.Digestive diseases and sciences, , Volume: 64, Issue:12, 2019
Rosmarinic acid protects against MPTP-induced toxicity and inhibits iron-induced α-synuclein aggregation.Neuropharmacology, , Volume: 144, 2019
Cardiolipin remodeling by ALCAT1 links mitochondrial dysfunction to Parkinson's diseases.Aging cell, , Volume: 18, Issue:3, 2019
α-Synuclein disrupts the anti-inflammatory role of Drd2 via interfering β-arrestin2-TAB1 interaction in astrocytes.Journal of neuroinflammation, , Sep-10, Volume: 15, Issue:1, 2018
Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 06-19, Volume: 115, Issue:25, 2018
Decreased expression of serum- and glucocorticoid-inducible kinase 1 (SGK1) promotes alpha-synuclein increase related with down-regulation of dopaminergic cell in the Substantia Nigra of chronic MPTP-induced Parkinsonism mice and in SH-SY5Y cells.Gene, , Jun-30, Volume: 661, 2018
The Potential Role of Toll-Like Receptor 4 in Mediating Dopaminergic Cell Loss and Alpha-Synuclein Expression in the Acute MPTP Mouse Model of Parkinson's Disease.Journal of molecular neuroscience : MN, , Volume: 64, Issue:4, 2018
Fingolimod (FTY720) is not protective in the subacute MPTP mouse model of Parkinson's disease and does not lead to a sustainable increase of brain-derived neurotrophic factor.Journal of neurochemistry, , Volume: 147, Issue:5, 2018
NLRP3 inflammasome activation in the thymus of MPTP-induced Parkinsonian mouse model.Toxicology letters, , May-15, Volume: 288, 2018
Soluble Epoxide Hydrolase Inhibition Attenuates MPTP-Induced Neurotoxicity in the Nigrostriatal Dopaminergic System: Involvement of α-Synuclein Aggregation and ER Stress.Molecular neurobiology, , Volume: 55, Issue:1, 2018
Immunization with α-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic Parkinsonism model.Glia, , Volume: 66, Issue:1, 2018
Phosphorylated α-Synuclein Accumulations and Lewy Body-like Pathology Distributed in Parkinson's Disease-Related Brain Areas of Aged Rhesus Monkeys Treated with MPTP.Neuroscience, , 05-21, Volume: 379, 2018
Treadmill Exercise Attenuates α-Synuclein Levels by Promoting Mitochondrial Function and Autophagy Possibly via SIRT1 in the Chronic MPTP/P-Induced Mouse Model of Parkinson's Disease.Neurotoxicity research, , Volume: 32, Issue:3, 2017
α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation.Proceedings of the National Academy of Sciences of the United States of America, , 01-31, Volume: 114, Issue:5, 2017
Treadmill exercise alleviates motor deficits and improves mitochondrial import machinery in an MPTP-induced mouse model of Parkinson's disease.Experimental gerontology, , Volume: 89, 2017
Metformin lowers α-synuclein phosphorylation and upregulates neurotrophic factor in the MPTP mouse model of Parkinson's disease.Neuropharmacology, , Volume: 125, 2017
A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity.Autophagy, , Jul-03, Volume: 13, Issue:7, 2017
Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson's disease.Experimental neurology, , Volume: 295, 2017
Neuroprotective effects of endurance exercise against neuroinflammation in MPTP-induced Parkinson's disease mice.Brain research, , 01-15, Volume: 1655, 2017
7,8-dihydroxyflavone Ameliorates Motor Deficits Via Suppressing α-synuclein Expression and Oxidative Stress in the MPTP-induced Mouse Model of Parkinson's Disease.CNS neuroscience & therapeutics, , Volume: 22, Issue:7, 2016
Influences of Chronic Mild Stress Exposure on Motor, Non-Motor Impairments and Neurochemical Variables in Specific Brain Areas of MPTP/Probenecid Induced Neurotoxicity in Mice.PloS one, , Volume: 11, Issue:1, 2016
Dopaminergic lesioning impairs adult hippocampal neurogenesis by distinct modification of α-synuclein.Journal of neuroscience research, , Volume: 94, Issue:1, 2016
Protective effects and mechanisms of Ndfipl on SH-SY5Y cell apoptosis in an in vitro Parkinson's disease model.Genetics and molecular research : GMR, , Apr-25, Volume: 15, Issue:2, 2016
BAG1 is neuroprotective in in vivo and in vitro models of Parkinson's disease.Journal of molecular neuroscience : MN, , Volume: 55, Issue:3, 2015
Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression.Acta neuropathologica communications, , Jul-25, Volume: 3, 2015
Targeted Overexpression of α-Synuclein by rAAV2/1 Vectors Induces Progressive Nigrostriatal Degeneration and Increases Vulnerability to MPTP in Mouse.PloS one, , Volume: 10, Issue:6, 2015
PAR2-mediated epigenetic upregulation of α-synuclein contributes to the pathogenesis of Parkinson׳s disease.Brain research, , May-27, Volume: 1565, 2014
FABP3 protein promotes α-synuclein oligomerization associated with 1-methyl-1,2,3,6-tetrahydropiridine-induced neurotoxicity.The Journal of biological chemistry, , Jul-04, Volume: 289, Issue:27, 2014
Impairment of the septal cholinergic neurons in MPTP-treated A30P α-synuclein mice.Neurobiology of aging, , Volume: 34, Issue:2, 2013
Geraniol attenuates α-synuclein expression and neuromuscular impairment through increase dopamine content in MPTP intoxicated mice by dose dependent manner.Biochemical and biophysical research communications, , Nov-01, Volume: 440, Issue:4, 2013
Therapeutic effects of rapamycin on MPTP-induced Parkinsonism in mice.Neurochemical research, , Volume: 38, Issue:1, 2013
The neuroprotective effect of fisetin in the MPTP model of Parkinson's disease.Journal of Parkinson's disease, , Volume: 2, Issue:4, 2012
Loss of spinal motor neurons and alteration of alpha-synuclein immunostaining in MPTP induced Parkinsonism in mice.Journal of chemical neuroanatomy, , Volume: 44, Issue:2, 2012
Mitochondrial permeability transition pore component cyclophilin D distinguishes nigrostriatal dopaminergic death paradigms in the MPTP mouse model of Parkinson's disease.Antioxidants & redox signaling, , May-01, Volume: 16, Issue:9, 2012
FLZ protects dopaminergic neuron through activating protein kinase B/mammalian target of rapamycin pathway and inhibiting RTP801 expression in Parkinson's disease models.Neuroscience, , Jan-27, Volume: 202, 2012
Animal models of the non-motor features of Parkinson's disease.Neurobiology of disease, , Volume: 46, Issue:3, 2012
Mutant α-synuclein and aging reduce neurogenesis in the acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.Aging cell, , Volume: 10, Issue:2, 2011
Increased iron levels correlate with the selective nigral dopaminergic neuron degeneration in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 118, Issue:3, 2011
Dopamine-depletion and increased α-synuclein load induce degeneration of cortical cholinergic fibers in mice.Journal of the neurological sciences, , Nov-15, Volume: 310, Issue:1-2, 2011
Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation.PloS one, , Jan-31, Volume: 6, Issue:1, 2011
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Analysis of circulating metabolites to differentiate Parkinson's disease and essential tremor.Neuroscience letters, , 01-19, Volume: 769, 2022
Characterizing Lewy Pathology in 231 Essential Tremor Brains From the Essential Tremor Centralized Brain Repository.Journal of neuropathology and experimental neurology, , 09-19, Volume: 81, Issue:10, 2022
The roles of HSP40/DNAJ protein family in neurodegenerative diseases.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, , Nov-25, Volume: 51, Issue:5, 2022
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Analysis of the coding and the 5' flanking regions of the alpha-synuclein gene in patients with Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 16, Issue:6, 2001
Propofol Attenuates α-Synuclein Aggregation and Neuronal Damage in a Mouse Model of Ischemic Stroke.Neuroscience bulletin, , Volume: 36, Issue:3, 2020
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Tau and GSK-3β are Critical Contributors to α-Synuclein-Mediated Post-Stroke Brain Damage.Neuromolecular medicine, , Volume: 25, Issue:1, 2023
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How gut microbes could drive brain disorders.Nature, , Volume: 590, Issue:7844, 2021
Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 41, Issue:5, 2021
Propofol Attenuates α-Synuclein Aggregation and Neuronal Damage in a Mouse Model of Ischemic Stroke.Neuroscience bulletin, , Volume: 36, Issue:3, 2020
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Visual discrimination impairment after experimental stroke is associated with disturbances in the polarization of the astrocytic aquaporin-4 and increased accumulation of neurotoxic proteins.Experimental neurology, , Volume: 318, 2019
The microRNA miR-7a-5p ameliorates ischemic brain damage by repressing α-synuclein.Science signaling, , 12-11, Volume: 11, Issue:560, 2018
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A comparative study of the amount of α-synuclein in ischemic stroke and Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 37, Issue:5, 2016
Na(+)-K (+)-2Cl (-) cotransport inhibitor attenuates cerebral edema following experimental stroke via the perivascular pool of aquaporin-4.Neurocritical care, , Volume: 13, Issue:1, 2010
Role of Oligodendrocyte Lineage Cells in Multiple System Atrophy.Cells, , 02-25, Volume: 12, Issue:5, 2023
Novel FABP3 ligand, HY-11-9, ameliorates neuropathological deficits in MPTP-induced Parkinsonism in mice.Journal of pharmacological sciences, , Volume: 152, Issue:1, 2023
Evaluation of α-synuclein in CNS-originating extracellular vesicles for Parkinsonian disorders: A systematic review and meta-analysis.CNS neuroscience & therapeutics, , Volume: 29, Issue:12, 2023
Seed amplification assay results illustrate discrepancy in Parkinson's disease clinical diagnostic accuracy and error rates.Journal of neurology, , Volume: 270, Issue:12, 2023
Oligomeric α-synuclein and tau aggregates in NDEVs differentiate Parkinson's disease from atypical parkinsonisms.Neurobiology of disease, , Volume: 176, 2023
Interlinked role of ASN, TDP-43 and Miro1 with parkinopathy: Focus on targeted approach against neuropathy in parkinsonism.Ageing research reviews, , Volume: 83, 2023
Blood-Based α-Synuclein Seeding-A New Era for Identifying Parkinsonian Syndromes.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:8, 2023
Impaired aldehyde detoxification exacerbates motor deficits in an alpha-synuclein mouse model of Parkinson's disease.Brain and behavior, , Volume: 13, Issue:9, 2023
Hippocampal synaptic failure is an early event in experimental parkinsonism with subtle cognitive deficit.Brain : a journal of neurology, , Dec-01, Volume: 146, Issue:12, 2023
The unexpected finding of CNS autoantibodies in GBA1 mutation carriers with atypical parkinsonism.Journal of neuropathology and experimental neurology, , 08-21, Volume: 82, Issue:9, 2023
Neuroprotective effects of isatin and afobazole in rats with rotenone-induced Parkinsonism are accompanied by increased brain levels of Triton X-100 soluble alpha-synuclein.Biomeditsinskaia khimiia, , Volume: 69, Issue:5, 2023
Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions.Proceedings of the National Academy of Sciences of the United States of America, , 03-28, Volume: 120, Issue:13, 2023
Translational molecular imaging and drug development in Parkinson's disease.Molecular neurodegeneration, , 02-10, Volume: 18, Issue:1, 2023
Non-Reproducibility of Oral Rotenone as a Model for Parkinson's Disease in Mice.International journal of molecular sciences, , Oct-21, Volume: 23, Issue:20, 2022
Glutathione Depletion and MicroRNA Dysregulation in Multiple System Atrophy: A Review.International journal of molecular sciences, , Dec-01, Volume: 23, Issue:23, 2022
Gastric Enteric Glial Cells: A New Contributor to the Synucleinopathies in the MPTP-Induced Parkinsonism Mouse.Molecules (Basel, Switzerland), , Nov-01, Volume: 27, Issue:21, 2022
Combined CSF α-SYN RT-QuIC, CSF NFL and midbrain-pons planimetry in degenerative parkinsonisms: From bedside to bench, and back again.Parkinsonism & related disorders, , Volume: 99, 2022
Phosphorylated α-Synuclein Deposits in Cutaneous Nerves of Early Parkinsonism.Journal of Parkinson's disease, , Volume: 12, Issue:8, 2022
Alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy.Translational neurodegeneration, , 02-07, Volume: 11, Issue:1, 2022
Lippia grata essential oil complexed with β-cyclodextrin ameliorates biochemical and behavioral deficits in an animal model of progressive parkinsonism.Metabolic brain disease, , Volume: 37, Issue:7, 2022
Striatal synaptic bioenergetic and autophagic decline in premotor experimental parkinsonism.Brain : a journal of neurology, , 06-30, Volume: 145, Issue:6, 2022
Sesquiterpenoids isolated from davana (Artemisia pallens Wall. ex DC) mitigates parkinsonism in Caenorhabditis elegans disease model.Biochemical and biophysical research communications, , 06-18, Volume: 609, 2022
Presence of Skin α-Synuclein Deposits Discriminates Parkinson's Disease from Progressive Supranuclear Palsy and Corticobasal Syndrome.Journal of Parkinson's disease, , Volume: 12, Issue:2, 2022
Long-standing multiple system atrophy-Parkinsonism with limbic and FTLD-type α-synuclein pathology.Neuropathology and applied neurobiology, , Volume: 48, Issue:3, 2022
Immunisation with UB-312 in the Thy1SNCA mouse prevents motor performance deficits and oligomeric α-synuclein accumulation in the brain and gut.Acta neuropathologica, , Volume: 143, Issue:1, 2022
Paraquat exposure induces Parkinsonism by altering lipid profile and evoking neuroinflammation in the midbrain.Environment international, , Volume: 169, 2022
Post-COVID-19 Parkinsonism and Parkinson's Disease Pathogenesis: The Exosomal Cargo Hypothesis.International journal of molecular sciences, , Aug-28, Volume: 23, Issue:17, 2022
GDNF signaling in subjects with minimal motor deficits and Parkinson's disease.Neurobiology of disease, , Volume: 153, 2021
Validation of α-Synuclein in L1CAM-Immunocaptured Exosomes as a Biomarker for the Stratification of Parkinsonian Syndromes.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:11, 2021
HDAC6-mediated Hsp90 deacetylation reduces aggregation and toxicity of the protein alpha-synuclein by regulating chaperone-mediated autophagy.Neurochemistry international, , Volume: 149, 2021
Diterpene glycosides from Holothuria scabra exert the α-synuclein degradation and neuroprotection against α-synuclein-Mediated neurodegeneration in C. elegans model.Journal of ethnopharmacology, , Oct-28, Volume: 279, 2021
PHB blocks endoplasmic reticulum stress and apoptosis induced by MPTP/MPPJournal of chemical neuroanatomy, , Volume: 113, 2021
Fecal Microbiota Transplantation Exerts a Protective Role in MPTP-Induced Parkinson's Disease via the TLR4/PI3K/AKT/NF-κB Pathway Stimulated by α-Synuclein.Neurochemical research, , Volume: 46, Issue:11, 2021
Mechanisms of Neurodegeneration in Various Forms of Parkinsonism-Similarities and Differences.Cells, , 03-16, Volume: 10, Issue:3, 2021
Dose-related biphasic effect of the Parkinson's disease neurotoxin MPTP, on the spread, accumulation, and toxicity of α-synuclein.Neurotoxicology, , Volume: 84, 2021
Toxic Feedback Loop Involving Iron, Reactive Oxygen Species, α-Synuclein and Neuromelanin in Parkinson's Disease and Intervention with Turmeric.Molecular neurobiology, , Volume: 58, Issue:11, 2021
Mechanistic insights into the protective effect of paracetamol against rotenone-induced Parkinson's disease in rats: Possible role of endocannabinoid system modulation.International immunopharmacology, , Volume: 94, 2021
Oral Administration of Silibinin Ameliorates Cognitive Deficits of Parkinson's Disease Mouse Model by Restoring Mitochondrial Disorders in Hippocampus.Neurochemical research, , Volume: 46, Issue:9, 2021
Wedelolactone Mitigates Parkinsonism Via Alleviating Oxidative Stress and Mitochondrial Dysfunction Through NRF2/SKN-1.Molecular neurobiology, , Volume: 58, Issue:1, 2021
L-DOPA regulates α-synuclein accumulation in experimental parkinsonism.Neuropathology and applied neurobiology, , Volume: 47, Issue:4, 2021
VPS35 D620N knockin mice recapitulate cardinal features of Parkinson's disease.Aging cell, , Volume: 20, Issue:5, 2021
Memantine exerts neuroprotective effects by modulating α-synuclein transmission in a parkinsonian model.Experimental neurology, , Volume: 344, 2021
Neuroprotection of Exendin-4 by Enhanced Autophagy in a Parkinsonian Rat Model of α-Synucleinopathy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 18, Issue:2, 2021
The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson's disease.Neurobiology of disease, , Volume: 153, 2021
Sgt1 Regulates α-Synuclein Subcellular Localization and Expression of Parkinson's Disease Related Genes, Biomolecules, , 11-11, Volume: 11, Issue:11, 2021
Monoamine Oxidase-B Inhibition Facilitates α-Synuclein Secretion The Journal of neuroscience : the official journal of the Society for Neuroscience, , 09-01, Volume: 41, Issue:35, 2021
Neuroprotective effect of paeoniflorin in the mouse model of Parkinson's disease through α-synuclein/protein kinase C δ subtype signaling pathway.Neuroreport, , 12-08, Volume: 32, Issue:17, 2021
Interaction between coxsackievirus B3 infection and α-synuclein in models of Parkinson's disease.PLoS pathogens, , Volume: 17, Issue:10, 2021
Direct targeting of wild-type glucocerebrosidase by antipsychotic quetiapine improves pathogenic phenotypes in Parkinson's disease models.JCI insight, , 10-08, Volume: 6, Issue:19, 2021
Is Multiple System Atrophy a Prion-like Disorder?International journal of molecular sciences, , Sep-18, Volume: 22, Issue:18, 2021
Reply to: "α-Synuclein (SNCA) A30G Mutation as a Cause of a Complex Phenotype Without Parkinsonism".Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:9, 2021
α-Synuclein (SNCA) A30G Mutation as a Cause of a Complex Phenotype Without Parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:9, 2021
Heterozygous GBA D409V and ATP13a2 mutations do not exacerbate pathological α-synuclein spread in the prodromal preformed fibrils model in young mice.Neurobiology of disease, , Volume: 159, 2021
Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders.Acta neuropathologica, , Volume: 142, Issue:6, 2021
Prodromal sensory neuropathy in Pink1Neuropathology and applied neurobiology, , Volume: 47, Issue:7, 2021
A bibenzyl compound 20C protects rats against 6-OHDA-induced damage by regulating adaptive immunity associated molecules.International immunopharmacology, , Volume: 91, 2021
Failure of Diphtheria Toxin Model to Induce Parkinson-Like Behavior in Mice.International journal of molecular sciences, , Aug-31, Volume: 22, Issue:17, 2021
Nigral overexpression of α-synuclein in a rat Parkinson's disease model indicates alterations in the enteric nervous system and the gut microbiome.Neurogastroenterology and motility, , Volume: 32, Issue:1, 2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disease.International journal of molecular sciences, , Nov-10, Volume: 21, Issue:22, 2020
Systemic activation of Nrf2 pathway in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:1, 2020
Astrocytes Protect Human Dopaminergic Neurons from α-Synuclein Accumulation and Propagation.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 11-04, Volume: 40, Issue:45, 2020
Immunoregulation of microglial polarization: an unrecognized physiological function of α-synuclein.Journal of neuroinflammation, , Sep-17, Volume: 17, Issue:1, 2020
α-Synuclein real-time quaking-induced conversion in the submandibular glands of Parkinson's disease patients.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:2, 2020
Ropinirole silver nanocomposite attenuates neurodegeneration in the transgenic Drosophila melanogaster model of Parkinson's disease.Neuropharmacology, , 10-15, Volume: 177, 2020
Alpha-synuclein oligomerization and dopaminergic degeneration occur synchronously in the brain and colon of MPTP-intoxicated parkinsonian monkeys.Neuroscience letters, , 01-18, Volume: 716, 2020
Limited spread of pathology within the brainstem of α-synuclein BAC transgenic mice inoculated with preformed fibrils into the gastrointestinal tract.Neuroscience letters, , 01-18, Volume: 716, 2020
Neuroprotective function of Omi to α-synuclein-induced neurotoxicity.Neurobiology of disease, , Volume: 136, 2020
Acupuncture Inhibits the Increase in Alpha-Synuclein in Substantia Nigra in an MPTP- Induced Parkinsonism Mouse Model.Advances in experimental medicine and biology, , Volume: 1232, 2020
Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult.Neuron, , 03-04, Volume: 105, Issue:5, 2020
miR-30b protects nigrostriatal dopaminergic neurons from MPP(+)-induced neurotoxicity via SNCA.Brain and behavior, , Volume: 10, Issue:4, 2020
Propagated α-synucleinopathy recapitulates REM sleep behaviour disorder followed by parkinsonian phenotypes in mice.Brain : a journal of neurology, , 12-05, Volume: 143, Issue:11, 2020
Back and to the Future: From Neurotoxin-Induced to Human Parkinson's Disease Models.Current protocols in neuroscience, , Volume: 91, Issue:1, 2020
Beneficial effects of cysteamine in Thy1-α-Syn mice and induced pluripotent stem cells with a SNCA gene triplication.Neurobiology of disease, , Volume: 145, 2020
Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits.Neurobiology of disease, , Volume: 141, 2020
Neuroprotection of Rotenone-Induced Parkinsonism by Ursolic Acid in PD Mouse Model.CNS & neurological disorders drug targets, , Volume: 19, Issue:7, 2020
Emerging Targeted Therapeutics for Genetic Subtypes of Parkinsonism.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 17, Issue:4, 2020
Simple and Complex Sugars in Parkinson's Disease: a Bittersweet Taste.Molecular neurobiology, , Volume: 57, Issue:7, 2020
Alpha-Synuclein Protofibrils in Cerebrospinal Fluid: A Potential Biomarker for Parkinson's Disease.Journal of Parkinson's disease, , Volume: 10, Issue:4, 2020
Open questions on the nature of Parkinson's disease: from triggers to spreading pathology.Journal of medical genetics, , Volume: 57, Issue:2, 2020
Histamine-4 receptor antagonist JNJ7777120 inhibits pro-inflammatory microglia and prevents the progression of Parkinson-like pathology and behaviour in a rat model.Brain, behavior, and immunity, , Volume: 76, 2019
Neuroprotective role of kolaviron in striatal redo-inflammation associated with rotenone model of Parkinson's disease.Neurotoxicology, , Volume: 73, 2019
Should Age at Onset of Parkinsonism be the End Point of Interest in Investigations of the Link Between Exosomal α-Synuclein and Manganese Exposure in Welders?Journal of occupational and environmental medicine, , Volume: 61, Issue:12, 2019
Chronic Mild Gut Inflammation Accelerates Brain Neuropathology and Motor Dysfunction in α-Synuclein Mutant Mice.Neuromolecular medicine, , Volume: 21, Issue:3, 2019
Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease.Neuron, , 08-21, Volume: 103, Issue:4, 2019
Caffeic acid reduces A53T α-synuclein by activating JNK/Bcl-2-mediated autophagy in vitro and improves behaviour and protects dopaminergic neurons in a mouse model of Parkinson's disease.Pharmacological research, , Volume: 150, 2019
Proteomics; applications in familial Parkinson's disease.Journal of neurochemistry, , Volume: 151, Issue:4, 2019
Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models.Neurobiology of disease, , Volume: 124, 2019
Progressive supranuclear palsy, multiple system atrophy and corticobasal degeneration.Handbook of clinical neurology, , Volume: 165, 2019
The usual suspects, dopamine and alpha-synuclein, conspire to cause neurodegeneration.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:2, 2019
Impairment of Nrf2- and Nitrergic-Mediated Gastrointestinal Motility in an MPTP Mouse Model of Parkinson's Disease.Digestive diseases and sciences, , Volume: 64, Issue:12, 2019
Activation of the immunoproteasome protects SH-SY5Y cells from the toxicity of rotenone.Neurotoxicology, , Volume: 73, 2019
GBA1-associated parkinsonism: new insights and therapeutic opportunities.Current opinion in neurology, , Volume: 32, Issue:4, 2019
Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis.Nature communications, , 03-07, Volume: 10, Issue:1, 2019
α-synuclein oligomers enhance astrocyte-induced synapse formation through TGF-β1 signaling in a Parkinson's disease model.Journal of neurochemistry, , Volume: 150, Issue:2, 2019
Thymoquinone prevents neurodegeneration against MPTP in vivo and modulates α-synuclein aggregation in vitro.Neurochemistry international, , Volume: 128, 2019
Ultrasensitive Detection of Aggregated α-Synuclein in Glial Cells, Human Cerebrospinal Fluid, and Brain Tissue Using the RT-QuIC Assay: New High-Throughput Neuroimmune Biomarker Assay for Parkinsonian Disorders.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 14, Issue:3, 2019
α-Synuclein Expression Is Preserved in Substantia Nigra GABAergic Fibers of Young and Aged Neurotoxin-Treated Rhesus Monkeys.Cell transplantation, , Volume: 28, Issue:4, 2019
Rebamipide Mitigates Impairments in Mitochondrial Function and Bioenergetics with α-Synuclein Pathology in 6-OHDA-Induced Hemiparkinson's Model in Rats.Neurotoxicity research, , Volume: 35, Issue:3, 2019
Coexisting Lewy body disease and clinical parkinsonism in frontotemporal lobar degeneration.Neurology, , 05-21, Volume: 92, Issue:21, 2019
Aquaporin-4 deficiency reduces TGF-β1 in mouse midbrains and exacerbates pathology in experimental Parkinson's disease.Journal of cellular and molecular medicine, , Volume: 23, Issue:4, 2019
Serotonergic pathology and Braak's staging hypothesis in Parkinson's disease.The Lancet. Neurology, , Volume: 18, Issue:8, 2019
α-Synuclein real-time quaking-induced conversion in the cerebrospinal fluid of uncertain cases of parkinsonism.Annals of neurology, , Volume: 85, Issue:5, 2019
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Effects and mechanism of epigallocatechin-3-gallate on apoptosis and mTOR/AKT/GSK-3β pathway in substantia nigra neurons in Parkinson rats.Neuroreport, , 01-16, Volume: 30, Issue:2, 2019
Toll-like receptors and their therapeutic potential in Parkinson's disease and α-synucleinopathies.Brain, behavior, and immunity, , Volume: 81, 2019
Juvenile parkinsonism: Differential diagnosis, genetics, and treatment.Parkinsonism & related disorders, , Volume: 67, 2019
Alpha-synuclein at the nexus of genes and environment: the impact of environmental enrichment and stress on brain health and disease.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Acupuncture Inhibits the Increase in Alpha-Synuclein by Modulating SGK1 in an MPTP Induced Parkinsonism Mouse Model.The American journal of Chinese medicine, , Volume: 47, Issue:3, 2019
Tyrosol, a simple phenol from EVOO, targets multiple pathogenic mechanisms of neurodegeneration in a C. elegans model of Parkinson's disease.Neurobiology of aging, , Volume: 82, 2019
Female Sex and Brain-Selective Estrogen Benefit α-Synuclein Tetramerization and the PD-like Motor Syndrome in 3K Transgenic Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 09-18, Volume: 39, Issue:38, 2019
Ginsenoside Rb1 prevents MPTP-induced changes in hippocampal memory via regulation of the α-synuclein/PSD-95 pathway.Aging, , 04-04, Volume: 11, Issue:7, 2019
Trichloroethylene and its metabolite TaClo lead to degeneration of substantia nigra dopaminergic neurones: Effects in wild type and human A30P mutant α-synuclein mice.Neuroscience letters, , 10-15, Volume: 711, 2019
Phytochemicals Bridging Autophagy Induction and Alpha-Synuclein Degradation in Parkinsonism.International journal of molecular sciences, , Jul-03, Volume: 20, Issue:13, 2019
High lithium levels in tobacco may account for reduced incidences of both Parkinson's disease and melanoma in smokers through enhanced β-catenin-mediated activity.Medical hypotheses, , Volume: 131, 2019
Seeding of protein aggregation causes cognitive impairment in rat model of cortical synucleinopathy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:11, 2019
Glial HMOX1 expression promotes central and peripheral α-synuclein dysregulation and pathogenicity in parkinsonian mice.Glia, , Volume: 67, Issue:9, 2019
Aβ, Tau, and α-Synuclein aggregation and integrated role of PARK2 in the regulation and clearance of toxic peptides.Neuropeptides, , Volume: 78, 2019
Isolated nigral degeneration without pathological protein aggregation in autopsied brains with LRRK2 p.R1441H homozygous and heterozygous mutations.Acta neuropathologica communications, , 10-17, Volume: 6, Issue:1, 2018
The different faces of the p. A53T alpha-synuclein mutation: A screening of Greek patients with parkinsonism and/or dementia.Neuroscience letters, , 04-13, Volume: 672, 2018
Modeling Parkinson's Disease in C. elegans.Journal of Parkinson's disease, , Volume: 8, Issue:1, 2018
The Relevance of Iron in the Pathogenesis of Multiple System Atrophy: A Viewpoint.Journal of Alzheimer's disease : JAD, , Volume: 61, Issue:4, 2018
P75 Involved in the Ubiquitination of α-synuclein in Rotenone-based Parkinson's Disease Models.Neuroscience, , 09-15, Volume: 388, 2018
Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation.Molecular neurodegeneration, , 08-09, Volume: 13, Issue:1, 2018
DNAJC12: A molecular chaperone involved in proteostasis, PKU, biogenic amines metabolism and beyond?Molecular genetics and metabolism, , Volume: 123, Issue:3, 2018
Parkinsonism due to A53E α-synuclein gene mutation: Clinical, genetic, epigenetic, and biochemical features.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:12, 2018
Neuroprotective effect of treadmill exercise possibly via regulation of lysosomal degradation molecules in mice with pharmacologically induced Parkinson's disease.The journal of physiological sciences : JPS, , Volume: 68, Issue:5, 2018
Genetics of Parkinson's disease and related disorders.Journal of medical genetics, , Volume: 55, Issue:2, 2018
Dynamic footprint based locomotion sway assessment in α-synucleinopathic mice using Fast Fourier Transform and Low Pass Filter.Journal of neuroscience methods, , 02-15, Volume: 296, 2018
Susceptibility MRI captures nigral pathology in patients with parkinsonian syndromes.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:9, 2018
Recent advances in neuropathology, biomarkers and therapeutic approach of multiple system atrophy.Journal of neurology, neurosurgery, and psychiatry, , Volume: 89, Issue:2, 2018
Parkinson's disease-like burst firing activity in subthalamic nucleus induced by AAV-α-synuclein is normalized by LRRK2 modulation.Neurobiology of disease, , Volume: 116, 2018
Parkinson Diseases in the 2020s and Beyond: Replacing Clinico-Pathologic Convergence With Systems Biology Divergence.Journal of Parkinson's disease, , Volume: 8, Issue:s1, 2018
Altered Volatile Organic Compound Profile in Transgenic Rats Bearing A53T Mutation of Human α-Synuclein: Comparison with Dopaminergic and Serotonergic Denervation.ACS chemical neuroscience, , 02-21, Volume: 9, Issue:2, 2018
An unexpected improvement in spatial learning and memory ability in alpha-synuclein A53T transgenic mice.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 125, Issue:2, 2018
LncRNA SNHG1 promotes α-synuclein aggregation and toxicity by targeting miR-15b-5p to activate SIAH1 in human neuroblastoma SH-SY5Y cells.Neurotoxicology, , Volume: 68, 2018
[GBA mutations and Parkinson's disease].Sheng li xue bao : [Acta physiologica Sinica], , Jun-25, Volume: 70, Issue:3, 2018
Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease.Neuron, , 10-10, Volume: 100, Issue:1, 2018
RTP801 is a critical factor in the neurodegeneration process of A53T α-synuclein in a mouse model of Parkinson's disease under chronic restraint stress.British journal of pharmacology, , Volume: 175, Issue:4, 2018
Serum Response Factor Promotes Dopaminergic Neuron Survival via Activation of Beclin 1-Dependent Autophagy.Neuroscience, , 02-10, Volume: 371, 2018
Hydroxysafflor yellow A promotes α-synuclein clearance via regulating autophagy in rotenone-induced Parkinson's disease mice.Folia neuropathologica, , Volume: 56, Issue:2, 2018
Long non-coding RNA NEAT1 mediates the toxic of Parkinson's disease induced by MPTP/MPP+ via regulation of gene expression.Clinical and experimental pharmacology & physiology, , Volume: 45, Issue:8, 2018
MANF protects dopamine neurons and locomotion defects from a human α-synuclein induced Parkinson's disease model in C. elegans by regulating ER stress and autophagy pathways.Experimental neurology, , Volume: 308, 2018
Impact of DHA intake in a mouse model of synucleinopathy.Experimental neurology, , Volume: 301, Issue:Pt A, 2018
α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism.Molecular neurodegeneration, , 01-08, Volume: 13, Issue:1, 2018
When Do α-Synucleinopathies Start? An Epidemiological Timeline: A Review.JAMA neurology, , 04-01, Volume: 75, Issue:4, 2018
Prion-like propagation of α-synuclein in the gut-brain axis.Brain research bulletin, , Volume: 140, 2018
Acrolein acts as a neurotoxin in the nigrostriatal dopaminergic system of rat: involvement of α-synuclein aggregation and programmed cell death.Scientific reports, , 04-12, Volume: 7, 2017
Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates.Acta neuropathologica communications, , 06-15, Volume: 5, Issue:1, 2017
Mutant A53T α-Synuclein Improves Rotarod Performance Before Motor Deficits and Affects Metabolic Pathways.Neuromolecular medicine, , Volume: 19, Issue:1, 2017
AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson's disease.Acta neuropathologica communications, , Feb-01, Volume: 5, Issue:1, 2017
Deferiprone Rescues Behavioral Deficits Induced by Mild Iron Exposure in a Mouse Model of Alpha-Synuclein Aggregation.Neuromolecular medicine, , Volume: 19, Issue:2-3, 2017
Reassessment of subacute MPTP-treated mice as animal model of Parkinson's disease.Acta pharmacologica Sinica, , Volume: 38, Issue:10, 2017
The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease.Acta neuropathologica communications, , 06-28, Volume: 5, Issue:1, 2017
Sirtuin 3 rescues neurons through the stabilisation of mitochondrial biogenetics in the virally-expressing mutant α-synuclein rat model of parkinsonism.Neurobiology of disease, , Volume: 106, 2017
α-Synuclein and Parkinsonism: Updates and Future Perspectives.Current neurology and neuroscience reports, , Volume: 17, Issue:4, 2017
Hereditary Parkinsonism-Associated Genetic Variations in PARK9 Locus Lead to Functional Impairment of ATPase Type 13A2.Current protein & peptide science, , Volume: 18, Issue:7, 2017
Allelic difference in Mhc2ta confers altered microglial activation and susceptibility to α-synuclein-induced dopaminergic neurodegeneration.Neurobiology of disease, , Volume: 106, 2017
Decreased Expression of hsa-miR-4274 in Cerebrospinal Fluid of Normal Pressure Hydrocephalus Mimics with Parkinsonian Syndromes.Journal of Alzheimer's disease : JAD, , Volume: 56, Issue:1, 2017
Effects of titanium dioxide nanoparticles exposure on parkinsonism in zebrafish larvae and PC12.Chemosphere, , Volume: 173, 2017
Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice.Acta neuropathologica communications, , 03-14, Volume: 5, Issue:1, 2017
DNAJC12 and dopa-responsive nonprogressive parkinsonism.Annals of neurology, , Volume: 82, Issue:4, 2017
Subcutaneous rotenone rat model of Parkinson's disease: Dose exploration study.Brain research, , 01-15, Volume: 1655, 2017
Neuropathology of genetic synucleinopathies with parkinsonism: Review of the literature.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:11, 2017
Identification of candidate cerebrospinal fluid biomarkers in parkinsonism using quantitative proteomics.Parkinsonism & related disorders, , Volume: 37, 2017
Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy.Neurobiology of disease, , Volume: 104, 2017
mTOR Signaling in Parkinson's Disease.Neuromolecular medicine, , Volume: 19, Issue:1, 2017
Propagation of pathological α-synuclein in marmoset brain.Acta neuropathologica communications, , Feb-02, Volume: 5, Issue:1, 2017
Survival and Causes of Death Among People With Clinically Diagnosed Synucleinopathies With Parkinsonism: A Population-Based Study.JAMA neurology, , 07-01, Volume: 74, Issue:7, 2017
Is Multiple System Atrophy a New Prion Disorder?Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:3, 2016
Neurodegeneration in tauopathies and synucleinopathies.Revue neurologique, , Volume: 172, Issue:11, 2016
Pedunculopontine cell loss and protein aggregation direct microglia activation in parkinsonian rats.Brain structure & function, , Volume: 221, Issue:4, 2016
α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.Human molecular genetics, , Mar-15, Volume: 25, Issue:6, 2016
Neuroprotection of inositol hexaphosphate and changes of mitochondrion mediated apoptotic pathway and α-synuclein aggregation in 6-OHDA induced parkinson's disease cell model.Brain research, , Feb-15, Volume: 1633, 2016
Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model.Acta neuropathologica communications, , 08-22, Volume: 4, Issue:1, 2016
The Bcl-2 homologue Buffy rescues α-synuclein-induced Parkinson disease-like phenotypes in Drosophila.BMC neuroscience, , 05-18, Volume: 17, Issue:1, 2016
Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model by targeting α-synuclein abnormalities in the substantia nigra.Toxicology letters, , Jan-22, Volume: 243, 2016
Phenotypic spectrum of alpha-synuclein mutations: New insights from patients and cellular models.Parkinsonism & related disorders, , Volume: 22 Suppl 1, 2016
Levodopa-Induced Motor and Dopamine Receptor Changes in Caenorhabditis elegans Overexpressing Human Alpha-Synuclein.Neuro-degenerative diseases, , Volume: 16, Issue:3-4, 2016
α-Synuclein vaccination modulates regulatory T cell activation and microglia in the absence of brain pathology.Journal of neuroinflammation, , Apr-07, Volume: 13, Issue:1, 2016
Autosomal dominant Parkinson's disease caused by SNCA duplications.Parkinsonism & related disorders, , Volume: 22 Suppl 1, 2016
Delivery of Dual Drug Loaded Lipid Based Nanoparticles across the Blood-Brain Barrier Impart Enhanced Neuroprotection in a Rotenone Induced Mouse Model of Parkinson's Disease.ACS chemical neuroscience, , 12-21, Volume: 7, Issue:12, 2016
High-content analysis of α-synuclein aggregation and cell death in a cellular model of Parkinson's disease.Journal of neuroscience methods, , Mar-01, Volume: 261, 2016
An 11-mer Amyloid Beta Peptide Fragment Provokes Chemical Mutations and Parkinsonian Biomarker Aggregation in Dopaminergic Cells: A Novel Road Map for "Transfected" Parkinson's.ACS chemical neuroscience, , 11-16, Volume: 7, Issue:11, 2016
Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism.Proceedings of the National Academy of Sciences of the United States of America, , Apr-12, Volume: 113, Issue:15, 2016
Alterations in Activity-Dependent Neuroprotective Protein in Sporadic and Experimental Parkinson's Disease.Journal of Parkinson's disease, , Volume: 6, Issue:1, 2016
Role of cytochrome c in α-synuclein radical formation: implications of α-synuclein in neuronal death in Maneb- and paraquat-induced model of Parkinson's disease.Molecular neurodegeneration, , 11-24, Volume: 11, Issue:1, 2016
Thiol Oxidation by Diamide Leads to Dopaminergic Degeneration and Parkinsonism Phenotype in Mice: A Model for Parkinson's Disease.Antioxidants & redox signaling, , 08-10, Volume: 25, Issue:5, 2016
A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 07-13, Volume: 36, Issue:28, 2016
Geniposide reduces α-synuclein by blocking microRNA-21/lysosome-associated membrane protein 2A interaction in Parkinson disease models.Brain research, , 08-01, Volume: 1644, 2016
Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC α-synuclein transgenic rat model of Parkinson's disease.Neurobiology of disease, , Volume: 85, 2016
Transmission of α-synucleinopathy from olfactory structures deep into the temporal lobe.Molecular neurodegeneration, , 06-30, Volume: 11, Issue:1, 2016
Mesenchymal stem cells enhance α-synuclein clearance via M2 microglia polarization in experimental and human parkinsonian disorder.Acta neuropathologica, , Volume: 132, Issue:5, 2016
Inhibition of Rho-kinase by Fasudil protects dopamine neurons and attenuates inflammatory response in an intranasal lipopolysaccharide-mediated Parkinson's model.The European journal of neuroscience, , Volume: 43, Issue:1, 2016
Alpha-, Beta-, and Gamma-synuclein Quantification in Cerebrospinal Fluid by Multiple Reaction Monitoring Reveals Increased Concentrations in Alzheimer's and Creutzfeldt-Jakob Disease but No Alteration in Synucleinopathies.Molecular & cellular proteomics : MCP, , Volume: 15, Issue:10, 2016
Expanding the prion disease repertoire.Proceedings of the National Academy of Sciences of the United States of America, , Sep-22, Volume: 112, Issue:38, 2015
Tea polyphenols alleviate motor impairments, dopaminergic neuronal injury, and cerebral α-synuclein aggregation in MPTP-intoxicated parkinsonian monkeys.Neuroscience, , Feb-12, Volume: 286, 2015
Cyclosporine A and MnTMPyP Alleviate α-Synuclein Expression and Aggregation in Cypermethrin-Induced Parkinsonism.Molecular neurobiology, , Volume: 52, Issue:3, 2015
Parkinson's disease and alpha-synucleinopathies: from arising pathways to therapeutic challenge.Central nervous system agents in medicinal chemistry, , Volume: 15, Issue:2, 2015
Noradrenergic and serotonergic neurochemistry arising from intranasal inoculation with α-synuclein aggregates which incite parkinsonian-like symptoms.Behavioural brain research, , Feb-15, Volume: 279, 2015
Rotenone impairs autophagic flux and lysosomal functions in Parkinson's disease.Neuroscience, , Jan-22, Volume: 284, 2015
VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jul-22, Volume: 35, Issue:29, 2015
Toward peptide-based inhibitors as therapies for Parkinson's disease.Future medicinal chemistry, , Volume: 7, Issue:16, 2015
Comparison between α-synuclein wild-type and A53T mutation in a progressive Parkinson's disease model.Biochemical and biophysical research communications, , Sep-04, Volume: 464, Issue:4, 2015
Survival in synucleinopathies: A prospective cohort study.Neurology, , Nov-03, Volume: 85, Issue:18, 2015
α-Synuclein staging in the amygdala of a Parkinson's disease model: cell types involved.The European journal of neuroscience, , Volume: 41, Issue:1, 2015
A Genetic Mouse Model of Parkinson's Disease Shows Involuntary Movements and Increased Postsynaptic Sensitivity to Apomorphine.Molecular neurobiology, , Volume: 52, Issue:3, 2015
Clinicopathological Study of Patients With C9ORF72-Associated Frontotemporal Dementia Presenting With Delusions.Journal of geriatric psychiatry and neurology, , Volume: 28, Issue:2, 2015
Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease.Human molecular genetics, , Dec-01, Volume: 24, Issue:23, 2015
Understanding Caffeine's Role in Attenuating the Toxicity of α-Synuclein Aggregates: Implications for Risk of Parkinson's Disease.ACS chemical neuroscience, , Sep-16, Volume: 6, Issue:9, 2015
Link between the SNCA gene and parkinsonism.Neurobiology of aging, , Volume: 36, Issue:3, 2015
MicroRNA-214 participates in the neuroprotective effect of Resveratrol via inhibiting α-synuclein expression in MPTP-induced Parkinson's disease mouse.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 74, 2015
Gastric motor dysfunctions in Parkinson's disease: Current pre-clinical evidence.Parkinsonism & related disorders, , Volume: 21, Issue:12, 2015
Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease.Human molecular genetics, , Oct-15, Volume: 24, Issue:R1, 2015
Multiple sclerosis and Parkinson's disease: the two faces of neurodegeneration. Report of the first Greek case and review of the literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 36, Issue:12, 2015
α-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson's disease occurs independent of ATP13A2 (PARK9).Neurobiology of disease, , Volume: 73, 2015
α-Synuclein oligomers pump it up!The EMBO journal, , Oct-01, Volume: 34, Issue:19, 2015
shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model.The Journal of clinical investigation, , Jul-01, Volume: 125, Issue:7, 2015
Fractalkine over expression suppresses α-synuclein-mediated neurodegeneration.Molecular therapy : the journal of the American Society of Gene Therapy, , Volume: 23, Issue:1, 2015
Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.Proceedings of the National Academy of Sciences of the United States of America, , Sep-22, Volume: 112, Issue:38, 2015
Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy.Molecular neurodegeneration, , Mar-19, Volume: 10, 2015
α-synuclein assemblies sequester neuronal α3-Na+/K+-ATPase and impair Na+ gradient.The EMBO journal, , Oct-01, Volume: 34, Issue:19, 2015
GSK-3β dysregulation contributes to parkinson's-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and α-synuclein.Cell death and differentiation, , Volume: 22, Issue:5, 2015
Increased 14-3-3 phosphorylation observed in Parkinson's disease reduces neuroprotective potential of 14-3-3 proteins.Neurobiology of disease, , Volume: 79, 2015
α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Apr-08, Volume: 35, Issue:14, 2015
A Fluorescence Resonance Energy Transfer Assay For Monitoring α- Synclein Aggregation in a Caenorhabditis Elegans Model For Parkinson's Disease.CNS & neurological disorders drug targets, , Volume: 14, Issue:8, 2015
Gaucher-Associated Parkinsonism.Cellular and molecular neurobiology, , Volume: 35, Issue:6, 2015
α-Synuclein and nonhuman primate models of Parkinson's disease.Journal of neuroscience methods, , Nov-30, Volume: 255, 2015
Environment-contact administration of rotenone: A new rodent model of Parkinson's disease.Behavioural brain research, , Nov-01, Volume: 294, 2015
Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice.Molecular neurodegeneration, , Jul-30, Volume: 10, 2015
Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons.Neurobiology of disease, , Volume: 69, 2014
Immunolocalization of human alpha-synuclein in the Thy1-aSyn ("Line 61") transgenic mouse line.Neuroscience, , Sep-26, Volume: 277, 2014
Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice.Neurobiology of disease, , Volume: 69, 2014
Mosaicism of alpha-synuclein gene rearrangements: report of two unrelated cases of early-onset parkinsonism.Parkinsonism & related disorders, , Volume: 20, Issue:5, 2014
Molecular inscription of environmental information into protein suprastructures: temperature effects on unit assembly of α-synuclein oligomers into polymorphic amyloid fibrils.The Biochemical journal, , Dec-01, Volume: 464, Issue:2, 2014
Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jul-09, Volume: 34, Issue:28, 2014
A 6.4 Mb duplication of the α-synuclein locus causing frontotemporal dementia and Parkinsonism: phenotype-genotype correlations.JAMA neurology, , Volume: 71, Issue:9, 2014
The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset.Acta neuropathologica, , Volume: 127, Issue:5, 2014
Multiple system atrophy of the cerebellar type: clinical state of the art.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:3, 2014
Non-motor parkinsonian pathology in aging A53T α-synuclein mice is associated with progressive synucleinopathy and altered enzymatic function.Journal of neurochemistry, , Volume: 128, Issue:4, 2014
Multifunctional D2/D3 agonist D-520 with high in vivo efficacy: modulator of toxicity of alpha-synuclein aggregates.ACS chemical neuroscience, , Aug-20, Volume: 5, Issue:8, 2014
Zn²⁺ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation.Human molecular genetics, , Jun-01, Volume: 23, Issue:11, 2014
Ellagic acid mitigates SNO-PDI induced aggregation of Parkinsonian biomarkers.ACS chemical neuroscience, , Dec-17, Volume: 5, Issue:12, 2014
Long-term heat shock proteins (HSPs) induction by carbenoxolone improves hallmark features of Parkinson's disease in a rotenone-based model.Neuropharmacology, , Volume: 79, 2014
Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental Parkinson's disease.Neurobiology of disease, , Volume: 69, 2014
Acetylcorynoline attenuates dopaminergic neuron degeneration and α-synuclein aggregation in animal models of Parkinson's disease.Neuropharmacology, , Volume: 82, 2014
[Clinical picture and diagnostic criteria of multiple system atrophy].Rinsho shinkeigaku = Clinical neurology, , Volume: 54, Issue:12, 2014
CSF α-synuclein and UCH-L1 levels in Parkinson's disease and atypical parkinsonian disorders.Parkinsonism & related disorders, , Volume: 20, Issue:4, 2014
Correlation between the biochemical pathways altered by mutated parkinson-related genes and chronic exposure to manganese.Neurotoxicology, , Volume: 44, 2014
Deciphering the glycolipid code of Alzheimer's and Parkinson's amyloid proteins allowed the creation of a universal ganglioside-binding peptide.PloS one, , Volume: 9, Issue:8, 2014
Intranasal administration of alpha-synuclein aggregates: a Parkinson's disease model with behavioral and neurochemical correlates.Behavioural brain research, , Apr-15, Volume: 263, 2014
ATP13A2/PARK9 regulates secretion of exosomes and α-synuclein.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-12, Volume: 34, Issue:46, 2014
Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease.Neurobiology of disease, , Volume: 64, 2014
Glucocerebrosidase in the pathogenesis and treatment of Parkinson disease.Proceedings of the National Academy of Sciences of the United States of America, , Feb-26, Volume: 110, Issue:9, 2013
Parkinsonism, dementia and glucocerebrosidase mutations.Journal of neurology, , Volume: 260, Issue:5, 2013
Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model.Proceedings of the National Academy of Sciences of the United States of America, , Oct-15, Volume: 110, Issue:42, 2013
Primary progressive aphasia with parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:6, 2013
Parkinson's disease and α-synuclein: passing it on.CNS & neurological disorders drug targets, , Feb-01, Volume: 12, Issue:1, 2013
Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits.Human molecular genetics, , May-15, Volume: 22, Issue:10, 2013
Alpha-synuclein aggregates in epicardial fat tissue in living subjects without parkinsonism.Parkinsonism & related disorders, , Volume: 19, Issue:1, 2013
Immune effects of optimized DNA vaccine and protective effects in a MPTP model of Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 34, Issue:9, 2013
An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker.NMR in biomedicine, , Volume: 26, Issue:1, 2013
Tyrosine kinase inhibition facilitates autophagic SNCA/α-synuclein clearance.Autophagy, , Volume: 9, Issue:8, 2013
Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies.Proceedings of the National Academy of Sciences of the United States of America, , Feb-26, Volume: 110, Issue:9, 2013
Movement disorders in 2012: Advancing research towards novel therapeutic approaches.Nature reviews. Neurology, , Volume: 9, Issue:2, 2013
Decreased parkin solubility is associated with impairment of autophagy in the nigrostriatum of sporadic Parkinson's disease.Neuroscience, , Mar-01, Volume: 232, 2013
SUMO and Parkinson's disease.Neuromolecular medicine, , Volume: 15, Issue:4, 2013
Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of α-synuclein in Parkinson's disease models.Human molecular genetics, , Aug-15, Volume: 22, Issue:16, 2013
Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment.Experimental neurology, , Volume: 240, 2013
Alpha-synuclein gene duplication: marked intrafamilial variability in two novel pedigrees.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:6, 2013
Telmisartan attenuates MPTP induced dopaminergic degeneration and motor dysfunction through regulation of α-synuclein and neurotrophic factors (BDNF and GDNF) expression in C57BL/6J mice.Neuropharmacology, , Volume: 73, 2013
Direct detection of alpha synuclein oligomers in vivo.Acta neuropathologica communications, , May-09, Volume: 1, 2013
[Α-synuclein as a biomarker for early diagnosis of Parkinsonism].Rinsho shinkeigaku = Clinical neurology, , Volume: 53, Issue:11, 2013
Reynosin protects against neuronal toxicity in dopamine-induced SH-SY5Y cells and 6-hydroxydopamine-lesioned rats as models of Parkinson's disease: Reciprocal up-regulation of E6-AP and down-regulation of α-synuclein.Brain research, , Aug-02, Volume: 1524, 2013
The association between ß-glucocerebrosidase mutations and parkinsonism.Current neurology and neuroscience reports, , Volume: 13, Issue:8, 2013
Differentiation of progressive supranuclear palsy: clinical, imaging and laboratory tools.Acta neurologica Scandinavica, , Volume: 127, Issue:5, 2013
Potential neuroprotective effect of ibuprofen, insights from the mice model of Parkinson's disease.Pharmacological reports : PR, , Volume: 65, Issue:5, 2013
Increased SUMO-1 expression in the unilateral rotenone-lesioned mouse model of Parkinson's disease.Neuroscience letters, , Jun-07, Volume: 544, 2013
Toxic equine parkinsonism: an immunohistochemical study of 10 horses with nigropallidal encephalomalacia.Veterinary pathology, , Volume: 49, Issue:2, 2012
Variant in the 3' region of SNCA associated with Parkinson's disease and serum α-synuclein levels.Journal of neurology, , Volume: 259, Issue:3, 2012
Late-onset Parkinsonism in NFκB/c-Rel-deficient mice.Brain : a journal of neurology, , Volume: 135, Issue:Pt 9, 2012
DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats.Brain research bulletin, , Sep-01, Volume: 88, Issue:6, 2012
Update on genetics of parkinsonism.Neuro-degenerative diseases, , Volume: 10, Issue:1-4, 2012
Autosomal dominant parkinsonism: its etiologies and differential diagnoses.Parkinsonism & related disorders, , Volume: 18 Suppl 1, 2012
α-Synuclein pathology in the amyotrophic lateral sclerosis/parkinsonism dementia complex in the Kii Peninsula, Japan.Journal of neuropathology and experimental neurology, , Volume: 71, Issue:7, 2012
A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease.British journal of pharmacology, , Volume: 166, Issue:3, 2012
Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease.Brain : a journal of neurology, , Volume: 135, Issue:Pt 7, 2012
A30P α-synuclein impairs dopaminergic fiber regeneration and interacts with L-DOPA replacement in MPTP-treated mice.Neurobiology of disease, , Volume: 45, Issue:1, 2012
Young-onset parkinsonism due to homozygous duplication of α-synuclein in a consanguineous family.Movement disorders : official journal of the Movement Disorder Society, , Volume: 27, Issue:14, 2012
Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jul-04, Volume: 32, Issue:27, 2012
Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice.Science (New York, N.Y.), , Nov-16, Volume: 338, Issue:6109, 2012
Overexpression of parkin ameliorates dopaminergic neurodegeneration induced by 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.PloS one, , Volume: 7, Issue:6, 2012
Widespread Lewy body and tau accumulation in childhood and adult onset dystonia-parkinsonism cases with PLA2G6 mutations.Neurobiology of aging, , Volume: 33, Issue:4, 2012
Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-21, Volume: 32, Issue:12, 2012
Emerging neurotoxic mechanisms in environmental factors-induced neurodegeneration.Neurotoxicology, , Volume: 33, Issue:4, 2012
Paraquat, but not maneb, induces synucleinopathy and tauopathy in striata of mice through inhibition of proteasomal and autophagic pathways.PloS one, , Volume: 7, Issue:1, 2012
Pathobiochemical effect of acylated steryl-β-glucoside on aggregation and cytotoxicity of α-synuclein.Neurochemical research, , Volume: 37, Issue:6, 2012
A family with Parkinsonism, essential tremor, restless legs syndrome, and depression.Neurology, , May-10, Volume: 76, Issue:19, 2011
New insights into atypical parkinsonism.Current opinion in neurology, , Volume: 24, Issue:4, 2011
Spinal cord and parkinsonism: neuromorphological evidences in humans and experimental studies.Journal of chemical neuroanatomy, , Volume: 42, Issue:4, 2011
Olfactory neuron-specific expression of A30P α-synuclein exacerbates dopamine deficiency and hyperactivity in a novel conditional model of early Parkinson's disease stages.Neurobiology of disease, , Volume: 44, Issue:2, 2011
Lithium protects against oxidative stress-mediated cell death in α-synuclein-overexpressing in vitro and in vivo models of Parkinson's disease.Journal of neuroscience research, , Volume: 89, Issue:10, 2011
An α-synuclein AAV gene silencing vector ameliorates a behavioral deficit in a rat model of Parkinson's disease, but displays toxicity in dopamine neurons.Brain research, , Jun-13, Volume: 1395, 2011
Direct MRI-guided stereotaxic viral mediated gene transfer of alpha-synuclein in the Göttingen minipig CNS.Acta neurobiologiae experimentalis, , Volume: 71, Issue:4, 2011
Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease.BMC neuroscience, , Aug-03, Volume: 12, 2011
Exploring the link between glucocerebrosidase mutations and parkinsonism.Trends in molecular medicine, , Volume: 17, Issue:9, 2011
Age and α-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling.Neurobiology of disease, , Volume: 44, Issue:2, 2011
Mice lacking major brain gangliosides develop parkinsonism.Neurochemical research, , Volume: 36, Issue:9, 2011
Chronic exposure to manganese decreases striatal dopamine turnover in human alpha-synuclein transgenic mice.Neuroscience, , Apr-28, Volume: 180, 2011
Interference of alpha-synuclein with cAMP/PKA-dependent CREB signaling for tyrosine hydroxylase gene expression in SK-N-BE(2)C cells.Archives of pharmacal research, , Volume: 34, Issue:5, 2011
Transfer of host-derived α synuclein to grafted dopaminergic neurons in rat.Neurobiology of disease, , Volume: 43, Issue:3, 2011
Effect of Ser-129 phosphorylation on interaction of α-synuclein with synaptic and cellular membranes.The Journal of biological chemistry, , Oct-14, Volume: 286, Issue:41, 2011
Oral administration of rotenone using a gavage and image analysis of alpha-synuclein inclusions in the enteric nervous system.Journal of visualized experiments : JoVE, , Oct-26, Issue:44, 2010
alpha-Synuclein- and MPTP-generated rodent models of Parkinson's disease and the study of extracellular striatal dopamine dynamics: a microdialysis approach.CNS & neurological disorders drug targets, , Volume: 9, Issue:4, 2010
Non-invasive evaluation of nigrostriatal neuropathology in a proteasome inhibitor rodent model of Parkinson's disease.BMC neuroscience, , Jan-05, Volume: 11, 2010
A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death.Neurobiology of aging, , Volume: 31, Issue:1, 2010
Identifying PD-causing genes and genetic susceptibility factors: current approaches and future prospects.Progress in brain research, , Volume: 183, 2010
MPTP-induced parkinsonism extends to a subclass of TH-positive neurons in the gut.Brain research, , Oct-08, Volume: 1355, 2010
Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau.BioEssays : news and reviews in molecular, cellular and developmental biology, , Volume: 32, Issue:3, 2010
Baicalein reduces E46K alpha-synuclein aggregation in vitro and protects cells against E46K alpha-synuclein toxicity in cell models of familiar Parkinsonism.Journal of neurochemistry, , Volume: 114, Issue:2, 2010
Roll on genetics of PARK and Parkinsonism in the developing world.Journal of neurology, neurosurgery, and psychiatry, , Volume: 81, Issue:2, 2010
Vulnerability of peripheral catecholaminergic neurons to MPTP is not regulated by alpha-synuclein.Neurobiology of disease, , Volume: 38, Issue:1, 2010
Forebrain overexpression of alpha-synuclein leads to early postnatal hippocampal neuron loss and synaptic disruption.Experimental neurology, , Volume: 221, Issue:1, 2010
alpha-Synuclein multiplication analysis in Italian familial Parkinson disease.Parkinsonism & related disorders, , Volume: 16, Issue:3, 2010
α-Synuclein transgenic mice reveal compensatory increases in Parkinson's disease-associated proteins DJ-1 and parkin and have enhanced α-synuclein and PINK1 levels after rotenone treatment.Journal of molecular neuroscience : MN, , Volume: 42, Issue:2, 2010
Clinical implications of gene discovery in Parkinson's disease and parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Volume: 25 Suppl 1, 2010
Evaluation of the Braak staging scheme for Parkinson's disease: introduction to a panel presentation.Movement disorders : official journal of the Movement Disorder Society, , Volume: 25 Suppl 1, 2010
Mendelian forms of Parkinson's disease.Biochimica et biophysica acta, , Volume: 1792, Issue:7, 2009
The lipid peroxidation metabolite 4-oxo-2-nonenal cross-links alpha-synuclein causing rapid formation of stable oligomers.Biochemical and biophysical research communications, , Jan-23, Volume: 378, Issue:4, 2009
Alpha-synuclein pathology and Parkinsonism associated with POLG1 mutations and multiple mitochondrial DNA deletions.Neuropathology and applied neurobiology, , Volume: 35, Issue:1, 2009
The ALS/PDC syndrome of Guam and the cycad hypothesis.Neurology, , Feb-03, Volume: 72, Issue:5, 2009
Juvenile parkinsonism.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, , Volume: 13, Issue:3, 2009
Neuroprotective effect of the antiparkinsonian drug pramipexole against nigrostriatal dopaminergic degeneration in rotenone-treated mice.Neurochemistry international, , Volume: 55, Issue:8, 2009
Degeneration in different parkinsonian syndromes relates to astrocyte type and astrocyte protein expression.Journal of neuropathology and experimental neurology, , Volume: 68, Issue:10, 2009
Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models.Nature chemical biology, , Volume: 5, Issue:9, 2009
Familial Parkinsonism and early onset Parkinson's disease in a Brazilian movement disorders clinic: phenotypic characterization and frequency of SNCA, PRKN, PINK1, and LRRK2 mutations.Movement disorders : official journal of the Movement Disorder Society, , Apr-15, Volume: 24, Issue:5, 2009
Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease?Movement disorders : official journal of the Movement Disorder Society, , Apr-30, Volume: 24, Issue:6, 2009
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Neuroanatomy and pathology of sporadic Parkinson's disease.Advances in anatomy, embryology, and cell biology, , Volume: 201, 2009
Genotypic and phenotypic characteristics of Dutch patients with early onset Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Jan-30, Volume: 24, Issue:2, 2009
DnaJB6 is present in the core of Lewy bodies and is highly up-regulated in parkinsonian astrocytes.Journal of neuroscience research, , Volume: 87, Issue:1, 2009
A highly reproducible rotenone model of Parkinson's disease.Neurobiology of disease, , Volume: 34, Issue:2, 2009
[Frontier researches for the development of molecular-targeted therapies for familial Parkinson disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 61, Issue:8, 2009
Lipid bilayer disruption by oligomeric alpha-synuclein depends on bilayer charge and accessibility of the hydrophobic core.Biochimica et biophysica acta, , Volume: 1788, Issue:6, 2009
Subchronic infusion of the product of inflammation prostaglandin J2 models sporadic Parkinson's disease in mice.Journal of neuroinflammation, , Jul-25, Volume: 6, 2009
Clinical and pathological characteristics of patients with leucine-rich repeat kinase-2 mutations.Movement disorders : official journal of the Movement Disorder Society, , Jan-15, Volume: 24, Issue:1, 2009
Parkin and PINK1 parkinsonism may represent nigral mitochondrial cytopathies distinct from Lewy body Parkinson's disease.Parkinsonism & related disorders, , Volume: 15, Issue:10, 2009
Striatal neuroinflammation promotes Parkinsonism in rats.PloS one, , Volume: 4, Issue:5, 2009
The association between mutations in the lysosomal protein glucocerebrosidase and parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Aug-15, Volume: 24, Issue:11, 2009
The nigrostriatal pathway in Creutzfeldt-Jakob disease.Journal of neuropathology and experimental neurology, , Volume: 68, Issue:7, 2009
Parkinsonism in hiv-infected patients on highly active antiretroviral therapy.Neurology, , Aug-04, Volume: 73, Issue:5, 2009
Parkinson's disease.Lancet (London, England), , Jun-13, Volume: 373, Issue:9680, 2009
Inhibitors of protein aggregation and toxicity.Biochemical Society transactions, , Volume: 37, Issue:Pt 4, 2009
Protection against paraquat and A53T alpha-synuclein toxicity by cabergoline is partially mediated by dopamine receptors.Journal of the neurological sciences, , Mar-15, Volume: 278, Issue:1-2, 2009
CD4+ T cells mediate cytotoxicity in neurodegenerative diseases.The Journal of clinical investigation, , Volume: 119, Issue:1, 2009
Curvature dynamics of alpha-synuclein familial Parkinson disease mutants: molecular simulations of the micelle- and bilayer-bound forms.The Journal of biological chemistry, , Mar-13, Volume: 284, Issue:11, 2009
Alpha-synuclein gene rearrangements in dominantly inherited parkinsonism: frequency, phenotype, and mechanisms.Archives of neurology, , Volume: 66, Issue:1, 2009
Molecular basis of Parkinson's disease.Neuroreport, , Jan-28, Volume: 20, Issue:2, 2009
Persistent short-term memory defects following sleep deprivation in a drosophila model of Parkinson disease.Sleep, , Volume: 32, Issue:8, 2009
Review: Familial Parkinson's disease--genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease.Neuropathology and applied neurobiology, , Volume: 34, Issue:3, 2008
Mutation analyses in amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula, Japan.Movement disorders : official journal of the Movement Disorder Society, , Dec-15, Volume: 23, Issue:16, 2008
Second consensus statement on the diagnosis of multiple system atrophy.Neurology, , Aug-26, Volume: 71, Issue:9, 2008
Value of genetic models in understanding the cause and mechanisms of Parkinson's disease.Current neurology and neuroscience reports, , Volume: 8, Issue:4, 2008
Enduring involvement of tau, beta-amyloid, alpha-synuclein, ubiquitin and TDP-43 pathology in the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam (ALS/PDC).Acta neuropathologica, , Volume: 116, Issue:6, 2008
High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in a Drosophila model of Parkinson's disease.Journal of neuroscience research, , Volume: 86, Issue:9, 2008
Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementia.Archives of neurology, , Volume: 65, Issue:4, 2008
alpha-Synuclein and its disease-related mutants interact differentially with the microtubule protein tau and associate with the actin cytoskeleton.Neurobiology of disease, , Volume: 26, Issue:3, 2007
Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.Journal of neurochemistry, , Volume: 101, Issue:6, 2007
Expanding insights on the involvement of endoplasmic reticulum stress in Parkinson's disease.Antioxidants & redox signaling, , Volume: 9, Issue:5, 2007
Quantitative proteomics identifies surfactant-resistant alpha-synuclein in cerebral cortex of Parkinsonism-dementia complex of Guam but not Alzheimer's disease or progressive supranuclear palsy.The American journal of pathology, , Volume: 171, Issue:3, 2007
Animal models in neurodegenerative diseases.Journal of neural transmission. Supplementum, , Issue:72, 2007
Clinical genetics of Parkinson's disease and related disorders.Parkinsonism & related disorders, , Volume: 13 Suppl 3, 2007
Analysis of alpha-synuclein, dopamine and parkin pathways in neuropathologically confirmed parkinsonian nigra.Acta neuropathologica, , Volume: 113, Issue:3, 2007
Screening for SNCA and LRRK2 mutations in Greek sporadic and autosomal dominant Parkinson's disease: identification of two novel LRRK2 variants.European journal of neurology, , Volume: 14, Issue:1, 2007
Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication.Neurology, , Mar-20, Volume: 68, Issue:12, 2007
[Animal models of neurodegenerative diseases].Medecine sciences : M/S, , Volume: 23, Issue:2, 2007
14-3-3eta is a novel regulator of parkin ubiquitin ligase.The EMBO journal, , Jan-11, Volume: 25, Issue:1, 2006
Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system.Neurobiology of disease, , Volume: 22, Issue:2, 2006
Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Sep-27, Volume: 26, Issue:39, 2006
Behavioral phenotypes and pharmacology in genetic mouse models of Parkinsonism.Behavioural pharmacology, , Volume: 17, Issue:5-6, 2006
Parkinsonism genes: culprits and clues.Journal of neurochemistry, , Volume: 99, Issue:4, 2006
Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models.Science (New York, N.Y.), , Jul-21, Volume: 313, Issue:5785, 2006
Transduced Tat-alpha-synuclein protects against oxidative stress in vitro and in vivo.Journal of biochemistry and molecular biology, , May-31, Volume: 39, Issue:3, 2006
Dementia with Lewy bodies in an elderly Greek male due to alpha-synuclein gene mutation.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, , Volume: 13, Issue:9, 2006
Mice lacking alpha-synuclein are resistant to mitochondrial toxins.Neurobiology of disease, , Volume: 21, Issue:3, 2006
Parkinsonism, Lrrk2 G2019S, and tau neuropathology.Neurology, , Oct-24, Volume: 67, Issue:8, 2006
Genetics of Parkinson's disease and parkinsonism.Annals of neurology, , Volume: 60, Issue:4, 2006
Role of DJ-1 in Parkinson's disease.Journal of molecular neuroscience : MN, , Volume: 29, Issue:3, 2006
Convergent roles of alpha-synuclein, DA metabolism, and the ubiquitin-proteasome system in nigrostriatal toxicity.Annals of the New York Academy of Sciences, , Volume: 1074, 2006
Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-15, Volume: 26, Issue:46, 2006
Alpha-synuclein expression in the substantia nigra of MPTP-lesioned non-human primates.Neurobiology of disease, , Volume: 20, Issue:3, 2005
Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and drug-induced rotational asymmetry in hemi-parkinsonian rats.Journal of neurochemistry, , Volume: 95, Issue:4, 2005
Abnormal sleep architecture is an early feature in the E46K familial synucleinopathy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20, Issue:10, 2005
Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human alpha-synuclein.Neurobiology of disease, , Volume: 20, Issue:2, 2005
In vivo models of multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
Atypical parkinsonism combining alpha-synuclein inclusions and polyglucosan body disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20, Issue:2, 2005
The pathology of the substantia nigra in Alzheimer disease with extrapyramidal signs.Neurology, , Apr-26, Volume: 64, Issue:8, 2005
Marmoset monkey models of Parkinson's disease: which model, when and why?Brain research bulletin, , Dec-30, Volume: 68, Issue:3, 2005
Viral vector mediated overexpression of human alpha-synuclein in the nigrostriatal dopaminergic neurons: a new model for Parkinson's disease.CNS spectrums, , Volume: 10, Issue:3, 2005
Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , Mar-01, Volume: 102, Issue:9, 2005
Unaltered alpha-synuclein blood levels in juvenile Parkinsonism with a parkin exon 4 deletion.Neuroscience letters, , Feb-21, Volume: 374, Issue:3, 2005
Familial mutants of alpha-synuclein with increased neurotoxicity have a destabilized conformation.The Journal of biological chemistry, , Sep-02, Volume: 280, Issue:35, 2005
Iron and alpha-synuclein in the substantia nigra of MPTP-treated mice: effect of neuroprotective drugs R-apomorphine and green tea polyphenol (-)-epigallocatechin-3-gallate.Journal of molecular neuroscience : MN, , Volume: 24, Issue:3, 2004
Occurrence of alpha-synuclein pathology in the cerebellum of Guamanian patients with parkinsonism-dementia complex.Acta neuropathologica, , Volume: 107, Issue:6, 2004
Alpha-synuclein missense and multiplication mutations in autosomal dominant Parkinson's disease.Neuroscience letters, , Aug-26, Volume: 367, Issue:1, 2004
Axonal transport of human alpha-synuclein slows with aging but is not affected by familial Parkinson's disease-linked mutations.Journal of neurochemistry, , Volume: 88, Issue:2, 2004
Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications.Annals of neurology, , Volume: 55, Issue:2, 2004
[Analysis of alpha-synuclein and its significance].Nihon rinsho. Japanese journal of clinical medicine, , Volume: 62, Issue:9, 2004
An overview of parkinsonian syndromes: data from the literature and from an Italian data-base.Sleep medicine, , Volume: 5, Issue:2, 2004
Parkin-positive autosomal recessive juvenile Parkinsonism with alpha-synuclein-positive inclusions.Neurology, , Aug-24, Volume: 63, Issue:4, 2004
Phosphorylated alpha-synuclein in normal mouse brain.FEBS letters, , Aug-13, Volume: 572, Issue:1-3, 2004
Abnormal alpha-synuclein interactions with Rab proteins in alpha-synuclein A30P transgenic mice.Journal of neuropathology and experimental neurology, , Volume: 63, Issue:4, 2004
Gaucher disease associated with parkinsonism: four further case reports.American journal of medical genetics. Part A, , Feb-01, Volume: 116A, Issue:4, 2003
Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.Experimental neurology, , Volume: 179, Issue:1, 2003
Familial Parkinson's disease: a hint to elucidate the mechanisms of nigral degeneration.Journal of neurology, , Volume: 250 Suppl 3, 2003
Molecular pathways of neurodegeneration in Parkinson's disease.Science (New York, N.Y.), , Oct-31, Volume: 302, Issue:5646, 2003
Multiple system atrophy: an update.Movement disorders : official journal of the Movement Disorder Society, , Volume: 18 Suppl 6, 2003
Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism.Neurology, , Jul-08, Volume: 61, Issue:1, 2003
Parkinson's disease and related alpha-synucleinopathies are brain amyloidoses.Annals of the New York Academy of Sciences, , Volume: 991, 2003
Alpha-synuclein up-regulates expression of caveolin-1 and down-regulates extracellular signal-regulated kinase activity in B103 neuroblastoma cells: role in the pathogenesis of Parkinson's disease.Journal of neurochemistry, , Volume: 85, Issue:6, 2003
[Recent neuropathology of parkinsonian syndromes].Revue neurologique, , Volume: 159, Issue:5 Pt 2, 2003
Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice.Neuroscience, , Volume: 118, Issue:4, 2003
Alpha-synuclein overexpression protects against paraquat-induced neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Apr-15, Volume: 23, Issue:8, 2003
A broken alpha -helix in folded alpha -Synuclein.The Journal of biological chemistry, , Apr-25, Volume: 278, Issue:17, 2003
Genetics of parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Volume: 17, Issue:4, 2002
[alpha-synuclein and Parkinson's disease].Seikagaku. The Journal of Japanese Biochemical Society, , Volume: 74, Issue:6, 2002
Molecular findings in familial Parkinson disease in Spain.Archives of neurology, , Volume: 59, Issue:6, 2002
Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam.The American journal of pathology, , Volume: 160, Issue:5, 2002
Familial diffuse Lewy body disease, eye movement abnormalities, and distribution of pathology.Archives of neurology, , Volume: 59, Issue:3, 2002
Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease.Science (New York, N.Y.), , Feb-01, Volume: 295, Issue:5556, 2002
Familial Parkinson's disease. Alpha-synuclein and parkin.Advances in neurology, , Volume: 86, 2001
Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult.Journal of neurochemistry, , Volume: 76, Issue:4, 2001
Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease.Journal of neurochemistry, , Volume: 76, Issue:2, 2001
Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr alpha-synuclein mutation.Annals of neurology, , Volume: 49, Issue:3, 2001
Experimental models of Parkinson's disease.Nature reviews. Neuroscience, , Volume: 2, Issue:5, 2001
Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice.Journal of neurochemistry, , Volume: 77, Issue:4, 2001
Familial parkinsonism with synuclein pathology: clinical and PET studies of A30P mutation carriers.Neurology, , May-22, Volume: 56, Issue:10, 2001
Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease.Science (New York, N.Y.), , Jul-13, Volume: 293, Issue:5528, 2001
Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter.Neurobiology of disease, , Volume: 8, Issue:3, 2001
Analysis of alpha-synuclein, parkin, tau, and UCH-L1 in a Japanese family with autosomal dominant parkinsonism.European neurology, , Volume: 46, Issue:1, 2001
Alpha-synuclein inclusions in amygdala in the brains of patients with the parkinsonism-dementia complex of Guam.Journal of neuropathology and experimental neurology, , Volume: 59, Issue:7, 2000
Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP.Journal of neurochemistry, , Volume: 74, Issue:2, 2000
Importance of familial Parkinson's disease and parkinsonism to the understanding of nigral degeneration in sporadic Parkinson's disease.Journal of neural transmission. Supplementum, , Issue:60, 2000
Progress in the clinical and molecular genetics of familial parkinsonism.Neurogenetics, , Volume: 2, Issue:4, 2000
Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex.Journal of neurochemistry, , Volume: 75, Issue:5, 2000
Lack of alpha-synuclein gene mutations in families with autosomal dominant Parkinson's disease in Russia.Journal of neurology, , Volume: 247, Issue:12, 2000
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The genetics of disorders with synuclein pathology and parkinsonism.Human molecular genetics, , Volume: 8, Issue:10, 1999
A macrophage-nanozyme delivery system for Parkinson's disease.Bioconjugate chemistry, , Volume: 18, Issue:5
Overexpression of Parkinson's Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology.eNeuro, , Volume: 4, Issue:2
alpha-synuclein and Parkinson's disease: the first roadblock.Journal of cellular and molecular medicine, , Volume: 10, Issue:4
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Possible Role of the Polyglutamine Elongation in Evolution of Amyloid-Related Evolvability.Journal of Huntington's disease, , Volume: 7, Issue:4, 2018
Abnormal Paraplegin Expression in Swollen Neurites, τ- and α-Synuclein Pathology in a Case of Hereditary Spastic Paraplegia SPG7 with an Ala510Val Mutation.International journal of molecular sciences, , Oct-21, Volume: 16, Issue:10, 2015
Cerebrospinal Fluid Biomarkers in Spinocerebellar Ataxia: A Pilot Study.Disease markers, , Volume: 2015, 2015
Cerebrospinal fluid from patients with multiple system atrophy promotes in vitro α-synuclein fibril formation.Neuroscience letters, , Mar-10, Volume: 491, Issue:1, 2011
Multiple system atrophy in a patient with the spinocerebellar ataxia 3 gene mutation.Movement disorders : official journal of the Movement Disorder Society, , Jan-15, Volume: 22, Issue:2, 2007
Anticipation of onset age in familial Parkinson's disease without SCA gene mutations.Parkinsonism & related disorders, , Volume: 12, Issue:5, 2006
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A review on the cause-effect relationship between oxidative stress and toxic proteins in the pathogenesis of neurodegenerative diseases.Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, , Volume: 118, Issue:1
Psychiatric symptoms of frontotemporal dementia and subcortical (co-)pathology burden: new insights.Brain : a journal of neurology, , 01-05, Volume: 146, Issue:1, 2023
Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions.Acta neuropathologica communications, , 07-21, Volume: 9, Issue:1, 2021
Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated.Brain : a journal of neurology, , 07-01, Volume: 141, Issue:7, 2018
A Novel Tau Mutation in Exon 12, p.Q336H, Causes Hereditary Pick Disease.Journal of neuropathology and experimental neurology, , Volume: 74, Issue:11, 2015
[Molecular neuropathology of Non-Alzheimer dementia].Der Pathologe, , Volume: 29, Issue:6, 2008
A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology.Brain : a journal of neurology, , Volume: 130, Issue:Pt 5, 2007
Phosphorylated Smad 2/3 colocalizes with phospho-tau inclusions in Pick disease, progressive supranuclear palsy, and corticobasal degeneration but not with alpha-synuclein inclusions in multiple system atrophy or dementia with Lewy bodies.Journal of neuropathology and experimental neurology, , Volume: 66, Issue:11, 2007
Abnormal alpha-synuclein solubility, aggregation and nitration in the frontal cortex in Pick's disease.Neuroscience letters, , May-29, Volume: 400, Issue:1-2, 2006
Identification of G-protein coupled receptor kinase 2 in paired helical filaments and neurofibrillary tangles.Journal of neuropathology and experimental neurology, , Volume: 65, Issue:12, 2006
[Nosology of dementias: the neuropathologist's point of view].Revue neurologique, , Volume: 162, Issue:10, 2006
Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease.Acta neuropathologica, , Volume: 107, Issue:6, 2004
Pick's disease: alpha- and beta-synuclein-immunoreactive Pick bodies in the dentate gyrus.Acta neuropathologica, , Volume: 104, Issue:5, 2002
Clusterin/apolipoprotein J is associated with cortical Lewy bodies: immunohistochemical study in cases with alpha-synucleinopathies.Acta neuropathologica, , Volume: 104, Issue:3, 2002
Stains for the differential diagnosis of degenerative dementias.Biotechnic & histochemistry : official publication of the Biological Stain Commission, , Volume: 74, Issue:6, 1999
A review on the cause-effect relationship between oxidative stress and toxic proteins in the pathogenesis of neurodegenerative diseases.Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, , Volume: 118, Issue:1
Cross-sectional associations of cerebrospinal α-synuclein, tau and amyloid-β with dyskinesias, motor fluctuations, non-motor symptoms in a cohort of Parkinson's disease patients.Journal of the neurological sciences, , Nov-15, Volume: 430, 2021
Integrated Plasma and Neuroimaging Biomarkers Associated with Motor and Cognition Severity in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 10, Issue:1, 2020
Propagated α-synucleinopathy recapitulates REM sleep behaviour disorder followed by parkinsonian phenotypes in mice.Brain : a journal of neurology, , 12-05, Volume: 143, Issue:11, 2020
[Current Status and Future Prospects of Therapeutic Development of Parkinson's Disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:1, 2020
DL‑3‑n‑butylphthalide reduces microglial activation in lipopolysaccharide‑induced Parkinson's disease model mice.Molecular medicine reports, , Volume: 17, Issue:3, 2018
The nonmotor features of Parkinson's disease: pathophysiology and management advances.Current opinion in neurology, , Volume: 29, Issue:4, 2016
A Genetic Mouse Model of Parkinson's Disease Shows Involuntary Movements and Increased Postsynaptic Sensitivity to Apomorphine.Molecular neurobiology, , Volume: 52, Issue:3, 2015
Juvenile parkinsonism: Differential diagnosis, genetics, and treatment.Parkinsonism & related disorders, , Volume: 67, 2019
Unusual α-synuclein and cerebellar pathologies in a case of hereditary myoclonus-dystonia without SGCE mutation.Neuropathology and applied neurobiology, , Volume: 41, Issue:6, 2015
Widespread Lewy body and tau accumulation in childhood and adult onset dystonia-parkinsonism cases with PLA2G6 mutations.Neurobiology of aging, , Volume: 33, Issue:4, 2012
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'Under pressure': is there a link between orthostatic hypotension and cognitive impairment in α-synucleinopathies?Journal of neurology, neurosurgery, and psychiatry, , Volume: 87, Issue:12, 2016
Loss of PINK1 inhibits apoptosis by upregulating α-synuclein in inflammation-sensitized hypoxic-ischemic injury in the immature brains.Brain research, , 12-15, Volume: 1653, 2016
Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:10, 2022
Progressive striatonigral degeneration in a transgenic mouse model of multiple system atrophy: translational implications for interventional therapies.Acta neuropathologica communications, , 01-03, Volume: 6, Issue:1, 2018
Mitochondrial division inhibitor-1 is neuroprotective in the A53T-α-synuclein rat model of Parkinson's disease.Scientific reports, , 08-08, Volume: 7, Issue:1, 2017
Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression.Acta neuropathologica communications, , Jul-25, Volume: 3, 2015
Spatial patterns of alpha-synuclein positive glial cytoplasmic inclusions in multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 19, Issue:1, 2004
Patterns of protein nitration in dementia with Lewy bodies and striatonigral degeneration.Acta neuropathologica, , Volume: 103, Issue:5, 2002
MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons.Neuroreport, , Jan-17, Volume: 11, Issue:1, 2000
Neuronal SNCA transcription during Lewy body formation.Acta neuropathologica communications, , 11-23, Volume: 11, Issue:1, 2023
[no title available]Biomolecular NMR assignments, , Volume: 17, Issue:2, 2023
Evaluation of N- and O-Linked Indole Triazines for a Dual Effect on α-Synuclein and Tau Aggregation.ACS chemical neuroscience, , 11-01, Volume: 14, Issue:21, 2023
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Misfolded α-Synuclein in Cerebrospinal Fluid of Contact Sport Athletes.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:11, 2023
Viral-like TLR3 induction of cytokine networks and α-synuclein are reduced by complement C3 blockade in mouse brain.Scientific reports, , 09-13, Volume: 13, Issue:1, 2023
α-Synuclein Strains and Their Relevance to Parkinson's Disease, Multiple System Atrophy, and Dementia with Lewy Bodies.International journal of molecular sciences, , Jul-28, Volume: 24, Issue:15, 2023
Investigation of Inflammation in Lewy Body Dementia: A Systematic Scoping Review.International journal of molecular sciences, , Jul-28, Volume: 24, Issue:15, 2023
The variance in phosphorylated, insoluble ⍺-synuclein in humans, rats, and mice is not mainly driven by biological sex.Acta neuropathologica, , Volume: 146, Issue:4, 2023
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Cognitive effects of Lewy body pathology in clinically unimpaired individuals.Nature medicine, , Volume: 29, Issue:8, 2023
Decreased DHA-containing phospholipids in the neocortex of dementia with Lewy bodies are associated with soluble AβBrain pathology (Zurich, Switzerland), , Volume: 33, Issue:6, 2023
More than meets the eye in Parkinson's disease and other synucleinopathies: from proteinopathy to lipidopathy.Acta neuropathologica, , Volume: 146, Issue:3, 2023
Clinical trials in dementia with Lewy bodies: the evolving concept of co-pathologies, patient selection and biomarkers.Current opinion in neurology, , 08-01, Volume: 36, Issue:4, 2023
The Mechanisms of the Roles of α-Synuclein, Amyloid-β, and Tau Protein in the Lewy Body Diseases: Pathogenesis, Early Detection, and Therapeutics.International journal of molecular sciences, , Jun-17, Volume: 24, Issue:12, 2023
Disease-Specific α-Synuclein Seeding in Lewy Body Disease and Multiple System Atrophy Are Preserved in Formaldehyde-Fixed Paraffin-Embedded Human Brain.Biomolecules, , 06-02, Volume: 13, Issue:6, 2023
Nigral Pathology Contributes to Microstructural Integrity of Striatal and Frontal Tracts in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:9, 2023
A 14-day pulse of PLX5622 modifies α-synucleinopathy in preformed fibril-infused aged mice of both sexes.Neurobiology of disease, , Volume: 184, 2023
Cellular processing of α-synuclein fibrils results in distinct physiological C-terminal truncations with a major cleavage site at residue Glu 114.The Journal of biological chemistry, , Volume: 299, Issue:7, 2023
Propagative α-synuclein seeds as serum biomarkers for synucleinopathies.Nature medicine, , Volume: 29, Issue:6, 2023
Parkinson's disease in a patient with olfactory hypoplasia: a model case of "body-first Lewy body disease" providing insights into the progression of α-synuclein accumulation.Journal of neurology, , Volume: 270, Issue:10, 2023
Neuropathology of incidental Lewy body & prodromal Parkinson's disease.Molecular neurodegeneration, , 05-12, Volume: 18, Issue:1, 2023
Proposal for a Biologic Staging System of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 13, Issue:3, 2023
The brain-first vs. body-first model of Parkinson's disease with comparison to alternative models.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 130, Issue:6, 2023
Sigma-2 Receptors-From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases.International journal of molecular sciences, , Mar-26, Volume: 24, Issue:7, 2023
Plasma GFAP associates with secondary Alzheimer's pathology in Lewy body disease.Annals of clinical and translational neurology, , Volume: 10, Issue:5, 2023
Serotonin in synucleinopathies.Behavioural brain research, , 05-08, Volume: 445, 2023
Biomarkers of diagnosis, prognosis, pathogenesis, response to therapy: Convergence or divergence? Lessons from Alzheimer's disease and synucleinopathies.Handbook of clinical neurology, , Volume: 192, 2023
[no title available]ACS chemical neuroscience, , 03-01, Volume: 14, Issue:5, 2023
On the Track of α-Synuclein in the Body: Skin Biopsies for Diagnosing Synucleinopathies?Neurology, , 04-11, Volume: 100, Issue:15, 2023
Lifelong constipation in Parkinson's disease and other clinically defined alpha-synucleinopathies: A population-based study in Southeast Minnesota.Parkinsonism & related disorders, , Volume: 107, 2023
Implications of DNA Methylation in Lewy Body Pathology.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:1, 2023
Cross-sectional Associations of β-Amyloid, Tau, and Cerebrovascular Biomarkers With Neurodegeneration in Probable Dementia With Lewy Bodies.Neurology, , 02-21, Volume: 100, Issue:8, 2023
Identification of Novel α-Synuclein Assemblies in Lewy Body Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:1, 2023
Microbiome-gut-brain dysfunction in prodromal and symptomatic Lewy body diseases.Journal of neurology, , Volume: 270, Issue:2, 2023
Phosphorylated α-synuclein in skin Schwann cells: a new biomarker for multiple system atrophy.Brain : a journal of neurology, , 03-01, Volume: 146, Issue:3, 2023
Seed amplification and RT-QuIC assays to investigate protein seed structures and strains.Cell and tissue research, , Volume: 392, Issue:1, 2023
Aggregated Alpha-Synuclein Inclusions within the Nucleus Predict Impending Neuronal Cell Death in a Mouse Model of Parkinsonism.International journal of molecular sciences, , Dec-04, Volume: 23, Issue:23, 2022
Axonal degeneration in the anterior insular cortex is associated with Alzheimer's co-pathology in Parkinson's disease and dementia with Lewy bodies.Translational neurodegeneration, , 12-07, Volume: 11, Issue:1, 2022
The Proteome of Neuromelanin Granules in Dementia with Lewy Bodies.Cells, , 11-09, Volume: 11, Issue:22, 2022
Intracellular Accumulation of α-Synuclein Aggregates Promotes S-Nitrosylation of MAP1A Leading to Decreased NMDAR-Evoked Calcium Influx and Loss of Mature Synaptic Spines.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 12-14, Volume: 42, Issue:50, 2022
Human pericytes degrade diverse α-synuclein aggregates.PloS one, , Volume: 17, Issue:11, 2022
Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders.Acta neuropathologica communications, , 11-12, Volume: 10, Issue:1, 2022
Cerebrospinal Fluid Alpha-Synuclein Improves the Differentiation between Dementia with Lewy Bodies and Alzheimer's Disease in Clinical Practice.International journal of molecular sciences, , Nov-04, Volume: 23, Issue:21, 2022
Inhibition of α-Synuclein Seeding-Dependent Aggregation by ssDNA Aptamers Specific to C-Terminally Truncated α-Synuclein Fibrils.ACS chemical neuroscience, , 12-07, Volume: 13, Issue:23, 2022
[Development of therapeutic peptides for Lewy body diseases preventing α-synuclein propagation].Nihon yakurigaku zasshi. Folia pharmacologica Japonica, , Volume: 157, Issue:6, 2022
[Role of fatty acid-binding protein 7 and novel therapeutic approach in synucleinopathies].Nihon yakurigaku zasshi. Folia pharmacologica Japonica, , Volume: 157, Issue:6, 2022
Diagnostic value of α-synuclein seeding amplification assays in α-synucleinopathies: A systematic review and meta-analysis.Parkinsonism & related disorders, , Volume: 104, 2022
Development of an α-synuclein fibril and oligomer specific tracer for diagnosis of Parkinson's disease, dementia with Lewy bodies and multiple system atrophy.Neurochemistry international, , Volume: 161, 2022
Diagnosis and Treatment of Cognitive and Neuropsychiatric Symptoms in Parkinson Disease and Dementia With Lewy Bodies.Continuum (Minneapolis, Minn.), , Oct-01, Volume: 28, Issue:5, 2022
Structures of α-synuclein filaments from human brains with Lewy pathology.Nature, , Volume: 610, Issue:7933, 2022
Exploring the link between GBA1 mutations and Dementia with Lewy bodies, A mini-review.Neuroscience and biobehavioral reviews, , Volume: 141, 2022
Perception of Fragmented Letters by Patients With Pathologically Confirmed Dementia With Lewy Bodies or Alzheimer Disease.Neurology, , 11-01, Volume: 99, Issue:18, 2022
Synucleinopathy in Amyotrophic Lateral Sclerosis: A Potential Avenue for Antisense Therapeutics?International journal of molecular sciences, , Aug-19, Volume: 23, Issue:16, 2022
Threonine Cavities Are Targetable Motifs That Control Alpha-Synuclein Fibril Growth.ACS chemical neuroscience, , 09-07, Volume: 13, Issue:17, 2022
Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology.Nature communications, , 08-22, Volume: 13, Issue:1, 2022
Lewy Body Disease Primate Model with α-Synuclein Propagation from the Olfactory Bulb.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:10, 2022
Natural speech markers of Alzheimer's disease co-pathology in Lewy body dementias.Parkinsonism & related disorders, , Volume: 102, 2022
Norovirus Intestinal Infection and Lewy Body Disease in an Older Patient with Acute Cognitive Impairment.International journal of molecular sciences, , Jul-29, Volume: 23, Issue:15, 2022
Alteration of Vesicle-Associated Membrane Protein-Binding Protein B in α-Synuclein Aggregates in Lewy Body Disease.Journal of neuropathology and experimental neurology, , 09-19, Volume: 81, Issue:10, 2022
Amitriptyline improves cognitive and neuronal function in a rat model that mimics dementia with lewy bodies.Behavioural brain research, , 10-28, Volume: 435, 2022
Involvement of autophagic protein DEF8 in Lewy bodies.Biochemical and biophysical research communications, , 10-01, Volume: 623, 2022
α-Synuclein Seed Amplification Assays for Diagnosing Synucleinopathies: The Way Forward.Neurology, , 08-02, Volume: 99, Issue:5, 2022
Parkinson's Disease Etiology: Insights and Associations with Phosphate Toxicity.International journal of molecular sciences, , Jul-22, Volume: 23, Issue:15, 2022
Recent advances in establishing fluid biomarkers for the diagnosis and differentiation of alpha-synucleinopathies - a mini review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 32, Issue:4, 2022
A versatile fluorescence-quenched substrate for quantitative measurement of glucocerebrosidase activity within live cells.Proceedings of the National Academy of Sciences of the United States of America, , 07-19, Volume: 119, Issue:29, 2022
α-Synuclein fibril-specific nanobody reduces prion-like α-synuclein spreading in mice.Nature communications, , 07-19, Volume: 13, Issue:1, 2022
Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies.Acta neuropathologica communications, , 07-06, Volume: 10, Issue:1, 2022
α-Synuclein molecular behavior and nigral proteomic profiling distinguish subtypes of Lewy body disorders.Acta neuropathologica, , Volume: 144, Issue:2, 2022
Performance of αSynuclein RT-QuIC in relation to neuropathological staging of Lewy body disease.Acta neuropathologica communications, , 06-22, Volume: 10, Issue:1, 2022
α-synucleinopathy exerts sex-dimorphic effects on the multipurpose DNA repair/redox protein APE1 in mice and humans.Progress in neurobiology, , Volume: 216, 2022
Immunogenicity of MultiTEP-Platform-Based Recombinant Protein Vaccine, PV-1950R, Targeting Three B-Cell Antigenic Determinants of Pathological α-Synuclein.International journal of molecular sciences, , May-29, Volume: 23, Issue:11, 2022
Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies.Acta neuropathologica communications, , 06-03, Volume: 10, Issue:1, 2022
The promise of amplification assays for accurate early detection of α-synucleinopathies: A review.Experimental gerontology, , Volume: 165, 2022
A case series of cutaneous phosphorylated α-synuclein in Long-COVID POTS.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 32, Issue:3, 2022
MCC950 ameliorates the dementia symptom at the early age of line M83 mouse and reduces hippocampal α-synuclein accumulation.Biochemical and biophysical research communications, , 06-30, Volume: 611, 2022
APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer's disease with Lewy body pathology.Acta neuropathologica, , Volume: 143, Issue:6, 2022
Gastrointestinal Biopsy Obtained During Cancer Screening, a Biological Marker for α-Synucleinopathy?Journal of neuropathology and experimental neurology, , 04-27, Volume: 81, Issue:5, 2022
Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups.Brain : a journal of neurology, , 06-03, Volume: 145, Issue:5, 2022
α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity.Proceedings of the National Academy of Sciences of the United States of America, , 04-12, Volume: 119, Issue:15, 2022
Leukotriene Signaling as a Target in α-Synucleinopathies.Biomolecules, , 02-23, Volume: 12, Issue:3, 2022
Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies.Acta neuropathologica communications, , 03-16, Volume: 10, Issue:1, 2022
Brain injections of glial cytoplasmic inclusions induce a multiple system atrophy-like pathology.Brain : a journal of neurology, , 04-29, Volume: 145, Issue:3, 2022
Cardiac Alpha-Synuclein Is Present in Alpha-Synucleinopathies.Journal of Parkinson's disease, , Volume: 12, Issue:4, 2022
[Autonomic Dysfunction in Lewy Body Disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 74, Issue:3, 2022
Unique Lewy pathology in myotonic dystrophy type 1.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 42, Issue:2, 2022
S-Nitrosylation of p62 Inhibits Autophagic Flux to Promote α-Synuclein Secretion and Spread in Parkinson's Disease and Lewy Body Dementia.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 04-06, Volume: 42, Issue:14, 2022
Current Progress in the Development of Probes for Targeting α-Synuclein Aggregates.ACS chemical neuroscience, , 03-02, Volume: 13, Issue:5, 2022
Fluid markers of synapse degeneration in synucleinopathies.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 129, Issue:2, 2022
Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations.Acta neuropathologica, , Volume: 143, Issue:4, 2022
Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy.Proceedings of the National Academy of Sciences of the United States of America, , 02-08, Volume: 119, Issue:6, 2022
Impaired Sphingolipid Hydrolase Activities in Dementia with Lewy Bodies and Multiple System Atrophy.Molecular neurobiology, , Volume: 59, Issue:4, 2022
Quantifying regional α -synuclein, amyloid β, and tau accumulation in lewy body dementia.Annals of clinical and translational neurology, , Volume: 9, Issue:2, 2022
Infectious Agents as Potential Drivers of α-Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:3, 2022
Differentiating dementia with Lewy bodies from Alzheimer's disease and Parkinson's disease dementia: an update on imaging modalities.Journal of neurology, , Volume: 269, Issue:2, 2022
Prion-like α-synuclein pathology in the brain of infants with Krabbe disease.Brain : a journal of neurology, , 05-24, Volume: 145, Issue:4, 2022
Elevated norepinephrine may interact with alpha-synuclein to promote Parkinson's disease and DLB.Acta neurologica Scandinavica, , Volume: 145, Issue:1, 2022
The role of cardiovascular autonomic failure in the differential diagnosis of α-synucleinopathies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 43, Issue:1, 2022
Pathology-associated change in levels and localization of SIDT2 in postmortem brains of Parkinson's disease and dementia with Lewy bodies patients.Neurochemistry international, , Volume: 152, 2022
Lewy pathology of the esophagus correlates with the progression of Lewy body disease: a Japanese cohort study of autopsy cases.Acta neuropathologica, , Volume: 141, Issue:1, 2021
Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies.Acta neuropathologica communications, , 08-28, Volume: 9, Issue:1, 2021
Nasal Rifampicin Improves Cognition in a Mouse Model of Dementia with Lewy Bodies by Reducing α-Synuclein Oligomers.International journal of molecular sciences, , Aug-06, Volume: 22, Issue:16, 2021
A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies.Acta neuropathologica, , Volume: 142, Issue:3, 2021
Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions.Acta neuropathologica communications, , 07-21, Volume: 9, Issue:1, 2021
Lewy bodies in the olfactory system and the hypothalamus.Handbook of clinical neurology, , Volume: 182, 2021
Diagnostic Value of the CSF α-Synuclein Real-Time Quaking-Induced Conversion Assay at the Prodromal MCI Stage of Dementia With Lewy Bodies.Neurology, , 08-31, Volume: 97, Issue:9, 2021
CSF Protein Level of Neurotransmitter Secretion, Synaptic Plasticity, and Autophagy in PD and DLB.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:11, 2021
Vagus Nerve and Stomach Synucleinopathy in Parkinson's Disease, Incidental Lewy Body Disease, and Normal Elderly Subjects: Evidence Against the "Body-First" Hypothesis.Journal of Parkinson's disease, , Volume: 11, Issue:4, 2021
Human amyloid beta and α-synuclein co-expression in neurons impair behavior and recapitulate features for Lewy body dementia in Caenorhabditis elegans.Biochimica et biophysica acta. Molecular basis of disease, , 10-01, Volume: 1867, Issue:10, 2021
Complicity of α-synuclein oligomer and calcium dyshomeostasis in selective neuronal vulnerability in Lewy body disease.Archives of pharmacal research, , Volume: 44, Issue:6, 2021
RT-QuIC Using C-Terminally Truncated α-Synuclein Forms Detects Differences in Seeding Propensity of Different Brain Regions from Synucleinopathies.Biomolecules, , 05-31, Volume: 11, Issue:6, 2021
Insights into Lewy body disease from rare neurometabolic disorders.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 128, Issue:10, 2021
Cerebrospinal fluid α synuclein concentrations in patients with positive AD biomarkers and extrapyramidal symptoms.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 128, Issue:6, 2021
RT-QuIC Detection of Pathological α-Synuclein in Skin Punches of Patients with Lewy Body Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:9, 2021
Faster disease progression in Parkinson's disease with type 2 diabetes is not associated with increased α-synuclein, tau, amyloid-β or vascular pathology.Neuropathology and applied neurobiology, , Volume: 47, Issue:7, 2021
Dysfunction of RAB39B-Mediated Vesicular Trafficking in Lewy Body Diseases.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:8, 2021
Associations of Neuropsychiatric Features with Cerebrospinal Fluid Biomarkers of Amyloidogenesis and Neurodegeneration in Dementia with Lewy Bodies Compared with Alzheimer's Disease and Cognitively Healthy People.Journal of Alzheimer's disease : JAD, , Volume: 81, Issue:3, 2021
Phytochemicals as Regulators of Genes Involved in Synucleinopathies.Biomolecules, , 04-22, Volume: 11, Issue:5, 2021
Consistent skin α-synuclein positivity in REM sleep behavior disorder - A two center two-to-four-year follow-up study.Parkinsonism & related disorders, , Volume: 86, 2021
Alpha-Synuclein Oligomers and Neurofilament Light Chain Predict Phenoconversion of Pure Autonomic Failure.Annals of neurology, , Volume: 89, Issue:6, 2021
Molecular Factors Mediating Neural Cell Plasticity Changes in Dementia Brain Diseases.Neural plasticity, , Volume: 2021, 2021
In Vivo Diagnosis of Synucleinopathies: A Comparative Study of Skin Biopsy and RT-QuIC.Neurology, , 05-18, Volume: 96, Issue:20, 2021
Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson's disease and dementia with Lewy bodies.Acta neuropathologica communications, , 04-07, Volume: 9, Issue:1, 2021
Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson's disease.Acta neuropathologica communications, , 03-20, Volume: 9, Issue:1, 2021
Multiple Neurodegenerative Pathologies in an Alzheimer's Disease Patient Treated with Fornical Deep Brain Stimulation.Journal of Alzheimer's disease : JAD, , Volume: 80, Issue:4, 2021
Heterogeneity in α-synuclein fibril activity correlates to disease phenotypes in Lewy body dementia.Acta neuropathologica, , Volume: 141, Issue:4, 2021
Targeted de-repression of neuronal Nrf2 inhibits α-synuclein accumulation.Cell death & disease, , 02-26, Volume: 12, Issue:2, 2021
Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study.The Lancet. Neurology, , Volume: 20, Issue:3, 2021
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture.Nature genetics, , Volume: 53, Issue:3, 2021
Immunohistochemical Detection of Synuclein Pathology in Skin in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:4, 2021
α-Synuclein Heteromers in Red Blood Cells of Alzheimer's Disease and Lewy Body Dementia Patients.Journal of Alzheimer's disease : JAD, , Volume: 80, Issue:2, 2021
Significant Overlap of α-Synuclein, Amyloid-β, and Phospho-Tau Pathologies in Neuropathological Diagnosis of Lewy-related Pathology: Evidence from China Human Brain Bank.Journal of Alzheimer's disease : JAD, , Volume: 80, Issue:1, 2021
Alpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a Parkinson's disease patient (PARK4) with SNCA triplication.FEBS open bio, , Volume: 11, Issue:2, 2021
STochastic Optical Reconstruction Microscopy (STORM) reveals the nanoscale organization of pathological aggregates in human brain.Neuropathology and applied neurobiology, , Volume: 47, Issue:1, 2021
RT-QUiC in multiple system atrophy: the biomarker of the future? and other updates on recent autonomic research.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 31, Issue:1, 2021
Different patterns of hippocampal subfield pathology in Lewy body disease and Alzheimer's disease.Neuropathology and applied neurobiology, , Volume: 47, Issue:5, 2021
Establishment of Method for the Determination of Aggregated α-Synuclein in DLB Patient Using RT-QuIC Assay.Protein and peptide letters, , Volume: 28, Issue:1, 2021
Neuropathology and molecular diagnosis of Synucleinopathies.Molecular neurodegeneration, , 12-18, Volume: 16, Issue:1, 2021
Seeding Propensity and Characteristics of Pathogenic αSyn Assemblies in Formalin-Fixed Human Tissue from the Enteric Nervous System, Olfactory Bulb, and Brainstem in Cases Staged for Parkinson's Disease.Cells, , 01-12, Volume: 10, Issue:1, 2021
Tyrosine 136 phosphorylation of α-synuclein aggregates in the Lewy body dementia brain: involvement of serine 129 phosphorylation by casein kinase 2.Acta neuropathologica communications, , 11-12, Volume: 9, Issue:1, 2021
Neuropathological evidence of body-first vs. brain-first Lewy body disease.Neurobiology of disease, , Volume: 161, 2021
Association between CSF alpha-synuclein seeding activity and genetic status in Parkinson's disease and dementia with Lewy bodies.Acta neuropathologica communications, , 10-30, Volume: 9, Issue:1, 2021
Lewy pathology of the submandibular gland in Lewy body disease: A report of autopsy cases.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 41, Issue:6, 2021
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Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer's Disease.Medicina (Kaunas, Lithuania), , Sep-10, Volume: 57, Issue:9, 2021
Microglia is associated with p-Tau aggregates in the olfactory bulb of patients with neurodegenerative diseases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 42, Issue:4, 2021
Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo.Nature communications, , 09-10, Volume: 12, Issue:1, 2021
Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model.Molecular neurodegeneration, , 09-09, Volume: 16, Issue:1, 2021
Lewy Body Pathology: From Amyloidosis to Vesicle Trafficking.Protein and peptide letters, , Volume: 28, Issue:11, 2021
Neuropathology of Lewy body disease: Clinicopathological crosstalk between typical and atypical cases.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 40, Issue:1, 2020
Small vessel disease pathological changes in neurodegenerative and vascular dementias concomitant with autonomic dysfunction.Brain pathology (Zurich, Switzerland), , Volume: 30, Issue:1, 2020
Impaired metabolic brain networks associated with neurotransmission systems in the α-synuclein spectrum.Parkinsonism & related disorders, , Volume: 81, 2020
CD8 T cell nigral infiltration precedes synucleinopathy in early stages of Parkinson's disease.Brain : a journal of neurology, , 12-01, Volume: 143, Issue:12, 2020
Comparison of 123I-MIBG scintigraphy and phosphorylated α-synuclein skin deposits in synucleinopathies.Parkinsonism & related disorders, , Volume: 81, 2020
Orthostatic hypotension as a core symptom in a Japanese family harboring SNCA duplication.Parkinsonism & related disorders, , Volume: 81, 2020
Neuronal activity modulates alpha-synuclein aggregation and spreading in organotypic brain slice cultures and in vivo.Acta neuropathologica, , Volume: 140, Issue:6, 2020
Differential diagnostic value of total alpha-synuclein assay in the cerebrospinal fluid between Alzheimer's disease and dementia with Lewy bodies from the prodromal stage.Alzheimer's research & therapy, , 09-29, Volume: 12, Issue:1, 2020
How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structNeurobiology of disease, , Volume: 146, 2020
Blinded RT-QuIC Analysis of α-Synuclein Biomarker in Skin Tissue From Parkinson's Disease Patients.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:12, 2020
Associations of sleep characteristics with alpha-synuclein in cerebrospinal fluid in older adults.Annals of clinical and translational neurology, , Volume: 7, Issue:10, 2020
The Nosology of Lewy Body Disorders From Analytic-Epidemiologic and Statistical Vantage Points.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:12, 2020
Hippocampal subfield pathologic burden in Lewy body diseases vs. Alzheimer's disease.Neuropathology and applied neurobiology, , Volume: 46, Issue:7, 2020
Novel antibodies detect additional α-synuclein pathology in synucleinopathies: potential development for immunotherapy.Alzheimer's research & therapy, , 11-30, Volume: 12, Issue:1, 2020
A novel SNCA E83Q mutation in a case of dementia with Lewy bodies and atypical frontotemporal lobar degeneration.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 40, Issue:6, 2020
Discoidin Domain Receptor 1 is a therapeutic target for neurodegenerative diseases.Human molecular genetics, , 10-10, Volume: 29, Issue:17, 2020
Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor.International journal of molecular sciences, , Jul-22, Volume: 21, Issue:15, 2020
Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models.Journal of neuroinflammation, , Jul-17, Volume: 17, Issue:1, 2020
Subtypes of dementia with Lewy bodies are associated with α-synuclein and tau distribution.Neurology, , 07-14, Volume: 95, Issue:2, 2020
Alpha-Synuclein Oligomers and Neurofilament Light Chain in Spinal Fluid Differentiate Multiple System Atrophy from Lewy Body Synucleinopathies.Annals of neurology, , Volume: 88, Issue:3, 2020
TDP-1/TDP-43 potentiates human α-Synuclein (HASN) neurodegeneration in Caenorhabditis elegans.Biochimica et biophysica acta. Molecular basis of disease, , 10-01, Volume: 1866, Issue:10, 2020
Infections or Sepsis Preceding Clinically Diagnosed α-Synucleinopathies: A Case-Control Study.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:9, 2020
Anti-aggregation Effects of Phenolic Compounds on α-synuclein.Molecules (Basel, Switzerland), , May-24, Volume: 25, Issue:10, 2020
Detection and Assessment of α-Synuclein Oligomers in the Urine of Parkinson's Disease Patients.Journal of Parkinson's disease, , Volume: 10, Issue:3, 2020
Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity.Scientific reports, , 05-18, Volume: 10, Issue:1, 2020
The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson's disease, multiple system atrophy and dementia with Lewy bodies.Acta neuropathologica, , Volume: 139, Issue:6, 2020
Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies.Acta neuropathologica, , Volume: 140, Issue:1, 2020
Investigating the presence of doubly phosphorylated α-synuclein at tyrosine 125 and serine 129 in idiopathic Lewy body diseases.Brain pathology (Zurich, Switzerland), , Volume: 30, Issue:4, 2020
Analysis of Protein Conformational Strains-A Key for New Diagnostic Methods of Human Diseases.International journal of molecular sciences, , Apr-17, Volume: 21, Issue:8, 2020
Systematic review of gene expression studies in people with Lewy body dementia.Acta neuropsychiatrica, , Volume: 32, Issue:6, 2020
Autonomic dysfunction is associated with neuropsychological impairment in Lewy body disease.Journal of neurology, , Volume: 267, Issue:7, 2020
The Leukotriene Receptor Antagonist Montelukast Reduces Alpha-Synuclein Load and Restores Memory in an Animal Model of Dementia with Lewy Bodies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 17, Issue:3, 2020
RT-QuIC-based detection of alpha-synuclein seeding activity in brains of dementia with Lewy Body patients and of a transgenic mouse model of synucleinopathy.Prion, , Volume: 14, Issue:1, 2020
[α-Synuclein as Diagnostic Biomarker].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:2, 2020
[REM Sleep Behavior Disorder and α-synucleinopathy].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:2, 2020
APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid.Science translational medicine, , 02-05, Volume: 12, Issue:529, 2020
Fabry Disease With Concomitant Lewy Body Disease.Journal of neuropathology and experimental neurology, , 04-01, Volume: 79, Issue:4, 2020
The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure.Proceedings of the National Academy of Sciences of the United States of America, , 02-18, Volume: 117, Issue:7, 2020
Fine-Mapping of SNCA in Rapid Eye Movement Sleep Behavior Disorder and Overt Synucleinopathies.Annals of neurology, , Volume: 87, Issue:4, 2020
Aβ Puts the Alpha in Synuclein.Neuron, , 01-22, Volume: 105, Issue:2, 2020
NK cells clear α-synuclein and the depletion of NK cells exacerbates synuclein pathology in a mouse model of α-synucleinopathy.Proceedings of the National Academy of Sciences of the United States of America, , 01-21, Volume: 117, Issue:3, 2020
Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult.Neuron, , 03-04, Volume: 105, Issue:5, 2020
Systematic review of genetic association studies in people with Lewy body dementia.International journal of geriatric psychiatry, , Volume: 35, Issue:5, 2020
Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease.Neurobiology of disease, , Volume: 136, 2020
Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology.Neuron, , 01-22, Volume: 105, Issue:2, 2020
α-Synuclein real-time quaking-induced conversion in the submandibular glands of Parkinson's disease patients.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:2, 2020
Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia.Brain : a journal of neurology, , 01-01, Volume: 143, Issue:1, 2020
Pathologically Decreased CSF Levels of Synaptic Marker NPTX2 in DLB Are Correlated with Levels of Alpha-Synuclein and VGF.Cells, , 12-29, Volume: 10, Issue:1, 2020
The value of cerebrospinal fluid α-synuclein and the tau/α-synuclein ratio for diagnosis of neurodegenerative disorders with Lewy pathology.European journal of neurology, , Volume: 27, Issue:1, 2020
[A case of severe obstructive sleep apnea mimicking REM sleep behavior disorder].Rinsho shinkeigaku = Clinical neurology, , Apr-25, Volume: 59, Issue:4, 2019
Unified Staging System for Lewy Body Disorders: Clinicopathologic Correlations and Comparison to Braak Staging.Journal of neuropathology and experimental neurology, , 10-01, Volume: 78, Issue:10, 2019
Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression.Acta neuropathologica communications, , 09-02, Volume: 7, Issue:1, 2019
Seeding of protein aggregation causes cognitive impairment in rat model of cortical synucleinopathy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:11, 2019
Intriguing Mixed Pathologic Features in a Case of Dementia With Lewy Bodies.The Journal of the American Osteopathic Association, , Sep-01, Volume: 119, Issue:9, 2019
Erythrocytes as Biomarkers for Dementia: Analysis of Protein Content and Alpha-Synuclein.Journal of Alzheimer's disease : JAD, , 08-12, Volume: 71, Issue:2, 2019
Alzheimer's disease and other neurodegenerative dementias in comorbidity: A clinical and neuropathological overview.Clinical biochemistry, , Volume: 73, 2019
Ultrasensitive Detection of Aggregated α-Synuclein in Glial Cells, Human Cerebrospinal Fluid, and Brain Tissue Using the RT-QuIC Assay: New High-Throughput Neuroimmune Biomarker Assay for Parkinsonian Disorders.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 14, Issue:3, 2019
Expression of α-synuclein is regulated in a neuronal cell type-dependent manner.Anatomical science international, , Volume: 94, Issue:1, 2019
Differential diagnosis between Alzheimer's disease and other dementias: Role of cerebrospinal fluid biomarkers.Clinical biochemistry, , Volume: 72, 2019
Phosphorylated NUB1 distinguishes α-synuclein in Lewy bodies from that in glial cytoplasmic inclusions in multiple system atrophy.Brain pathology (Zurich, Switzerland), , Volume: 29, Issue:6, 2019
Differential insular cortex subregional vulnerability to α-synuclein pathology in Parkinson's disease and dementia with Lewy bodies.Neuropathology and applied neurobiology, , Volume: 45, Issue:3, 2019
Path mediation analysis reveals GBA impacts Lewy body disease status by increasing α-synuclein levels.Neurobiology of disease, , Volume: 121, 2019
TIGAR inclusion pathology is specific for Lewy body diseases.Brain research, , 03-01, Volume: 1706, 2019
Increased Serum Levels of α-Synuclein in Patients With Major Depressive Disorder.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, , Volume: 27, Issue:3, 2019
Alpha-synuclein structure and Parkinson's disease - lessons and emerging principles.Molecular neurodegeneration, , 07-22, Volume: 14, Issue:1, 2019
Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders.Scientific reports, , 07-29, Volume: 9, Issue:1, 2019
Ammon's Horn 2 (CA2) of the Hippocampus: A Long-Known Region with a New Potential Role in Neurodegeneration.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, , Volume: 25, Issue:2, 2019
Precision Medicine in Rapid Eye Movement Sleep Behavior Disorder.Sleep medicine clinics, , Volume: 14, Issue:3, 2019
Measurement of CSF α-synuclein improves early differential diagnosis of mild cognitive impairment due to Alzheimer's disease.Journal of neurochemistry, , Volume: 150, Issue:2, 2019
Effects of single and combined immunotherapy approach targeting amyloid β protein and α-synuclein in a dementia with Lewy bodies-like model.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 15, Issue:9, 2019
Heterogeneity in α-synuclein subtypes and their expression in cortical brain tissue lysates from Lewy body diseases and Alzheimer's disease.Neuropathology and applied neurobiology, , Volume: 45, Issue:6, 2019
Parafoveal thinning of inner retina is associated with visual dysfunction in Lewy body diseases.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:9, 2019
Coexisting Lewy body disease and clinical parkinsonism in frontotemporal lobar degeneration.Neurology, , 05-21, Volume: 92, Issue:21, 2019
GBA1-associated parkinsonism: new insights and therapeutic opportunities.Current opinion in neurology, , Volume: 32, Issue:4, 2019
Dementia with lewy bodies: GBA1 mutations are associated with cerebrospinal fluid alpha-synuclein profile.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:7, 2019
Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes.Nature neuroscience, , Volume: 22, Issue:7, 2019
Degeneration of dopaminergic circuitry influences depressive symptoms in Lewy body disorders.Brain pathology (Zurich, Switzerland), , Volume: 29, Issue:4, 2019
Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration.Brain pathology (Zurich, Switzerland), , Volume: 29, Issue:1, 2019
[Prion-like Propagation of Pathological α-Synuclein in Vivo].Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, , Volume: 139, Issue:7, 2019
Dementia with Lewy bodies - from scientific knowledge to clinical insights.Nature reviews. Neurology, , Volume: 15, Issue:2, 2019
Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders.Annals of neurology, , Volume: 85, Issue:2, 2019
Polysomnographic data in Dementia with Lewy Bodies: correlation with clinical symptoms and comparison with other α-synucleinopathies.Sleep medicine, , Volume: 55, 2019
[Real-time Quaking-induced Conversion Analysis of Prion-like Seeding Activity of Pathological α-Synuclein].Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, , Volume: 139, Issue:7, 2019
Neuropathological and genetic characteristics of a post-mortem series of cases with dementia with Lewy bodies clinically suspected of Creutzfeldt-Jakob's disease.Parkinsonism & related disorders, , Volume: 63, 2019
Abundance of Synaptic Vesicle-Related Proteins in Alpha-Synuclein-Containing Protein Inclusions Suggests a Targeted Formation Mechanism.Neurotoxicity research, , Volume: 35, Issue:4, 2019
The heart of PD: Lewy body diseases as neurocardiologic disorders.Brain research, , 01-01, Volume: 1702, 2019
α-Synuclein and astrocytes: tracing the pathways from homeostasis to neurodegeneration in Lewy body disease.Acta neuropathologica, , Volume: 138, Issue:1, 2019
Associations Between APOE Variants, Tau and α-Synuclein.Advances in experimental medicine and biology, , Volume: 1184, 2019
Extreme sleep pattern in Lewy body dementia: a hypothalamic matter?BMJ case reports, , Mar-09, Volume: 12, Issue:3, 2019
The center of olfactory bulb-seeded α-synucleinopathy is the limbic system and the ensuing pathology is higher in male than in female mice.Brain pathology (Zurich, Switzerland), , Volume: 29, Issue:6, 2019
Late-Life Depression and Lewy Body Disease.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, , Volume: 27, Issue:3, 2019
Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid - method comparison and round robin study.Journal of neurochemistry, , Volume: 149, Issue:1, 2019
Clinical and neuropathological differences between Parkinson's disease, Parkinson's disease dementia and dementia with Lewy bodies - current issues and future directions.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Classification of GBA Variants and Their Effects in Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:10, 2019
Behavioral symptomatology and psychopharmacology of Lewy body dementia.Handbook of clinical neurology, , Volume: 165, 2019
Investigating the Association Between Verbal Forgetting and Pathological Markers of Alzheimer's and Lewy Body Diseases.Journal of Alzheimer's disease : JAD, , Volume: 70, Issue:3, 2019
α-Synuclein oligomers mediate the aberrant form of spike-induced calcium release from IPScientific reports, , 11-04, Volume: 9, Issue:1, 2019
Stabilization of α-synuclein oligomers using formaldehyde.PloS one, , Volume: 14, Issue:10, 2019
Lower nucleus accumbens α-synuclein load and D3 receptor levels in Parkinson's disease with impulsive compulsive behaviours.Brain : a journal of neurology, , 11-01, Volume: 142, Issue:11, 2019
[Differential diagnosis of RBD symptomatology (idiopathic RBD or RBD mimics)].Rinsho shinkeigaku = Clinical neurology, , Apr-25, Volume: 59, Issue:4, 2019
α-Synuclein RT-QuIC assay in cerebrospinal fluid of patients with dementia with Lewy bodies.Annals of clinical and translational neurology, , Volume: 6, Issue:10, 2019
Simultaneous quantification of tau and α-synuclein in cerebrospinal fluid by high-resolution mass spectrometry for differentiation of Lewy Body Dementia from Alzheimer's Disease and controls.The Analyst, , Oct-22, Volume: 144, Issue:21, 2019
VGF Peptides in Cerebrospinal Fluid of Patients with Dementia with Lewy Bodies.International journal of molecular sciences, , Sep-20, Volume: 20, Issue:19, 2019
Ceftriaxone Treatment for Neuronal Deficits: A Histological and MEMRI Study in a Rat Model of Dementia with Lewy Bodies.Behavioural neurology, , Volume: 2018, 2018
Predicting alpha-synuclein pathology by REM sleep behavior disorder diagnosis.Parkinsonism & related disorders, , Volume: 55, 2018
Diagnostic value of cerebrospinal fluid alpha-synuclein in dementia with Lewy body.Geriatrie et psychologie neuropsychiatrie du vieillissement, , Sep-01, Volume: 16, Issue:3, 2018
Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson's disease and DLB.Proceedings of the National Academy of Sciences of the United States of America, , 12-18, Volume: 115, Issue:51, 2018
α-Synuclein aggregates in labial salivary glands of idiopathic rapid eye movement sleep behavior disorder.Sleep, , 08-01, Volume: 41, Issue:8, 2018
Skin α-synuclein deposits differ in clinical variants of synucleinopathy: an in vivo study.Scientific reports, , 09-24, Volume: 8, Issue:1, 2018
Relationships between lewy and tau pathologies in 375 consecutive non-Alzheimer's olfactory bulbs.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:2, 2018
Associations between ZnT3, tau pathology, agitation, and delusions in dementia.International journal of geriatric psychiatry, , Volume: 33, Issue:8, 2018
A refined concept: α-synuclein dysregulation disease.Neurochemistry international, , Volume: 119, 2018
Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated.Brain : a journal of neurology, , 07-01, Volume: 141, Issue:7, 2018
Lewy Body Dementia.Clinics in geriatric medicine, , Volume: 34, Issue:4, 2018
Acid ceramidase inhibition ameliorates α-synuclein accumulation upon loss of GBA1 function.Human molecular genetics, , 06-01, Volume: 27, Issue:11, 2018
Rapid eye movement sleep behavior disorder and the link to alpha-synucleinopathies.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, , Volume: 129, Issue:8, 2018
A novel link between trafficking and Lewy body disorders.The Lancet. Neurology, , Volume: 17, Issue:7, 2018
Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC.Acta neuropathologica communications, , 02-09, Volume: 6, Issue:1, 2018
INDEL Length and Haplotypes in the β-Synuclein Gene: A Key to Differentiate Dementia with Lewy Bodies?Journal of Alzheimer's disease : JAD, , Volume: 65, Issue:1, 2018
Effects of Novel Calpain Inhibitors in Transgenic Animal Model of Parkinson's disease/dementia with Lewy bodies.Scientific reports, , 12-27, Volume: 8, Issue:1, 2018
Accumulation of beta-synuclein in cortical neurons is associated with autophagy attenuation in the brains of dementia with Lewy body patients.Brain research, , 02-15, Volume: 1681, 2018
Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods.Acta neuropathologica communications, , 04-18, Volume: 6, Issue:1, 2018
Improving the identification of dementia with Lewy bodies in the context of an Alzheimer's-type dementia.Alzheimer's research & therapy, , 03-01, Volume: 10, Issue:1, 2018
Methylation changes and aberrant expression of FGFR3 in Lewy body disease neurons.Brain research, , 10-15, Volume: 1697, 2018
Alzheimer disease biomarkers and synucleinopathy.Neurology, , 03-20, Volume: 90, Issue:12, 2018
Genetics of Synucleinopathies.Cold Spring Harbor perspectives in medicine, , 06-01, Volume: 8, Issue:6, 2018
Reader response: A new potential biomarker for dementia with Lewy bodies: Skin nerve α-synuclein deposits.Neurology, , 03-13, Volume: 90, Issue:11, 2018
α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton.Neuron, , 01-03, Volume: 97, Issue:1, 2018
FKBP12-immunopositive inclusions in patients with α-synucleinopathies.Brain research, , 02-01, Volume: 1680, 2018
14-3-3 protein sigma isoform co-localizes with phosphorylated α-synuclein in Lewy bodies and Lewy neurites in patients with Lewy body disease.Neuroscience letters, , 05-01, Volume: 674, 2018
Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports.Journal of neuropathology and experimental neurology, , 09-01, Volume: 77, Issue:9, 2018
Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype.Autophagy, , Volume: 14, Issue:1, 2018
Propagation of alpha-synuclein pathology from the olfactory bulb: possible role in the pathogenesis of dementia with Lewy bodies.Cell and tissue research, , Volume: 373, Issue:1, 2018
The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson's disease.Scientific reports, , 11-01, Volume: 8, Issue:1, 2018
Regional levels of physiological α-synuclein are directly associated with Lewy body pathology.Acta neuropathologica, , Volume: 135, Issue:1, 2018
Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies.Nature, , Volume: 557, Issue:7706, 2018
[Autonomic Dysfunction and Skin Biopsy in Dementia with Lewy Bodies].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 70, Issue:8, 2018
The limbic and neocortical contribution of α-synuclein, tau, and amyloid β to disease duration in dementia with Lewy bodies.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 14, Issue:3, 2018
Neuropsychiatric symptoms and α-Synuclein profile of patients with Parkinson's disease dementia, dementia with Lewy bodies and Alzheimer's disease.Journal of neurology, , Volume: 265, Issue:10, 2018
Dexamethasone Inhibits Copper-Induced Alpha-Synuclein Aggregation by a Metallothionein-Dependent Mechanism.Neurotoxicity research, , Volume: 33, Issue:2, 2018
Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease.Autophagy, , Volume: 14, Issue:8, 2018
α-Synuclein species as potential cerebrospinal fluid biomarkers for dementia with lewy bodies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:11, 2018
Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation.Molecular neurodegeneration, , 08-09, Volume: 13, Issue:1, 2018
14-3-3 Proteins Reduce Cell-to-Cell Transfer and Propagation of Pathogenic α-Synuclein.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 09-19, Volume: 38, Issue:38, 2018
Author response: A new potential biomarker for dementia with Lewy bodies: Skin nerve α-synuclein deposits.Neurology, , 03-13, Volume: 90, Issue:11, 2018
Phosphorylated α-synuclein in the retina is a biomarker of Parkinson's disease pathology severity.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:8, 2018
Spectrum of abnormalities of sympathetic tyrosine hydroxylase and alpha-synuclein in chronic autonomic failure.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 28, Issue:2, 2018
Molecular changes in the absence of severe pathology in the pulvinar in dementia with Lewy bodies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:6, 2018
Implications of Metal Binding and Asparagine Deamidation for Amyloid Formation.International journal of molecular sciences, , Aug-19, Volume: 19, Issue:8, 2018
[Multi-Organ Distribution of Alpha-Synuclein Pathology in Dementia with Lewy Bodies].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 70, Issue:5, 2018
Interaction of amyloidogenic proteins in pancreatic β cells from subjects with synucleinopathies.Acta neuropathologica, , Volume: 135, Issue:6, 2018
Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 14, Issue:8, 2018
ɑ-Synuclein strains and seeding in Parkinson's disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences.Cell and tissue research, , Volume: 373, Issue:1, 2018
Survival and Causes of Death Among People With Clinically Diagnosed Synucleinopathies With Parkinsonism: A Population-Based Study.JAMA neurology, , 07-01, Volume: 74, Issue:7, 2017
Amygdala α-Synuclein Pathology in the Population-Based Vantaa 85+ Study.Journal of Alzheimer's disease : JAD, , Volume: 58, Issue:3, 2017
Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid.JAMA neurology, , Feb-01, Volume: 74, Issue:2, 2017
Parkinson disease: Antibodies reveal age of Lewy pathology in PD.Nature reviews. Neurology, , Volume: 13, Issue:6, 2017
Fluorescence and autoradiographic evaluation of tau PET ligand PBB3 to α-synuclein pathology.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:6, 2017
Involvement of the cerebellum in Parkinson disease and dementia with Lewy bodies.Annals of neurology, , Volume: 81, Issue:6, 2017
Genetic analysis of α-synuclein 3' untranslated region and its corresponding microRNAs in relation to Parkinson's disease compared to dementia with Lewy bodies.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 13, Issue:11, 2017
Lewy Body Disorders.Neurologic clinics, , Volume: 35, Issue:2, 2017
DNA methylation changes at SNCA intron 1 in patients with dementia with Lewy bodies.Psychiatry and clinical neurosciences, , Volume: 71, Issue:1, 2017
Regional Overlap of Pathologies in Lewy Body Disorders.Journal of neuropathology and experimental neurology, , 03-01, Volume: 76, Issue:3, 2017
Changes in CD200 and intercellular adhesion molecule-1 (ICAM-1) levels in brains of Lewy body disorder cases are associated with amounts of Alzheimer's pathology not α-synuclein pathology.Neurobiology of aging, , Volume: 54, 2017
Lewy Bodies and the Mechanisms of Neuronal Cell Death in Parkinson's Disease and Dementia with Lewy Bodies.Brain pathology (Zurich, Switzerland), , Volume: 27, Issue:1, 2017
Effects of α-synuclein on axonal transport.Neurobiology of disease, , Volume: 105, 2017
Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis.The Lancet. Neurology, , Volume: 16, Issue:1, 2017
Hippocampal α-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and Is Consistent with Spread of Pathology.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 02-15, Volume: 37, Issue:7, 2017
Neuronal Loss and Α-Synuclein Pathology in the Superior Colliculus and Its Relationship to Visual Hallucinations in Dementia with Lewy Bodies.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, , Volume: 25, Issue:6, 2017
Human Neural Progenitor Transplantation Rescues Behavior and Reduces α-Synuclein in a Transgenic Model of Dementia with Lewy Bodies.Stem cells translational medicine, , Volume: 6, Issue:6, 2017
Metabolic connectomics targeting brain pathology in dementia with Lewy bodies.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 37, Issue:4, 2017
Neuropathology of PARK14 is identical to idiopathic Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:5, 2017
Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.Disease models & mechanisms, , 05-01, Volume: 10, Issue:5, 2017
Histones facilitate α-synuclein aggregation during neuronal apoptosis.Acta neuropathologica, , Volume: 133, Issue:4, 2017
A preclinical screen to evaluate pharmacotherapies for the treatment of agitation in dementia.Behavioural pharmacology, , Volume: 28, Issue:2 and 3-Sp, 2017
Synaptic phosphorylated α-synuclein in dementia with Lewy bodies.Brain : a journal of neurology, , Dec-01, Volume: 140, Issue:12, 2017
Potential Modes of Intercellular α-Synuclein Transmission.International journal of molecular sciences, , Feb-22, Volume: 18, Issue:2, 2017
α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies.Nature medicine, , Feb-07, Volume: 23, Issue:2, 2017
Synucleinopathies: common features and hippocampal manifestations.Cellular and molecular life sciences : CMLS, , Volume: 74, Issue:8, 2017
Quantitative neuropathology: an update on automated methodologies and implications for large scale cohorts.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 124, Issue:6, 2017
Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells.Human molecular genetics, , 09-15, Volume: 26, Issue:18, 2017
A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies.PloS one, , Volume: 12, Issue:9, 2017
Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity.Acta neuropathologica communications, , 01-10, Volume: 5, Issue:1, 2017
The Synucleinopathies: Twenty Years On.Journal of Parkinson's disease, , Volume: 7, Issue:s1, 2017
Integrated analysis of genetic, behavioral, and biochemical data implicates neural stem cell-induced changes in immunity, neurotransmission and mitochondrial function in Dementia with Lewy Body mice.Acta neuropathologica communications, , 03-10, Volume: 5, Issue:1, 2017
Increased Transforming Growth Factor β2 in the Neocortex of Alzheimer's Disease and Dementia with Lewy Bodies is Correlated with Disease Severity and Soluble Aβ42 Load.Journal of Alzheimer's disease : JAD, , Volume: 56, Issue:1, 2017
Differential role of CSF fatty acid binding protein 3, α-synuclein, and Alzheimer's disease core biomarkers in Lewy body disorders and Alzheimer's dementia.Alzheimer's research & therapy, , Jul-28, Volume: 9, Issue:1, 2017
New Therapeutic Strategies for Lewy Body Dementias.Current neurology and neuroscience reports, , Volume: 17, Issue:9, 2017
Dementia: Skin α-synuclein deposits - a new biomarker for DLB?Nature reviews. Neurology, , Volume: 13, Issue:9, 2017
An order in Lewy body disorders: Retrograde degeneration in hyperbranching axons as a fundamental structural template accounting for focal/multifocal Lewy body disease.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 37, Issue:2, 2017
A new potential biomarker for dementia with Lewy bodies: Skin nerve α-synuclein deposits.Neurology, , Jul-25, Volume: 89, Issue:4, 2017
Dementia with Lewy bodies: Diagnosis is only skin deep?Neurology, , 07-25, Volume: 89, Issue:4, 2017
Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology.Acta neuropathologica communications, , 06-09, Volume: 5, Issue:1, 2017
Endothelin-converting enzymes degrade α-synuclein and are reduced in dementia with Lewy bodies.Journal of neurochemistry, , Volume: 141, Issue:2, 2017
Lewy- and Alzheimer-type pathologies in midbrain and cerebellum across the Lewy body disorders spectrum.Neuropathology and applied neurobiology, , Volume: 42, Issue:5, 2016
Longitudinal live imaging of retinal α-synuclein::GFP deposits in a transgenic mouse model of Parkinson's Disease/Dementia with Lewy Bodies.Scientific reports, , 07-08, Volume: 6, 2016
The role of NUB1 in α-synuclein degradation in Lewy body disease model mice.Biochemical and biophysical research communications, , Feb-12, Volume: 470, Issue:3, 2016
Synaptic failure and α-synuclein.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Prevalence of Submandibular Gland Synucleinopathy in Parkinson's Disease, Dementia with Lewy Bodies and other Lewy Body Disorders.Journal of Parkinson's disease, , Volume: 6, Issue:1, 2016
Review: The spectrum of clinical features seen with alpha synuclein pathology.Neuropathology and applied neurobiology, , Volume: 42, Issue:1, 2016
Therapeutic approaches in Parkinson's disease and related disorders.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Lewy body pathology involves the olfactory cells in Parkinson's disease and related disorders.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:1, 2016
α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.Human molecular genetics, , Mar-15, Volume: 25, Issue:6, 2016
Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology.Acta neuropathologica, , Volume: 131, Issue:3, 2016
Development of Passive Immunotherapies for Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Review: Spreading the word: precise animal models and validated methods are vital when evaluating prion-like behaviour of alpha-synuclein.Neuropathology and applied neurobiology, , Volume: 42, Issue:1, 2016
Analysis of primary visual cortex in dementia with Lewy bodies indicates GABAergic involvement associated with recurrent complex visual hallucinations.Acta neuropathologica communications, , 06-30, Volume: 4, Issue:1, 2016
LRRK2 variation and dementia with Lewy bodies.Parkinsonism & related disorders, , Volume: 31, 2016
Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies.Brain : a journal of neurology, , Volume: 139, Issue:Pt 2, 2016
Neurodegeneration in tauopathies and synucleinopathies.Revue neurologique, , Volume: 172, Issue:11, 2016
α-Synuclein pathology in the cranial and spinal nerves in Lewy body disease.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 36, Issue:3, 2016
Microglia in dementia with Lewy bodies.Brain, behavior, and immunity, , Volume: 55, 2016
Amyloid-β suppresses AMP-activated protein kinase (AMPK) signaling and contributes to α-synuclein-induced cytotoxicity.Experimental neurology, , Volume: 275 Pt 1, 2016
Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease.Proceedings of the National Academy of Sciences of the United States of America, , 08-09, Volume: 113, Issue:32, 2016
Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.Acta neuropathologica, , Volume: 131, Issue:1, 2016
Combination therapies: The next logical Step for the treatment of synucleinopathies?Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Pure Autonomic Failure.Current neurology and neuroscience reports, , Volume: 16, Issue:8, 2016
Alpha-synuclein aggregates are excluded from calbindin-D28k-positive neurons in dementia with Lewy bodies and a unilateral rotenone mouse model.Molecular and cellular neurosciences, , Volume: 77, 2016
Accumulation of phosphorylated α-synuclein in subpial and periventricular astrocytes in multiple system atrophy of long duration.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 36, Issue:2, 2016
New insights into cellular α-synuclein homeostasis in health and disease.Current opinion in neurobiology, , Volume: 36, 2016
Unfolded protein response is activated in Lewy body dementias.Neuropathology and applied neurobiology, , Volume: 42, Issue:4, 2016
'Under pressure': is there a link between orthostatic hypotension and cognitive impairment in α-synucleinopathies?Journal of neurology, neurosurgery, and psychiatry, , Volume: 87, Issue:12, 2016
α-Synuclein: Experimental Pathology.Cold Spring Harbor perspectives in medicine, , Sep-01, Volume: 6, Issue:9, 2016
Subcortical matter in the α-synucleinopathies spectrum: an MRI pilot study.Journal of neurology, , Volume: 263, Issue:8, 2016
A novel therapeutic approach for synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:12, 2016
shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity.PLoS genetics, , Volume: 12, Issue:4, 2016
α-synuclein genetic variability: A biomarker for dementia in Parkinson disease.Annals of neurology, , Volume: 79, Issue:6, 2016
Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?Journal of Parkinson's disease, , Volume: 6, Issue:1, 2016
Up-regulation of SNCA gene expression: implications to synucleinopathies.Neurogenetics, , Volume: 17, Issue:3, 2016
ɑ-Synuclein strains and the variable pathologies of synucleinopathies.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Imaging synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:6, 2016
Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril.Scientific reports, , 08-04, Volume: 6, 2016
Parkinson's disease and prion disease: Straining the comparison.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:13, 2015
Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein.Acta neuropathologica communications, , Nov-26, Volume: 3, 2015
Transmission of Soluble and Insoluble α-Synuclein to Mice.Journal of neuropathology and experimental neurology, , Volume: 74, Issue:12, 2015
Aneuploidy in Lewy body diseases.Neurobiology of aging, , Volume: 36, Issue:3, 2015
Untangling a role for tau in synucleinopathies.Biological psychiatry, , Nov-15, Volume: 78, Issue:10, 2015
Neuroinflammation in Lewy body dementia.Parkinsonism & related disorders, , Volume: 21, Issue:12, 2015
Neural Stem Cells Rescue Cognitive and Motor Dysfunction in a Transgenic Model of Dementia with Lewy Bodies through a BDNF-Dependent Mechanism.Stem cell reports, , Nov-10, Volume: 5, Issue:5, 2015
Behavioural deficits in transgenic mice expressing human truncated (1-120 amino acid) alpha-synuclein.Experimental neurology, , Volume: 264, 2015
p62 Deficiency Enhances α-Synuclein Pathology in Mice.Brain pathology (Zurich, Switzerland), , Volume: 25, Issue:5, 2015
Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson's Disease-like Dementia.Cell, , Oct-08, Volume: 163, Issue:2, 2015
Cerebrospinal fluid levels of IL-6 are decreased and correlate with cognitive status in DLB patients.Alzheimer's research & therapy, , Oct-05, Volume: 7, Issue:1, 2015
Function of α-synuclein and PINK1 in Lewy body dementia (Review).International journal of molecular medicine, , Volume: 35, Issue:1, 2015
Distribution of α-synuclein in the spinal cord and dorsal root ganglia in an autopsy cohort of elderly persons.Acta neuropathologica communications, , Sep-15, Volume: 3, 2015
Role for the microtubule-associated protein tau variant p.A152T in risk of α-synucleinopathies.Neurology, , Nov-10, Volume: 85, Issue:19, 2015
Trehalose intake induces chaperone molecules along with autophagy in a mouse model of Lewy body disease.Biochemical and biophysical research communications, , Oct-02, Volume: 465, Issue:4, 2015
Cerebrospinal fluid α-synuclein and Lewy body-like symptoms in normal controls, mild cognitive impairment, and Alzheimer's disease.Journal of Alzheimer's disease : JAD, , Volume: 43, Issue:3, 2015
Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias.Brain pathology (Zurich, Switzerland), , Volume: 25, Issue:4, 2015
The brainstem pathologies of Parkinson's disease and dementia with Lewy bodies.Brain pathology (Zurich, Switzerland), , Volume: 25, Issue:2, 2015
Parkinson disease: Disease-linked morphometric variants of α-synuclein.Nature reviews. Neurology, , Volume: 11, Issue:8, 2015
A cytosine-thymine (CT)-rich haplotype in intron 4 of SNCA confers risk for Lewy body pathology in Alzheimer's disease and affects SNCA expression.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 11, Issue:10, 2015
α-Synuclein strains cause distinct synucleinopathies after local and systemic administration.Nature, , Jun-18, Volume: 522, Issue:7556, 2015
Neurodegeneration: Aggregates feel the strain.Nature, , Jun-18, Volume: 522, Issue:7556, 2015
Expanding the spectrum of neuronal pathology in multiple system atrophy.Brain : a journal of neurology, , Volume: 138, Issue:Pt 8, 2015
Pathological interface between oligomeric alpha-synuclein and tau in synucleinopathies.Biological psychiatry, , Nov-15, Volume: 78, Issue:10, 2015
Multiple system atrophy: the application of genetics in understanding etiology.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 25, Issue:1, 2015
Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders.Science signaling, , May-12, Volume: 8, Issue:376, 2015
Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology.Neurobiology of disease, , Volume: 79, 2015
Parkinson's disease and alpha-synucleinopathies: from arising pathways to therapeutic challenge.Central nervous system agents in medicinal chemistry, , Volume: 15, Issue:2, 2015
α-Synuclein pathology accumulates in sacral spinal visceral sensory pathways.Annals of neurology, , Volume: 78, Issue:1, 2015
Use of CSF α-synuclein in the differential diagnosis between Alzheimer's disease and other neurodegenerative disorders.International psychogeriatrics, , Volume: 27, Issue:9, 2015
Targeting α-synuclein oligomers by protein-fragment complementation for drug discovery in synucleinopathies.Expert opinion on therapeutic targets, , Volume: 19, Issue:5, 2015
Neuropathologically mixed Alzheimer's and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes.Acta neuropathologica, , Volume: 129, Issue:5, 2015
α-Synucleinopathy phenotypes.Parkinsonism & related disorders, , Volume: 20 Suppl 1, 2014
Accumulation of α-synuclein in dementia with Lewy bodies is associated with decline in the α-synuclein-degrading enzymes kallikrein-6 and calpain-1.Acta neuropathologica communications, , Dec-05, Volume: 2, 2014
Neurogranin binds α-synuclein in the human superior temporal cortex and interaction is decreased in Parkinson's disease.Brain research, , Dec-03, Volume: 1591, 2014
In vivo markers of Parkinson's disease and dementia with Lewy bodies: current value of the 5G4 α-synuclein antibody.Acta neuropathologica, , Volume: 128, Issue:6, 2014
Modeling Lewy pathology propagation in Parkinson's disease.Parkinsonism & related disorders, , Volume: 20 Suppl 1, 2014
Calcineurin determines toxic versus beneficial responses to α-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , Aug-26, Volume: 111, Issue:34, 2014
Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson's disease patients.Acta neuropathologica communications, , Aug-07, Volume: 2, 2014
Flow cytometry analysis of synaptosomes from post-mortem human brain reveals changes specific to Lewy body and Alzheimer's disease.Laboratory investigation; a journal of technical methods and pathology, , Volume: 94, Issue:10, 2014
Parkinson disease: A monoclonal antibody targeting misfolded α-synuclein has therapeutic potential in Parkinson disease.Nature reviews. Neurology, , Volume: 10, Issue:8, 2014
Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneurons.PloS one, , Volume: 9, Issue:7, 2014
Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:10, 2014
Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies.Human molecular genetics, , Dec-01, Volume: 23, Issue:23, 2014
Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration.Cell reports, , Jun-26, Volume: 7, Issue:6, 2014
Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodies.Molecular neurodegeneration, , May-19, Volume: 9, 2014
Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread.Neurobiology of disease, , Volume: 69, 2014
Convergence of pathology in dementia with Lewy bodies and Alzheimer's disease: a role for the novel interaction of alpha-synuclein and presenilin 1 in disease.Brain : a journal of neurology, , Volume: 137, Issue:Pt 7, 2014
Alpha-synuclein immunohistochemistry of gastrointestinal and biliary surgical specimens for diagnosis of Lewy body disease.International journal of clinical and experimental pathology, , Volume: 7, Issue:4, 2014
[Alpha-Synuclein in blood and cerebrospinal fluid of patients with alpha-synucleinopathy].Rinsho byori. The Japanese journal of clinical pathology, , Volume: 62, Issue:3, 2014
Analysis of Parkinson's disease brain-derived DNA for alpha-synuclein coding somatic mutations.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:8, 2014
Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson's disease.Neurobiology of aging, , Volume: 35, Issue:10, 2014
Neuropathological investigation of hypocretin expression in brains of dementia with Lewy bodies.Neuroscience letters, , May-21, Volume: 569, 2014
Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo.Brain : a journal of neurology, , Volume: 137, Issue:Pt 5, 2014
Phospholipase D1 regulates autophagic flux and clearance of α-synuclein aggregates.Cell death and differentiation, , Volume: 21, Issue:7, 2014
Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA.Acta neuropathologica communications, , Mar-13, Volume: 2, 2014
Next-generation active immunization approach for synucleinopathies: implications for Parkinson's disease clinical trials.Acta neuropathologica, , Volume: 127, Issue:6, 2014
Reduced vascular endothelial growth factor and capillary density in the occipital cortex in dementia with Lewy bodies.Brain pathology (Zurich, Switzerland), , Volume: 24, Issue:4, 2014
Degeneration of brainstem respiratory neurons in dementia with Lewy bodies.Sleep, , Feb-01, Volume: 37, Issue:2, 2014
Comment: Braak staging in clinical practice?Neurology, , Mar-11, Volume: 82, Issue:10, 2014
Immunotherapy targeting α-synuclein, with relevance for future treatment of Parkinson's disease and other Lewy body disorders.Immunotherapy, , Volume: 6, Issue:2, 2014
Immunogenicity of epitope vaccines targeting different B cell antigenic determinants of human α-synuclein: feasibility study.Neuroscience letters, , Feb-07, Volume: 560, 2014
Extracellular α--synuclein-a novel and crucial factor in Lewy body diseases.Nature reviews. Neurology, , Volume: 10, Issue:2, 2014
Increased CSF α-synuclein levels in Alzheimer's disease: correlation with tau levels.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 10, Issue:5 Suppl, 2014
Immunohistochemical localization of spatacsin in α-synucleinopathies.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 34, Issue:2, 2014
Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:8, 2014
Glucocerebrosidase, a new player changing the old rules in Lewy body diseases.Biological chemistry, , Volume: 394, Issue:7, 2013
Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia.Nature communications, , Volume: 4, 2013
Prion-like spreading of pathological α-synuclein in brain.Brain : a journal of neurology, , Volume: 136, Issue:Pt 4, 2013
Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study.The Lancet. Neurology, , Volume: 12, Issue:5, 2013
Confluence of α-synuclein, tau, and β-amyloid pathologies in dementia with Lewy bodies.Journal of neuropathology and experimental neurology, , Volume: 72, Issue:12, 2013
Parkinsonism, dementia and glucocerebrosidase mutations.Journal of neurology, , Volume: 260, Issue:5, 2013
Altered serum IgG levels to α-synuclein in dementia with Lewy bodies and Alzheimer's disease.PloS one, , Volume: 8, Issue:5, 2013
Limelight on alpha-synuclein: pathological and mechanistic implications in neurodegeneration.Journal of Parkinson's disease, , Volume: 3, Issue:4, 2013
CSF levels of the neuronal injury biomarker visinin-like protein-1 in Alzheimer's disease and dementia with Lewy bodies.Journal of neurochemistry, , Volume: 127, Issue:5, 2013
The impact of pathogenic mitochondrial DNA mutations on substantia nigra neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jun-26, Volume: 33, Issue:26, 2013
[Α-synuclein as a biomarker for early diagnosis of Parkinsonism].Rinsho shinkeigaku = Clinical neurology, , Volume: 53, Issue:11, 2013
SMG1 identified as a regulator of Parkinson's disease-associated alpha-synuclein through siRNA screening.PloS one, , Volume: 8, Issue:10, 2013
The diagnostic utility of cerebrospinal fluid alpha-synuclein analysis in dementia with Lewy bodies - a systematic review and meta-analysis.Parkinsonism & related disorders, , Volume: 19, Issue:10, 2013
Pantothenate kinase-associated neurodegeneration is not a synucleinopathy.Neuropathology and applied neurobiology, , Volume: 39, Issue:2, 2013
Lentivirus mediated delivery of neurosin promotes clearance of wild-type α-synuclein and reduces the pathology in an α-synuclein model of LBD.Molecular therapy : the journal of the American Society of Gene Therapy, , Volume: 21, Issue:1, 2013
[Hyperbranching axons template α-synuclein deposits and non-localizing clinical manifestations of Parkinson disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 65, Issue:12, 2013
The Lewy body in Parkinson's disease and related neurodegenerative disorders.Molecular neurobiology, , Volume: 47, Issue:2, 2013
Neuropathologic analysis of Lewy-related α-synucleinopathy in olfactory mucosa.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 33, Issue:1, 2013
MAPT H1 haplotype is associated with enhanced α-synuclein deposition in dementia with Lewy bodies.Neurobiology of aging, , Volume: 34, Issue:3, 2013
The potential prognostic role of cardiovascular autonomic failure in α-synucleinopathies.European journal of neurology, , Volume: 20, Issue:2, 2013
Alpha-synuclein aggregates in epicardial fat tissue in living subjects without parkinsonism.Parkinsonism & related disorders, , Volume: 19, Issue:1, 2013
α-Synuclein posttranslational modification and alternative splicing as a trigger for neurodegeneration.Molecular neurobiology, , Volume: 47, Issue:2, 2013
Personalized medicine strategies for managing patients with parkinsonism and cognitive deficits.Metabolism: clinical and experimental, , Volume: 62 Suppl 1, 2013
Dysfunction of the locus coeruleus-norepinephrine system and related circuitry in Parkinson's disease-related dementia.Journal of neurology, neurosurgery, and psychiatry, , Volume: 84, Issue:7, 2013
100 years of Lewy pathology.Nature reviews. Neurology, , Volume: 9, Issue:1, 2013
Changes in properties of serine 129 phosphorylated α-synuclein with progression of Lewy-type histopathology in human brains.Experimental neurology, , Volume: 240, 2013
Low CSF levels of both α-synuclein and the α-synuclein cleaving enzyme neurosin in patients with synucleinopathy.PloS one, , Volume: 8, Issue:1, 2013
Axonopathy in an α-synuclein transgenic model of Lewy body disease is associated with extensive accumulation of C-terminal-truncated α-synuclein.The American journal of pathology, , Volume: 182, Issue:3, 2013
Submandibular gland biopsy for the diagnosis of Parkinson disease.Journal of neuropathology and experimental neurology, , Volume: 72, Issue:2, 2013
Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α-synuclein transgenic mice with the disease-causing A30P mutation.Journal of neurochemistry, , Volume: 126, Issue:1, 2013
MRI and pathology of REM sleep behavior disorder in dementia with Lewy bodies.Neurology, , Nov-05, Volume: 81, Issue:19, 2013
Lewy body pathology in a patient with a homozygous parkin deletion.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:3, 2013
ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies.Acta neuropathologica communications, , May-09, Volume: 1, 2013
The diagnostic value of CSF α-synuclein in the differential diagnosis of dementia with Lewy bodies vs. normal subjects and patients with Alzheimer's disease.PloS one, , Volume: 8, Issue:11, 2013
Neuropathological analysis of brainstem cholinergic and catecholaminergic nuclei in relation to rapid eye movement (REM) sleep behaviour disorder.Neuropathology and applied neurobiology, , Volume: 38, Issue:2, 2012
Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 22, Issue:1, 2012
Post mortem cerebrospinal fluid α-synuclein levels are raised in multiple system atrophy and distinguish this from the other α-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies.Neurobiology of disease, , Volume: 45, Issue:1, 2012
α-synuclein phosphorylation and truncation are normal events in the adult human brain.Neuroscience, , Jan-03, Volume: 200, 2012
Neuropathology of sporadic Parkinson's disease: evaluation and changes of concepts.Movement disorders : official journal of the Movement Disorder Society, , Volume: 27, Issue:1, 2012
Phosphorylated α-synuclein immunoreactivity in the posterior pituitary lobe.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 32, Issue:4, 2012
Synucleinopathies from bench to bedside.Parkinsonism & related disorders, , Volume: 18 Suppl 1, 2012
Altered CSF orexin and α-synuclein levels in dementia patients.Journal of Alzheimer's disease : JAD, , Volume: 29, Issue:1, 2012
Lewy body-related α-synucleinopathy in the spinal cord of cases with incidental Lewy body disease.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 32, Issue:1, 2012
Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation.The FEBS journal, , Volume: 279, Issue:6, 2012
An evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology.Journal of neurology, neurosurgery, and psychiatry, , Volume: 83, Issue:4, 2012
Lewy-like aggregation of α-synuclein reduces protein phosphatase 2A activity in vitro and in vivo.Neuroscience, , Apr-05, Volume: 207, 2012
Pathologic evaluation of the supraoptic and paraventricular nuclei in dementia.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, , Volume: 39, Issue:2, 2012
Biochemical increase in phosphorylated alpha-synuclein precedes histopathology of Lewy-type synucleinopathies.Brain pathology (Zurich, Switzerland), , Volume: 22, Issue:6, 2012
Relationship between mitochondria and α-synuclein: a study of single substantia nigra neurons.Archives of neurology, , Volume: 69, Issue:3, 2012
Critical role of truncated α-synuclein and aggregates in Parkinson's disease and incidental Lewy body disease.Brain pathology (Zurich, Switzerland), , Volume: 22, Issue:6, 2012
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice.The Journal of experimental medicine, , May-07, Volume: 209, Issue:5, 2012
α-Synuclein mRNA and soluble α-synuclein protein levels in post-mortem brain from patients with Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease.Brain research, , Jun-12, Volume: 1459, 2012
[Cerebrospinal fluid and plasma biomarkers for dementia with lewy bodies].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 64, Issue:5, 2012
[An 87-year-old women with the clinical diagnosis of dementia with Lewy bodies without α-synuclein deposition].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 64, Issue:5, 2012
Proteasome inhibition leads to early loss of synaptic proteins in neuronal culture.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 119, Issue:12, 2012
The genetics of dementia with Lewy bodies: what are we missing?Archives of neurology, , Volume: 69, Issue:9, 2012
Methamphetamine binds to α-synuclein and causes a conformational change which can be detected by nanopore analysis.FEBS letters, , Sep-21, Volume: 586, Issue:19, 2012
Neuropathological investigation of the hypometabolic regions on positron emission tomography with [18F] fluorodeoxyglucose in patients with dementia with Lewy bodies.Journal of the neurological sciences, , Mar-15, Volume: 314, Issue:1-2, 2012
Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research.PloS one, , Volume: 7, Issue:7, 2012
Spinal cord lesions in sporadic Parkinson's disease.Acta neuropathologica, , Volume: 124, Issue:5, 2012
Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H β-synuclein.Molecular brain, , Sep-26, Volume: 5, 2012
Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Sep-26, Volume: 32, Issue:39, 2012
GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology.Neurology, , Nov-06, Volume: 79, Issue:19, 2012
Possible alterations in β-Synuclein, the non-amyloidogenic homologue of α-Synuclein, during progression of sporadic α-synucleinopathies.International journal of molecular sciences, , Volume: 13, Issue:9, 2012
Role of α-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrus.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-21, Volume: 32, Issue:47, 2012
Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?Brain : a journal of neurology, , Volume: 134, Issue:Pt 5, 2011
Proteasome inhibition induces α-synuclein SUMOylation and aggregate formation.Journal of the neurological sciences, , Aug-15, Volume: 307, Issue:1-2, 2011
Identification of novel α-synuclein isoforms in human brain tissue by using an online nanoLC-ESI-FTICR-MS method.Neurochemical research, , Volume: 36, Issue:11, 2011
Familial Parkinson disease mutations influence α-synuclein assembly.Neurobiology of disease, , Volume: 43, Issue:3, 2011
Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases.The Journal of biological chemistry, , Mar-18, Volume: 286, Issue:11, 2011
CSF amyloid-β peptides in neuropathologically diagnosed dementia with Lewy bodies and Alzheimer's disease.Journal of Alzheimer's disease : JAD, , Volume: 24, Issue:2, 2011
Neuropathology underlying clinical variability in patients with synucleinopathies.Acta neuropathologica, , Volume: 122, Issue:2, 2011
α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jul-06, Volume: 31, Issue:27, 2011
CD3 in Lewy pathology: does the abnormal recall of neurodevelopmental processes underlie Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 118, Issue:1, 2011
Decreased α-synuclein serum levels in patients with Lewy body dementia compared to Alzheimer's disease patients and control subjects.Dementia and geriatric cognitive disorders, , Volume: 31, Issue:6, 2011
α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study.The Lancet. Neurology, , Volume: 10, Issue:3, 2011
Neurogenic marker abnormalities in the hippocampus in dementia with Lewy bodies.Hippocampus, , Volume: 21, Issue:10, 2011
Incidental Lewy body disease: do some cases represent a preclinical stage of dementia with Lewy bodies?Neurobiology of aging, , Volume: 32, Issue:5, 2011
Synphilin-1-binding protein NUB1 is colocalized with nonfibrillar, proteinase K-resistant α-synuclein in presynapses in Lewy body disease.Journal of neuropathology and experimental neurology, , Volume: 70, Issue:10, 2011
Pathological roles of α-synuclein in neurological disorders.The Lancet. Neurology, , Volume: 10, Issue:11, 2011
Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing.Annals of neurology, , Volume: 69, Issue:6, 2011
[Pathologic substrate of synucleinopathies. Introduction].Revista espanola de geriatria y gerontologia, , Volume: 46 Suppl 1, 2011
[Role of genetics in the etiology of synucleinopathies].Revista espanola de geriatria y gerontologia, , Volume: 46 Suppl 1, 2011
Striatal β-amyloid in dementia with Lewy bodies but not Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 118, Issue:5, 2011
Alpha-synuclein is a cellular ferrireductase.PloS one, , Jan-10, Volume: 6, Issue:1, 2011
[Lewy bodies and Lewy neurites].Nihon rinsho. Japanese journal of clinical medicine, , Volume: 69 Suppl 8, 2011
Next-generation sequencing reveals regional differences of the α-synuclein methylation state independent of Lewy body disease.Neuromolecular medicine, , Volume: 13, Issue:4, 2011
Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease.PloS one, , Apr-29, Volume: 6, Issue:4, 2011
Parkinson's disease with dementia, lewy-body disorders and alpha-synuclein: recent advances and a case report.Acta neurologica Taiwanica, , Volume: 20, Issue:1, 2011
Prevalence and pathology of dementia with Lewy bodies in the oldest old: a comparison with other dementing disorders.Dementia and geriatric cognitive disorders, , Volume: 31, Issue:4, 2011
Partial loss of parvalbumin-containing hippocampal interneurons in dementia with Lewy bodies.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 31, Issue:1, 2011
New insights into atypical parkinsonism.Current opinion in neurology, , Volume: 24, Issue:4, 2011
Autoantibodies against amyloid and glial-derived antigens are increased in serum and cerebrospinal fluid of Lewy body-associated dementias.Journal of Alzheimer's disease : JAD, , Volume: 26, Issue:1, 2011
α-Synuclein fate is determined by USP9X-regulated monoubiquitination.Proceedings of the National Academy of Sciences of the United States of America, , Nov-15, Volume: 108, Issue:46, 2011
Association of alpha-, beta-, and gamma-Synuclein with diffuse lewy body disease.Archives of neurology, , Volume: 67, Issue:8, 2010
Distinct region-specific alpha-synuclein oligomers in A53T transgenic mice: implications for neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-03, Volume: 30, Issue:9, 2010
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-03, Volume: 30, Issue:9, 2010
Abnormal neurites containing C-terminally truncated alpha-synuclein are present in Alzheimer's disease without conventional Lewy body pathology.The American journal of pathology, , Volume: 177, Issue:6, 2010
Evidence in favor of Braak staging of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 25 Suppl 1, 2010
Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy.PloS one, , Feb-19, Volume: 5, Issue:2, 2010
Pure autonomic failure: a restricted Lewy body synucleinopathy or early Parkinson disease?Neurology, , Feb-16, Volume: 74, Issue:7, 2010
Neuroimaging for Lewy body disease: is the in vivo molecular imaging of α-synuclein neuropathology required and feasible?Brain research reviews, , Oct-05, Volume: 65, Issue:1, 2010
Amyloid imaging of Lewy body-associated disorders.Movement disorders : official journal of the Movement Disorder Society, , Nov-15, Volume: 25, Issue:15, 2010
Effect of topographical distribution of α-synuclein pathology on TDP-43 accumulation in Lewy body disease.Acta neuropathologica, , Volume: 120, Issue:6, 2010
REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century.Neurology, , Aug-10, Volume: 75, Issue:6, 2010
TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in the brain of Parkinson's disease and dementia with Lewy bodies.Neurobiology of disease, , Volume: 38, Issue:2, 2010
Brain stem pathology in Parkinson's disease: an evaluation of the Braak staging model.Movement disorders : official journal of the Movement Disorder Society, , Nov-15, Volume: 25, Issue:15, 2010
Neuroscience and heart-brain medicine: the year in review.Cleveland Clinic journal of medicine, , Volume: 77 Suppl 3, 2010
Lovastatin ameliorates alpha-synuclein accumulation and oxidation in transgenic mouse models of alpha-synucleinopathies.Experimental neurology, , Volume: 221, Issue:2, 2010
The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia.Acta neuropathologica, , Volume: 120, Issue:2, 2010
Caspase-cleaved transactivation response DNA-binding protein 43 in Parkinson's disease and dementia with Lewy bodies.Neuro-degenerative diseases, , Volume: 7, Issue:4, 2010
Differential levels of alpha-synuclein, beta-amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer's disease.Journal of neurology, neurosurgery, and psychiatry, , Volume: 81, Issue:6, 2010
A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death.Neurobiology of aging, , Volume: 31, Issue:1, 2010
CSF synuclein: adding to the biomarker footprint of dementia with Lewy bodies.Journal of neurology, neurosurgery, and psychiatry, , Volume: 81, Issue:6, 2010
Distribution of cerebral amyloid deposition and its relevance to clinical phenotype in Lewy body dementia.Neuroscience letters, , Dec-03, Volume: 486, Issue:1, 2010
Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity.PloS one, , Nov-16, Volume: 5, Issue:11, 2010
Neuropathology of dementia with Lewy bodies in advanced age: a comparison with Alzheimer disease.Neuroscience letters, , Nov-26, Volume: 485, Issue:3, 2010
Glucocerebrosidase is present in α-synuclein inclusions in Lewy body disorders.Acta neuropathologica, , Volume: 120, Issue:5, 2010
Proteinase K-resistant alpha-synuclein is deposited in presynapses in human Lewy body disease and A53T alpha-synuclein transgenic mice.Acta neuropathologica, , Volume: 120, Issue:2, 2010
Biomarkers: Parkinson disease with dementia and dementia with Lewy bodies.Parkinsonism & related disorders, , Volume: 16, Issue:5, 2010
alpha-Synuclein antibodies recognize a protein present at lower levels in the CSF of patients with dementia with Lewy bodies.International psychogeriatrics, , Volume: 22, Issue:2, 2010
Dementia with Lewy bodies associated with ataxia, myoclonus, and cortical blindness.Movement disorders : official journal of the Movement Disorder Society, , Jul-15, Volume: 25, Issue:9, 2010
Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders.Acta neuropathologica, , Volume: 119, Issue:6, 2010
Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease.Acta neuropathologica, , Volume: 119, Issue:6, 2010
Are synucleinopathies prion-like disorders?The Lancet. Neurology, , Volume: 9, Issue:11, 2010
CSF α-synuclein does not discriminate dementia with Lewy bodies from Alzheimer's disease.Journal of Alzheimer's disease : JAD, , Volume: 22, Issue:1, 2010
Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies.Brain : a journal of neurology, , Volume: 132, Issue:Pt 4, 2009
Early-onset familial lewy body dementia with extensive tauopathy: a clinical, genetic, and neuropathological study.Journal of neuropathology and experimental neurology, , Volume: 68, Issue:1, 2009
CSF alpha-synuclein levels in dementia with Lewy bodies and Alzheimer's disease.Brain research, , Jan-28, Volume: 1251, 2009
Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss?Neuroscience letters, , Feb-06, Volume: 450, Issue:3, 2009
Dopamine cell loss in the periaqueductal gray in multiple system atrophy and Lewy body dementia.Neurology, , Jul-14, Volume: 73, Issue:2, 2009
Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders.Acta neuropathologica, , Volume: 117, Issue:2, 2009
Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders.Acta neuropathologica, , Volume: 117, Issue:2, 2009
Intralaminar nuclei of the thalamus in Lewy body diseases.Brain research bulletin, , Feb-16, Volume: 78, Issue:2-3, 2009
Lewy body variant of Alzheimer's disease: selective neocortical loss of t-SNARE proteins and loss of MAP2 and alpha-synuclein in medial temporal lobe.TheScientificWorldJournal, , Dec-16, Volume: 9, 2009
Creutzfeldt-jakob, Parkinson, lewy body dementia and Alzheimer diseases: from diagnosis to therapy.Central nervous system agents in medicinal chemistry, , Volume: 9, Issue:1, 2009
In vitro characterisation of BF227 binding to alpha-synuclein/Lewy bodies.European journal of pharmacology, , Sep-01, Volume: 617, Issue:1-3, 2009
Lrrk2 interaction with alpha-synuclein in diffuse Lewy body disease.Biochemical and biophysical research communications, , Dec-25, Volume: 390, Issue:4, 2009
Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Oct-28, Volume: 29, Issue:43, 2009
A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders.Biochimica et biophysica acta, , Volume: 1792, Issue:7, 2009
Clinical correlates of pathology in the claustrum in Parkinson's disease and dementia with Lewy bodies.Neuroscience letters, , Sep-11, Volume: 461, Issue:1, 2009
Dorsal motor nucleus of vagus protein aggregates in Lewy body disease with autonomic dysfunction.Brain research, , Aug-25, Volume: 1286, 2009
Intrinsic disorder in proteins associated with neurodegenerative diseases.Frontiers in bioscience (Landmark edition), , 06-01, Volume: 14, Issue:14, 2009
Incidental Lewy body disease restricted to the heart and stellate ganglia.Movement disorders : official journal of the Movement Disorder Society, , Nov-15, Volume: 24, Issue:15, 2009
The association between mutations in the lysosomal protein glucocerebrosidase and parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Aug-15, Volume: 24, Issue:11, 2009
The genetics of Parkinson's syndromes: a critical review.Current opinion in genetics & development, , Volume: 19, Issue:3, 2009
Formation and development of Lewy pathology: a critical update.Journal of neurology, , Volume: 256 Suppl 3, 2009
Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction.Acta neuropathologica, , Volume: 117, Issue:6, 2009
Molecular pathology of Lewy body diseases.International journal of molecular sciences, , Volume: 10, Issue:3, 2009
Leucine-rich repeat kinase 2 expression leads to aggresome formation that is not associated with alpha-synuclein inclusions.Journal of neuropathology and experimental neurology, , Volume: 68, Issue:7, 2009
Biochemical and pathological correlates of cognitive and behavioural change in DLB/PDD.Journal of neurology, , Volume: 256 Suppl 3, 2009
Heavy alcohol consumption and neuropathological lesions: a post-mortem human study.Journal of neuroscience research, , Volume: 87, Issue:12, 2009
Regional differences in the severity of Lewy body pathology across the olfactory cortex.Neuroscience letters, , Apr-03, Volume: 453, Issue:2, 2009
Staging/typing of Lewy body related alpha-synuclein pathology: a study of the BrainNet Europe Consortium.Acta neuropathologica, , Volume: 117, Issue:6, 2009
Anti-aggregation and fibril-destabilizing effects of sex hormones on alpha-synuclein fibrils in vitro.Experimental neurology, , Volume: 217, Issue:2, 2009
Nuclear and neuritic distribution of serine-129 phosphorylated alpha-synuclein in transgenic mice.Neuroscience, , Jun-02, Volume: 160, Issue:4, 2009
Neuropathologic findings of dementia with lewy bodies (DLB) in a population-based Vantaa 85+ study.Journal of Alzheimer's disease : JAD, , Volume: 18, Issue:3, 2009
Neurotoxic conversion of beta-synuclein: a novel approach to generate a transgenic mouse model of synucleinopathies?Journal of neurology, , Volume: 256 Suppl 3, 2009
Parkinson's disease dementia and dementia with Lewy bodies: different aspects of one entity.International psychogeriatrics, , Volume: 21, Issue:2, 2009
Recent advances in the genetics of dementia with lewy bodies.Current neurology and neuroscience reports, , Volume: 8, Issue:3, 2008
Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease.The FEBS journal, , Volume: 275, Issue:23, 2008
The therapeutical potential of alpha-synuclein antiaggregatory agents for dementia with Lewy bodies.Current medicinal chemistry, , Volume: 15, Issue:26, 2008
Alpha- and gamma-synuclein proteins are present in cerebrospinal fluid and are increased in aged subjects with neurodegenerative and vascular changes.Dementia and geriatric cognitive disorders, , Volume: 26, Issue:1, 2008
Validation of the neuropathologic criteria of the third consortium for dementia with Lewy bodies for prospectively diagnosed cases.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:7, 2008
Evaluation of alpha-synuclein immunohistochemical methods used by invited experts.Acta neuropathologica, , Volume: 116, Issue:3, 2008
Early alpha-synuclein lipoxidation in neocortex in Lewy body diseases.Neurobiology of aging, , Volume: 29, Issue:3, 2008
Identification and characterization of a new alpha-synuclein isoform and its role in Lewy body diseases.Neurogenetics, , Volume: 9, Issue:1, 2008
Commentary to "Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease".Neurochemical research, , Volume: 33, Issue:6, 2008
Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease.Brain : a journal of neurology, , Volume: 131, Issue:Pt 3, 2008
Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies.Experimental neurology, , Volume: 210, Issue:2, 2008
Early discriminatory diagnosis of dementia with Lewy bodies. The emerging role of CSF and imaging biomarkers.Dementia and geriatric cognitive disorders, , Volume: 25, Issue:3, 2008
Transgenic mice overexpressing tyrosine-to-cysteine mutant human alpha-synuclein: a progressive neurodegenerative model of diffuse Lewy body disease.The Journal of biological chemistry, , Apr-11, Volume: 283, Issue:15, 2008
A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides.Nature neuroscience, , Volume: 11, Issue:3, 2008
Differential expression of alpha-synuclein, parkin, and synphilin-1 isoforms in Lewy body disease.Neurogenetics, , Volume: 9, Issue:3, 2008
Selective detection, quantification, and subcellular location of alpha-synuclein aggregates with a protein aggregate filtration assay.BioTechniques, , Volume: 44, Issue:3, 2008
Patterns and stages of alpha-synucleinopathy: Relevance in a population-based cohort.Neurology, , Mar-25, Volume: 70, Issue:13, 2008
[Clinical and pathological study on early diagnosis of Parkinson's disease and dementia with Lewy bodies].Rinsho shinkeigaku = Clinical neurology, , Volume: 48, Issue:1, 2008
Proteasomal abnormalities in cortical Lewy body disease and the impact of proteasomal inhibition within cortical and cholinergic systems.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 115, Issue:6, 2008
An atypical autopsy case of Lewy body disease with clinically diagnosed major depression: a clinical, radiological and pathological study.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 28, Issue:6, 2008
Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementia.Archives of neurology, , Volume: 65, Issue:4, 2008
Striatal beta-amyloid deposition in Parkinson disease with dementia.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:5, 2008
Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:10, 2008
Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases.PloS one, , Sep-04, Volume: 3, Issue:9, 2008
[Clinical and pathological study on early diagnosis of Parkinson's disease and dementia with Lewy bodies].Rinsho shinkeigaku = Clinical neurology, , Volume: 48, Issue:11, 2008
[Molecular neuropathology of Non-Alzheimer dementia].Der Pathologe, , Volume: 29, Issue:6, 2008
Cerebrospinal fluid of Alzheimer's disease and dementia with Lewy bodies patients enhances alpha-synuclein fibril formation in vitro.Experimental neurology, , Volume: 203, Issue:2, 2007
Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease.Sleep medicine, , Volume: 8, Issue:1, 2007
Vitamin A potently destabilizes preformed alpha-synuclein fibrils in vitro: implications for Lewy body diseases.Neurobiology of disease, , Volume: 25, Issue:2, 2007
Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated alpha-synuclein.Journal of neuroinflammation, , Jan-04, Volume: 4, 2007
PINK1, a gene product of PARK6, accumulates in alpha-synucleinopathy brains.Journal of neurology, neurosurgery, and psychiatry, , Volume: 78, Issue:6, 2007
Synucleinopathy with features of both multiple system atrophy and dementia with Lewy bodies.Neuropathology and applied neurobiology, , Volume: 33, Issue:1, 2007
Correlation in Lewy pathology between the claustrum and visual areas in brains of dementia with Lewy bodies.Neuroscience letters, , Mar-30, Volume: 415, Issue:3, 2007
Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-07, Volume: 27, Issue:6, 2007
[Animal models of neurodegenerative diseases].Medecine sciences : M/S, , Volume: 23, Issue:2, 2007
Lewy body variant of Alzheimer's disease or cerebral type lewy body disease? Two autopsy cases of presenile onset with minimal involvement of the brainstem.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 27, Issue:1, 2007
Anti-fibrillogenic and fibril-destabilizing activity of nicotine in vitro: implications for the prevention and therapeutics of Lewy body diseases.Experimental neurology, , Volume: 205, Issue:2, 2007
Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation.The American journal of pathology, , Volume: 170, Issue:5, 2007
Analysis of the adrenal gland is useful for evaluating pathology of the peripheral autonomic nervous system in lewy body disease.Journal of neuropathology and experimental neurology, , Volume: 66, Issue:5, 2007
Do alpha-synuclein aggregates in autonomic plexuses predate Lewy body disorders?: a cohort study.Neurology, , Jun-05, Volume: 68, Issue:23, 2007
Alpha-synuclein pathology in the olfactory pathways of dementia patients.Journal of anatomy, , Volume: 211, Issue:1, 2007
Classical Parkinson disease versus Parkinson complex--reflections against staging and in favour of heterogeneity.European journal of neurology, , Volume: 14, Issue:7, 2007
Rostral raphe involvement in Lewy body dementia and multiple system atrophy.Acta neuropathologica, , Volume: 114, Issue:3, 2007
In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution.Neurology, , Jul-24, Volume: 69, Issue:4, 2007
Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases.Acta neuropathologica, , Volume: 114, Issue:3, 2007
An investigation into the lipid-binding properties of alpha-, beta- and gamma-synucleins in human brain and cerebrospinal fluid.Brain research, , Sep-19, Volume: 1170, 2007
A 75-year-old man with cognitive impairment and gait changes.Neurology, , Sep-11, Volume: 69, Issue:11, 2007
Transgenic animal models of neurodegenerative diseases and their application to treatment development.Advanced drug delivery reviews, , Sep-30, Volume: 59, Issue:11, 2007
In vitro characterization of Pittsburgh compound-B binding to Lewy bodies.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Sep-26, Volume: 27, Issue:39, 2007
Concurrence of TDP-43, tau and alpha-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies.Brain research, , Dec-12, Volume: 1184, 2007
Phosphorylated Smad 2/3 colocalizes with phospho-tau inclusions in Pick disease, progressive supranuclear palsy, and corticobasal degeneration but not with alpha-synuclein inclusions in multiple system atrophy or dementia with Lewy bodies.Journal of neuropathology and experimental neurology, , Volume: 66, Issue:11, 2007
Pathological biochemistry of alpha-synucleinopathy.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 27, Issue:5, 2007
Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-28, Volume: 27, Issue:48, 2007
Neuropathology of Parkinson's disease dementia and dementia with Lewy bodies with reference to striatal pathology.Parkinsonism & related disorders, , Volume: 13 Suppl 3, 2007
Positron emission tomography changes in PARK1 mutation.Movement disorders : official journal of the Movement Disorder Society, , Volume: 21, Issue:1, 2006
Pathophysiology of synuclein aggregation in Lewy body disease.Mechanisms of ageing and development, , Volume: 127, Issue:2, 2006
Positive immunoreactivity for vesicular monoamine transporter 2 in Lewy bodies and Lewy neurites in substantia nigra.Neuroscience letters, , Apr-03, Volume: 396, Issue:3, 2006
Clinical and biochemical correlates of insoluble alpha-synuclein in dementia with Lewy bodies.Acta neuropathologica, , Volume: 111, Issue:2, 2006
Antioxidant compounds have potent anti-fibrillogenic and fibril-destabilizing effects for alpha-synuclein fibrils in vitro.Journal of neurochemistry, , Volume: 97, Issue:1, 2006
Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization.Nature chemical biology, , Volume: 2, Issue:5, 2006
REM sleep behavior disorder: a possible early marker for synucleinopathies.Neurology, , Mar-28, Volume: 66, Issue:6, 2006
Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients.Proceedings of the National Academy of Sciences of the United States of America, , Apr-11, Volume: 103, Issue:15, 2006
Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Apr-12, Volume: 26, Issue:15, 2006
Anticipation of onset age in familial Parkinson's disease without SCA gene mutations.Parkinsonism & related disorders, , Volume: 12, Issue:5, 2006
Investigation of Lewy pathology in the visual pathway of brains of dementia with Lewy bodies.Journal of the neurological sciences, , Jul-15, Volume: 246, Issue:1-2, 2006
Biochemical staging of synucleinopathy and amyloid deposition in dementia with Lewy bodies.Journal of neuropathology and experimental neurology, , Volume: 65, Issue:3, 2006
Alzheimer disease with amygdala Lewy bodies: a distinct form of alpha-synucleinopathy.Journal of neuropathology and experimental neurology, , Volume: 65, Issue:7, 2006
Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease.The Journal of biological chemistry, , Oct-06, Volume: 281, Issue:40, 2006
Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease.Neurochemical research, , Volume: 31, Issue:9, 2006
Low alpha-synuclein 126 mRNA levels in dementia with Lewy bodies and Alzheimer disease.Neuroreport, , Aug-21, Volume: 17, Issue:12, 2006
Dementia with Lewy bodies in an elderly Greek male due to alpha-synuclein gene mutation.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, , Volume: 13, Issue:9, 2006
Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation.Biochemical and biophysical research communications, , Dec-22, Volume: 351, Issue:3, 2006
Cortical Lewy body disease and Parkinson's disease dementia.Current opinion in neurology, , Volume: 19, Issue:6, 2006
Identification of G-protein coupled receptor kinase 2 in paired helical filaments and neurofibrillary tangles.Journal of neuropathology and experimental neurology, , Volume: 65, Issue:12, 2006
Differences in neuropathologic characteristics across the Lewy body dementia spectrum.Neurology, , Dec-12, Volume: 67, Issue:11, 2006
The role of alpha-synuclein gene multiplications in early-onset Parkinson's disease and dementia with Lewy bodies.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 112, Issue:9, 2005
Tuft-shaped astrocytes in Lewy body disease.Acta neuropathologica, , Volume: 109, Issue:4, 2005
Genetic association between the APOE*4 allele and Lewy bodies in Alzheimer disease.Neurology, , Feb-08, Volume: 64, Issue:3, 2005
A mutant PSEN1 causes dementia with Lewy bodies and variant Alzheimer's disease.Annals of neurology, , Volume: 57, Issue:3, 2005
Idiopathic REM sleep behavior disorder: toward a better nosologic definition.Neurology, , Mar-08, Volume: 64, Issue:5, 2005
Abundant neuritic inclusions and microvacuolar changes in a case of diffuse Lewy body disease with the A53T mutation in the alpha-synuclein gene.Acta neuropathologica, , Volume: 110, Issue:3, 2005
Cognitive differences in dementia patients with autopsy-verified AD, Lewy body pathology, or both.Neurology, , Jun-28, Volume: 64, Issue:12, 2005
Abnormal sleep architecture is an early feature in the E46K familial synucleinopathy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20, Issue:10, 2005
Genetics of Parkinson's disease.Annals of medicine, , Volume: 37, Issue:2, 2005
How to diagnose dementia with Lewy bodies: state of the art.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
Alpha-synuclein dysfunction in Lewy body diseases.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
Evidence of oxidative stress in the neocortex in incidental Lewy body disease.Journal of neuropathology and experimental neurology, , Volume: 64, Issue:9, 2005
Non-uniformity in the regional pattern of Lewy pathology in brains of dementia with Lewy bodies.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 25, Issue:3, 2005
Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium.Neurology, , Dec-27, Volume: 65, Issue:12, 2005
Alpha-synuclein and chaperones in dementia with Lewy bodies.Journal of neuropathology and experimental neurology, , Volume: 64, Issue:12, 2005
Novel presenilin 1 mutation (S170F) causing Alzheimer disease with Lewy bodies in the third decade of life.Archives of neurology, , Volume: 62, Issue:12, 2005
Widespread and abundant alpha-synuclein pathology in a neurologically unimpaired subject.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 25, Issue:4, 2005
Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective.The Journal of biological chemistry, , Feb-06, Volume: 279, Issue:6, 2004
Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy.Acta neuropathologica, , Volume: 107, Issue:4, 2004
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia.Annals of neurology, , Volume: 55, Issue:2, 2004
Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity.The Journal of biological chemistry, , Jun-11, Volume: 279, Issue:24, 2004
Early-onset dementia with Lewy bodies.Brain pathology (Zurich, Switzerland), , Volume: 14, Issue:2, 2004
Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease.Neurobiology of disease, , Volume: 16, Issue:1, 2004
SNCA multiplication is not a common cause of Parkinson disease or dementia with Lewy bodies.Neurology, , Aug-10, Volume: 63, Issue:3, 2004
Beta-synuclein gene alterations in dementia with Lewy bodies.Neurology, , Sep-14, Volume: 63, Issue:5, 2004
Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease.Journal of neurochemistry, , Volume: 91, Issue:2, 2004
Lewy body-related alpha-synucleinopathy in the aged human brain.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 111, Issue:10-11, 2004
An antiaggregation gene therapy strategy for Lewy body disease utilizing beta-synuclein lentivirus in a transgenic model.Gene therapy, , Volume: 11, Issue:23, 2004
Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein.FEBS letters, , Oct-22, Volume: 576, Issue:3, 2004
A single amino acid substitution differentiates Hsp70-dependent effects on alpha-synuclein degradation and toxicity.Biochemical and biophysical research communications, , Dec-03, Volume: 325, Issue:1, 2004
Differential expression of alpha-synuclein isoforms in dementia with Lewy bodies.Neuropathology and applied neurobiology, , Volume: 30, Issue:6, 2004
alpha-Synuclein filaments bind the transcriptional regulator HMGB-1.Neuroreport, , Dec-22, Volume: 15, Issue:18, 2004
Abnormal metabotropic glutamate receptor expression and signaling in the cerebral cortex in diffuse Lewy body disease is associated with irregular alpha-synuclein/phospholipase C (PLCbeta1) interactions.Brain pathology (Zurich, Switzerland), , Volume: 14, Issue:4, 2004
Regional distribution of proteinase K-resistant alpha-synuclein correlates with Lewy body disease stage.Journal of neuropathology and experimental neurology, , Volume: 63, Issue:12, 2004
Multiplication of the alpha-synuclein gene is not a common disease mechanism in Lewy body disease.Journal of molecular neuroscience : MN, , Volume: 24, Issue:3, 2004
The Role of alpha-synuclein assembly and metabolism in the pathogenesis of Lewy body disease.Journal of molecular neuroscience : MN, , Volume: 24, Issue:3, 2004
Alpha-synuclein, Abeta and Alzheimer's disease.Progress in neuro-psychopharmacology & biological psychiatry, , Volume: 27, Issue:1, 2003
The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease.Neuron, , Feb-20, Volume: 37, Issue:4, 2003
Alpha-synuclein pathology affecting Bergmann glia of the cerebellum in patients with alpha-synucleinopathies.Acta neuropathologica, , Volume: 105, Issue:4, 2003
Lewy body pathology is a frequent co-pathology in familial Alzheimer's disease.Acta neuropathologica, , Volume: 105, Issue:5, 2003
Colocalization of tau and alpha-synuclein epitopes in Lewy bodies.Journal of neuropathology and experimental neurology, , Volume: 62, Issue:4, 2003
Developmental stages of cortical Lewy bodies and their relation to axonal transport blockage in brains of patients with dementia with Lewy bodies.Journal of the neurological sciences, , Jul-15, Volume: 211, Issue:1-2, 2003
Alpha-synuclein-positive structures in association with diffuse neurofibrillary tangles with calcification.Neuropathology and applied neurobiology, , Volume: 29, Issue:3, 2003
Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease.Neuropharmacology, , Volume: 45, Issue:1, 2003
Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies.The American journal of pathology, , Volume: 163, Issue:1, 2003
Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis.The American journal of pathology, , Volume: 163, Issue:2, 2003
Age-associated prevalence and risk factors of Lewy body pathology in a general population: the Hisayama study.Acta neuropathologica, , Volume: 106, Issue:4, 2003
Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of alpha-synuclein.Brain pathology (Zurich, Switzerland), , Volume: 13, Issue:3, 2003
Neuropathological spectrum of synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 18 Suppl 6, 2003
Alpha-synuclein accumulates in Purkinje cells in Lewy body disease but not in multiple system atrophy.Journal of neuropathology and experimental neurology, , Volume: 62, Issue:8, 2003
Tau pathology in the olfactory bulb correlates with Braak stage, Lewy body pathology and apolipoprotein epsilon4.Neuropathology and applied neurobiology, , Volume: 29, Issue:5, 2003
[Lewy bodies, a misleading marker for Parkinson's disease?].Bulletin de l'Academie nationale de medecine, , Volume: 187, Issue:2, 2003
Neuritic alterations and neural system dysfunction in Alzheimer's disease and dementia with Lewy bodies.Neurochemical research, , Volume: 28, Issue:11, 2003
Cycles of aberrant synaptic sprouting and neurodegeneration in Alzheimer's and dementia with Lewy bodies.Neurochemical research, , Volume: 28, Issue:11, 2003
Glial involvement in diffuse Lewy body disease.Acta neuropathologica, , Volume: 105, Issue:2, 2003
Patterns of protein nitration in dementia with Lewy bodies and striatonigral degeneration.Acta neuropathologica, , Volume: 103, Issue:5, 2002
Progression and staging of Lewy pathology in brains from patients with dementia with Lewy bodies.Journal of the neurological sciences, , Mar-30, Volume: 195, Issue:2, 2002
14-3-3 proteins in Lewy bodies in Parkinson disease and diffuse Lewy body disease brains.Journal of neuropathology and experimental neurology, , Volume: 61, Issue:3, 2002
Familial diffuse Lewy body disease, eye movement abnormalities, and distribution of pathology.Archives of neurology, , Volume: 59, Issue:3, 2002
Relationship in the formation process between neurofibrillary tangles and Lewy bodies in the hippocampus of dementia with Lewy bodies brains.Journal of the neurological sciences, , Mar-15, Volume: 195, Issue:1, 2002
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Monoclonal antibodies against Epstein-Barr virus cross-react with alpha-synuclein in human brain.Neurology, , Nov-14, Volume: 55, Issue:9, 2000
The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.Annals of the New York Academy of Sciences, , Volume: 920, 2000
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Combined CSF α-SYN RT-QuIC, CSF NFL and midbrain-pons planimetry in degenerative parkinsonisms: From bedside to bench, and back again.Parkinsonism & related disorders, , Volume: 99, 2022
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α-synuclein abnormalities trigger focal tau pathology, spreading to various brain areas in Parkinson disease.Journal of neurochemistry, , Volume: 157, Issue:3, 2021
Deposition of Phosphorylated α-Synuclein and Activation of GSK-3β and PP2A in the PS19 Mouse Model of Tauopathy.Journal of neuropathology and experimental neurology, , 09-10, Volume: 80, Issue:8, 2021
In Vivo Diagnosis of Synucleinopathies: A Comparative Study of Skin Biopsy and RT-QuIC.Neurology, , 05-18, Volume: 96, Issue:20, 2021
Bispecific Tau Antibodies with Additional Binding to C1q or Alpha-Synuclein.Journal of Alzheimer's disease : JAD, , Volume: 80, Issue:2, 2021
From Posttranslational Modifications to Disease Phenotype: A Substrate Selection Hypothesis in Neurodegenerative Diseases.International journal of molecular sciences, , Jan-18, Volume: 22, Issue:2, 2021
Multiple Neurodegenerative Pathologies in an Alzheimer's Disease Patient Treated with Fornical Deep Brain Stimulation.Journal of Alzheimer's disease : JAD, , Volume: 80, Issue:4, 2021
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The toxin MPTP generates similar cognitive and locomotor deficits in hTau and tau knock-out mice.Brain research, , 05-15, Volume: 1711, 2019
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Experimental inhibition of fibrillogenesis and neurotoxicity by amyloid-beta (Aβ) and other disease-related peptides/proteins by plant extracts and herbal compounds.Sub-cellular biochemistry, , Volume: 65, 2012
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Targeting α-synuclein aggregation and its role in mitochondrial dysfunction in Parkinson's disease.British journal of pharmacology, , Volume: 179, Issue:1, 2022
Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders.Acta neuropathologica, , Volume: 141, Issue:4, 2021
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Studying the effect of alpha-synuclein and Parkinson's disease linked mutants on inter pathway connectivities.Scientific reports, , 08-11, Volume: 11, Issue:1, 2021
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Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a Communications biology, , Volume: 2, 2019
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Studying Parkinson's disease using Caenorhabditis elegans models in microfluidic devices.Integrative biology : quantitative biosciences from nano to macro, , 05-01, Volume: 11, Issue:5, 2019
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Brain-First versus Gut-First Parkinson's Disease: A Hypothesis.Journal of Parkinson's disease, , Volume: 9, Issue:s2, 2019
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Effect of Electric Field on α-Synuclein Fibrils: Revealed by Molecular Dynamics Simulations.International journal of molecular sciences, , Mar-28, Volume: 24, Issue:7, 2023
Effects of N-terminal Acetylation on the Aggregation of Disease-related α-synuclein Variants.Journal of molecular biology, , 01-15, Volume: 435, Issue:1, 2023
Conformational change of α-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease.Structure (London, England : 1993), , 01-05, Volume: 31, Issue:1, 2023
Small molecule-based fluorescent probes for the detection of α-Synuclein aggregation states.Bioorganic & medicinal chemistry letters, , 04-15, Volume: 86, 2023
α-Synuclein-dependent increases in PIP5K1γ drive inositol signaling to promote neurotoxicity.Cell reports, , 10-31, Volume: 42, Issue:10, 2023
Glycation modulates alpha-synuclein fibrillization kinetics: A sweet spot for inhibition.The Journal of biological chemistry, , Volume: 298, Issue:5, 2022
α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity.Proceedings of the National Academy of Sciences of the United States of America, , 04-12, Volume: 119, Issue:15, 2022
Identification of allosteric fingerprints of alpha-synuclein aggregates in matrix metalloprotease-1 and substrate-specific virtual screening with single molecule insights.Scientific reports, , 04-06, Volume: 12, Issue:1, 2022
The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains.The Journal of biological chemistry, , Volume: 298, Issue:5, 2022
Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases.Progress in neurobiology, , Volume: 214, 2022
Mechanistic insights into accelerated α-synuclein aggregation mediated by human microbiome-associated functional amyloids.The Journal of biological chemistry, , Volume: 298, Issue:7, 2022
Secretagogin is a CaThe Journal of biological chemistry, , Volume: 298, Issue:9, 2022
α-Synuclein Aggregation Intermediates form Fibril Polymorphs with Distinct Prion-like Properties.Journal of molecular biology, , 10-15, Volume: 434, Issue:19, 2022
De novo designed protein inhibitors of amyloid aggregation and seeding.Proceedings of the National Academy of Sciences of the United States of America, , 08-23, Volume: 119, Issue:34, 2022
Liquid-Liquid Phase Separation Promotes Protein Aggregation and Its Implications in Ferroptosis in Parkinson's Disease Dementia.Oxidative medicine and cellular longevity, , Volume: 2022, 2022
Buffering capacity is determinant for restoring early α-synuclein aggregation.Biophysical chemistry, , Volume: 282, 2022
Two-step screening method to identify α-synuclein aggregation inhibitors for Parkinson's disease.Scientific reports, , 01-10, Volume: 12, Issue:1, 2022
Prions and Neurodegenerative Diseases: A Focus on Alzheimer's Disease.Journal of Alzheimer's disease : JAD, , Volume: 85, Issue:2, 2022
Rescue of α-synuclein aggregation in Parkinson's patient neurons by synergistic enhancement of ER proteostasis and protein trafficking.Neuron, , 02-02, Volume: 110, Issue:3, 2022
Immunisation with UB-312 in the Thy1SNCA mouse prevents motor performance deficits and oligomeric α-synuclein accumulation in the brain and gut.Acta neuropathologica, , Volume: 143, Issue:1, 2022
The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity.Molecules (Basel, Switzerland), , Feb-15, Volume: 27, Issue:4, 2022
Neurotoxic or neuroprotective: Post-translational modifications of α-synuclein at the cross-roads of functions.Biochimie, , Volume: 192, 2022
Targeting α-synuclein aggregation and its role in mitochondrial dysfunction in Parkinson's disease.British journal of pharmacology, , Volume: 179, Issue:1, 2022
Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get.Journal of neurochemistry, , Volume: 157, Issue:4, 2021
DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization.PLoS genetics, , Volume: 17, Issue:3, 2021
Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 41, Issue:5, 2021
α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity.Nature communications, , 06-18, Volume: 12, Issue:1, 2021
Vesicle trafficking and lipid metabolism in synucleinopathy.Acta neuropathologica, , Volume: 141, Issue:4, 2021
Preface to an editorial controversy on α-synuclein: How good are cellular models?: This is a Preface for an Editorial controversy between Hilal A. Lashuel "Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complemenJournal of neurochemistry, , Volume: 157, Issue:4, 2021
Detection of pathological alpha-synuclein aggregates in human iPSC-derived neurons and tissue.STAR protocols, , 03-19, Volume: 2, Issue:1, 2021
Alpha-Synuclein Aggregates Associated with Mitochondria in Tunnelling Nanotubes.Neurotoxicity research, , Volume: 39, Issue:2, 2021
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells.Nature communications, , 03-22, Volume: 12, Issue:1, 2021
Phenotypic manifestation of α-synuclein strains derived from Parkinson's disease and multiple system atrophy in human dopaminergic neurons.Nature communications, , 06-21, Volume: 12, Issue:1, 2021
Modulating α-Synuclein Liquid-Liquid Phase Separation.Biochemistry, , 12-07, Volume: 60, Issue:48, 2021
SGTA associates with intracellular aggregates in neurodegenerative diseases.Molecular brain, , 03-23, Volume: 14, Issue:1, 2021
CSPα reduces aggregates and rescues striatal dopamine release in α-synuclein transgenic mice.Brain : a journal of neurology, , 07-28, Volume: 144, Issue:6, 2021
SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration.Biochemical and biophysical research communications, , 05-21, Volume: 554, 2021
Toxic Feedback Loop Involving Iron, Reactive Oxygen Species, α-Synuclein and Neuromelanin in Parkinson's Disease and Intervention with Turmeric.Molecular neurobiology, , Volume: 58, Issue:11, 2021
Physicochemical characterization of the G51D mutation of α-synuclein that is responsible for its severe cytotoxicity.Neuroscience letters, , 08-24, Volume: 760, 2021
C-terminal truncation of α-synuclein alters DNA structure from extension to compaction.Biochemical and biophysical research communications, , 09-03, Volume: 568, 2021
Role of VAPB and vesicular profiles in α-synuclein aggregates in multiple system atrophy.Brain pathology (Zurich, Switzerland), , Volume: 31, Issue:6, 2021
Proteasome Subunits Involved in Neurodegenerative Diseases.Archives of medical research, , Volume: 52, Issue:1, 2021
Structural Features and Toxicity of α-Synuclein Oligomers Grown in the Presence of DOPAC.International journal of molecular sciences, , Jun-02, Volume: 22, Issue:11, 2021
Ageing promotes pathological alpha-synuclein propagation and autonomic dysfunction in wild-type rats.Brain : a journal of neurology, , 07-28, Volume: 144, Issue:6, 2021
Protein Aggregation Landscape in Neurodegenerative Diseases: Clinical Relevance and Future Applications.International journal of molecular sciences, , Jun-02, Volume: 22, Issue:11, 2021
Acupuncture for Parkinson's Disease: Efficacy Evaluation and Mechanisms in the Dopaminergic Neural Circuit.Neural plasticity, , Volume: 2021, 2021
Studying the effect of alpha-synuclein and Parkinson's disease linked mutants on inter pathway connectivities.Scientific reports, , 08-11, Volume: 11, Issue:1, 2021
Wild-type α-synuclein inherits the structure and exacerbated neuropathology of E46K mutant fibril strain by cross-seeding.Proceedings of the National Academy of Sciences of the United States of America, , 05-18, Volume: 118, Issue:20, 2021
The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model.Nature communications, , 08-11, Volume: 12, Issue:1, 2021
The Neural Gut-Brain Axis of Pathological Protein Aggregation in Parkinson's Disease and Its Counterpart in Peroral Prion Infections.Viruses, , 07-18, Volume: 13, Issue:7, 2021
The Intersection of Parkinson's Disease, Viral Infections, and COVID-19.Molecular neurobiology, , Volume: 58, Issue:9, 2021
The Prion-Like Spreading of Alpha-Synuclein in Parkinson's Disease: Update on Models and Hypotheses.International journal of molecular sciences, , Aug-03, Volume: 22, Issue:15, 2021
Monoamine Oxidase-B Inhibition Facilitates α-Synuclein Secretion The Journal of neuroscience : the official journal of the Society for Neuroscience, , 09-01, Volume: 41, Issue:35, 2021
Excess membrane binding of monomeric alpha-, beta- and gamma-synuclein is invariably associated with inclusion formation and toxicity.Human molecular genetics, , 11-16, Volume: 30, Issue:23, 2021
Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates.Journal of neuroinflammation, , Jun-03, Volume: 18, Issue:1, 2021
FRET-Based Screening Identifies p38 MAPK and PKC Inhibition as Targets for Prevention of Seeded α-Synuclein Aggregation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 18, Issue:3, 2021
Lewy body-associated proteins: victims, instigators, or innocent bystanders? The case of AIMP2 and alpha-synuclein.Neurobiology of disease, , Volume: 156, 2021
Influence of Lipid Membranes on α-Synuclein Aggregation.ACS chemical neuroscience, , 03-03, Volume: 12, Issue:5, 2021
In vivo aggregation of presynaptic alpha-synuclein is not influenced by its phosphorylation at serine-129.Neurobiology of disease, , Volume: 152, 2021
Seeded assembly in vitro does not replicate the structures of α-synuclein filaments from multiple system atrophy.FEBS open bio, , Volume: 11, Issue:4, 2021
Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.Chemical reviews, , 02-24, Volume: 121, Issue:4, 2021
Breakdown of supersaturation barrier links protein folding to amyloid formation.Communications biology, , 01-26, Volume: 4, Issue:1, 2021
A protease protection assay for the detection of internalized alpha-synuclein pre-formed fibrils.PloS one, , Volume: 16, Issue:1, 2021
Implementing Complementary Approaches to Shape the Mechanism of α-Synuclein Oligomerization as a Model of Amyloid Aggregation.Molecules (Basel, Switzerland), , Dec-24, Volume: 27, Issue:1, 2021
Ellagic Acid Prevents α-Synuclein Aggregation and Protects SH-SY5Y Cells from Aggregated α-Synuclein-Induced Toxicity via Suppression of Apoptosis and Activation of Autophagy.International journal of molecular sciences, , Dec-13, Volume: 22, Issue:24, 2021
Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson's Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment.Frontiers in immunology, , Volume: 12, 2021
Truncation-Driven Lateral Association of α-Synuclein Hinders Amyloid Clearance by the Hsp70-Based Disaggregase.International journal of molecular sciences, , Nov-30, Volume: 22, Issue:23, 2021
A SUMO1-Derived Peptide Targeting SUMO-Interacting Motif Inhibits α-Synuclein Aggregation.Cell chemical biology, , 02-18, Volume: 28, Issue:2, 2021
(De)stabilization of Alpha-Synuclein Fibrillary Aggregation by Charged and Uncharged Surfactants.International journal of molecular sciences, , Nov-19, Volume: 22, Issue:22, 2021
Polymorphism of Alpha-Synuclein Amyloid Fibrils Depends on Ionic Strength and Protein Concentration.International journal of molecular sciences, , Nov-17, Volume: 22, Issue:22, 2021
Abnormal accumulation of lipid droplets in neurons induces the conversion of alpha-Synuclein to proteolytic resistant forms in a Drosophila model of Parkinson's disease.PLoS genetics, , Volume: 17, Issue:11, 2021
Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo.Neurobiology of disease, , Volume: 151, 2021
Ca2+ administration prevents α-synuclein proteotoxicity by stimulating calcineurin-dependent lysosomal proteolysis.PLoS genetics, , Volume: 17, Issue:11, 2021
Mechanistic Insight from Preclinical Models of Parkinson's Disease Could Help Redirect Clinical Trial Efforts in GDNF Therapy.International journal of molecular sciences, , Oct-28, Volume: 22, Issue:21, 2021
The Bacterial Amyloids Phenol Soluble Modulins from International journal of molecular sciences, , Oct-27, Volume: 22, Issue:21, 2021
Evaluation of blood flow as a route for propagation in experimental synucleinopathy.Neurobiology of disease, , Volume: 150, 2021
14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril model.Acta neuropathologica communications, , 01-07, Volume: 9, Issue:1, 2021
Alpha-Synuclein Antibody Characterization: Why Semantics Matters.Molecular neurobiology, , Volume: 58, Issue:5, 2021
Targeting Microglial α-Synuclein/TLRs/NF-kappaB/NLRP3 Inflammasome Axis in Parkinson's Disease.Frontiers in immunology, , Volume: 12, 2021
How microcompetition with latent viruses can cause α synuclein aggregation, mitochondrial dysfunction, and eventually Parkinson's disease.Journal of neurovirology, , Volume: 27, Issue:1, 2021
DJ-1 Acts as a Scavenger of α-Synuclein Oligomers and Restores Monomeric Glycated α-Synuclein.Biomolecules, , 10-06, Volume: 11, Issue:10, 2021
Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders.Acta neuropathologica, , Volume: 142, Issue:6, 2021
Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model.Molecular neurodegeneration, , 09-09, Volume: 16, Issue:1, 2021
Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy.Journal of cellular and molecular medicine, , Volume: 25, Issue:20, 2021
Papaverine inhibits α-synuclein aggregation by modulating neuroinflammation and matrix metalloproteinase-3 expression in the subacute MPTP/P mouse model of Parkinson's disease.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 130, 2020
Fast kinetics of environmentally induced α-synuclein aggregation mediated by structural alteration in NAC region and result in structure dependent cytotoxicity.Scientific reports, , 10-27, Volume: 10, Issue:1, 2020
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.Scientific reports, , 07-30, Volume: 10, Issue:1, 2020
Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein.Molecular neurodegeneration, , 09-08, Volume: 15, Issue:1, 2020
α-Synuclein aggregation and transmission in Parkinson's disease: a link to mitochondria and lysosome.Science China. Life sciences, , Volume: 63, Issue:12, 2020
Anti-amyloidogenic effect of artemin on α-synuclein.Biological chemistry, , 09-25, Volume: 401, Issue:10, 2020
Copper and iron ions accelerate the prion-like propagation of α-synuclein: A vicious cycle in Parkinson's disease.International journal of biological macromolecules, , Nov-15, Volume: 163, 2020
Eye lens crystallin proteins inhibit the autocatalytic amyloid amplification nature of mature α-synuclein fibrils.PloS one, , Volume: 15, Issue:6, 2020
Structural brain changes in Ser129-phosphorylated alpha-synuclein rats based on voxel-based morphometry.Behavioural brain research, , 09-01, Volume: 393, 2020
Cyclophilin D binds to the acidic C-terminus region of α-Synuclein and affects its aggregation characteristics.Scientific reports, , 06-23, Volume: 10, Issue:1, 2020
Role of alpha-synuclein phosphorylation at Serine 129 in methamphetamine-induced neurotoxicity in vitro and in vivo.Neuroreport, , 08-05, Volume: 31, Issue:11, 2020
A sticky situation: Aberrant protein-protein interactions in Parkinson's disease.Seminars in cell & developmental biology, , Volume: 99, 2020
O-GlcNAcylation inhibits the oligomerization of alpha-synuclein by declining intermolecular hydrogen bonds through a steric effect.Physical biology, , 12-01, Volume: 18, Issue:1, 2020
Phosphorylation and oligomerization of α-synuclein associated with GSK-3β activation in the rTg4510 mouse model of tauopathy.Acta neuropathologica communications, , 06-19, Volume: 8, Issue:1, 2020
TDP-1/TDP-43 potentiates human α-Synuclein (HASN) neurodegeneration in Caenorhabditis elegans.Biochimica et biophysica acta. Molecular basis of disease, , 10-01, Volume: 1866, Issue:10, 2020
Experimental models of prion-like protein propagation.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 40, Issue:5, 2020
Anti-aggregation Effects of Phenolic Compounds on α-synuclein.Molecules (Basel, Switzerland), , May-24, Volume: 25, Issue:10, 2020
The emerging role of α-synuclein truncation in aggregation and disease.The Journal of biological chemistry, , 07-24, Volume: 295, Issue:30, 2020
Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits.Neurobiology of disease, , Volume: 141, 2020
Structural analyses and force fields comparison for NACore (68-78) and SubNACore (69-77) fibril segments of Parkinson's disease.Journal of molecular modeling, , May-12, Volume: 26, Issue:6, 2020
Natural and Synthetic Derivatives of Hydroxycinnamic Acid Modulating the Pathological Transformation of Amyloidogenic Proteins.Molecules (Basel, Switzerland), , Oct-12, Volume: 25, Issue:20, 2020
Polymorphic α-Synuclein Strains Modified by Dopamine and Docosahexaenoic Acid Interact Differentially with Tau Protein.Molecular neurobiology, , Volume: 57, Issue:6, 2020
Do Lewy bodies contain alpha-synuclein fibrils? and Does it matter? A brief history and critical analysis of recent reports.Neurobiology of disease, , Volume: 141, 2020
Biological links between traumatic brain injury and Parkinson's disease.Acta neuropathologica communications, , 04-07, Volume: 8, Issue:1, 2020
Freezing and piercing of in vitro asymmetric plasma membrane by α-synuclein.Communications biology, , 03-31, Volume: 3, Issue:1, 2020
Protein transmission in neurodegenerative disease.Nature reviews. Neurology, , Volume: 16, Issue:4, 2020
Aggregation and Cellular Toxicity of Pathogenic or Non-pathogenic Proteins.Scientific reports, , 03-20, Volume: 10, Issue:1, 2020
The Aggregation Conditions Define Whether EGCG is an Inhibitor or Enhancer of International journal of molecular sciences, , Mar-14, Volume: 21, Issue:6, 2020
Dynamic molecular exchange and conformational transitions of alpha-synuclein at the nano-bio interface.International journal of biological macromolecules, , Jul-01, Volume: 154, 2020
Differential effects of CuBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, , Volume: 33, Issue:2-3, 2020
Initiation and propagation of α-synuclein aggregation in the nervous system.Molecular neurodegeneration, , 03-06, Volume: 15, Issue:1, 2020
Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts.BMC complementary medicine and therapies, , Mar-06, Volume: 20, Issue:1, 2020
Novel fatty acid-binding protein 3 ligand inhibits dopaminergic neuronal death and improves motor and cognitive impairments in Parkinson's disease model mice.Pharmacology, biochemistry, and behavior, , Volume: 191, 2020
Methods for detecting toxic α-synuclein species as a biomarker for Parkinson's disease.Critical reviews in clinical laboratory sciences, , Volume: 57, Issue:5, 2020
Back and to the Future: From Neurotoxin-Induced to Human Parkinson's Disease Models.Current protocols in neuroscience, , Volume: 91, Issue:1, 2020
A new MAP-Rasagiline conjugate reduces α-synuclein inclusion formation in a cell model.Pharmacological reports : PR, , Volume: 72, Issue:2, 2020
Disentangling aggregation-prone proteins: a new method for isolating α-synuclein species: An Editorial Highlight for "A simple, versatile and robust centrifugation-based filtration protocol for the isolation and quantification of α-synuclein monomers, oliJournal of neurochemistry, , Volume: 153, Issue:1, 2020
Alpha-synuclein fragments trigger distinct aggregation pathways.Cell death & disease, , 02-03, Volume: 11, Issue:2, 2020
Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro.Molecules (Basel, Switzerland), , Jan-29, Volume: 25, Issue:3, 2020
N-terminal acetylation mutants affect alpha-synuclein stability, protein levels and neuronal toxicity.Neurobiology of disease, , Volume: 137, 2020
Protein Quality Control Pathways at the Crossroad of Synucleinopathies.Journal of Parkinson's disease, , Volume: 10, Issue:2, 2020
Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4.Journal of immunology (Baltimore, Md. : 1950), , 03-01, Volume: 204, Issue:5, 2020
Scutellarin inhibits the uninduced and metal-induced aggregation of α-Synuclein and disaggregates preformed fibrils: implications for Parkinson's disease.The Biochemical journal, , 02-14, Volume: 477, Issue:3, 2020
A simple, versatile and robust centrifugation-based filtration protocol for the isolation and quantification of α-synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in α-synuclein research.Journal of neurochemistry, , Volume: 153, Issue:1, 2020
Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult.Neuron, , 03-04, Volume: 105, Issue:5, 2020
Diphenyl triazine hybrids inhibit α-synuclein fibrillogenesis: Design, synthesis and in vitro efficacy studies.European journal of medicinal chemistry, , Dec-01, Volume: 207, 2020
Inhibition of synucleinopathic seeding by rationally designed inhibitors.eLife, , 01-02, Volume: 9, 2020
Multiplicity of α-Synuclein Aggregated Species and Their Possible Roles in Disease.International journal of molecular sciences, , Oct-28, Volume: 21, Issue:21, 2020
Interactions between Soluble Species of β-Amyloid and α-Synuclein Promote Oligomerization while Inhibiting Fibrillization.Biochemistry, , 02-04, Volume: 59, Issue:4, 2020
α-Synuclein strains target distinct brain regions and cell types.Nature neuroscience, , Volume: 23, Issue:1, 2020
Preserved proteinase K-resistant core after amplification of alpha-synuclein aggregates: Implication to disease-related structural study.Biochemical and biophysical research communications, , 02-12, Volume: 522, Issue:3, 2020
Insight into the molecular mechanism underlying the inhibition of α-synuclein aggregation by hydroxytyrosol.Biochemical pharmacology, , Volume: 173, 2020
Apoptosis signal regulating kinase 1 deletion mitigates α-synuclein pre-formed fibril propagation in mice.Neurobiology of aging, , Volume: 85, 2020
Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies.Biochimica et biophysica acta. Proteins and proteomics, , Volume: 1868, Issue:1, 2020
What is strain in neurodegenerative diseases?Cellular and molecular life sciences : CMLS, , Volume: 77, Issue:4, 2020
N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of Their Oligomers by the Proteasome Holoenzyme.Journal of molecular biology, , 01-17, Volume: 432, Issue:2, 2020
The Down-Regulation of Clusterin Expression Enhances the αSynuclein Aggregation Process.International journal of molecular sciences, , Sep-29, Volume: 21, Issue:19, 2020
HSP40 proteins use class-specific regulation to drive HSP70 functional diversity.Nature, , Volume: 587, Issue:7834, 2020
Molecular dissection of amyloid disaggregation by human HSP70.Nature, , Volume: 587, Issue:7834, 2020
Alpha-synuclein aggresomes inhibit ciliogenesis and multiple functions of the centrosome.Biology open, , 10-05, Volume: 9, Issue:10, 2020
Gut Microbiome Imbalance and Neuroinflammation: Impact of COVID-19 on Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:9, 2020
Effect of Ionic Strength on Thioflavin-T Affinity to Amyloid Fibrils and Its Fluorescence Intensity.International journal of molecular sciences, , Nov-24, Volume: 21, Issue:23, 2020
Therapeutic genetic variation revealed in diverse Hsp104 homologs.eLife, , 12-15, Volume: 9, 2020
Effect of kaempferol on the transgenic Drosophila model of Parkinson's disease.Scientific reports, , 08-14, Volume: 10, Issue:1, 2020
Polypeptides derived from α-Synuclein binding partners to prevent α-Synuclein fibrils interaction with and take-up by cells.PloS one, , Volume: 15, Issue:8, 2020
On the role of the cellular prion protein in the uptake and signaling of pathological aggregates in neurodegenerative diseases.Prion, , Volume: 14, Issue:1, 2020
Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions.Acta neuropathologica communications, , 08-12, Volume: 8, Issue:1, 2020
The Toxicity of Misfolded Protein Oligomers Is Independent of Their Secondary Structure.ACS chemical biology, , 07-19, Volume: 14, Issue:7, 2019
Detection of Misfolded α-Synuclein Aggregates in Cerebrospinal Fluid by the Protein Misfolding Cyclic Amplification Platform.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
Stereotaxic Targeting of Alpha-Synuclein Pathology in Mouse Brain Using Preformed Fibrils.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
Alpha-Synuclein Proximity Ligation Assay (AS-PLA) in Brain Sections to Probe for Alpha-Synuclein Oligomers.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
Rosmarinic acid protects against MPTP-induced toxicity and inhibits iron-induced α-synuclein aggregation.Neuropharmacology, , Volume: 144, 2019
Single-Molecule FRET Detection of Early-Stage Conformations in α-Synuclein Aggregation.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
Early stages of aggregation of engineered α-synuclein monomers and oligomers in solution.Scientific reports, , 02-11, Volume: 9, Issue:1, 2019
Necrosis, apoptosis, necroptosis, three modes of action of dopaminergic neuron neurotoxins.PloS one, , Volume: 14, Issue:4, 2019
Toward the discovery and development of effective modulators of α-synuclein amyloid aggregation.European journal of medicinal chemistry, , Apr-01, Volume: 167, 2019
The role of lipids in α-synuclein misfolding and neurotoxicity.The Journal of biological chemistry, , 06-07, Volume: 294, Issue:23, 2019
Abundance of Synaptic Vesicle-Related Proteins in Alpha-Synuclein-Containing Protein Inclusions Suggests a Targeted Formation Mechanism.Neurotoxicity research, , Volume: 35, Issue:4, 2019
Naturally occurring antibodies isolated from PD patients inhibit synuclein seeding in vitro and recognize Lewy pathology.Acta neuropathologica, , Volume: 137, Issue:5, 2019
Cyclized NDGA modifies dynamic α-synuclein monomers preventing aggregation and toxicity.Scientific reports, , 02-27, Volume: 9, Issue:1, 2019
Effects of alpha-synuclein post-translational modifications on metal binding.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
C-terminal α-synuclein truncations are linked to cysteine cathepsin activity in Parkinson's disease.The Journal of biological chemistry, , 06-21, Volume: 294, Issue:25, 2019
Naturally occurring autoantibodies against α-synuclein rescues memory and motor deficits and attenuates α-synuclein pathology in mouse model of Parkinson's disease.Neurobiology of disease, , Volume: 124, 2019
Heterogeneity in gut microbiota drive polyphenol metabolism that influences α-synuclein misfolding and toxicity.The Journal of nutritional biochemistry, , Volume: 64, 2019
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Disruptive membrane interactions of alpha-synuclein aggregates.Biochimica et biophysica acta. Proteins and proteomics, , Volume: 1867, Issue:5, 2019
Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein.Science signaling, , 03-12, Volume: 12, Issue:572, 2019
How is alpha-synuclein cleared from the cell?Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates.Acta neuropathologica communications, , 12-19, Volume: 7, Issue:1, 2019
Viral mimetic priming enhances α-synuclein-induced degeneration: Implications for Parkinson's disease.Brain, behavior, and immunity, , Volume: 80, 2019
Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts.Nature communications, , 12-04, Volume: 10, Issue:1, 2019
Increased Dynamics of α-Synuclein Fibrils by β-Synuclein Leads to Reduced Seeding and Cytotoxicity.Scientific reports, , 11-26, Volume: 9, Issue:1, 2019
Patient-specific pluripotent stem cell-based Parkinson's disease models showing endogenous alpha-synuclein aggregation.BMB reports, , Volume: 52, Issue:6, 2019
Small molecule modulator of aggrephagy regulates neuroinflammation to curb pathogenesis of neurodegeneration.EBioMedicine, , Volume: 50, 2019
Binding of Noradrenaline to Native and Intermediate States during the Fibrillation of α-Synuclein Leads to the Formation of Stable and Structured Cytotoxic Species.ACS chemical neuroscience, , 06-19, Volume: 10, Issue:6, 2019
Different Effects of α-Synuclein Mutants on Lipid Binding and Aggregation Detected by Single Molecule Fluorescence Spectroscopy and ThT Fluorescence-Based Measurements.ACS chemical neuroscience, , 03-20, Volume: 10, Issue:3, 2019
Modulation of α-Synuclein Aggregation by Cytochrome c Binding and Hetero-dityrosine Adduct Formation.ACS chemical neuroscience, , 03-20, Volume: 10, Issue:3, 2019
Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs.Nature structural & molecular biology, , Volume: 26, Issue:11, 2019
Seeded propagation of α-synuclein aggregation in mouse brain using protein misfolding cyclic amplification.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 33, Issue:11, 2019
LRRK2 modifies α-syn pathology and spread in mouse models and human neurons.Acta neuropathologica, , Volume: 137, Issue:6, 2019
Alpha-synuclein stepwise aggregation reveals features of an early onset mutation in Parkinson's disease.Communications biology, , Volume: 2, 2019
Secretagogin Binding Prevents α-Synuclein Fibrillation.Biochemistry, , 11-19, Volume: 58, Issue:46, 2019
α-Synuclein (αSyn) Preformed Fibrils Induce Endogenous αSyn Aggregation, Compromise Synaptic Activity and Enhance Synapse Loss in Cultured Excitatory Hippocampal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 06-26, Volume: 39, Issue:26, 2019
The effect of mutant GBA1 on accumulation and aggregation of α-synuclein.Human molecular genetics, , 06-01, Volume: 28, Issue:11, 2019
A small molecule autophagy inducer exerts cytoprotection against α-synuclein toxicity.European journal of pharmacology, , Nov-05, Volume: 862, 2019
Early Stage Alpha-Synuclein Amyloid Fibrils are Reservoirs of Membrane-Binding Species.Scientific reports, , 02-11, Volume: 9, Issue:1, 2019
Loss of One Engrailed1 Allele Enhances Induced α-Synucleinopathy.Journal of Parkinson's disease, , Volume: 9, Issue:2, 2019
A secret that underlies Parkinson's disease: The damaging cycle.Neurochemistry international, , Volume: 129, 2019
N-Terminal Acetylation Affects α-Synuclein Fibril Polymorphism.Biochemistry, , 09-03, Volume: 58, Issue:35, 2019
Complex of EGCG with Cu(II) Suppresses Amyloid Aggregation and Cu(II)-Induced Cytotoxicity of α-Synuclein.Molecules (Basel, Switzerland), , Aug-14, Volume: 24, Issue:16, 2019
Alpha-synuclein at the nexus of genes and environment: the impact of environmental enrichment and stress on brain health and disease.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Alzheimer's disease and other neurodegenerative dementias in comorbidity: A clinical and neuropathological overview.Clinical biochemistry, , Volume: 73, 2019
Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model.Acta neuropathologica, , Volume: 138, Issue:4, 2019
Dynamic behaviors of α-synuclein and tau in the cellular context: New mechanistic insights and therapeutic opportunities in neurodegeneration.Neurobiology of disease, , Volume: 132, 2019
α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 01-29, Volume: 116, Issue:5, 2019
In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategies.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils.eLife, , 08-21, Volume: 8, 2019
Antibodies against alpha-synuclein: tools and therapies.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases.Neurology, , 02-12, Volume: 92, Issue:7, 2019
Identification of a New α-Synuclein Aggregation Inhibitor via Mass Spectrometry Based Screening.ACS chemical neuroscience, , 06-19, Volume: 10, Issue:6, 2019
Modeling Parkinson's disease in adult Drosophila.Journal of neuroscience methods, , 01-01, Volume: 311, 2019
[Prion-like Propagation of Pathological α-Synuclein in Vivo].Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, , Volume: 139, Issue:7, 2019
[Real-time Quaking-induced Conversion Analysis of Prion-like Seeding Activity of Pathological α-Synuclein].Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, , Volume: 139, Issue:7, 2019
Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity.Redox biology, , Volume: 22, 2019
Cellular models of alpha-synuclein toxicity and aggregation.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose.Scientific reports, , 01-24, Volume: 9, Issue:1, 2019
Glial α-synuclein promotes neurodegeneration characterized by a distinct transcriptional program in vivo.Glia, , Volume: 67, Issue:10, 2019
The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy.Biochimica et biophysica acta. Molecular basis of disease, , 11-01, Volume: 1865, Issue:11, 2019
Arylsulfatase A, a genetic modifier of Parkinson's disease, is an α-synuclein chaperone.Brain : a journal of neurology, , 09-01, Volume: 142, Issue:9, 2019
Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation.Cell death and differentiation, , Volume: 26, Issue:9, 2019
Interplay between α-synuclein amyloid formation and membrane structure.Biochimica et biophysica acta. Proteins and proteomics, , Volume: 1867, Issue:5, 2019
Assays for Neuronal Defects Caused by Early Formation of α-Synuclein Inclusions in Primary Cultured Neurons.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term.Acta neuropathologica, , Volume: 135, Issue:1, 2018
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells.Chembiochem : a European journal of chemical biology, , 10-04, Volume: 19, Issue:19, 2018
Sequestration of synaptic proteins by alpha-synuclein aggregates leading to neurotoxicity is inhibited by small peptide.PloS one, , Volume: 13, Issue:4, 2018
MicroRNA-7 facilitates the degradation of alpha-synuclein and its aggregates by promoting autophagy.Neuroscience letters, , 06-21, Volume: 678, 2018
Iron promotes α-synuclein aggregation and transmission by inhibiting TFEB-mediated autophagosome-lysosome fusion.Journal of neurochemistry, , Volume: 145, Issue:1, 2018
Toxic properties of microsome-associated alpha-synuclein species in mouse primary neurons.Neurobiology of disease, , Volume: 111, 2018
Real-time determination of aggregated alpha-synuclein induced membrane disruption at neuroblastoma cells using scanning ion conductance microscopy.Faraday discussions, , 10-01, Volume: 210, Issue:0, 2018
Esterification of PQQ Enhances Blood-Brain Barrier Permeability and Inhibitory Activity against Amyloidogenic Protein Fibril Formation.ACS chemical neuroscience, , 12-19, Volume: 9, Issue:12, 2018
Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons.Proceedings of the National Academy of Sciences of the United States of America, , 10-09, Volume: 115, Issue:41, 2018
"Cell-addictive" dual-target traceable nanodrug for Parkinson's disease treatment via flotillins pathway.Theranostics, , Volume: 8, Issue:19, 2018
Skin α-synuclein deposits differ in clinical variants of synucleinopathy: an in vivo study.Scientific reports, , 09-24, Volume: 8, Issue:1, 2018
Targeting of Disordered Proteins by Small Molecules in Neurodegenerative Diseases.Handbook of experimental pharmacology, , Volume: 245, 2018
Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale.Nano letters, , 12-12, Volume: 18, Issue:12, 2018
Quinolinic Acid Amyloid-like Fibrillar Assemblies Seed α-Synuclein Aggregation.Journal of molecular biology, , 10-12, Volume: 430, Issue:20, 2018
Deposition of Phosphorylated α-Synuclein in the rTg4510 Mouse Model of Tauopathy.Journal of neuropathology and experimental neurology, , 10-01, Volume: 77, Issue:10, 2018
Identification of an Alternatively Spliced α-Synuclein Isoform That Generates a 41-Amino Acid N-Terminal Truncated Peptide, 41-syn: Role in Dopamine Homeostasis.ACS chemical neuroscience, , 12-19, Volume: 9, Issue:12, 2018
Role of Sporadic Parkinson Disease Associated Mutations A18T and A29S in Enhanced α-Synuclein Fibrillation and Cytotoxicity.ACS chemical neuroscience, , 02-21, Volume: 9, Issue:2, 2018
Soluble Epoxide Hydrolase Inhibition Attenuates MPTP-Induced Neurotoxicity in the Nigrostriatal Dopaminergic System: Involvement of α-Synuclein Aggregation and ER Stress.Molecular neurobiology, , Volume: 55, Issue:1, 2018
The Familial α-Synuclein A53E Mutation Enhances Cell Death in Response to Environmental Toxins Due to a Larger Population of Oligomers.Biochemistry, , 08-21, Volume: 57, Issue:33, 2018
Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in α-Synuclein Aggregation Disorders.EBioMedicine, , Volume: 31, 2018
Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity.Acta neuropathologica, , Volume: 135, Issue:6, 2018
Distinct α-Synuclein strains and implications for heterogeneity among α-Synucleinopathies.Neurobiology of disease, , Volume: 109, Issue:Pt B, 2018
Chaperone AMPylation modulates aggregation and toxicity of neurodegenerative disease-associated polypeptides.Proceedings of the National Academy of Sciences of the United States of America, , 05-29, Volume: 115, Issue:22, 2018
Seipin deficiency in mice causes loss of dopaminergic neurons via aggregation and phosphorylation of α-synuclein and neuroinflammation.Cell death & disease, , 05-01, Volume: 9, Issue:5, 2018
Paradoxical Effect of Trehalose on the Aggregation of α-Synuclein: Expedites Onset of Aggregation yet Reduces Fibril Load.ACS chemical neuroscience, , 06-20, Volume: 9, Issue:6, 2018
Graphene quantum dots prevent α-synucleinopathy in Parkinson's disease.Nature nanotechnology, , Volume: 13, Issue:9, 2018
Lack of pathogenic potential of peripheral α-synuclein aggregates from Parkinson's disease patients.Acta neuropathologica communications, , 02-08, Volume: 6, Issue:1, 2018
Cerebral inoculation of human A53T α-synuclein reduces spatial memory decline and amyloid-β aggregation in APP/PS1 transgenic mice of Alzheimer's disease.Brain research bulletin, , Volume: 143, 2018
DNAJC12: A molecular chaperone involved in proteostasis, PKU, biogenic amines metabolism and beyond?Molecular genetics and metabolism, , Volume: 123, Issue:3, 2018
Computational investigation on the effects of H50Q and G51D mutations on the α-Synuclein aggregation propensity.Journal of biomolecular structure & dynamics, , Volume: 36, Issue:9, 2018
Effects of different force fields on the structural character of α synuclein β-hairpin peptide (35-56) in aqueous environment.Journal of biomolecular structure & dynamics, , Volume: 36, Issue:2, 2018
Neuronal complex I deficiency occurs throughout the Parkinson's disease brain, but is not associated with neurodegeneration or mitochondrial DNA damage.Acta neuropathologica, , Volume: 135, Issue:3, 2018
Physiological C-terminal truncation of α-synuclein potentiates the prion-like formation of pathological inclusions.The Journal of biological chemistry, , 12-07, Volume: 293, Issue:49, 2018
Isolated nigral degeneration without pathological protein aggregation in autopsied brains with LRRK2 p.R1441H homozygous and heterozygous mutations.Acta neuropathologica communications, , 10-17, Volume: 6, Issue:1, 2018
Modeling Parkinson's Disease in C. elegans.Journal of Parkinson's disease, , Volume: 8, Issue:1, 2018
The effect of truncation on prion-like properties of α-synuclein.The Journal of biological chemistry, , 09-07, Volume: 293, Issue:36, 2018
Insights into the Molecular Mechanisms of Alzheimer's and Parkinson's Diseases with Molecular Simulations: Understanding the Roles of Artificial and Pathological Missense Mutations in Intrinsically Disordered Proteins Related to Pathology.International journal of molecular sciences, , Jan-24, Volume: 19, Issue:2, 2018
Unveiling a Selective Mechanism for the Inhibition of α-Synuclein Aggregation by β-Synuclein.International journal of molecular sciences, , Jan-24, Volume: 19, Issue:2, 2018
Local and Global Dynamics in Intrinsically Disordered Synuclein.Angewandte Chemie (International ed. in English), , 11-12, Volume: 57, Issue:46, 2018
Complexation of NAC-Derived Peptide Ligands with the C-Terminus of α-Synuclein Accelerates Its Aggregation.Biochemistry, , 02-06, Volume: 57, Issue:5, 2018
Multi-Pronged Interactions Underlie Inhibition of α-Synuclein Aggregation by β-Synuclein.Journal of molecular biology, , 08-03, Volume: 430, Issue:16, 2018
Prion-like propagation of pathology in Parkinson disease.Handbook of clinical neurology, , Volume: 153, 2018
Exogenous α-synuclein hinders synaptic communication in cultured cortical primary rat neurons.PloS one, , Volume: 13, Issue:3, 2018
Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils.Proceedings of the National Academy of Sciences of the United States of America, , 07-10, Volume: 115, Issue:28, 2018
miR-486-3p Influences the Neurotoxicity of a-Synuclein by Targeting the SIRT2 Gene and the Polymorphisms at Target Sites Contributing to Parkinson's Disease.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , Volume: 51, Issue:6, 2018
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.ACS chemical biology, , 08-17, Volume: 13, Issue:8, 2018
Release and uptake of pathologic alpha-synuclein.Cell and tissue research, , Volume: 373, Issue:1, 2018
C-terminal truncation exacerbates the aggregation and cytotoxicity of α-Synuclein: A vicious cycle in Parkinson's disease.Biochimica et biophysica acta. Molecular basis of disease, , Volume: 1864, Issue:12, 2018
Lipid vesicles affect the aggregation of 4-hydroxy-2-nonenal-modified α-synuclein oligomers.Biochimica et biophysica acta. Molecular basis of disease, , Volume: 1864, Issue:9 Pt B, 2018
The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson's disease.Scientific reports, , 11-01, Volume: 8, Issue:1, 2018
LncRNA SNHG1 promotes α-synuclein aggregation and toxicity by targeting miR-15b-5p to activate SIAH1 in human neuroblastoma SH-SY5Y cells.Neurotoxicology, , Volume: 68, 2018
Nrf2 mitigates LRRK2- and α-synuclein-induced neurodegeneration by modulating proteostasis.Proceedings of the National Academy of Sciences of the United States of America, , 01-31, Volume: 114, Issue:5, 2017
Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice.Scientific reports, , 11-28, Volume: 7, Issue:1, 2017
Polyphenols in combination with β-cyclodextrin can inhibit and disaggregate α-synuclein amyloids under cell mimicking conditions: A promising therapeutic alternative.Biochimica et biophysica acta. Proteins and proteomics, , Volume: 1865, Issue:5, 2017
Antibodies against the C-terminus of α-synuclein modulate its fibrillation.Biophysical chemistry, , Volume: 220, 2017
Potential Modes of Intercellular α-Synuclein Transmission.International journal of molecular sciences, , Feb-22, Volume: 18, Issue:2, 2017
Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models.Proceedings of the National Academy of Sciences of the United States of America, , 03-07, Volume: 114, Issue:10, 2017
DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function.Scientific reports, , 01-13, Volume: 7, 2017
Homogentisic acid induces aggregation and fibrillation of amyloidogenic proteins.Biochimica et biophysica acta. General subjects, , Volume: 1861, Issue:2, 2017
Expanding role of molecular chaperones in regulating α-synuclein misfolding; implications in Parkinson's disease.Cellular and molecular life sciences : CMLS, , Volume: 74, Issue:4, 2017
Familial Mutations May Switch Conformational Preferences in α-Synuclein Fibrils.ACS chemical neuroscience, , 04-19, Volume: 8, Issue:4, 2017
MicroRNA expressing profiles in A53T mutant alpha-synuclein transgenic mice and Parkinsonian.Oncotarget, , Jan-03, Volume: 8, Issue:1, 2017
Is trehalose an autophagic inducer? Unraveling the roles of non-reducing disaccharides on autophagic flux and alpha-synuclein aggregation.Cell death & disease, , 10-05, Volume: 8, Issue:10, 2017
Opposed Effects of Dityrosine Formation in Soluble and Aggregated α-Synuclein on Fibril Growth.Journal of molecular biology, , 10-13, Volume: 429, Issue:20, 2017
Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells.Scientific reports, , 09-13, Volume: 7, Issue:1, 2017
Protein arginylation targets alpha synuclein, facilitates normal brain health, and prevents neurodegeneration.Scientific reports, , 09-12, Volume: 7, Issue:1, 2017
E46K α-synuclein pathological mutation causes cell-autonomous toxicity without altering protein turnover or aggregation.Proceedings of the National Academy of Sciences of the United States of America, , 09-26, Volume: 114, Issue:39, 2017
Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity.Acta neuropathologica communications, , 01-10, Volume: 5, Issue:1, 2017
The Medicinal Chemistry of Natural and Semisynthetic Compounds against Parkinson's and Huntington's Diseases.ACS chemical neuroscience, , 11-15, Volume: 8, Issue:11, 2017
Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils.Redox biology, , Volume: 11, 2017
Analysis of sheep α-synuclein provides a molecular strategy for the reduction of fibrillation.Biochimica et biophysica acta. Proteins and proteomics, , Volume: 1865, Issue:3, 2017
Synucleinopathies: common features and hippocampal manifestations.Cellular and molecular life sciences : CMLS, , Volume: 74, Issue:8, 2017
Alpha-synuclein oligomers: a new hope.Acta neuropathologica, , Volume: 134, Issue:6, 2017
Following the fate of endocytosed fibrils.The Journal of biological chemistry, , 08-11, Volume: 292, Issue:32, 2017
Preclinical development of a vaccine against oligomeric alpha-synuclein based on virus-like particles.PloS one, , Volume: 12, Issue:8, 2017
Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates.Scientific reports, , 08-09, Volume: 7, Issue:1, 2017
Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation.Biochemical Society transactions, , 02-08, Volume: 45, Issue:1, 2017
Distinct Mechanisms Determine α-Synuclein Fibril Morphology during Growth and Maturation.ACS chemical neuroscience, , 03-15, Volume: 8, Issue:3, 2017
Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils.Journal of virology, , Jan-15, Volume: 91, Issue:2, 2017
Modulation of the extent of structural heterogeneity in α-synuclein fibrils by the small molecule thioflavin T.The Journal of biological chemistry, , 10-13, Volume: 292, Issue:41, 2017
α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation.Proceedings of the National Academy of Sciences of the United States of America, , 01-31, Volume: 114, Issue:5, 2017
Alteration of Structure and Aggregation of α-Synuclein by Familial Parkinson's Disease Associated Mutations.Current protein & peptide science, , Volume: 18, Issue:7, 2017
The relevance of contact-independent cell-to-cell transfer of TDP-43 and SOD1 in amyotrophic lateral sclerosis.Biochimica et biophysica acta. Molecular basis of disease, , Volume: 1863, Issue:11, 2017
Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form.Neurobiology of disease, , Volume: 106, 2017
A pH-dependent switch promotes β-synuclein fibril formation via glutamate residues.The Journal of biological chemistry, , 09-29, Volume: 292, Issue:39, 2017
Physico-Pathologic Mechanisms Involved in Neurodegeneration: Misfolded Protein-Plasma Membrane Interactions.Neuron, , Jul-05, Volume: 95, Issue:1, 2017
Parkinson's Disease: Basic Pathomechanisms and a Clinical Overview.Advances in neurobiology, , Volume: 15, 2017
S-nitrosylation of UCHL1 induces its structural instability and promotes α-synuclein aggregation.Scientific reports, , 03-16, Volume: 7, 2017
Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease.Nature structural & molecular biology, , Volume: 24, Issue:8, 2017
The Role of Lipids Interacting with α-Synuclein in the Pathogenesis of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 7, Issue:3, 2017
Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration.Brain : a journal of neurology, , Volume: 140, Issue:2, 2017
Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species.Scientific reports, , 02-03, Volume: 7, 2017
Human cyclophilin 40 unravels neurotoxic amyloids.PLoS biology, , Volume: 15, Issue:6, 2017
Detection and Characterization of Small Molecule Interactions with Fibrillar Protein Aggregates Using Microscale Thermophoresis.ACS chemical neuroscience, , 09-20, Volume: 8, Issue:9, 2017
Deferiprone Rescues Behavioral Deficits Induced by Mild Iron Exposure in a Mouse Model of Alpha-Synuclein Aggregation.Neuromolecular medicine, , Volume: 19, Issue:2-3, 2017
Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates.Acta neuropathologica communications, , 06-15, Volume: 5, Issue:1, 2017
Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies.The Journal of biological chemistry, , 08-11, Volume: 292, Issue:32, 2017
Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology.Acta neuropathologica communications, , 06-09, Volume: 5, Issue:1, 2017
Protein aggregation and neurodegeneration in prototypical neurodegenerative diseases: Examples of amyloidopathies, tauopathies and synucleinopathies.Progress in neurobiology, , Volume: 155, 2017
Distinct pattern of enteric phospho-alpha-synuclein aggregates and gene expression profiles in patients with Parkinson's disease.Acta neuropathologica communications, , 01-05, Volume: 5, Issue:1, 2017
Propagation of pathological α-synuclein in marmoset brain.Acta neuropathologica communications, , Feb-02, Volume: 5, Issue:1, 2017
Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production.Cellular and molecular life sciences : CMLS, , Volume: 74, Issue:15, 2017
High expression levels of the D686N Parkinson's disease mutation in VPS35 induces α-synuclein-dependent toxicity in yeast.Molecular medicine reports, , Volume: 16, Issue:1, 2017
Differential copper binding to alpha-synuclein and its disease-associated mutants affect the aggregation and amyloid formation.Biochimica et biophysica acta. General subjects, , Volume: 1861, Issue:2, 2017
Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid.JAMA neurology, , Feb-01, Volume: 74, Issue:2, 2017
An ortho-Iminoquinone Compound Reacts with Lysine Inhibiting Aggregation while Remodeling Mature Amyloid Fibrils.ACS chemical neuroscience, , 08-16, Volume: 8, Issue:8, 2017
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.Proceedings of the National Academy of Sciences of the United States of America, , 02-07, Volume: 114, Issue:6, 2017
Acrolein acts as a neurotoxin in the nigrostriatal dopaminergic system of rat: involvement of α-synuclein aggregation and programmed cell death.Scientific reports, , 04-12, Volume: 7, 2017
Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.Brain : a journal of neurology, , May-01, Volume: 140, Issue:5, 2017
Amplification of distinct α-synuclein fibril conformers through protein misfolding cyclic amplification.Experimental & molecular medicine, , 04-07, Volume: 49, Issue:4, 2017
A sensitive assay reveals structural requirements for α-synuclein fibril growth.The Journal of biological chemistry, , 06-02, Volume: 292, Issue:22, 2017
A novel pathway for amyloids self-assembly in aggregates at nanomolar concentration mediated by the interaction with surfaces.Scientific reports, , 03-30, Volume: 7, 2017
Seeding and transgenic overexpression of alpha-synuclein triggers dendritic spine pathology in the neocortex.EMBO molecular medicine, , Volume: 9, Issue:5, 2017
A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity.Autophagy, , Jul-03, Volume: 13, Issue:7, 2017
Insulin resistance and exendin-4 treatment for multiple system atrophy.Brain : a journal of neurology, , May-01, Volume: 140, Issue:5, 2017
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers.Science (New York, N.Y.), , 12-15, Volume: 358, Issue:6369, 2017
α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies.Nature medicine, , Feb-07, Volume: 23, Issue:2, 2017
Histones facilitate α-synuclein aggregation during neuronal apoptosis.Acta neuropathologica, , Volume: 133, Issue:4, 2017
Structural variants in SNCA gene and the implication to synucleinopathies.Current opinion in genetics & development, , Volume: 44, 2017
Evidence for Intramolecular Antiparallel Beta-Sheet Structure in Alpha-Synuclein Fibrils from a Combination of Two-Dimensional Infrared Spectroscopy and Atomic Force Microscopy.Scientific reports, , 01-23, Volume: 7, 2017
Common structural features of toxic intermediates from α-synuclein and GroES fibrillogenesis detected using cryogenic coherent X-ray diffraction imaging.Journal of biochemistry, , Volume: 161, Issue:1, 2017
Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 11-01, Volume: 113, Issue:44, 2016
Caspase-1 clipping causes complications for α-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , Sep-06, Volume: 113, Issue:36, 2016
α-Synuclein is a Novel Microtubule Dynamase.Scientific reports, , 09-15, Volume: 6, 2016
An 11-mer Amyloid Beta Peptide Fragment Provokes Chemical Mutations and Parkinsonian Biomarker Aggregation in Dopaminergic Cells: A Novel Road Map for "Transfected" Parkinson's.ACS chemical neuroscience, , 11-16, Volume: 7, Issue:11, 2016
α-Synuclein Fibrils Exhibit Gain of Toxic Function, Promoting Tau Aggregation and Inhibiting Microtubule Assembly.The Journal of biological chemistry, , 07-15, Volume: 291, Issue:29, 2016
Suppression of amyloid fibrils using the GroEL apical domain.Scientific reports, , 08-04, Volume: 6, 2016
Interactions of GFAP with ceftriaxone and phenytoin: SRCD and molecular docking and dynamic simulation.Biochimica et biophysica acta, , Volume: 1860, Issue:10, 2016
A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death.Human molecular genetics, , 07-15, Volume: 25, Issue:14, 2016
Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons.Proceedings of the National Academy of Sciences of the United States of America, , 07-26, Volume: 113, Issue:30, 2016
Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , 06-28, Volume: 113, Issue:26, 2016
Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.Proceedings of the National Academy of Sciences of the United States of America, , 10-18, Volume: 113, Issue:42, 2016
Nanomolar oligomerization and selective co-aggregation of α-synuclein pathogenic mutants revealed by single-molecule fluorescence.Scientific reports, , 11-28, Volume: 6, 2016
Cyclodextrins 3-Functionalized with 8-Hydroxyquinolines: Copper-Binding Ability and Inhibition of Synuclein Aggregation.Chemistry, an Asian journal, , Sep-06, Volume: 11, Issue:17, 2016
Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans.Scientific reports, , 10-06, Volume: 6, 2016
High-content analysis of α-synuclein aggregation and cell death in a cellular model of Parkinson's disease.Journal of neuroscience methods, , Mar-01, Volume: 261, 2016
Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration.PLoS genetics, , Volume: 12, Issue:3, 2016
Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation.Proceedings of the National Academy of Sciences of the United States of America, , 09-13, Volume: 113, Issue:37, 2016
Nanomechanical properties of distinct fibrillar polymorphs of the protein α-synuclein.Scientific reports, , 11-30, Volume: 6, 2016
Delivery of Dual Drug Loaded Lipid Based Nanoparticles across the Blood-Brain Barrier Impart Enhanced Neuroprotection in a Rotenone Induced Mouse Model of Parkinson's Disease.ACS chemical neuroscience, , 12-21, Volume: 7, Issue:12, 2016
A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration.Nature reviews. Neuroscience, , Volume: 17, Issue:4, 2016
Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons.Proceedings of the National Academy of Sciences of the United States of America, , Apr-05, Volume: 113, Issue:14, 2016
Clioquinol Improves Cognitive, Motor Function, and Microanatomy of the Alpha-Synuclein hA53T Transgenic Mice.ACS chemical neuroscience, , Jan-20, Volume: 7, Issue:1, 2016
Silica-coated magnetic nanoparticles impair proteasome activity and increase the formation of cytoplasmic inclusion bodies in vitro.Scientific reports, , 07-05, Volume: 6, 2016
Up-regulation of SNCA gene expression: implications to synucleinopathies.Neurogenetics, , Volume: 17, Issue:3, 2016
Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson's disease.The Journal of experimental medicine, , 08-22, Volume: 213, Issue:9, 2016
Copper Binding and Subsequent Aggregation of α-Synuclein Are Modulated by N-Terminal Acetylation and Ablated by the H50Q Missense Mutation.Biochemistry, , 08-30, Volume: 55, Issue:34, 2016
Structural remodeling during amyloidogenesis of physiological Nα-acetylated α-synuclein.Biochimica et biophysica acta, , Volume: 1864, Issue:5, 2016
Stabilization of α-Synuclein Fibril Clusters Prevents Fragmentation and Reduces Seeding Activity and Toxicity.Biochemistry, , Feb-02, Volume: 55, Issue:4, 2016
Acupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain.Scientific reports, , Jan-21, Volume: 6, 2016
Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease.Antioxidants & redox signaling, , Mar-01, Volume: 24, Issue:7, 2016
Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains.Journal of visualized experiments : JoVE, , Jan-05, Issue:107, 2016
Detection of Helical Intermediates During Amyloid Formation by Intrinsically Disordered Polypeptides and Proteins.Methods in molecular biology (Clifton, N.J.), , Volume: 1345, 2016
Phosphorylation induces distinct alpha-synuclein strain formation.Scientific reports, , 11-17, Volume: 6, 2016
Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization.The Journal of biological chemistry, , Feb-26, Volume: 291, Issue:9, 2016
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Unraveling the role of hydrogen peroxide in α-synuclein aggregation using an ultrasensitive nanoplasmonic probe.Analytical chemistry, , Feb-03, Volume: 87, Issue:3, 2015
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miR-101a-3p Impairs Synaptic Plasticity and Contributes to Synucleinopathy.Journal of Parkinson's disease, , Volume: 13, Issue:2, 2023
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New SNCA mutation and structures of α-synuclein filaments from juvenile-onset synucleinopathy.Acta neuropathologica, , Volume: 145, Issue:5, 2023
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RAGE Against the Glycation Machine in Synucleinopathies: Time to Explore New Questions.Journal of Parkinson's disease, , Volume: 13, Issue:5, 2023
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Single-dose intranasal administration of α-syn PFFs induce lewy neurite-like pathology in olfactory bulbs.Parkinsonism & related disorders, , Volume: 112, 2023
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Alpha-synuclein fibrils amplified from multiple system atrophy and Parkinson's disease patient brain spread after intracerebral injection into mouse brain.Brain pathology (Zurich, Switzerland), , Volume: 33, Issue:5, 2023
The c-Abl inhibitor IkT-148009 suppresses neurodegeneration in mouse models of heritable and sporadic Parkinson's disease.Science translational medicine, , 01-18, Volume: 15, Issue:679, 2023
Stabilization of 14-3-3 protein-protein interactions with Fusicoccin-A decreases alpha-synuclein dependent cell-autonomous death in neuronal and mouse models.Neurobiology of disease, , Volume: 183, 2023
Serotonin in synucleinopathies.Behavioural brain research, , 05-08, Volume: 445, 2023
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α-Synuclein Strains and Their Relevance to Parkinson's Disease, Multiple System Atrophy, and Dementia with Lewy Bodies.International journal of molecular sciences, , Jul-28, Volume: 24, Issue:15, 2023
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Recent Advances in the Treatment of Genetic Forms of Parkinson's Disease: Hype or Hope?Cells, , 02-27, Volume: 12, Issue:5, 2023
Calcineurin stimulation by Cnb1p overproduction mitigates protein aggregation and α-synuclein toxicity in a yeast model of synucleinopathy.Cell communication and signaling : CCS, , 08-24, Volume: 21, Issue:1, 2023
Novel naturally occurring autoantibodies attenuate α-synuclein pathology in a mouse model of Parkinson's disease.Neuropathology and applied neurobiology, , Volume: 49, Issue:1, 2023
Alpha-Synuclein in Peripheral Tissues as a Possible Marker for Neurological Diseases and Other Medical Conditions.Biomolecules, , 08-18, Volume: 13, Issue:8, 2023
Overexpression of alpha synuclein disrupts APP and Endolysosomal axonal trafficking in a mouse model of synucleinopathy.Neurobiology of disease, , Volume: 178, 2023
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The Bidirectional Interplay of α-Synuclein with Lipids in the Central Nervous System and Its Implications for the Pathogenesis of Parkinson's Disease.International journal of molecular sciences, , Aug-26, Volume: 24, Issue:17, 2023
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Anti-α-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson's disease.Neurobiology of disease, , Volume: 177, 2023
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Dynamic reversibility of α-synuclein serine-129 phosphorylation is impaired in synucleinopathy models.EMBO reports, , Dec-06, Volume: 24, Issue:12, 2023
Dysregulation of astrocytic CaActa neuropathologica, , Volume: 145, Issue:5, 2023
Saturation mutagenesis of α-synuclein reveals monomer fold that modulates aggregation.Science advances, , 10-27, Volume: 9, Issue:43, 2023
Automated algorithm development to assess survival of human neurons using longitudinal single-cell tracking: Application to synucleinopathy.SLAS technology, , Volume: 28, Issue:2, 2023
Double-Edged Effects of Venglustat on Behavior and Pathology in Mice Overexpressing α-Synuclein.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:6, 2023
Peptide-based approaches to directly target alpha-synuclein in Parkinson's disease.Molecular neurodegeneration, , Nov-09, Volume: 18, Issue:1, 2023
Spreading of alpha-synuclein between different cell types.Behavioural brain research, , 01-05, Volume: 436, 2023
On the Track of α-Synuclein in the Body: Skin Biopsies for Diagnosing Synucleinopathies?Neurology, , 04-11, Volume: 100, Issue:15, 2023
Repositioning doxycycline for treating synucleinopathies: Evidence from a pre-clinical mouse model.Parkinsonism & related disorders, , Volume: 106, 2023
Protective mechanisms by glial cell line-derived neurotrophic factor and cerebral dopamine neurotrophic factor against the α-synuclein accumulation in Parkinson's disease.Biochemical Society transactions, , 02-27, Volume: 51, Issue:1, 2023
Kinetic control in amyloid polymorphism: Different agitation and solution conditions promote distinct amyloid polymorphs of alpha-synuclein.Biochimica et biophysica acta. Proteins and proteomics, , Jul-01, Volume: 1871, Issue:4, 2023
In Silico and In Vitro Study towards the Rational Design of 4,4'-Disarylbisthiazoles as a Selective α-Synucleinopathy Biomarker.International journal of molecular sciences, , Nov-17, Volume: 24, Issue:22, 2023
Synucleinopathies Take Their Toll: Are TLRs a Way to Go?Cells, , 04-24, Volume: 12, Issue:9, 2023
α-Synuclein Conformational Strains as Drivers of Phenotypic Heterogeneity in Neurodegenerative Diseases.Journal of molecular biology, , 06-15, Volume: 435, Issue:12, 2023
Loss of cannabinoid receptor 2 promotes α-Synuclein-induced microglial synaptic pruning in nucleus accumbens by modulating the pCREB-c-Fos signaling pathway and complement system.Experimental neurology, , Volume: 359, 2023
Revisiting Alpha-Synuclein Pathways to Inflammation.International journal of molecular sciences, , Apr-12, Volume: 24, Issue:8, 2023
Neuronopathic GBA1L444P Mutation Accelerates Glucosylsphingosine Levels and Formation of Hippocampal Alpha-Synuclein Inclusions.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 01-18, Volume: 43, Issue:3, 2023
CaMovement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:6, 2023
Alpha Synuclein: Neurodegeneration and Inflammation.International journal of molecular sciences, , Mar-21, Volume: 24, Issue:6, 2023
⍺-Synuclein Structural Diversity and the Cellular Environment in ⍺-Synuclein Transmission Models and Humans.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 20, Issue:1, 2023
Urinary tract infections trigger synucleinopathy via the innate immune response.Acta neuropathologica, , Volume: 145, Issue:5, 2023
Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils.Proceedings of the National Academy of Sciences of the United States of America, , 02-14, Volume: 120, Issue:7, 2023
Sequential or Simultaneous Injection of Preformed Fibrils and AAV Overexpression of Alpha-Synuclein Are Equipotent in Producing Relevant Pathology and Behavioral Deficits.Journal of Parkinson's disease, , Volume: 12, Issue:4, 2022
An Update on the Critical Role of α-Synuclein in Parkinson's Disease and Other Synucleinopathies: from Tissue to Cellular and Molecular Levels.Molecular neurobiology, , Volume: 59, Issue:1, 2022
The role of cardiovascular autonomic failure in the differential diagnosis of α-synucleinopathies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 43, Issue:1, 2022
Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies.Cellular and molecular life sciences : CMLS, , Mar-04, Volume: 79, Issue:3, 2022
PTEN-Induced Putative Kinase 1 Dysfunction Accelerates Synucleinopathy.Journal of Parkinson's disease, , Volume: 12, Issue:4, 2022
Neuronal Presentation of Antigen and Its Possible Role in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
Long-standing multiple system atrophy-Parkinsonism with limbic and FTLD-type α-synuclein pathology.Neuropathology and applied neurobiology, , Volume: 48, Issue:3, 2022
Charge detection mass spectrometry on human-amplified fibrils from different synucleinopathies.Chemical communications (Cambridge, England), , Jun-23, Volume: 58, Issue:51, 2022
'Seeding' the idea of early diagnostics in synucleinopathies.Brain : a journal of neurology, , 04-18, Volume: 145, Issue:2, 2022
Treadmill exercise reduces α-synuclein spreading via PPARα.Cell reports, , 07-12, Volume: 40, Issue:2, 2022
Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies.Brain : a journal of neurology, , 04-18, Volume: 145, Issue:2, 2022
Synuclein Analysis in Adult International journal of molecular sciences, , May-27, Volume: 23, Issue:11, 2022
Chalcone Analogue as New Candidate for Selective Detection of α-Synuclein Pathology.ACS chemical neuroscience, , 01-05, Volume: 13, Issue:1, 2022
Low dose DMSO treatment induces oligomerization and accelerates aggregation of α-synuclein.Scientific reports, , 03-08, Volume: 12, Issue:1, 2022
Intermediates of α-synuclein aggregation: Implications in Parkinson's disease pathogenesis.Biophysical chemistry, , Volume: 281, 2022
Bivalent metal ions induce formation of α-synuclein fibril polymorphs with different cytotoxicities.Scientific reports, , 07-13, Volume: 12, Issue:1, 2022
Pathogenic Impact of α-Synuclein Phosphorylation and Its Kinases in α-Synucleinopathies.International journal of molecular sciences, , Jun-01, Volume: 23, Issue:11, 2022
Synuclein-One study: skin biopsy detection of phosphorylated α-synuclein for diagnosis of synucleinopathies.Biomarkers in medicine, , Volume: 16, Issue:7, 2022
Cardiac Alpha-Synuclein Is Present in Alpha-Synucleinopathies.Journal of Parkinson's disease, , Volume: 12, Issue:4, 2022
The roles of connectivity and neuronal phenotype in determining the pattern of α-synuclein pathology in Parkinson's disease.Neurobiology of disease, , 06-15, Volume: 168, 2022
Brain injections of glial cytoplasmic inclusions induce a multiple system atrophy-like pathology.Brain : a journal of neurology, , 04-29, Volume: 145, Issue:3, 2022
Prion-like α-synuclein pathology in the brain of infants with Krabbe disease.Brain : a journal of neurology, , 05-24, Volume: 145, Issue:4, 2022
Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models.Autophagy, , Volume: 18, Issue:5, 2022
Infectious Agents as Potential Drivers of α-Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:3, 2022
Impact of fatty acid-binding proteins and dopamine receptors on α-synucleinopathy.Journal of pharmacological sciences, , Volume: 148, Issue:2, 2022
Impaired Sphingolipid Hydrolase Activities in Dementia with Lewy Bodies and Multiple System Atrophy.Molecular neurobiology, , Volume: 59, Issue:4, 2022
α-Synuclein Radiotracer Development and In Vivo Imaging: Recent Advancements and New Perspectives.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:5, 2022
Parkinson's disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein-induced changes in maturation and immune reactive properties.Proceedings of the National Academy of Sciences of the United States of America, , 03-22, Volume: 119, Issue:12, 2022
Alpha-synuclein Immunization Strategies for Synucleinopathies in Clinical Studies: A Biological Perspective.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 19, Issue:5, 2022
Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy.Proceedings of the National Academy of Sciences of the United States of America, , 02-08, Volume: 119, Issue:6, 2022
Sustained chemogenetic activation of locus coeruleus norepinephrine neurons promotes dopaminergic neuron survival in synucleinopathy.PloS one, , Volume: 17, Issue:3, 2022
Consequences of variability in α-synuclein fibril structure on strain biology.Acta neuropathologica, , Volume: 143, Issue:3, 2022
Alpha and Beta Synucleins: From Pathophysiology to Clinical Application as Biomarkers.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:4, 2022
Alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy.Translational neurodegeneration, , 02-07, Volume: 11, Issue:1, 2022
Senescence and impaired DNA damage responses in alpha-synucleinopathy models.Experimental & molecular medicine, , Volume: 54, Issue:2, 2022
Adenosine A1 receptor ligands bind to α-synuclein: implications for α-synuclein misfolding and α-synucleinopathy in Parkinson's disease.Translational neurodegeneration, , 02-10, Volume: 11, Issue:1, 2022
Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations.Acta neuropathologica, , Volume: 143, Issue:4, 2022
Fluid markers of synapse degeneration in synucleinopathies.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 129, Issue:2, 2022
In vivo imaging of alpha-synuclein with antibody-based PET.Neuropharmacology, , 05-01, Volume: 208, 2022
Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD.Molecular neurodegeneration, , 09-05, Volume: 17, Issue:1, 2022
Extracellular alpha-synuclein: Sensors, receptors, and responses.Neurobiology of disease, , 06-15, Volume: 168, 2022
Leukotriene Signaling as a Target in α-Synucleinopathies.Biomolecules, , 02-23, Volume: 12, Issue:3, 2022
Neurons with Cat's Eyes: A Synthetic Strain of α-Synuclein Fibrils Seeding Neuronal Intranuclear Inclusions.Biomolecules, , 03-11, Volume: 12, Issue:3, 2022
Glutamatergic transmission and receptor expression in the synucleinopathy h-α-synL62 mouse model: Effects of hydromethylthionine.Cellular signalling, , Volume: 97, 2022
Spreading of Aggregated α-Synuclein in Sagittal Organotypic Mouse Brain Slices.Biomolecules, , 01-19, Volume: 12, Issue:2, 2022
Passive Immunization in Alpha-Synuclein Preclinical Animal Models.Biomolecules, , 01-20, Volume: 12, Issue:2, 2022
How Lazy Reading and Semantic Sloppiness May Harm Progress in Synucleinopathy Research.Biomolecules, , 01-28, Volume: 12, Issue:2, 2022
Initiation and progression of α-synuclein pathology in Parkinson's disease.Cellular and molecular life sciences : CMLS, , Mar-26, Volume: 79, Issue:4, 2022
α-synucleinopathy exerts sex-dimorphic effects on the multipurpose DNA repair/redox protein APE1 in mice and humans.Progress in neurobiology, , Volume: 216, 2022
[no title available]International journal of molecular sciences, , Jul-25, Volume: 23, Issue:15, 2022
Synthetic Peucedanocoumarin IV Prevents α-Synuclein Neurotoxicity in an Animal Model of Parkinson's Disease.International journal of molecular sciences, , Aug-03, Volume: 23, Issue:15, 2022
O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies.ACS chemical neuroscience, , 04-20, Volume: 13, Issue:8, 2022
Intracellular Accumulation of α-Synuclein Aggregates Promotes S-Nitrosylation of MAP1A Leading to Decreased NMDAR-Evoked Calcium Influx and Loss of Mature Synaptic Spines.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 12-14, Volume: 42, Issue:50, 2022
Inflammation promotes synucleinopathy propagation.Experimental & molecular medicine, , Volume: 54, Issue:12, 2022
Gastrointestinal Biopsy Obtained During Cancer Screening, a Biological Marker for α-Synucleinopathy?Journal of neuropathology and experimental neurology, , 04-27, Volume: 81, Issue:5, 2022
The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains.The Journal of biological chemistry, , Volume: 298, Issue:5, 2022
Fine Particulate Matter Triggers α-Synuclein Fibrillization and Parkinson-like Neurodegeneration.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:9, 2022
Neuroinflammation and Immune Changes in Prodromal Parkinson's Disease and Other Synucleinopathies.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
α-Synuclein arginylation in the human brain.Translational neurodegeneration, , 04-08, Volume: 11, Issue:1, 2022
Alpha-synucleinopathy reduces NMNAT3 protein levels and neurite formation that can be rescued by targeting the NAD+ pathway.Human molecular genetics, , 08-25, Volume: 31, Issue:17, 2022
Cellular Prion Protein Mediates α-Synuclein Uptake, Localization, and Toxicity In Vitro and In Vivo.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:1, 2022
[Ascendance of Abnormal α-synuclein Fibrils Through the Vagal Nerve in Parkinson's Disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 74, Issue:8, 2022
Synaptic Neurofilaments and GluN1-Neurofilament Light Chain Interaction in Experimental Models of α-Synucleinopathies.Neuro-degenerative diseases, , Volume: 22, Issue:1, 2022
Performance of αSynuclein RT-QuIC in relation to neuropathological staging of Lewy body disease.Acta neuropathologica communications, , 06-22, Volume: 10, Issue:1, 2022
Increased unsaturated lipids underlie lipid peroxidation in synucleinopathy brain.Acta neuropathologica communications, , 11-14, Volume: 10, Issue:1, 2022
High-Contrast Imaging of α-Synuclein Pathologies in Living Patients with Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:10, 2022
Phosphorylated α-Synuclein Deposits in Cutaneous Nerves of Early Parkinsonism.Journal of Parkinson's disease, , Volume: 12, Issue:8, 2022
Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders.Acta neuropathologica communications, , 11-12, Volume: 10, Issue:1, 2022
Exosomes in Alpha-Synucleinopathies: Propagators of Pathology or Potential Candidates for Nanotherapeutics?Biomolecules, , 07-08, Volume: 12, Issue:7, 2022
α-synuclein as an emerging pathophysiological biomarker of Alzheimer's disease.Expert review of molecular diagnostics, , Volume: 22, Issue:4, 2022
α-Synuclein Conformational Plasticity: Physiologic States, Pathologic Strains, and Biotechnological Applications.Biomolecules, , 07-17, Volume: 12, Issue:7, 2022
α-Synuclein Fibrils as Penrose Machines: A Chameleon in the Gear.Biomolecules, , 03-24, Volume: 12, Issue:4, 2022
Gastric Enteric Glial Cells: A New Contributor to the Synucleinopathies in the MPTP-Induced Parkinsonism Mouse.Molecules (Basel, Switzerland), , Nov-01, Volume: 27, Issue:21, 2022
Striatal-Inoculation of α-Synuclein Preformed Fibrils Aggravated the Phenotypes of REM Sleep without Atonia in A53T BAC-SNCA Transgenic Mice.International journal of molecular sciences, , Nov-02, Volume: 23, Issue:21, 2022
Binding Stability of Antibody-α-Synuclein Complexes Predicts the Protective Efficacy of Anti-α-synuclein Antibodies.Molecular neurobiology, , Volume: 59, Issue:7, 2022
The 3D structure of lipidic fibrils of α-synuclein.Nature communications, , 11-10, Volume: 13, Issue:1, 2022
MED13 and glycolysis are conserved modifiers of α-synuclein-associated neurodegeneration.Cell reports, , 12-20, Volume: 41, Issue:12, 2022
Mesoscale connections and gene expression empower whole-brain modeling of α-synuclein spread, aggregation, and decay dynamics.Cell reports, , 11-08, Volume: 41, Issue:6, 2022
Design, Synthesis, and Biological Evaluation of Potent 20S Proteasome Activators for the Potential Treatment of α-Synucleinopathies.Journal of medicinal chemistry, , 05-12, Volume: 65, Issue:9, 2022
[Role of fatty acid-binding protein 7 and novel therapeutic approach in synucleinopathies].Nihon yakurigaku zasshi. Folia pharmacologica Japonica, , Volume: 157, Issue:6, 2022
Unique seeding profiles and prion-like propagation of synucleinopathies are highly dependent on the host in human α-synuclein transgenic mice.Acta neuropathologica, , Volume: 143, Issue:6, 2022
Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial.EBioMedicine, , Volume: 80, 2022
Hytrin loaded polydopamine-serotonin nanohybrid induces IDH2 mediated neuroprotective effect to alleviate Parkinson's disease.Biomaterials advances, , Volume: 133, 2022
Aggregated Alpha-Synuclein Inclusions within the Nucleus Predict Impending Neuronal Cell Death in a Mouse Model of Parkinsonism.International journal of molecular sciences, , Dec-04, Volume: 23, Issue:23, 2022
Diagnostic value of α-synuclein seeding amplification assays in α-synucleinopathies: A systematic review and meta-analysis.Parkinsonism & related disorders, , Volume: 104, 2022
Synucleinopathy in Amyotrophic Lateral Sclerosis: A Potential Avenue for Antisense Therapeutics?International journal of molecular sciences, , Aug-19, Volume: 23, Issue:16, 2022
α-Synuclein fibril-specific nanobody reduces prion-like α-synuclein spreading in mice.Nature communications, , 07-19, Volume: 13, Issue:1, 2022
Pharmacological inhibition of AIMP2 aggregation attenuates α-synuclein aggregation and toxicity in Parkinson's disease.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 156, 2022
Tau accelerates α-synuclein aggregation and spreading in Parkinson's disease.Brain : a journal of neurology, , 10-21, Volume: 145, Issue:10, 2022
Exogenous Tetranectin Alleviates Pre-formed-fibrils-induced Synucleinopathies in SH-SY5Y Cells by Activating the Plasminogen Activation System.Neurochemical research, , Volume: 47, Issue:10, 2022
Sleep-controlling neurons are sensitive and vulnerable to multiple forms of α-synuclein: implications for the early appearance of sleeping disorders in α-synucleinopathies.Cellular and molecular life sciences : CMLS, , Jul-26, Volume: 79, Issue:8, 2022
NOS1AP Interacts with α-Synuclein and Aggregates in Yeast and Mammalian Cells.International journal of molecular sciences, , Aug-14, Volume: 23, Issue:16, 2022
Lysophospholipids-potent candidates for brain food, protects neuronal cells against α-Synuclein aggregation.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 156, 2022
Effects of Lanthionine Ketimine-5-Ethyl Ester on the α-Synucleinopathy Mouse Model.Neurochemical research, , Volume: 47, Issue:8, 2022
Oxidative Stress and Mitochondrial Complex I Dysfunction Correlate with Neurodegeneration in an α-Synucleinopathy Animal Model.International journal of molecular sciences, , Sep-27, Volume: 23, Issue:19, 2022
Neuroprotective Function of Rasagiline and Selegiline, Inhibitors of Type B Monoamine Oxidase, and Role of Monoamine Oxidases in Synucleinopathies.International journal of molecular sciences, , Sep-21, Volume: 23, Issue:19, 2022
Quantum-dot-labeled synuclein seed assay identifies drugs modulating the experimental prion-like transmission.Communications biology, , 06-29, Volume: 5, Issue:1, 2022
Molecular mechanism for the synchronized electrostatic coacervation and co-aggregation of alpha-synuclein and tau.Nature communications, , 08-06, Volume: 13, Issue:1, 2022
ATPase Thorase Deficiency Causes α-Synucleinopathy and Parkinson's Disease-like Behavior.Cells, , 09-26, Volume: 11, Issue:19, 2022
Rapid macropinocytic transfer of α-synuclein to lysosomes.Cell reports, , 07-19, Volume: 40, Issue:3, 2022
Brain atrophy in prodromal synucleinopathy is shaped by structural connectivity and gene expression.Brain : a journal of neurology, , 09-14, Volume: 145, Issue:9, 2022
Involvement of autophagic protein DEF8 in Lewy bodies.Biochemical and biophysical research communications, , 10-01, Volume: 623, 2022
α-Synuclein fibrils explore actin-mediated macropinocytosis for cellular entry into model neuroblastoma neurons.Traffic (Copenhagen, Denmark), , Volume: 23, Issue:7, 2022
Analysis of hemisphere-dependent effects of unilateral intrastriatal injection of α-synuclein pre-formed fibrils on mitochondrial protein levels, dynamics, and function.Acta neuropathologica communications, , 05-23, Volume: 10, Issue:1, 2022
Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models.Nature communications, , 08-22, Volume: 13, Issue:1, 2022
Evidence of seeding capacity of α-synuclein assemblies in infantile Krabbe disease.Brain : a journal of neurology, , 05-24, Volume: 145, Issue:4, 2022
Recent advances in establishing fluid biomarkers for the diagnosis and differentiation of alpha-synucleinopathies - a mini review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 32, Issue:4, 2022
The promise of amplification assays for accurate early detection of α-synucleinopathies: A review.Experimental gerontology, , Volume: 165, 2022
Alpha synuclein processing by MMP-3 - implications for synucleinopathies.Behavioural brain research, , 09-26, Volume: 434, 2022
Quantitative super-resolution imaging of pathological aggregates reveals distinct toxicity profiles in different synucleinopathies.Proceedings of the National Academy of Sciences of the United States of America, , 10-11, Volume: 119, Issue:41, 2022
Extracellular Alpha-Synuclein: Mechanisms for Glial Cell Internalization and Activation.Biomolecules, , 04-30, Volume: 12, Issue:5, 2022
A Combined α-Synuclein/Fibril (SynFib) Model of Parkinson-Like Synucleinopathy Targeting the Nigrostriatal Dopamine System.Journal of Parkinson's disease, , Volume: 12, Issue:8, 2022
A New Zebrafish Model to Measure Neuronal α-Synuclein Clearance In Vivo.Genes, , 05-12, Volume: 13, Issue:5, 2022
Quaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein.Communications biology, , 09-30, Volume: 5, Issue:1, 2022
Retrograde Axonal Autophagy and Endocytic Pathways Are Parallel and Separate in Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 11-09, Volume: 42, Issue:45, 2022
α-synuclein buildup is alleviated via ESCRT-dependent endosomal degradation brought about by p38MAPK inhibition in cells expressing p25α.The Journal of biological chemistry, , Volume: 298, Issue:11, 2022
Modeling Parkinson's disease-related symptoms in alpha-synuclein overexpressing mice.Brain and behavior, , Volume: 12, Issue:7, 2022
Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies.Acta neuropathologica communications, , 06-03, Volume: 10, Issue:1, 2022
α-Synuclein Seed Amplification Assays for Diagnosing Synucleinopathies: The Way Forward.Neurology, , 08-02, Volume: 99, Issue:5, 2022
Transcellular propagation of fibrillar α-synuclein from enteroendocrine to neuronal cells requires cell-to-cell contact and is Rab35-dependent.Scientific reports, , 03-09, Volume: 12, Issue:1, 2022
Idiopathic rapid eye movement sleep behavior disorder in Japan: An observational study.Parkinsonism & related disorders, , Volume: 103, 2022
Production of Recombinant Alpha-Synuclein: Still No Standardized Protocol in Sight.Biomolecules, , 02-18, Volume: 12, Issue:2, 2022
Dual Effects: Intrastriatal Injection of α-syn N103/tau N368 Preformed Fibrils Promotes Endogenous α-synuclein Aggregates in the Proximal Colon.Journal of Parkinson's disease, , Volume: 12, Issue:7, 2022
Alpha-Synuclein RT-QuIC in Idiopathic Normal Pressure Hydrocephalus.Annals of neurology, , Volume: 92, Issue:6, 2022
Distinct Aβ pathology in the olfactory bulb and olfactory deficits in a mouse model of Aβ and α-syn co-pathology.Brain pathology (Zurich, Switzerland), , Volume: 32, Issue:3, 2022
Early Signs of Molecular Defects in iPSC-Derived Neural Stems Cells from Patients with Familial Parkinson's Disease.Biomolecules, , 06-23, Volume: 12, Issue:7, 2022
Brain regions susceptible to alpha-synuclein spreading.Molecular psychiatry, , Volume: 27, Issue:1, 2022
ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease.Neurobiology of disease, , Volume: 161, 2021
Inhibition of copper transporter 1 prevents α-synuclein pathology and alleviates nigrostriatal degeneration in AAV-based mouse model of Parkinson's disease.Redox biology, , Volume: 38, 2021
Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo.Neurobiology of disease, , Volume: 151, 2021
Synaptic vesicle-inspired nanoparticles with spatiotemporally controlled release ability as a "nanoguard" for synergistic treatment of synucleinopathies.Materials horizons, , 04-01, Volume: 8, Issue:4, 2021
The Small Molecule Alpha-Synuclein Aggregator, FN075, Enhances Alpha-Synuclein Pathology in Subclinical AAV Rat Models.Biomolecules, , 11-12, Volume: 11, Issue:11, 2021
Autophagy in α-Synucleinopathies-An Overstrained System.Cells, , 11-12, Volume: 10, Issue:11, 2021
The Parkinson's disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release.Proceedings of the National Academy of Sciences of the United States of America, , 01-05, Volume: 118, Issue:1, 2021
Slow-wave sleep affects synucleinopathy and regulates proteostatic processes in mouse models of Parkinson's disease.Science translational medicine, , 12-08, Volume: 13, Issue:623, 2021
Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential.Acta neuropathologica, , Volume: 142, Issue:1, 2021
RT-QuIC for detection of prodromal α-synucleinopathies.The Lancet. Neurology, , Volume: 20, Issue:3, 2021
Truncation-Driven Lateral Association of α-Synuclein Hinders Amyloid Clearance by the Hsp70-Based Disaggregase.International journal of molecular sciences, , Nov-30, Volume: 22, Issue:23, 2021
Toward a Disease-Modifying Therapy of Alpha-Synucleinopathies: New Molecules and New Approaches Came into the Limelight.Molecules (Basel, Switzerland), , Dec-03, Volume: 26, Issue:23, 2021
Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain.Acta neuropathologica communications, , 02-25, Volume: 9, Issue:1, 2021
Neuropathology and molecular diagnosis of Synucleinopathies.Molecular neurodegeneration, , 12-18, Volume: 16, Issue:1, 2021
Suppression of α-synuclein propagation after intrastriatal injection in FABP3 null mice.Brain research, , 06-01, Volume: 1760, 2021
Effect of Docosahexaenoic Acid (DHA) at the Enteric Level in a Synucleinopathy Mouse Model.Nutrients, , Nov-24, Volume: 13, Issue:12, 2021
Reduction of Lewy Body Pathology by Oral Cinnamon.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 16, Issue:3, 2021
From Posttranslational Modifications to Disease Phenotype: A Substrate Selection Hypothesis in Neurodegenerative Diseases.International journal of molecular sciences, , Jan-18, Volume: 22, Issue:2, 2021
Lipotoxicity Downstream of α-Synuclein Imbalance: A Relevant Pathomechanism in Synucleinopathies?Biomolecules, , 12-28, Volume: 12, Issue:1, 2021
Peripheral synucleinopathy in Parkinson disease with LRRK2 G2385R variants.Annals of clinical and translational neurology, , Volume: 8, Issue:3, 2021
Intracranial administration of alpha-synuclein fibrils in A30P-synuclein transgenic mice causes robust synucleinopathy and microglial induction.Neurobiology of aging, , Volume: 106, 2021
In Vivo Diagnosis of Synucleinopathies: A Comparative Study of Skin Biopsy and RT-QuIC.Neurology, , 05-18, Volume: 96, Issue:20, 2021
Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies.Cells, , 02-12, Volume: 10, Issue:2, 2021
Benzo(a)pyrene exposure in utero exacerbates Parkinson's Disease (PD)-like α-synucleinopathy in A53T human alpha-synuclein transgenic mice.Toxicology and applied pharmacology, , 09-15, Volume: 427, 2021
REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 04-21, Volume: 41, Issue:16, 2021
Variable expression of mitochondrial complex IV in the course of nigral intracellular accumulation of α-synuclein.Parkinsonism & related disorders, , Volume: 90, 2021
Differential seeding and propagating efficiency of α-synuclein strains generated in different conditions.Translational neurodegeneration, , 06-21, Volume: 10, Issue:1, 2021
The α-Synuclein Origin and Connectome Model (SOC Model) of Parkinson's Disease: Explaining Motor Asymmetry, Non-Motor Phenotypes, and Cognitive Decline.Journal of Parkinson's disease, , Volume: 11, Issue:2, 2021
Vesicle trafficking and lipid metabolism in synucleinopathy.Acta neuropathologica, , Volume: 141, Issue:4, 2021
α-Synuclein Strains: Does Amyloid Conformation Explain the Heterogeneity of Synucleinopathies?Biomolecules, , 06-23, Volume: 11, Issue:7, 2021
Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies.Acta neuropathologica communications, , 08-28, Volume: 9, Issue:1, 2021
Brain iron enrichment attenuates α-synuclein spreading after injection of preformed fibrils.Journal of neurochemistry, , Volume: 159, Issue:3, 2021
Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids.Acta neuropathologica, , Volume: 142, Issue:5, 2021
Gene Therapy to Modulate Alpha-Synuclein in Synucleinopathies.Journal of Parkinson's disease, , Volume: 11, Issue:s2, 2021
The Human Hippocampus in Parkinson's Disease: An Integrative Stereological and Proteomic Study.Journal of Parkinson's disease, , Volume: 11, Issue:3, 2021
Neurons and Glia Interplay in α-Synucleinopathies.International journal of molecular sciences, , May-08, Volume: 22, Issue:9, 2021
Evidence of distinct α-synuclein strains underlying disease heterogeneity.Acta neuropathologica, , Volume: 142, Issue:1, 2021
Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates α-synuclein Pathology in a Mouse Model of α-Synuclein Propagation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 18, Issue:2, 2021
Preface to an editorial controversy on α-synuclein: How good are cellular models?: This is a Preface for an Editorial controversy between Hilal A. Lashuel "Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complemenJournal of neurochemistry, , Volume: 157, Issue:4, 2021
Deficiency of the serine peptidase Kallikrein 6 does not affect the levels and the pathological accumulation of a-synuclein in mouse brain.Journal of neurochemistry, , Volume: 157, Issue:6, 2021
Neuroprotection of Exendin-4 by Enhanced Autophagy in a Parkinsonian Rat Model of α-Synucleinopathy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 18, Issue:2, 2021
Effects of Alpha-Synuclein Targeted Antisense Oligonucleotides on Lewy Body-Like Pathology and Behavioral Disturbances Induced by Injections of Pre-Formed Fibrils in the Mouse Motor Cortex.Journal of Parkinson's disease, , Volume: 11, Issue:3, 2021
Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson's disease.Acta neuropathologica communications, , 03-20, Volume: 9, Issue:1, 2021
Vagus Nerve and Stomach Synucleinopathy in Parkinson's Disease, Incidental Lewy Body Disease, and Normal Elderly Subjects: Evidence Against the "Body-First" Hypothesis.Journal of Parkinson's disease, , Volume: 11, Issue:4, 2021
Common Marmoset Model of α-Synuclein Propagation.Methods in molecular biology (Clifton, N.J.), , Volume: 2322, 2021
Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder.The Lancet. Neurology, , Volume: 20, Issue:8, 2021
Monitoring of a progressive functional dopaminergic deficit in the A53T-AAV synuclein rats by combining 6-[Neurobiology of aging, , Volume: 107, 2021
Preformed fibrils generated from mouse alpha-synuclein produce more inclusion pathology in rats than fibrils generated from rat alpha-synuclein.Parkinsonism & related disorders, , Volume: 89, 2021
[The novel mechanism of α-synuclein propagation in synucleinopathy].Nihon yakurigaku zasshi. Folia pharmacologica Japonica, , Volume: 156, Issue:4, 2021
Progression of phosphorylated α-synuclein in Macaca fuscata.Brain pathology (Zurich, Switzerland), , Volume: 31, Issue:5, 2021
Equine pituitary pars intermedia dysfunction: a spontaneous model of synucleinopathy.Scientific reports, , 08-06, Volume: 11, Issue:1, 2021
Pure autonomic failure and the differential diagnosis of autonomic peripheral neuropathies.Current opinion in neurology, , 10-01, Volume: 34, Issue:5, 2021
Beyond Just Connectivity - Neuronal Activity Drives α-Synuclein Pathology.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:7, 2021
In Vivo Detection of Underlying Synucleinopathies: Are We There Yet?Neurology, , 05-18, Volume: 96, Issue:20, 2021
Identifying the best biomarkers for α-synucleinopathies.The Lancet. Neurology, , Volume: 20, Issue:8, 2021
α-Synuclein Seeding Assay Using RT-QuIC.Methods in molecular biology (Clifton, N.J.), , Volume: 2322, 2021
Fatal attraction - The role of hypoxia when alpha-synuclein gets intimate with mitochondria.Neurobiology of aging, , Volume: 107, 2021
A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies.Acta neuropathologica, , Volume: 142, Issue:3, 2021
Preclinical Detection of Alpha-Synuclein Seeding Activity in the Colon of a Transgenic Mouse Model of Synucleinopathy by RT-QuIC.Viruses, , 04-26, Volume: 13, Issue:5, 2021
Inflammation in Experimental Models of α-Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:1, 2021
Phytochemicals as Regulators of Genes Involved in Synucleinopathies.Biomolecules, , 04-22, Volume: 11, Issue:5, 2021
Alpha-synuclein pathology, microgliosis, and parvalbumin neuron loss in the amygdala associated with enhanced fear in the Thy1-aSyn model of Parkinson's disease.Neurobiology of disease, , Volume: 158, 2021
Perampanel Inhibits α-Synuclein Transmission in Parkinson's Disease Models.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:7, 2021
Alpha-synuclein pathology of olfactory bulbs/peduncles in the Vantaa85+ cohort exhibit two divergent patterns: a population-based study.Acta neuropathologica, , Volume: 142, Issue:4, 2021
T Cells Limit Accumulation of Aggregate Pathology Following Intrastriatal Injection of α-Synuclein Fibrils.Journal of Parkinson's disease, , Volume: 11, Issue:2, 2021
Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures.Molecular neurodegeneration, , 08-11, Volume: 16, Issue:1, 2021
MicroRNA-7 Protects Against Neurodegeneration Induced by α-Synuclein Preformed Fibrils in the Mouse Brain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 18, Issue:4, 2021
LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies.EMBO molecular medicine, , 09-07, Volume: 13, Issue:9, 2021
[Neuroprotective treatment of idiopathic, genetic and atypical Parkinson's disease with alpha-synuclein-Pathology].Der Nervenarzt, , Volume: 92, Issue:12, 2021
Crucial Role of FABP3 in αSyn-Induced Reduction of Septal GABAergic Neurons and Cognitive Decline in Mice.International journal of molecular sciences, , Jan-01, Volume: 22, Issue:1, 2021
Astrocyte dysfunction in Parkinson's disease: from the perspectives of transmitted α-synuclein and genetic modulation.Translational neurodegeneration, , 10-18, Volume: 10, Issue:1, 2021
Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption.Nature communications, , 10-08, Volume: 12, Issue:1, 2021
Analysis of Brain Protein Stability Changes in Mouse Models of Normal Aging and α-Synucleinopathy Reveals Age- and Disease-Related Differences.Journal of proteome research, , 11-05, Volume: 20, Issue:11, 2021
Cortical alpha-synuclein preformed fibrils do not affect interval timing in mice.Neuroscience letters, , 11-20, Volume: 765, 2021
Grafts Derived from an α-Synuclein Triplication Patient Mediate Functional Recovery but Develop Disease-Associated Pathology in the 6-OHDA Model of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 11, Issue:2, 2021
Alpha-Synuclein and Lipids: The Elephant in the Room?Cells, , 09-17, Volume: 10, Issue:9, 2021
Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Familial Parkinson's Disease Patients Display α-Synuclein Pathology and Abnormal Mitochondrial Morphology.Cells, , 09-13, Volume: 10, Issue:9, 2021
A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy.Neurobiology of disease, , Volume: 159, 2021
Hypomethylation of SNCA in Idiopathic REM Sleep Behavior Disorder Associated With Phenoconversion.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:4, 2021
CD8 T cell nigral infiltration precedes synucleinopathy in early stages of Parkinson's disease.Brain : a journal of neurology, , 12-01, Volume: 143, Issue:12, 2020
Phenotypic Heterogeneity in α-Synucleinopathies: Straining the Difference.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:4, 2020
Novel antibodies detect additional α-synuclein pathology in synucleinopathies: potential development for immunotherapy.Alzheimer's research & therapy, , 11-30, Volume: 12, Issue:1, 2020
LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies.Science translational medicine, , 10-14, Volume: 12, Issue:565, 2020
Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions.Acta neuropathologica communications, , 08-12, Volume: 8, Issue:1, 2020
Astrocytes Protect Human Dopaminergic Neurons from α-Synuclein Accumulation and Propagation.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 11-04, Volume: 40, Issue:45, 2020
Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy.Acta neuropathologica communications, , 08-28, Volume: 8, Issue:1, 2020
Autonomic ganglionic injection of α-synuclein fibrils as a model of pure autonomic failure α-synucleinopathy.Nature communications, , 02-18, Volume: 11, Issue:1, 2020
Deciphering the robustness of pyrazolo-pyridine carboxylate core structure-based compounds for inhibiting α-synuclein in transgenic C. elegans model of Synucleinopathy.Bioorganic & medicinal chemistry, , 09-01, Volume: 28, Issue:17, 2020
Back and to the Future: From Neurotoxin-Induced to Human Parkinson's Disease Models.Current protocols in neuroscience, , Volume: 91, Issue:1, 2020
Blood Flow as a Route for Bidirectional Propagation of Synucleinopathy in Parkinson's Disease?Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:10, 2020
Modeling α-Synucleinopathy in Organotypic Brain Slice Culture with Preformed α-Synuclein Amyloid Fibrils.Journal of Parkinson's disease, , Volume: 10, Issue:4, 2020
Somatic mutations in neurodegeneration: An update.Neurobiology of disease, , Volume: 144, 2020
A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice.eLife, , 02-11, Volume: 9, 2020
GBA1 mutations: Prospects for exosomal biomarkers in α-synuclein pathologies.Molecular genetics and metabolism, , Volume: 129, Issue:2, 2020
RT-QuIC-based detection of alpha-synuclein seeding activity in brains of dementia with Lewy Body patients and of a transgenic mouse model of synucleinopathy.Prion, , Volume: 14, Issue:1, 2020
Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies.Biochimica et biophysica acta. Proteins and proteomics, , Volume: 1868, Issue:1, 2020
α-Synuclein Induces Progressive Changes in Brain Microstructure and Sensory-Evoked Brain Function That Precedes Locomotor Decline.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 08-19, Volume: 40, Issue:34, 2020
[REM Sleep Behavior Disorder and α-synucleinopathy].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:2, 2020
Alpha-synuclein/synapsin III pathological interplay boosts the motor response to methylphenidate.Neurobiology of disease, , Volume: 138, 2020
APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid.Science translational medicine, , 02-05, Volume: 12, Issue:529, 2020
Transfer of pathological α-synuclein from neurons to astrocytes via exosomes causes inflammatory responses after METH exposure.Toxicology letters, , Oct-01, Volume: 331, 2020
α-Synuclein strains target distinct brain regions and cell types.Nature neuroscience, , Volume: 23, Issue:1, 2020
Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD.Proceedings of the National Academy of Sciences of the United States of America, , 06-30, Volume: 117, Issue:26, 2020
Assessment of the Retina of Plp-α-Syn Mice as a Model for Studying Synuclein-Dependent Diseases.Investigative ophthalmology & visual science, , 06-03, Volume: 61, Issue:6, 2020
Reduced cerebral blood flow in an Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 40, Issue:12, 2020
Infections or Sepsis Preceding Clinically Diagnosed α-Synucleinopathies: A Case-Control Study.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:9, 2020
Preserved proteinase K-resistant core after amplification of alpha-synuclein aggregates: Implication to disease-related structural study.Biochemical and biophysical research communications, , 02-12, Volume: 522, Issue:3, 2020
Propagated α-synucleinopathy recapitulates REM sleep behaviour disorder followed by parkinsonian phenotypes in mice.Brain : a journal of neurology, , 12-05, Volume: 143, Issue:11, 2020
Traumatic brain injury and α-synuclein: Proceed with caution.Neurology, , 02-25, Volume: 94, Issue:8, 2020
Anti-aggregation Effects of Phenolic Compounds on α-synuclein.Molecules (Basel, Switzerland), , May-24, Volume: 25, Issue:10, 2020
Effect of the micro-environment on α-synuclein conversion and implication in seeded conversion assays.Translational neurodegeneration, , Volume: 9, 2020
Astrocyte glutamate transporters are increased in an early sporadic model of synucleinopathy.Neurochemistry international, , Volume: 138, 2020
Protein Quality Control Pathways at the Crossroad of Synucleinopathies.Journal of Parkinson's disease, , Volume: 10, Issue:2, 2020
Protein trapping leads to altered synaptic proteostasis in synucleinopathies.The FEBS journal, , Volume: 287, Issue:24, 2020
Glucocerebrosidase deficiency promotes release of α-synuclein fibrils from cultured neurons.Human molecular genetics, , 06-27, Volume: 29, Issue:10, 2020
X1INH, an improved next-generation affinity-optimized hydrazonic ligand, attenuates abnormal copper(I)/copper(II)-α-Syn interactions and affects protein aggregation in a cellular model of synucleinopathy.Dalton transactions (Cambridge, England : 2003), , Nov-25, Volume: 49, Issue:45, 2020
Using carrot cells as biofactories and oral delivery vehicles of LTB-Syn: A low-cost vaccine candidate against synucleinopathies.Journal of biotechnology, , Feb-10, Volume: 309, 2020
Perturbation of in vivo Neural Activity Following α-Synuclein Seeding in the Olfactory Bulb.Journal of Parkinson's disease, , Volume: 10, Issue:4, 2020
Carboxy-terminal truncation and phosphorylation of α-synuclein elongates survival in a prion-like seeding mouse model of synucleinopathy.Neuroscience letters, , 07-27, Volume: 732, 2020
Fine-Mapping of SNCA in Rapid Eye Movement Sleep Behavior Disorder and Overt Synucleinopathies.Annals of neurology, , Volume: 87, Issue:4, 2020
Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies.Acta neuropathologica, , Volume: 140, Issue:1, 2020
Do Lewy bodies contain alpha-synuclein fibrils? and Does it matter? A brief history and critical analysis of recent reports.Neurobiology of disease, , Volume: 141, 2020
Analysis of Protein Conformational Strains-A Key for New Diagnostic Methods of Human Diseases.International journal of molecular sciences, , Apr-17, Volume: 21, Issue:8, 2020
Neuronal activity modulates alpha-synuclein aggregation and spreading in organotypic brain slice cultures and in vivo.Acta neuropathologica, , Volume: 140, Issue:6, 2020
α-Synucleinopathy associated c-Abl activation causes p53-dependent autophagy impairment.Molecular neurodegeneration, , 04-16, Volume: 15, Issue:1, 2020
Nilotinib Fails to Prevent Synucleinopathy and Cell Loss in a Mouse Model of Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:7, 2020
Synucleinopathies: Where we are and where we need to go.Journal of neurochemistry, , Volume: 153, Issue:4, 2020
Mechanisms of alpha-synuclein toxicity: An update and outlook.Progress in brain research, , Volume: 252, 2020
Freezing and piercing of in vitro asymmetric plasma membrane by α-synuclein.Communications biology, , 03-31, Volume: 3, Issue:1, 2020
α-Synuclein filaments from transgenic mouse and human synucleinopathy-containing brains are major seed-competent species.The Journal of biological chemistry, , 05-08, Volume: 295, Issue:19, 2020
NK cells clear α-synuclein and the depletion of NK cells exacerbates synuclein pathology in a mouse model of α-synucleinopathy.Proceedings of the National Academy of Sciences of the United States of America, , 01-21, Volume: 117, Issue:3, 2020
Spinal cord involvement in Lewy body-related α-synucleinopathies.The journal of spinal cord medicine, , Volume: 43, Issue:6, 2020
Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult.Neuron, , 03-04, Volume: 105, Issue:5, 2020
Novel self-replicating α-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in neurons.Science advances, , Volume: 6, Issue:40, 2020
Generation of monoclonal antibodies against phosphorylated α-Synuclein at serine 129: Research tools for synucleinopathies.Neuroscience letters, , 04-23, Volume: 725, 2020
Disruption of cellular proteostasis by H1N1 influenza A virus causes α-synuclein aggregation.Proceedings of the National Academy of Sciences of the United States of America, , 03-24, Volume: 117, Issue:12, 2020
Initiation of Parkinson's disease from gut to brain by δ-secretase.Cell research, , Volume: 30, Issue:1, 2020
Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts.BMC complementary medicine and therapies, , Mar-06, Volume: 20, Issue:1, 2020
APOENature reviews. Neurology, , Volume: 16, Issue:4, 2020
Associations Between APOE Variants, Tau and α-Synuclein.Advances in experimental medicine and biology, , Volume: 1184, 2019
Toll-like receptors and their therapeutic potential in Parkinson's disease and α-synucleinopathies.Brain, behavior, and immunity, , Volume: 81, 2019
Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies.Cell reports, , 07-02, Volume: 28, Issue:1, 2019
Comparative analyses of the in vivo induction and transmission of α-synuclein pathology in transgenic mice by MSA brain lysate and recombinant α-synuclein fibrils.Acta neuropathologica communications, , 05-20, Volume: 7, Issue:1, 2019
Understanding the pathogenesis of multiple system atrophy: state of the art and future perspectives.Acta neuropathologica communications, , 07-12, Volume: 7, Issue:1, 2019
ARSA variants in α-synucleinopathies.Brain : a journal of neurology, , 12-01, Volume: 142, Issue:12, 2019
Loss of One Engrailed1 Allele Enhances Induced α-Synucleinopathy.Journal of Parkinson's disease, , Volume: 9, Issue:2, 2019
A small molecule autophagy inducer exerts cytoprotection against α-synuclein toxicity.European journal of pharmacology, , Nov-05, Volume: 862, 2019
Cellular models of alpha-synuclein toxicity and aggregation.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Slow Progressive Accumulation of Oligodendroglial Alpha-Synuclein (α-Syn) Pathology in Synthetic α-Syn Fibril-Induced Mouse Models of Synucleinopathy.Journal of neuropathology and experimental neurology, , 10-01, Volume: 78, Issue:10, 2019
Heterogeneity in gut microbiota drive polyphenol metabolism that influences α-synuclein misfolding and toxicity.The Journal of nutritional biochemistry, , Volume: 64, 2019
The center of olfactory bulb-seeded α-synucleinopathy is the limbic system and the ensuing pathology is higher in male than in female mice.Brain pathology (Zurich, Switzerland), , Volume: 29, Issue:6, 2019
Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts.Nature communications, , 12-04, Volume: 10, Issue:1, 2019
Hsp110 mitigates α-synuclein pathology in vivo.Proceedings of the National Academy of Sciences of the United States of America, , 11-26, Volume: 116, Issue:48, 2019
α-synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Integrins-A missing link in synuclein's pathogenic mechanism.Journal of neuroscience research, , Volume: 97, Issue:5, 2019
Prion-like propagation of α-synuclein in neurodegenerative diseases.Progress in molecular biology and translational science, , Volume: 168, 2019
Alpha-synuclein is highly prone to distribution in the hippocampus and midbrain in tree shrews, and its fibrils seed Lewy body-like pathology in primary neurons.Experimental gerontology, , Volume: 116, 2019
Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates.Acta neuropathologica communications, , 12-19, Volume: 7, Issue:1, 2019
[Animal models of synucleinopathies: prion-like propagation of alpha-synuclein in wild-type animals].Nihon yakurigaku zasshi. Folia pharmacologica Japonica, , Volume: 154, Issue:6, 2019
Can infections trigger alpha-synucleinopathies?Progress in molecular biology and translational science, , Volume: 168, 2019
Moving forward the in vivo diagnosis of the synucleinopathies.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 29, Issue:6, 2019
Intrastriatal alpha-synuclein fibrils in monkeys: spreading, imaging and neuropathological changes.Brain : a journal of neurology, , 11-01, Volume: 142, Issue:11, 2019
Ultrasensitive Detection of Aggregated α-Synuclein in Glial Cells, Human Cerebrospinal Fluid, and Brain Tissue Using the RT-QuIC Assay: New High-Throughput Neuroimmune Biomarker Assay for Parkinsonian Disorders.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 14, Issue:3, 2019
Glucocerebrosidase mutations and synucleinopathies: Toward a model of precision medicine.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:1, 2019
Polysomnographic data in Dementia with Lewy Bodies: correlation with clinical symptoms and comparison with other α-synucleinopathies.Sleep medicine, , Volume: 55, 2019
Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology.Neurobiology of aging, , Volume: 83, 2019
Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models.Acta neuropathologica, , Volume: 138, Issue:3, 2019
Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery.Cells, , 06-09, Volume: 8, Issue:6, 2019
Oral and intravenous transmission of α-synuclein fibrils to mice.Acta neuropathologica, , Volume: 138, Issue:4, 2019
From Yeast to Humans: Leveraging New Approaches in Yeast to Accelerate Discovery of Therapeutic Targets for Synucleinopathies.Methods in molecular biology (Clifton, N.J.), , Volume: 2049, 2019
Oligodendroglial α-synucleinopathy-driven neuroinflammation in multiple system atrophy.Brain pathology (Zurich, Switzerland), , Volume: 29, Issue:3, 2019
Transmission of α-synuclein seeds in neurodegenerative disease: recent developments.Laboratory investigation; a journal of technical methods and pathology, , Volume: 99, Issue:7, 2019
Antibodies against alpha-synuclein: tools and therapies.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
"Minimal change" multiple system atrophy with limbic-predominant α-synuclein pathology.Acta neuropathologica, , Volume: 137, Issue:1, 2019
In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategies.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Precision Medicine in Rapid Eye Movement Sleep Behavior Disorder.Sleep medicine clinics, , Volume: 14, Issue:3, 2019
Simultaneous tonic and phasic REM sleep without atonia best predicts early phenoconversion to neurodegenerative disease in idiopathic REM sleep behavior disorder.Sleep, , 09-06, Volume: 42, Issue:9, 2019
Neuronal inclusions and α-Synucleinopathy in a patient with 5p deletion syndrome.Journal of the neurological sciences, , Aug-15, Volume: 403, 2019
Seeding variability of different alpha synuclein strains in synucleinopathies.Annals of neurology, , Volume: 85, Issue:5, 2019
Genetically engineered stem cell-derived neurons can be rendered resistant to alpha-synuclein aggregate pathology.The European journal of neuroscience, , Volume: 49, Issue:3, 2019
Chronic Mild Gut Inflammation Accelerates Brain Neuropathology and Motor Dysfunction in α-Synuclein Mutant Mice.Neuromolecular medicine, , Volume: 21, Issue:3, 2019
[no title available]Neurology, , 07-16, Volume: 93, Issue:3, 2019
Plant poisoning leads to alpha-synucleinopathy and neuromelanopathy in kangaroos.Scientific reports, , 11-13, Volume: 9, Issue:1, 2019
Clinical and neuropathological differences between Parkinson's disease, Parkinson's disease dementia and dementia with Lewy bodies - current issues and future directions.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
CSF Biomarkers for Early Diagnosis of Synucleinopathies: Focus on Idiopathic RBD.Current neurology and neuroscience reports, , 01-14, Volume: 19, Issue:2, 2019
Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo.Journal of visualized experiments : JoVE, , 06-02, Issue:148, 2019
Alpha-synuclein at the nexus of genes and environment: the impact of environmental enrichment and stress on brain health and disease.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
α-Synuclein pathology in Parkinson's disease and related α-synucleinopathies.Neuroscience letters, , 09-14, Volume: 709, 2019
Classification of GBA Variants and Their Effects in Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:10, 2019
Connectivity and vulnerability determine α-synuclein spread.Nature reviews. Neurology, , Volume: 15, Issue:10, 2019
Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies.Cells, , 10-10, Volume: 8, Issue:10, 2019
Engineering synucleinopathy-resistant human dopaminergic neurons by CRISPR-mediated deletion of the SNCA gene.The European journal of neuroscience, , Volume: 49, Issue:4, 2019
α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb.Acta neuropathologica communications, , 12-30, Volume: 7, Issue:1, 2019
Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons.Human molecular genetics, , 06-15, Volume: 28, Issue:12, 2019
Deployment of Label-Free Quantitative Olfactory Proteomics to Detect Cerebrospinal Fluid Biomarker Candidates in Synucleinopathies.Methods in molecular biology (Clifton, N.J.), , Volume: 2044, 2019
Synuclein Meeting 2019: where we are and where we need to go.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Early defects in translation elongation factor 1α levels at excitatory synapses in α-synucleinopathy.Acta neuropathologica, , Volume: 138, Issue:6, 2019
Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils.Neurobiology of disease, , Volume: 130, 2019
Development of FABP3 ligands that inhibit arachidonic acid-induced α-synuclein oligomerization.Brain research, , 03-15, Volume: 1707, 2019
Pronounced α-Synuclein Pathology in a Seeding-Based Mouse Model Is Not Sufficient to Induce Mitochondrial Respiration Deficits in the Striatum and Amygdala.eNeuro, , Volume: 7, Issue:4
DNAJB6b is Downregulated in Synucleinopathies.Journal of Parkinson's disease, , Volume: 11, Issue:4
The differential solvent exposure of N-terminal residues provides "fingerprints" of alpha-synuclein fibrillar polymorphs.The Journal of biological chemistry, , Volume: 296
Detection of Dermal Alpha-Synuclein Deposits as a Biomarker for Parkinson's Disease.Journal of Parkinson's disease, , Volume: 11, Issue:3
Nonclinical safety evaluation, pharmacokinetics, and target engagement of Lu AF82422, a monoclonal IgG1 antibody against alpha-synuclein in development for treatment of synucleinopathies.mAbs, , Volume: 13, Issue:1
SARS-COV-2 infection and Parkinson's disease: Possible links and perspectives.Journal of neuroscience research, , Volume: 101, Issue:6, 2023
SARS-CoV-2 N-protein induces the formation of composite α-synuclein/N-protein fibrils that transform into a strain of α-synuclein fibrils.Nanoscale, , Nov-23, Volume: 15, Issue:45, 2023
Are patients with Parkinson's disease at a lower risk of catching the common cold? Propensity score matching.Parkinsonism & related disorders, , Volume: 106, 2023
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein.Molecular psychiatry, , Volume: 28, Issue:7, 2023
Dopamine Transmission Imbalance in Neuroinflammation: Perspectives on Long-Term COVID-19.International journal of molecular sciences, , Mar-15, Volume: 24, Issue:6, 2023
Viral-like TLR3 induction of cytokine networks and α-synuclein are reduced by complement C3 blockade in mouse brain.Scientific reports, , 09-13, Volume: 13, Issue:1, 2023
SARS-CoV-2 Proteins Interact with Alpha Synuclein and Induce Lewy Body-like Pathology In Vitro.International journal of molecular sciences, , Mar-21, Volume: 23, Issue:6, 2022
A case series of cutaneous phosphorylated α-synuclein in Long-COVID POTS.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 32, Issue:3, 2022
Microgliosis and neuronal proteinopathy in brain persist beyond viral clearance in SARS-CoV-2 hamster model.EBioMedicine, , Volume: 79, 2022
Interactions between SARS-CoV-2 N-Protein and α-Synuclein Accelerate Amyloid Formation.ACS chemical neuroscience, , 01-05, Volume: 13, Issue:1, 2022
Effect of an Amyloidogenic SARS-COV-2 Protein Fragment on α-Synuclein Monomers and Fibrils.The journal of physical chemistry. B, , 05-26, Volume: 126, Issue:20, 2022
Smell deficits in COVID-19 and possible links with Parkinson's disease.International review of neurobiology, , Volume: 165, 2022
Modulation of the Conformational Space of SARS-CoV-2 RNA Quadruplex RG-1 by Cellular Components and the Amyloidogenic Peptides α-Synuclein and hIAPP.Chemistry (Weinheim an der Bergstrasse, Germany), , Feb-16, Volume: 28, Issue:9, 2022
Exploring the Paradox of COVID-19 in Neurological Complications with Emphasis on Parkinson's and Alzheimer's Disease.Oxidative medicine and cellular longevity, , Volume: 2022, 2022
Moderate Binding between Two SARS-CoV-2 Protein Segments and α-Synuclein Alters Its Toxic Oligomerization Propensity Differently.The journal of physical chemistry letters, , Nov-17, Volume: 13, Issue:45, 2022
Post-COVID-19 Parkinsonism and Parkinson's Disease Pathogenesis: The Exosomal Cargo Hypothesis.International journal of molecular sciences, , Aug-28, Volume: 23, Issue:17, 2022
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In Pancreatic Adenocarcinoma Alpha-Synuclein Increases and Marks Peri-Neural Infiltration.International journal of molecular sciences, , Mar-29, Volume: 23, Issue:7, 2022
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Folium Hibisci Mutabilis extract, a potent autophagy enhancer, exhibits neuroprotective properties in multiple models of neurodegenerative diseases.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 109, 2023
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Are patients with Parkinson's disease at a lower risk of catching the common cold? Propensity score matching.Parkinsonism & related disorders, , Volume: 106, 2023
The Mediating Role of Inflammation in the Relationship Between α-Synuclein and Cognitive Functioning.The journals of gerontology. Series A, Biological sciences and medical sciences, , 02-24, Volume: 78, Issue:2, 2023
Extracellular vesicle biomarkers for cognitive impairment in Parkinson's disease.Brain : a journal of neurology, , 01-05, Volume: 146, Issue:1, 2023
Phosphorylated α-synuclein in skin Schwann cells: a new biomarker for multiple system atrophy.Brain : a journal of neurology, , 03-01, Volume: 146, Issue:3, 2023
Tailoring a Nanochaperone to Regulate α-Synuclein Assembly.Angewandte Chemie (International ed. in English), , 05-02, Volume: 61, Issue:19, 2022
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Molecular Insights into the Effect of Metals on Amyloid Aggregation.Methods in molecular biology (Clifton, N.J.), , Volume: 2340, 2022
Characterization of molecular biomarkers in cerebrospinal fluid and serum of E46K-SNCA mutation carriers.Parkinsonism & related disorders, , Volume: 96, 2022
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Distinct Aβ pathology in the olfactory bulb and olfactory deficits in a mouse model of Aβ and α-syn co-pathology.Brain pathology (Zurich, Switzerland), , Volume: 32, Issue:3, 2022
1-Indanone and 1,3-indandione Derivatives as Ligands for Misfolded α-Synuclein Aggregates.ChemMedChem, , 01-19, Volume: 17, Issue:2, 2022
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SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex.Acta neuropathologica communications, , 12-14, Volume: 10, Issue:1, 2022
Axonal degeneration in the anterior insular cortex is associated with Alzheimer's co-pathology in Parkinson's disease and dementia with Lewy bodies.Translational neurodegeneration, , 12-07, Volume: 11, Issue:1, 2022
Cerebrospinal Fluid Alpha-Synuclein Improves the Differentiation between Dementia with Lewy Bodies and Alzheimer's Disease in Clinical Practice.International journal of molecular sciences, , Nov-04, Volume: 23, Issue:21, 2022
AmyP53, a Therapeutic Peptide Candidate for the Treatment of Alzheimer's and Parkinson's Disease: Safety, Stability, Pharmacokinetics Parameters and Nose-to Brain Delivery.International journal of molecular sciences, , Nov-02, Volume: 23, Issue:21, 2022
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[A role of human microbiota in the development of neurodegenerative diseases].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, , Volume: 122, Issue:10, 2022
Liquid-Liquid Phase Separation Promotes Protein Aggregation and Its Implications in Ferroptosis in Parkinson's Disease Dementia.Oxidative medicine and cellular longevity, , Volume: 2022, 2022
Diagnostic value of plasma p-tau181, NfL, and GFAP in a clinical setting cohort of prevalent neurodegenerative dementias.Alzheimer's research & therapy, , 10-12, Volume: 14, Issue:1, 2022
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Biomarkers Related to Synaptic Dysfunction to Discriminate Alzheimer's Disease from Other Neurological Disorders.International journal of molecular sciences, , Sep-16, Volume: 23, Issue:18, 2022
Could Amyloid-β 1-42 or α-Synuclein Interact Directly with Mitochondrial DNA? A Hypothesis.ACS chemical neuroscience, , 10-05, Volume: 13, Issue:19, 2022
Exploring the Paradox of COVID-19 in Neurological Complications with Emphasis on Parkinson's and Alzheimer's Disease.Oxidative medicine and cellular longevity, , Volume: 2022, 2022
Perception of Fragmented Letters by Patients With Pathologically Confirmed Dementia With Lewy Bodies or Alzheimer Disease.Neurology, , 11-01, Volume: 99, Issue:18, 2022
Natural speech markers of Alzheimer's disease co-pathology in Lewy body dementias.Parkinsonism & related disorders, , Volume: 102, 2022
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The Role of Amyloid-β, Tau, and α-Synuclein Proteins as Putative Blood Biomarkers in Patients with Cerebral Amyloid Angiopathy.Journal of Alzheimer's disease : JAD, , Volume: 89, Issue:3, 2022
Modulation of Inflammatory Mediators and Microglial Activation Through Physical Exercise in Alzheimer's and Parkinson's Diseases.Neurochemical research, , Volume: 47, Issue:11, 2022
Dityrosine Cross-links are Present in Alzheimer's Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297-391) In Vitro.Journal of molecular biology, , 10-15, Volume: 434, Issue:19, 2022
Functional Cooperation of α-Synuclein and Tau Is Essential for Proper Corticogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 09-14, Volume: 42, Issue:37, 2022
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Exploring the brain metabolic correlates of process-specific CSF biomarkers in patients with MCI due to Alzheimer's disease: preliminary data.Neurobiology of aging, , Volume: 117, 2022
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Endogenous Human Proteins Interfering with Amyloid Formation.Biomolecules, , 03-14, Volume: 12, Issue:3, 2022
Propagation of tau and α-synuclein in the brain: therapeutic potential of the glymphatic system.Translational neurodegeneration, , 03-21, Volume: 11, Issue:1, 2022
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Structural and Functional Insights into α-Synuclein Fibril Polymorphism.Biomolecules, , 09-28, Volume: 11, Issue:10, 2021
Biomarkers of neurodegeneration and glial activation validated in Alzheimer's disease assessed in longitudinal cerebrospinal fluid samples of Parkinson's disease.PloS one, , Volume: 16, Issue:10, 2021
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Alternative platelet activation pathways and their role in neurodegenerative diseases.Neurobiology of disease, , Volume: 159, 2021
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Lewy Body Pathology: From Amyloidosis to Vesicle Trafficking.Protein and peptide letters, , Volume: 28, Issue:11, 2021
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Different patterns of hippocampal subfield pathology in Lewy body disease and Alzheimer's disease.Neuropathology and applied neurobiology, , Volume: 47, Issue:5, 2021
How gut microbes could drive brain disorders.Nature, , Volume: 590, Issue:7844, 2021
Prion Diseases: A Unique Transmissible Agent or a Model for Neurodegenerative Diseases?Biomolecules, , 02-02, Volume: 11, Issue:2, 2021
Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.Chemical reviews, , 02-24, Volume: 121, Issue:4, 2021
Electrochemical biosensors for biometal-protein interactions in neurodegenerative diseases.Biosensors & bioelectronics, , May-01, Volume: 179, 2021
α-Synuclein Heteromers in Red Blood Cells of Alzheimer's Disease and Lewy Body Dementia Patients.Journal of Alzheimer's disease : JAD, , Volume: 80, Issue:2, 2021
Bispecific Tau Antibodies with Additional Binding to C1q or Alpha-Synuclein.Journal of Alzheimer's disease : JAD, , Volume: 80, Issue:2, 2021
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture.Nature genetics, , Volume: 53, Issue:3, 2021
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Multiple Neurodegenerative Pathologies in an Alzheimer's Disease Patient Treated with Fornical Deep Brain Stimulation.Journal of Alzheimer's disease : JAD, , Volume: 80, Issue:4, 2021
Disrupted metabolic connectivity in dopaminergic and cholinergic networks at different stages of dementia from Scientific reports, , 03-08, Volume: 11, Issue:1, 2021
Clinicopathological correlations and cholinesterase expression in early-onset familial Alzheimer's disease with the presenilin 1 mutation, Leu235Pro.Neurobiology of aging, , Volume: 103, 2021
Amyloid Structural Changes Studied by Infrared Microspectroscopy in Bigenic Cellular Models of Alzheimer's Disease.International journal of molecular sciences, , Mar-26, Volume: 22, Issue:7, 2021
In Vivo Diagnosis of Synucleinopathies: A Comparative Study of Skin Biopsy and RT-QuIC.Neurology, , 05-18, Volume: 96, Issue:20, 2021
Nanoaggregates Derived from Amyloid-beta and Alpha-synuclein Characterized by Sequential Quadruple Force Mapping.Nano letters, , 05-12, Volume: 21, Issue:9, 2021
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Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer's Disease.Neurochemical research, , Volume: 46, Issue:7, 2021
Curcumin: A small molecule with big functionality against amyloid aggregation in neurodegenerative diseases and type 2 diabetes.BioFactors (Oxford, England), , Volume: 47, Issue:4, 2021
Associations of Neuropsychiatric Features with Cerebrospinal Fluid Biomarkers of Amyloidogenesis and Neurodegeneration in Dementia with Lewy Bodies Compared with Alzheimer's Disease and Cognitively Healthy People.Journal of Alzheimer's disease : JAD, , Volume: 81, Issue:3, 2021
Faster disease progression in Parkinson's disease with type 2 diabetes is not associated with increased α-synuclein, tau, amyloid-β or vascular pathology.Neuropathology and applied neurobiology, , Volume: 47, Issue:7, 2021
Cerebrospinal fluid α synuclein concentrations in patients with positive AD biomarkers and extrapyramidal symptoms.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 128, Issue:6, 2021
[The role of aluminum and lead in the development of Alzheimer's and Parkinson's diseases].Arkhiv patologii, , Volume: 83, Issue:3, 2021
Neurogranin as a Novel Biomarker in Alzheimer's Disease.Laboratory medicine, , Mar-15, Volume: 52, Issue:2, 2021
Four Common Late-Life Cognitive Trajectories Patterns Associate with Replicable Underlying Neuropathologies.Journal of Alzheimer's disease : JAD, , Volume: 82, Issue:2, 2021
Proteolytic α-Synuclein Cleavage in Health and Disease.International journal of molecular sciences, , May-21, Volume: 22, Issue:11, 2021
How an Infection of Sheep Revealed Prion Mechanisms in Alzheimer's Disease and Other Neurodegenerative Disorders.International journal of molecular sciences, , May-04, Volume: 22, Issue:9, 2021
Green Tea Epigallocatechin-3-gallate (EGCG) Targeting Protein Misfolding in Drug Discovery for Neurodegenerative Diseases.Biomolecules, , 05-20, Volume: 11, Issue:5, 2021
Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates.Journal of neuroinflammation, , Jun-03, Volume: 18, Issue:1, 2021
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New strategies for fluorescently labeling proteins in the study of amyloids.Current opinion in chemical biology, , Volume: 64, 2021
From Kuru to Alzheimer: A personal outlook.Protein science : a publication of the Protein Society, , Volume: 30, Issue:9, 2021
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Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions.Acta neuropathologica communications, , 07-21, Volume: 9, Issue:1, 2021
Mechanistic roles for altered O-GlcNAcylation in neurodegenerative disorders.The Biochemical journal, , 07-30, Volume: 478, Issue:14, 2021
The Association Between Plasma α-Synuclein (α-syn) Protein, Urinary Alzheimer-Associated Neuronal Thread Protein (AD7c-NTP), and Apolipoprotein Epsilon 4 (ApoE ε4) Alleles and Cognitive Decline in 60 Patients with Alzheimer's Disease Compared with 28 Age-Medical science monitor : international medical journal of experimental and clinical research, , Jul-27, Volume: 27, 2021
Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer's continuum.Alzheimer's research & therapy, , 08-05, Volume: 13, Issue:1, 2021
Novel blood test for early biomarkers of preeclampsia and Alzheimer's disease.Scientific reports, , 08-05, Volume: 11, Issue:1, 2021
Ultrasensitive techniques and protein misfolding amplification assays for biomarker-guided reconceptualization of Alzheimer's and other neurodegenerative diseases.Expert review of neurotherapeutics, , Volume: 21, Issue:9, 2021
Queuine, a bacterial-derived hypermodified nucleobase, shows protection in in vitro models of neurodegeneration.PloS one, , Volume: 16, Issue:8, 2021
Modulating α-Synuclein Liquid-Liquid Phase Separation.Biochemistry, , 12-07, Volume: 60, Issue:48, 2021
Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies.Acta neuropathologica communications, , 08-28, Volume: 9, Issue:1, 2021
Clinicopathological investigation of the background of cognitive decline in elderly schizophrenia.Acta neuropsychiatrica, , Volume: 33, Issue:2, 2021
α-Synuclein modulates tau spreading in mouse brains.The Journal of experimental medicine, , 01-04, Volume: 218, Issue:1, 2021
Sildenafil ameliorates Alzheimer disease via the modulation of vascular endothelial growth factor and vascular cell adhesion molecule-1 in rats.Human & experimental toxicology, , Volume: 40, Issue:4, 2021
Microglia is associated with p-Tau aggregates in the olfactory bulb of patients with neurodegenerative diseases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 42, Issue:4, 2021
STochastic Optical Reconstruction Microscopy (STORM) reveals the nanoscale organization of pathological aggregates in human brain.Neuropathology and applied neurobiology, , Volume: 47, Issue:1, 2021
Effect of Ionic Strength on Thioflavin-T Affinity to Amyloid Fibrils and Its Fluorescence Intensity.International journal of molecular sciences, , Nov-24, Volume: 21, Issue:23, 2020
The value of cerebrospinal fluid α-synuclein and the tau/α-synuclein ratio for diagnosis of neurodegenerative disorders with Lewy pathology.European journal of neurology, , Volume: 27, Issue:1, 2020
Evaluating the Effects of Grain of Isogenic Wheat Lines Differing in the Content of Anthocyanins in Mouse Models of Neurodegenerative Disorders.Nutrients, , Dec-18, Volume: 12, Issue:12, 2020
Complex Interaction between Resident Microbiota and Misfolded Proteins: Role in Neuroinflammation and Neurodegeneration.Cells, , 11-13, Volume: 9, Issue:11, 2020
Spearmint Extract Containing Rosmarinic Acid Suppresses Amyloid Fibril Formation of Proteins Associated with Dementia.Nutrients, , Nov-13, Volume: 12, Issue:11, 2020
Multiplicity of α-Synuclein Aggregated Species and Their Possible Roles in Disease.International journal of molecular sciences, , Oct-28, Volume: 21, Issue:21, 2020
Rapid Structural, Kinetic, and Immunochemical Analysis of Alpha-Synuclein Oligomers in Solution.Nano letters, , 11-11, Volume: 20, Issue:11, 2020
Mixed Brain Pathology Is the Most Common Cause of Cognitive Impairment in the Elderly.Journal of Alzheimer's disease : JAD, , Volume: 78, Issue:1, 2020
Microglia modulate neurodegeneration in Alzheimer's and Parkinson's diseases.Science (New York, N.Y.), , 10-02, Volume: 370, Issue:6512, 2020
Differential diagnostic value of total alpha-synuclein assay in the cerebrospinal fluid between Alzheimer's disease and dementia with Lewy bodies from the prodromal stage.Alzheimer's research & therapy, , 09-29, Volume: 12, Issue:1, 2020
Associations of sleep characteristics with alpha-synuclein in cerebrospinal fluid in older adults.Annals of clinical and translational neurology, , Volume: 7, Issue:10, 2020
Association of APOE e2 genotype with Alzheimer's and non-Alzheimer's neurodegenerative pathologies.Nature communications, , 09-18, Volume: 11, Issue:1, 2020
Hippocampal subfield pathologic burden in Lewy body diseases vs. Alzheimer's disease.Neuropathology and applied neurobiology, , Volume: 46, Issue:7, 2020
Quadruple abnormal protein aggregates in brainstem pathology and exogenous metal-rich magnetic nanoparticles (and engineered Ti-rich nanorods). The substantia nigrae is a very early target in young urbanites and the gastrointestinal tract a key brainstem Environmental research, , Volume: 191, 2020
Mangosteen Pericarp and Its Bioactive Xanthones: Potential Therapeutic Value in Alzheimer's Disease, Parkinson's Disease, and Depression with Pharmacokinetic and Safety Profiles.International journal of molecular sciences, , Aug-27, Volume: 21, Issue:17, 2020
Potential Role of Natural Polyphenols against Protein Aggregation Toxicity: In Vitro, In Vivo, and Clinical Studies.ACS chemical neuroscience, , 10-07, Volume: 11, Issue:19, 2020
Discoidin Domain Receptor 1 is a therapeutic target for neurodegenerative diseases.Human molecular genetics, , 10-10, Volume: 29, Issue:17, 2020
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.Scientific reports, , 07-30, Volume: 10, Issue:1, 2020
Somatic mutations in neurodegeneration: An update.Neurobiology of disease, , Volume: 144, 2020
Prolongation of metallothionein induction combats Aß and α-synuclein toxicity in aged transgenic Caenorhabditis elegans.Scientific reports, , 07-16, Volume: 10, Issue:1, 2020
CSF total tau/α-synuclein ratio improved the diagnostic performance for Alzheimer's disease as an indicator of tau phosphorylation.Alzheimer's research & therapy, , 07-13, Volume: 12, Issue:1, 2020
General Aggregation-Induced Emission Probes for Amyloid Inhibitors with Dual Inhibition Capacity against Amyloid β-Protein and α-Synuclein.ACS applied materials & interfaces, , Jul-15, Volume: 12, Issue:28, 2020
Dual Targeting of Monomeric Tau and α-Synuclein Aggregation: A New Multitarget Therapeutic Strategy for Neurodegeneration.ACS chemical neuroscience, , 07-15, Volume: 11, Issue:14, 2020
Application of yeast to studying amyloid and prion diseases.Advances in genetics, , Volume: 105, 2020
Biophysical studies of protein misfolding and aggregation in Quarterly reviews of biophysics, , 06-04, Volume: 49, 2020
Prodromal Intestinal Events in Alzheimer's Disease (AD): Colonic Dysmotility and Inflammation Are Associated with Enteric AD-Related Protein Deposition.International journal of molecular sciences, , May-15, Volume: 21, Issue:10, 2020
Ubiquitin biology in neurodegenerative disorders: From impairment to therapeutic strategies.Ageing research reviews, , Volume: 61, 2020
A new tetra-plex fluorimetric assay for the quantification of cerebrospinal fluid β-amyloid42, total-tau, phospho-tau and α-synuclein in the differential diagnosis of neurodegenerative dementia.Journal of neurology, , Volume: 267, Issue:9, 2020
Calbindin-DCellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , May-02, Volume: 54, Issue:3, 2020
Contribution of mixed pathology to medial temporal lobe atrophy in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 16, Issue:6, 2020
Degree of genetic liability for Alzheimer's disease associated with specific proteomic profiles in cerebrospinal fluid.Neurobiology of aging, , Volume: 93, 2020
Novel biomarkers for the evaluation of aging-induced proteinopathies.Biogerontology, , Volume: 21, Issue:5, 2020
Role of Alcohol Drinking in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis.International journal of molecular sciences, , Mar-27, Volume: 21, Issue:7, 2020
Protein transmission in neurodegenerative disease.Nature reviews. Neurology, , Volume: 16, Issue:4, 2020
Aggregation and Cellular Toxicity of Pathogenic or Non-pathogenic Proteins.Scientific reports, , 03-20, Volume: 10, Issue:1, 2020
Systematic review of gene expression studies in people with Lewy body dementia.Acta neuropsychiatrica, , Volume: 32, Issue:6, 2020
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Choroid plexus volume is associated with levels of CSF proteins: relevance for Alzheimer's and Parkinson's disease.Neurobiology of aging, , Volume: 89, 2020
Synthesis and characterization of high affinity fluorogenic α-synuclein probes.Chemical communications (Cambridge, England), , Mar-24, Volume: 56, Issue:24, 2020
PET Radiopharmaceuticals for Alzheimer's Disease and Parkinson's Disease Diagnosis, the Current and Future Landscape.Molecules (Basel, Switzerland), , Feb-21, Volume: 25, Issue:4, 2020
Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro.Molecules (Basel, Switzerland), , Jan-29, Volume: 25, Issue:3, 2020
Immunotherapy for Parkinson's disease.Neurobiology of disease, , Volume: 137, 2020
Aβ Puts the Alpha in Synuclein.Neuron, , 01-22, Volume: 105, Issue:2, 2020
KDS2010: A Potent Highly Selective and Reversible MAO-B Inhibitor for Alzheimer's Disease.Combinatorial chemistry & high throughput screening, , Volume: 23, Issue:9, 2020
Novel Therapeutics for the Treatment of Alzheimer's and Parkinson's Disease.Current pharmaceutical design, , Volume: 26, Issue:7, 2020
Systematic review of genetic association studies in people with Lewy body dementia.International journal of geriatric psychiatry, , Volume: 35, Issue:5, 2020
Interactions between Soluble Species of β-Amyloid and α-Synuclein Promote Oligomerization while Inhibiting Fibrillization.Biochemistry, , 02-04, Volume: 59, Issue:4, 2020
CSF or serum neurofilament light added to α-Synuclein panel discriminates Parkinson's from controls.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:2, 2020
Small vessel disease pathological changes in neurodegenerative and vascular dementias concomitant with autonomic dysfunction.Brain pathology (Zurich, Switzerland), , Volume: 30, Issue:1, 2020
Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer's and Parkinson disease pathology.Biochimica et biophysica acta. Molecular basis of disease, , 08-01, Volume: 1865, Issue:8, 2019
A Genome-Wide Association Study of α-Synuclein Levels in Cerebrospinal Fluid.Neurotoxicity research, , Volume: 35, Issue:1, 2019
The toxin MPTP generates similar cognitive and locomotor deficits in hTau and tau knock-out mice.Brain research, , 05-15, Volume: 1711, 2019
Investigating the Association Between Verbal Forgetting and Pathological Markers of Alzheimer's and Lewy Body Diseases.Journal of Alzheimer's disease : JAD, , Volume: 70, Issue:3, 2019
Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes.Nature neuroscience, , Volume: 22, Issue:7, 2019
Dementia with lewy bodies: GBA1 mutations are associated with cerebrospinal fluid alpha-synuclein profile.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:7, 2019
α-synuclein in the pathophysiology of Alzheimer's disease.Molecular neurodegeneration, , 06-11, Volume: 14, Issue:1, 2019
Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 15, Issue:1, 2019
Transcriptomics in tissue glucocorticoid sensitivity.European journal of clinical investigation, , Volume: 49, Issue:8, 2019
LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?Biochemical Society transactions, , 06-28, Volume: 47, Issue:3, 2019
Measurement of CSF α-synuclein improves early differential diagnosis of mild cognitive impairment due to Alzheimer's disease.Journal of neurochemistry, , Volume: 150, Issue:2, 2019
The Toxicity of Misfolded Protein Oligomers Is Independent of Their Secondary Structure.ACS chemical biology, , 07-19, Volume: 14, Issue:7, 2019
Differential diagnosis between Alzheimer's disease and other dementias: Role of cerebrospinal fluid biomarkers.Clinical biochemistry, , Volume: 72, 2019
An attempt to elucidate the role of iron and zinc ions in development of Alzheimer's and Parkinson's diseases.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 111, 2019
Potential Diagnostic Value of Red Blood Cells α-Synuclein Heteroaggregates in Alzheimer's Disease.Molecular neurobiology, , Volume: 56, Issue:9, 2019
rAAV-based brain slice culture models of Alzheimer's and Parkinson's disease inclusion pathologies.The Journal of experimental medicine, , 03-04, Volume: 216, Issue:3, 2019
Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases.Neurology, , 02-12, Volume: 92, Issue:7, 2019
The prion-like propagation hypothesis in Alzheimer's and Parkinson's disease.Current opinion in neurology, , Volume: 32, Issue:2, 2019
Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration.Brain pathology (Zurich, Switzerland), , Volume: 29, Issue:1, 2019
Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders.Annals of neurology, , Volume: 85, Issue:2, 2019
Associations Between APOE Variants, Tau and α-Synuclein.Advances in experimental medicine and biology, , Volume: 1184, 2019
Late-Life Depression and Lewy Body Disease.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, , Volume: 27, Issue:3, 2019
Metal ions and degenerative diseases.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, , Volume: 24, Issue:8, 2019
[The Propagation Hypothesis of Prion-like Protein Agregates in Neurodegenerative Diseases].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 71, Issue:11, 2019
Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies.Cells, , 10-10, Volume: 8, Issue:10, 2019
Redox active metals in neurodegenerative diseases.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, , Volume: 24, Issue:8, 2019
Million-fold sensitivity enhancement in proteopathic seed amplification assays for biospecimens by Hofmeister ion comparisons.Proceedings of the National Academy of Sciences of the United States of America, , 11-12, Volume: 116, Issue:46, 2019
Lower nucleus accumbens α-synuclein load and D3 receptor levels in Parkinson's disease with impulsive compulsive behaviours.Brain : a journal of neurology, , 11-01, Volume: 142, Issue:11, 2019
α-Synuclein RT-QuIC assay in cerebrospinal fluid of patients with dementia with Lewy bodies.Annals of clinical and translational neurology, , Volume: 6, Issue:10, 2019
Simultaneous quantification of tau and α-synuclein in cerebrospinal fluid by high-resolution mass spectrometry for differentiation of Lewy Body Dementia from Alzheimer's Disease and controls.The Analyst, , Oct-22, Volume: 144, Issue:21, 2019
Aβ, Tau, and α-Synuclein aggregation and integrated role of PARK2 in the regulation and clearance of toxic peptides.Neuropeptides, , Volume: 78, 2019
Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression.Acta neuropathologica communications, , 09-02, Volume: 7, Issue:1, 2019
High lithium levels in tobacco may account for reduced incidences of both Parkinson's disease and melanoma in smokers through enhanced β-catenin-mediated activity.Medical hypotheses, , Volume: 131, 2019
Roles for the adaptive immune system in Parkinson's and Alzheimer's diseases.Current opinion in immunology, , Volume: 59, 2019
Erythrocytes as Biomarkers for Dementia: Analysis of Protein Content and Alpha-Synuclein.Journal of Alzheimer's disease : JAD, , 08-12, Volume: 71, Issue:2, 2019
Alzheimer's disease and other neurodegenerative dementias in comorbidity: A clinical and neuropathological overview.Clinical biochemistry, , Volume: 73, 2019
Ultrasensitive Detection of Aggregated α-Synuclein in Glial Cells, Human Cerebrospinal Fluid, and Brain Tissue Using the RT-QuIC Assay: New High-Throughput Neuroimmune Biomarker Assay for Parkinsonian Disorders.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 14, Issue:3, 2019
Effects of single and combined immunotherapy approach targeting amyloid β protein and α-synuclein in a dementia with Lewy bodies-like model.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 15, Issue:9, 2019
Twendee X Ameliorates Phosphorylated Tau, α-Synuclein and Neurovascular Dysfunction in Alzheimer's Disease Transgenic Mice With Chronic Cerebral Hypoperfusion.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, , Volume: 28, Issue:10, 2019
AD biomarkers at AAIC 2019.Nature reviews. Neurology, , Volume: 15, Issue:9, 2019
Heterogeneity in α-synuclein subtypes and their expression in cortical brain tissue lysates from Lewy body diseases and Alzheimer's disease.Neuropathology and applied neurobiology, , Volume: 45, Issue:6, 2019
Alzheimer's disease and alpha-synuclein pathology in the olfactory bulbs of infants, children, teens and adults ≤ 40 years in Metropolitan Mexico City. APOE4 carriers at higher risk of suicide accelerate their olfactory bulb pathology.Environmental research, , Volume: 166, 2018
A Longitudinal Study of Total and Phosphorylated α-Synuclein with Other Biomarkers in Cerebrospinal Fluid of Alzheimer's Disease and Mild Cognitive Impairment.Journal of Alzheimer's disease : JAD, , Volume: 61, Issue:4, 2018
α-Synuclein species as potential cerebrospinal fluid biomarkers for dementia with lewy bodies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:11, 2018
Sex differences in Alzheimer's disease and common neuropathologies of aging.Acta neuropathologica, , Volume: 136, Issue:6, 2018
Lewy Body Dementia.Clinics in geriatric medicine, , Volume: 34, Issue:4, 2018
The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease.Acta neuropathologica communications, , 11-26, Volume: 6, Issue:1, 2018
Cerebral inoculation of human A53T α-synuclein reduces spatial memory decline and amyloid-β aggregation in APP/PS1 transgenic mice of Alzheimer's disease.Brain research bulletin, , Volume: 143, 2018
Possible Role of the Polyglutamine Elongation in Evolution of Amyloid-Related Evolvability.Journal of Huntington's disease, , Volume: 7, Issue:4, 2018
A refined concept: α-synuclein dysregulation disease.Neurochemistry international, , Volume: 119, 2018
Relationships between lewy and tau pathologies in 375 consecutive non-Alzheimer's olfactory bulbs.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:2, 2018
Insights into the Molecular Mechanisms of Alzheimer's and Parkinson's Diseases with Molecular Simulations: Understanding the Roles of Artificial and Pathological Missense Mutations in Intrinsically Disordered Proteins Related to Pathology.International journal of molecular sciences, , Jan-24, Volume: 19, Issue:2, 2018
Endogenous Murine Amyloid-β Peptide Assembles into Aggregates in the Aged C57BL/6J Mouse Suggesting These Animals as a Model to Study Pathogenesis of Amyloid-β Plaque Formation.Journal of Alzheimer's disease : JAD, , Volume: 61, Issue:4, 2018
Synergistic Amyloid Switch Triggered by Early Heterotypic Oligomerization of Intrinsically Disordered α-Synuclein and Tau.Journal of molecular biology, , 08-03, Volume: 430, Issue:16, 2018
Bidirectional modulation of Alzheimer phenotype by alpha-synuclein in mice and primary neurons.Acta neuropathologica, , Volume: 136, Issue:4, 2018
The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration.FEBS letters, , Volume: 592, Issue:23, 2018
Improving the identification of dementia with Lewy bodies in the context of an Alzheimer's-type dementia.Alzheimer's research & therapy, , 03-01, Volume: 10, Issue:1, 2018
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells.Chembiochem : a European journal of chemical biology, , 10-04, Volume: 19, Issue:19, 2018
Association of cerebrospinal fluid α-synuclein with total and phospho-tauAlzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 14, Issue:12, 2018
Shedding light on aberrant interactions - a review of modern tools for studying protein aggregates.The FEBS journal, , Volume: 285, Issue:19, 2018
Autopsied centenarian case of Alzheimer's disease combined with hippocampal sclerosis, TDP-43, and α-synuclein pathologies.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 38, Issue:6, 2018
Neuropsychiatric symptoms and α-Synuclein profile of patients with Parkinson's disease dementia, dementia with Lewy bodies and Alzheimer's disease.Journal of neurology, , Volume: 265, Issue:10, 2018
Quinolinic Acid Amyloid-like Fibrillar Assemblies Seed α-Synuclein Aggregation.Journal of molecular biology, , 10-12, Volume: 430, Issue:20, 2018
Implications of Metal Binding and Asparagine Deamidation for Amyloid Formation.International journal of molecular sciences, , Aug-19, Volume: 19, Issue:8, 2018
Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 14, Issue:8, 2018
Diagnostic value of cerebrospinal fluid alpha-synuclein in dementia with Lewy body.Geriatrie et psychologie neuropsychiatrie du vieillissement, , Sep-01, Volume: 16, Issue:3, 2018
Novel monoclonal antibodies targeting the microtubule-binding domain of human tau.PloS one, , Volume: 13, Issue:4, 2018
Distinct functional roles of Vps41-mediated neuroprotection in Alzheimer's and Parkinson's disease models of neurodegeneration.Human molecular genetics, , 12-15, Volume: 27, Issue:24, 2018
Beneficial Effects of Green Tea Catechins on Neurodegenerative Diseases.Molecules (Basel, Switzerland), , May-29, Volume: 23, Issue:6, 2018
Negative 11C-PIB PET Predicts Lack of Alzheimer's Disease Pathology in Postmortem Examination.Journal of Alzheimer's disease : JAD, , Volume: 63, Issue:1, 2018
Associations between ZnT3, tau pathology, agitation, and delusions in dementia.International journal of geriatric psychiatry, , Volume: 33, Issue:8, 2018
Analysis of age-related changes in psychosine metabolism in the human brain.PloS one, , Volume: 13, Issue:2, 2018
Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated.Brain : a journal of neurology, , 07-01, Volume: 141, Issue:7, 2018
Long Road to Ruin: Noradrenergic Dysfunction in Neurodegenerative Disease.Trends in neurosciences, , Volume: 41, Issue:4, 2018
Lack of pathogenic potential of peripheral α-synuclein aggregates from Parkinson's disease patients.Acta neuropathologica communications, , 02-08, Volume: 6, Issue:1, 2018
Parkinson's disease and Alzheimer's disease: a Mendelian randomization study.BMC medical genetics, , 12-31, Volume: 19, Issue:Suppl 1, 2018
Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC.Acta neuropathologica communications, , 02-09, Volume: 6, Issue:1, 2018
Alternative hypotheses related to Alzheimer's disease.Bratislavske lekarske listy, , Volume: 119, Issue:4, 2018
Methylation changes and aberrant expression of FGFR3 in Lewy body disease neurons.Brain research, , 10-15, Volume: 1697, 2018
Alzheimer disease biomarkers and synucleinopathy.Neurology, , 03-20, Volume: 90, Issue:12, 2018
Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases.The FEBS journal, , Volume: 285, Issue:19, 2018
Modulation of Parkinson's Disease Associated Protein Rescues Alzheimer's Disease Degeneration.Journal of Alzheimer's disease : JAD, , Volume: 55, Issue:1, 2017
Protein aggregation and neurodegeneration in prototypical neurodegenerative diseases: Examples of amyloidopathies, tauopathies and synucleinopathies.Progress in neurobiology, , Volume: 155, 2017
MOAG-4 promotes the aggregation of α-synuclein by competing with self-protective electrostatic interactions.The Journal of biological chemistry, , 05-19, Volume: 292, Issue:20, 2017
Lack of spontaneous age-related brain pathology in Octodon degus: a reappraisal of the model.Scientific reports, , 04-04, Volume: 7, 2017
Changes in CD200 and intercellular adhesion molecule-1 (ICAM-1) levels in brains of Lewy body disorder cases are associated with amounts of Alzheimer's pathology not α-synuclein pathology.Neurobiology of aging, , Volume: 54, 2017
Regional Overlap of Pathologies in Lewy Body Disorders.Journal of neuropathology and experimental neurology, , 03-01, Volume: 76, Issue:3, 2017
Novel Benzothiazole Derivatives as Fluorescent Probes for Detection of β-Amyloid and α-Synuclein Aggregates.ACS chemical neuroscience, , 08-16, Volume: 8, Issue:8, 2017
Amygdala α-Synuclein Pathology in the Population-Based Vantaa 85+ Study.Journal of Alzheimer's disease : JAD, , Volume: 58, Issue:3, 2017
Higher levels of myelin phospholipids in brains of neuronal α-Synuclein transgenic mice precede myelin loss.Acta neuropathologica communications, , 05-08, Volume: 5, Issue:1, 2017
Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits.Proceedings of the National Academy of Sciences of the United States of America, , 06-06, Volume: 114, Issue:23, 2017
Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology.Acta neuropathologica communications, , 06-09, Volume: 5, Issue:1, 2017
Human cyclophilin 40 unravels neurotoxic amyloids.PLoS biology, , Volume: 15, Issue:6, 2017
A new potential biomarker for dementia with Lewy bodies: Skin nerve α-synuclein deposits.Neurology, , Jul-25, Volume: 89, Issue:4, 2017
Physico-Pathologic Mechanisms Involved in Neurodegeneration: Misfolded Protein-Plasma Membrane Interactions.Neuron, , Jul-05, Volume: 95, Issue:1, 2017
Dementia: Skin α-synuclein deposits - a new biomarker for DLB?Nature reviews. Neurology, , Volume: 13, Issue:9, 2017
Differential role of CSF fatty acid binding protein 3, α-synuclein, and Alzheimer's disease core biomarkers in Lewy body disorders and Alzheimer's dementia.Alzheimer's research & therapy, , Jul-28, Volume: 9, Issue:1, 2017
A meta-analysis and review examining a possible role for oxidative stress and singlet oxygen in diverse diseases.The Biochemical journal, , 08-02, Volume: 474, Issue:16, 2017
Small-molecule PET Tracers for Imaging Proteinopathies.Seminars in nuclear medicine, , Volume: 47, Issue:5, 2017
Discoidin domain receptor inhibition reduces neuropathology and attenuates inflammation in neurodegeneration models.Journal of neuroimmunology, , 10-15, Volume: 311, 2017
Vaccination strategies in tauopathies and synucleinopathies.Journal of neurochemistry, , Volume: 143, Issue:5, 2017
The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome.PloS one, , Volume: 12, Issue:9, 2017
Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer's disease.Scientific reports, , 01-10, Volume: 7, 2017
Quantitative neuropathology: an update on automated methodologies and implications for large scale cohorts.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 124, Issue:6, 2017
Synthesis and biological evaluation of novel radioiodinated benzimidazole derivatives for imaging α-synuclein aggregates.Bioorganic & medicinal chemistry, , 12-15, Volume: 25, Issue:24, 2017
Synaptic phosphorylated α-synuclein in dementia with Lewy bodies.Brain : a journal of neurology, , Dec-01, Volume: 140, Issue:12, 2017
A preclinical screen to evaluate pharmacotherapies for the treatment of agitation in dementia.Behavioural pharmacology, , Volume: 28, Issue:2 and 3-Sp, 2017
α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies.Nature medicine, , Feb-07, Volume: 23, Issue:2, 2017
Increased Transforming Growth Factor β2 in the Neocortex of Alzheimer's Disease and Dementia with Lewy Bodies is Correlated with Disease Severity and Soluble Aβ42 Load.Journal of Alzheimer's disease : JAD, , Volume: 56, Issue:1, 2017
The Clinical Use of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease Diagnosis: The Italian Selfie.Journal of Alzheimer's disease : JAD, , Volume: 55, Issue:4, 2017
Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders.Pharmacology & therapeutics, , Volume: 172, 2017
Extracts from two ubiquitous Mediterranean plants ameliorate cellular and animal models of neurodegenerative proteinopathies.Neuroscience letters, , 01-18, Volume: 638, 2017
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Neuronal Loss and Α-Synuclein Pathology in the Superior Colliculus and Its Relationship to Visual Hallucinations in Dementia with Lewy Bodies.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, , Volume: 25, Issue:6, 2017
Evaluation of a DNA Aβ42 Vaccine in Aged NZW Rabbits: Antibody Kinetics and Immune Profile after Intradermal Immunization with Full-Length DNA Aβ42 Trimer.Journal of Alzheimer's disease : JAD, , Volume: 57, Issue:1, 2017
Lysosomal dysfunction in the brain of a mouse model with intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein.Molecular psychiatry, , Volume: 22, Issue:7, 2017
Unfolded protein response is activated in Lewy body dementias.Neuropathology and applied neurobiology, , Volume: 42, Issue:4, 2016
Oligomeric α-synuclein and β-amyloid variants as potential biomarkers for Parkinson's and Alzheimer's diseases.The European journal of neuroscience, , Volume: 43, Issue:1, 2016
Detection of Helical Intermediates During Amyloid Formation by Intrinsically Disordered Polypeptides and Proteins.Methods in molecular biology (Clifton, N.J.), , Volume: 1345, 2016
Cell Models to Study Cell-to-Cell Transmission of α-Synuclein.Methods in molecular biology (Clifton, N.J.), , Volume: 1345, 2016
Non-Amyloid-β Component of Human α-Synuclein Oligomers Induces Formation of New Aβ Oligomers: Insight into the Mechanisms That Link Parkinson's and Alzheimer's Diseases.ACS chemical neuroscience, , Jan-20, Volume: 7, Issue:1, 2016
Broad neutralization of calcium-permeable amyloid pore channels with a chimeric Alzheimer/Parkinson peptide targeting brain gangliosides.Biochimica et biophysica acta, , Volume: 1862, Issue:2, 2016
The Anti-Amyloid-β Monoclonal Antibody 4G8 Recognizes a Generic Sequence-Independent Epitope Associated with α-Synuclein and Islet Amyloid Polypeptide Amyloid Fibrils.Journal of Alzheimer's disease : JAD, , Volume: 50, Issue:2, 2016
Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology.Acta neuropathologica, , Volume: 131, Issue:3, 2016
Altered Levels of Visinin-Like Protein 1 Correspond to Regional Neuronal Loss in Alzheimer Disease and Frontotemporal Lobar Degeneration.Journal of neuropathology and experimental neurology, , Volume: 75, Issue:2, 2016
Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson's disease.Molecular neurodegeneration, , Jan-19, Volume: 11, 2016
Editorial overview: Neurobiology of disease.Current opinion in neurobiology, , Volume: 36, 2016
Stabilization of α-Synuclein Fibril Clusters Prevents Fragmentation and Reduces Seeding Activity and Toxicity.Biochemistry, , Feb-02, Volume: 55, Issue:4, 2016
Lewy- and Alzheimer-type pathologies in midbrain and cerebellum across the Lewy body disorders spectrum.Neuropathology and applied neurobiology, , Volume: 42, Issue:5, 2016
TDP-43 in the olfactory bulb in Alzheimer's disease.Neuropathology and applied neurobiology, , Volume: 42, Issue:4, 2016
Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer's and Parkinson's Disease.International journal of molecular sciences, , Feb-06, Volume: 17, Issue:2, 2016
A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins.ACS combinatorial science, , Mar-14, Volume: 18, Issue:3, 2016
Glycation in Parkinson's disease and Alzheimer's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:6, 2016
Subgroup differences in 'brain-type' transferrin and α-synuclein in Parkinson's disease and multiple system atrophy.Journal of biochemistry, , Volume: 160, Issue:2, 2016
Altered Proteins in the Aging Brain.Journal of neuropathology and experimental neurology, , Volume: 75, Issue:4, 2016
The red-hot debate about transmissible Alzheimer's.Nature, , Mar-17, Volume: 531, Issue:7594, 2016
Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons.Proceedings of the National Academy of Sciences of the United States of America, , Apr-05, Volume: 113, Issue:14, 2016
Oligomeropathies and pathogenesis of Alzheimer and Parkinson's diseases.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:6, 2016
Brain Atrophy of Secondary REM-Sleep Behavior Disorder in Neurodegenerative Disease.Journal of Alzheimer's disease : JAD, , 04-05, Volume: 52, Issue:3, 2016
Coordination and redox properties of copper interaction with α-synuclein.Journal of inorganic biochemistry, , Volume: 163, 2016
A First Tetraplex Assay for the Simultaneous Quantification of Total α-Synuclein, Tau, β-Amyloid42 and DJ-1 in Human Cerebrospinal Fluid.PloS one, , Volume: 11, Issue:4, 2016
Analysis of primary visual cortex in dementia with Lewy bodies indicates GABAergic involvement associated with recurrent complex visual hallucinations.Acta neuropathologica communications, , 06-30, Volume: 4, Issue:1, 2016
Interactions Between α-Synuclein and Tau Protein: Implications to Neurodegenerative Disorders.Journal of molecular neuroscience : MN, , Volume: 60, Issue:3, 2016
Alpha-, Beta-, and Gamma-synuclein Quantification in Cerebrospinal Fluid by Multiple Reaction Monitoring Reveals Increased Concentrations in Alzheimer's and Creutzfeldt-Jakob Disease but No Alteration in Synucleinopathies.Molecular & cellular proteomics : MCP, , Volume: 15, Issue:10, 2016
Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 07-27, Volume: 36, Issue:30, 2016
Elevated mRNA Expression and Low Methylation of SNCA in Japanese Alzheimer's Disease Subjects.Journal of Alzheimer's disease : JAD, , 10-18, Volume: 54, Issue:4, 2016
Aged Lewis rats exposed to low and moderate doses of rotenone are a good model for studying the process of protein aggregation and its effects upon central nervous system cell physiology.Arquivos de neuro-psiquiatria, , Volume: 74, Issue:9, 2016
Cerebrospinal Fluid Biomarkers in Highly Exposed PM2.5 Urbanites: The Risk of Alzheimer's and Parkinson's Diseases in Young Mexico City Residents.Journal of Alzheimer's disease : JAD, , 09-06, Volume: 54, Issue:2, 2016
Pathogenic mechanisms of prion protein, amyloid-β and α-synuclein misfolding: the prion concept and neurotoxicity of protein oligomers.Journal of neurochemistry, , Volume: 139, Issue:2, 2016
Potential Pathways of Abnormal Tau and α-Synuclein Dissemination in Sporadic Alzheimer's and Parkinson's Diseases.Cold Spring Harbor perspectives in biology, , Nov-01, Volume: 8, Issue:11, 2016
TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau.eLife, , 10-25, Volume: 5, 2016
[A Therapeutic Target for Inhibition of Neurodegeneration: Autophagy].Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova, , Volume: 66, Issue:5, 2016
Patterns of Tau and α-Synuclein Pathology in the Visual System.Journal of Parkinson's disease, , Volume: 5, Issue:2, 2015
Neuropathologically mixed Alzheimer's and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes.Acta neuropathologica, , Volume: 129, Issue:5, 2015
Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.Experimental & molecular medicine, , Mar-13, Volume: 47, 2015
Use of CSF α-synuclein in the differential diagnosis between Alzheimer's disease and other neurodegenerative disorders.International psychogeriatrics, , Volume: 27, Issue:9, 2015
α-Synuclein pathology accumulates in sacral spinal visceral sensory pathways.Annals of neurology, , Volume: 78, Issue:1, 2015
Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology.Neurobiology of disease, , Volume: 79, 2015
Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth.Scientific reports, , May-28, Volume: 5, 2015
A cytosine-thymine (CT)-rich haplotype in intron 4 of SNCA confers risk for Lewy body pathology in Alzheimer's disease and affects SNCA expression.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 11, Issue:10, 2015
Influence of Lentiviral β-Synuclein Overexpression in the Hippocampus of a Transgenic Mouse Model of Alzheimer's Disease on Amyloid Precursor Protein Metabolism and Pathology.Neuro-degenerative diseases, , Volume: 15, Issue:4, 2015
Quantification of CSF biomarkers using an electrochemiluminescence-based detection system in the differential diagnosis of AD and sCJD.Journal of neurology, , Volume: 262, Issue:10, 2015
Opposing effects of APP/PS1 and TrkB.T1 genotypes on midbrain dopamine neurons and stimulated dopamine release in vivo.Brain research, , Oct-05, Volume: 1622, 2015
NEURODEGENERATION. Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein.Science (New York, N.Y.), , Aug-07, Volume: 349, Issue:6248, 2015
Heroin abuse exaggerates age-related deposition of hyperphosphorylated tau and p62-positive inclusions.Neurobiology of aging, , Volume: 36, Issue:11, 2015
Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways.BMC neuroscience, , Oct-23, Volume: 16, 2015
[Histopathological and immunohistochemical study of spinal cord tissues in neurodegenerative diseases].Zhonghua bing li xue za zhi = Chinese journal of pathology, , Volume: 44, Issue:8, 2015
Sensitive Detection of Proteopathic Seeding Activity with FRET Flow Cytometry.Journal of visualized experiments : JoVE, , Dec-08, Issue:106, 2015
Early Stage of Progressive Supranuclear Palsy: A Neuropathological Study of 324 Consecutive Autopsy Cases.Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, , Volume: 82, Issue:6, 2015
Intracellular screening of a peptide library to derive a potent peptide inhibitor of α-synuclein aggregation.The Journal of biological chemistry, , Mar-20, Volume: 290, Issue:12, 2015
Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap?Experimental gerontology, , Volume: 68, 2015
I716F AβPP mutation associates with the deposition of oligomeric pyroglutamate amyloid-β and α-synucleinopathy with Lewy bodies.Journal of Alzheimer's disease : JAD, , Volume: 44, Issue:1, 2015
Cerebrospinal fluid α-synuclein and Lewy body-like symptoms in normal controls, mild cognitive impairment, and Alzheimer's disease.Journal of Alzheimer's disease : JAD, , Volume: 43, Issue:3, 2015
Neuropathological investigation of hypocretin expression in brains of dementia with Lewy bodies.Neuroscience letters, , May-21, Volume: 569, 2014
Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo.Brain : a journal of neurology, , Volume: 137, Issue:Pt 5, 2014
A generic method for design of oligomer-specific antibodies.PloS one, , Volume: 9, Issue:3, 2014
Protein folding and misfolding in the neurodegenerative disorders: a review.Revue neurologique, , Volume: 170, Issue:3, 2014
Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD.Acta neuropathologica, , Volume: 127, Issue:4, 2014
Increased CSF α-synuclein levels in Alzheimer's disease: correlation with tau levels.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 10, Issue:5 Suppl, 2014
Predictive association of copper metabolism proteins with Alzheimer's disease and Parkinson's disease: a preliminary perspective.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, , Volume: 27, Issue:1, 2014
Increased amoeboid microglial density in the olfactory bulb of Parkinson's and Alzheimer's patients.Brain pathology (Zurich, Switzerland), , Volume: 24, Issue:2, 2014
[Expression of proteins related neurodegeneration in autopsy brains of the aged].Zhonghua bing li xue za zhi = Chinese journal of pathology, , Volume: 43, Issue:10, 2014
Accumulation of α-synuclein in dementia with Lewy bodies is associated with decline in the α-synuclein-degrading enzymes kallikrein-6 and calpain-1.Acta neuropathologica communications, , Dec-05, Volume: 2, 2014
Monoclonal antibodies against Aβ42 fibrils distinguish multiple aggregation state polymorphisms in vitro and in Alzheimer disease brain.The Journal of biological chemistry, , Nov-14, Volume: 289, Issue:46, 2014
Protein misfolding and aggregation in Alzheimer's disease and type 2 diabetes mellitus.CNS & neurological disorders drug targets, , Volume: 13, Issue:7, 2014
Cross dimerization of amyloid-β and αsynuclein proteins in aqueous environment: a molecular dynamics simulations study.PloS one, , Volume: 9, Issue:9, 2014
Molecular inscription of environmental information into protein suprastructures: temperature effects on unit assembly of α-synuclein oligomers into polymorphic amyloid fibrils.The Biochemical journal, , Dec-01, Volume: 464, Issue:2, 2014
APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease.JAMA neurology, , Volume: 71, Issue:11, 2014
Biochemical assessment of precuneus and posterior cingulate gyrus in the context of brain aging and Alzheimer's disease.PloS one, , Volume: 9, Issue:8, 2014
Deciphering the glycolipid code of Alzheimer's and Parkinson's amyloid proteins allowed the creation of a universal ganglioside-binding peptide.PloS one, , Volume: 9, Issue:8, 2014
Amyloid-β oligomers as a template for secondary amyloidosis in Alzheimer's disease.Neurobiology of disease, , Volume: 71, 2014
Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies.Acta neuropathologica, , Volume: 128, Issue:5, 2014
Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques.Neurobiology of disease, , Volume: 71, 2014
Is there a risk of prion-like disease transmission by Alzheimer- or Parkinson-associated protein particles?Acta neuropathologica, , Volume: 128, Issue:4, 2014
Flow cytometry analysis of synaptosomes from post-mortem human brain reveals changes specific to Lewy body and Alzheimer's disease.Laboratory investigation; a journal of technical methods and pathology, , Volume: 94, Issue:10, 2014
Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies.Human molecular genetics, , Dec-01, Volume: 23, Issue:23, 2014
Beta-amyloid, phospho-tau and alpha-synuclein deposits similar to those in the brain are not identified in the eyes of Alzheimer's and Parkinson's disease patients.Brain pathology (Zurich, Switzerland), , Volume: 24, Issue:1, 2014
Convergence of pathology in dementia with Lewy bodies and Alzheimer's disease: a role for the novel interaction of alpha-synuclein and presenilin 1 in disease.Brain : a journal of neurology, , Volume: 137, Issue:Pt 7, 2014
Prions: generation and spread versus neurotoxicity.The Journal of biological chemistry, , Jul-18, Volume: 289, Issue:29, 2014
Prion-like properties of Tau protein: the importance of extracellular Tau as a therapeutic target.The Journal of biological chemistry, , Jul-18, Volume: 289, Issue:29, 2014
Mouse models for studying the formation and propagation of prions.The Journal of biological chemistry, , Jul-18, Volume: 289, Issue:29, 2014
The genetic contributions of SNCA and LRRK2 genes to Lewy Body pathology in Alzheimer's disease.Human molecular genetics, , Sep-15, Volume: 23, Issue:18, 2014
Psychotic Alzheimer's disease is associated with gender-specific tau phosphorylation abnormalities.Neurobiology of aging, , Volume: 35, Issue:9, 2014
Sphingosine kinases modulate the secretion of amyloid β precursor protein from SH-SY5Y neuroblastoma cells: the role of α-synuclein.Folia neuropathologica, , Volume: 52, Issue:1, 2014
Changes in amyloid-β and Tau in the cerebrospinal fluid of transgenic mice overexpressing amyloid precursor protein.Science translational medicine, , Jul-17, Volume: 5, Issue:194, 2013
The diagnostic utility of cerebrospinal fluid alpha-synuclein analysis in dementia with Lewy bodies - a systematic review and meta-analysis.Parkinsonism & related disorders, , Volume: 19, Issue:10, 2013
The role of α-synuclein in neurodegenerative diseases: from molecular pathways in disease to therapeutic approaches.Current Alzheimer research, , Volume: 10, Issue:6, 2013
Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies.Nature reviews. Neuroscience, , Volume: 14, Issue:9, 2013
Non-Alzheimer neurodegenerative pathologies and their combinations are more frequent than commonly believed in the elderly brain: a community-based autopsy series.Acta neuropathologica, , Volume: 126, Issue:3, 2013
Novel 5' untranslated region directed blockers of iron-regulatory protein-1 dependent amyloid precursor protein translation: implications for down syndrome and Alzheimer's disease.PloS one, , Volume: 8, Issue:7, 2013
Treatment implications of the altered cytokine-insulin axis in neurodegenerative disease.Biochemical pharmacology, , Oct-01, Volume: 86, Issue:7, 2013
Effects of baseline CSF α-synuclein on regional brain atrophy rates in healthy elders, mild cognitive impairment and Alzheimer's disease.PloS one, , Volume: 8, Issue:12, 2013
Effect of α-synuclein on amyloid β-induced toxicity: relevance to Lewy body variant of Alzheimer disease.Neurochemical research, , Volume: 38, Issue:4, 2013
Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model.Autophagy, , Volume: 9, Issue:4, 2013
Evaluation of potential infectivity of Alzheimer and Parkinson disease proteins in recipients of cadaver-derived human growth hormone.JAMA neurology, , Volume: 70, Issue:4, 2013
Enteric alpha-synuclein expression is increased in Parkinson's disease but not Alzheimer's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:2, 2013
Synthesis of the Alzheimer drug Posiphen into its primary metabolic products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their inhibition of amyloid precursor protein, α-Synuclein synthesis, interleukin-1β release, and cholinergiAnti-inflammatory & anti-allergy agents in medicinal chemistry, , Volume: 12, Issue:2, 2013
Low CSF levels of both α-synuclein and the α-synuclein cleaving enzyme neurosin in patients with synucleinopathy.PloS one, , Volume: 8, Issue:1, 2013
Kinase-kinase interaction and modulation of tau phosphorylation.International review of cell and molecular biology, , Volume: 300, 2013
Naturally occurring α-synuclein autoantibody levels are lower in patients with Parkinson disease.Neurology, , Jan-08, Volume: 80, Issue:2, 2013
Tetrahydroxystilbene glucoside antagonizes age-related α-synuclein overexpression in the hippocampus of APP transgenic mouse model of Alzheimer's disease.Restorative neurology and neuroscience, , Volume: 31, Issue:1, 2013
Personalized medicine strategies for managing patients with parkinsonism and cognitive deficits.Metabolism: clinical and experimental, , Volume: 62 Suppl 1, 2013
Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.Molecular psychiatry, , Volume: 18, Issue:8, 2013
Alzheimer's disease-related lesions.Journal of Alzheimer's disease : JAD, , Volume: 33 Suppl 1, 2013
Neuropathologic analysis of Lewy-related α-synucleinopathy in olfactory mucosa.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 33, Issue:1, 2013
Plasma homocysteine, Alzheimer and cerebrovascular pathology: a population-based autopsy study.Brain : a journal of neurology, , Volume: 136, Issue:Pt 9, 2013
The diagnostic value of CSF α-synuclein in the differential diagnosis of dementia with Lewy bodies vs. normal subjects and patients with Alzheimer's disease.PloS one, , Volume: 8, Issue:11, 2013
Self-propagation of pathogenic protein aggregates in neurodegenerative diseases.Nature, , Sep-05, Volume: 501, Issue:7465, 2013
Impaired mitochondrial energy production and ABC transporter function-A crucial interconnection in dementing proteopathies of the brain.Mechanisms of ageing and development, , Volume: 134, Issue:10, 2013
[The role of extracellular α-synuclein in molecular mechanisms of cell death].Postepy higieny i medycyny doswiadczalnej (Online), , Nov-04, Volume: 67, 2013
Identification of the sites of tau hyperphosphorylation and activation of tau kinases in synucleinopathies and Alzheimer's diseases.PloS one, , Volume: 8, Issue:9, 2013
Early Alzheimer's and Parkinson's disease pathology in urban children: Friend versus Foe responses--it is time to face the evidence.BioMed research international, , Volume: 2013, 2013
[Neurotoxicity of pesticides: its relationship with neurodegenerative diseases].Medecine sciences : M/S, , Volume: 29, Issue:3, 2013
Prolyl oligopeptidase colocalizes with α-synuclein, β-amyloid, tau protein and astroglia in the post-mortem brain samples with Parkinson's and Alzheimer's diseases.Neuroscience, , Jul-09, Volume: 242, 2013
α-Synuclein in cerebrospinal fluid of Alzheimer's disease and mild cognitive impairment.Journal of Alzheimer's disease : JAD, , Volume: 36, Issue:4, 2013
Parkinsonism, dementia and glucocerebrosidase mutations.Journal of neurology, , Volume: 260, Issue:5, 2013
Small molecules interacting with α-synuclein: antiaggregating and cytoprotective properties.Amino acids, , Volume: 45, Issue:2, 2013
Altered serum IgG levels to α-synuclein in dementia with Lewy bodies and Alzheimer's disease.PloS one, , Volume: 8, Issue:5, 2013
CSF levels of the neuronal injury biomarker visinin-like protein-1 in Alzheimer's disease and dementia with Lewy bodies.Journal of neurochemistry, , Volume: 127, Issue:5, 2013
CSF α-synuclein improves diagnostic and prognostic performance of CSF tau and Aβ in Alzheimer's disease.Acta neuropathologica, , Volume: 126, Issue:5, 2013
Experimental inhibition of fibrillogenesis and neurotoxicity by amyloid-beta (Aβ) and other disease-related peptides/proteins by plant extracts and herbal compounds.Sub-cellular biochemistry, , Volume: 65, 2012
Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate.Scientific reports, , Volume: 2, 2012
Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias.Brain : a journal of neurology, , Volume: 135, Issue:Pt 12, 2012
GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology.Neurology, , Nov-06, Volume: 79, Issue:19, 2012
Recommendations to standardize preanalytical confounding factors in Alzheimer's and Parkinson's disease cerebrospinal fluid biomarkers: an update.Biomarkers in medicine, , Volume: 6, Issue:4, 2012
Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research.PloS one, , Volume: 7, Issue:7, 2012
Soluble α-synuclein is a novel modulator of Alzheimer's disease pathophysiology.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jul-25, Volume: 32, Issue:30, 2012
[The role of proteins in neurodegenerative disease].Postepy higieny i medycyny doswiadczalnej (Online), , Apr-16, Volume: 66, 2012
Oxidative stress in Alzheimer's and Parkinson's diseases: insights from the yeast Saccharomyces cerevisiae.Oxidative medicine and cellular longevity, , Volume: 2012, 2012
Selection of DNA aptamers that recognize α-synuclein oligomers using a competitive screening method.Analytical chemistry, , Jul-03, Volume: 84, Issue:13, 2012
[An 87-year-old women with the clinical diagnosis of dementia with Lewy bodies without α-synuclein deposition].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 64, Issue:5, 2012
α-Synuclein mRNA and soluble α-synuclein protein levels in post-mortem brain from patients with Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease.Brain research, , Jun-12, Volume: 1459, 2012
Positive lysosomal modulation as a unique strategy to treat age-related protein accumulation diseases.Rejuvenation research, , Volume: 15, Issue:2, 2012
Generic inhibition of amyloidogenic proteins by two naphthoquinone-tryptophan hybrid molecules.Proteins, , Volume: 80, Issue:8, 2012
A proteomic analysis of MCLR-induced neurotoxicity: implications for Alzheimer's disease.Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 127, Issue:2, 2012
Pathologic evaluation of the supraoptic and paraventricular nuclei in dementia.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, , Volume: 39, Issue:2, 2012
An evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology.Journal of neurology, neurosurgery, and psychiatry, , Volume: 83, Issue:4, 2012
Antibody 9D5 recognizes oligomeric pyroglutamate amyloid-β in a fraction of amyloid-β deposits in Alzheimer's disease without cross-reactivity with other protein aggregates.Journal of Alzheimer's disease : JAD, , Volume: 29, Issue:2, 2012
Altered CSF orexin and α-synuclein levels in dementia patients.Journal of Alzheimer's disease : JAD, , Volume: 29, Issue:1, 2012
Amyloid generation and dysfunctional immunoproteasome activation with disease progression in animal model of familial Alzheimer's disease.Brain pathology (Zurich, Switzerland), , Volume: 22, Issue:5, 2012
Interaction between pathogenic proteins in neurodegenerative disorders.Journal of cellular and molecular medicine, , Volume: 16, Issue:6, 2012
Neuropathological investigation of the hypometabolic regions on positron emission tomography with [18F] fluorodeoxyglucose in patients with dementia with Lewy bodies.Journal of the neurological sciences, , Mar-15, Volume: 314, Issue:1-2, 2012
Parkinson disease: PD biomarkers-use of α-synuclein reaches new levels.Nature reviews. Neurology, , May-10, Volume: 7, Issue:6, 2011
[Role of genetics in the etiology of synucleinopathies].Revista espanola de geriatria y gerontologia, , Volume: 46 Suppl 1, 2011
Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes.Bioorganic & medicinal chemistry, , Dec-15, Volume: 19, Issue:24, 2011
Caenorhabditis elegans as an experimental tool for the study of complex neurological diseases: Parkinson's disease, Alzheimer's disease and autism spectrum disorder.Invertebrate neuroscience : IN, , Volume: 11, Issue:2, 2011
CSF α-synuclein concentrations do not fluctuate over hours and are not correlated to amyloid β in humans.Neuroscience letters, , Oct-31, Volume: 504, Issue:3, 2011
Xanthene food dye, as a modulator of Alzheimer's disease amyloid-beta peptide aggregation and the associated impaired neuronal cell function.PloS one, , Volume: 6, Issue:10, 2011
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein.The Journal of biological chemistry, , Sep-30, Volume: 286, Issue:39, 2011
Toward the discovery of effective polycyclic inhibitors of alpha-synuclein amyloid assembly.The Journal of biological chemistry, , Sep-16, Volume: 286, Issue:37, 2011
Decreased α-synuclein serum levels in patients with Lewy body dementia compared to Alzheimer's disease patients and control subjects.Dementia and geriatric cognitive disorders, , Volume: 31, Issue:6, 2011
Neuropathology underlying clinical variability in patients with synucleinopathies.Acta neuropathologica, , Volume: 122, Issue:2, 2011
α-Synuclein expression selectively affects tumorigenesis in mice modeling Parkinson's disease.PloS one, , Volume: 6, Issue:5, 2011
Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?Brain : a journal of neurology, , Volume: 134, Issue:Pt 5, 2011
Autoantibodies against amyloid and glial-derived antigens are increased in serum and cerebrospinal fluid of Lewy body-associated dementias.Journal of Alzheimer's disease : JAD, , Volume: 26, Issue:1, 2011
A deadly spread: cellular mechanisms of α-synuclein transfer.Cell death and differentiation, , Volume: 18, Issue:9, 2011
Aberrant protein structure and diseases of the brain.Irish journal of medical science, , Volume: 180, Issue:1, 2011
Prevalence and pathology of dementia with Lewy bodies in the oldest old: a comparison with other dementing disorders.Dementia and geriatric cognitive disorders, , Volume: 31, Issue:4, 2011
A novel mechanism of non-Aβ component of Alzheimer's disease amyloid (NAC) neurotoxicity. Interplay between p53 protein and cyclin-dependent kinase 5 (Cdk5).Neurochemistry international, , Volume: 58, Issue:2, 2011
CSF amyloid-β peptides in neuropathologically diagnosed dementia with Lewy bodies and Alzheimer's disease.Journal of Alzheimer's disease : JAD, , Volume: 24, Issue:2, 2011
α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study.The Lancet. Neurology, , Volume: 10, Issue:3, 2011
The n-terminal 5-MER peptide analogue P165 of amyloid precursor protein exerts protective effects on SH-SY5Y cells and rat hippocampus neuronal synapses.Neuroscience, , Jan-26, Volume: 173, 2011
Increased dopaminergic cells and protein aggregates in the olfactory bulb of patients with neurodegenerative disorders.Acta neuropathologica, , Volume: 122, Issue:1, 2011
TAR-DNA binding protein-43 and alterations in the hippocampus.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 118, Issue:5, 2011
Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression.Annals of neurology, , Volume: 69, Issue:3, 2011
Single-molecule atomic force microscopy force spectroscopy study of Aβ-40 interactions.Biochemistry, , Jun-14, Volume: 50, Issue:23, 2011
Distribution of cerebral amyloid deposition and its relevance to clinical phenotype in Lewy body dementia.Neuroscience letters, , Dec-03, Volume: 486, Issue:1, 2010
[GSK-3beta: a central kinase for neurodegenerative diseases?].Medecine sciences : M/S, , Volume: 26, Issue:5, 2010
Neuropathology of dementia with Lewy bodies in advanced age: a comparison with Alzheimer disease.Neuroscience letters, , Nov-26, Volume: 485, Issue:3, 2010
Structure and function of the molecular chaperone Hsp104 from yeast.Biopolymers, , Volume: 93, Issue:3, 2010
[Alpha-synuclein and Alzheimer's disease].Sheng li ke xue jin zhan [Progress in physiology], , Volume: 41, Issue:2, 2010
Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline.The Journal of neuroscience : the official journal of the Society for Neuroscience, , May-26, Volume: 30, Issue:21, 2010
CSF α-synuclein does not discriminate dementia with Lewy bodies from Alzheimer's disease.Journal of Alzheimer's disease : JAD, , Volume: 22, Issue:1, 2010
The Society for Neuroscience 2009 meeting report, part 2.Journal of Alzheimer's disease : JAD, , Volume: 19, Issue:4, 2010
Regulation of Weibel-Palade body exocytosis by alpha-synuclein in endothelial cells.The Journal of biological chemistry, , Jul-09, Volume: 285, Issue:28, 2010
Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease.Neurology, , Nov-16, Volume: 75, Issue:20, 2010
Mitochondrial trafficking of APP and alpha synuclein: Relevance to mitochondrial dysfunction in Alzheimer's and Parkinson's diseases.Biochimica et biophysica acta, , Volume: 1802, Issue:1, 2010
Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease.Annals of neurology, , Volume: 67, Issue:4, 2010
CSF α-synuclein as a diagnostic biomarker for Parkinson disease and related dementias.Neurology, , Nov-16, Volume: 75, Issue:20, 2010
Burden of neurodegenerative diseases in a cohort of medical examiner subjects.Journal of forensic sciences, , Volume: 55, Issue:3, 2010
Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders.Acta neuropathologica, , Volume: 119, Issue:6, 2010
Chaperone-mediated autophagy markers in Parkinson disease brains.Archives of neurology, , Volume: 67, Issue:12, 2010
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-03, Volume: 30, Issue:9, 2010
Abnormal neurites containing C-terminally truncated alpha-synuclein are present in Alzheimer's disease without conventional Lewy body pathology.The American journal of pathology, , Volume: 177, Issue:6, 2010
Evidence in favor of Braak staging of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 25 Suppl 1, 2010
Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy.PloS one, , Feb-19, Volume: 5, Issue:2, 2010
Bis(thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease.Journal of Alzheimer's disease : JAD, , Volume: 20, Issue:1, 2010
DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease.Brain : a journal of neurology, , Volume: 133, Issue:Pt 3, 2010
Tau protein: relevance to Parkinson's disease.The international journal of biochemistry & cell biology, , Volume: 42, Issue:11, 2010
Frontal lobe white matter hyperintensities and neurofibrillary pathology in the oldest old.Neurology, , Dec-07, Volume: 75, Issue:23, 2010
Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jul-07, Volume: 30, Issue:27, 2010
Prediction of pathology in primary progressive language and speech disorders.Neurology, , Jan-05, Volume: 74, Issue:1, 2010
Soluble and mature amyloid fibrils in drusen deposits.Investigative ophthalmology & visual science, , Volume: 51, Issue:3, 2010
Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease.Neuroscience letters, , Aug-09, Volume: 480, Issue:1, 2010
Neuropathological asymmetry in argyrophilic grain disease.Journal of neuropathology and experimental neurology, , Volume: 69, Issue:7, 2010
Recurrent systemic infections with Streptococcus pneumoniae do not aggravate the course of experimental neurodegenerative diseases.Journal of neuroscience research, , Volume: 88, Issue:5, 2010
Differential levels of alpha-synuclein, beta-amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer's disease.Journal of neurology, neurosurgery, and psychiatry, , Volume: 81, Issue:6, 2010
CSF synuclein: adding to the biomarker footprint of dementia with Lewy bodies.Journal of neurology, neurosurgery, and psychiatry, , Volume: 81, Issue:6, 2010
Mechanism of amyloidogenesis: nucleation-dependent fibrillation versus double-concerted fibrillation.BMB reports, , Sep-30, Volume: 42, Issue:9, 2009
Quantitation and mapping of cerebral detergent-insoluble proteins in the elderly.Brain pathology (Zurich, Switzerland), , Volume: 19, Issue:3, 2009
Inhibitors of protein aggregation and toxicity.Biochemical Society transactions, , Volume: 37, Issue:Pt 4, 2009
Trends in the molecular pathogenesis and clinical therapeutics of common neurodegenerative disorders.International journal of molecular sciences, , Jun-03, Volume: 10, Issue:6, 2009
In vitro characterisation of BF227 binding to alpha-synuclein/Lewy bodies.European journal of pharmacology, , Sep-01, Volume: 617, Issue:1-3, 2009
High-resolution temperature-concentration diagram of alpha-synuclein conformation obtained from a single Förster resonance energy transfer image in a microfluidic device.Analytical chemistry, , Aug-15, Volume: 81, Issue:16, 2009
Intrinsic disorder in proteins associated with neurodegenerative diseases.Frontiers in bioscience (Landmark edition), , 06-01, Volume: 14, Issue:14, 2009
Exploiting a (13)C-labelled heparin analogue for in situ solid-state NMR investigations of peptide-glycan interactions within amyloid fibrils.Organic & biomolecular chemistry, , Jun-07, Volume: 7, Issue:11, 2009
Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction.Acta neuropathologica, , Volume: 117, Issue:6, 2009
Heavy alcohol consumption and neuropathological lesions: a post-mortem human study.Journal of neuroscience research, , Volume: 87, Issue:12, 2009
Parkinson's disease dementia and dementia with Lewy bodies: different aspects of one entity.International psychogeriatrics, , Volume: 21, Issue:2, 2009
Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases.Biochimica et biophysica acta, , Volume: 1790, Issue:7, 2009
Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies.Brain : a journal of neurology, , Volume: 132, Issue:Pt 4, 2009
CSF alpha-synuclein levels in dementia with Lewy bodies and Alzheimer's disease.Brain research, , Jan-28, Volume: 1251, 2009
Criteria for the neuropathological diagnosis of dementing disorders: routes out of the swamp?Acta neuropathologica, , Volume: 117, Issue:2, 2009
Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss?Neuroscience letters, , Feb-06, Volume: 450, Issue:3, 2009
Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders.Acta neuropathologica, , Volume: 117, Issue:2, 2009
Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders.Acta neuropathologica, , Volume: 117, Issue:2, 2009
[In-vivo imaging for pursuing molecular cascades in the pathogenesis of neurodegenerative diseases].Rinsho shinkeigaku = Clinical neurology, , Volume: 49, Issue:11, 2009
Lewy body variant of Alzheimer's disease: selective neocortical loss of t-SNARE proteins and loss of MAP2 and alpha-synuclein in medial temporal lobe.TheScientificWorldJournal, , Dec-16, Volume: 9, 2009
Creutzfeldt-jakob, Parkinson, lewy body dementia and Alzheimer diseases: from diagnosis to therapy.Central nervous system agents in medicinal chemistry, , Volume: 9, Issue:1, 2009
[Molecular neuropathology of Non-Alzheimer dementia].Der Pathologe, , Volume: 29, Issue:6, 2008
Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases.PloS one, , Sep-04, Volume: 3, Issue:9, 2008
MRI correlates of neurofibrillary tangle pathology at autopsy: a voxel-based morphometry study.Neurology, , Sep-02, Volume: 71, Issue:10, 2008
Co-localization of tau and alpha-synuclein in the olfactory bulb in Alzheimer's disease with amygdala Lewy bodies.Acta neuropathologica, , Volume: 116, Issue:1, 2008
Olfactory pathogenesis of idiopathic Parkinson disease revisited.Movement disorders : official journal of the Movement Disorder Society, , Jun-15, Volume: 23, Issue:8, 2008
Systematic appraisal using immunohistochemistry of brain pathology in aged and demented subjects.Dementia and geriatric cognitive disorders, , Volume: 25, Issue:5, 2008
Spontaneous aggregation and altered intracellular distribution of endogenous alpha-synuclein during neuronal apoptosis.Journal of Alzheimer's disease : JAD, , Volume: 13, Issue:2, 2008
Patterns and stages of alpha-synucleinopathy: Relevance in a population-based cohort.Neurology, , Mar-25, Volume: 70, Issue:13, 2008
Differences between normal and alpha-synuclein overexpressing SH-SY5Y neuroblastoma cells after Abeta(1-42) and NAC treatment.Brain research bulletin, , Mar-28, Volume: 75, Issue:5, 2008
Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies.Neuroscience, , Apr-09, Volume: 152, Issue:4, 2008
Differential expression of alpha-synuclein, parkin, and synphilin-1 isoforms in Lewy body disease.Neurogenetics, , Volume: 9, Issue:3, 2008
Characterization of fibrillation process of alpha-synuclein at the initial stage.Biochemical and biophysical research communications, , May-09, Volume: 369, Issue:3, 2008
Protein folding diseases and neurodegeneration: lessons learned from yeast.Biochimica et biophysica acta, , Volume: 1783, Issue:7, 2008
A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides.Nature neuroscience, , Volume: 11, Issue:3, 2008
Early discriminatory diagnosis of dementia with Lewy bodies. The emerging role of CSF and imaging biomarkers.Dementia and geriatric cognitive disorders, , Volume: 25, Issue:3, 2008
Noninvasive measurement of protein aggregation by mutant huntingtin fragments or alpha-synuclein in the lens.The Journal of biological chemistry, , Mar-07, Volume: 283, Issue:10, 2008
Commentary to "Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease".Neurochemical research, , Volume: 33, Issue:6, 2008
Identification and characterization of a new alpha-synuclein isoform and its role in Lewy body diseases.Neurogenetics, , Volume: 9, Issue:1, 2008
Evaluation of alpha-synuclein immunohistochemical methods used by invited experts.Acta neuropathologica, , Volume: 116, Issue:3, 2008
[Near a biological diagnosis of Alzheimer's disease and related disorders].La Revue de medecine interne, , Volume: 29, Issue:10, 2008
Alpha- and gamma-synuclein proteins are present in cerebrospinal fluid and are increased in aged subjects with neurodegenerative and vascular changes.Dementia and geriatric cognitive disorders, , Volume: 26, Issue:1, 2008
Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders.Autoimmunity reviews, , Volume: 7, Issue:6, 2008
The alpha-synuclein burden hypothesis of Parkinson disease and its relationship to Alzheimer disease.Experimental neurology, , Volume: 212, Issue:2, 2008
alpha-Synuclein enhances secretion and toxicity of amyloid beta peptides in PC12 cells.Neurochemistry international, , Volume: 53, Issue:6-8, 2008
Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-28, Volume: 27, Issue:48, 2007
Concurrence of TDP-43, tau and alpha-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies.Brain research, , Dec-12, Volume: 1184, 2007
Transgenic animal models of neurodegenerative diseases and their application to treatment development.Advanced drug delivery reviews, , Sep-30, Volume: 59, Issue:11, 2007
Differentiating Alzheimer disease-associated aggregates with small molecules.Neurobiology of disease, , Volume: 28, Issue:3, 2007
[Pathology of familial Parkinson's disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 59, Issue:8, 2007
In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution.Neurology, , Jul-24, Volume: 69, Issue:4, 2007
Nitration in neurodegeneration: deciphering the "Hows" "nYs".Biochemistry, , Jun-26, Volume: 46, Issue:25, 2007
alpha-Synuclein and its disease-related mutants interact differentially with the microtubule protein tau and associate with the actin cytoskeleton.Neurobiology of disease, , Volume: 26, Issue:3, 2007
A variable poly-T sequence modulates alpha-synuclein isoform expression and is associated with aging.Journal of neuroscience research, , May-15, Volume: 85, Issue:7, 2007
Lewy body variant of Alzheimer's disease or cerebral type lewy body disease? Two autopsy cases of presenile onset with minimal involvement of the brainstem.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 27, Issue:1, 2007
Tauopathies and synucleinopathies: do cerebrospinal fluid beta-amyloid peptides reflect disease-specific pathogenesis?Journal of neural transmission (Vienna, Austria : 1996), , Volume: 114, Issue:7, 2007
[Animal models of neurodegenerative diseases].Medecine sciences : M/S, , Volume: 23, Issue:2, 2007
Mutant ubiquitin and p62 immunoreactivity in cases of combined multiple system atrophy and Alzheimer's disease.Acta neuropathologica, , Volume: 113, Issue:4, 2007
Tau and alpha-synuclein brainstem pathology in Alzheimer disease: relation with extrapyramidal signs.Acta neuropathologica, , Volume: 113, Issue:1, 2007
Cerebrospinal fluid of Alzheimer's disease and dementia with Lewy bodies patients enhances alpha-synuclein fibril formation in vitro.Experimental neurology, , Volume: 203, Issue:2, 2007
Identification of G-protein coupled receptor kinase 2 in paired helical filaments and neurofibrillary tangles.Journal of neuropathology and experimental neurology, , Volume: 65, Issue:12, 2006
Natural antisense transcripts of Alzheimer's disease associated genes.DNA sequence : the journal of DNA sequencing and mapping, , Volume: 17, Issue:2, 2006
[Nosology of dementias: the neuropathologist's point of view].Revue neurologique, , Volume: 162, Issue:10, 2006
A spectroscopic study of some of the peptidyl radicals formed following hydroxyl radical attack on beta-amyloid and alpha-synuclein.Free radical research, , Volume: 40, Issue:7, 2006
Small molecule oxidation products trigger disease-associated protein misfolding.Accounts of chemical research, , Volume: 39, Issue:9, 2006
Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease.Experimental & molecular medicine, , Aug-31, Volume: 38, Issue:4, 2006
Low alpha-synuclein 126 mRNA levels in dementia with Lewy bodies and Alzheimer disease.Neuroreport, , Aug-21, Volume: 17, Issue:12, 2006
Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease.Neurochemical research, , Volume: 31, Issue:9, 2006
Lewy body pathology in late-onset familial Alzheimer's disease: a clinicopathological case series.Journal of Alzheimer's disease : JAD, , Volume: 9, Issue:3, 2006
Linker histone H1 binds to disease associated amyloid-like fibrils.Journal of molecular biology, , Aug-18, Volume: 361, Issue:3, 2006
[Amyloid-beta protein vaccine therapy for alzheimer's disease].Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, , Jun-10, Volume: 95, Issue:6, 2006
Alzheimer disease with amygdala Lewy bodies: a distinct form of alpha-synucleinopathy.Journal of neuropathology and experimental neurology, , Volume: 65, Issue:7, 2006
Biochemical staging of synucleinopathy and amyloid deposition in dementia with Lewy bodies.Journal of neuropathology and experimental neurology, , Volume: 65, Issue:3, 2006
[Abeta, tau and alpha-synuclein and glial cells].Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, , Volume: 26, Issue:1, 2006
Lewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotype.Archives of neurology, , Volume: 63, Issue:3, 2006
Relation of quantitative indexes of concurrent alpha-synuclein abnormalities to clinical outcome in autopsy-proven Alzheimer disease.Archives of neurology, , Volume: 63, Issue:2, 2006
The distribution pattern of pathology and cholinergic deficits in amygdaloid complex in Alzheimer's disease and dementia with Lewy bodies.Acta neuropathologica, , Volume: 111, Issue:2, 2006
Nurr1 in Parkinson's disease and related disorders.The Journal of comparative neurology, , Jan-20, Volume: 494, Issue:3, 2006
Novel presenilin 1 mutation (S170F) causing Alzheimer disease with Lewy bodies in the third decade of life.Archives of neurology, , Volume: 62, Issue:12, 2005
New presenilin 1 mutation with Alzheimer disease and Lewy bodies.Archives of neurology, , Volume: 62, Issue:12, 2005
American Chemical Society 230th National Meeting. Neurological disorders.IDrugs : the investigational drugs journal, , Volume: 8, Issue:11, 2005
Metal ions and oxidative protein modification in neurological disease.Annali dell'Istituto superiore di sanita, , Volume: 41, Issue:2, 2005
The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy.British journal of pharmacology, , Volume: 146, Issue:8, 2005
How to diagnose dementia with Lewy bodies: state of the art.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
Engineered alpha-synuclein prevents wild type and familial Parkin variant fibril formation.Biochemical and biophysical research communications, , Sep-23, Volume: 335, Issue:2, 2005
Agrin binds alpha-synuclein and modulates alpha-synuclein fibrillation.Glycobiology, , Volume: 15, Issue:12, 2005
Cognitive differences in dementia patients with autopsy-verified AD, Lewy body pathology, or both.Neurology, , Jun-28, Volume: 64, Issue:12, 2005
In vitro preparation of prefibrillar intermediates of amyloid-beta and alpha-synuclein.Methods in molecular biology (Clifton, N.J.), , Volume: 299, 2005
Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA).Journal of neuropathology and experimental neurology, , Volume: 64, Issue:6, 2005
Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases.The Journal of biological chemistry, , Jul-01, Volume: 280, Issue:26, 2005
The pathology of the substantia nigra in Alzheimer disease with extrapyramidal signs.Neurology, , Apr-26, Volume: 64, Issue:8, 2005
A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease.The Journal of biological chemistry, , Jun-17, Volume: 280, Issue:24, 2005
Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA).Journal of neuropathology and experimental neurology, , Volume: 64, Issue:2, 2005
A mutant PSEN1 causes dementia with Lewy bodies and variant Alzheimer's disease.Annals of neurology, , Volume: 57, Issue:3, 2005
Genetic association between the APOE*4 allele and Lewy bodies in Alzheimer disease.Neurology, , Feb-08, Volume: 64, Issue:3, 2005
Insoluble alpha-synuclein in Alzheimer's disease without Lewy body formation.Neurotoxicity research, , Volume: 7, Issue:1-2, 2005
Differential expression of alpha-synuclein isoforms in dementia with Lewy bodies.Neuropathology and applied neurobiology, , Volume: 30, Issue:6, 2004
Lewy body-related alpha-synucleinopathy in the aged human brain.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 111, Issue:10-11, 2004
ABri peptide associated with familial British dementia forms annular and ring-like protofibrillar structures.Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, , Volume: 11, Issue:1, 2004
Cross-linking of ubiquitin, HSP27, parkin, and alpha-synuclein by gamma-glutamyl-epsilon-lysine bonds in Alzheimer's neurofibrillary tangles.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 18, Issue:10, 2004
Alpha-synuclein, Parkinson's disease, and Alzheimer's disease.Parkinsonism & related disorders, , Volume: 10 Suppl 1, 2004
Dopamine and L-dopa disaggregate amyloid fibrils: implications for Parkinson's and Alzheimer's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 18, Issue:9, 2004
Chasing genes in Alzheimer's and Parkinson's disease.Human genetics, , Volume: 114, Issue:5, 2004
Cycles of aberrant synaptic sprouting and neurodegeneration in Alzheimer's and dementia with Lewy bodies.Neurochemical research, , Volume: 28, Issue:11, 2003
Neuritic alterations and neural system dysfunction in Alzheimer's disease and dementia with Lewy bodies.Neurochemical research, , Volume: 28, Issue:11, 2003
[Lewy bodies, a misleading marker for Parkinson's disease?].Bulletin de l'Academie nationale de medecine, , Volume: 187, Issue:2, 2003
Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer's and Parkinson's diseases.Neuromolecular medicine, , Volume: 4, Issue:1-2, 2003
Tau pathology in the olfactory bulb correlates with Braak stage, Lewy body pathology and apolipoprotein epsilon4.Neuropathology and applied neurobiology, , Volume: 29, Issue:5, 2003
Age-associated prevalence and risk factors of Lewy body pathology in a general population: the Hisayama study.Acta neuropathologica, , Volume: 106, Issue:4, 2003
Dissociation of amyloid fibrils of alpha-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities.Proceedings of the National Academy of Sciences of the United States of America, , Aug-19, Volume: 100, Issue:17, 2003
Toward a molecular neuropsychiatry of neurodegenerative diseases.Annals of neurology, , Volume: 54, Issue:2, 2003
Variability and heterogeneity in Alzheimer's disease with cotton wool plaques: a clinicopathological study of four autopsy cases.Acta neuropathologica, , Volume: 106, Issue:4, 2003
Alpha-synuclein pathology in Parkinson's and Alzheimer's disease brain: incidence and topographic distribution--a pilot study.Acta neuropathologica, , Volume: 106, Issue:3, 2003
Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease.Neuropharmacology, , Volume: 45, Issue:1, 2003
Alpha-synuclein-positive structures in association with diffuse neurofibrillary tangles with calcification.Neuropathology and applied neurobiology, , Volume: 29, Issue:3, 2003
Regional distribution of alpha-synuclein pathology in unimpaired aging and Alzheimer disease.Journal of neuropathology and experimental neurology, , Volume: 62, Issue:4, 2003
Lewy body pathology is a frequent co-pathology in familial Alzheimer's disease.Acta neuropathologica, , Volume: 105, Issue:5, 2003
Ubiquitinated inclusions and neuronal cell death.Histology and histopathology, , Volume: 18, Issue:2, 2003
Recent advances on alpha-synuclein cell biology: functions and dysfunctions.Current molecular medicine, , Volume: 3, Issue:1, 2003
Alpha-synuclein, Abeta and Alzheimer's disease.Progress in neuro-psychopharmacology & biological psychiatry, , Volume: 27, Issue:1, 2003
Nucleus-specific alteration of raphe neurons in human neurodegenerative disorders.Neuroreport, , Jan-20, Volume: 14, Issue:1, 2003
Expression of alpha-synuclein, the precursor of non-amyloid beta component of Alzheimer's disease amyloid, in human cerebral blood vessels.Neuroscience letters, , Jun-21, Volume: 326, Issue:1, 2002
Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease.Free radical biology & medicine, , Jun-01, Volume: 32, Issue:11, 2002
Alzheimer's and Parkinson's disease--overlapping or synergistic pathologies?Trends in molecular medicine, , Volume: 8, Issue:1, 2002
[Gene diagnosis of Alzheimer's disease and Parkinson's disease].Rinsho byori. The Japanese journal of clinical pathology, , Volume: 50, Issue:10, 2002
TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation.Journal of neurochemistry, , Volume: 83, Issue:4, 2002
NACP/alpha-synuclein, NAC, and beta-amyloid pathology of familial Alzheimer's disease with the E184D presenilin-1 mutation: a clinicopathological study of two autopsy cases.Acta neuropathologica, , Volume: 104, Issue:6, 2002
Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease.Pharmacological reviews, , Volume: 54, Issue:3, 2002
Aggregation and neurotoxicity of alpha-synuclein and related peptides.Biochemical Society transactions, , Volume: 30, Issue:4, 2002
Clusterin/apolipoprotein J is associated with cortical Lewy bodies: immunohistochemical study in cases with alpha-synucleinopathies.Acta neuropathologica, , Volume: 104, Issue:3, 2002
Neurodegenerative disease: amyloid pores from pathogenic mutations.Nature, , Jul-18, Volume: 418, Issue:6895, 2002
Production of reactive oxygen species from aggregating proteins implicated in Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases.Current topics in medicinal chemistry, , Volume: 1, Issue:6, 2001
Lewy body pathology in Alzheimer's disease.Journal of molecular neuroscience : MN, , Volume: 17, Issue:2, 2001
Alpha-synuclein in familial Alzheimer disease: epitope mapping parallels dementia with Lewy bodies and Parkinson disease.Archives of neurology, , Volume: 58, Issue:11, 2001
Altered expression of the synuclein family mRNA in Lewy body and Alzheimer's disease.Brain research, , Sep-28, Volume: 914, Issue:1-2, 2001
beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , Oct-09, Volume: 98, Issue:21, 2001
Alpha-synuclein pathology is highly dependent on the case selection.Neuropathology and applied neurobiology, , Volume: 27, Issue:4, 2001
Postnatal expression of alpha-synuclein protein in the rodent substantia nigra and striatum.Developmental neuroscience, , Volume: 23, Issue:2, 2001
Neuropathological correlates to clinically defined dementia with Lewy bodies.International journal of geriatric psychiatry, , Volume: 16, Issue:7, 2001
Identification of the region of non-Abeta component (NAC) of Alzheimer's disease amyloid responsible for its aggregation and toxicity.Journal of neurochemistry, , Volume: 78, Issue:2, 2001
[Alpha-synucleinopathies].Neurologia (Barcelona, Spain), , Volume: 16, Issue:4, 2001
Mouse models of alpha-synucleinopathy and Lewy pathology. Alpha-synuclein expression in transgenic mice.Advances in experimental medicine and biology, , Volume: 487, 2001
beta-amyloid deposits in transgenic mice expressing human beta-amyloid precursor protein have the same characteristics as those in Alzheimer's disease.Neuroscience, , Volume: 104, Issue:2, 2001
Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins.Mechanisms of ageing and development, , Jul-15, Volume: 122, Issue:9, 2001
Alpha-synuclein-positive structures in cases with sporadic Alzheimer's disease: morphology and its relationship to tau aggregation.Brain research, , Jan-12, Volume: 888, Issue:2, 2001
Alpha-synuclein and Parkinson's disease.Cellular and molecular life sciences : CMLS, , Volume: 57, Issue:13-14, 2000
Lewy body variant of Alzheimer's disease: alpha-synuclein in dystrophic neurites of A beta plaques.Neuroreport, , Nov-27, Volume: 11, Issue:17, 2000
Activated microglial cells and complement factors are unrelated to cortical Lewy bodies.Acta neuropathologica, , Volume: 100, Issue:6, 2000
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions.Science (New York, N.Y.), , Nov-03, Volume: 290, Issue:5493, 2000
Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease.Acta neuropathologica, , Volume: 100, Issue:3, 2000
Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease.The American journal of pathology, , Volume: 157, Issue:2, 2000
Late-onset neurodegenerative diseases--the role of protein insolubility.Journal of anatomy, , Volume: 196 ( Pt 4), 2000
Properties of NACP/alpha-synuclein and its role in Alzheimer's disease.Biochimica et biophysica acta, , Jul-26, Volume: 1502, Issue:1, 2000
Alpha-synuclein inclusions in Alzheimer and Lewy body diseases.Journal of neuropathology and experimental neurology, , Volume: 59, Issue:5, 2000
Lewy bodies in Alzheimer's disease: a neuropathological review of 145 cases using alpha-synuclein immunohistochemistry.Brain pathology (Zurich, Switzerland), , Volume: 10, Issue:3, 2000
Accumulation of insoluble alpha-synuclein in dementia with Lewy bodies.Neurobiology of disease, , Volume: 7, Issue:3, 2000
Metal-catalyzed oxidation of alpha-synuclein in the presence of Copper(II) and hydrogen peroxide.Archives of biochemistry and biophysics, , Jun-15, Volume: 378, Issue:2, 2000
Involvement of alpha-synuclein in Parkinson's disease and other neurodegenerative disorders.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 107, Issue:1, 2000
Toxicity of non-abeta component of Alzheimer's disease amyloid, and N-terminal fragments thereof, correlates to formation of beta-sheet structure and fibrils.European journal of biochemistry, , Volume: 267, Issue:8, 2000
Occurrence of human alpha-synuclein immunoreactive neurons with neurofibrillary tangle formation in the limbic areas of patients with Alzheimer's disease.Journal of the neurological sciences, , Mar-15, Volume: 174, Issue:2, 2000
The role of NAC in amyloidogenesis in Alzheimer's disease.The American journal of pathology, , Volume: 156, Issue:2, 2000
Plaque-associated alpha-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor protein.Brain research, , Jan-24, Volume: 853, Issue:2, 2000
Stains for the differential diagnosis of degenerative dementias.Biotechnic & histochemistry : official publication of the Biological Stain Commission, , Volume: 74, Issue:6, 1999
The expression of alpha-, beta-, and gamma-synucleins in olfactory mucosa from patients with and without neurodegenerative diseases.Experimental neurology, , Volume: 160, Issue:2, 1999
Alpha-synuclein in Lewy body disease and Alzheimer's disease.Brain pathology (Zurich, Switzerland), , Volume: 9, Issue:4, 1999
Non-Abeta component of Alzheimer's disease amyloid (NAC) revisited. NAC and alpha-synuclein are not associated with Abeta amyloid.The American journal of pathology, , Volume: 155, Issue:4, 1999
Neural expression profile of alpha-synuclein in developing human cortex.Neuroreport, , Sep-09, Volume: 10, Issue:13, 1999
The genetics of disorders with synuclein pathology and parkinsonism.Human molecular genetics, , Volume: 8, Issue:10, 1999
Alpha-synuclein accumulates in Lewy bodies in Parkinson's disease and dementia with Lewy bodies but not in Alzheimer's disease beta-amyloid plaque cores.Neuroscience letters, , May-14, Volume: 266, Issue:3, 1999
Filamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and alpha-synucleinopathies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences, , Jun-29, Volume: 354, Issue:1386, 1999
Copper(II)-induced self-oligomerization of alpha-synuclein.The Biochemical journal, , Jun-15, Volume: 340 ( Pt 3), 1999
Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro.Neuroreport, , Mar-17, Volume: 10, Issue:4, 1999
Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease.Annals of neurology, , Volume: 45, Issue:3, 1999
Novel alpha-synuclein-immunoreactive proteins in brain samples from the Contursi kindred, Parkinson's, and Alzheimer's disease.Experimental neurology, , Volume: 154, Issue:2, 1998
Alpha synuclein is present in Lewy bodies in sporadic Parkinson's disease.Molecular psychiatry, , Volume: 3, Issue:6, 1998
Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes.The American journal of pathology, , Volume: 153, Issue:5, 1998
Intraneuronal filamentous tau protein and alpha-synuclein deposits in neurodegenerative diseases.Biochemical Society transactions, , Volume: 26, Issue:3, 1998
The synuclein family.Genome research, , Volume: 8, Issue:9, 1998
Mutation in the alpha-synuclein gene and sporadic Parkinson's disease, Alzheimer's disease, and dementia with lewy bodies.Experimental neurology, , Volume: 153, Issue:1, 1998
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alpha-Synuclein--a link between Parkinson and Alzheimer diseases?Nature genetics, , Volume: 16, Issue:4, 1997
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Parkinson's disease: the thalamic components of the limbic loop are severely impaired by alpha-synuclein immunopositive inclusion body pathology.Neurobiology of aging, , Volume: 23, Issue:2
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Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases.Molecular medicine (Cambridge, Mass.), , Volume: 14, Issue:7-8
A statistical and biological approach for identifying misdiagnosis of incipient Alzheimer patients using gene expression data.Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, , Volume: 2006
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Locus Coeruleus Pathology Indicates a Continuum of Lewy Body Dementia.Journal of Parkinson's disease, , Volume: 11, Issue:4
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Default mode network connectivity is linked to cognitive functioning and CSF Aβ1-42 levels in Alzheimer's disease.Archives of gerontology and geriatrics, , Volume: 62
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Development of a new treatment for Alzheimer's disease and Parkinson's disease using anti-aggregatory beta-synuclein-derived peptides.Journal of molecular neuroscience : MN, , Volume: 19, Issue:1-2
Alpha-synuclein in the cerebrospinal fluid differentiates synucleinopathies (Parkinson Disease, dementia with Lewy bodies, multiple system atrophy) from Alzheimer disease.Alzheimer disease and associated disorders, , Volume: 26, Issue:3
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Acupuncture Inhibits the Increase in Alpha-Synuclein by Modulating SGK1 in an MPTP Induced Parkinsonism Mouse Model.The American journal of Chinese medicine, , Volume: 47, Issue:3, 2019
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Squalamine Restores the Function of the Enteric Nervous System in Mouse Models of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 10, Issue:4, 2020
Glial α-synuclein promotes neurodegeneration characterized by a distinct transcriptional program in vivo.Glia, , Volume: 67, Issue:10, 2019
Colonic electrical stimulation improves colonic transit in rotenone-induced Parkinson's disease model through affecting enteric neurons.Life sciences, , Aug-15, Volume: 231, 2019
Impairment of Nrf2- and Nitrergic-Mediated Gastrointestinal Motility in an MPTP Mouse Model of Parkinson's Disease.Digestive diseases and sciences, , Volume: 64, Issue:12, 2019
Is constipation in Parkinson's disease caused by gut or brain pathology?Parkinsonism & related disorders, , Volume: 55, 2018
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Gut dysfunction in Parkinson's disease.World journal of gastroenterology, , Jul-07, Volume: 22, Issue:25, 2016
Hyposmia correlates with SNCA variant and non-motor symptoms in Chinese patients with Parkinson's disease.Parkinsonism & related disorders, , Volume: 21, Issue:6, 2015
Selective expression of α-synuclein-immunoreactivity in vesicular acetylcholine transporter-immunoreactive axons in the guinea pig rectum and human colon.The Journal of comparative neurology, , Feb-15, Volume: 521, Issue:3, 2013
[Pathophysiological process underlying Parkinson's disease: motor & non-motor symptoms].Rinsho shinkeigaku = Clinical neurology, , Volume: 49, Issue:11, 2009
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Abnormal colonic motility in mice overexpressing human wild-type alpha-synuclein.Neuroreport, , May-28, Volume: 19, Issue:8, 2008
Gut dysfunction in Parkinson's disease.World journal of gastroenterology, , Jul-07, Volume: 22, Issue:25, 2016
Alpha-Synuclein Pathology in Sensory Nerve Terminals of the Upper Aerodigestive Tract of Parkinson's Disease Patients.Dysphagia, , Volume: 30, Issue:4, 2015
Apnea and dysphagia as the sole features of an α-synucleinopathy.Neurology, , Nov-18, Volume: 83, Issue:21, 2014
Parkinson disease affects peripheral sensory nerves in the pharynx.Journal of neuropathology and experimental neurology, , Volume: 72, Issue:7, 2013
Low Glucocerebrosidase Activity Predicts Dementia in Parkinson Disease: Less Is Not More!Neurology, , Jan-24, Volume: 100, Issue:4, 2023
Lifelong constipation in Parkinson's disease and other clinically defined alpha-synucleinopathies: A population-based study in Southeast Minnesota.Parkinsonism & related disorders, , Volume: 107, 2023
Investigation of Inflammation in Lewy Body Dementia: A Systematic Scoping Review.International journal of molecular sciences, , Jul-28, Volume: 24, Issue:15, 2023
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Differential immunophenotypes of neuronal cytoplasmic inclusions in the dentate gyrus of multiple system atrophy and their association with clinicopathological features.Journal of neuropathology and experimental neurology, , 03-20, Volume: 82, Issue:4, 2023
Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions.Proceedings of the National Academy of Sciences of the United States of America, , 03-28, Volume: 120, Issue:13, 2023
Beyond Strains: Molecular Diversity in Alpha-Synuclein at the Center of Disease Heterogeneity.International journal of molecular sciences, , Aug-25, Volume: 24, Issue:17, 2023
Liquid-Liquid Phase Separation Promotes Protein Aggregation and Its Implications in Ferroptosis in Parkinson's Disease Dementia.Oxidative medicine and cellular longevity, , Volume: 2022, 2022
Differentiating dementia with Lewy bodies from Alzheimer's disease and Parkinson's disease dementia: an update on imaging modalities.Journal of neurology, , Volume: 269, Issue:2, 2022
Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy.Proceedings of the National Academy of Sciences of the United States of America, , 02-08, Volume: 119, Issue:6, 2022
Structures of α-synuclein filaments from human brains with Lewy pathology.Nature, , Volume: 610, Issue:7933, 2022
Natural speech markers of Alzheimer's disease co-pathology in Lewy body dementias.Parkinsonism & related disorders, , Volume: 102, 2022
The promise of amplification assays for accurate early detection of α-synucleinopathies: A review.Experimental gerontology, , Volume: 165, 2022
Intracellular Accumulation of α-Synuclein Aggregates Promotes S-Nitrosylation of MAP1A Leading to Decreased NMDAR-Evoked Calcium Influx and Loss of Mature Synaptic Spines.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 12-14, Volume: 42, Issue:50, 2022
Nasal Rifampicin Improves Cognition in a Mouse Model of Dementia with Lewy Bodies by Reducing α-Synuclein Oligomers.International journal of molecular sciences, , Aug-06, Volume: 22, Issue:16, 2021
Expression Levels of an Alpha-Synuclein Transcript in Blood May Distinguish between Early Dementia with Lewy Bodies and Parkinson's Disease.International journal of molecular sciences, , Jan-13, Volume: 22, Issue:2, 2021
Therapeutic potential of hesperidin in Parkinson's disease with dementia: inhibition of alpha synuclein and amyloid beta in Drosophila melanogaster.Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, , Jun-30, Volume: 36, Issue:1, 2021
Molecular Factors Mediating Neural Cell Plasticity Changes in Dementia Brain Diseases.Neural plasticity, , Volume: 2021, 2021
PIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia.Molecular psychiatry, , Volume: 26, Issue:10, 2021
Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model.Molecular neurodegeneration, , 09-09, Volume: 16, Issue:1, 2021
Clinicopathological investigation of the background of cognitive decline in elderly schizophrenia.Acta neuropsychiatrica, , Volume: 33, Issue:2, 2021
The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson's disease, multiple system atrophy and dementia with Lewy bodies.Acta neuropathologica, , Volume: 139, Issue:6, 2020
Integrated Plasma and Neuroimaging Biomarkers Associated with Motor and Cognition Severity in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 10, Issue:1, 2020
Hippocampal α-synuclein pathology correlates with memory impairment in multiple system atrophy.Brain : a journal of neurology, , 06-01, Volume: 143, Issue:6, 2020
Cerebrospinal fluid α-synuclein predicts neurodegeneration and clinical progression in non-demented elders.Translational neurodegeneration, , 11-23, Volume: 9, Issue:1, 2020
Effect of Times to Blood Processing on the Stability of Blood Proteins Associated with Dementia.Dementia and geriatric cognitive disorders, , Volume: 49, Issue:3, 2020
Small vessel disease pathological changes in neurodegenerative and vascular dementias concomitant with autonomic dysfunction.Brain pathology (Zurich, Switzerland), , Volume: 30, Issue:1, 2020
DNA methylation analysis of candidate genes associated with dementia in peripheral blood.Epigenomics, , Volume: 12, Issue:23, 2020
Spearmint Extract Containing Rosmarinic Acid Suppresses Amyloid Fibril Formation of Proteins Associated with Dementia.Nutrients, , Nov-13, Volume: 12, Issue:11, 2020
Fluid-based proteomics targeted on pathophysiological processes and pathologies in neurodegenerative diseases.Journal of neurochemistry, , Volume: 151, Issue:4, 2019
Erythrocytes as Biomarkers for Dementia: Analysis of Protein Content and Alpha-Synuclein.Journal of Alzheimer's disease : JAD, , 08-12, Volume: 71, Issue:2, 2019
Targeting alpha synuclein and amyloid beta by a multifunctional, brain-penetrant dopamine D2/D3 agonist D-520: Potential therapeutic application in Parkinson's disease with dementia.Scientific reports, , 12-23, Volume: 9, Issue:1, 2019
The Role of NOX4 in Parkinson's Disease with Dementia.International journal of molecular sciences, , Feb-06, Volume: 20, Issue:3, 2019
Degeneration of dopaminergic circuitry influences depressive symptoms in Lewy body disorders.Brain pathology (Zurich, Switzerland), , Volume: 29, Issue:4, 2019
Clinical and neuropathological differences between Parkinson's disease, Parkinson's disease dementia and dementia with Lewy bodies - current issues and future directions.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Extracellular vesicles, new actors in the search for biomarkers of dementias.Neurobiology of aging, , Volume: 74, 2019
Arylsulfatase A, a genetic modifier of Parkinson's disease, is an α-synuclein chaperone.Brain : a journal of neurology, , 09-01, Volume: 142, Issue:9, 2019
Relationship Between Tau, β Amyloid and α-Synuclein Pathologies.Advances in experimental medicine and biology, , Volume: 1184, 2019
Intriguing Mixed Pathologic Features in a Case of Dementia With Lewy Bodies.The Journal of the American Osteopathic Association, , Sep-01, Volume: 119, Issue:9, 2019
Association between physical activity and dementia's risk factors in patients with Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 126, Issue:3, 2019
Alpha-synuclein gene polymorphism affects risk of dementia in Han Chinese with Parkinson's disease.Neuroscience letters, , 07-27, Volume: 706, 2019
TIGAR inclusion pathology is specific for Lewy body diseases.Brain research, , 03-01, Volume: 1706, 2019
When Do α-Synucleinopathies Start? An Epidemiological Timeline: A Review.JAMA neurology, , 04-01, Volume: 75, Issue:4, 2018
A novel link between trafficking and Lewy body disorders.The Lancet. Neurology, , Volume: 17, Issue:7, 2018
[Multi-Organ Distribution of Alpha-Synuclein Pathology in Dementia with Lewy Bodies].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 70, Issue:5, 2018
Reader response: A new potential biomarker for dementia with Lewy bodies: Skin nerve α-synuclein deposits.Neurology, , 03-13, Volume: 90, Issue:11, 2018
Author response: A new potential biomarker for dementia with Lewy bodies: Skin nerve α-synuclein deposits.Neurology, , 03-13, Volume: 90, Issue:11, 2018
[Autonomic Dysfunction and Skin Biopsy in Dementia with Lewy Bodies].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 70, Issue:8, 2018
The different faces of the p. A53T alpha-synuclein mutation: A screening of Greek patients with parkinsonism and/or dementia.Neuroscience letters, , 04-13, Volume: 672, 2018
Brains with sporadic Creutzfeldt-Jakob disease and copathology showed a prolonged end-stage of disease.Journal of clinical pathology, , Volume: 71, Issue:5, 2018
Mitochondrial activity in the frontal cortex area 8 and angular gyrus in Parkinson's disease and Parkinson's disease with dementia.Brain pathology (Zurich, Switzerland), , Volume: 28, Issue:1, 2018
Ceftriaxone Treatment for Neuronal Deficits: A Histological and MEMRI Study in a Rat Model of Dementia with Lewy Bodies.Behavioural neurology, , Volume: 2018, 2018
Perirhinal accumulation of neuronal alpha-synuclein in a multiple system atrophy patient with dementia.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 37, Issue:5, 2017
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Plasma α-synuclein predicts cognitive decline in Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry, , Volume: 88, Issue:10, 2017
Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy.Neurobiology of disease, , Volume: 104, 2017
Parkinson's Disease: Basic Pathomechanisms and a Clinical Overview.Advances in neurobiology, , Volume: 15, 2017
The Medicinal Chemistry of Natural and Semisynthetic Compounds against Parkinson's and Huntington's Diseases.ACS chemical neuroscience, , 11-15, Volume: 8, Issue:11, 2017
Novel evidence associates higher plasma α-synuclein levels and cognitive impairment in Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry, , Volume: 88, Issue:10, 2017
Profile of cognitive impairment and underlying pathology in multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:3, 2017
Mixed pathologies including chronic traumatic encephalopathy account for dementia in retired association football (soccer) players.Acta neuropathologica, , Volume: 133, Issue:3, 2017
Survival and Causes of Death Among People With Clinically Diagnosed Synucleinopathies With Parkinsonism: A Population-Based Study.JAMA neurology, , 07-01, Volume: 74, Issue:7, 2017
Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis.The Lancet. Neurology, , Volume: 16, Issue:1, 2017
A unique glycan-isoform of transferrin in cerebrospinal fluid: A potential diagnostic marker for neurological diseases.Biochimica et biophysica acta. General subjects, , Volume: 1861, Issue:10, 2017
Decreased Levels of VAMP2 and Monomeric Alpha-Synuclein Correlate with Duration of Dementia.Journal of Alzheimer's disease : JAD, , Volume: 50, Issue:1, 2016
α-synuclein genetic variability: A biomarker for dementia in Parkinson disease.Annals of neurology, , Volume: 79, Issue:6, 2016
Naturally Occurring Autoantibodies against Tau Protein Are Reduced in Parkinson's Disease Dementia.PloS one, , Volume: 11, Issue:11, 2016
Motor and Nonmotor Features of Carriers of the p.A53T Alpha-Synuclein Mutation: A Longitudinal Study.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:8, 2016
Subcortical matter in the α-synucleinopathies spectrum: an MRI pilot study.Journal of neurology, , Volume: 263, Issue:8, 2016
Therapeutic approaches in Parkinson's disease and related disorders.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
ɑ-Synuclein strains and the variable pathologies of synucleinopathies.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Development of an ultra-high sensitive immunoassay with plasma biomarker for differentiating Parkinson disease dementia from Parkinson disease using antibody functionalized magnetic nanoparticles.Journal of nanobiotechnology, , Jun-08, Volume: 14, Issue:1, 2016
White matter hyperintensities, cerebrospinal amyloid-β and dementia in Parkinson's disease.Journal of the neurological sciences, , Aug-15, Volume: 367, 2016
Selective loss of glucocerebrosidase activity in sporadic Parkinson's disease and dementia with Lewy bodies.Molecular neurodegeneration, , Mar-27, Volume: 10, 2015
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The use of cerebrospinal fluid and neuropathologic studies in neuropsychiatry practice and research.The Psychiatric clinics of North America, , Volume: 38, Issue:2, 2015
Curcumin Treatment Improves Motor Behavior in α-Synuclein Transgenic Mice.PloS one, , Volume: 10, Issue:6, 2015
Transgenic rodent models to study alpha-synuclein pathogenesis, with a focus on cognitive deficits.Current topics in behavioral neurosciences, , Volume: 22, 2015
Correlates of cerebrospinal fluid levels of oligomeric- and total-α-synuclein in premotor, motor and dementia stages of Parkinson's disease.Journal of neurology, , Volume: 262, Issue:2, 2015
Medial temporal regional argyrophilic grain as a possible important factor affecting dementia in Parkinson's disease.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 35, Issue:5, 2015
Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation.Molecular neurodegeneration, , Aug-27, Volume: 10, 2015
Neuropathologically mixed Alzheimer's and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes.Acta neuropathologica, , Volume: 129, Issue:5, 2015
The significance of α-synuclein, amyloid-β and tau pathologies in Parkinson's disease progression and related dementia.Neuro-degenerative diseases, , Volume: 13, Issue:2-3, 2014
Clinical and neuroimaging features of patient with early-onset Parkinson's disease with dementia carrying SNCA p.G51D mutation.Parkinsonism & related disorders, , Volume: 20, Issue:2, 2014
A quantitative study of α-synuclein pathology in fifteen cases of dementia associated with Parkinson disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 121, Issue:2, 2014
[Pathogenetic mechanisms of dementia in the older patients with Parkinson's diseases].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, , Volume: 114, Issue:7, 2014
SMG1 identified as a regulator of Parkinson's disease-associated alpha-synuclein through siRNA screening.PloS one, , Volume: 8, Issue:10, 2013
Identification of the sites of tau hyperphosphorylation and activation of tau kinases in synucleinopathies and Alzheimer's diseases.PloS one, , Volume: 8, Issue:9, 2013
Dysfunction of the locus coeruleus-norepinephrine system and related circuitry in Parkinson's disease-related dementia.Journal of neurology, neurosurgery, and psychiatry, , Volume: 84, Issue:7, 2013
Positive lysosomal modulation as a unique strategy to treat age-related protein accumulation diseases.Rejuvenation research, , Volume: 15, Issue:2, 2012
Biomarkers in Parkinson's disease: an update.Current opinion in neurology, , Volume: 25, Issue:4, 2012
Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias.Brain : a journal of neurology, , Volume: 135, Issue:Pt 12, 2012
Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.Autophagy, , May-01, Volume: 8, Issue:5, 2012
[The Parkinson puzzle].Orvosi hetilap, , Dec-30, Volume: 153, Issue:52, 2012
α-Synuclein pathology in the amyotrophic lateral sclerosis/parkinsonism dementia complex in the Kii Peninsula, Japan.Journal of neuropathology and experimental neurology, , Volume: 71, Issue:7, 2012
Pathobiochemical effect of acylated steryl-β-glucoside on aggregation and cytotoxicity of α-synuclein.Neurochemical research, , Volume: 37, Issue:6, 2012
Pathologic accumulation of α-synuclein and Aβ in Parkinson disease patients with dementia.Archives of neurology, , Volume: 69, Issue:10, 2012
Altered CSF orexin and α-synuclein levels in dementia patients.Journal of Alzheimer's disease : JAD, , Volume: 29, Issue:1, 2012
Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders.Archives of neurology, , Volume: 69, Issue:11, 2012
Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H β-synuclein.Molecular brain, , Sep-26, Volume: 5, 2012
Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 22, Issue:1, 2012
Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-21, Volume: 32, Issue:12, 2012
Incidental Lewy body disease: do some cases represent a preclinical stage of dementia with Lewy bodies?Neurobiology of aging, , Volume: 32, Issue:5, 2011
Parkinson's disease with dementia, lewy-body disorders and alpha-synuclein: recent advances and a case report.Acta neurologica Taiwanica, , Volume: 20, Issue:1, 2011
Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?Brain : a journal of neurology, , Volume: 134, Issue:Pt 5, 2011
[108th Scientific Meeting of the Japanese Society of Internal Medicine: symposium: 1. Progress in dementia research--dementia disorders and protein; (3) alpha-synuclein, alpha-synucleinopathies, and dementia].Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, , Sep-10, Volume: 100, Issue:9, 2011
Prevalence and pathology of dementia with Lewy bodies in the oldest old: a comparison with other dementing disorders.Dementia and geriatric cognitive disorders, , Volume: 31, Issue:4, 2011
Epidemiological neuropathology: the MRC Cognitive Function and Aging Study experience.Journal of Alzheimer's disease : JAD, , Volume: 25, Issue:2, 2011
Alpha- and beta-synuclein expression in Parkinson disease with and without dementia.Journal of the neurological sciences, , Nov-15, Volume: 310, Issue:1-2, 2011
Cerebrospinal fluid Tau/α-synuclein ratio in Parkinson's disease and degenerative dementias.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:8, 2011
Protein coding of neurodegenerative dementias: the neuropathological basis of biomarker diagnostics.Acta neuropathologica, , Volume: 119, Issue:4, 2010
Are genetic and sporadic Parkinson's disease patients equally susceptible to develop dementia?Journal of the neurological sciences, , Feb-15, Volume: 289, Issue:1-2, 2010
85-year old man with Parkinson's disease accompanying dementia.Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 62, Issue:6, 2010
Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia.Experimental neurology, , Volume: 225, Issue:1, 2010
Neuropathological asymmetry in argyrophilic grain disease.Journal of neuropathology and experimental neurology, , Volume: 69, Issue:7, 2010
CSF α-synuclein as a diagnostic biomarker for Parkinson disease and related dementias.Neurology, , Nov-16, Volume: 75, Issue:20, 2010
In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia.Neurology, , Jan-05, Volume: 74, Issue:1, 2010
Neurodegenerative dementia and parkinsonism.The journal of nutrition, health & aging, , Volume: 14, Issue:1, 2010
Biomarkers: Parkinson disease with dementia and dementia with Lewy bodies.Parkinsonism & related disorders, , Volume: 16, Issue:5, 2010
The progression of pathology in Parkinson's disease.Annals of the New York Academy of Sciences, , Volume: 1184, 2010
Cellular glutathione peroxidase in human brain: cellular distribution, and its potential role in the degradation of Lewy bodies in Parkinson's disease and dementia with Lewy bodies.Acta neuropathologica, , Volume: 117, Issue:1, 2009
Parkinson's disease dementia and dementia with Lewy bodies: different aspects of one entity.International psychogeriatrics, , Volume: 21, Issue:2, 2009
Criteria for the neuropathological diagnosis of dementing disorders: routes out of the swamp?Acta neuropathologica, , Volume: 117, Issue:2, 2009
The morbid anatomy of dementia in Parkinson's disease.Acta neuropathologica, , Volume: 118, Issue:5, 2009
The paradoxical cell biology of alpha-Synucle.Results and problems in cell differentiation, , Volume: 48, 2009
Heavy alcohol consumption and neuropathological lesions: a post-mortem human study.Journal of neuroscience research, , Volume: 87, Issue:12, 2009
Neuropathology of non-motor features of Parkinson disease.Parkinsonism & related disorders, , Volume: 15 Suppl 3, 2009
Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein.Current protein & peptide science, , Volume: 10, Issue:5, 2009
The ALS/PDC syndrome of Guam and the cycad hypothesis.Neurology, , Feb-03, Volume: 72, Issue:5, 2009
Dementia and visual hallucinations associated with limbic pathology in Parkinson's disease.Parkinsonism & related disorders, , Volume: 15, Issue:3, 2009
Intralaminar nuclei of the thalamus in Lewy body diseases.Brain research bulletin, , Feb-16, Volume: 78, Issue:2-3, 2009
Alpha-synuclein multiplications with parkinsonism, dementia or progressive myoclonus?Parkinsonism & related disorders, , Volume: 15, Issue:5, 2009
Striatal beta-amyloid deposition in Parkinson disease with dementia.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:2, 2008
Clinicopathologic study of a SNCA gene duplication patient with Parkinson disease and dementia.Neurology, , Jan-15, Volume: 70, Issue:3, 2008
Mutation analyses in amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula, Japan.Movement disorders : official journal of the Movement Disorder Society, , Dec-15, Volume: 23, Issue:16, 2008
Autonomic dysfunction in RBD--what can it teach us about disease progression?Sleep medicine, , Volume: 9, Issue:5, 2008
Striatal beta-amyloid deposition in Parkinson disease with dementia.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:5, 2008
Mutations in progranulin gene: clinical, pathological, and ribonucleic acid expression findings.Biological psychiatry, , May-15, Volume: 63, Issue:10, 2008
Enduring involvement of tau, beta-amyloid, alpha-synuclein, ubiquitin and TDP-43 pathology in the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam (ALS/PDC).Acta neuropathologica, , Volume: 116, Issue:6, 2008
Alpha-synuclein assembly as a therapeutic target of Parkinson's disease and related disorders.Current pharmaceutical design, , Volume: 14, Issue:30, 2008
Alpha-synuclein promoter haplotypes and dementia in Parkinson's disease.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, , Apr-05, Volume: 147, Issue:3, 2008
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Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2.The FEBS journal, , Volume: 275, Issue:23, 2008
Applicability of current staging/categorization of alpha-synuclein pathology and their clinical relevance.Acta neuropathologica, , Volume: 115, Issue:4, 2008
Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease.Annals of neurology, , Volume: 62, Issue:2, 2007
[Animal models of neurodegenerative diseases].Medecine sciences : M/S, , Volume: 23, Issue:2, 2007
The ups and downs of alpha-synuclein mRNA expression.Movement disorders : official journal of the Movement Disorder Society, , Jan-15, Volume: 22, Issue:2, 2007
Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication.Neurology, , Mar-20, Volume: 68, Issue:12, 2007
Alpha-synuclein pathology in the olfactory pathways of dementia patients.Journal of anatomy, , Volume: 211, Issue:1, 2007
Lewy body variant of Alzheimer's disease or cerebral type lewy body disease? Two autopsy cases of presenile onset with minimal involvement of the brainstem.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 27, Issue:1, 2007
Neuropathology of Parkinson's disease dementia and dementia with Lewy bodies with reference to striatal pathology.Parkinsonism & related disorders, , Volume: 13 Suppl 3, 2007
Beta-amlyoid 1-42 and tau-protein in cerebrospinal fluid of patients with Parkinson's disease dementia.Dementia and geriatric cognitive disorders, , Volume: 22, Issue:3, 2006
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Characterization of tau pathologies in gray and white matter of Guam parkinsonism-dementia complex.Acta neuropathologica, , Volume: 111, Issue:5, 2006
Characterization of ubiquitinated intraneuronal inclusions in a novel Belgian frontotemporal lobar degeneration family.Journal of neuropathology and experimental neurology, , Volume: 65, Issue:3, 2006
Tau and alpha-synuclein inclusions in a case of familial frontotemporal dementia and progressive aphasia.Journal of neuropathology and experimental neurology, , Volume: 64, Issue:3, 2005
p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies.The Journal of biological chemistry, , Feb-18, Volume: 280, Issue:7, 2005
Alpha-synuclein pathology does not predict extrapyramidal symptoms or dementia.Annals of neurology, , Volume: 57, Issue:1, 2005
No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found.Neuroscience letters, , Jun-10, Volume: 363, Issue:2, 2004
Alpha-synuclein: normal function and role in neurodegenerative diseases.Current topics in developmental biology, , Volume: 60, 2004
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17q-linked frontotemporal dementia-amyotrophic lateral sclerosis without tau mutations with tau and alpha-synuclein inclusions.Archives of neurology, , Volume: 61, Issue:3, 2004
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Limbic neuropathology in idiopathic Parkinson's disease with concomitant dementia.Folia neuropathologica, , Volume: 42, Issue:3, 2004
Pathological involvement of the motor neuron system and hippocampal formation in motor neuron disease-inclusion dementia.Acta neuropathologica, , Volume: 106, Issue:1, 2003
Accumulation of phosphorylated alpha-synuclein in aging human brain.Journal of neuropathology and experimental neurology, , Volume: 62, Issue:6, 2003
Tissue transglutaminase-induced aggregation of alpha-synuclein: Implications for Lewy body formation in Parkinson's disease and dementia with Lewy bodies.Proceedings of the National Academy of Sciences of the United States of America, , Feb-18, Volume: 100, Issue:4, 2003
Familial and sporadic Parkinson's disease usually display the same clinical features.Parkinsonism & related disorders, , Volume: 9, Issue:4, 2003
Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism.Neurology, , Jul-08, Volume: 61, Issue:1, 2003
NACP/alpha-synuclein immunoreactivity in diffuse neurofibrillary tangles with calcification (DNTC).Acta neuropathologica, , Volume: 104, Issue:4, 2002
Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam.The American journal of pathology, , Volume: 160, Issue:5, 2002
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Accumulation of human alpha-synuclein in different cytoskeletons in Lewy bodies in brains of dementia with Lewy bodies.Neuroscience letters, , Aug-18, Volume: 290, Issue:1, 2000
Alpha-synuclein inclusions in amygdala in the brains of patients with the parkinsonism-dementia complex of Guam.Journal of neuropathology and experimental neurology, , Volume: 59, Issue:7, 2000
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Stains for the differential diagnosis of degenerative dementias.Biotechnic & histochemistry : official publication of the Biological Stain Commission, , Volume: 74, Issue:6, 1999
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Curcumin-loaded human endometrial stem cells derived exosomes as an effective carrier to suppress alpha-synuclein aggregates in 6OHDA-induced Parkinson's disease mouse model.Cell and tissue banking, , Volume: 24, Issue:1, 2023
α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 02-08, Volume: 43, Issue:6, 2023
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Distinct effects of SDC3 and FGFRL1 on selective neurodegeneration in AD and PD.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 37, Issue:2, 2023
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Potential Therapeutic Effects of Policosanol from Insect Wax on Caenorhabditis elegans Models of Parkinson's Disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 18, Issue:1-2, 2023
The c-Abl inhibitor IkT-148009 suppresses neurodegeneration in mouse models of heritable and sporadic Parkinson's disease.Science translational medicine, , 01-18, Volume: 15, Issue:679, 2023
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Neuroinflammation, immune response and α-synuclein pathology: how animal models are helping us to connect dots.Expert opinion on drug discovery, , Volume: 18, Issue:1, 2023
A Mouse Model to Test Novel Therapeutics for Parkinson's Disease: an Update on the Thy1-aSyn ("line 61") Mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 20, Issue:1, 2023
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α-Synuclein induces prodromal symptoms of Parkinson's disease via activating TLR2/MyD88/NF-κB pathway in Schwann cells of vagus nerve in a rat model.Journal of neuroinflammation, , Feb-14, Volume: 20, Issue:1, 2023
Selecting the Best Animal Model of Parkinson's Disease for Your Research Purpose: Insight from Current neuropharmacology, , Volume: 21, Issue:5, 2023
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Integrin Mac1 mediates paraquat and maneb-induced learning and memory impairments in mice through NADPH oxidase-NLRP3 inflammasome axis-dependent microglial activation.Journal of neuroinflammation, , Feb-18, Volume: 20, Issue:1, 2023
Mesenchymal stem-cell-derived microvesicles ameliorate MPTP-induced neurotoxicity in mice: a role of the gut-microbiota-brain axis.Psychopharmacology, , Volume: 240, Issue:5, 2023
Rose essential oil diminishes dopaminergic neuron degenerations and reduces α-synuclein aggregation in Caenorhabditis elegans models of Parkinson's disease.Phytotherapy research : PTR, , Volume: 37, Issue:7, 2023
Suppression of neuroinflammation and α-synuclein oligomerization by rotarod walking exercise in subacute MPTP model of Parkinson's disease.Neurochemistry international, , Volume: 165, 2023
Inflammasome inhibition protects dopaminergic neurons from α-synuclein pathology in a model of progressive Parkinson's disease.Journal of neuroinflammation, , Mar-21, Volume: 20, Issue:1, 2023
Pathological α-synuclein accumulation, CSF metabolites changes and brain microstructures in cynomolgus monkeys treated with 6-hydroxydopamine.Neurotoxicology, , Volume: 94, 2023
Cannabidiol Recovers Dopaminergic Neuronal Damage Induced by Reserpine or α-synuclein in Caenorhabditis elegans.Neurochemical research, , Volume: 48, Issue:8, 2023
Vinpocetine prevents rotenone-induced Parkinson disease motor and non-motor symptoms through attenuation of oxidative stress, neuroinflammation and α-synuclein expressions in rats.Neurotoxicology, , Volume: 96, 2023
Biochemical study of the effect of mesenchymal stem cells-derived exosome versus L-Dopa in experimentally induced Parkinson's disease in rats.Molecular and cellular biochemistry, , Volume: 478, Issue:12, 2023
Repositioning doxycycline for treating synucleinopathies: Evidence from a pre-clinical mouse model.Parkinsonism & related disorders, , Volume: 106, 2023
Double-Edged Effects of Venglustat on Behavior and Pathology in Mice Overexpressing α-Synuclein.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:6, 2023
Novel FABP3 ligand, HY-11-9, ameliorates neuropathological deficits in MPTP-induced Parkinsonism in mice.Journal of pharmacological sciences, , Volume: 152, Issue:1, 2023
GRK2-Targeted Knockdown as Therapy for Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:7, 2023
Involvement of Abnormal p-α-syn Accumulation and TLR2-Mediated Inflammation of Schwann Cells in Enteric Autonomic Nerve Dysfunction of Parkinson's Disease: an Animal Model Study.Molecular neurobiology, , Volume: 60, Issue:8, 2023
Advances in understanding the function of alpha-synuclein: implications for Parkinson's disease.Brain : a journal of neurology, , 09-01, Volume: 146, Issue:9, 2023
Asymmetric Presynaptic Depletion of Dopamine Neurons in a International journal of molecular sciences, , May-11, Volume: 24, Issue:10, 2023
Parkinson's Disease: Exploring Different Animal Model Systems.International journal of molecular sciences, , May-22, Volume: 24, Issue:10, 2023
Necrosulfonamide exerts neuroprotective effect by inhibiting necroptosis, neuroinflammation, and α-synuclein oligomerization in a subacute MPTP mouse model of Parkinson's disease.Scientific reports, , 05-31, Volume: 13, Issue:1, 2023
Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy models.Translational neurodegeneration, , 06-13, Volume: 12, Issue:1, 2023
Pharmacologic inhibition of NLRP3 reduces the levels of α-synuclein and protects dopaminergic neurons in a model of Parkinson's disease.Journal of neuroinflammation, , Jun-22, Volume: 20, Issue:1, 2023
Neuroprotective potential of plant derived parenchymal stem cells extract on environmental and genetic models of Parkinson disease through attenuation of oxidative stress and neuroinflammation.Metabolic brain disease, , Volume: 38, Issue:2, 2023
SYNJ1 rescues motor functions in hereditary and sporadic Parkinson's disease mice by upregulating TSP-1 expression.Behavioural brain research, , 08-24, Volume: 452, 2023
The Expression of Parthanatos Markers and miR-7 Mimic Protects Photoreceptors from Parthanatos by Repressing α-Synuclein in Retinal Detachment.The American journal of pathology, , Volume: 193, Issue:11, 2023
Association Between Decreased Srpk3 Expression and Increased Substantia Nigra Alpha-Synuclein Level in an MPTP-Induced Parkinson's Disease Mouse Model.Molecular neurobiology, , Volume: 60, Issue:2, 2023
Hippocampal Reduction of α-Synuclein via RNA Interference Improves Neuropathology in Alzheimer's Disease Mice.Journal of Alzheimer's disease : JAD, , Volume: 95, Issue:1, 2023
The Involvement of Progranulin for α-Synuclein Reduction through Autolysosome Formation.Biological & pharmaceutical bulletin, , Volume: 46, Issue:8, 2023
Neuroprotective effects of osmotin in Parkinson's disease-associated pathology via the AdipoR1/MAPK/AMPK/mTOR signaling pathways.Journal of biomedical science, , Aug-11, Volume: 30, Issue:1, 2023
Novel naturally occurring autoantibodies attenuate α-synuclein pathology in a mouse model of Parkinson's disease.Neuropathology and applied neurobiology, , Volume: 49, Issue:1, 2023
CHCHD2 p.Thr61Ile knock-in mice exhibit motor defects and neuropathological features of Parkinson's disease.Brain pathology (Zurich, Switzerland), , Volume: 33, Issue:3, 2023
Effects of ozone treatment to the levels of neurodegeneration biomarkers after rotenone induced rat model of Parkinson's disease.Neuroscience letters, , 09-25, Volume: 814, 2023
Aggregation-Inhibiting scFv-Based Therapies Protect Mice against AAV1/2-Induced A53T-α-Synuclein Overexpression.Biomolecules, , 07-31, Volume: 13, Issue:8, 2023
Association between SGK1 and α-synuclein in skeletal muscle in an MPTP-induced Parkinson's disease model.Neuroscience letters, , 09-25, Volume: 814, 2023
Distinct Patterns of Gene Expression Changes in the Colon and Striatum of Young Mice Overexpressing Alpha-Synuclein Support Parkinson's Disease as a Multi-System Process.Journal of Parkinson's disease, , Volume: 13, Issue:7, 2023
PET imaging in animal models of Parkinson's disease.Behavioural brain research, , 02-13, Volume: 438, 2023
Novel systemic delivery of a peptide-conjugated antisense oligonucleotide to reduce α-synuclein in a mouse model of Alzheimer's disease.Neurobiology of disease, , 10-01, Volume: 186, 2023
A Novel NOX Inhibitor Alleviates Parkinson's Disease Pathology in PFF-Injected Mice.International journal of molecular sciences, , Sep-19, Volume: 24, Issue:18, 2023
Measuring Constipation in a Drosophila Model of Parkinson's Disease.Journal of visualized experiments : JoVE, , 09-22, Issue:199, 2023
Alpha-Synuclein-Specific Regulatory T Cells Ameliorate Parkinson's Disease Progression in Mice.International journal of molecular sciences, , Oct-16, Volume: 24, Issue:20, 2023
Antagonizing pathological α-synuclein-mediated neurodegeneration by J24335 via the activation of immunoproteasome.Toxicology and applied pharmacology, , Dec-01, Volume: 480, 2023
Anethole attenuates motor dysfunctions, striatal neuronal activity deficiency and blood brain barrier permeability by decreasing striatal α-synuclein and oxidative stress in rotenone-induced Parkinson's disease of male rats.PloS one, , Volume: 18, Issue:11, 2023
Brain-to-gut trafficking of alpha-synuclein by CD11cNature communications, , Nov-20, Volume: 14, Issue:1, 2023
Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson's disease in rodent brains.Molecular neurodegeneration, , Nov-27, Volume: 18, Issue:1, 2023
Enhanced mTORC1 signaling and protein synthesis in pathologic α-synuclein cellular and animal models of Parkinson's disease.Science translational medicine, , Nov-29, Volume: 15, Issue:724, 2023
MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson's disease.Molecular neurodegeneration, , Dec-01, Volume: 18, Issue:1, 2023
A Mouse Model of Multiple System Atrophy: Bench to Bedside.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 20, Issue:1, 2023
Synthesis of a natural quinoline alkaloid isolated from the deep-sea-derived fungus and its potential as a therapeutic for Parkinson's disease.Journal of Asian natural products research, , Volume: 25, Issue:5, 2023
Lippia grata essential oil complexed with β-cyclodextrin ameliorates biochemical and behavioral deficits in an animal model of progressive parkinsonism.Metabolic brain disease, , Volume: 37, Issue:7, 2022
Brain regions susceptible to alpha-synuclein spreading.Molecular psychiatry, , Volume: 27, Issue:1, 2022
Two-step screening method to identify α-synuclein aggregation inhibitors for Parkinson's disease.Scientific reports, , 01-10, Volume: 12, Issue:1, 2022
Ferruginol prevents degeneration of dopaminergic neurons by enhancing clearance of α-synuclein in neuronal cells.Fitoterapia, , Volume: 156, 2022
Temporal, spatial and molecular pattern of dopaminergic neurodegeneration in the AAV-A53T α-synuclein rat model of Parkinson's disease.Behavioural brain research, , 08-26, Volume: 432, 2022
Distinct Aβ pathology in the olfactory bulb and olfactory deficits in a mouse model of Aβ and α-syn co-pathology.Brain pathology (Zurich, Switzerland), , Volume: 32, Issue:3, 2022
Immunisation with UB-312 in the Thy1SNCA mouse prevents motor performance deficits and oligomeric α-synuclein accumulation in the brain and gut.Acta neuropathologica, , Volume: 143, Issue:1, 2022
The Compound ATH434 Prevents Alpha-Synuclein Toxicity in a Murine Model of Multiple System Atrophy.Journal of Parkinson's disease, , Volume: 12, Issue:1, 2022
The influence of preconditioning with low dose of LPS on paraquat-induced neurotoxicity, microglia activation and expression of α-synuclein and synphilin-1 in the dopaminergic system.Pharmacological reports : PR, , Volume: 74, Issue:1, 2022
The Effects of Novel Formulations of Edaravone and Curcumin in the Mouse Intrastriatal Lipopolysaccharide Model of Parkinson's Disease.Frontiers in bioscience (Scholar edition), , 05-07, Volume: 14, Issue:2, 2022
Intranasal Exposure to Low-Dose Rotenone Induced Alpha-Synuclein Accumulation and Parkinson's Like Symptoms Without Loss of Dopaminergic Neurons.Neurotoxicity research, , Volume: 40, Issue:1, 2022
Animal models of brain-first and body-first Parkinson's disease.Neurobiology of disease, , Volume: 163, 2022
Alpha-synuclein and cortico-striatal plasticity in animal models of Parkinson disease.Handbook of clinical neurology, , Volume: 184, 2022
Phosphorylation of endogenous α-synuclein induced by extracellular seeds initiates at the pre-synaptic region and spreads to the cell body.Scientific reports, , 01-21, Volume: 12, Issue:1, 2022
Olfactory Bulb Excitotoxicity as a Gap-Filling Mechanism Underlying the Link Between Traumatic Brain Injury-Induced Secondary Neuronal Degeneration and Parkinson's Disease-Like Pathology.Neurochemical research, , Volume: 47, Issue:4, 2022
Expansion of regulatory T cells by CD28 superagonistic antibodies attenuates neurodegeneration in A53T-α-synuclein Parkinson's disease mice.Journal of neuroinflammation, , Dec-31, Volume: 19, Issue:1, 2022
Immunogenicity of MultiTEP-Platform-Based Recombinant Protein Vaccine, PV-1950R, Targeting Three B-Cell Antigenic Determinants of Pathological α-Synuclein.International journal of molecular sciences, , May-29, Volume: 23, Issue:11, 2022
Repurposing Pomalidomide as a Neuroprotective Drug: Efficacy in an Alpha-Synuclein-Based Model of Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 19, Issue:1, 2022
Neurodegeneration and neuroinflammation are linked, but independent of alpha-synuclein inclusions, in a seeding/spreading mouse model of Parkinson's disease.Glia, , Volume: 70, Issue:5, 2022
Anti-α-synuclein Toxicity and Anti-neurodegenerative Role of Chrysin in Transgenic ACS chemical neuroscience, , 02-16, Volume: 13, Issue:4, 2022
Inflammatory Animal Models of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
Roles of α-Synuclein and Disease-Associated Factors in International journal of molecular sciences, , Jan-28, Volume: 23, Issue:3, 2022
Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological α-synuclein.Cell reports, , 02-15, Volume: 38, Issue:7, 2022
CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in huntington's disease.Acta neuropathologica communications, , 06-03, Volume: 10, Issue:1, 2022
Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson's disease.Molecular neurodegeneration, , 02-23, Volume: 17, Issue:1, 2022
Ischemic stroke causes Parkinson's disease-like pathology and symptoms in transgenic mice overexpressing alpha-synuclein.Acta neuropathologica communications, , 02-24, Volume: 10, Issue:1, 2022
Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapy.Translational psychiatry, , 02-24, Volume: 12, Issue:1, 2022
Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson's disease.Scientific reports, , 02-24, Volume: 12, Issue:1, 2022
Pharmacological Intervention Targeting FAF1 Restores Autophagic Flux for α-Synuclein Degradation in the Brain of a Parkinson's Disease Mouse Model.ACS chemical neuroscience, , 03-16, Volume: 13, Issue:6, 2022
PTEN-Induced Putative Kinase 1 Dysfunction Accelerates Synucleinopathy.Journal of Parkinson's disease, , Volume: 12, Issue:4, 2022
Gene therapy of yeast NDI1 on mitochondrial complex I dysfunction in rotenone-induced Parkinson's disease models in vitro and vivo.Molecular medicine (Cambridge, Mass.), , 03-07, Volume: 28, Issue:1, 2022
Long-term hyperglycemia aggravates α-synuclein aggregation and dopaminergic neuronal loss in a Parkinson's disease mouse model.Translational neurodegeneration, , 03-07, Volume: 11, Issue:1, 2022
Modeling Parkinson's disease-related symptoms in alpha-synuclein overexpressing mice.Brain and behavior, , Volume: 12, Issue:7, 2022
Synthesis of Evodileptin B, a Natural Anthranilate Derivative Isolated from Evodia lepta, and Evaluation of Its Therapeutic Potential against Parkinson's Disease.Chemistry & biodiversity, , Volume: 19, Issue:5, 2022
Sustained chemogenetic activation of locus coeruleus norepinephrine neurons promotes dopaminergic neuron survival in synucleinopathy.PloS one, , Volume: 17, Issue:3, 2022
Neuroprotective Effects of Cranberry Juice Treatment in a Rat Model of Parkinson's Disease.Nutrients, , May-11, Volume: 14, Issue:10, 2022
Association between Decreased ITGA7 Levels and Increased Muscle α-Synuclein in an MPTP-Induced Mouse Model of Parkinson's Disease.International journal of molecular sciences, , May-18, Volume: 23, Issue:10, 2022
A breakdown in microglial metabolic reprogramming causes internalization dysfunction of α-synuclein in a mouse model of Parkinson's disease.Journal of neuroinflammation, , May-22, Volume: 19, Issue:1, 2022
Loss of GBA in zebrafish leads to dopaminergic neurodegeneration, but overexpression of α-synuclein does not further worsen degeneration.Neuroreport, , 05-04, Volume: 33, Issue:7, 2022
SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex.Acta neuropathologica communications, , 12-14, Volume: 10, Issue:1, 2022
Effects of Lanthionine Ketimine-5-Ethyl Ester on the α-Synucleinopathy Mouse Model.Neurochemical research, , Volume: 47, Issue:8, 2022
Aggregated Alpha-Synuclein Inclusions within the Nucleus Predict Impending Neuronal Cell Death in a Mouse Model of Parkinsonism.International journal of molecular sciences, , Dec-04, Volume: 23, Issue:23, 2022
Cholecystokinin and glucagon-like peptide-1 analogues regulate intestinal tight junction, inflammation, dopaminergic neurons and α-synuclein accumulation in the colon of two Parkinson's disease mouse models.European journal of pharmacology, , Jul-05, Volume: 926, 2022
α-Synuclein Selectively Impairs Motor Sequence Learning and Value Sensitivity: Reversal by the Adenosine A2A Receptor Antagonists.Cerebral cortex (New York, N.Y. : 1991), , 02-08, Volume: 32, Issue:4, 2022
Pathophysiological Features of Nigral Dopaminergic Neurons in Animal Models of Parkinson's Disease.International journal of molecular sciences, , Apr-19, Volume: 23, Issue:9, 2022
Chitosan oligosaccharides exert neuroprotective effects Food & function, , May-23, Volume: 13, Issue:10, 2022
The proSAAS Chaperone Provides Neuroprotection and Attenuates Transsynaptic α-Synuclein Spread in Rodent Models of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:5, 2022
Inflammation promotes synucleinopathy propagation.Experimental & molecular medicine, , Volume: 54, Issue:12, 2022
Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial.EBioMedicine, , Volume: 80, 2022
Correlation between α-synuclein and fatty acid composition in jejunum of rotenone-treated mice is dependent on acyl chain length.General physiology and biophysics, , Volume: 41, Issue:6, 2022
MCC950 ameliorates the dementia symptom at the early age of line M83 mouse and reduces hippocampal α-synuclein accumulation.Biochemical and biophysical research communications, , 06-30, Volume: 611, 2022
A Novel NOX Inhibitor Treatment Attenuates Parkinson's Disease-Related Pathology in Mouse Models.International journal of molecular sciences, , Apr-12, Volume: 23, Issue:8, 2022
GM1 ganglioside modifies microglial and neuroinflammatory responses to α-synuclein in the rat AAV-A53T α-synuclein model of Parkinson's disease.Molecular and cellular neurosciences, , Volume: 120, 2022
Alpha-synuclein-mediated DNA damage, STING activation, and neuroinflammation in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 04-26, Volume: 119, Issue:17, 2022
The GBA1 D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models.Disease models & mechanisms, , 06-01, Volume: 15, Issue:6, 2022
Sesquiterpenoids isolated from davana (Artemisia pallens Wall. ex DC) mitigates parkinsonism in Caenorhabditis elegans disease model.Biochemical and biophysical research communications, , 06-18, Volume: 609, 2022
Infections of Frontiers in cellular and infection microbiology, , Volume: 12, 2022
Lateralized deficits after unilateral AAV-vector based overexpression of alpha-synuclein in the midbrain of rats on drug-free behavioral tests.Behavioural brain research, , 07-05, Volume: 429, 2022
Gastric Enteric Glial Cells: A New Contributor to the Synucleinopathies in the MPTP-Induced Parkinsonism Mouse.Molecules (Basel, Switzerland), , Nov-01, Volume: 27, Issue:21, 2022
A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice.eLife, , 11-08, Volume: 11, 2022
Non-Reproducibility of Oral Rotenone as a Model for Parkinson's Disease in Mice.International journal of molecular sciences, , Oct-21, Volume: 23, Issue:20, 2022
Reelin protects against pathological α-synuclein accumulation and dopaminergic neurodegeneration after environmental enrichment in Parkinson's disease.Neurobiology of disease, , Volume: 175, 2022
Oxidative Stress and Mitochondrial Complex I Dysfunction Correlate with Neurodegeneration in an α-Synucleinopathy Animal Model.International journal of molecular sciences, , Sep-27, Volume: 23, Issue:19, 2022
Fucosylated Chondroitin Sulfate against Parkinson's Disease through Inhibiting Inflammation Induced by Gut Dysbiosis.Journal of agricultural and food chemistry, , Oct-26, Volume: 70, Issue:42, 2022
Gut dysfunction may be the source of pathological aggregation of alpha-synuclein in the central nervous system through Paraquat exposure in mice.Ecotoxicology and environmental safety, , Volume: 246, 2022
A Combined α-Synuclein/Fibril (SynFib) Model of Parkinson-Like Synucleinopathy Targeting the Nigrostriatal Dopamine System.Journal of Parkinson's disease, , Volume: 12, Issue:8, 2022
Progress in Parkinson's disease animal models of genetic defects: Characteristics and application.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 155, 2022
Error-prone protein synthesis recapitulates early symptoms of Alzheimer disease in aging mice.Cell reports, , 09-27, Volume: 40, Issue:13, 2022
6-Hydroxydopamine-Induced Neurotoxicity in Rat Model of Parkinson's Disease: Is Reversed via Anti-Oxidative Activities of Curcumin and Aerobic Exercise Therapy.Physiological research, , Aug-31, Volume: 71, Issue:4, 2022
Thoracic trauma promotes alpha-Synuclein oligomerization in murine Parkinson's disease.Neurobiology of disease, , Volume: 174, 2022
Early Dysbiosis and Dampened Gut Microbe Oscillation Precede Motor Dysfunction and Neuropathology in Animal Models of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:8, 2022
Neuroprotective effects of cannabidiol on dopaminergic neurodegeneration and α-synuclein accumulation in C. elegans models of Parkinson's disease.Neurotoxicology, , Volume: 93, 2022
Fenofibrate promotes neuroprotection in a model of rotenone-induced Parkinson's disease.Behavioural pharmacology, , 12-01, Volume: 33, Issue:8, 2022
Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD.Molecular neurodegeneration, , 09-05, Volume: 17, Issue:1, 2022
Inhibition of α-synuclein aggregation by MT101-5 is neuroprotective in mouse models of Parkinson's disease.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 154, 2022
Amelioration of pathologic α-synuclein-induced Parkinson's disease by irisin.Proceedings of the National Academy of Sciences of the United States of America, , 09-06, Volume: 119, Issue:36, 2022
Multiple checkpoints of protein clearance machinery are modulated by a common microRNA, miR-4813-3p, through its putative target genes: Studies employing transgenic C. elegans model.Biochimica et biophysica acta. Molecular cell research, , Volume: 1869, Issue:12, 2022
Systemic RNA Interference Defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans.PLoS genetics, , Volume: 18, Issue:8, 2022
Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein.Journal of visualized experiments : JoVE, , 07-29, Issue:185, 2022
Removal of proteinase K resistant αSyn species does not correlate with cell survival in a virus vector-based Parkinson's disease mouse model.Neuropharmacology, , 11-01, Volume: 218, 2022
Synthetic Peucedanocoumarin IV Prevents α-Synuclein Neurotoxicity in an Animal Model of Parkinson's Disease.International journal of molecular sciences, , Aug-03, Volume: 23, Issue:15, 2022
Angiotensin converting enzyme inhibitor captopril prevents neuronal overexpression of amyloid-beta and alpha-synuclein in Drosophila melanogaster genetic models of neurodegenerative diseases.Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, , Jun-30, Volume: 37, Issue:1, 2022
4-Phenylbutyrate Mitigates the Motor Impairment and Dopaminergic Neuronal Death During Parkinson's Disease Pathology via Targeting VDAC1 Mediated Mitochondrial Function and Astrocytes Activation.Neurochemical research, , Volume: 47, Issue:11, 2022
NXP031 prevents dopaminergic neuronal loss and oxidative damage in the AAV-WT-α-synuclein mouse model of Parkinson's disease.PloS one, , Volume: 17, Issue:7, 2022
Inhibition of Ubiquitin-Specific Protease-13 Improves Behavioral Performance in Alpha-Synuclein Expressing Mice.International journal of molecular sciences, , Jul-23, Volume: 23, Issue:15, 2022
Immunohistochemical Demonstration of the pGlu79 α-Synuclein Fragment in Alzheimer's Disease and Its Tg2576 Mouse Model.Biomolecules, , 07-20, Volume: 12, Issue:7, 2022
Therapeutic functions of astrocytes to treat α-synuclein pathology in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 07-19, Volume: 119, Issue:29, 2022
Treadmill exercise reduces α-synuclein spreading via PPARα.Cell reports, , 07-12, Volume: 40, Issue:2, 2022
Viral-based rodent and nonhuman primate models of multiple system atrophy: Fidelity to the human disease.Neurobiology of disease, , Volume: 148, 2021
The MHC class II transactivator modulates seeded alpha-synuclein pathology and dopaminergic neurodegeneration in an in vivo rat model of Parkinson's disease.Brain, behavior, and immunity, , Volume: 91, 2021
Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson's disease model.Molecular brain, , 04-19, Volume: 14, Issue:1, 2021
Inhibition of copper transporter 1 prevents α-synuclein pathology and alleviates nigrostriatal degeneration in AAV-based mouse model of Parkinson's disease.Redox biology, , Volume: 38, 2021
BMP5/7 protect dopaminergic neurons in an α-synuclein mouse model of Parkinson's disease.Brain : a journal of neurology, , 03-03, Volume: 144, Issue:2, 2021
Exosome-mediated delivery of antisense oligonucleotides targeting α-synuclein ameliorates the pathology in a mouse model of Parkinson's disease.Neurobiology of disease, , Volume: 148, 2021
Glial activation precedes alpha-synuclein pathology in a mouse model of Parkinson's disease.Neuroscience research, , Volume: 170, 2021
Gut microbiota and metabolites of α-synuclein transgenic monkey models with early stage of Parkinson's disease.NPJ biofilms and microbiomes, , 09-02, Volume: 7, Issue:1, 2021
EphA1 Activation Induces Neuropathological Changes in a Mouse Model of Parkinson's Disease Through the CXCL12/CXCR4 Signaling Pathway.Molecular neurobiology, , Volume: 58, Issue:3, 2021
Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration.Nature communications, , 09-06, Volume: 12, Issue:1, 2021
[no title available]International journal of molecular sciences, , Aug-29, Volume: 22, Issue:17, 2021
Failure of Diphtheria Toxin Model to Induce Parkinson-Like Behavior in Mice.International journal of molecular sciences, , Aug-31, Volume: 22, Issue:17, 2021
Novel Approaches Used to Examine and Control Neurogenesis in Parkinson's Disease.International journal of molecular sciences, , Sep-04, Volume: 22, Issue:17, 2021
Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model.Molecular neurodegeneration, , 09-09, Volume: 16, Issue:1, 2021
A bibenzyl compound 20C protects rats against 6-OHDA-induced damage by regulating adaptive immunity associated molecules.International immunopharmacology, , Volume: 91, 2021
Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo.Nature communications, , 09-10, Volume: 12, Issue:1, 2021
Toll-like receptor 4 deficiency facilitates α-synuclein propagation and neurodegeneration in a mouse model of prodromal Parkinson's disease.Parkinsonism & related disorders, , Volume: 91, 2021
Therapeutic potential of iron modulating drugs in a mouse model of multiple system atrophy.Neurobiology of disease, , Volume: 159, 2021
Chitosan nanocarrier for FTY720 enhanced delivery retards Parkinson's disease via PP2A-EzH2 signaling in vitro and ex vivo.Carbohydrate polymers, , Feb-15, Volume: 254, 2021
Analysis of Brain Protein Stability Changes in Mouse Models of Normal Aging and α-Synucleinopathy Reveals Age- and Disease-Related Differences.Journal of proteome research, , 11-05, Volume: 20, Issue:11, 2021
Molecular chaperones and Parkinson's disease.Neurobiology of disease, , Volume: 160, 2021
Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies.Journal of molecular cell biology, , 08-04, Volume: 13, Issue:4, 2021
TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease.Neuron, , 12-01, Volume: 109, Issue:23, 2021
Deficient immunoproteasome assembly drives gain of α-synuclein pathology in Parkinson's disease.Redox biology, , Volume: 47, 2021
14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril model.Acta neuropathologica communications, , 01-07, Volume: 9, Issue:1, 2021
Neuroprotective effect of paeoniflorin in the mouse model of Parkinson's disease through α-synuclein/protein kinase C δ subtype signaling pathway.Neuroreport, , 12-08, Volume: 32, Issue:17, 2021
Is SGSH heterozygosity a risk factor for early-onset neurodegenerative disease?Journal of inherited metabolic disease, , Volume: 44, Issue:3, 2021
Chronic Exposure to Paraquat Induces Alpha-Synuclein Pathogenic Modifications in International journal of molecular sciences, , Oct-27, Volume: 22, Issue:21, 2021
Mechanistic Insight from Preclinical Models of Parkinson's Disease Could Help Redirect Clinical Trial Efforts in GDNF Therapy.International journal of molecular sciences, , Oct-28, Volume: 22, Issue:21, 2021
Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans.Molecular neurodegeneration, , 11-12, Volume: 16, Issue:1, 2021
Abnormal accumulation of lipid droplets in neurons induces the conversion of alpha-Synuclein to proteolytic resistant forms in a Drosophila model of Parkinson's disease.PLoS genetics, , Volume: 17, Issue:11, 2021
Human alpha-synuclein overexpressing MBP29 mice mimic functional and structural hallmarks of the cerebellar subtype of multiple system atrophy.Acta neuropathologica communications, , 04-14, Volume: 9, Issue:1, 2021
α-synuclein suppresses microglial autophagy and promotes neurodegeneration in a mouse model of Parkinson's disease.Aging cell, , Volume: 20, Issue:12, 2021
Human α-synuclein overexpression in a mouse model of Parkinson's disease leads to vascular pathology, blood brain barrier leakage and pericyte activation.Scientific reports, , 01-13, Volume: 11, Issue:1, 2021
Autophagy in α-Synucleinopathies-An Overstrained System.Cells, , 11-12, Volume: 10, Issue:11, 2021
A SUMO1-Derived Peptide Targeting SUMO-Interacting Motif Inhibits α-Synuclein Aggregation.Cell chemical biology, , 02-18, Volume: 28, Issue:2, 2021
Slow-wave sleep affects synucleinopathy and regulates proteostatic processes in mouse models of Parkinson's disease.Science translational medicine, , 12-08, Volume: 13, Issue:623, 2021
Decrease in International journal of molecular sciences, , Nov-23, Volume: 22, Issue:23, 2021
Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson's Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment.Frontiers in immunology, , Volume: 12, 2021
Effect of Docosahexaenoic Acid (DHA) at the Enteric Level in a Synucleinopathy Mouse Model.Nutrients, , Nov-24, Volume: 13, Issue:12, 2021
Inhibition of Orexin/Hypocretin Neurons Ameliorates Elevated Physical Activity and Energy Expenditure in the A53T Mouse Model of Parkinson's Disease.International journal of molecular sciences, , Jan-14, Volume: 22, Issue:2, 2021
Velvet Antler Methanol Extracts Ameliorate Parkinson's Disease by Inhibiting Oxidative Stress and Neuroinflammation: From Oxidative medicine and cellular longevity, , Volume: 2021, 2021
Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration.Molecular therapy : the journal of the American Society of Gene Therapy, , 05-05, Volume: 29, Issue:5, 2021
α-Synuclein Spread from Olfactory Bulb Causes Hyposmia, Anxiety, and Memory Loss in BAC-SNCA Mice.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:9, 2021
The gut-brain connection in the pathogenicity of Parkinson disease: Putative role of autophagy.Neuroscience letters, , 05-14, Volume: 753, 2021
α-synuclein impairs autophagosome maturation through abnormal actin stabilization.PLoS genetics, , Volume: 17, Issue:2, 2021
In vivo aggregation of presynaptic alpha-synuclein is not influenced by its phosphorylation at serine-129.Neurobiology of disease, , Volume: 152, 2021
A New Synuclein-Transgenic Mouse Model for Early Parkinson's Reveals Molecular Features of Preclinical Disease.Molecular neurobiology, , Volume: 58, Issue:2, 2021
Retina as a Model to Study In Vivo Transmission of α-Synuclein in the A53T Mouse Model of Parkinson's Disease.Methods in molecular biology (Clifton, N.J.), , Volume: 2224, 2021
Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models.Communications biology, , 02-19, Volume: 4, Issue:1, 2021
Amyloid Structural Changes Studied by Infrared Microspectroscopy in Bigenic Cellular Models of Alzheimer's Disease.International journal of molecular sciences, , Mar-26, Volume: 22, Issue:7, 2021
Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain.Acta neuropathologica communications, , 02-25, Volume: 9, Issue:1, 2021
Intracerebral Administration of a Ligand-ASO Conjugate Selectively Reduces α-Synuclein Accumulation in Monoamine Neurons of Double Mutant Human A30P*A53T*α-Synuclein Transgenic Mice.International journal of molecular sciences, , Mar-13, Volume: 22, Issue:6, 2021
Age-related increase of alpha-synuclein oligomers is associated with motor disturbances in L61 transgenic mice.Neurobiology of aging, , Volume: 101, 2021
α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson's disease.JCI insight, , 03-08, Volume: 6, Issue:5, 2021
Reduced Interaction of Aggregated α-Synuclein and VAMP2 by Environmental Enrichment Alleviates Hyperactivity and Anxiety in a Model of Parkinson's Disease.Genes, , 03-10, Volume: 12, Issue:3, 2021
ATH434 Reduces α-Synuclein-Related Neurodegeneration in a Murine Model of Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:11, 2021
Further Characterization of Intrastriatal Lipopolysaccharide Model of Parkinson's Disease in C57BL/6 Mice.International journal of molecular sciences, , Jul-09, Volume: 22, Issue:14, 2021
Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson's disease.Cell reports, , 07-06, Volume: 36, Issue:1, 2021
Intracranial administration of alpha-synuclein fibrils in A30P-synuclein transgenic mice causes robust synucleinopathy and microglial induction.Neurobiology of aging, , Volume: 106, 2021
Saffron ameliorated motor symptoms, short life span and retinal degeneration in Parkinson's disease fly models.Gene, , Oct-05, Volume: 799, 2021
Preformed fibrils generated from mouse alpha-synuclein produce more inclusion pathology in rats than fibrils generated from rat alpha-synuclein.Parkinsonism & related disorders, , Volume: 89, 2021
The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo.International journal of molecular sciences, , Jun-23, Volume: 22, Issue:13, 2021
Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson's Disease Models.Cells, , 07-05, Volume: 10, Issue:7, 2021
Increased telomerase improves motor function and alpha-synuclein pathology in a transgenic mouse model of Parkinson's disease associated with enhanced autophagy.Progress in neurobiology, , Volume: 199, 2021
Neuroprotective Effects of Trehalose and Sodium Butyrate on Preformed Fibrillar Form of α-Synuclein-Induced Rat Model of Parkinson's Disease.ACS chemical neuroscience, , 07-21, Volume: 12, Issue:14, 2021
Equine pituitary pars intermedia dysfunction: a spontaneous model of synucleinopathy.Scientific reports, , 08-06, Volume: 11, Issue:1, 2021
Inhibition of Oxidative medicine and cellular longevity, , Volume: 2021, 2021
[The novel mechanism of α-synuclein propagation in synucleinopathy].Nihon yakurigaku zasshi. Folia pharmacologica Japonica, , Volume: 156, Issue:4, 2021
ATH434 Reverses Colorectal Dysfunction in the A53T Mouse Model of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 11, Issue:4, 2021
Queuine, a bacterial-derived hypermodified nucleobase, shows protection in in vitro models of neurodegeneration.PloS one, , Volume: 16, Issue:8, 2021
VPS35 D620N knockin mice recapitulate cardinal features of Parkinson's disease.Aging cell, , Volume: 20, Issue:5, 2021
Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson's disease.Acta neuropathologica communications, , 03-20, Volume: 9, Issue:1, 2021
DNAJB6 suppresses alpha-synuclein induced pathology in an animal model of Parkinson's disease.Neurobiology of disease, , Volume: 158, 2021
Intranasal Carnosine Mitigates α-Synuclein Pathology and Motor Dysfunction in the Thy1-aSyn Mouse Model of Parkinson's Disease.ACS chemical neuroscience, , 07-07, Volume: 12, Issue:13, 2021
Inflammation in Experimental Models of α-Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:1, 2021
An extended release GLP-1 analogue increases α-synuclein accumulation in a mouse model of prodromal Parkinson's disease.Experimental neurology, , Volume: 341, 2021
Intranasal infusion of GD3 and GM1 gangliosides downregulates alpha-synuclein and controls tyrosine hydroxylase gene in a PD model mouse.Molecular therapy : the journal of the American Society of Gene Therapy, , 10-06, Volume: 29, Issue:10, 2021
Peripheral inflammation exacerbates α-synuclein toxicity and neuropathology in Parkinson's models.Neuropathology and applied neurobiology, , Volume: 47, Issue:1, 2021
Monitoring of a progressive functional dopaminergic deficit in the A53T-AAV synuclein rats by combining 6-[Neurobiology of aging, , Volume: 107, 2021
Neurorescue Effects of Frondoside A and Ginsenoside Rg3 in Molecules (Basel, Switzerland), , Aug-10, Volume: 26, Issue:16, 2021
Preface to an editorial controversy on α-synuclein: How good are cellular models?: This is a Preface for an Editorial controversy between Hilal A. Lashuel "Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complemenJournal of neurochemistry, , Volume: 157, Issue:4, 2021
Nasal Rifampicin Improves Cognition in a Mouse Model of Dementia with Lewy Bodies by Reducing α-Synuclein Oligomers.International journal of molecular sciences, , Aug-06, Volume: 22, Issue:16, 2021
Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates α-synuclein Pathology in a Mouse Model of α-Synuclein Propagation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 18, Issue:2, 2021
CD4 T cells mediate brain inflammation and neurodegeneration in a mouse model of Parkinson's disease.Brain : a journal of neurology, , 08-17, Volume: 144, Issue:7, 2021
Psychosis-Like Behavior and Hyperdopaminergic Dysregulation in Human α-Synuclein BAC Transgenic Rats.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:3, 2021
Alpha-synuclein increases in rodent and human spinal cord injury and promotes inflammation and tissue loss.Scientific reports, , 06-03, Volume: 11, Issue:1, 2021
Reduced erythrocytic CHCHD2 mRNA is associated with brain pathology of Parkinson's disease.Acta neuropathologica communications, , 03-08, Volume: 9, Issue:1, 2021
Alpha-Synuclein-induced DNA Methylation and Gene Expression in Microglia.Neuroscience, , 08-01, Volume: 468, 2021
Identification of amyloidogenic proteins in the microbiomes of a rat Parkinson's disease model and wild-type rats.Protein science : a publication of the Protein Society, , Volume: 30, Issue:9, 2021
α-Synuclein A53T Binds to Transcriptional Adapter 2-Alpha and Blocks Histone H3 Acetylation.International journal of molecular sciences, , May-20, Volume: 22, Issue:10, 2021
Complement and Coagulation Cascades are Potentially Involved in Dopaminergic Neurodegeneration in α-Synuclein-Based Mouse Models of Parkinson's Disease.Journal of proteome research, , 07-02, Volume: 20, Issue:7, 2021
Mesenchymal stem cell secretome protects against alpha-synuclein-induced neurodegeneration in a Caenorhabditis elegans model of Parkinson's disease.Cytotherapy, , Volume: 23, Issue:10, 2021
Common Marmoset Model of α-Synuclein Propagation.Methods in molecular biology (Clifton, N.J.), , Volume: 2322, 2021
α-Synuclein Propagation Mouse Models of Parkinson's Disease.Methods in molecular biology (Clifton, N.J.), , Volume: 2322, 2021
Lycorine, a natural alkaloid, promotes the degradation of alpha-synuclein via PKA-mediated UPS activation in transgenic Parkinson's disease models.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 87, 2021
Prodromal sensory neuropathy in Pink1Neuropathology and applied neurobiology, , Volume: 47, Issue:7, 2021
Wild-type α-synuclein inherits the structure and exacerbated neuropathology of E46K mutant fibril strain by cross-seeding.Proceedings of the National Academy of Sciences of the United States of America, , 05-18, Volume: 118, Issue:20, 2021
Cerebral dopamine neurotrophic factor reduces α-synuclein aggregation and propagation and alleviates behavioral alterations in vivo.Molecular therapy : the journal of the American Society of Gene Therapy, , 09-01, Volume: 29, Issue:9, 2021
Preclinical Detection of Alpha-Synuclein Seeding Activity in the Colon of a Transgenic Mouse Model of Synucleinopathy by RT-QuIC.Viruses, , 04-26, Volume: 13, Issue:5, 2021
The Contribution of Microglia to Neuroinflammation in Parkinson's Disease.International journal of molecular sciences, , Apr-28, Volume: 22, Issue:9, 2021
Changes in Drp1 Function and Mitochondrial Morphology Are Associated with the α-Synuclein Pathology in a Transgenic Mouse Model of Parkinson's Disease.Cells, , 04-13, Volume: 10, Issue:4, 2021
Neuroprotective effect of metformin on dopaminergic neurodegeneration and α-synuclein aggregation in C. elegans model of Parkinson's disease.Neuroscience research, , Volume: 162, 2021
Pramipexole attenuates 6-OHDA-induced Parkinson's disease by mediating the Nurr1/NF-κB pathway.Molecular biology reports, , Volume: 48, Issue:4, 2021
Administration of quercetin improves mitochondria quality control and protects the neurons in 6-OHDA-lesioned Parkinson's disease models.Aging, , 04-20, Volume: 13, Issue:8, 2021
Deciphering the robustness of pyrazolo-pyridine carboxylate core structure-based compounds for inhibiting α-synuclein in transgenic C. elegans model of Synucleinopathy.Bioorganic & medicinal chemistry, , 09-01, Volume: 28, Issue:17, 2020
Discoidin Domain Receptor 1 is a therapeutic target for neurodegenerative diseases.Human molecular genetics, , 10-10, Volume: 29, Issue:17, 2020
Neuroprotection of Rotenone-Induced Parkinsonism by Ursolic Acid in PD Mouse Model.CNS & neurological disorders drug targets, , Volume: 19, Issue:7, 2020
Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions.Acta neuropathologica communications, , 08-12, Volume: 8, Issue:1, 2020
Effect of kaempferol on the transgenic Drosophila model of Parkinson's disease.Scientific reports, , 08-14, Volume: 10, Issue:1, 2020
Quantitative Profiling of Synuclein Species: Application to Transgenic Mouse Models of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 10, Issue:2, 2020
Nose to brain delivery of rotigotine loaded chitosan nanoparticles in human SH-SY5Y neuroblastoma cells and animal model of Parkinson's disease.International journal of pharmaceutics, , Apr-15, Volume: 579, 2020
α-Synuclein promotes IAPP fibril formation in vitro and β-cell amyloid formation in vivo in mice.Scientific reports, , 11-24, Volume: 10, Issue:1, 2020
T cell infiltration and upregulation of MHCII in microglia leads to accelerated neuronal loss in an α-synuclein rat model of Parkinson's disease.Journal of neuroinflammation, , Aug-15, Volume: 17, Issue:1, 2020
Cell type-specific lipid storage changes in Parkinson's disease patient brains are recapitulated by experimental glycolipid disturbance.Proceedings of the National Academy of Sciences of the United States of America, , 11-03, Volume: 117, Issue:44, 2020
Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys.EBioMedicine, , Volume: 59, 2020
Impact of Age and Sex on α-Syn (α-Synuclein) Knockdown-Mediated Poststroke Recovery.Stroke, , Volume: 51, Issue:10, 2020
Novel fatty acid-binding protein 3 ligand inhibits dopaminergic neuronal death and improves motor and cognitive impairments in Parkinson's disease model mice.Pharmacology, biochemistry, and behavior, , Volume: 191, 2020
Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy.Acta neuropathologica communications, , 08-28, Volume: 8, Issue:1, 2020
A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function.Nature structural & molecular biology, , Volume: 27, Issue:3, 2020
Evaluating the Effects of Grain of Isogenic Wheat Lines Differing in the Content of Anthocyanins in Mouse Models of Neurodegenerative Disorders.Nutrients, , Dec-18, Volume: 12, Issue:12, 2020
Immunoproteasome is up-regulated in rotenone-induced Parkinson's disease rat model.Neuroscience letters, , 11-01, Volume: 738, 2020
Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration.Nature communications, , 03-13, Volume: 11, Issue:1, 2020
Downregulation of α-Synuclein Protein Levels by an Intracellular Single-Chain Antibody.Journal of Parkinson's disease, , Volume: 10, Issue:2, 2020
The function of bacterial HtrA is evolutionally conserved in mammalian HtrA2/Omi.Scientific reports, , 03-24, Volume: 10, Issue:1, 2020
Squalamine Restores the Function of the Enteric Nervous System in Mouse Models of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 10, Issue:4, 2020
Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice.Neurobiology of aging, , Volume: 91, 2020
Perturbation of in vivo Neural Activity Following α-Synuclein Seeding in the Olfactory Bulb.Journal of Parkinson's disease, , Volume: 10, Issue:4, 2020
Metabolomics Fingerprint Induced by the Intranigral Inoculation of Exogenous Human Alpha-Synuclein Oligomers in a Rat Model of Parkinson's Disease.International journal of molecular sciences, , Sep-14, Volume: 21, Issue:18, 2020
Tianma Gouteng granules decreases the susceptibility of Parkinson's disease by inhibiting ALOX15-mediated lipid peroxidation.Journal of ethnopharmacology, , Jun-28, Volume: 256, 2020
Healthspan Maintenance and Prevention of Parkinson's-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in International journal of molecular sciences, , Apr-08, Volume: 21, Issue:7, 2020
Alpha-Synuclein deficiency ameliorates chronic methamphetamine induced neurodegeneration in mice.Toxicology, , 05-30, Volume: 438, 2020
Pathogenic LRRK2 requires secondary factors to induce cellular toxicity.Bioscience reports, , 10-30, Volume: 40, Issue:10, 2020
Current Symptomatic and Disease-Modifying Treatments in Multiple System Atrophy.International journal of molecular sciences, , Apr-16, Volume: 21, Issue:8, 2020
Unilateral intranigral administration of β-sitosterol β-D-glucoside triggers pathological α-synuclein spreading and bilateral nigrostriatal dopaminergic neurodegeneration in the rat.Acta neuropathologica communications, , 04-22, Volume: 8, Issue:1, 2020
CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease.Nature communications, , 09-28, Volume: 11, Issue:1, 2020
Autophagy prevents hippocampal α-synuclein oligomerization and early cognitive dysfunction after anesthesia/surgery in aged rats.Aging, , 04-26, Volume: 12, Issue:8, 2020
S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson's disease.PloS one, , Volume: 15, Issue:4, 2020
Synj1 haploinsufficiency causes dopamine neuron vulnerability and alpha-synuclein accumulation in mice.Human molecular genetics, , 08-11, Volume: 29, Issue:14, 2020
Chronic Systemic Exposure to Low-Dose Rotenone Induced Central and Peripheral Neuropathology and Motor Deficits in Mice: Reproducible Animal Model of Parkinson's Disease.International journal of molecular sciences, , May-04, Volume: 21, Issue:9, 2020
Glucocerebrosidase deficiency promotes release of α-synuclein fibrils from cultured neurons.Human molecular genetics, , 06-27, Volume: 29, Issue:10, 2020
Propagated α-synucleinopathy recapitulates REM sleep behaviour disorder followed by parkinsonian phenotypes in mice.Brain : a journal of neurology, , 12-05, Volume: 143, Issue:11, 2020
Reduced oligodendrocyte exosome secretion in multiple system atrophy involves SNARE dysfunction.Brain : a journal of neurology, , 06-01, Volume: 143, Issue:6, 2020
Modelling cognitive deficits in Parkinson's disease: Is CA2 a gateway for hippocampal synucleinopathy?Experimental neurology, , Volume: 330, 2020
Astrocyte glutamate transporters are increased in an early sporadic model of synucleinopathy.Neurochemistry international, , Volume: 138, 2020
Experimental models of prion-like protein propagation.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 40, Issue:5, 2020
Healthspan Enhancement by Olive Polyphenols in International journal of molecular sciences, , May-29, Volume: 21, Issue:11, 2020
Biophysical studies of protein misfolding and aggregation in Quarterly reviews of biophysics, , 06-04, Volume: 49, 2020
Sirt1/FoxO1-Associated MAO-A Upregulation Promotes Depressive-Like Behavior in Transgenic Mice Expressing Human A53T α-Synuclein.ACS chemical neuroscience, , 11-18, Volume: 11, Issue:22, 2020
Assessment of the Retina of Plp-α-Syn Mice as a Model for Studying Synuclein-Dependent Diseases.Investigative ophthalmology & visual science, , 06-03, Volume: 61, Issue:6, 2020
Modeling Parkinson's Disease Neuropathology and Symptoms by Intranigral Inoculation of Preformed Human α-Synuclein Oligomers.International journal of molecular sciences, , Nov-12, Volume: 21, Issue:22, 2020
TDP-1/TDP-43 potentiates human α-Synuclein (HASN) neurodegeneration in Caenorhabditis elegans.Biochimica et biophysica acta. Molecular basis of disease, , 10-01, Volume: 1866, Issue:10, 2020
Phosphorylation and oligomerization of α-synuclein associated with GSK-3β activation in the rTg4510 mouse model of tauopathy.Acta neuropathologica communications, , 06-19, Volume: 8, Issue:1, 2020
Fasudil Promotes α-Synuclein Clearance in an AAV-Mediated α-Synuclein Rat Model of Parkinson's Disease by Autophagy Activation.Journal of Parkinson's disease, , Volume: 10, Issue:3, 2020
Structural brain changes in Ser129-phosphorylated alpha-synuclein rats based on voxel-based morphometry.Behavioural brain research, , 09-01, Volume: 393, 2020
Parkinson's disease a futile entangle of Mankind's credence on an herbal remedy: A review.Life sciences, , Sep-15, Volume: 257, 2020
Genetic Variation in Complex Traits in Transgenic α-Synuclein Strains of Genes, , 07-11, Volume: 11, Issue:7, 2020
Prolongation of metallothionein induction combats Aß and α-synuclein toxicity in aged transgenic Caenorhabditis elegans.Scientific reports, , 07-16, Volume: 10, Issue:1, 2020
IL-1β/IL-1R1 signaling induced by intranasal lipopolysaccharide infusion regulates alpha-Synuclein pathology in the olfactory bulb, substantia nigra and striatum.Brain pathology (Zurich, Switzerland), , Volume: 30, Issue:6, 2020
Classification of α-synuclein-induced changes in the AAV α-synuclein rat model of Parkinson's disease using electrophysiological measurements of visual processing.Scientific reports, , 07-17, Volume: 10, Issue:1, 2020
Ropinirole silver nanocomposite attenuates neurodegeneration in the transgenic Drosophila melanogaster model of Parkinson's disease.Neuropharmacology, , 10-15, Volume: 177, 2020
Papaverine inhibits α-synuclein aggregation by modulating neuroinflammation and matrix metalloproteinase-3 expression in the subacute MPTP/P mouse model of Parkinson's disease.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 130, 2020
Korean Red Ginseng Regulates Intestinal Tight Junction and Inflammation in the Colon of a Parkinson's Disease Mouse Model.Journal of medicinal food, , Volume: 23, Issue:12, 2020
Carboxy-terminal truncation and phosphorylation of α-synuclein elongates survival in a prion-like seeding mouse model of synucleinopathy.Neuroscience letters, , 07-27, Volume: 732, 2020
Propofol Attenuates α-Synuclein Aggregation and Neuronal Damage in a Mouse Model of Ischemic Stroke.Neuroscience bulletin, , Volume: 36, Issue:3, 2020
Neural connectivity predicts spreading of alpha-synuclein pathology in fibril-injected mouse models: Involvement of retrograde and anterograde axonal propagation.Neurobiology of disease, , Volume: 134, 2020
Bioluminescence Imaging of Neuroinflammation in a Mouse Model of Parkinson's Disease.Methods in molecular biology (Clifton, N.J.), , Volume: 2081, 2020
FTY720-Mitoxy reduces synucleinopathy and neuroinflammation, restores behavior and mitochondria function, and increases GDNF expression in Multiple System Atrophy mouse models.Experimental neurology, , Volume: 325, 2020
Stress-induced p53 drives BAG5 cochaperone expression to control α-synuclein aggregation in Parkinson's disease.Aging, , 10-21, Volume: 12, Issue:20, 2020
Loss of fragile X mental retardation protein precedes Lewy pathology in Parkinson's disease.Acta neuropathologica, , Volume: 139, Issue:2, 2020
α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson's disease model.Brain : a journal of neurology, , 01-01, Volume: 143, Issue:1, 2020
Neuroprotective effects of Bacopa monnieri in Parkinson's disease model.Metabolic brain disease, , Volume: 35, Issue:3, 2020
Using carrot cells as biofactories and oral delivery vehicles of LTB-Syn: A low-cost vaccine candidate against synucleinopathies.Journal of biotechnology, , Feb-10, Volume: 309, 2020
Global ubiquitome analysis of substantia nigra in doubly-mutant human alpha-synuclein transgenic mice.Behavioural brain research, , 02-17, Volume: 380, 2020
Reduced cerebral blood flow in an Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 40, Issue:12, 2020
The neuroprotective effect of fullerenols on a model of Parkinson's disease in Drosophila melanogaster.Biochemical and biophysical research communications, , 03-05, Volume: 523, Issue:2, 2020
Acupuncture Inhibits the Increase in Alpha-Synuclein in Substantia Nigra in an MPTP- Induced Parkinsonism Mouse Model.Advances in experimental medicine and biology, , Volume: 1232, 2020
NK cells clear α-synuclein and the depletion of NK cells exacerbates synuclein pathology in a mouse model of α-synucleinopathy.Proceedings of the National Academy of Sciences of the United States of America, , 01-21, Volume: 117, Issue:3, 2020
A new avenue for treating Parkinson's disease targeted at aggrephagy modulation and neuroinflammation: Insights from in vitro and animal studies.EBioMedicine, , Volume: 51, 2020
High-salt diet does not boost neuroinflammation and neurodegeneration in a model of α-synucleinopathy.Journal of neuroinflammation, , Jan-24, Volume: 17, Issue:1, 2020
Amyloid aggregates of the deubiquitinase OTUB1 are neurotoxic, suggesting that they contribute to the development of Parkinson's disease.The Journal of biological chemistry, , 03-13, Volume: 295, Issue:11, 2020
RT-QuIC-based detection of alpha-synuclein seeding activity in brains of dementia with Lewy Body patients and of a transgenic mouse model of synucleinopathy.Prion, , Volume: 14, Issue:1, 2020
Autonomic ganglionic injection of α-synuclein fibrils as a model of pure autonomic failure α-synucleinopathy.Nature communications, , 02-18, Volume: 11, Issue:1, 2020
The Leukotriene Receptor Antagonist Montelukast Reduces Alpha-Synuclein Load and Restores Memory in an Animal Model of Dementia with Lewy Bodies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 17, Issue:3, 2020
Effects of Exercise and Ferulic Acid on Alpha Synuclein and Neuroprotective Heat Shock Protein 70 in An Experimental Model of Parkinsonism Disease.CNS & neurological disorders drug targets, , Volume: 18, Issue:2, 2019
The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy.Biochimica et biophysica acta. Molecular basis of disease, , 11-01, Volume: 1865, Issue:11, 2019
PARP Inhibitors and Parkinson's Disease.The New England journal of medicine, , 01-31, Volume: 380, Issue:5, 2019
Anti-Parkinson activity of bioactive substances extracted from Holothuria leucospilota.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 109, 2019
Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis.Nature communications, , 03-07, Volume: 10, Issue:1, 2019
Effect of Genistein on the Transgenic Journal of dietary supplements, , Volume: 16, Issue:5, 2019
Can GBA1-Associated Parkinson Disease Be Modeled in the Mouse?Trends in neurosciences, , Volume: 42, Issue:9, 2019
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Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils.Neurobiology of disease, , Volume: 130, 2019
Peripheral Inflammation Regulates CNS Immune Surveillance Through the Recruitment of Inflammatory Monocytes Upon Systemic α-Synuclein Administration.Frontiers in immunology, , Volume: 10, 2019
The physiological role of α-synuclein and its relationship to Parkinson's Disease.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Cardiolipin remodeling by ALCAT1 links mitochondrial dysfunction to Parkinson's diseases.Aging cell, , Volume: 18, Issue:3, 2019
Glial α-synuclein promotes neurodegeneration characterized by a distinct transcriptional program in vivo.Glia, , Volume: 67, Issue:10, 2019
The A30P α-synuclein mutation decreases subventricular zone proliferation.Human molecular genetics, , 07-15, Volume: 28, Issue:14, 2019
Age- and α-Synuclein-Dependent Degeneration of Dopamine and Noradrenaline Neurons in the Annual Killifish Nothobranchius furzeri.Cell reports, , 02-12, Volume: 26, Issue:7, 2019
[Prion and Prion-like Proteins].Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, , Volume: 139, Issue:7, 2019
The toxin MPTP generates similar cognitive and locomotor deficits in hTau and tau knock-out mice.Brain research, , 05-15, Volume: 1711, 2019
A Proposed Roadmap for Parkinson's Disease Proof of Concept Clinical Trials Investigating Compounds Targeting Alpha-Synuclein.Journal of Parkinson's disease, , Volume: 9, Issue:1, 2019
Gold nanoclusters for Parkinson's disease treatment.Biomaterials, , Volume: 194, 2019
The Role of Antibodies and Their Receptors in Protection Against Ordered Protein Assembly in Neurodegeneration.Frontiers in immunology, , Volume: 10, 2019
Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats.Acta neuropathologica, , Volume: 138, Issue:4, 2019
Studying Parkinson's disease using Caenorhabditis elegans models in microfluidic devices.Integrative biology : quantitative biosciences from nano to macro, , 05-01, Volume: 11, Issue:5, 2019
E46K mutant α-synuclein is more degradation resistant and exhibits greater toxic effects than wild-type α-synuclein in Drosophila models of Parkinson's disease.PloS one, , Volume: 14, Issue:6, 2019
Colonic electrical stimulation improves colonic transit in rotenone-induced Parkinson's disease model through affecting enteric neurons.Life sciences, , Aug-15, Volume: 231, 2019
Retinal α-synuclein deposits in Parkinson's disease patients and animal models.Acta neuropathologica, , Volume: 137, Issue:3, 2019
Layer-specific axonal degeneration of serotonergic fibers in the prefrontal cortex of aged A53T α-synuclein-expressing mice.Neurobiology of aging, , Volume: 80, 2019
Twendee X Ameliorates Phosphorylated Tau, α-Synuclein and Neurovascular Dysfunction in Alzheimer's Disease Transgenic Mice With Chronic Cerebral Hypoperfusion.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, , Volume: 28, Issue:10, 2019
Chronic Mild Gut Inflammation Accelerates Brain Neuropathology and Motor Dysfunction in α-Synuclein Mutant Mice.Neuromolecular medicine, , Volume: 21, Issue:3, 2019
TREM2 deficiency aggravates α-synuclein-induced neurodegeneration and neuroinflammation in Parkinson's disease models.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 33, Issue:11, 2019
Disease model organism for Parkinson disease: Drosophila melanogaster.BMB reports, , Volume: 52, Issue:4, 2019
Neuroprotective effects of lithium on a chronic MPTP mouse model of Parkinson's disease via regulation of α‑synuclein methylation.Molecular medicine reports, , Volume: 19, Issue:6, 2019
Regulatory Mechanism of miR-543-3p on GLT-1 in a Mouse Model of Parkinson's Disease.ACS chemical neuroscience, , 03-20, Volume: 10, Issue:3, 2019
Semaglutide is Neuroprotective and Reduces α-Synuclein Levels in the Chronic MPTP Mouse Model of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 9, Issue:1, 2019
Treadmill exercise intervention improves gait and postural control in alpha-synuclein mouse models without inducing cerebral autophagy.Behavioural brain research, , 05-02, Volume: 363, 2019
Triggers, Facilitators, and Aggravators: Redefining Parkinson's Disease Pathogenesis.Trends in neurosciences, , Volume: 42, Issue:1, 2019
l-3,4-dihydroxyphenylalanine (l-DOPA) modulates brain iron, dopaminergic neurodegeneration and motor dysfunction in iron overload and mutant alpha-synuclein mouse models of Parkinson's disease.Journal of neurochemistry, , Volume: 150, Issue:1, 2019
Cardiac sympathetic innervation in the MPTP non-human primate model of Parkinson disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 29, Issue:4, 2019
Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia.The Journal of experimental medicine, , 06-03, Volume: 216, Issue:6, 2019
Monitoring α-Synuclein Proteotoxicity in Drosophila Models.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
Viral mimetic priming enhances α-synuclein-induced degeneration: Implications for Parkinson's disease.Brain, behavior, and immunity, , Volume: 80, 2019
Comparative analyses of the in vivo induction and transmission of α-synuclein pathology in transgenic mice by MSA brain lysate and recombinant α-synuclein fibrils.Acta neuropathologica communications, , 05-20, Volume: 7, Issue:1, 2019
Monitoring α-synuclein multimerization in vivo.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 33, Issue:2, 2019
C. elegans as a Model for Synucleinopathies and Other Neurodegenerative Diseases: Tools and Techniques.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
Modeling Parkinson's disease in adult Drosophila.Journal of neuroscience methods, , 01-01, Volume: 311, 2019
Oral and intravenous transmission of α-synuclein fibrils to mice.Acta neuropathologica, , Volume: 138, Issue:4, 2019
Naturally occurring autoantibodies against α-synuclein rescues memory and motor deficits and attenuates α-synuclein pathology in mouse model of Parkinson's disease.Neurobiology of disease, , Volume: 124, 2019
Evaluation of Carnosine Intervention in the Thy1-aSyn Mouse Model of Parkinson's Disease.Neuroscience, , 07-15, Volume: 411, 2019
The Role of NOX4 in Parkinson's Disease with Dementia.International journal of molecular sciences, , Feb-06, Volume: 20, Issue:3, 2019
TLR4 absence reduces neuroinflammation and inflammasome activation in Parkinson's diseases in vivo model.Brain, behavior, and immunity, , Volume: 76, 2019
Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models.Acta neuropathologica, , Volume: 138, Issue:3, 2019
α-synuclein oligomers enhance astrocyte-induced synapse formation through TGF-β1 signaling in a Parkinson's disease model.Journal of neurochemistry, , Volume: 150, Issue:2, 2019
Anle138b modulates α-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:2, 2019
Accelerated accumulation of retinal α-synuclein (pSer129) and tau, neuroinflammation, and autophagic dysregulation in a seeded mouse model of Parkinson's disease.Neurobiology of disease, , Volume: 121, 2019
GBA haploinsufficiency accelerates alpha-synuclein pathology with altered lipid metabolism in a prodromal model of Parkinson's disease.Human molecular genetics, , 06-01, Volume: 28, Issue:11, 2019
Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.Nature communications, , 04-18, Volume: 10, Issue:1, 2019
PET imaging of the influence of physiological and pathological α-synuclein on dopaminergic and serotonergic neurotransmission in mouse models.CNS neuroscience & therapeutics, , Volume: 25, Issue:1, 2019
AAV2/DJ-mediated alpha-synuclein overexpression in the rat substantia nigra as early stage model of Parkinson's disease.Cell and tissue research, , Volume: 378, Issue:1, 2019
Defining α-synuclein species responsible for Parkinson's disease phenotypes in mice.The Journal of biological chemistry, , 07-05, Volume: 294, Issue:27, 2019
Neurodegeneration and contralateral α-synuclein induction after intracerebral α-synuclein injections in the anterior olfactory nucleus of a Parkinson's disease A53T mouse model.Acta neuropathologica communications, , 04-15, Volume: 7, Issue:1, 2019
The effect of mutant GBA1 on accumulation and aggregation of α-synuclein.Human molecular genetics, , 06-01, Volume: 28, Issue:11, 2019
Acupuncture Inhibits the Increase in Alpha-Synuclein by Modulating SGK1 in an MPTP Induced Parkinsonism Mouse Model.The American journal of Chinese medicine, , Volume: 47, Issue:3, 2019
Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model.Acta neuropathologica, , Volume: 138, Issue:4, 2019
Tyrosol, a simple phenol from EVOO, targets multiple pathogenic mechanisms of neurodegeneration in a C. elegans model of Parkinson's disease.Neurobiology of aging, , Volume: 82, 2019
Ginsenoside Rb1 prevents MPTP-induced changes in hippocampal memory via regulation of the α-synuclein/PSD-95 pathway.Aging, , 04-04, Volume: 11, Issue:7, 2019
Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson's disease.Molecular neurodegeneration, , 08-16, Volume: 14, Issue:1, 2019
Parkinson's disease is a type of amyloidosis featuring accumulation of amyloid fibrils of α-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , 09-03, Volume: 116, Issue:36, 2019
AAA+ Protein-Based Technologies to Counter Neurodegenerative Disease.Biophysical journal, , 04-23, Volume: 116, Issue:8, 2019
Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies.JCI insight, , 08-22, Volume: 4, Issue:16, 2019
Exploring the Peripheral Initiation of Parkinson's Disease in Animal Models.Neuron, , 08-21, Volume: 103, Issue:4, 2019
Seeding of protein aggregation causes cognitive impairment in rat model of cortical synucleinopathy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:11, 2019
Neuroprotective effects of Astilbin on MPTP-induced Parkinson's disease mice: Glial reaction, α-synuclein expression and oxidative stress.International immunopharmacology, , Volume: 66, 2019
Early defects in translation elongation factor 1α levels at excitatory synapses in α-synucleinopathy.Acta neuropathologica, , Volume: 138, Issue:6, 2019
Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson's disease.Nature communications, , 09-02, Volume: 10, Issue:1, 2019
Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology.Molecular therapy : the journal of the American Society of Gene Therapy, , 12-04, Volume: 27, Issue:12, 2019
Slow Progressive Accumulation of Oligodendroglial Alpha-Synuclein (α-Syn) Pathology in Synthetic α-Syn Fibril-Induced Mouse Models of Synucleinopathy.Journal of neuropathology and experimental neurology, , 10-01, Volume: 78, Issue:10, 2019
miR-let-7a suppresses α-Synuclein-induced microglia inflammation through targeting STAT3 in Parkinson's disease.Biochemical and biophysical research communications, , 11-19, Volume: 519, Issue:4, 2019
Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology.Neurobiology of aging, , Volume: 83, 2019
Mutations in CHCHD2 cause α-synuclein aggregation.Human molecular genetics, , 12-01, Volume: 28, Issue:23, 2019
Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.Molecular cell, , 03-07, Volume: 73, Issue:5, 2019
Neuroprotective role of kolaviron in striatal redo-inflammation associated with rotenone model of Parkinson's disease.Neurotoxicology, , Volume: 73, 2019
Chronic nigral neuromodulation aggravates behavioral deficits and synaptic changes in an α-synuclein based rat model for Parkinson's disease.Acta neuropathologica communications, , 10-22, Volume: 7, Issue:1, 2019
IRE1 promotes neurodegeneration through autophagy-dependent neuron death in the Drosophila model of Parkinson's disease.Cell death & disease, , 10-22, Volume: 10, Issue:11, 2019
GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson's Disease.Scientific reports, , 06-10, Volume: 9, Issue:1, 2019
Dopaminergic neuron injury in Parkinson's disease is mitigated by interfering lncRNA SNHG14 expression to regulate the miR-133b/ α-synuclein pathway.Aging, , 11-04, Volume: 11, Issue:21, 2019
Hsp110 mitigates α-synuclein pathology in vivo.Proceedings of the National Academy of Sciences of the United States of America, , 11-26, Volume: 116, Issue:48, 2019
Oligodendroglial α-synucleinopathy-driven neuroinflammation in multiple system atrophy.Brain pathology (Zurich, Switzerland), , Volume: 29, Issue:3, 2019
Caffeic acid reduces A53T α-synuclein by activating JNK/Bcl-2-mediated autophagy in vitro and improves behaviour and protects dopaminergic neurons in a mouse model of Parkinson's disease.Pharmacological research, , Volume: 150, 2019
Apelin-13 protects dopaminergic neurons in MPTP-induced Parkinson's disease model mice through inhibiting endoplasmic reticulum stress and promoting autophagy.Brain research, , 07-15, Volume: 1715, 2019
Plant poisoning leads to alpha-synucleinopathy and neuromelanopathy in kangaroos.Scientific reports, , 11-13, Volume: 9, Issue:1, 2019
Small molecule modulator of aggrephagy regulates neuroinflammation to curb pathogenesis of neurodegeneration.EBioMedicine, , Volume: 50, 2019
A mouse model of adult-onset multiple system atrophy.Neurobiology of disease, , Volume: 127, 2019
Lycopodium Attenuates Loss of Dopaminergic Neurons by Suppressing Oxidative Stress and Neuroinflammation in a Rat Model of Parkinson's Disease.Molecules (Basel, Switzerland), , Jun-10, Volume: 24, Issue:11, 2019
Sex Differences in Rotenone Sensitivity Reflect the Male-to-Female Ratio in Human Parkinson's Disease Incidence.Toxicological sciences : an official journal of the Society of Toxicology, , 07-01, Volume: 170, Issue:1, 2019
Alpha-synuclein is strategically positioned for afferent modulation of midbrain dopamine neurons and is essential for cocaine preference.Communications biology, , Volume: 2, 2019
Early disease course is unaltered in mucopolysaccharidosis type IIIA (MPS IIIA) mice lacking α-synuclein.Neuropathology and applied neurobiology, , Volume: 45, Issue:7, 2019
Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease.Scientific reports, , 11-22, Volume: 9, Issue:1, 2019
The prion-like spreading of α-synuclein: From in vitro to in vivo models of Parkinson's disease.Ageing research reviews, , Volume: 50, 2019
In Vivo Protein Complementation Demonstrates Presynaptic α-Synuclein Oligomerization and Age-Dependent Accumulation of 8-16-mer Oligomer Species.Cell reports, , Nov-26, Volume: 29, Issue:9, 2019
Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a Communications biology, , Volume: 2, 2019
Neuroprotective Effect of Dichloromethane Extraction From Piper nigrum L. and Piper longum L. on Permanent Focal Cerebral Ischemia Injury in Rats.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, , Volume: 28, Issue:3, 2019
Selective inhibition of mitochondrial sodium-calcium exchanger protects striatal neurons from α-synuclein plus rotenone induced toxicity.Cell death & disease, , 01-28, Volume: 10, Issue:2, 2019
Parkinson's disease recovery by GM1 oligosaccharide treatment in the B4galnt1Scientific reports, , 12-18, Volume: 9, Issue:1, 2019
Targeting alpha synuclein and amyloid beta by a multifunctional, brain-penetrant dopamine D2/D3 agonist D-520: Potential therapeutic application in Parkinson's disease with dementia.Scientific reports, , 12-23, Volume: 9, Issue:1, 2019
Unbalanced calcium channel activity underlies selective vulnerability of nigrostriatal dopaminergic terminals in Parkinsonian mice.Scientific reports, , 03-19, Volume: 9, Issue:1, 2019
Heterogeneity in gut microbiota drive polyphenol metabolism that influences α-synuclein misfolding and toxicity.The Journal of nutritional biochemistry, , Volume: 64, 2019
Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein.Science signaling, , 03-12, Volume: 12, Issue:572, 2019
α-Synuclein Expression Is Preserved in Substantia Nigra GABAergic Fibers of Young and Aged Neurotoxin-Treated Rhesus Monkeys.Cell transplantation, , Volume: 28, Issue:4, 2019
Histamine-4 receptor antagonist JNJ7777120 inhibits pro-inflammatory microglia and prevents the progression of Parkinson-like pathology and behaviour in a rat model.Brain, behavior, and immunity, , Volume: 76, 2019
Impairment of Nrf2- and Nitrergic-Mediated Gastrointestinal Motility in an MPTP Mouse Model of Parkinson's Disease.Digestive diseases and sciences, , Volume: 64, Issue:12, 2019
MSA prions exhibit remarkable stability and resistance to inactivation.Acta neuropathologica, , Volume: 135, Issue:1, 2018
Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term.Acta neuropathologica, , Volume: 135, Issue:1, 2018
Pleiotropic neuropathological and biochemical alterations associated with Myo5a mutation in a rat Model.Brain research, , 01-15, Volume: 1679, 2018
What is the Evidence That Parkinson's Disease is a Prion Disorder, Which Originates in the Gut?International journal of molecular sciences, , Nov-12, Volume: 19, Issue:11, 2018
Deposition of Phosphorylated α-Synuclein in the rTg4510 Mouse Model of Tauopathy.Journal of neuropathology and experimental neurology, , 10-01, Volume: 77, Issue:10, 2018
Impact of DHA intake in a mouse model of synucleinopathy.Experimental neurology, , Volume: 301, Issue:Pt A, 2018
Yeast red pigment modifies cloned human α-synuclein pathogenesis in Parkinson disease models in Saccharomyces cerevisiae and Drosophila melanogaster.Neurochemistry international, , Volume: 120, 2018
Mechanical stress increases brain amyloid β, tau, and α-synuclein concentrations in wild-type mice.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 14, Issue:4, 2018
Key themes and future prospects in translational multiple system atrophy research.Autonomic neuroscience : basic & clinical, , Volume: 211, 2018
Taurine protects dopaminergic neurons in a mouse Parkinson's disease model through inhibition of microglial M1 polarization.Cell death & disease, , 04-01, Volume: 9, Issue:4, 2018
Toxic properties of microsome-associated alpha-synuclein species in mouse primary neurons.Neurobiology of disease, , Volume: 111, 2018
Gene therapy approaches in the non-human primate model of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 125, Issue:3, 2018
Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity.Acta neuropathologica communications, , 07-02, Volume: 6, Issue:1, 2018
Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson's disease.Cell death & disease, , 07-26, Volume: 9, Issue:8, 2018
Resveratrol alleviates motor and cognitive deficits and neuropathology in the A53T α-synuclein mouse model of Parkinson's disease.Food & function, , Dec-13, Volume: 9, Issue:12, 2018
MANF protects dopamine neurons and locomotion defects from a human α-synuclein induced Parkinson's disease model in C. elegans by regulating ER stress and autophagy pathways.Experimental neurology, , Volume: 308, 2018
Effects of mild running on substantia nigra during early neurodegeneration.Journal of sports sciences, , Volume: 36, Issue:12, 2018
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.ACS chemical biology, , 08-17, Volume: 13, Issue:8, 2018
α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton.Neuron, , 01-03, Volume: 97, Issue:1, 2018
Holothuria scabra extracts exhibit anti-Parkinson potential in C. elegans: A model for anti-Parkinson testing.Nutritional neuroscience, , Volume: 21, Issue:6, 2018
Dynamic footprint based locomotion sway assessment in α-synucleinopathic mice using Fast Fourier Transform and Low Pass Filter.Journal of neuroscience methods, , 02-15, Volume: 296, 2018
The Protective Role of Brain CYP2J in Parkinson's Disease Models.Oxidative medicine and cellular longevity, , Volume: 2018, 2018
Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation.Molecular neurodegeneration, , 08-09, Volume: 13, Issue:1, 2018
Osmotic stress induced toxicity exacerbates Parkinson's associated effects via dysregulation of autophagy in transgenic C. elegans model.Cellular signalling, , Volume: 45, 2018
Potential neuroprotective effect of androst-5-ene-3β, 17β-diol (ADIOL) on the striatum, and substantia nigra in Parkinson's disease rat model.Journal of cellular physiology, , Volume: 233, Issue:8, 2018
The enteric nervous system in PD: gateway, bystander victim, or source of solutions.Cell and tissue research, , Volume: 373, Issue:1, 2018
New Developments in Genetic rat models of Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:5, 2018
Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 06-19, Volume: 115, Issue:25, 2018
ELISA method to detect α-synuclein oligomers in cell and animal models.PloS one, , Volume: 13, Issue:4, 2018
Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice.Science translational medicine, , 10-31, Volume: 10, Issue:465, 2018
Translational therapies for multiple system atrophy: Bottlenecks and future directions.Autonomic neuroscience : basic & clinical, , Volume: 211, 2018
Immunization with α-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic Parkinsonism model.Glia, , Volume: 66, Issue:1, 2018
Curcumin affords neuroprotection and inhibits α-synuclein aggregation in lipopolysaccharide-induced Parkinson's disease model.Inflammopharmacology, , Volume: 26, Issue:2, 2018
Effect of optogenetic modulation on entopeduncular input affects thalamic discharge and behavior in an AAV2-α-synuclein-induced hemiparkinson rat model.Neuroscience letters, , Jan-01, Volume: 662, 2018
A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia.Acta neuropathologica communications, , 05-10, Volume: 6, Issue:1, 2018
Modulation of β-glucocerebrosidase increases α-synuclein secretion and exosome release in mouse models of Parkinson's disease.Human molecular genetics, , 05-15, Volume: 27, Issue:10, 2018
Locomotor differences in mice expressing wild-type human α-synuclein.Neurobiology of aging, , Volume: 65, 2018
Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age.Scientific reports, , 10-12, Volume: 8, Issue:1, 2018
Cx3cr1-deficiency exacerbates alpha-synuclein-A53T induced neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease.Glia, , Volume: 66, Issue:8, 2018
Genomic DNA levels of mutant alpha-synuclein correlate with non-motor symptoms in an A53T Parkinson's disease mouse model.Neurochemistry international, , Volume: 114, 2018
Exacerbation of sensorimotor dysfunction in mice deficient in Atp13a2 and overexpressing human wildtype alpha-synuclein.Behavioural brain research, , 05-02, Volume: 343, 2018
Functional Characterization of Novel Circular RNA Molecule, circzip-2 and Its Synthesizing Gene zip-2 in C. elegans Model of Parkinson's Disease.Molecular neurobiology, , Volume: 55, Issue:8, 2018
Impaired Photic Entrainment of Spontaneous Locomotor Activity in Mice Overexpressing Human Mutant α-Synuclein.International journal of molecular sciences, , Jun-03, Volume: 19, Issue:6, 2018
Effect of cabergoline alginate nanocomposite on the transgenic Drosophila melanogaster model of Parkinson's disease.Toxicology mechanisms and methods, , Volume: 28, Issue:9, 2018
Oligomer-prone E57K-mutant alpha-synuclein exacerbates integration deficit of adult hippocampal newborn neurons in transgenic mice.Brain structure & function, , Volume: 223, Issue:3, 2018
Alpha-synuclein inhibits Snx3-retromer-mediated retrograde recycling of iron transporters in S. cerevisiae and C. elegans models of Parkinson's disease.Human molecular genetics, , 05-01, Volume: 27, Issue:9, 2018
Naringenin Decreases α-Synuclein Expression and Neuroinflammation in MPTP-Induced Parkinson's Disease Model in Mice.Neurotoxicity research, , Volume: 33, Issue:3, 2018
Degradation of alpha-synuclein by dendritic cell factor 1 delays neurodegeneration and extends lifespan in Drosophila.Neurobiology of aging, , Volume: 67, 2018
DL‑3‑n‑butylphthalide reduces microglial activation in lipopolysaccharide‑induced Parkinson's disease model mice.Molecular medicine reports, , Volume: 17, Issue:3, 2018
Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson's Disease in Rodents.Journal of Parkinson's disease, , Volume: 8, Issue:2, 2018
Impaired Fast Network Oscillations and Mitochondrial Dysfunction in a Mouse Model of Alpha-synucleinopathy (A30P).Neuroscience, , 05-01, Volume: 377, 2018
Influence of Early Life Lead (Pb) Exposure on α-Synuclein, GSK-3β and Caspase-3 Mediated Tauopathy: Implications on Alzheimer's Disease.Current Alzheimer research, , Volume: 15, Issue:12, 2018
The neuropathology of multiple system atrophy and its therapeutic implications.Autonomic neuroscience : basic & clinical, , Volume: 211, 2018
Sir-2.1 mediated attenuation of α-synuclein expression by Alaskan bog blueberry polyphenols in a transgenic model of Caenorhabditis elegans.Scientific reports, , 07-05, Volume: 8, Issue:1, 2018
LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons.Acta neuropathologica communications, , 05-31, Volume: 6, Issue:1, 2018
Parkinson-Associated SNCA Enhancer Variants Revealed by Open Chromatin in Mouse Dopamine Neurons.American journal of human genetics, , 12-06, Volume: 103, Issue:6, 2018
The lysosomal membrane protein LAMP2A promotes autophagic flux and prevents SNCA-induced Parkinson disease-like symptoms in the Drosophila brain.Autophagy, , Volume: 14, Issue:11, 2018
The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson's disease.Scientific reports, , 11-01, Volume: 8, Issue:1, 2018
Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease.Behavioural brain research, , Feb-26, Volume: 339, 2018
Effects of Ginkgo Biloba Extract on A53T α-Synuclein Transgenic Mouse Models of Parkinson's Disease.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, , Volume: 45, Issue:2, 2018
Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo.Scientific reports, , 01-24, Volume: 8, Issue:1, 2018
In vivo models of alpha-synuclein transmission and propagation.Cell and tissue research, , Volume: 373, Issue:1, 2018
Early fine motor impairment and behavioral dysfunction in (Thy-1)-h[A30P] alpha-synuclein mice.Brain and behavior, , Volume: 8, Issue:3, 2018
Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease.Neuron, , 10-10, Volume: 100, Issue:1, 2018
2-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease.Molecular neurobiology, , Volume: 55, Issue:12, 2018
Propagation of alpha-synuclein pathology from the olfactory bulb: possible role in the pathogenesis of dementia with Lewy bodies.Cell and tissue research, , Volume: 373, Issue:1, 2018
Suppression of autophagy in the brain of transgenic mice with overexpression of А53Т-mutant α-synuclein as an early event at synucleinopathy progression.Neuroscience letters, , 04-13, Volume: 672, 2018
The use of nonhuman primate models to understand processes in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 125, Issue:3, 2018
Angiotensin Type 1 Receptor Antagonists Protect Against Alpha-Synuclein-Induced Neuroinflammation and Dopaminergic Neuron Death.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 15, Issue:4, 2018
Distinct functional roles of Vps41-mediated neuroprotection in Alzheimer's and Parkinson's disease models of neurodegeneration.Human molecular genetics, , 12-15, Volume: 27, Issue:24, 2018
"Cell-addictive" dual-target traceable nanodrug for Parkinson's disease treatment via flotillins pathway.Theranostics, , Volume: 8, Issue:19, 2018
α-Synuclein disrupts the anti-inflammatory role of Drd2 via interfering β-arrestin2-TAB1 interaction in astrocytes.Journal of neuroinflammation, , Sep-10, Volume: 15, Issue:1, 2018
Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice.Proceedings of the National Academy of Sciences of the United States of America, , 02-13, Volume: 115, Issue:7, 2018
Sequestration of synaptic proteins by alpha-synuclein aggregates leading to neurotoxicity is inhibited by small peptide.PloS one, , Volume: 13, Issue:4, 2018
α-synuclein expression from a single copy transgene increases sensitivity to stress and accelerates neuronal loss in genetic models of Parkinson's disease.Experimental neurology, , Volume: 310, 2018
Modeling Parkinson's Disease in C. elegans.Journal of Parkinson's disease, , Volume: 8, Issue:1, 2018
α-Synuclein nonhuman primate models of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 125, Issue:3, 2018
Intestinal Pathology and Gut Microbiota Alterations in a Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Mouse Model of Parkinson's Disease.Neurochemical research, , Volume: 43, Issue:10, 2018
Effects of Novel Calpain Inhibitors in Transgenic Animal Model of Parkinson's disease/dementia with Lewy bodies.Scientific reports, , 12-27, Volume: 8, Issue:1, 2018
Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson's disease and DLB.Proceedings of the National Academy of Sciences of the United States of America, , 12-18, Volume: 115, Issue:51, 2018
Effect of capsaicin on the oxidative stress and dopamine content in the transgenic Drosophila model of Parkinson's disease.Acta biologica Hungarica, , Volume: 69, Issue:2, 2018
Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson's disease.Journal of neuroinflammation, , Aug-30, Volume: 15, Issue:1, 2018
Decreased expression of serum- and glucocorticoid-inducible kinase 1 (SGK1) promotes alpha-synuclein increase related with down-regulation of dopaminergic cell in the Substantia Nigra of chronic MPTP-induced Parkinsonism mice and in SH-SY5Y cells.Gene, , Jun-30, Volume: 661, 2018
Endogenous Murine Amyloid-β Peptide Assembles into Aggregates in the Aged C57BL/6J Mouse Suggesting These Animals as a Model to Study Pathogenesis of Amyloid-β Plaque Formation.Journal of Alzheimer's disease : JAD, , Volume: 61, Issue:4, 2018
Ceftriaxone Treatment for Neuronal Deficits: A Histological and MEMRI Study in a Rat Model of Dementia with Lewy Bodies.Behavioural neurology, , Volume: 2018, 2018
Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease.Nature medicine, , Volume: 24, Issue:7, 2018
Investigating the neuroprotective effect of AAV-mediated β-synuclein overexpression in a transgenic model of synucleinopathy.Scientific reports, , 12-03, Volume: 8, Issue:1, 2018
Intranasal carnosine attenuates transcriptomic alterations and improves mitochondrial function in the Thy1-aSyn mouse model of Parkinson's disease.Molecular genetics and metabolism, , Volume: 125, Issue:3, 2018
α-Synuclein: Multiple System Atrophy Prions.Cold Spring Harbor perspectives in medicine, , 07-02, Volume: 8, Issue:7, 2018
α-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's disease.The EMBO journal, , 06-15, Volume: 37, Issue:12, 2018
Cerebral inoculation of human A53T α-synuclein reduces spatial memory decline and amyloid-β aggregation in APP/PS1 transgenic mice of Alzheimer's disease.Brain research bulletin, , Volume: 143, 2018
Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease.Acta neuropathologica, , Volume: 136, Issue:6, 2018
Cre-dependent AAV vectors for highly targeted expression of disease-related proteins and neurodegeneration in the substantia nigra.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 32, Issue:8, 2018
BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT.JCI insight, , 08-23, Volume: 3, Issue:16, 2018
The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson's disease mouse model.Human molecular genetics, , 07-01, Volume: 27, Issue:13, 2018
Neuroprotective effects of voluntary running on cognitive dysfunction in an α-synuclein rat model of Parkinson's disease.Neurobiology of aging, , Volume: 65, 2018
α-Synuclein interacts directly but reversibly with psychosine: implications for α-synucleinopathies.Scientific reports, , 08-20, Volume: 8, Issue:1, 2018
Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson's disease.Cell death & disease, , 06-13, Volume: 9, Issue:6, 2018
CRISPR/Cas9-Mediated Generation of Guangxi Bama Minipigs Harboring Three Mutations in α-Synuclein Causing Parkinson's Disease.Scientific reports, , 08-20, Volume: 8, Issue:1, 2018
In Silico, in Vitro, and in Vivo Evaluation of New Candidates for α-Synuclein PET Imaging.Molecular pharmaceutics, , 08-06, Volume: 15, Issue:8, 2018
Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in α-Synuclein Aggregation Disorders.EBioMedicine, , Volume: 31, 2018
The Challenge of the Pathogenesis of Parkinson's Disease: Is Autoimmunity the Culprit?Frontiers in immunology, , Volume: 9, 2018
Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease.Acta neuropathologica communications, , 07-05, Volume: 6, Issue:1, 2018
Progressive striatonigral degeneration in a transgenic mouse model of multiple system atrophy: translational implications for interventional therapies.Acta neuropathologica communications, , 01-03, Volume: 6, Issue:1, 2018
Long-lasting pathological consequences of overexpression-induced α-synuclein spreading in the rat brain.Aging cell, , Volume: 17, Issue:2, 2018
Integrated analysis of genetic, behavioral, and biochemical data implicates neural stem cell-induced changes in immunity, neurotransmission and mitochondrial function in Dementia with Lewy Body mice.Acta neuropathologica communications, , 03-10, Volume: 5, Issue:1, 2017
In utero delivery of rAAV2/9 induces neuronal expression of the transgene in the brain: towards new models of Parkinson's disease.Gene therapy, , Volume: 24, Issue:12, 2017
Early start of progressive motor deficits in Line 61 α-synuclein transgenic mice.BMC neuroscience, , 01-31, Volume: 18, Issue:1, 2017
FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome.Proceedings of the National Academy of Sciences of the United States of America, , 12-26, Volume: 114, Issue:52, 2017
Effects of small-molecule amyloid modulators on a Drosophila model of Parkinson's disease.PloS one, , Volume: 12, Issue:9, 2017
AAV-PHP.B-Mediated Global-Scale Expression in the Mouse Nervous System Enables GBA1 Gene Therapy for Wide Protection from Synucleinopathy.Molecular therapy : the journal of the American Society of Gene Therapy, , Dec-06, Volume: 25, Issue:12, 2017
Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease.Science (New York, N.Y.), , 09-22, Volume: 357, Issue:6357, 2017
Evaluation of a DNA Aβ42 Vaccine in Aged NZW Rabbits: Antibody Kinetics and Immune Profile after Intradermal Immunization with Full-Length DNA Aβ42 Trimer.Journal of Alzheimer's disease : JAD, , Volume: 57, Issue:1, 2017
Modeling Parkinson's disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain.Proceedings of the National Academy of Sciences of the United States of America, , 09-26, Volume: 114, Issue:39, 2017
Protein arginylation targets alpha synuclein, facilitates normal brain health, and prevents neurodegeneration.Scientific reports, , 09-12, Volume: 7, Issue:1, 2017
A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies.PloS one, , Volume: 12, Issue:9, 2017
Age-Dependent Alpha-Synuclein Accumulation and Phosphorylation in the Enteric Nervous System in a Transgenic Mouse Model of Parkinson's Disease.Neuroscience bulletin, , Volume: 33, Issue:5, 2017
NCEH-1 modulates cholesterol metabolism and protects against α-synuclein toxicity in a C. elegans model of Parkinson's disease.Human molecular genetics, , 10-01, Volume: 26, Issue:19, 2017
EGCG-mediated Protection of the Membrane Disruption and Cytotoxicity Caused by the 'Active Oligomer' of α-Synuclein.Scientific reports, , 12-20, Volume: 7, Issue:1, 2017
Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases.EMBO molecular medicine, , Volume: 9, Issue:1, 2017
Running wheel exercise reduces α-synuclein aggregation and improves motor and cognitive function in a transgenic mouse model of Parkinson's disease.PloS one, , Volume: 12, Issue:12, 2017
Reduced TH expression and α-synuclein accumulation contribute towards nigrostriatal dysfunction in experimental hepatic encephalopathy.Restorative neurology and neuroscience, , Volume: 35, Issue:5, 2017
Sirtuins as modifiers of Parkinson's disease pathology.Journal of neuroscience research, , Volume: 95, Issue:4, 2017
Therapeutic approaches to target alpha-synuclein pathology.Experimental neurology, , Volume: 298, Issue:Pt B, 2017
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.PLoS biology, , Volume: 15, Issue:3, 2017
Hederagenin and α-hederin promote degradation of proteins in neurodegenerative diseases and improve motor deficits in MPTP-mice.Pharmacological research, , Volume: 115, 2017
Mulberry fruit ameliorates Parkinson's-disease-related pathology by reducing α-synuclein and ubiquitin levels in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model.The Journal of nutritional biochemistry, , Volume: 39, 2017
CCAAT/Enhancer binding protein β silencing mitigates glial activation and neurodegeneration in a rat model of Parkinson's disease.Scientific reports, , 10-19, Volume: 7, Issue:1, 2017
Interaction between subclinical doses of the Parkinson's disease associated gene, α-synuclein, and the pesticide, rotenone, precipitates motor dysfunction and nigrostriatal neurodegeneration in rats.Behavioural brain research, , 01-01, Volume: 316, 2017
Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles.Scientific reports, , 11-08, Volume: 7, Issue:1, 2017
Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease.Proceedings of the National Academy of Sciences of the United States of America, , 03-14, Volume: 114, Issue:11, 2017
Effects of Alpha-Synuclein on Primary Spinal Cord Neurons Associated with Apoptosis and CNTF Expression.Cellular and molecular neurobiology, , Volume: 37, Issue:5, 2017
Bilateral upregulation of α-synuclein expression in the mouse substantia nigra by intracranial rotenone treatment.Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, , Volume: 69, Issue:2, 2017
Anti-Parkinsonian effects of β-amyrin are regulated via LGG-1 involved autophagy pathway in Caenorhabditis elegans.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Dec-01, Volume: 36, 2017
α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration.Acta neuropathologica communications, , Nov-21, Volume: 5, Issue:1, 2017
Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy.Acta neuropathologica communications, , 01-13, Volume: 5, Issue:1, 2017
Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models.Proceedings of the National Academy of Sciences of the United States of America, , 03-07, Volume: 114, Issue:10, 2017
Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain.Acta neuropathologica communications, , 06-23, Volume: 5, Issue:1, 2017
MicroRNA expressing profiles in A53T mutant alpha-synuclein transgenic mice and Parkinsonian.Oncotarget, , Jan-03, Volume: 8, Issue:1, 2017
Inhibition by Multifunctional Magnetic Nanoparticles Loaded with Alpha-Synuclein RNAi Plasmid in a Parkinson's Disease Model.Theranostics, , Volume: 7, Issue:2, 2017
Nurr1 overexpression exerts neuroprotective and anti-inflammatory roles via down-regulating CCL2 expression in both in vivo and in vitro Parkinson's disease models.Biochemical and biophysical research communications, , Jan-22, Volume: 482, Issue:4, 2017
A preclinical screen to evaluate pharmacotherapies for the treatment of agitation in dementia.Behavioural pharmacology, , Volume: 28, Issue:2 and 3-Sp, 2017
Comparison of independent screens on differentially vulnerable motor neurons reveals alpha-synuclein as a common modifier in motor neuron diseases.PLoS genetics, , Volume: 13, Issue:3, 2017
Motor deficits and beta oscillations are dissociable in an alpha-synuclein model of Parkinson's disease.The European journal of neuroscience, , Volume: 46, Issue:3, 2017
Lack of spontaneous age-related brain pathology in Octodon degus: a reappraisal of the model.Scientific reports, , 04-04, Volume: 7, 2017
The FBXO7 homologue nutcracker and binding partner PI31 in Drosophila melanogaster models of Parkinson's disease.Genome, , Volume: 60, Issue:1, 2017
Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.Brain : a journal of neurology, , May-01, Volume: 140, Issue:5, 2017
Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing.Genome biology, , 01-30, Volume: 18, Issue:1, 2017
Acrolein acts as a neurotoxin in the nigrostriatal dopaminergic system of rat: involvement of α-synuclein aggregation and programmed cell death.Scientific reports, , 04-12, Volume: 7, 2017
Early and progressive microstructural brain changes in mice overexpressing human α-Synuclein detected by diffusion kurtosis imaging.Brain, behavior, and immunity, , Volume: 61, 2017
Derivation of mouse embryonic stem cell lines from tyrosine hydroxylase reporter mice crossed with a human SNCA transgenic mouse model of Parkinson's disease.Stem cell research, , Volume: 19, 2017
The Transcellular Propagation and Intracellular Trafficking of α-Synuclein.Cold Spring Harbor perspectives in medicine, , Sep-01, Volume: 7, Issue:9, 2017
Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice.Molecular neurodegeneration, , 01-03, Volume: 12, Issue:1, 2017
Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.Neurochemistry international, , Volume: 109, 2017
Subthalamic nucleus deep brain stimulation is neuroprotective in the A53T α-synuclein Parkinson's disease rat model.Annals of neurology, , Volume: 81, Issue:6, 2017
Expression signatures of long non-coding RNA in the substantia nigra of pre-symptomatic mouse model of Parkinson's disease.Behavioural brain research, , 07-28, Volume: 331, 2017
Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy.Neurobiology of disease, , Volume: 104, 2017
Holocranohistochemistry enables the visualization of α-synuclein expression in the murine olfactory system and discovery of its systemic anti-microbial effects.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 124, Issue:6, 2017
Higher levels of myelin phospholipids in brains of neuronal α-Synuclein transgenic mice precede myelin loss.Acta neuropathologica communications, , 05-08, Volume: 5, Issue:1, 2017
Cellular models as tools for the study of the role of alpha-synuclein in Parkinson's disease.Experimental neurology, , Volume: 298, Issue:Pt B, 2017
Treadmill exercise produces neuroprotective effects in a murine model of Parkinson's disease by regulating the TLR2/MyD88/NF-κB signaling pathway.Neuroscience, , 07-25, Volume: 356, 2017
Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits.Proceedings of the National Academy of Sciences of the United States of America, , 06-06, Volume: 114, Issue:23, 2017
Viral-mediated oligodendroglial alpha-synuclein expression models multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:8, 2017
Cystatin C as a potential therapeutic mediator against Parkinson's disease via VEGF-induced angiogenesis and enhanced neuronal autophagy in neurovascular units.Cell death & disease, , 06-01, Volume: 8, Issue:6, 2017
Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy.Acta neuropathologica communications, , 01-05, Volume: 5, Issue:1, 2017
α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration.Neurobiology of disease, , Volume: 105, 2017
Spinal cord stimulation improves forelimb use in an alpha-synuclein animal model of Parkinson's disease.The International journal of neuroscience, , Volume: 127, Issue:1, 2017
A loss of Pdxk model of Parkinson disease in Drosophila can be suppressed by Buffy.BMC research notes, , Jun-12, Volume: 10, Issue:1, 2017
Lithium increases hippocampal SNARE protein abundance after traumatic brain injury.Experimental neurology, , Volume: 289, 2017
Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates.Acta neuropathologica communications, , 06-16, Volume: 5, Issue:1, 2017
Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils.Journal of virology, , Jan-15, Volume: 91, Issue:2, 2017
Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson's disease.Scientific reports, , 06-20, Volume: 7, Issue:1, 2017
Reassessment of subacute MPTP-treated mice as animal model of Parkinson's disease.Acta pharmacologica Sinica, , Volume: 38, Issue:10, 2017
Treadmill exercise alleviates motor deficits and improves mitochondrial import machinery in an MPTP-induced mouse model of Parkinson's disease.Experimental gerontology, , Volume: 89, 2017
Human cyclophilin 40 unravels neurotoxic amyloids.PLoS biology, , Volume: 15, Issue:6, 2017
D-Ala2-GIP-glu-PAL is neuroprotective in a chronic Parkinson's disease mouse model and increases BNDF expression while reducing neuroinflammation and lipid peroxidation.European journal of pharmacology, , Feb-15, Volume: 797, 2017
Brain infusion of α-synuclein oligomers induces motor and non-motor Parkinson's disease-like symptoms in mice.Behavioural brain research, , 08-30, Volume: 333, 2017
Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease.Nature structural & molecular biology, , Volume: 24, Issue:8, 2017
Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy.Molecular neurodegeneration, , 07-04, Volume: 12, Issue:1, 2017
Imaging neuroinflammation to monitor α-synucleinopathy.The Lancet. Neurology, , Volume: 16, Issue:10, 2017
The Cleavage Effect of Mesenchymal Stem Cell and Its Derived Matrix Metalloproteinase-2 on Extracellular α-Synuclein Aggregates in Parkinsonian Models.Stem cells translational medicine, , Volume: 6, Issue:3, 2017
Decelerated neurodegeneration after intravitreal injection of α-synuclein antibodies in a glaucoma animal model.Scientific reports, , 07-24, Volume: 7, Issue:1, 2017
Early synaptic dysfunction induced by α-synuclein in a rat model of Parkinson's disease.Scientific reports, , 07-25, Volume: 7, Issue:1, 2017
Animal models of α-synucleinopathy for Parkinson disease drug development.Nature reviews. Neuroscience, , Volume: 18, Issue:9, 2017
Experimental animal models of Parkinson's disease: A transition from assessing symptomatology to α-synuclein targeted disease modification.Experimental neurology, , Volume: 298, Issue:Pt B, 2017
Lysosomal dysfunction in the brain of a mouse model with intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein.Molecular psychiatry, , Volume: 22, Issue:7, 2017
Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation.Journal of neuroinflammation, , 08-02, Volume: 14, Issue:1, 2017
Novel animal model defines genetic contributions for neuron-to-neuron transfer of α-synuclein.Scientific reports, , 08-08, Volume: 7, Issue:1, 2017
Alterations in Activity-Dependent Neuroprotective Protein in Sporadic and Experimental Parkinson's Disease.Journal of Parkinson's disease, , Volume: 6, Issue:1, 2016
How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease?Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease.Acta neuropathologica communications, , 06-23, Volume: 4, Issue:1, 2016
Acteoside Binds to Caspase-3 and Exerts Neuroprotection in the Rotenone Rat Model of Parkinson's Disease.PloS one, , Volume: 11, Issue:9, 2016
Anxiolytic and neuroprotective effects of the Traditional Chinese Medicinal formulation Dan-zhi-xiao-yao-san in a rat model of chronic stress.Molecular medicine reports, , Volume: 14, Issue:2, 2016
Inhibition of Atg6 and Pi3K59F autophagy genes in neurons decreases lifespan and locomotor ability in Drosophila melanogaster.Genetics and molecular research : GMR, , Oct-24, Volume: 15, Issue:4, 2016
Resveratrol alleviates MPTP-induced motor impairments and pathological changes by autophagic degradation of α-synuclein via SIRT1-deacetylated LC3.Molecular nutrition & food research, , Volume: 60, Issue:10, 2016
Acrylamide induces locomotor defects and degeneration of dopamine neurons in Caenorhabditis elegans.Journal of applied toxicology : JAT, , Volume: 36, Issue:1, 2016
α-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy.Acta neuropathologica, , Volume: 132, Issue:1, 2016
Formation and Implications of Alpha-Synuclein Radical in Maneb- and Paraquat-Induced Models of Parkinson's Disease.Molecular neurobiology, , Volume: 53, Issue:5, 2016
7,8-dihydroxyflavone Ameliorates Motor Deficits Via Suppressing α-synuclein Expression and Oxidative Stress in the MPTP-induced Mouse Model of Parkinson's Disease.CNS neuroscience & therapeutics, , Volume: 22, Issue:7, 2016
Beta-asarone protects against MPTP-induced Parkinson's disease via regulating long non-coding RNA MALAT1 and inhibiting α-synuclein protein expression.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 83, 2016
Cellular models for Parkinson's disease.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Treatment with Trehalose Prevents Behavioral and Neurochemical Deficits Produced in an AAV α-Synuclein Rat Model of Parkinson's Disease.Molecular neurobiology, , Volume: 53, Issue:4, 2016
Pedunculopontine cell loss and protein aggregation direct microglia activation in parkinsonian rats.Brain structure & function, , Volume: 221, Issue:4, 2016
Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease.Acta neuropathologica communications, , Apr-22, Volume: 4, 2016
Aggregated α-Synuclein Increases SOD1 Oligomerization in a Mouse Model of Amyotrophic Lateral Sclerosis.The American journal of pathology, , Volume: 186, Issue:8, 2016
Thiol Oxidation by Diamide Leads to Dopaminergic Degeneration and Parkinsonism Phenotype in Mice: A Model for Parkinson's Disease.Antioxidants & redox signaling, , 08-10, Volume: 25, Issue:5, 2016
Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson's disease.Human molecular genetics, , 07-01, Volume: 25, Issue:13, 2016
Novel Epigenetic Regulation of Alpha-Synuclein Expression in Down Syndrome.Molecular neurobiology, , Volume: 53, Issue:1, 2016
Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy.Proceedings of the National Academy of Sciences of the United States of America, , 08-23, Volume: 113, Issue:34, 2016
Clioquinol Improves Cognitive, Motor Function, and Microanatomy of the Alpha-Synuclein hA53T Transgenic Mice.ACS chemical neuroscience, , Jan-20, Volume: 7, Issue:1, 2016
Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson's disease.The Journal of experimental medicine, , 08-22, Volume: 213, Issue:9, 2016
Poststroke Induction of α-Synuclein Mediates Ischemic Brain Damage.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 06-29, Volume: 36, Issue:26, 2016
Dopaminergic lesioning impairs adult hippocampal neurogenesis by distinct modification of α-synuclein.Journal of neuroscience research, , Volume: 94, Issue:1, 2016
Loss of PINK1 inhibits apoptosis by upregulating α-synuclein in inflammation-sensitized hypoxic-ischemic injury in the immature brains.Brain research, , 12-15, Volume: 1653, 2016
Chemical Compensation of Mitochondrial Phospholipid Depletion in Yeast and Animal Models of Parkinson's Disease.PloS one, , Volume: 11, Issue:10, 2016
Bee venom phospholipase A2 ameliorates motor dysfunction and modulates microglia activation in Parkinson's disease alpha-synuclein transgenic mice.Experimental & molecular medicine, , 07-08, Volume: 48, Issue:7, 2016
Transmission of α-synucleinopathy from olfactory structures deep into the temporal lobe.Molecular neurodegeneration, , 06-30, Volume: 11, Issue:1, 2016
Geniposide reduces α-synuclein by blocking microRNA-21/lysosome-associated membrane protein 2A interaction in Parkinson disease models.Brain research, , 08-01, Volume: 1644, 2016
Alpha-Synuclein Produces Early Behavioral Alterations via Striatal Cholinergic Synaptic Dysfunction by Interacting With GluN2D N-Methyl-D-Aspartate Receptor Subunit.Biological psychiatry, , Mar-01, Volume: 79, Issue:5, 2016
Up-regulation of activating transcription factor 4 induces severe loss of dopamine nigral neurons in a rat model of Parkinson's disease.Neuroscience letters, , 08-03, Volume: 627, 2016
Quantitative evaluation of orofacial motor function in mice: The pasta gnawing test, a voluntary and stress-free behavior test.Journal of neuroscience methods, , 12-01, Volume: 274, 2016
Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function.Autophagy, , 10-02, Volume: 12, Issue:10, 2016
Mesenchymal stem cells enhance α-synuclein clearance via M2 microglia polarization in experimental and human parkinsonian disorder.Acta neuropathologica, , Volume: 132, Issue:5, 2016
Apocyanin, NADPH oxidase inhibitor prevents lipopolysaccharide induced α-synuclein aggregation and ameliorates motor function deficits in rats: Possible role of biochemical and inflammatory alterations.Behavioural brain research, , Jan-01, Volume: 296, 2016
Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease.PloS one, , Volume: 11, Issue:8, 2016
Identification of a specific α-synuclein peptide (α-Syn 29-40) capable of eliciting microglial superoxide production to damage dopaminergic neurons.Journal of neuroinflammation, , 06-21, Volume: 13, Issue:1, 2016
Neuroprotection by Epigenetic Modulation in a Transgenic Model of Multiple System Atrophy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 13, Issue:4, 2016
Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration.The Journal of clinical investigation, , 08-01, Volume: 126, Issue:8, 2016
Review: Spreading the word: precise animal models and validated methods are vital when evaluating prion-like behaviour of alpha-synuclein.Neuropathology and applied neurobiology, , Volume: 42, Issue:1, 2016
Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice.Annals of neurology, , Volume: 80, Issue:5, 2016
Development of Nonviral Vectors Targeting the Brain as a Therapeutic Approach For Parkinson's Disease and Other Brain Disorders.Molecular therapy : the journal of the American Society of Gene Therapy, , Volume: 24, Issue:4, 2016
Development of Passive Immunotherapies for Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Alpha-synuclein propagation: New insights from animal models.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model by targeting α-synuclein abnormalities in the substantia nigra.Toxicology letters, , Jan-22, Volume: 243, 2016
Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease.Science translational medicine, , 12-07, Volume: 8, Issue:368, 2016
Aged Lewis rats exposed to low and moderate doses of rotenone are a good model for studying the process of protein aggregation and its effects upon central nervous system cell physiology.Arquivos de neuro-psiquiatria, , Volume: 74, Issue:9, 2016
α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.Human molecular genetics, , Mar-15, Volume: 25, Issue:6, 2016
Synphilin-1 attenuates mutant LRRK2-induced neurodegeneration in Parkinson's disease models.Human molecular genetics, , Feb-15, Volume: 25, Issue:4, 2016
Dynamic Changes in Striatal mGluR1 But Not mGluR5 during Pathological Progression of Parkinson's Disease in Human Alpha-Synuclein A53T Transgenic Rats: A Multi-PET Imaging Study.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jan-13, Volume: 36, Issue:2, 2016
Differential interaction between iron and mutant alpha-synuclein causes distinctive Parkinsonian phenotypes in Drosophila.Biochimica et biophysica acta, , Volume: 1862, Issue:4, 2016
A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease.Brain : a journal of neurology, , Volume: 139, Issue:Pt 12, 2016
α-Synuclein: Experimental Pathology.Cold Spring Harbor perspectives in medicine, , Sep-01, Volume: 6, Issue:9, 2016
Aberrant adenosine A2A receptor signaling contributes to neurodegeneration and cognitive impairments in a mouse model of synucleinopathy.Experimental neurology, , Volume: 283, Issue:Pt A, 2016
Acupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain.Scientific reports, , Jan-21, Volume: 6, 2016
The role of NUB1 in α-synuclein degradation in Lewy body disease model mice.Biochemical and biophysical research communications, , Feb-12, Volume: 470, Issue:3, 2016
Inhibition of alpha-synuclein aggregation by multifunctional dopamine agonists assessed by a novel in vitro assay and an in vivo Drosophila synucleinopathy model.Scientific reports, , 12-05, Volume: 6, 2016
From the Cover: Alterations in Optineurin Expression and Localization in Pre-clinical Parkinson's Disease Models.Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 153, Issue:2, 2016
Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , Feb-16, Volume: 113, Issue:7, 2016
Progression of Behavioral and CNS Deficits in a Viable Murine Model of Chronic Neuronopathic Gaucher Disease.PloS one, , Volume: 11, Issue:9, 2016
Animal modeling an oligodendrogliopathy--multiple system atrophy.Acta neuropathologica communications, , Feb-09, Volume: 4, 2016
Microwave fields have little effect on α-synuclein aggregation in a Caenorhabditis elegans model of Parkinson's disease.Bioelectromagnetics, , Volume: 37, Issue:2, 2016
The novel adaptive rotating beam test unmasks sensorimotor impairments in a transgenic mouse model of Parkinson's disease.Behavioural brain research, , May-01, Volume: 304, 2016
Longitudinal live imaging of retinal α-synuclein::GFP deposits in a transgenic mouse model of Parkinson's Disease/Dementia with Lewy Bodies.Scientific reports, , 07-08, Volume: 6, 2016
Neuroprotective Effects of A Standardized Flavonoid Extract of Safflower Against Neurotoxin-Induced Cellular and Animal Models of Parkinson's Disease.Scientific reports, , Feb-24, Volume: 6, 2016
microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-24, Volume: 36, Issue:8, 2016
BPOZ-2 Gene Delivery Ameliorates Alpha-Synucleinopathy in A53T Transgenic Mouse Model of Parkinson's Disease.Scientific reports, , Feb-26, Volume: 6, 2016
An Overview on the Role of α -Synuclein in Experimental Models of Parkinson's Disease from Pathogenesis to Therapeutics.CNS & neurological disorders drug targets, , Volume: 15, Issue:10, 2016
Review: Novel treatment strategies targeting alpha-synuclein in multiple system atrophy as a model of synucleinopathy.Neuropathology and applied neurobiology, , Volume: 42, Issue:1, 2016
α-Synuclein-Based Animal Models of Parkinson's Disease: Challenges and Opportunities in a New Era.Trends in neurosciences, , Volume: 39, Issue:11, 2016
Changes in the miRNA-mRNA Regulatory Network Precede Motor Symptoms in a Mouse Model of Multiple System Atrophy: Clinical Implications.PloS one, , Volume: 11, Issue:3, 2016
Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector.Journal of visualized experiments : JoVE, , Feb-28, Issue:108, 2016
Hippocampal α-synuclein and interneurons in Parkinson's disease: Data from human and mouse models.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:7, 2016
Towards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parkinson's Disease: Optimization of AAV1/2 Delivery Parameters to Drive Sustained Expression of Alpha Synuclein and Dopaminergic Degeneration in Macaque.PloS one, , Volume: 11, Issue:11, 2016
α-Synuclein deficiency promotes neuroinflammation by increasing Th1 cell-mediated immune responses.Journal of neuroinflammation, , 08-26, Volume: 13, Issue:1, 2016
TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau.eLife, , 10-25, Volume: 5, 2016
FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease.Neurobiology of aging, , Volume: 36, Issue:3, 2015
Multiple system atrophy: the application of genetics in understanding etiology.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 25, Issue:1, 2015
Flies with Parkinson's disease.Experimental neurology, , Volume: 274, Issue:Pt A, 2015
Evaluation of an α synuclein sensitized dendritic cell based vaccine in a transgenic mouse model of Parkinson disease.Human vaccines & immunotherapeutics, , Volume: 11, Issue:4, 2015
Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease.Neurobiology of disease, , Volume: 77, 2015
Progressive aggregation of alpha-synuclein and selective degeneration of lewy inclusion-bearing neurons in a mouse model of parkinsonism.Cell reports, , Mar-03, Volume: 10, Issue:8, 2015
Putative neuropathological interactions in MSA: focus in the rostral ventrolateral medulla.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 25, Issue:1, 2015
Attenuation of neuromotor deficits by natural antioxidants of Decalepis hamiltonii in transgenic Drosophila model of Parkinson's disease.Neuroscience, , May-07, Volume: 293, 2015
Diffusion Kurtosis Imaging Detects Microstructural Alterations in Brain of α-Synuclein Overexpressing Transgenic Mouse Model of Parkinson's Disease: A Pilot Study.Neurotoxicity research, , Volume: 28, Issue:4, 2015
Novel therapeutic approaches in multiple system atrophy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 25, Issue:1, 2015
Viable neuronopathic Gaucher disease model in Medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein.PLoS genetics, , Volume: 11, Issue:4, 2015
Linking microtubules to Parkinson's disease: the case of parkin.Biochemical Society transactions, , Volume: 43, Issue:2, 2015
Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury.Acta neuropathologica communications, , Mar-24, Volume: 3, 2015
α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Apr-08, Volume: 35, Issue:14, 2015
The loss of glucose-regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein (α-syn) toxicity to rat nigral neurons.Neurobiology of aging, , Volume: 36, Issue:6, 2015
Neuroprotective effects of the cultivated Chondrus crispus in a C. elegans model of Parkinson's disease.Marine drugs, , Apr-14, Volume: 13, Issue:4, 2015
Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy.Molecular neurodegeneration, , Mar-19, Volume: 10, 2015
Targeted Overexpression of α-Synuclein by rAAV2/1 Vectors Induces Progressive Nigrostriatal Degeneration and Increases Vulnerability to MPTP in Mouse.PloS one, , Volume: 10, Issue:6, 2015
Role of α-synuclein in cognitive dysfunction: Studies in Drosophila melanogaster.Molecular medicine reports, , Volume: 12, Issue:2, 2015
Influence of Lentiviral β-Synuclein Overexpression in the Hippocampus of a Transgenic Mouse Model of Alzheimer's Disease on Amyloid Precursor Protein Metabolism and Pathology.Neuro-degenerative diseases, , Volume: 15, Issue:4, 2015
Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease.Journal of neuroinflammation, , May-14, Volume: 12, 2015
Fractalkine Signaling Regulates the Inflammatory Response in an α-Synuclein Model of Parkinson Disease.PloS one, , Volume: 10, Issue:10, 2015
Behavioural deficits in transgenic mice expressing human truncated (1-120 amino acid) alpha-synuclein.Experimental neurology, , Volume: 264, 2015
α-Synuclein modifies mutant huntingtin aggregation and neurotoxicity in Drosophila.Human molecular genetics, , Apr-01, Volume: 24, Issue:7, 2015
α-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson's disease occurs independent of ATP13A2 (PARK9).Neurobiology of disease, , Volume: 73, 2015
Neuroinflammation in Lewy body dementia.Parkinsonism & related disorders, , Volume: 21, Issue:12, 2015
Neural stem cells in Parkinson's disease: a role for neurogenesis defects in onset and progression.Cellular and molecular life sciences : CMLS, , Volume: 72, Issue:4, 2015
Involvement of Peripheral Nerves in the Transgenic PLP-α-Syn Model of Multiple System Atrophy: Extending the Phenotype.PloS one, , Volume: 10, Issue:10, 2015
The Parkinson's disease-related protein DJ-1 protects dopaminergic neurons in vivo and cultured cells from alpha-synuclein and 6-hydroxydopamine toxicity.Neuro-degenerative diseases, , Volume: 15, Issue:1, 2015
Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson's Disease-like Dementia.Cell, , Oct-08, Volume: 163, Issue:2, 2015
Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration.Neurobiology of disease, , Volume: 82, 2015
Early Parkinson's disease symptoms in α-synuclein transgenic monkeys.Human molecular genetics, , Apr-15, Volume: 24, Issue:8, 2015
Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization.Annals of neurology, , Volume: 77, Issue:1, 2015
The Progressive BSSG Rat Model of Parkinson's: Recapitulating Multiple Key Features of the Human Disease.PloS one, , Volume: 10, Issue:10, 2015
Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease.Human molecular genetics, , Mar-01, Volume: 24, Issue:5, 2015
Animal models of multiple system atrophy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 25, Issue:1, 2015
Social Cognition Impairments in Mice Overexpressing Alpha-Synuclein Under the Thy1 Promoter, a Model of Pre-manifest Parkinson's Disease.Journal of Parkinson's disease, , Volume: 5, Issue:3, 2015
Enduring deficits in memory and neuronal pathology after blast-induced traumatic brain injury.Scientific reports, , Nov-05, Volume: 5, 2015
Viral vector-based models of Parkinson's disease.Current topics in behavioral neurosciences, , Volume: 22, 2015
Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors.Neurobiology of aging, , Volume: 36, Issue:3, 2015
A Genetic Mouse Model of Parkinson's Disease Shows Involuntary Movements and Increased Postsynaptic Sensitivity to Apomorphine.Molecular neurobiology, , Volume: 52, Issue:3, 2015
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.PloS one, , Volume: 10, Issue:1, 2015
A53T human α-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jan-21, Volume: 35, Issue:3, 2015
Transmission of Soluble and Insoluble α-Synuclein to Mice.Journal of neuropathology and experimental neurology, , Volume: 74, Issue:12, 2015
A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy.Molecular neurodegeneration, , Sep-23, Volume: 10, 2015
Tianma Gouteng Yin, a Traditional Chinese Medicine decoction, exerts neuroprotective effects in animal and cellular models of Parkinson's disease.Scientific reports, , Nov-18, Volume: 5, 2015
Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons.Neurobiology of disease, , Volume: 82, 2015
Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression.Human molecular genetics, , Feb-15, Volume: 24, Issue:4, 2015
Parkinson's disease, anxious depression and serotonin--zooming in on hippocampal neurogenesis.Journal of neurochemistry, , Volume: 135, Issue:3, 2015
Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death.Human molecular genetics, , Dec-01, Volume: 24, Issue:23, 2015
Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap?Experimental gerontology, , Volume: 68, 2015
Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration.The Journal of biological chemistry, , Aug-07, Volume: 290, Issue:32, 2015
Overexpression of α-synuclein in oligodendrocytes does not increase susceptibility to focal striatal excitotoxicity.BMC neuroscience, , Dec-02, Volume: 16, 2015
Depressive-like phenotype induced by AAV-mediated overexpression of human α-synuclein in midbrain dopaminergic neurons.Experimental neurology, , Volume: 273, 2015
shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model.The Journal of clinical investigation, , Jul-01, Volume: 125, Issue:7, 2015
Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease.Human molecular genetics, , Dec-01, Volume: 24, Issue:23, 2015
High Throughput Sequencing Identifies MicroRNAs Mediating α-Synuclein Toxicity by Targeting Neuroactive-Ligand Receptor Interaction Pathway in Early Stage of Drosophila Parkinson's Disease Model.PloS one, , Volume: 10, Issue:9, 2015
Detection of Disease-associated α-synuclein by Enhanced ELISA in the Brain of Transgenic Mice Overexpressing Human A53T Mutated α-synuclein.Journal of visualized experiments : JoVE, , May-30, Issue:99, 2015
Cyclosporin promotes neurorestoration and cell replacement therapy in pre-clinical models of Parkinson's disease.Acta neuropathologica communications, , Dec-14, Volume: 3, 2015
Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson's disease.Journal of neuroinflammation, , Dec-18, Volume: 12, 2015
Transgenic rodent models to study alpha-synuclein pathogenesis, with a focus on cognitive deficits.Current topics in behavioral neurosciences, , Volume: 22, 2015
Differential calcium alterations in animal models of neurodegenerative disease: Reversal by FK506.Neuroscience, , Dec-03, Volume: 310, 2015
Potential of Cellular and Animal Models Based on a Prion-Like Propagation of α-Synuclein for Assessing Antiparkinson Agents.Molecular neurobiology, , Volume: 52, Issue:1, 2015
Trehalose intake induces chaperone molecules along with autophagy in a mouse model of Lewy body disease.Biochemical and biophysical research communications, , Oct-02, Volume: 465, Issue:4, 2015
Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/α-synuclein aggregation.Autophagy, , Volume: 11, Issue:10, 2015
Evidence for early and progressive ultrasonic vocalization and oromotor deficits in a PINK1 gene knockout rat model of Parkinson's disease.Journal of neuroscience research, , Volume: 93, Issue:11, 2015
Models of multiple system atrophy.Current topics in behavioral neurosciences, , Volume: 22, 2015
LK6/Mnk2a is a new kinase of alpha synuclein phosphorylation mediating neurodegeneration.Scientific reports, , Jul-29, Volume: 5, 2015
Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression.Acta neuropathologica communications, , Jul-25, Volume: 3, 2015
Serotonergic dysfunction in the A53T alpha-synuclein mouse model of Parkinson's disease.Journal of neurochemistry, , Volume: 135, Issue:3, 2015
Failure of Neuroprotection Despite Microglial Suppression by Delayed-Start Myeloperoxidase Inhibition in a Model of Advanced Multiple System Atrophy: Clinical Implications.Neurotoxicity research, , Volume: 28, Issue:3, 2015
Comparison between α-synuclein wild-type and A53T mutation in a progressive Parkinson's disease model.Biochemical and biophysical research communications, , Sep-04, Volume: 464, Issue:4, 2015
Opposing effects of APP/PS1 and TrkB.T1 genotypes on midbrain dopamine neurons and stimulated dopamine release in vivo.Brain research, , Oct-05, Volume: 1622, 2015
Metabolic abnormalities and hypoleptinemia in α-synuclein A53T mutant mice.Neurobiology of aging, , Volume: 35, Issue:5, 2014
Squamosamide derivative FLZ protected dopaminergic neuron by activating Akt signaling pathway in 6-OHDA-induced in vivo and in vitro Parkinson's disease models.Brain research, , Feb-14, Volume: 1547, 2014
Neuroinflammation and α-synuclein accumulation in response to glucocerebrosidase deficiency are accompanied by synaptic dysfunction.Molecular genetics and metabolism, , Volume: 111, Issue:2, 2014
Cystatin C triggers neuronal degeneration in a model of multiple system atrophy.The American journal of pathology, , Volume: 184, Issue:3, 2014
Neuronal inclusions of α-synuclein contribute to the pathogenesis of Krabbe disease.The Journal of pathology, , Volume: 232, Issue:5, 2014
n-butylidenephthalide protects against dopaminergic neuron degeneration and α-synuclein accumulation in Caenorhabditis elegans models of Parkinson's disease.PloS one, , Volume: 9, Issue:1, 2014
Interactions between Tau and α-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease.Human molecular genetics, , Jun-01, Volume: 23, Issue:11, 2014
Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events.Cell, , Jan-16, Volume: 156, Issue:1-2, 2014
The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans.Metallomics : integrated biometal science, , Volume: 6, Issue:3, 2014
Intranasal administration of alpha-synuclein aggregates: a Parkinson's disease model with behavioral and neurochemical correlates.Behavioural brain research, , Apr-15, Volume: 263, 2014
Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:8, 2014
Presynaptic alpha-synuclein aggregation in a mouse model of Parkinson's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-05, Volume: 34, Issue:6, 2014
Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD.Acta neuropathologica, , Volume: 127, Issue:4, 2014
Next-generation active immunization approach for synucleinopathies: implications for Parkinson's disease clinical trials.Acta neuropathologica, , Volume: 127, Issue:6, 2014
Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodies.Molecular neurodegeneration, , May-19, Volume: 9, 2014
Autophagy-lysosome pathway associated neuropathology and axonal degeneration in the brains of alpha-galactosidase A-deficient mice.Acta neuropathologica communications, , Feb-14, Volume: 2, 2014
The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models.Cell metabolism, , Jul-01, Volume: 20, Issue:1, 2014
Olfactory deficits in an alpha-synuclein fly model of Parkinson's disease.PloS one, , Volume: 9, Issue:5, 2014
Zonisamide attenuates α-synuclein neurotoxicity by an aggregation-independent mechanism in a rat model of familial Parkinson's disease.PloS one, , Volume: 9, Issue:2, 2014
Reversibility of neuropathology in Tay-Sachs-related diseases.Human molecular genetics, , Feb-01, Volume: 23, Issue:3, 2014
Towards translational therapies for multiple system atrophy.Progress in neurobiology, , Volume: 118, 2014
Multiple pathogenic proteins implicated in neuronopathic Gaucher disease mice.Human molecular genetics, , Aug-01, Volume: 23, Issue:15, 2014
5-S-cysteinyldopamine neurotoxicity: Influence on the expression of α-synuclein and ERp57 in cellular and animal models of Parkinson's disease.Journal of neuroscience research, , Volume: 92, Issue:3, 2014
Multiple system atrophy of the cerebellar type: clinical state of the art.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:3, 2014
Sleep dysfunction and EEG alterations in mice overexpressing alpha-synuclein.Journal of Parkinson's disease, , Volume: 4, Issue:3, 2014
Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice.Human molecular genetics, , Aug-01, Volume: 23, Issue:15, 2014
Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA.Acta neuropathologica communications, , Mar-13, Volume: 2, 2014
Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicity.Disease models & mechanisms, , Volume: 7, Issue:5, 2014
Neuroprotective effects of mesenchymal stem cells through autophagy modulation in a parkinsonian model.Neurobiology of aging, , Volume: 35, Issue:8, 2014
Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo.Brain : a journal of neurology, , Volume: 137, Issue:Pt 5, 2014
Alpha-synuclein interferes with cAMP/PKA-dependent upregulation of dopamine β-hydroxylase and is associated with abnormal adaptive responses to immobilization stress.Experimental neurology, , Volume: 252, 2014
Effect of epicatechin gallate dietary supplementation on transgenic Drosophila model of Parkinson's disease.Journal of dietary supplements, , Volume: 11, Issue:2, 2014
Vaccination strategies for Parkinson disease: induction of a swift attack or raising tolerance?Human vaccines & immunotherapeutics, , Volume: 10, Issue:4, 2014
Histone deacetylase 6 regulates cytotoxic α-synuclein accumulation through induction of the heat shock response.Neurobiology of aging, , Volume: 35, Issue:10, 2014
Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation.The Journal of clinical investigation, , Volume: 124, Issue:7, 2014
α-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy.Neurobiology of aging, , Volume: 35, Issue:10, 2014
[Alpha-synuclein in Parkinson's disease].Przeglad lekarski, , Volume: 71, Issue:1, 2014
The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse.Neurobiology of disease, , Volume: 68, 2014
PAR2-mediated epigenetic upregulation of α-synuclein contributes to the pathogenesis of Parkinson׳s disease.Brain research, , May-27, Volume: 1565, 2014
Neurogranin binds α-synuclein in the human superior temporal cortex and interaction is decreased in Parkinson's disease.Brain research, , Dec-03, Volume: 1591, 2014
Spermidine protects against α-synuclein neurotoxicity.Cell cycle (Georgetown, Tex.), , Volume: 13, Issue:24, 2014
Mouse models for studying the formation and propagation of prions.The Journal of biological chemistry, , Jul-18, Volume: 289, Issue:29, 2014
Models of α-synuclein aggregation in Parkinson's disease.Acta neuropathologica communications, , Dec-13, Volume: 2, 2014
Binding of the PET radiotracer [¹⁸F]BF227 does not reflect the presence of alpha-synuclein aggregates in transgenic mice.Current Alzheimer research, , Volume: 11, Issue:10, 2014
Toll-like receptor expression in the blood and brain of patients and a mouse model of Parkinson's disease.The international journal of neuropsychopharmacology, , Dec-07, Volume: 18, Issue:6, 2014
Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation.Brain : a journal of neurology, , Volume: 137, Issue:Pt 12, 2014
Using membrane-targeted green fluorescent protein to monitor neurotoxic protein-dependent degeneration of Drosophila eyes.Journal of neuroscience research, , Volume: 92, Issue:9, 2014
Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.Acta neuropathologica, , Volume: 128, Issue:6, 2014
Vocalization deficits in mice over-expressing alpha-synuclein, a model of pre-manifest Parkinson's disease.Behavioral neuroscience, , Volume: 128, Issue:2, 2014
Complex proteinopathy with accumulations of prion protein, hyperphosphorylated tau, α-synuclein and ubiquitin in experimental bovine spongiform encephalopathy of monkeys.The Journal of general virology, , Volume: 95, Issue:Pt 7, 2014
Genetic variants and animal models in SNCA and Parkinson disease.Ageing research reviews, , Volume: 15, 2014
Phosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson disease.Proceedings of the National Academy of Sciences of the United States of America, , Sep-23, Volume: 111, Issue:38, 2014
Using viral-mediated gene delivery to model Parkinson's disease: do nonhuman primate investigations expand our understanding?Experimental neurology, , Volume: 256, 2014
Cardiac sympathetic denervation in 6-OHDA-treated nonhuman primates.PloS one, , Volume: 9, Issue:8, 2014
A new Drosophila model to study the interaction between genetic and environmental factors in Parkinson's disease.Brain research, , Oct-02, Volume: 1583, 2014
Walking deficits and centrophobism in an α-synuclein fly model of Parkinson's disease.Genes, brain, and behavior, , Volume: 13, Issue:8, 2014
Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse.Neurobiology of disease, , Volume: 62, 2014
Adult hippocampal neurogenesis in Parkinson's disease: impact on neuronal survival and plasticity.Neural plasticity, , Volume: 2014, 2014
VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease.Neurobiology of disease, , Volume: 71, 2014
Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques.Neurobiology of disease, , Volume: 71, 2014
α-Synuclein in Parkinson's disease: pathogenic function and translation into animal models.Neuro-degenerative diseases, , Volume: 14, Issue:1, 2014
Late stages of hematopoiesis and B cell lymphopoiesis are regulated by α-synuclein, a key player in Parkinson's disease.Immunobiology, , Volume: 219, Issue:11, 2014
Mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice.Neurobiology of aging, , Volume: 35, Issue:5, 2014
FOXO3 determines the accumulation of α-synuclein and controls the fate of dopaminergic neurons in the substantia nigra.Human molecular genetics, , Mar-15, Volume: 23, Issue:6, 2014
Panax ginseng is neuroprotective in a novel progressive model of Parkinson's disease.Experimental gerontology, , Volume: 50, 2014
A GCase chaperone improves motor function in a mouse model of synucleinopathy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 11, Issue:4, 2014
Tetranectin knockout mice develop features of Parkinson disease.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , Volume: 34, Issue:2, 2014
β-III Tubulin fragments inhibit α-synuclein accumulation in models of multiple system atrophy.The Journal of biological chemistry, , Aug-29, Volume: 289, Issue:35, 2014
Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jul-09, Volume: 34, Issue:28, 2014
Antidepressants reduce neuroinflammatory responses and astroglial alpha-synuclein accumulation in a transgenic mouse model of multiple system atrophy.Glia, , Volume: 62, Issue:2, 2014
Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneurons.PloS one, , Volume: 9, Issue:7, 2014
Protective role of DNJ-27/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases.Antioxidants & redox signaling, , Jan-10, Volume: 20, Issue:2, 2014
Diet-induced obesity accelerates the onset of terminal phenotypes in α-synuclein transgenic mice.Journal of neurochemistry, , Volume: 131, Issue:6, 2014
Dietary energy intake modifies brainstem autonomic dysfunction caused by mutant α-synuclein.Neurobiology of aging, , Volume: 34, Issue:3, 2013
Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of α-synuclein in Parkinson's disease models.Human molecular genetics, , Aug-15, Volume: 22, Issue:16, 2013
Direct detection of alpha synuclein oligomers in vivo.Acta neuropathologica communications, , May-09, Volume: 1, 2013
Potential neuroprotective effect of ibuprofen, insights from the mice model of Parkinson's disease.Pharmacological reports : PR, , Volume: 65, Issue:5, 2013
Olfaction in three genetic and two MPTP-induced Parkinson's disease mouse models.PloS one, , Volume: 8, Issue:10, 2013
Adult neurogenesis in Parkinson's disease.Cellular and molecular life sciences : CMLS, , Volume: 70, Issue:3, 2013
Animal models of Parkinson's disease: limits and relevance to neuroprotection studies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:1, 2013
Caudo-rostral brain spreading of α-synuclein through vagal connections.EMBO molecular medicine, , Volume: 5, Issue:7, 2013
Mitochondria and quality control defects in a mouse model of Gaucher disease--links to Parkinson's disease.Cell metabolism, , Jun-04, Volume: 17, Issue:6, 2013
Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice.Neurobiology of disease, , Volume: 59, 2013
Lentivirus mediated delivery of neurosin promotes clearance of wild-type α-synuclein and reduces the pathology in an α-synuclein model of LBD.Molecular therapy : the journal of the American Society of Gene Therapy, , Volume: 21, Issue:1, 2013
Neuroprotective effects of protocatechuic aldehyde against neurotoxin-induced cellular and animal models of Parkinson's disease.PloS one, , Volume: 8, Issue:10, 2013
α-Synuclein vaccination prevents the accumulation of parkinson disease-like pathologic inclusions in striatum in association with regulatory T cell recruitment in a rat model.Journal of neuropathology and experimental neurology, , Volume: 72, Issue:7, 2013
A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats.Brain : a journal of neurology, , Volume: 136, Issue:Pt 2, 2013
Bladder dysfunction in a transgenic mouse model of multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:3, 2013
rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration.Molecular neurodegeneration, , Nov-25, Volume: 8, 2013
A single dopamine pathway underlies progressive locomotor deficits in a Drosophila model of Parkinson disease.Cell reports, , Nov-27, Volume: 5, Issue:4, 2013
Prion-like spreading of pathological α-synuclein in brain.Brain : a journal of neurology, , Volume: 136, Issue:Pt 4, 2013
Levodopa gains psychostimulant-like properties after nigral dopaminergic loss.Annals of neurology, , Volume: 74, Issue:1, 2013
Neuroimmunological processes in Parkinson's disease and their relation to α-synuclein: microglia as the referee between neuronal processes and peripheral immunity.ASN neuro, , Apr-30, Volume: 5, Issue:2, 2013
The early molecular processes underlying the neurological manifestations of an animal model of Wilson's disease.Metallomics : integrated biometal science, , Volume: 5, Issue:5, 2013
Chronic intranasal deferoxamine ameliorates motor defects and pathology in the α-synuclein rAAV Parkinson's model.Experimental neurology, , Volume: 247, 2013
Behavioral testing regimens in genetic-based animal models of Parkinson's disease: cogencies and caveats.Neuroscience and biobehavioral reviews, , Volume: 37, Issue:5, 2013
Geraniol attenuates α-synuclein expression and neuromuscular impairment through increase dopamine content in MPTP intoxicated mice by dose dependent manner.Biochemical and biophysical research communications, , Nov-01, Volume: 440, Issue:4, 2013
Rasagiline ameliorates olfactory deficits in an alpha-synuclein mouse model of Parkinson's disease.PloS one, , Volume: 8, Issue:4, 2013
Increased SUMO-1 expression in the unilateral rotenone-lesioned mouse model of Parkinson's disease.Neuroscience letters, , Jun-07, Volume: 544, 2013
Oligodendroglial alpha-synucleinopathy and MSA-like cardiovascular autonomic failure: experimental evidence.Experimental neurology, , Volume: 247, 2013
Parkinson's disease and alpha synuclein: is Parkinson's disease a prion-like disorder?Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:1, 2013
Pale body-like inclusion formation and neurodegeneration following depletion of 26S proteasomes in mouse brain neurones are independent of α-synuclein.PloS one, , Volume: 8, Issue:1, 2013
Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model.Autophagy, , Volume: 9, Issue:4, 2013
Parkinson disease: from pathology to molecular disease mechanisms.Free radical biology & medicine, , Volume: 62, 2013
Neural and immune mechanisms in the pathogenesis of Parkinson's disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 8, Issue:1, 2013
Immune effects of optimized DNA vaccine and protective effects in a MPTP model of Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 34, Issue:9, 2013
An ERcentric view of Parkinson's disease.Trends in molecular medicine, , Volume: 19, Issue:3, 2013
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease.Acta neuropathologica, , Volume: 125, Issue:6, 2013
Nasal inoculation with α-synuclein aggregates evokes rigidity, locomotor deficits and immunity to such misfolded species as well as dopamine.Behavioural brain research, , Apr-15, Volume: 243, 2013
The role of Ser129 phosphorylation of α-synuclein in neurodegeneration of Parkinson's disease: a review of in vivo models.Reviews in the neurosciences, , Volume: 24, Issue:2, 2013
Axonopathy in an α-synuclein transgenic model of Lewy body disease is associated with extensive accumulation of C-terminal-truncated α-synuclein.The American journal of pathology, , Volume: 182, Issue:3, 2013
Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies.Proceedings of the National Academy of Sciences of the United States of America, , Feb-26, Volume: 110, Issue:9, 2013
The behavioural and neuropathological impact of intranigral AAV-α-synuclein is exacerbated by systemic infusion of the Parkinson's disease-associated pesticide, rotenone, in rats.Behavioural brain research, , Apr-15, Volume: 243, 2013
Commentary: Progressive inflammation as a contributing factor to early development of Parkinson's disease.Experimental neurology, , Volume: 241, 2013
LRRK2 interactions with α-synuclein in Parkinson's disease brains and in cell models.Journal of molecular medicine (Berlin, Germany), , Volume: 91, Issue:4, 2013
Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice.BMC neuroscience, , Nov-05, Volume: 14, 2013
Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment.Experimental neurology, , Volume: 240, 2013
Development and screening of contrast agents for in vivo imaging of Parkinson's disease.Molecular imaging and biology, , Volume: 15, Issue:5, 2013
α-Synuclein elevation in human neurodegenerative diseases: experimental, pathogenetic, and therapeutic implications.Molecular neurobiology, , Volume: 47, Issue:2, 2013
SF-6 attenuates 6-hydroxydopamine-induced neurotoxicity: an in vitro and in vivo investigation in experimental models of Parkinson's disease.Journal of ethnopharmacology, , Sep-28, Volume: 143, Issue:2, 2012
α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases.Journal of neurochemistry, , Volume: 120, Issue:3, 2012
α-Synuclein accumulates in huntingtin inclusions but forms independent filaments and its deficiency attenuates early phenotype in a mouse model of Huntington's disease.Human molecular genetics, , Feb-01, Volume: 21, Issue:3, 2012
Schizophrenia-like features in transgenic mice overexpressing human HO-1 in the astrocytic compartment.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Aug-08, Volume: 32, Issue:32, 2012
Inclusion of a portion of the native SNCA 3'UTR reduces toxicity of human S129A SNCA on striatal-projecting dopamine neurons in rat substantia nigra.Developmental neurobiology, , Volume: 72, Issue:6, 2012
α-Synuclein levels modulate Huntington's disease in mice.Human molecular genetics, , Feb-01, Volume: 21, Issue:3, 2012
Soluble α-synuclein is a novel modulator of Alzheimer's disease pathophysiology.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jul-25, Volume: 32, Issue:30, 2012
α-Synuclein induces alterations in adult neurogenesis in Parkinson disease models via p53-mediated repression of Notch1.The Journal of biological chemistry, , Sep-14, Volume: 287, Issue:38, 2012
In vivo alterations in calcium buffering capacity in transgenic mouse model of synucleinopathy.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jul-18, Volume: 32, Issue:29, 2012
Animal models of multiple system atrophy.Neuroscience, , Jun-01, Volume: 211, 2012
Phosphorylation of α-synuclein is crucial in compensating for proteasomal dysfunction.Biochemical and biophysical research communications, , Aug-03, Volume: 424, Issue:3, 2012
Effect of L-ascorbic Acid on the climbing ability and protein levels in the brain of Drosophila model of Parkinson's disease.The International journal of neuroscience, , Volume: 122, Issue:12, 2012
A53T-alpha-synuclein-overexpression in the mouse nigrostriatal pathway leads to early increase of 14-3-3 epsilon and late increase of GFAP.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 119, Issue:3, 2012
Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jul-04, Volume: 32, Issue:27, 2012
Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein.Experimental neurology, , Volume: 237, Issue:2, 2012
Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo.PloS one, , Volume: 7, Issue:6, 2012
Do α-synuclein vector injections provide a better model of Parkinson's disease than the classic 6-hydroxydopamine model?Experimental neurology, , Volume: 237, Issue:1, 2012
Prolonged latency to CNS-O2 toxicity induced by heat acclimation in rats is associated with increased antioxidative defenses and metabolic energy preservation.Journal of applied physiology (Bethesda, Md. : 1985), , Aug-15, Volume: 113, Issue:4, 2012
Alpha-synuclein transgenic mice display age-related slowing of gastrointestinal motility associated with transgene expression in the vagal system.Neurobiology of disease, , Volume: 48, Issue:1, 2012
Α-synuclein neuropathology is controlled by nuclear hormone receptors and enhanced by docosahexaenoic acid in a mouse model for Parkinson's disease.Brain pathology (Zurich, Switzerland), , Volume: 22, Issue:3, 2012
α-Synuclein in the olfactory system of a mouse model of Parkinson's disease: correlation with olfactory projections.Brain structure & function, , Volume: 217, Issue:2, 2012
Cognitive dysfunction and depression in Parkinson's disease: what can be learned from rodent models?The European journal of neuroscience, , Volume: 35, Issue:12, 2012
Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain.The Journal of neuroscience : the official journal of the Society for Neuroscience, , May-30, Volume: 32, Issue:22, 2012
Differential inhibition of α-synuclein oligomeric and fibrillar assembly in parkinson's disease model by cinnamon extract.Biochimica et biophysica acta, , Volume: 1820, Issue:10, 2012
Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson's disease models.Critical reviews in toxicology, , Volume: 42, Issue:7, 2012
Mechanisms underlying the impairment of hippocampal long-term potentiation and memory in experimental Parkinson's disease.Brain : a journal of neurology, , Volume: 135, Issue:Pt 6, 2012
α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease.Human molecular genetics, , Jul-15, Volume: 21, Issue:14, 2012
Mitochondrial dysfunction in genetic animal models of Parkinson's disease.Antioxidants & redox signaling, , May-01, Volume: 16, Issue:9, 2012
New agents promote neuroprotection in Parkinson's disease models.CNS & neurological disorders drug targets, , Jun-01, Volume: 11, Issue:4, 2012
The role of the GABA(B) receptor and calcium channels in a Drosophila model of Parkinson's Disease.Neuroscience letters, , May-16, Volume: 516, Issue:2, 2012
α-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion.Neuroscience research, , Volume: 73, Issue:2, 2012
The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease.The Journal of experimental medicine, , Apr-09, Volume: 209, Issue:4, 2012
Regulation of α-synuclein expression in Down syndrome.Journal of neuroscience research, , Volume: 90, Issue:8, 2012
Glucose regulated protein 78 diminishes α-synuclein neurotoxicity in a rat model of Parkinson disease.Molecular therapy : the journal of the American Society of Gene Therapy, , Volume: 20, Issue:7, 2012
The dietary supplementation of nordihydroguaiaretic acid (NDGA) delayed the loss of climbing ability in Drosophila model of Parkinson's disease.Journal of dietary supplements, , Volume: 9, Issue:1, 2012
Mitochondrial permeability transition pore component cyclophilin D distinguishes nigrostriatal dopaminergic death paradigms in the MPTP mouse model of Parkinson's disease.Antioxidants & redox signaling, , May-01, Volume: 16, Issue:9, 2012
Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-07, Volume: 32, Issue:10, 2012
Comparison of the behavioural and histological characteristics of the 6-OHDA and α-synuclein rat models of Parkinson's disease.Experimental neurology, , Volume: 235, Issue:1, 2012
Adenosine A2A receptor gene disruption protects in an α-synuclein model of Parkinson's disease.Annals of neurology, , Volume: 71, Issue:2, 2012
α-Synuclein levels affect autophagosome numbers in vivo and modulate Huntington disease pathology.Autophagy, , Volume: 8, Issue:3, 2012
Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context.Human molecular genetics, , Jun-01, Volume: 21, Issue:11, 2012
Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.Human molecular genetics, , Jun-01, Volume: 21, Issue:11, 2012
Cognitive deficits in a mouse model of pre-manifest Parkinson's disease.The European journal of neuroscience, , Volume: 35, Issue:6, 2012
α-Synuclein in Parkinson's disease.Cold Spring Harbor perspectives in medicine, , Volume: 2, Issue:2, 2012
Synaptic dysfunction in Parkinson's disease.Advances in experimental medicine and biology, , Volume: 970, 2012
A progressive mouse model of Parkinson's disease: the Thy1-aSyn ("Line 61") mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 9, Issue:2, 2012
Generation and characterization of pilocarpine-sensitive C57BL/6 mice as a model of temporal lobe epilepsy.Behavioural brain research, , Apr-21, Volume: 230, Issue:1, 2012
Emerging neurotoxic mechanisms in environmental factors-induced neurodegeneration.Neurotoxicology, , Volume: 33, Issue:4, 2012
Mutant GBA1 expression and synucleinopathy risk: first insights from cellular and mouse models.Neuro-degenerative diseases, , Volume: 10, Issue:1-4, 2012
Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-08, Volume: 32, Issue:6, 2012
Neuronal to oligodendroglial α-synuclein redistribution in a double transgenic model of multiple system atrophy.Neuroreport, , Mar-07, Volume: 23, Issue:4, 2012
Candidate hippocampal biomarkers of susceptibility and resilience to stress in a rat model of depression.Molecular & cellular proteomics : MCP, , Volume: 11, Issue:7, 2012
Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-01, Volume: 32, Issue:5, 2012
Toxic equine parkinsonism: an immunohistochemical study of 10 horses with nigropallidal encephalomalacia.Veterinary pathology, , Volume: 49, Issue:2, 2012
Animal models of Parkinson's disease.The FEBS journal, , Volume: 279, Issue:7, 2012
Animal models of the non-motor features of Parkinson's disease.Neurobiology of disease, , Volume: 46, Issue:3, 2012
Phosphorylation of α-synuclein protein at Ser-129 reduces neuronal dysfunction by lowering its membrane binding property in Caenorhabditis elegans.The Journal of biological chemistry, , Mar-02, Volume: 287, Issue:10, 2012
Use of viral vectors to create animal models for Parkinson's disease.Neurobiology of disease, , Volume: 48, Issue:2, 2012
Binding of neuronal α-synuclein to β-III tubulin and accumulation in a model of multiple system atrophy.Biochemical and biophysical research communications, , Jan-27, Volume: 417, Issue:4, 2012
SIRT1 protects against α-synuclein aggregation by activating molecular chaperones.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jan-04, Volume: 32, Issue:1, 2012
Fluoxetine rescues impaired hippocampal neurogenesis in a transgenic A53T synuclein mouse model.The European journal of neuroscience, , Volume: 35, Issue:1, 2012
Meta-analysis of genetic and environmental Parkinson's disease models reveals a common role of mitochondrial protection pathways.Neurobiology of disease, , Volume: 45, Issue:3, 2012
Development and characterisation of a novel rat model of Parkinson's disease induced by sequential intranigral administration of AAV-α-synuclein and the pesticide, rotenone.Neuroscience, , Feb-17, Volume: 203, 2012
Amyloid generation and dysfunctional immunoproteasome activation with disease progression in animal model of familial Alzheimer's disease.Brain pathology (Zurich, Switzerland), , Volume: 22, Issue:5, 2012
Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons.Neurobiology of disease, , Volume: 45, Issue:3, 2012
Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons.Acta neuropathologica, , Volume: 123, Issue:5, 2012
Myeloperoxidase inhibition ameliorates multiple system atrophy-like degeneration in a transgenic mouse model.Neurotoxicity research, , Volume: 21, Issue:4, 2012
Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression.Molecular and cellular neurosciences, , Volume: 49, Issue:2, 2012
Astrocyte-specific overexpression of Nrf2 delays motor pathology and synuclein aggregation throughout the CNS in the alpha-synuclein mutant (A53T) mouse model.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Dec-05, Volume: 32, Issue:49, 2012
Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate.Scientific reports, , Volume: 2, 2012
Evaluation of TorsinA as a target for Parkinson disease therapy in mouse models.PloS one, , Volume: 7, Issue:11, 2012
Development and characterization of a new Parkinson's disease model resulting from impaired autophagy.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-14, Volume: 32, Issue:46, 2012
Physical training exerts neuroprotective effects in the regulation of neurochemical factors in an animal model of Parkinson's disease.Neuroscience, , Dec-27, Volume: 227, 2012
A spirulina-enhanced diet provides neuroprotection in an α-synuclein model of Parkinson's disease.PloS one, , Volume: 7, Issue:9, 2012
Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease.Molecular neurodegeneration, , Sep-28, Volume: 7, 2012
Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Sep-26, Volume: 32, Issue:39, 2012
Prenatal exposure to methanol as a dopamine system sensitization model in C57BL/6J mice.Life sciences, , Nov-02, Volume: 91, Issue:19-20, 2012
Caenorhabditis elegans as an experimental tool for the study of complex neurological diseases: Parkinson's disease, Alzheimer's disease and autism spectrum disorder.Invertebrate neuroscience : IN, , Volume: 11, Issue:2, 2011
α-synuclein aggregation reduces nigral myocyte enhancer factor-2D in idiopathic and experimental Parkinson's disease.Neurobiology of disease, , Volume: 41, Issue:1, 2011
Identification of bilateral changes in TID1 expression in the 6-OHDA rat model of Parkinson's disease.PloS one, , Volume: 6, Issue:10, 2011
Rab1A over-expression prevents Golgi apparatus fragmentation and partially corrects motor deficits in an alpha-synuclein based rat model of Parkinson's disease.Journal of Parkinson's disease, , Volume: 1, Issue:4, 2011
Tauopathic changes in the striatum of A53T α-synuclein mutant mouse model of Parkinson's disease.PloS one, , Mar-21, Volume: 6, Issue:3, 2011
Mouse models of cognitive deficits due to alpha-synuclein pathology.Journal of Parkinson's disease, , Volume: 1, Issue:3, 2011
Apoptosis in Parkinson's disease: is p53 the missing link between genetic and sporadic Parkinsonism?Cellular signalling, , Volume: 23, Issue:6, 2011
[Alpha-synuclein].Nihon rinsho. Japanese journal of clinical medicine, , Volume: 69 Suppl 8, 2011
Cardiovascular autonomic dysfunction in animal models of Parkinson's disease.Journal of Parkinson's disease, , Volume: 1, Issue:4, 2011
Multiple system atrophy: a clinical and neuropathological perspective.Trends in neurosciences, , Volume: 34, Issue:11, 2011
Accumulation and distribution of α-synuclein and ubiquitin in the CNS of Gaucher disease mouse models.Molecular genetics and metabolism, , Volume: 102, Issue:4, 2011
Anti-Parkinsonian effects of Bacopa monnieri: insights from transgenic and pharmacological Caenorhabditis elegans models of Parkinson's disease.Biochemical and biophysical research communications, , Oct-07, Volume: 413, Issue:4, 2011
Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease.BMC neuroscience, , Aug-03, Volume: 12, 2011
Modeling dopamine neuron degeneration in Caenorhabditis elegans.Methods in molecular biology (Clifton, N.J.), , Volume: 793, 2011
Lipid classes and fatty acid patterns are altered in the brain of γ-synuclein null mutant mice.Lipids, , Volume: 46, Issue:2, 2011
Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α-synuclein.Journal of neuroscience research, , Volume: 89, Issue:7, 2011
Circadian dysfunction in a mouse model of Parkinson's disease.Experimental neurology, , Volume: 232, Issue:1, 2011
Mutant A53T alpha-synuclein induces neuronal death by increasing mitochondrial autophagy.The Journal of biological chemistry, , Mar-25, Volume: 286, Issue:12, 2011
Mutant α-synuclein and aging reduce neurogenesis in the acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.Aging cell, , Volume: 10, Issue:2, 2011
Progressive neurodegeneration or endogenous compensation in an animal model of Parkinson's disease produced by decreasing doses of alpha-synuclein.PloS one, , Mar-07, Volume: 6, Issue:3, 2011
α-Synuclein deficiency and efferent nerve degeneration in the mouse cochlea: a possible cause of early-onset presbycusis.Neuroscience research, , Volume: 71, Issue:3, 2011
Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies.Cell, , Jul-08, Volume: 146, Issue:1, 2011
Lithium protects against oxidative stress-mediated cell death in α-synuclein-overexpressing in vitro and in vivo models of Parkinson's disease.Journal of neuroscience research, , Volume: 89, Issue:10, 2011
Melittin restores proteasome function in an animal model of ALS.Journal of neuroinflammation, , Jun-20, Volume: 8, 2011
Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applications.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:8, 2011
Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease.Disease models & mechanisms, , Volume: 4, Issue:5, 2011
Redox activity of α-synuclein-Cu is silenced by Zn₇-metallothionein-3.Free radical biology & medicine, , Jun-01, Volume: 50, Issue:11, 2011
Mesenchymal stem cells in a transgenic mouse model of multiple system atrophy: immunomodulation and neuroprotection.PloS one, , Volume: 6, Issue:5, 2011
Direct MRI-guided stereotaxic viral mediated gene transfer of alpha-synuclein in the Göttingen minipig CNS.Acta neurobiologiae experimentalis, , Volume: 71, Issue:4, 2011
Tau reduction does not prevent motor deficits in two mouse models of Parkinson's disease.PloS one, , Volume: 6, Issue:12, 2011
The n-terminal 5-MER peptide analogue P165 of amyloid precursor protein exerts protective effects on SH-SY5Y cells and rat hippocampus neuronal synapses.Neuroscience, , Jan-26, Volume: 173, 2011
α-Synuclein expression selectively affects tumorigenesis in mice modeling Parkinson's disease.PloS one, , Volume: 6, Issue:5, 2011
Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing.Annals of neurology, , Volume: 69, Issue:6, 2011
Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-16, Volume: 31, Issue:46, 2011
α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jul-06, Volume: 31, Issue:27, 2011
Induction of the unfolded protein response by α-synuclein in experimental models of Parkinson's disease.Journal of neurochemistry, , Volume: 116, Issue:4, 2011
Decreased reuptake of dopamine in the dorsal striatum in the absence of α-synuclein.Brain research, , Mar-25, Volume: 1382, 2011
Synphilin suppresses α-synuclein neurotoxicity in a Parkinson's disease Drosophila model.Genesis (New York, N.Y. : 2000), , Volume: 49, Issue:5, 2011
Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease.Environmental health perspectives, , Volume: 119, Issue:6, 2011
An α-synuclein AAV gene silencing vector ameliorates a behavioral deficit in a rat model of Parkinson's disease, but displays toxicity in dopamine neurons.Brain research, , Jun-13, Volume: 1395, 2011
Parkin-mediated protection of dopaminergic neurons in a chronic MPTP-minipump mouse model of Parkinson disease.Journal of neuropathology and experimental neurology, , Volume: 70, Issue:8, 2011
Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse model.The Journal of neuroscience : the official journal of the Society for Neuroscience, , May-11, Volume: 31, Issue:19, 2011
Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease.PloS one, , Apr-29, Volume: 6, Issue:4, 2011
Glutathione depletion and overproduction both initiate degeneration of nigral dopaminergic neurons.Acta neuropathologica, , Volume: 121, Issue:4, 2011
Cold water stress attenuates dopaminergic neurotoxicity induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.Acta biochimica et biophysica Sinica, , Volume: 43, Issue:6, 2011
Synaptic dysfunction in genetic models of Parkinson's disease: a role for autophagy?Neurobiology of disease, , Volume: 43, Issue:1, 2011
Converging environmental and genetic pathways in the pathogenesis of Parkinson's disease.Journal of the neurological sciences, , Jul-15, Volume: 306, Issue:1-2, 2011
Olfactory neuron-specific expression of A30P α-synuclein exacerbates dopamine deficiency and hyperactivity in a novel conditional model of early Parkinson's disease stages.Neurobiology of disease, , Volume: 44, Issue:2, 2011
Dopamine-depletion and increased α-synuclein load induce degeneration of cortical cholinergic fibers in mice.Journal of the neurological sciences, , Nov-15, Volume: 310, Issue:1-2, 2011
Erythropoietin is neuroprotective in a transgenic mouse model of multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Feb-15, Volume: 26, Issue:3, 2011
Age and α-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling.Neurobiology of disease, , Volume: 44, Issue:2, 2011
A BACwards glance at neurodegeneration: molecular insights into disease from LRRK2, SNCA and MAPT BAC-transgenic mice.Biochemical Society transactions, , Volume: 39, Issue:4, 2011
A pilot trial of the microtubule-interacting peptide (NAP) in mice overexpressing alpha-synuclein shows improvement in motor function and reduction of alpha-synuclein inclusions.Molecular and cellular neurosciences, , Volume: 46, Issue:3, 2011
Caenorhabditis elegans as a model system for identifying effectors of α-synuclein misfolding and dopaminergic cell death associated with Parkinson's disease.Methods (San Diego, Calif.), , Volume: 53, Issue:3, 2011
Spinal cord and parkinsonism: neuromorphological evidences in humans and experimental studies.Journal of chemical neuroanatomy, , Volume: 42, Issue:4, 2011
Antibody therapy in neurodegenerative disease.Reviews in the neurosciences, , Volume: 21, Issue:4, 2010
Targeted overexpression of human alpha-synuclein in oligodendroglia induces lesions linked to MSA-like progressive autonomic failure.Experimental neurology, , Volume: 224, Issue:2, 2010
Alpha-synuclein deficiency in the C57BL/6JOlaHsd strain does not modify disease progression in the ME7-model of prion disease.Neuroscience, , Feb-03, Volume: 165, Issue:3, 2010
Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline.The Journal of neuroscience : the official journal of the Society for Neuroscience, , May-26, Volume: 30, Issue:21, 2010
Mitochondrial pathobiology in Parkinson's disease and amyotrophic lateral sclerosis.Journal of Alzheimer's disease : JAD, , Volume: 20 Suppl 2, 2010
Upregulation of alpha-synuclein expression in the rat cerebellum in experimental hepatic encephalopathy.Neuropathology and applied neurobiology, , Volume: 36, Issue:5, 2010
SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease.Brain : a journal of neurology, , Volume: 133, Issue:Pt 7, 2010
alpha-Synuclein- and MPTP-generated rodent models of Parkinson's disease and the study of extracellular striatal dopamine dynamics: a microdialysis approach.CNS & neurological disorders drug targets, , Volume: 9, Issue:4, 2010
alpha-Synuclein abnormalities in mouse models of peroxisome biogenesis disorders.Journal of neuroscience research, , Volume: 88, Issue:4, 2010
Forebrain overexpression of alpha-synuclein leads to early postnatal hippocampal neuron loss and synaptic disruption.Experimental neurology, , Volume: 221, Issue:1, 2010
G protein-coupled receptor kinase 5, overexpressed in the alpha-synuclein up-regulation model of Parkinson's disease, regulates bcl-2 expression.Brain research, , Jan-11, Volume: 1307, 2010
Non-invasive evaluation of nigrostriatal neuropathology in a proteasome inhibitor rodent model of Parkinson's disease.BMC neuroscience, , Jan-05, Volume: 11, 2010
The MPTP-lesioned non-human primate models of Parkinson's disease. Past, present, and future.Progress in brain research, , Volume: 184, 2010
Inhibiting α-synuclein oligomerization by stable cell-penetrating β-synuclein fragments recovers phenotype of Parkinson's disease model flies.PloS one, , Nov-10, Volume: 5, Issue:11, 2010
Mice expressing the A53T mutant form of human alpha-synuclein exhibit hyperactivity and reduced anxiety-like behavior.Journal of neuroscience research, , Volume: 88, Issue:8, 2010
Viral vector-mediated overexpression of α-synuclein as a progressive model of Parkinson's disease.Progress in brain research, , Volume: 184, 2010
ASIP Outstanding Investigator Award Lecture. New approaches to the pathology and genetics of neurodegeneration.The American journal of pathology, , Volume: 176, Issue:5, 2010
N(ɛ)-(carboxymethyl)lysine linkage to α-synuclein and involvement of advanced glycation end products in α-synuclein deposits in an MPTP-intoxicated mouse model.Biochimie, , Volume: 92, Issue:10, 2010
Recurrent systemic infections with Streptococcus pneumoniae do not aggravate the course of experimental neurodegenerative diseases.Journal of neuroscience research, , Volume: 88, Issue:5, 2010
Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease.Cell death & disease, , Volume: 1, 2010
Oral administration of rotenone using a gavage and image analysis of alpha-synuclein inclusions in the enteric nervous system.Journal of visualized experiments : JoVE, , Oct-26, Issue:44, 2010
The HSP70 molecular chaperone is not beneficial in a mouse model of alpha-synucleinopathy.PloS one, , Apr-02, Volume: 5, Issue:4, 2010
Drosophila histone deacetylase 6 protects dopaminergic neurons against {alpha}-synuclein toxicity by promoting inclusion formation.Molecular biology of the cell, , Jul-01, Volume: 21, Issue:13, 2010
DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity.Human molecular genetics, , Apr-15, Volume: 19, Issue:8, 2010
Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease.PloS one, , Jan-20, Volume: 5, Issue:1, 2010
Oxidants induce alternative splicing of alpha-synuclein: Implications for Parkinson's disease.Free radical biology & medicine, , Feb-01, Volume: 48, Issue:3, 2010
Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes.Human molecular genetics, , May-01, Volume: 19, Issue:9, 2010
Over-expression of alpha-synuclein in the nervous system enhances axonal degeneration after peripheral nerve lesion in a transgenic mouse strain.Journal of neurochemistry, , Volume: 114, Issue:4, 2010
Genetic mouse models of Parkinson's disease The state of the art.Progress in brain research, , Volume: 184, 2010
Progressive loss of dopaminergic neurons induced by unilateral rotenone infusion into the medial forebrain bundle.Brain research, , Nov-11, Volume: 1360, 2010
Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-17, Volume: 30, Issue:7, 2010
MPTP-induced parkinsonism extends to a subclass of TH-positive neurons in the gut.Brain research, , Oct-08, Volume: 1355, 2010
Bis(thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease.Journal of Alzheimer's disease : JAD, , Volume: 20, Issue:1, 2010
Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy.PloS one, , Feb-19, Volume: 5, Issue:2, 2010
Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jul-07, Volume: 30, Issue:27, 2010
Valproic acid is neuroprotective in the rotenone rat model of Parkinson's disease: involvement of alpha-synuclein.Neurotoxicity research, , Volume: 17, Issue:2, 2010
Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies.Progress in brain research, , Volume: 183, 2010
Mitochondrial α-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo.Neuroscience letters, , Dec-17, Volume: 486, Issue:3, 2010
Lysosomal degradation of alpha-synuclein in vivo.The Journal of biological chemistry, , Apr-30, Volume: 285, Issue:18, 2010
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-03, Volume: 30, Issue:9, 2010
Lovastatin ameliorates alpha-synuclein accumulation and oxidation in transgenic mouse models of alpha-synucleinopathies.Experimental neurology, , Volume: 221, Issue:2, 2010
Selective noradrenergic vulnerability in α-synuclein transgenic mice.Neurobiology of aging, , Volume: 31, Issue:12, 2010
Neurodegeneration in a transgenic mouse model of multiple system atrophy is associated with altered expression of oligodendroglial-derived neurotrophic factors.The Journal of neuroscience : the official journal of the Society for Neuroscience, , May-05, Volume: 30, Issue:18, 2010
Staging of alpha-synuclein in the olfactory bulb in a model of Parkinson's disease: cell types involved.Movement disorders : official journal of the Movement Disorder Society, , Aug-15, Volume: 25, Issue:11, 2010
α-Synuclein transgenic mice reveal compensatory increases in Parkinson's disease-associated proteins DJ-1 and parkin and have enhanced α-synuclein and PINK1 levels after rotenone treatment.Journal of molecular neuroscience : MN, , Volume: 42, Issue:2, 2010
Alpha-synuclein deficient mice are resistant to toxin-induced multiple system atrophy.Neuroreport, , Apr-21, Volume: 21, Issue:6, 2010
Trichloroethylene induces dopaminergic neurodegeneration in Fisher 344 rats.Journal of neurochemistry, , Volume: 112, Issue:3, 2010
No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Jul-30, Volume: 24, Issue:10, 2009
Neurotoxic conversion of beta-synuclein: a novel approach to generate a transgenic mouse model of synucleinopathies?Journal of neurology, , Volume: 256 Suppl 3, 2009
A highly reproducible rotenone model of Parkinson's disease.Neurobiology of disease, , Volume: 34, Issue:2, 2009
Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models.The EMBO journal, , Oct-21, Volume: 28, Issue:20, 2009
Mitochondrial inhibitor 3-nitroproprionic acid enhances oxidative modification of alpha-synuclein in a transgenic mouse model of multiple system atrophy.Journal of neuroscience research, , Volume: 87, Issue:12, 2009
Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Oct-28, Volume: 29, Issue:43, 2009
Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism.Neurotoxicology, , Volume: 30, Issue:6, 2009
The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson's disease.Journal of neurochemistry, , Volume: 110, Issue:1, 2009
alpha-synuclein and LRRK2: partners in crime.Neuron, , Dec-24, Volume: 64, Issue:6, 2009
Alpha-synuclein induces migration of BV-2 microglial cells by up-regulation of CD44 and MT1-MMP.Journal of neurochemistry, , Volume: 109, Issue:5, 2009
Differences between subacute and chronic MPTP mice models: investigation of dopaminergic neuronal degeneration and alpha-synuclein inclusions.Journal of neurochemistry, , Volume: 109, Issue:5, 2009
Striatal transplantation for multiple system atrophy--are grafts affected by alpha-synucleinopathy?Experimental neurology, , Volume: 219, Issue:1, 2009
Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases.Journal of neurochemistry, , Volume: 109, Issue:5, 2009
Desipramine modulation of alpha-, gamma-synuclein, and the norepinephrine transporter in an animal model of depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, , Volume: 34, Issue:4, 2009
[In-vivo imaging for pursuing molecular cascades in the pathogenesis of neurodegenerative diseases].Rinsho shinkeigaku = Clinical neurology, , Volume: 49, Issue:11, 2009
Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration.PloS one, , Jun-03, Volume: 4, Issue:6, 2009
Modelling Parkinson's disease in Drosophila.Neuromolecular medicine, , Volume: 11, Issue:4, 2009
Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation.The Journal of clinical investigation, , Volume: 119, Issue:11, 2009
Expression of alpha-synuclein is increased in the hippocampus of rats with high levels of innate anxiety.Molecular psychiatry, , Volume: 14, Issue:9, 2009
Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology.Neurobiology of disease, , Volume: 36, Issue:1, 2009
Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease.Journal of neuropathology and experimental neurology, , Volume: 68, Issue:5, 2009
Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease.Human molecular genetics, , Mar-01, Volume: 18, Issue:5, 2009
CD4+ T cells mediate cytotoxicity in neurodegenerative diseases.The Journal of clinical investigation, , Volume: 119, Issue:1, 2009
Effects of UCH-L1 on alpha-synuclein over-expression mouse model of Parkinson's disease.Journal of neurochemistry, , Volume: 108, Issue:4, 2009
The ALS/PDC syndrome of Guam and the cycad hypothesis.Neurology, , Feb-03, Volume: 72, Issue:5, 2009
Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson's disease model.Rejuvenation research, , Volume: 12, Issue:5, 2009
Subchronic infusion of the product of inflammation prostaglandin J2 models sporadic Parkinson's disease in mice.Journal of neuroinflammation, , Jul-25, Volume: 6, 2009
Stereotaxical infusion of rotenone: a reliable rodent model for Parkinson's disease.PloS one, , Nov-18, Volume: 4, Issue:11, 2009
Nigral degeneration with inclusion body formation and behavioral changes in rats after proteasomal inhibition.Stereotactic and functional neurosurgery, , Volume: 87, Issue:2, 2009
Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-18, Volume: 29, Issue:7, 2009
Nuclear and neuritic distribution of serine-129 phosphorylated alpha-synuclein in transgenic mice.Neuroscience, , Jun-02, Volume: 160, Issue:4, 2009
Microtubule depolymerization suppresses alpha-synuclein accumulation in a mouse model of multiple system atrophy.The American journal of pathology, , Volume: 174, Issue:4, 2009
Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-18, Volume: 29, Issue:11, 2009
Alpha-Synuclein contributes to GSK-3beta-catalyzed Tau phosphorylation in Parkinson's disease models.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 23, Issue:9, 2009
Animal models of neurodegenerative diseases.Methods in molecular biology (Clifton, N.J.), , Volume: 549, 2009
alpha-Synucleinopathy models and human neuropathology: similarities and differences.Acta neuropathologica, , Volume: 115, Issue:1, 2008
In vivo alpha-synuclein overexpression in rodents: a useful model of Parkinson's disease?Experimental neurology, , Volume: 209, Issue:1, 2008
Rifampicin reduces alpha-synuclein in a transgenic mouse model of multiple system atrophy.Neuroreport, , Aug-27, Volume: 19, Issue:13, 2008
Characterization of the striatal 6-OHDA model of Parkinson's disease in wild type and alpha-synuclein-deleted mice.Experimental neurology, , Volume: 210, Issue:1, 2008
Noninvasive measurement of protein aggregation by mutant huntingtin fragments or alpha-synuclein in the lens.The Journal of biological chemistry, , Mar-07, Volume: 283, Issue:10, 2008
Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species.Biochemistry, , Sep-09, Volume: 47, Issue:36, 2008
The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease.Proceedings of the National Academy of Sciences of the United States of America, , Jan-15, Volume: 105, Issue:2, 2008
Is alpha-synuclein the culprit of the Parkinsonian neurodegeneration?Experimental neurology, , Volume: 209, Issue:1, 2008
Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jan-09, Volume: 28, Issue:2, 2008
Transcriptional dysregulation in a transgenic model of Parkinson disease.Neurobiology of disease, , Volume: 29, Issue:3, 2008
Rasagiline is neuroprotective in a transgenic model of multiple system atrophy.Experimental neurology, , Volume: 210, Issue:2, 2008
Abnormal colonic motility in mice overexpressing human wild-type alpha-synuclein.Neuroreport, , May-28, Volume: 19, Issue:8, 2008
Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:5, 2008
Transgenic mice overexpressing tyrosine-to-cysteine mutant human alpha-synuclein: a progressive neurodegenerative model of diffuse Lewy body disease.The Journal of biological chemistry, , Apr-11, Volume: 283, Issue:15, 2008
Superoxide dismutase overexpression protects dopaminergic neurons in a Drosophila model of Parkinson's disease.Neurobiology of disease, , Volume: 30, Issue:1, 2008
Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease.The Journal of clinical investigation, , Volume: 118, Issue:9, 2008
Genetic models of Parkinson's disease: mechanisms and therapies.SEB experimental biology series, , Volume: 60, 2008
Generation of a alpha-synuclein-based rat model of Parkinson's disease.Neurobiology of disease, , Volume: 30, Issue:1, 2008
Alpha-synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: lessons from viral transduction of knockout mice.Neuroscience letters, , Apr-11, Volume: 435, Issue:1, 2008
Quantitative proteomics of a presymptomatic A53T alpha-synuclein Drosophila model of Parkinson disease.Molecular & cellular proteomics : MCP, , Volume: 7, Issue:7, 2008
Value of genetic models in understanding the cause and mechanisms of Parkinson's disease.Current neurology and neuroscience reports, , Volume: 8, Issue:4, 2008
High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in a Drosophila model of Parkinson's disease.Journal of neuroscience research, , Volume: 86, Issue:9, 2008
Viral vectors, animal models and new therapies for Parkinson's disease.Parkinsonism & related disorders, , Volume: 14 Suppl 2, 2008
Proteasomal abnormalities in cortical Lewy body disease and the impact of proteasomal inhibition within cortical and cholinergic systems.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 115, Issue:6, 2008
Pathologic modifications of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated squirrel monkeys.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:8, 2008
Targeted overexpression of human alpha-synuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson disease.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:12, 2008
Application of a C. elegans dopamine neuron degeneration assay for the validation of potential Parkinson's disease genes.Journal of visualized experiments : JoVE, , Jul-18, Issue:17, 2008
Modulation of alpha-synuclein expression in transgenic animals for modelling synucleinopathies--is the juice worth the squeeze?Neurotoxicity research, , Volume: 14, Issue:4, 2008
Pink1 suppresses alpha-synuclein-induced phenotypes in a Drosophila model of Parkinson's disease.Genome, , Volume: 51, Issue:12, 2008
Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease.Neuroscience letters, , Jul-11, Volume: 439, Issue:2, 2008
Proteome response to the panneural expression of human wild-type alpha-synuclein: a Drosophila model of Parkinson's disease.Journal of proteome research, , Volume: 7, Issue:9, 2008
Dopamine receptor agonists reverse behavioral abnormalities of alpha-synuclein transgenic mouse, a new model of Parkinson's disease.Journal of neuroscience research, , Feb-15, Volume: 86, Issue:3, 2008
Animal models in neurodegenerative diseases.Journal of neural transmission. Supplementum, , Issue:72, 2007
ATP depletion is the major cause of MPP+ induced dopamine neuronal death and worm lethality in alpha-synuclein transgenic C. elegans.Neuroscience bulletin, , Volume: 23, Issue:6, 2007
[Animal models for familial Parkinson's disease].Rinsho shinkeigaku = Clinical neurology, , Volume: 47, Issue:11, 2007
Is alpha-synuclein pathology a target for treatment of neurodegenerative disorders?Current Alzheimer research, , Volume: 4, Issue:5, 2007
Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression.Neurobiology of aging, , Volume: 28, Issue:2, 2007
Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice.Neurobiology of aging, , Volume: 28, Issue:9, 2007
Protein expression in a Drosophila model of Parkinson's disease.Journal of proteome research, , Volume: 6, Issue:1, 2007
Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD.Experimental neurology, , Volume: 204, Issue:1, 2007
[Animal models of neurodegenerative diseases].Medecine sciences : M/S, , Volume: 23, Issue:2, 2007
Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity.Neuron, , Feb-15, Volume: 53, Issue:4, 2007
Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.Journal of neurochemistry, , Volume: 101, Issue:6, 2007
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.Science (New York, N.Y.), , Jul-27, Volume: 317, Issue:5837, 2007
Medicine. The yin-yang of sirtuins.Science (New York, N.Y.), , Jul-27, Volume: 317, Issue:5837, 2007
The effect of truncated human alpha-synuclein (1-120) on dopaminergic cells in a transgenic mouse model of Parkinson's disease.Cell transplantation, , Volume: 16, Issue:5, 2007
Impairment of the ubiquitin-proteasome system associated with extracellular transthyretin aggregates in familial amyloidotic polyneuropathy.The Journal of pathology, , Volume: 213, Issue:2, 2007
Transgenic animal models of neurodegenerative diseases and their application to treatment development.Advanced drug delivery reviews, , Sep-30, Volume: 59, Issue:11, 2007
Behavioral and histopathological consequences of paraquat intoxication in mice: effects of alpha-synuclein over-expression.Synapse (New York, N.Y.), , Volume: 61, Issue:12, 2007
Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans.The Journal of biological chemistry, , Jan-06, Volume: 281, Issue:1, 2006
Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system.Neurobiology of disease, , Volume: 22, Issue:2, 2006
Down-regulation of alpha-synuclein expression can rescue dopaminergic cells from cell death in the substantia nigra of Parkinson's disease rat model.Biochemical and biophysical research communications, , Mar-24, Volume: 341, Issue:4, 2006
6-Hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation.The Journal of biological chemistry, , Apr-07, Volume: 281, Issue:14, 2006
Drosophila models pioneer a new approach to drug discovery for Parkinson's disease.Drug discovery today, , Volume: 11, Issue:3-4, 2006
Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Apr-05, Volume: 26, Issue:14, 2006
Proteasome dysfunction in aged human alpha-synuclein transgenic mice.Neurobiology of disease, , Volume: 23, Issue:1, 2006
Comparison of alpha-synuclein immunoreactivity and protein levels in ischemic hippocampal CA1 region between adult and aged gerbils and correlation with Cu,Zn-superoxide dismutase.Neuroscience research, , Volume: 55, Issue:4, 2006
Mutant alpha-synuclein-induced degeneration is reduced by parkin in a fly model of Parkinson's disease.Genome, , Volume: 49, Issue:5, 2006
Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models.Science (New York, N.Y.), , Jul-21, Volume: 313, Issue:5785, 2006
Embryonic stem cell-derived neuron models of Parkinson's disease exhibit delayed neuronal death.Journal of neurochemistry, , Volume: 98, Issue:1, 2006
Ventral tegmental area dopamine neurons are resistant to human mutant alpha-synuclein overexpression.Neurobiology of disease, , Volume: 23, Issue:3, 2006
Glial degeneration and reactive gliosis in alpha-synucleinopathies: the emerging concept of primary gliodegeneration.Acta neuropathologica, , Volume: 112, Issue:5, 2006
Dynamic modeling of alpha-synuclein aggregation for the sporadic and genetic forms of Parkinson's disease.Neuroscience, , Oct-27, Volume: 142, Issue:3, 2006
Mechanisms and models of alpha-synuclein-related neurodegeneration.Current neurology and neuroscience reports, , Volume: 6, Issue:5, 2006
Behavioral effects of dopaminergic agonists in transgenic mice overexpressing human wildtype alpha-synuclein.Neuroscience, , Nov-03, Volume: 142, Issue:4, 2006
PEP-1-SOD fusion protein efficiently protects against paraquat-induced dopaminergic neuron damage in a Parkinson disease mouse model.Free radical biology & medicine, , Oct-01, Volume: 41, Issue:7, 2006
A short overview on the role of alpha-synuclein and proteasome in experimental models of Parkinson's disease.Journal of neural transmission. Supplementum, , Issue:70, 2006
Alpha-synuclein overexpression model.Journal of neural transmission. Supplementum, , Issue:70, 2006
Regulation of alpha-synuclein expression in alcohol-preferring and -non preferring rats.Journal of neurochemistry, , Volume: 99, Issue:2, 2006
Alpha-synuclein induces hyperphosphorylation of Tau in the MPTP model of parkinsonism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 20, Issue:13, 2006
Animal models of tauopathies.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 26, Issue:5, 2006
Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-15, Volume: 26, Issue:46, 2006
Rescuing defective vesicular trafficking protects against alpha-synuclein toxicity in cellular and animal models of Parkinson's disease.ACS chemical biology, , Aug-22, Volume: 1, Issue:7, 2006
Mitochondrial associated metabolic proteins are selectively oxidized in A30P alpha-synuclein transgenic mice--a model of familial Parkinson's disease.Neurobiology of disease, , Volume: 18, Issue:3, 2005
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.The Journal of biological chemistry, , Dec-30, Volume: 280, Issue:52, 2005
Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human alpha-synuclein.Neurobiology of disease, , Volume: 20, Issue:2, 2005
Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein.Molecular and cellular biology, , Volume: 25, Issue:22, 2005
Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat.Neurobiology of disease, , Volume: 20, Issue:1, 2005
Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and drug-induced rotational asymmetry in hemi-parkinsonian rats.Journal of neurochemistry, , Volume: 95, Issue:4, 2005
Neurological and neurodegenerative alterations in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-16, Volume: 25, Issue:46, 2005
Alpha-synuclein transgenic mice: relevance to multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
Neuroscientists put gene therapy into reverse.Nature, , Nov-24, Volume: 438, Issue:7067, 2005
[Effects of different doses of levodopa on paraquat-induced neurotoxicity: an experiment with mice].Zhonghua yi xue za zhi, , Sep-07, Volume: 85, Issue:34, 2005
Marmoset monkey models of Parkinson's disease: which model, when and why?Brain research bulletin, , Dec-30, Volume: 68, Issue:3, 2005
Alpha-synuclein expression in the substantia nigra of MPTP-lesioned non-human primates.Neurobiology of disease, , Volume: 20, Issue:3, 2005
Genetic mouse models of parkinsonism: strengths and limitations.NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 2, Issue:3, 2005
Sticking it to Parkinson's disease.Science of aging knowledge environment : SAGE KE, , Jun-22, Volume: 2005, Issue:25, 2005
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Physico-Pathologic Mechanisms Involved in Neurodegeneration: Misfolded Protein-Plasma Membrane Interactions.Neuron, , Jul-05, Volume: 95, Issue:1, 2017
The Medicinal Chemistry of Natural and Semisynthetic Compounds against Parkinson's and Huntington's Diseases.ACS chemical neuroscience, , 11-15, Volume: 8, Issue:11, 2017
Secretory carrier membrane protein 5 is an autophagy inhibitor that promotes the secretion of α-synuclein via exosome.PloS one, , Volume: 12, Issue:7, 2017
Trehalose rescues glial cell dysfunction in striatal cultures from HD R6/1 mice at early postnatal development.Molecular and cellular neurosciences, , Volume: 74, 2016
[A Therapeutic Target for Inhibition of Neurodegeneration: Autophagy].Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova, , Volume: 66, Issue:5, 2016
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Personalized medicine strategies for managing patients with parkinsonism and cognitive deficits.Metabolism: clinical and experimental, , Volume: 62 Suppl 1, 2013
Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells.International journal of molecular sciences, , Nov-15, Volume: 14, Issue:11, 2013
α-Synuclein accumulates in huntingtin inclusions but forms independent filaments and its deficiency attenuates early phenotype in a mouse model of Huntington's disease.Human molecular genetics, , Feb-01, Volume: 21, Issue:3, 2012
α-Synuclein modifies huntingtin aggregation in living cells.FEBS letters, , Jan-02, Volume: 586, Issue:1, 2012
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Positive lysosomal modulation as a unique strategy to treat age-related protein accumulation diseases.Rejuvenation research, , Volume: 15, Issue:2, 2012
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α-Synuclein levels affect autophagosome numbers in vivo and modulate Huntington disease pathology.Autophagy, , Volume: 8, Issue:3, 2012
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ASIP Outstanding Investigator Award Lecture. New approaches to the pathology and genetics of neurodegeneration.The American journal of pathology, , Volume: 176, Issue:5, 2010
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Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases.Journal of neurochemistry, , Volume: 109, Issue:5, 2009
Noninvasive measurement of protein aggregation by mutant huntingtin fragments or alpha-synuclein in the lens.The Journal of biological chemistry, , Mar-07, Volume: 283, Issue:10, 2008
Protein folding diseases and neurodegeneration: lessons learned from yeast.Biochimica et biophysica acta, , Volume: 1783, Issue:7, 2008
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.The Journal of biological chemistry, , Feb-23, Volume: 282, Issue:8, 2007
Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases.Proceedings of the National Academy of Sciences of the United States of America, , Mar-14, Volume: 103, Issue:11, 2006
[The neuroprotective B2 strengthens the aggregation of unfolded protein in Huntington chorea and Parkinson disease].Pharmazie in unserer Zeit, , Volume: 35, Issue:6, 2006
Neuroscientists put gene therapy into reverse.Nature, , Nov-24, Volume: 438, Issue:7067, 2005
Genetic testing in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20, Issue:1, 2005
Modeling CNS neurodegeneration by overexpression of disease-causing proteins using viral vectors.Trends in neurosciences, , Volume: 26, Issue:7, 2003
Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation.Molecular biology of the cell, , Volume: 12, Issue:5, 2001
Genetics of movement disorders: an abbreviated overview.Stereotactic and functional neurosurgery, , Volume: 77, Issue:1-4, 2001
Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins.Mechanisms of ageing and development, , Jul-15, Volume: 122, Issue:9, 2001
Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?Nature cell biology, , Volume: 2, Issue:7, 2000
Alpha-synuclein immunoreactivity of huntingtin polyglutamine aggregates in striatum and cortex of Huntington's disease patients and transgenic mouse models.Neuroscience letters, , Jul-28, Volume: 289, Issue:1, 2000
A review on the cause-effect relationship between oxidative stress and toxic proteins in the pathogenesis of neurodegenerative diseases.Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, , Volume: 118, Issue:1
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Alpha-Synuclein RT-QuIC in Idiopathic Normal Pressure Hydrocephalus.Annals of neurology, , Volume: 92, Issue:6, 2022
In vivo assessment of Lewy body and beta-amyloid copathologies in idiopathic normal pressure hydrocephalus: prevalence and associations with clinical features and surgery outcome.Fluids and barriers of the CNS, , Sep-07, Volume: 19, Issue:1, 2022
A unique glycan-isoform of transferrin in cerebrospinal fluid: A potential diagnostic marker for neurological diseases.Biochimica et biophysica acta. General subjects, , Volume: 1861, Issue:10, 2017
Decreased Expression of hsa-miR-4274 in Cerebrospinal Fluid of Normal Pressure Hydrocephalus Mimics with Parkinsonian Syndromes.Journal of Alzheimer's disease : JAD, , Volume: 56, Issue:1, 2017
Recommendations for cerebrospinal fluid collection for the analysis by ELISA of neurogranin trunc P75, α-synuclein, and total tau in combination with Aβ(1-42)/Aβ(1-40).Alzheimer's research & therapy, , Jun-06, Volume: 9, Issue:1, 2017
α-Synuclein in human cerebrospinal fluid is principally derived from neurons of the central nervous system.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 119, Issue:7, 2012
Long-term hyperglycemia aggravates α-synuclein aggregation and dopaminergic neuronal loss in a Parkinson's disease mouse model.Translational neurodegeneration, , 03-07, Volume: 11, Issue:1, 2022
Type 2 diabetes mellitus augments Parkinson's disease risk or the other way around: Facts, challenges and future possibilities.Ageing research reviews, , Volume: 81, 2022
A newly discovered neurotoxin ADTIQ associated with hyperglycemia and Parkinson's disease.Biochemical and biophysical research communications, , Apr-10, Volume: 459, Issue:3, 2015
MicroRNA expressing profiles in A53T mutant alpha-synuclein transgenic mice and Parkinsonian.Oncotarget, , Jan-03, Volume: 8, Issue:1, 2017
Non-motor parkinsonian pathology in aging A53T α-synuclein mice is associated with progressive synucleinopathy and altered enzymatic function.Journal of neurochemistry, , Volume: 128, Issue:4, 2014
Olfactory neuron-specific expression of A30P α-synuclein exacerbates dopamine deficiency and hyperactivity in a novel conditional model of early Parkinson's disease stages.Neurobiology of disease, , Volume: 44, Issue:2, 2011
Mice expressing the A53T mutant form of human alpha-synuclein exhibit hyperactivity and reduced anxiety-like behavior.Journal of neuroscience research, , Volume: 88, Issue:8, 2010
Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein.The European journal of neuroscience, , Volume: 27, Issue:4, 2008
Locomotor hyperactivity and alterations in dopamine neurotransmission are associated with overexpression of A53T mutant human alpha-synuclein in mice.Neurobiology of disease, , Volume: 21, Issue:2, 2006
Parkinson-like early autonomic dysfunction induced by vagal application of DOPAL in rats.CNS neuroscience & therapeutics, , Volume: 27, Issue:5, 2021
A Longitudinal Skin Biopsy Study of Phosphorylated Alpha-Synuclein in a Patient With Parkinson Disease and Orthostatic Hypotension.Journal of neuropathology and experimental neurology, , 07-01, Volume: 79, Issue:7, 2020
Skin Biopsy May Help to Distinguish Multiple System Atrophy-Parkinsonism from Parkinson's Disease With Orthostatic Hypotension.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:9, 2020
Orthostatic hypotension as a core symptom in a Japanese family harboring SNCA duplication.Parkinsonism & related disorders, , Volume: 81, 2020
Skin Nerve Phosphorylated α-Synuclein Deposits in Parkinson Disease With Orthostatic Hypotension.Journal of neuropathology and experimental neurology, , 10-01, Volume: 77, Issue:10, 2018
Medullary neuronal loss is not associated with α-synuclein burden in multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:12, 2016
'Under pressure': is there a link between orthostatic hypotension and cognitive impairment in α-synucleinopathies?Journal of neurology, neurosurgery, and psychiatry, , Volume: 87, Issue:12, 2016
Concomitant alpha-synuclein pathology in an autopsy case of amyotrophic lateral sclerosis presenting with orthostatic hypotension and cardiac arrests.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 34, Issue:2, 2014
The potential prognostic role of cardiovascular autonomic failure in α-synucleinopathies.European journal of neurology, , Volume: 20, Issue:2, 2013
Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Jun-15, Volume: 23, Issue:8, 2008
Dementia with Lewy bodies in an elderly Greek male due to alpha-synuclein gene mutation.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, , Volume: 13, Issue:9, 2006
How to diagnose dementia with Lewy bodies: state of the art.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
Association between cardiac denervation and parkinsonism caused by alpha-synuclein gene triplication.Brain : a journal of neurology, , Volume: 127, Issue:Pt 4, 2004
[Recent neuropathology of parkinsonian syndromes].Revue neurologique, , Volume: 159, Issue:5 Pt 2, 2003
Sympathetic neurocirculatory failure in Parkinson disease: Evidence for an etiologic role of alpha-synuclein.Annals of internal medicine, , Dec-04, Volume: 135, Issue:11, 2001
Impulse control disorder, lysosomal malfunction and ATP13A2 insufficiency in Parkinsonism.Clinical and experimental pharmacology & physiology, , Volume: 44, Issue:2, 2017
Evidence of a role for SNCA in impulse control in humans.Neurogenetics, , Volume: 15, Issue:1, 2014
Alpha synuclein protein levels are increased in serum from recently abstinent cocaine abusers.Drug and alcohol dependence, , Apr-01, Volume: 94, Issue:1-3, 2008
The Possible Protective Role of α-Synuclein Against Severe Acute Respiratory Syndrome Coronavirus 2 Infections in Patients With Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:8, 2020
Can infections trigger alpha-synucleinopathies?Progress in molecular biology and translational science, , Volume: 168, 2019
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Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease.Molecular neurodegeneration, , 07-04, Volume: 18, Issue:1, 2023
Three-dimensional neuroimmune co-culture system for modeling Parkinson's disease microenvironmentsBiofabrication, , 07-10, Volume: 15, Issue:4, 2023
Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of Parkinson disease.Nature communications, , 06-26, Volume: 14, Issue:1, 2023
Necrosulfonamide exerts neuroprotective effect by inhibiting necroptosis, neuroinflammation, and α-synuclein oligomerization in a subacute MPTP mouse model of Parkinson's disease.Scientific reports, , 05-31, Volume: 13, Issue:1, 2023
Impact of sex on neuroimmune contributions to Parkinson's disease.Brain research bulletin, , Volume: 199, 2023
Synucleinopathies Take Their Toll: Are TLRs a Way to Go?Cells, , 04-24, Volume: 12, Issue:9, 2023
Involvement of Abnormal p-α-syn Accumulation and TLR2-Mediated Inflammation of Schwann Cells in Enteric Autonomic Nerve Dysfunction of Parkinson's Disease: an Animal Model Study.Molecular neurobiology, , Volume: 60, Issue:8, 2023
Revisiting Alpha-Synuclein Pathways to Inflammation.International journal of molecular sciences, , Apr-12, Volume: 24, Issue:8, 2023
Cntnap4 partial deficiency exacerbates α-synuclein pathology through astrocyte-microglia C3-C3aR pathway.Cell death & disease, , 04-22, Volume: 14, Issue:4, 2023
Lewy bodies, iron, inflammation and neuromelanin: pathological aspects underlying Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 130, Issue:5, 2023
The cervical lymph node contributes to peripheral inflammation related to Parkinson's disease.Journal of neuroinflammation, , Apr-10, Volume: 20, Issue:1, 2023
Role of enteric glia and microbiota-gut-brain axis in parkinson disease pathogenesis.Ageing research reviews, , Volume: 84, 2023
Alpha Synuclein: Neurodegeneration and Inflammation.International journal of molecular sciences, , Mar-21, Volume: 24, Issue:6, 2023
Alpha-synuclein in Parkinson's disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction.Cell death & disease, , 03-01, Volume: 14, Issue:3, 2023
Mitochondrial signaling on innate immunity activation in Parkinson disease.Current opinion in neurobiology, , Volume: 78, 2023
Helicobacter hepaticus augmentation triggers Dopaminergic degeneration and motor disorders in mice with Parkinson's disease.Molecular psychiatry, , Volume: 28, Issue:3, 2023
Myrcene Salvages Rotenone-Induced Loss of Dopaminergic Neurons by Inhibiting Oxidative Stress, Inflammation, Apoptosis, and Autophagy.Molecules (Basel, Switzerland), , Jan-10, Volume: 28, Issue:2, 2023
Aggregated alpha-synuclein transcriptionally activates pro-inflammatory canonical and non-canonical NF-κB signaling pathways in peripheral monocytic cells.Molecular immunology, , Volume: 154, 2023
The Mediating Role of Inflammation in the Relationship Between α-Synuclein and Cognitive Functioning.The journals of gerontology. Series A, Biological sciences and medical sciences, , 02-24, Volume: 78, Issue:2, 2023
Coumarin-chalcone hybrid LM-021 and indole derivative NC009-1 targeting inflammation and oxidative stress to protect BE(2)-M17 cells against α-synuclein toxicity.Aging, , 08-11, Volume: 15, Issue:16, 2023
Microglia and astrocyte activation is region-dependent in the α-synuclein mouse model of Parkinson's disease.Glia, , Volume: 71, Issue:3, 2023
Investigation of Inflammation in Lewy Body Dementia: A Systematic Scoping Review.International journal of molecular sciences, , Jul-28, Volume: 24, Issue:15, 2023
The Hyperproliferation Mechanism of Cholesteatoma Based on Proteomics: SNCA Promotes Autophagy-Mediated Cell Proliferation Through the PI3K/AKT/CyclinD1 Signaling Pathway.Molecular & cellular proteomics : MCP, , Volume: 22, Issue:9, 2023
TNF-α promotes α-synuclein propagation through stimulation of senescence-associated lysosomal exocytosis.Experimental & molecular medicine, , Volume: 54, Issue:6, 2022
Effects of miRNAs in exosomes derived from α-synuclein overexpressing SH-SY5Y cells on autophagy and inflammation of microglia.Cellular signalling, , Volume: 89, 2022
The influence of preconditioning with low dose of LPS on paraquat-induced neurotoxicity, microglia activation and expression of α-synuclein and synphilin-1 in the dopaminergic system.Pharmacological reports : PR, , Volume: 74, Issue:1, 2022
Inflammasome Activation in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
Therapeutic Strategies for Immune Transformation in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
Dysregulation of peripheral monocytes and pro-inflammation of alpha-synuclein in Parkinson's disease.Journal of neurology, , Volume: 269, Issue:12, 2022
Inflammation promotes synucleinopathy propagation.Experimental & molecular medicine, , Volume: 54, Issue:12, 2022
LncRNA miR-17-92a-1 cluster host gene (MIR17HG) promotes neuronal damage and microglial activation by targeting the microRNA-153-3p/alpha-synuclein axis in Parkinson's disease.Bioengineered, , Volume: 13, Issue:2, 2022
Ischemic stroke causes Parkinson's disease-like pathology and symptoms in transgenic mice overexpressing alpha-synuclein.Acta neuropathologica communications, , 02-24, Volume: 10, Issue:1, 2022
Mechanisms of NLRP3 activation and pathology during neurodegeneration.The international journal of biochemistry & cell biology, , Volume: 151, 2022
LRRK2 Inhibition Mitigates the Neuroinflammation Caused by TLR2-Specific α-Synuclein and Alleviates Neuroinflammation-Derived Dopaminergic Neuronal Loss.Cells, , 03-02, Volume: 11, Issue:5, 2022
Oligomeric α-Synuclein induces skin degeneration in reconstructed human epidermis.Neurobiology of aging, , Volume: 113, 2022
Role of NLRP3 Inflammasome in Parkinson's Disease and Therapeutic Considerations.Journal of Parkinson's disease, , Volume: 12, Issue:7, 2022
Microgliosis and neuronal proteinopathy in brain persist beyond viral clearance in SARS-CoV-2 hamster model.EBioMedicine, , Volume: 79, 2022
GM1 ganglioside modifies microglial and neuroinflammatory responses to α-synuclein in the rat AAV-A53T α-synuclein model of Parkinson's disease.Molecular and cellular neurosciences, , Volume: 120, 2022
Central and Peripheral Inflammation: Connecting the Immune Responses of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
Evidence for immune system alterations in peripheral biological fluids in Parkinson's disease.Neurobiology of disease, , Volume: 170, 2022
New Insights and Implications of Natural Killer Cells in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
Cholecystokinin and glucagon-like peptide-1 analogues regulate intestinal tight junction, inflammation, dopaminergic neurons and α-synuclein accumulation in the colon of two Parkinson's disease mouse models.European journal of pharmacology, , Jul-05, Volume: 926, 2022
Neuroinflammation in Parkinson's Disease and its Treatment Opportunities.Balkan medical journal, , 09-09, Volume: 39, Issue:5, 2022
Fucosylated Chondroitin Sulfate against Parkinson's Disease through Inhibiting Inflammation Induced by Gut Dysbiosis.Journal of agricultural and food chemistry, , Oct-26, Volume: 70, Issue:42, 2022
Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD.Molecular neurodegeneration, , 09-05, Volume: 17, Issue:1, 2022
Human gut microbiota and Parkinson's disease.Progress in molecular biology and translational science, , Volume: 192, Issue:1, 2022
Xanthotoxin modulates oxidative stress, inflammation, and MAPK signaling in a rotenone-induced Parkinson's disease model.Life sciences, , Dec-01, Volume: 310, 2022
Leveraging the preformed fibril model to distinguish between alpha-synuclein inclusion- and nigrostriatal degeneration-associated immunogenicity.Neurobiology of disease, , Volume: 171, 2022
Alpha-synuclein increases in rodent and human spinal cord injury and promotes inflammation and tissue loss.Scientific reports, , 06-03, Volume: 11, Issue:1, 2021
EphA1 Activation Induces Neuropathological Changes in a Mouse Model of Parkinson's Disease Through the CXCL12/CXCR4 Signaling Pathway.Molecular neurobiology, , Volume: 58, Issue:3, 2021
Fatal attraction - The role of hypoxia when alpha-synuclein gets intimate with mitochondria.Neurobiology of aging, , Volume: 107, 2021
Tat-p27 Ameliorates Neuronal Damage Reducing α-Synuclein and Inflammatory Responses in Motor Neurons After Spinal Cord Ischemia.Neurochemical research, , Volume: 46, Issue:12, 2021
Inflammation and Parkinson's disease pathogenesis: Mechanisms and therapeutic insight.Progress in molecular biology and translational science, , Volume: 177, 2021
Metabotropic glutamate receptor 5 inhibits α-synuclein-induced microglia inflammation to protect from neurotoxicity in Parkinson's disease.Journal of neuroinflammation, , Jan-18, Volume: 18, Issue:1, 2021
The role of innate immunity and inflammation in Parkinson´s disease.Scandinavian journal of immunology, , Volume: 93, Issue:5, 2021
The Alpha-Synuclein RT-QuIC Products Generated by the Olfactory Mucosa of Patients with Parkinson's Disease and Multiple System Atrophy Induce Inflammatory Responses in SH-SY5Y Cells.Cells, , 12-28, Volume: 11, Issue:1, 2021
Velvet Antler Methanol Extracts Ameliorate Parkinson's Disease by Inhibiting Oxidative Stress and Neuroinflammation: From Oxidative medicine and cellular longevity, , Volume: 2021, 2021
Pursuing Multiple Biomarkers for Early Idiopathic Parkinson's Disease Diagnosis.Molecular neurobiology, , Volume: 58, Issue:11, 2021
NLRP3 Inflammasome Inhibition Prevents α-Synuclein Pathology by Relieving Autophagy Dysfunction in Chronic MPTP-Treated NLRP3 Knockout Mice.Molecular neurobiology, , Volume: 58, Issue:4, 2021
Further Characterization of Intrastriatal Lipopolysaccharide Model of Parkinson's Disease in C57BL/6 Mice.International journal of molecular sciences, , Jul-09, Volume: 22, Issue:14, 2021
Peripheral inflammation exacerbates α-synuclein toxicity and neuropathology in Parkinson's models.Neuropathology and applied neurobiology, , Volume: 47, Issue:1, 2021
The Contribution of Microglia to Neuroinflammation in Parkinson's Disease.International journal of molecular sciences, , Apr-28, Volume: 22, Issue:9, 2021
Inflammation in Experimental Models of α-Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:1, 2021
The Nigral Coup in Parkinson's Disease by α-Synuclein and Its Associated Rebels.Cells, , 03-09, Volume: 10, Issue:3, 2021
The Intersection of Parkinson's Disease, Viral Infections, and COVID-19.Molecular neurobiology, , Volume: 58, Issue:9, 2021
Genetic and Environmental Factors in Parkinson's Disease Converge on Immune Function and Inflammation.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:1, 2021
Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes.Cell, , 09-30, Volume: 184, Issue:20, 2021
Alpha-Synuclein-induced DNA Methylation and Gene Expression in Microglia.Neuroscience, , 08-01, Volume: 468, 2021
High-salt diet does not boost neuroinflammation and neurodegeneration in a model of α-synucleinopathy.Journal of neuroinflammation, , Jan-24, Volume: 17, Issue:1, 2020
Modeling Parkinson's Disease Neuropathology and Symptoms by Intranigral Inoculation of Preformed Human α-Synuclein Oligomers.International journal of molecular sciences, , Nov-12, Volume: 21, Issue:22, 2020
Immunotherapy for Parkinson's disease.Neurobiology of disease, , Volume: 137, 2020
Parkinson's disease and the gastrointestinal microbiome.Journal of neurology, , Volume: 267, Issue:9, 2020
A new avenue for treating Parkinson's disease targeted at aggrephagy modulation and neuroinflammation: Insights from in vitro and animal studies.EBioMedicine, , Volume: 51, 2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disease.International journal of molecular sciences, , Nov-10, Volume: 21, Issue:22, 2020
Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models.Journal of neuroinflammation, , Jul-17, Volume: 17, Issue:1, 2020
Alpha sinuclein expression in blood and its relationship with chronic constipation in a population from Bogotá, D.C., with problems of alcohol consumptionBiomedica : revista del Instituto Nacional de Salud, , 06-15, Volume: 40, Issue:2, 2020
Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease.The Journal of clinical investigation, , 08-03, Volume: 130, Issue:8, 2020
Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD.Proceedings of the National Academy of Sciences of the United States of America, , 06-30, Volume: 117, Issue:26, 2020
FTY720-Mitoxy reduces synucleinopathy and neuroinflammation, restores behavior and mitochondria function, and increases GDNF expression in Multiple System Atrophy mouse models.Experimental neurology, , Volume: 325, 2020
A novel multi-marker discovery approach identifies new serum biomarkers for Parkinson's disease in older people: an EXosomes in PArkiNson Disease (EXPAND) ancillary study.GeroScience, , Volume: 42, Issue:5, 2020
Apoptosis signal regulating kinase 1 deletion mitigates α-synuclein pre-formed fibril propagation in mice.Neurobiology of aging, , Volume: 85, 2020
Prodromal Intestinal Events in Alzheimer's Disease (AD): Colonic Dysmotility and Inflammation Are Associated with Enteric AD-Related Protein Deposition.International journal of molecular sciences, , May-15, Volume: 21, Issue:10, 2020
Bioluminescence Imaging of Neuroinflammation in a Mouse Model of Parkinson's Disease.Methods in molecular biology (Clifton, N.J.), , Volume: 2081, 2020
CMT-3 targets different α-synuclein aggregates mitigating their toxic and inflammogenic effects.Scientific reports, , 11-20, Volume: 10, Issue:1, 2020
Preferential microglial activation associated with pathological alpha synuclein transmission.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, , Volume: 81, 2020
Biomarkers for Parkinson's Disease: How Good Are They?Neuroscience bulletin, , Volume: 36, Issue:2, 2020
Discoidin Domain Receptor 1 is a therapeutic target for neurodegenerative diseases.Human molecular genetics, , 10-10, Volume: 29, Issue:17, 2020
Biological links between traumatic brain injury and Parkinson's disease.Acta neuropathologica communications, , 04-07, Volume: 8, Issue:1, 2020
Mechanisms of alpha-synuclein toxicity: An update and outlook.Progress in brain research, , Volume: 252, 2020
Korean Red Ginseng Regulates Intestinal Tight Junction and Inflammation in the Colon of a Parkinson's Disease Mouse Model.Journal of medicinal food, , Volume: 23, Issue:12, 2020
The gut microbiome in Parkinson's disease: A culprit or a bystander?Progress in brain research, , Volume: 252, 2020
The Promise and Challenges of Developing miRNA-Based Therapeutics for Parkinson's Disease.Cells, , 03-31, Volume: 9, Issue:4, 2020
The Role of α-Synuclein Oligomers in Parkinson's Disease.International journal of molecular sciences, , Nov-17, Volume: 21, Issue:22, 2020
Gut Microbiome Imbalance and Neuroinflammation: Impact of COVID-19 on Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:9, 2020
Neuron-Astrocyte Interactions in Parkinson's Disease.Cells, , 12-07, Volume: 9, Issue:12, 2020
What and How Can Physical Activity Prevention Function on Parkinson's Disease?Oxidative medicine and cellular longevity, , Volume: 2020, 2020
Effects of Grape Polyphenols on the Life Span and Neuroinflammatory Alterations Related to Neurodegenerative Parkinson Disease-Like Disturbances in Mice.Molecules (Basel, Switzerland), , Nov-16, Volume: 25, Issue:22, 2020
Isotope-reinforced polyunsaturated fatty acids improve Parkinson's disease-like phenotype in rats overexpressing α-synuclein.Acta neuropathologica communications, , 12-11, Volume: 8, Issue:1, 2020
Manganese Accumulation in the Brain via Various Transporters and Its Neurotoxicity Mechanisms.Molecules (Basel, Switzerland), , Dec-12, Volume: 25, Issue:24, 2020
Double-stranded RNA-induced dopaminergic neuronal loss in the substantia nigra in the presence of Mac1 receptor.Biochemical and biophysical research communications, , 12-17, Volume: 533, Issue:4, 2020
Iron Dysregulation and Inflammagens Related to Oral and Gut Health Are Central to the Development of Parkinson's Disease.Biomolecules, , 12-29, Volume: 11, Issue:1, 2020
Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils.Neurobiology of disease, , Volume: 129, 2019
Histamine-4 receptor antagonist JNJ7777120 inhibits pro-inflammatory microglia and prevents the progression of Parkinson-like pathology and behaviour in a rat model.Brain, behavior, and immunity, , Volume: 76, 2019
Autoimmunity in Parkinson's Disease: The Role of α-Synuclein-Specific T Cells.Frontiers in immunology, , Volume: 10, 2019
Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease.Annals of neurology, , Volume: 86, Issue:4, 2019
Temporal evolution of microglia and α-synuclein accumulation following foetal grafting in Parkinson's disease.Brain : a journal of neurology, , 06-01, Volume: 142, Issue:6, 2019
Nurr1: A vital participant in the TLR4-NF-κB signal pathway stimulated by α-synuclein in BV-2 cells.Neuropharmacology, , Volume: 144, 2019
Lentivirus-mediated downregulation of α-synuclein reduces neuroinflammation and promotes functional recovery in rats with spinal cord injury.Journal of neuroinflammation, , Dec-30, Volume: 16, Issue:1, 2019
Novel Immunotherapeutic Approaches to Target Alpha-Synuclein and Related Neuroinflammation in Parkinson's Disease.Cells, , 01-31, Volume: 8, Issue:2, 2019
TREM2 deficiency aggravates α-synuclein-induced neurodegeneration and neuroinflammation in Parkinson's disease models.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 33, Issue:11, 2019
Acute inflammation down-regulates alpha-synuclein expression in enteric neurons.Journal of neurochemistry, , Volume: 148, Issue:6, 2019
CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson's disease.Journal of neuroinflammation, , Dec-12, Volume: 16, Issue:1, 2019
Lycopodium Attenuates Loss of Dopaminergic Neurons by Suppressing Oxidative Stress and Neuroinflammation in a Rat Model of Parkinson's Disease.Molecules (Basel, Switzerland), , Jun-10, Volume: 24, Issue:11, 2019
Parkinson's disease: a short story of 200 years.Histology and histopathology, , Volume: 34, Issue:6, 2019
Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson's disease.Journal of neuroinflammation, , Jul-22, Volume: 16, Issue:1, 2019
[Research progress on neural mechanism of peripheral inflammation in Parkinson's disease].Sheng li xue bao : [Acta physiologica Sinica], , Oct-25, Volume: 71, Issue:5, 2019
Calpain in the cleavage of alpha-synuclein and the pathogenesis of Parkinson's disease.Progress in molecular biology and translational science, , Volume: 167, 2019
Microglia in Parkinson's Disease.Advances in experimental medicine and biology, , Volume: 1175, 2019
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miR-let-7a suppresses α-Synuclein-induced microglia inflammation through targeting STAT3 in Parkinson's disease.Biochemical and biophysical research communications, , 11-19, Volume: 519, Issue:4, 2019
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D-Ala2-GIP-glu-PAL is neuroprotective in a chronic Parkinson's disease mouse model and increases BNDF expression while reducing neuroinflammation and lipid peroxidation.European journal of pharmacology, , Feb-15, Volume: 797, 2017
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Spermine protects alpha-synuclein expressing dopaminergic neurons from manganese-induced degeneration.Cell biology and toxicology, , Volume: 35, Issue:2, 2019
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Nigral depigmentation reflects monoamine exhaustion as initial step to Parkinson's disease.Medical hypotheses, , Volume: 110, 2018
MANF protects dopamine neurons and locomotion defects from a human α-synuclein induced Parkinson's disease model in C. elegans by regulating ER stress and autophagy pathways.Experimental neurology, , Volume: 308, 2018
A Focus on the Beneficial Effects of Alpha Synuclein and a Re-Appraisal of Synucleinopathies.Current protein & peptide science, , Volume: 19, Issue:6, 2018
Modeling Parkinson's Disease in C. elegans.Journal of Parkinson's disease, , Volume: 8, Issue:1, 2018
Limited effects of dysfunctional macroautophagy on the accumulation of extracellularly derived α-synuclein in oligodendroglia: implications for MSA pathogenesis.BMC neuroscience, , 05-21, Volume: 19, Issue:1, 2018
α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton.Neuron, , 01-03, Volume: 97, Issue:1, 2018
Synapsin III deficiency hampers α-synuclein aggregation, striatal synaptic damage and nigral cell loss in an AAV-based mouse model of Parkinson's disease.Acta neuropathologica, , Volume: 136, Issue:4, 2018
Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 06-19, Volume: 115, Issue:25, 2018
Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation.Molecular neurodegeneration, , 08-09, Volume: 13, Issue:1, 2018
Holothuria scabra extracts exhibit anti-Parkinson potential in C. elegans: A model for anti-Parkinson testing.Nutritional neuroscience, , Volume: 21, Issue:6, 2018
Decelerated neurodegeneration after intravitreal injection of α-synuclein antibodies in a glaucoma animal model.Scientific reports, , 07-24, Volume: 7, Issue:1, 2017
Allelic difference in Mhc2ta confers altered microglial activation and susceptibility to α-synuclein-induced dopaminergic neurodegeneration.Neurobiology of disease, , Volume: 106, 2017
Protein aggregation and neurodegeneration in prototypical neurodegenerative diseases: Examples of amyloidopathies, tauopathies and synucleinopathies.Progress in neurobiology, , Volume: 155, 2017
The implication of neuronimmunoendocrine (NIE) modulatory network in the pathophysiologic process of Parkinson's disease.Cellular and molecular life sciences : CMLS, , Volume: 74, Issue:20, 2017
Brain monoamine oxidase B and A in human parkinsonian dopamine deficiency disorders.Brain : a journal of neurology, , Sep-01, Volume: 140, Issue:9, 2017
Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice.Neuron, , Nov-15, Volume: 96, Issue:4, 2017
Propagation of pathological α-synuclein in marmoset brain.Acta neuropathologica communications, , Feb-02, Volume: 5, Issue:1, 2017
DT-diaphorase Protects Against Autophagy Induced by Aminochrome-Dependent Alpha-Synuclein Oligomers.Neurotoxicity research, , Volume: 32, Issue:3, 2017
Interaction of LRRK2 and α-Synuclein in Parkinson's Disease.Advances in neurobiology, , Volume: 14, 2017
Sorbus alnifolia protects dopaminergic neurodegeneration in Caenorhabditis elegans.Pharmaceutical biology, , Volume: 55, Issue:1, 2017
Lewy Bodies and the Mechanisms of Neuronal Cell Death in Parkinson's Disease and Dementia with Lewy Bodies.Brain pathology (Zurich, Switzerland), , Volume: 27, Issue:1, 2017
AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson's disease.Acta neuropathologica communications, , Feb-01, Volume: 5, Issue:1, 2017
Neuronal Loss and Α-Synuclein Pathology in the Superior Colliculus and Its Relationship to Visual Hallucinations in Dementia with Lewy Bodies.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, , Volume: 25, Issue:6, 2017
Progression of alpha-synuclein pathology in multiple system atrophy of the cerebellar type.Neuropathology and applied neurobiology, , Volume: 43, Issue:4, 2017
α-Synuclein-carrying extracellular vesicles in Parkinson's disease: deadly transmitters.Acta neurologica Belgica, , Volume: 117, Issue:1, 2017
α-Mangostin Inhibits α-Synuclein-Induced Microglial Neuroinflammation and Neurotoxicity.Cellular and molecular neurobiology, , Volume: 36, Issue:5, 2016
α-Synuclein in Extracellular Vesicles: Functional Implications and Diagnostic Opportunities.Cellular and molecular neurobiology, , Volume: 36, Issue:3, 2016
Fenpropathrin, a Widely Used Pesticide, Causes Dopaminergic Degeneration.Molecular neurobiology, , Volume: 53, Issue:2, 2016
Synphilin-1 attenuates mutant LRRK2-induced neurodegeneration in Parkinson's disease models.Human molecular genetics, , Feb-15, Volume: 25, Issue:4, 2016
Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson's Disease Patients.Cell reports, , 06-14, Volume: 15, Issue:11, 2016
Post-translational modifications of α-synuclein contribute to neurodegeneration in the colon of elderly individuals.Molecular medicine reports, , Volume: 13, Issue:6, 2016
DNA damage preceding dopamine neuron degeneration in A53T human α-synuclein transgenic mice.Biochemical and biophysical research communications, , Dec-02, Volume: 481, Issue:1-2, 2016
α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.Human molecular genetics, , Mar-15, Volume: 25, Issue:6, 2016
Aberrant adenosine A2A receptor signaling contributes to neurodegeneration and cognitive impairments in a mouse model of synucleinopathy.Experimental neurology, , Volume: 283, Issue:Pt A, 2016
Interactions of GFAP with ceftriaxone and phenytoin: SRCD and molecular docking and dynamic simulation.Biochimica et biophysica acta, , Volume: 1860, Issue:10, 2016
Glia and alpha-synuclein in neurodegeneration: A complex interaction.Neurobiology of disease, , Volume: 85, 2016
Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats.Autophagy, , Volume: 12, Issue:11, 2016
Neurodegeneration in tauopathies and synucleinopathies.Revue neurologique, , Volume: 172, Issue:11, 2016
α-Synuclein induced toxicity in brain stem serotonin neurons mediated by an AAV vector driven by the tryptophan hydroxylase promoter.Scientific reports, , 05-23, Volume: 6, 2016
Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation.The Journal of cell biology, , 09-12, Volume: 214, Issue:6, 2016
Caspase-1 clipping causes complications for α-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , Sep-06, Volume: 113, Issue:36, 2016
Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration.PLoS genetics, , Volume: 12, Issue:3, 2016
Phosphorylated α-synuclein in skin nerve fibres differentiates Parkinson's disease from multiple system atrophy.Brain : a journal of neurology, , Volume: 138, Issue:Pt 8, 2015
Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration.Molecular neurodegeneration, , 06-23, Volume: 10, 2015
LK6/Mnk2a is a new kinase of alpha synuclein phosphorylation mediating neurodegeneration.Scientific reports, , Jul-29, Volume: 5, 2015
Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative.Neurobiology of disease, , Volume: 80, 2015
Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration.Neurobiology of disease, , Volume: 82, 2015
Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain.The Journal of neuroscience : the official journal of the Society for Neuroscience, , May-27, Volume: 35, Issue:21, 2015
PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein.Acta neuropathologica communications, , Apr-01, Volume: 3, 2015
Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury.Acta neuropathologica communications, , Mar-24, Volume: 3, 2015
shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model.The Journal of clinical investigation, , Jul-01, Volume: 125, Issue:7, 2015
The Parkinson's disease-related protein DJ-1 protects dopaminergic neurons in vivo and cultured cells from alpha-synuclein and 6-hydroxydopamine toxicity.Neuro-degenerative diseases, , Volume: 15, Issue:1, 2015
X-linked Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:2, 2015
A53T human α-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jan-21, Volume: 35, Issue:3, 2015
Pathogenic mechanisms of neurodegeneration in Parkinson disease.Neurologic clinics, , Volume: 33, Issue:1, 2015
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets.Transfusion, , Volume: 55, Issue:3, 2015
Aneuploidy in Lewy body diseases.Neurobiology of aging, , Volume: 36, Issue:3, 2015
Hot, Hotter, and Hottest Trends in α-Synuclein Research.Current protein & peptide science, , Volume: 16, Issue:8, 2015
α-Synuclein Shows High Affinity Interaction with Voltage-dependent Anion Channel, Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease.The Journal of biological chemistry, , Jul-24, Volume: 290, Issue:30, 2015
Alpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons.Cell death & disease, , Jul-09, Volume: 6, 2015
Alpha-synuclein and tau: teammates in neurodegeneration?Molecular neurodegeneration, , Oct-29, Volume: 9, 2014
ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo.Molecular therapy : the journal of the American Society of Gene Therapy, , Volume: 22, Issue:10, 2014
Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys.Annals of neurology, , Volume: 75, Issue:3, 2014
Acetylcorynoline attenuates dopaminergic neuron degeneration and α-synuclein aggregation in animal models of Parkinson's disease.Neuropharmacology, , Volume: 82, 2014
Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation.The Journal of clinical investigation, , Volume: 124, Issue:7, 2014
S-Nitrosylating protein disulphide isomerase mediates α-synuclein aggregation caused by methamphetamine exposure in PC12 cells.Toxicology letters, , Oct-01, Volume: 230, Issue:1, 2014
The paths to neurodegeneration in genetic Parkinson's disease.CNS & neurological disorders drug targets, , Volume: 13, Issue:9, 2014
Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease.Neurobiology of disease, , Volume: 64, 2014
α-Synuclein A30P decreases neurodegeneration and increases synaptic vesicle release probability in CSPα-null mice.Neuropharmacology, , Volume: 76 Pt A, 2014
Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo.Brain : a journal of neurology, , Volume: 137, Issue:Pt 5, 2014
Cardiac sympathetic denervation in 6-OHDA-treated nonhuman primates.PloS one, , Volume: 9, Issue:8, 2014
Cutaneous neuropathy in Parkinson's disease: a window into brain pathology.Acta neuropathologica, , Volume: 128, Issue:1, 2014
Engineered antibody therapies coming of age for aging brains.Molecular therapy : the journal of the American Society of Gene Therapy, , Volume: 22, Issue:10, 2014
Next-generation active immunization approach for synucleinopathies: implications for Parkinson's disease clinical trials.Acta neuropathologica, , Volume: 127, Issue:6, 2014
Autophagy-lysosome pathway associated neuropathology and axonal degeneration in the brains of alpha-galactosidase A-deficient mice.Acta neuropathologica communications, , Feb-14, Volume: 2, 2014
Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease.PloS one, , Volume: 9, Issue:2, 2014
Mutations in RAB39B cause X-linked intellectual disability and early-onset Parkinson disease with α-synuclein pathology.American journal of human genetics, , Dec-04, Volume: 95, Issue:6, 2014
Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicity.Disease models & mechanisms, , Volume: 7, Issue:5, 2014
The prion hypothesis of Parkinson's disease: this hot topic just got hotter.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:8, 2014
[The role of alpha-synuclein in Parkinson's disease].Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, , Volume: 16, Issue:2, 2014
Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice.BMC neuroscience, , Nov-05, Volume: 14, 2013
β-synuclein aggregates and induces neurodegeneration in dopaminergic neurons.Annals of neurology, , Volume: 74, Issue:1, 2013
α-Synuclein oligomers and clinical implications for Parkinson disease.Annals of neurology, , Volume: 73, Issue:2, 2013
The role of Ser129 phosphorylation of α-synuclein in neurodegeneration of Parkinson's disease: a review of in vivo models.Reviews in the neurosciences, , Volume: 24, Issue:2, 2013
Alpha-synuclein pathology and axonal degeneration of the peripheral motor nerves innervating pharyngeal muscles in Parkinson disease.Journal of neuropathology and experimental neurology, , Volume: 72, Issue:2, 2013
Parkinson disease: from pathology to molecular disease mechanisms.Free radical biology & medicine, , Volume: 62, 2013
Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study.The Lancet. Neurology, , Volume: 12, Issue:5, 2013
Potential neuroprotective effect of ibuprofen, insights from the mice model of Parkinson's disease.Pharmacological reports : PR, , Volume: 65, Issue:5, 2013
MHCII is required for α-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jun-05, Volume: 33, Issue:23, 2013
α-Synuclein in CSF of patients with severe traumatic brain injury.Neurology, , Apr-30, Volume: 80, Issue:18, 2013
rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration.Molecular neurodegeneration, , Nov-25, Volume: 8, 2013
Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice.Molecular brain, , Aug-11, Volume: 6, 2013
Valproic acid ameliorates C. elegans dopaminergic neurodegeneration with implications for ERK-MAPK signaling.Neuroscience letters, , Apr-29, Volume: 541, 2013
Telmisartan attenuates MPTP induced dopaminergic degeneration and motor dysfunction through regulation of α-synuclein and neurotrophic factors (BDNF and GDNF) expression in C57BL/6J mice.Neuropharmacology, , Volume: 73, 2013
Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration.Brain : a journal of neurology, , Volume: 136, Issue:Pt 7, 2013
Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies.Journal of neurochemistry, , Volume: 125, Issue:4, 2013
Parkinson disease affects peripheral sensory nerves in the pharynx.Journal of neuropathology and experimental neurology, , Volume: 72, Issue:7, 2013
Exosomes of BV-2 cells induced by alpha-synuclein: important mediator of neurodegeneration in PD.Neuroscience letters, , Aug-26, Volume: 548, 2013
Neuronal vulnerability, pathogenesis, and Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:1, 2013
Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 27, Issue:9, 2013
Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Sep-26, Volume: 32, Issue:39, 2012
Loss of spinal motor neurons and alteration of alpha-synuclein immunostaining in MPTP induced Parkinsonism in mice.Journal of chemical neuroanatomy, , Volume: 44, Issue:2, 2012
Lysosomal dysfunction in neurodegeneration: the role of ATP13A2/PARK9.Autophagy, , Volume: 8, Issue:6, 2012
Inclusion of a portion of the native SNCA 3'UTR reduces toxicity of human S129A SNCA on striatal-projecting dopamine neurons in rat substantia nigra.Developmental neurobiology, , Volume: 72, Issue:6, 2012
The molecular basis of dopaminergic brain imaging in Parkinson's disease.The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of..., , Volume: 56, Issue:1, 2012
A proteomic analysis of MCLR-induced neurotoxicity: implications for Alzheimer's disease.Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 127, Issue:2, 2012
Comparison of the behavioural and histological characteristics of the 6-OHDA and α-synuclein rat models of Parkinson's disease.Experimental neurology, , Volume: 235, Issue:1, 2012
Synaptic dysfunction in Parkinson's disease.Advances in experimental medicine and biology, , Volume: 970, 2012
Emerging neurotoxic mechanisms in environmental factors-induced neurodegeneration.Neurotoxicology, , Volume: 33, Issue:4, 2012
Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of α-synucleinopathy.Experimental neurology, , Volume: 234, Issue:2, 2012
Animal models of multiple system atrophy.Neuroscience, , Jun-01, Volume: 211, 2012
Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function.Human molecular genetics, , Apr-15, Volume: 21, Issue:8, 2012
Synaptic protein alterations in Parkinson's disease.Molecular neurobiology, , Volume: 45, Issue:1, 2012
Myeloperoxidase inhibition ameliorates multiple system atrophy-like degeneration in a transgenic mouse model.Neurotoxicity research, , Volume: 21, Issue:4, 2012
α-Synuclein synaptic pathology and its implications in the development of novel therapeutic approaches to cure Parkinson's disease.Brain research, , Jan-13, Volume: 1432, 2012
Extensive distribution of glial cytoplasmic inclusions in an autopsied case of multiple system atrophy with a prolonged 18-year clinical course.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 32, Issue:1, 2012
Melatonin reduces the expression of alpha-synuclein in the dopamine containing neuronal regions of amphetamine-treated postnatal rats.Journal of pineal research, , Volume: 52, Issue:1, 2012
Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity.Human molecular genetics, , Sep-01, Volume: 21, Issue:17, 2012
Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain.The Journal of neuroscience : the official journal of the Society for Neuroscience, , May-30, Volume: 32, Issue:22, 2012
Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jul-04, Volume: 32, Issue:27, 2012
In vivo alterations in calcium buffering capacity in transgenic mouse model of synucleinopathy.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jul-18, Volume: 32, Issue:29, 2012
α-Synuclein disrupts stress signaling by inhibiting polo-like kinase Cdc5/Plk2.Proceedings of the National Academy of Sciences of the United States of America, , Oct-02, Volume: 109, Issue:40, 2012
Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease.Environmental health perspectives, , Volume: 119, Issue:6, 2011
Increased iron levels correlate with the selective nigral dopaminergic neuron degeneration in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 118, Issue:3, 2011
Caenorhabditis elegans as an experimental tool for the study of complex neurological diseases: Parkinson's disease, Alzheimer's disease and autism spectrum disorder.Invertebrate neuroscience : IN, , Volume: 11, Issue:2, 2011
Measurement of proteasomal dysfunction in cell models of dopaminergic degeneration.Methods in molecular biology (Clifton, N.J.), , Volume: 758, 2011
Glutathione depletion and overproduction both initiate degeneration of nigral dopaminergic neurons.Acta neuropathologica, , Volume: 121, Issue:4, 2011
Synphilin suppresses α-synuclein neurotoxicity in a Parkinson's disease Drosophila model.Genesis (New York, N.Y. : 2000), , Volume: 49, Issue:5, 2011
α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jul-06, Volume: 31, Issue:27, 2011
Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applications.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:8, 2011
Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease.PloS one, , Apr-29, Volume: 6, Issue:4, 2011
Parkin-mediated protection of dopaminergic neurons in a chronic MPTP-minipump mouse model of Parkinson disease.Journal of neuropathology and experimental neurology, , Volume: 70, Issue:8, 2011
Melittin restores proteasome function in an animal model of ALS.Journal of neuroinflammation, , Jun-20, Volume: 8, 2011
Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death.Neuron, , Oct-06, Volume: 72, Issue:1, 2011
Tau-positive glial cytoplasmic granules in multiple system atrophy.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 31, Issue:3, 2011
Chronic exposure to manganese decreases striatal dopamine turnover in human alpha-synuclein transgenic mice.Neuroscience, , Apr-28, Volume: 180, 2011
[Multiple system atrophy - synuclein and neuronal degeneration].Rinsho shinkeigaku = Clinical neurology, , Volume: 51, Issue:11, 2011
Alpha-synuclein loss in spinal muscular atrophy.Journal of molecular neuroscience : MN, , Volume: 43, Issue:3, 2011
Cerebrospinal fluid from patients with multiple system atrophy promotes in vitro α-synuclein fibril formation.Neuroscience letters, , Mar-10, Volume: 491, Issue:1, 2011
Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease.Disease models & mechanisms, , Volume: 4, Issue:5, 2011
Differential regional expression patterns of α-synuclein, TNF-α, and IL-1β; and variable status of dopaminergic neurotoxicity in mouse brain after Paraquat treatment.Journal of neuroinflammation, , Nov-24, Volume: 8, 2011
Drug targets from genetics: α-synuclein.CNS & neurological disorders drug targets, , Sep-01, Volume: 10, Issue:6, 2011
Pros and cons of a prion-like pathogenesis in Parkinson's disease.BMC neurology, , Jun-20, Volume: 11, 2011
α-Synuclein deficiency and efferent nerve degeneration in the mouse cochlea: a possible cause of early-onset presbycusis.Neuroscience research, , Volume: 71, Issue:3, 2011
Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis.The American journal of pathology, , Volume: 179, Issue:5, 2011
Progressive neurodegeneration or endogenous compensation in an animal model of Parkinson's disease produced by decreasing doses of alpha-synuclein.PloS one, , Mar-07, Volume: 6, Issue:3, 2011
Spinal cord and parkinsonism: neuromorphological evidences in humans and experimental studies.Journal of chemical neuroanatomy, , Volume: 42, Issue:4, 2011
Degeneration of dopaminergic neurons induced by thrombin injection in the substantia nigra of the rat is enhanced by dexamethasone: role of monoamine oxidase enzyme.Neurotoxicology, , Volume: 31, Issue:1, 2010
Synergistic effects of environmental risk factors and gene mutations in Parkinson's disease accelerate age-related neurodegeneration.Journal of neurochemistry, , Volume: 115, Issue:6, 2010
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.Science (New York, N.Y.), , Sep-24, Volume: 329, Issue:5999, 2010
Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model.Human molecular genetics, , Jun-01, Volume: 19, Issue:11, 2010
Neurodegeneration in a transgenic mouse model of multiple system atrophy is associated with altered expression of oligodendroglial-derived neurotrophic factors.The Journal of neuroscience : the official journal of the Society for Neuroscience, , May-05, Volume: 30, Issue:18, 2010
Alpha-synuclein disrupted dopamine homeostasis leads to dopaminergic neuron degeneration in Caenorhabditis elegans.PloS one, , Feb-19, Volume: 5, Issue:2, 2010
Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy.PloS one, , Feb-19, Volume: 5, Issue:2, 2010
α-Synuclein expression in rat substantia nigra suppresses phospholipase D2 toxicity and nigral neurodegeneration.Molecular therapy : the journal of the American Society of Gene Therapy, , Volume: 18, Issue:10, 2010
Vulnerability of peripheral catecholaminergic neurons to MPTP is not regulated by alpha-synuclein.Neurobiology of disease, , Volume: 38, Issue:1, 2010
Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-17, Volume: 30, Issue:7, 2010
Drosophila histone deacetylase 6 protects dopaminergic neurons against {alpha}-synuclein toxicity by promoting inclusion formation.Molecular biology of the cell, , Jul-01, Volume: 21, Issue:13, 2010
Over-expression of alpha-synuclein in the nervous system enhances axonal degeneration after peripheral nerve lesion in a transgenic mouse strain.Journal of neurochemistry, , Volume: 114, Issue:4, 2010
Astrocytic expression of Parkinson's disease-related A53T alpha-synuclein causes neurodegeneration in mice.Molecular brain, , Apr-21, Volume: 3, 2010
Dysfunctional mitochondria uphold calpain activation: contribution to Parkinson's disease pathology.Neurobiology of disease, , Volume: 37, Issue:3, 2010
Hsp70 molecular chaperones and Parkinson's disease.Biopolymers, , Volume: 93, Issue:3, 2010
Neuroscience and heart-brain medicine: the year in review.Cleveland Clinic journal of medicine, , Volume: 77 Suppl 3, 2010
VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease.Neurobiology of disease, , Volume: 37, Issue:2, 2010
A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death.Neurobiology of aging, , Volume: 31, Issue:1, 2010
Ageing, neurodegeneration and Parkinson's disease.Age and ageing, , Volume: 39, Issue:2, 2010
Upregulation of alpha-synuclein expression in the rat cerebellum in experimental hepatic encephalopathy.Neuropathology and applied neurobiology, , Volume: 36, Issue:5, 2010
Neuropathological asymmetry in argyrophilic grain disease.Journal of neuropathology and experimental neurology, , Volume: 69, Issue:7, 2010
Effects of UCH-L1 on alpha-synuclein over-expression mouse model of Parkinson's disease.Journal of neurochemistry, , Volume: 108, Issue:4, 2009
A chemical chaperone, sodium 4-phenylbutyric acid, attenuates the pathogenic potency in human alpha-synuclein A30P + A53T transgenic mice.Parkinsonism & related disorders, , Volume: 15, Issue:9, 2009
Unique copper-induced oligomers mediate alpha-synuclein toxicity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 23, Issue:8, 2009
Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Oct-28, Volume: 29, Issue:43, 2009
Striatal neuroinflammation promotes Parkinsonism in rats.PloS one, , Volume: 4, Issue:5, 2009
Degeneration in different parkinsonian syndromes relates to astrocyte type and astrocyte protein expression.Journal of neuropathology and experimental neurology, , Volume: 68, Issue:10, 2009
Subchronic infusion of the product of inflammation prostaglandin J2 models sporadic Parkinson's disease in mice.Journal of neuroinflammation, , Jul-25, Volume: 6, 2009
Neurodegeneration in Parkinson's disease: genetics enlightens physiopathology.Journal of neural transmission. Supplementum, , Issue:73, 2009
Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-18, Volume: 29, Issue:7, 2009
Neuroprotective effect of the antiparkinsonian drug pramipexole against nigrostriatal dopaminergic degeneration in rotenone-treated mice.Neurochemistry international, , Volume: 55, Issue:8, 2009
The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson's disease.Journal of neurochemistry, , Volume: 110, Issue:1, 2009
The ALS/PDC syndrome of Guam and the cycad hypothesis.Neurology, , Feb-03, Volume: 72, Issue:5, 2009
Differences between subacute and chronic MPTP mice models: investigation of dopaminergic neuronal degeneration and alpha-synuclein inclusions.Journal of neurochemistry, , Volume: 109, Issue:5, 2009
Common key-signals in learning and neurodegeneration: focus on excito-amino acids, beta-amyloid peptides and alpha-synuclein.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 116, Issue:8, 2009
Association of alpha-synuclein immunoreactivity with inflammatory activity in multiple sclerosis lesions.Journal of neuropathology and experimental neurology, , Volume: 68, Issue:2, 2009
Relative preservation of thalamic centromedian nucleus in parkinsonian patients with dystonia.Movement disorders : official journal of the Movement Disorder Society, , Oct-30, Volume: 24, Issue:14, 2009
Parkinsonism in hiv-infected patients on highly active antiretroviral therapy.Neurology, , Aug-04, Volume: 73, Issue:5, 2009
alpha-synuclein and LRRK2: partners in crime.Neuron, , Dec-24, Volume: 64, Issue:6, 2009
Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.Neuron, , Dec-24, Volume: 64, Issue:6, 2009
[Mechanism of neuronal degeneration of multiple system atrophy].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 61, Issue:9, 2009
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Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip.The EMBO journal, , Dec-02, Volume: 28, Issue:23, 2009
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Transgenic mice with human mutant genes causing Parkinson's disease and amyotrophic lateral sclerosis provide common insight into mechanisms of motor neuron selective vulnerability to degeneration.Reviews in the neurosciences, , Volume: 18, Issue:2, 2007
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Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat.Neurobiology of disease, , Volume: 20, Issue:1, 2005
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Immunotherapeutic Approaches for the Treatment of Neurodegenerative Diseases: Challenges and Outcomes.CNS & neurological disorders drug targets, , Volume: 22, Issue:3, 2023
α-Synuclein Aggregates in the Nigro-Striatal Dopaminergic Pathway Impair Fine Movement: Partial Reversal by the Adenosine AInternational journal of molecular sciences, , Jan-10, Volume: 24, Issue:2, 2023
MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson's disease.Molecular neurodegeneration, , Dec-01, Volume: 18, Issue:1, 2023
Enhanced mTORC1 signaling and protein synthesis in pathologic α-synuclein cellular and animal models of Parkinson's disease.Science translational medicine, , Nov-29, Volume: 15, Issue:724, 2023
Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson's disease in rodent brains.Molecular neurodegeneration, , Nov-27, Volume: 18, Issue:1, 2023
aSynPEP-DB: a database of biogenic peptides for inhibiting α-synuclein aggregation.Database : the journal of biological databases and curation, , 11-27, Volume: 2023, 2023
[no title available]Gut microbes, , Volume: 15, Issue:2, 2023
Nucleation of α-Synuclein Amyloid Fibrils Induced by Cross-Interaction with β-Hairpin Peptides Derived from Immunoglobulin Light Chains.International journal of molecular sciences, , Nov-09, Volume: 24, Issue:22, 2023
Neuronal SNCA transcription during Lewy body formation.Acta neuropathologica communications, , 11-23, Volume: 11, Issue:1, 2023
Brain-to-gut trafficking of alpha-synuclein by CD11cNature communications, , Nov-20, Volume: 14, Issue:1, 2023
Polymorphic USP8 allele promotes Parkinson's disease by inducing the accumulation of α-synuclein through deubiquitination.Cellular and molecular life sciences : CMLS, , Nov-19, Volume: 80, Issue:12, 2023
Anionic nanoplastic contaminants promote Parkinson's disease-associated α-synuclein aggregation.Science advances, , 11-15, Volume: 9, Issue:46, 2023
Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores.Journal of the American Chemical Society, , Nov-29, Volume: 145, Issue:47, 2023
Anethole attenuates motor dysfunctions, striatal neuronal activity deficiency and blood brain barrier permeability by decreasing striatal α-synuclein and oxidative stress in rotenone-induced Parkinson's disease of male rats.PloS one, , Volume: 18, Issue:11, 2023
Polysorbate 80 surface modified SLNs of formoterol suppress SNCA gene and mitochondrial oxidative stress in mice model of Parkinson's disease.Scientific reports, , 11-15, Volume: 13, Issue:1, 2023
Co-aggregation of α-synuclein with amyloid-β stabilizes β-sheet-rich oligomers and enhances the formation of β-barrels.Physical chemistry chemical physics : PCCP, , Nov-29, Volume: 25, Issue:46, 2023
Transmembrane β-Barrel Models of α-Synuclein Oligomers.Journal of chemical information and modeling, , Nov-27, Volume: 63, Issue:22, 2023
Photo-oxygenation of histidine residue inhibits α-synuclein aggregation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 37, Issue:12, 2023
Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson's disease mouse model.Nature communications, , 11-13, Volume: 14, Issue:1, 2023
Formoterol attenuated mitochondrial dysfunction in rotenone-induced Parkinson's disease in a rat model: Role of PINK-1/PARKIN and PI3K/Akt/CREB/BDNF/TrKB axis.International immunopharmacology, , Volume: 125, Issue:Pt B, 2023
Probing physical properties of single amyloid fibrils using nanofluidic channels.Nanoscale, , Nov-30, Volume: 15, Issue:46, 2023
Aggregation of alpha-synuclein disrupts mitochondrial metabolism and induce mitophagy via cardiolipin externalization.Cell death & disease, , 11-10, Volume: 14, Issue:11, 2023
Single-Molecule Detection of α-Synuclein Oligomers in Parkinson's Disease Patients Using Nanopores.ACS nano, , 11-28, Volume: 17, Issue:22, 2023
Peptide-based approaches to directly target alpha-synuclein in Parkinson's disease.Molecular neurodegeneration, , Nov-09, Volume: 18, Issue:1, 2023
Cholestanol accelerates α-synuclein aggregation and spreading by activating asparagine endopeptidase.JCI insight, , Nov-08, Volume: 8, Issue:21, 2023
Characterization of Molecular Tweezer Binding on α-Synuclein with Native Top-Down Mass Spectrometry and Ion Mobility-Mass Spectrometry Reveals a Mechanism for Aggregation Inhibition.Journal of the American Society for Mass Spectrometry, , Dec-06, Volume: 34, Issue:12, 2023
Antagonizing pathological α-synuclein-mediated neurodegeneration by J24335 via the activation of immunoproteasome.Toxicology and applied pharmacology, , Dec-01, Volume: 480, 2023
Distinct molecular mechanisms contribute to the reduction of melanoma growth and tumor pain after systemic and local depletion of alpha-Synuclein in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 37, Issue:12, 2023
Synaptotagmin-11 regulates immune functions of microglia in vivo.Journal of neurochemistry, , Volume: 167, Issue:5, 2023
Conformational dynamics of α-synuclein and study of its intramolecular forces in the presence of selected compounds.Scientific reports, , 11-03, Volume: 13, Issue:1, 2023
SARS-CoV-2 N-protein induces the formation of composite α-synuclein/N-protein fibrils that transform into a strain of α-synuclein fibrils.Nanoscale, , Nov-23, Volume: 15, Issue:45, 2023
[no title available]Biomolecular NMR assignments, , Volume: 17, Issue:2, 2023
Modulation of Alpha-Synuclein Conformational Ensemble and Aggregation Pathways by Dopamine and Related Molecules.Frontiers in bioscience (Landmark edition), , 10-26, Volume: 28, Issue:10, 2023
The yeast prion protein Sup35 initiates α-synuclein pathology in mouse models of Parkinson's disease.Science advances, , 11-03, Volume: 9, Issue:44, 2023
Alpha-Synuclein-Specific Regulatory T Cells Ameliorate Parkinson's Disease Progression in Mice.International journal of molecular sciences, , Oct-16, Volume: 24, Issue:20, 2023
The Effects of Lipids on α-Synuclein Aggregation In Vitro.Biomolecules, , 10-02, Volume: 13, Issue:10, 2023
Autophagy in Parkinson's Disease.Biomolecules, , 09-22, Volume: 13, Issue:10, 2023
The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases.Nature communications, , 10-27, Volume: 14, Issue:1, 2023
Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering.Proceedings of the National Academy of Sciences of the United States of America, , Oct-31, Volume: 120, Issue:44, 2023
Citrus Flavonoid Hesperetin Inhibits α-Synuclein Fibrillogenesis, Disrupts Mature Fibrils, and Reduces Their Cytotoxicity: In Vitro and In Vivo Studies.Journal of agricultural and food chemistry, , Nov-01, Volume: 71, Issue:43, 2023
Dynamic reversibility of α-synuclein serine-129 phosphorylation is impaired in synucleinopathy models.EMBO reports, , Dec-06, Volume: 24, Issue:12, 2023
Tau accumulation in degradative organelles is associated to lysosomal stress.Scientific reports, , 10-21, Volume: 13, Issue:1, 2023
α-synuclein seed amplification in Parkinson's disease.The Lancet. Neurology, , Volume: 22, Issue:11, 2023
α-synuclein seed amplification in Parkinson's disease - Authors' reply.The Lancet. Neurology, , Volume: 22, Issue:11, 2023
α-synuclein seed amplification in Parkinson's disease.The Lancet. Neurology, , Volume: 22, Issue:11, 2023
α-synuclein seed amplification in Parkinson's disease.The Lancet. Neurology, , Volume: 22, Issue:11, 2023
Oligomeric and Fibrillar α-Synuclein Display Persistent Dynamics and Compressibility under Controlled Confinement.ACS chemical neuroscience, , 11-01, Volume: 14, Issue:21, 2023
Synuclein Seed Amplification in the Cerebrospinal Fluid: Research and Clinical Implications.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:11, 2023
Identifying Current pharmaceutical design, , Volume: 29, Issue:30, 2023
Inactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson's disease.Scientific reports, , 10-18, Volume: 13, Issue:1, 2023
The interplay between α-Synuclein and NLRP3 inflammasome in Parkinson's disease.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 168, 2023
α-Synuclein propagation leads to synaptic abnormalities in the cortex through microglial synapse phagocytosis.Molecular brain, , 10-17, Volume: 16, Issue:1, 2023
Lipoproteins and α-synuclein in cerebrospinal fluid in Parkinson's disease: "Dangerous liaisons" on the road to neurodegeneration?Parkinsonism & related disorders, , Volume: 116, 2023
The interaction between alpha-synuclein and mitochondrial dysfunction in Parkinson's disease.Biophysical chemistry, , Volume: 303, 2023
α-Synuclein-dependent increases in PIP5K1γ drive inositol signaling to promote neurotoxicity.Cell reports, , 10-31, Volume: 42, Issue:10, 2023
Retinal Changes in Parkinson's Disease: A Non-invasive Biomarker for Early Diagnosis.Cellular and molecular neurobiology, , Volume: 43, Issue:8, 2023
Kinetic parameters of alpha-synuclein seed amplification assay correlate with cognitive impairment in patients with Lewy body disorders.Acta neuropathologica communications, , 10-09, Volume: 11, Issue:1, 2023
Measuring Constipation in a Drosophila Model of Parkinson's Disease.Journal of visualized experiments : JoVE, , 09-22, Issue:199, 2023
Identifying the potential genes in alpha synuclein driving ferroptosis of Parkinson's disease.Scientific reports, , 10-06, Volume: 13, Issue:1, 2023
Feasibility of combining alpha-synuclein aggregation and 6-OHDA in embryonic midbrain culture for modeling dopamine neuron degeneration.Neuroscience letters, , 11-01, Volume: 816, 2023
Misfolded α-Synuclein in Cerebrospinal Fluid of Contact Sport Athletes.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:11, 2023
α-Synuclein induces deficiency in clathrin-mediated endocytosis through inhibiting synaptojanin1 expression.Journal of neurochemistry, , Volume: 167, Issue:3, 2023
Nanowired delivery of dl-3-n-butylphthalide with antibodies to alpha synuclein potentiated neuroprotection in Parkinson's disease with emotional stress.International review of neurobiology, , Volume: 171, 2023
Imaging Protein Aggregates in Parkinson's Disease Serum Using Aptamer-Assisted Single-Molecule Pull-Down.Analytical chemistry, , 10-17, Volume: 95, Issue:41, 2023
Stable isotope labeling and ultra-high-resolution NanoSIMS imaging reveal alpha-synuclein-induced changes in neuronal metabolism in vivo.Acta neuropathologica communications, , 09-29, Volume: 11, Issue:1, 2023
Neuromelanin accumulation drives endogenous synucleinopathy in non-human primates.Brain : a journal of neurology, , Dec-01, Volume: 146, Issue:12, 2023
A Novel NOX Inhibitor Alleviates Parkinson's Disease Pathology in PFF-Injected Mice.International journal of molecular sciences, , Sep-19, Volume: 24, Issue:18, 2023
The Avidity of Autoreactive Alpha-Synuclein Antibodies in Leucine-Rich Repeat Kinase 2 Mutation Carriers Is Not Altered Compared to Healthy Controls or Patients with Parkinson's Disease.Biomolecules, , 08-25, Volume: 13, Issue:9, 2023
Syringin Prevents 6-Hydroxydopamine Neurotoxicity by Mediating the MiR-34a/SIRT1/Beclin-1 Pathway and Activating Autophagy in SH-SY5Y Cells and the Cells, , 09-19, Volume: 12, Issue:18, 2023
Nuclear localization of alpha-synuclein induces anxiety-like behavior in mice by decreasing hippocampal neurogenesis and pathologically affecting amygdala circuits.Neuroscience letters, , 11-01, Volume: 816, 2023
Ferroptosis in Parkinson's disease: Molecular mechanisms and therapeutic potential.Ageing research reviews, , Volume: 91, 2023
Peptide immunization against the C-terminal of alpha-synuclein reduces locomotor activity in mice overexpressing alpha-synuclein.PloS one, , Volume: 18, Issue:9, 2023
The neuroprotective effects of FG-4592, a hypoxia-inducible factor-prolyl hydroxylase inhibitor, against oxidative stress induced by alpha-synuclein in N2a cells.Scientific reports, , 09-20, Volume: 13, Issue:1, 2023
The C-terminus of α-Synuclein Regulates its Dynamic Cellular Internalization by Neurexin 1β.Molecular biology of the cell, , Dec-01, Volume: 34, Issue:13, 2023
A fruit extract of Styphnolobium japonicum (L.) counteracts oxidative stress and mediates neuroprotection in Caenorhabditis elegans.BMC complementary medicine and therapies, , Sep-19, Volume: 23, Issue:1, 2023
Investigating the potential effects of α-synuclein aggregation on susceptibility to chronic stress in a mouse Parkinson's disease model.Pharmacological reports : PR, , Volume: 75, Issue:6, 2023
Elevated concentrations cause upright alpha-synuclein conformation at lipid interfaces.Nature communications, , 09-18, Volume: 14, Issue:1, 2023
Low-dose Cu exposure enhanced α-synuclein accumulation associates with mitochondrial impairments in mice model of Parkinson's disease.Toxicology letters, , Sep-15, Volume: 387, 2023
Viral-like TLR3 induction of cytokine networks and α-synuclein are reduced by complement C3 blockade in mouse brain.Scientific reports, , 09-13, Volume: 13, Issue:1, 2023
Cross-Linked α-Synuclein as Inhibitor of Amyloid Formation.International journal of molecular sciences, , Aug-29, Volume: 24, Issue:17, 2023
Uncovering the Role of Natural and Synthetic Small Molecules in Counteracting the Burden of α-Synuclein Aggregates and Related Toxicity in Different Models of Parkinson's Disease.International journal of molecular sciences, , Aug-29, Volume: 24, Issue:17, 2023
The Bidirectional Interplay of α-Synuclein with Lipids in the Central Nervous System and Its Implications for the Pathogenesis of Parkinson's Disease.International journal of molecular sciences, , Aug-26, Volume: 24, Issue:17, 2023
Beyond Strains: Molecular Diversity in Alpha-Synuclein at the Center of Disease Heterogeneity.International journal of molecular sciences, , Aug-25, Volume: 24, Issue:17, 2023
TFEB regulates cellular labile iron and prevents ferroptosis in a TfR1-dependent manner.Free radical biology & medicine, , 11-01, Volume: 208, 2023
6-hydroxydopamine affects multiple pathways to induce cytotoxicity in differentiated LUHMES dopaminergic neurons.Neurochemistry international, , Volume: 170, 2023
Fiber deprivation and microbiome-borne curli shift gut bacterial populations and accelerate disease in a mouse model of Parkinson's disease.Cell reports, , 09-26, Volume: 42, Issue:9, 2023
A small molecule 20C from Gastrodia elata inhibits α-synuclein aggregation and prevents progression of Parkinson's disease.Cell death & disease, , 09-06, Volume: 14, Issue:9, 2023
A selective ER-phagy exerts neuroprotective effects via modulation of α-synuclein clearance in parkinsonian models.Proceedings of the National Academy of Sciences of the United States of America, , 09-12, Volume: 120, Issue:37, 2023
Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease.Journal of cellular and molecular medicine, , Volume: 27, Issue:22, 2023
Structure specific neuro-toxicity of α-synuclein oligomer.International journal of biological macromolecules, , Dec-31, Volume: 253, Issue:Pt 1, 2023
Monovalent cations have different effects on the assembly kinetics and morphology of α-synuclein amyloid fibrils.Biochemical and biophysical research communications, , 10-30, Volume: 679, 2023
A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibrils in Multiple System Atrophy.Journal of medicinal chemistry, , 09-14, Volume: 66, Issue:17, 2023
Association between regular physical activity and biomarker changes in early Parkinson's disease patients.Parkinsonism & related disorders, , Volume: 115, 2023
Distinct impacts of alpha-synuclein overexpression on the hippocampal epigenome of mice in standard and enriched environments.Neurobiology of disease, , 10-01, Volume: 186, 2023
Distinct Patterns of Gene Expression Changes in the Colon and Striatum of Young Mice Overexpressing Alpha-Synuclein Support Parkinson's Disease as a Multi-System Process.Journal of Parkinson's disease, , Volume: 13, Issue:7, 2023
Association between SGK1 and α-synuclein in skeletal muscle in an MPTP-induced Parkinson's disease model.Neuroscience letters, , 09-25, Volume: 814, 2023
Amyloids of α-Synuclein Promote Chemical Transformations of Neuronal Cell Metabolites.International journal of molecular sciences, , Aug-16, Volume: 24, Issue:16, 2023
Aggregation-Inhibiting scFv-Based Therapies Protect Mice against AAV1/2-Induced A53T-α-Synuclein Overexpression.Biomolecules, , 07-31, Volume: 13, Issue:8, 2023
Membrane phospholipid peroxidation promotes loss of dopaminergic neurons in psychological stress-induced Parkinson's disease susceptibility.Aging cell, , Volume: 22, Issue:10, 2023
α-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis.Translational neurodegeneration, , 08-25, Volume: 12, Issue:1, 2023
Calcineurin stimulation by Cnb1p overproduction mitigates protein aggregation and α-synuclein toxicity in a yeast model of synucleinopathy.Cell communication and signaling : CCS, , 08-24, Volume: 21, Issue:1, 2023
Fiber-Specific White Matter Alterations in Parkinson's Disease Patients with GBA Gene Mutations.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:11, 2023
Meta-analysis to Implement Alpha-Synuclein in Extracellular Vesicles as a Potential Biomarker for Parkinsons Disease.Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion, , Volume: 75, Issue:4, 2023
Developmental exposure to the Parkinson's disease-associated organochlorine pesticide dieldrin alters dopamine neurotransmission in α-synuclein pre-formed fibril (PFF)-injected mice.Toxicological sciences : an official journal of the Society of Toxicology, , Oct-30, Volume: 196, Issue:1, 2023
Effects of ozone treatment to the levels of neurodegeneration biomarkers after rotenone induced rat model of Parkinson's disease.Neuroscience letters, , 09-25, Volume: 814, 2023
The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis.Molecular medicine (Cambridge, Mass.), , 08-18, Volume: 29, Issue:1, 2023
27-Hydroxycholesterol Drives the Spread of α-Synuclein Pathology in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:11, 2023
Seed amplification assay results illustrate discrepancy in Parkinson's disease clinical diagnostic accuracy and error rates.Journal of neurology, , Volume: 270, Issue:12, 2023
Mutant α-synuclein propagates via the lymphatic system of the brain in the monomeric state.Cell reports, , 08-29, Volume: 42, Issue:8, 2023
A Fixable Fluorescence-Quenched Substrate for Quantitation of Lysosomal Glucocerebrosidase Activity in Both Live and Fixed Cells.Angewandte Chemie (International ed. in English), , 10-02, Volume: 62, Issue:40, 2023
Coumarin-chalcone hybrid LM-021 and indole derivative NC009-1 targeting inflammation and oxidative stress to protect BE(2)-M17 cells against α-synuclein toxicity.Aging, , 08-11, Volume: 15, Issue:16, 2023
Effect of flavonoids on the destabilization of α-synuclein fibrils and their conversion to amorphous aggregate: A molecular dynamics simulation and experimental study.Biochimica et biophysica acta. Proteins and proteomics, , 11-01, Volume: 1871, Issue:6, 2023
Comparison of biospecimens for α-synuclein seed amplification assays in Parkinson's disease: A systematic review and network meta-analysis.European journal of neurology, , Volume: 30, Issue:12, 2023
Acetylated α-Tubulin and α-Synuclein: Physiological Interplay and Contribution to α-Synuclein Oligomerization.International journal of molecular sciences, , Jul-31, Volume: 24, Issue:15, 2023
α-Synuclein Strains and Their Relevance to Parkinson's Disease, Multiple System Atrophy, and Dementia with Lewy Bodies.International journal of molecular sciences, , Jul-28, Volume: 24, Issue:15, 2023
Investigation of Inflammation in Lewy Body Dementia: A Systematic Scoping Review.International journal of molecular sciences, , Jul-28, Volume: 24, Issue:15, 2023
Neuroprotective effects of osmotin in Parkinson's disease-associated pathology via the AdipoR1/MAPK/AMPK/mTOR signaling pathways.Journal of biomedical science, , Aug-11, Volume: 30, Issue:1, 2023
The variance in phosphorylated, insoluble ⍺-synuclein in humans, rats, and mice is not mainly driven by biological sex.Acta neuropathologica, , Volume: 146, Issue:4, 2023
Implications of In Vitro Multi-Serine Phosphorylation of Alpha-Synuclein in Aggregation and Cytotoxicity.ACS chemical neuroscience, , 09-06, Volume: 14, Issue:17, 2023
Combined measure of salivary alpha-synuclein species as diagnostic biomarker for Parkinson's disease.Journal of neurology, , Volume: 270, Issue:11, 2023
Combining non-canonical amino acid mutagenesis and native chemical ligation for multiply modifying proteins: A case study of α-synuclein post-translational modifications.Methods (San Diego, Calif.), , Volume: 218, 2023
Understanding the effect of the membrane-mimetic micelles on the interplay between α-synuclein and Cu(II)/Cu(I) cations.Journal of inorganic biochemistry, , Volume: 247, 2023
VPS35 and α-Synuclein fail to interact to modulate neurodegeneration in rodent models of Parkinson's disease.Molecular neurodegeneration, , 08-04, Volume: 18, Issue:1, 2023
How should we be using biomarkers in trials of disease modification in Parkinson's disease?Brain : a journal of neurology, , Dec-01, Volume: 146, Issue:12, 2023
Combating Dopaminergic Neurodegeneration in Parkinson's Disease through Nanovesicle Technology.ACS chemical neuroscience, , 08-16, Volume: 14, Issue:16, 2023
The Involvement of Progranulin for α-Synuclein Reduction through Autolysosome Formation.Biological & pharmaceutical bulletin, , Volume: 46, Issue:8, 2023
Omics Analyses in a Neural Stem Cell Model of Familial Parkinson's Disease.Advances in experimental medicine and biology, , Volume: 1423, 2023
Non-invasive Monitoring of α-Synuclein in Saliva for Parkinson's Disease Using Organic Electrolyte-Gated FET Aptasensor.ACS sensors, , 08-25, Volume: 8, Issue:8, 2023
Pharmacological interventions targeting α-synuclein aggregation triggered REM sleep behavior disorder and early development of Parkinson's disease.Pharmacology & therapeutics, , Volume: 249, 2023
E46K Mutation of α-Synuclein Preorganizes the Intramolecular Interactions Crucial for Aggregation.Journal of chemical information and modeling, , 08-14, Volume: 63, Issue:15, 2023
Blood-Based α-Synuclein Seeding-A New Era for Identifying Parkinsonian Syndromes.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:8, 2023
Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer.Archives of biochemistry and biophysics, , Volume: 744, 2023
4-Oxo-2-nonenal-Induced α-Synuclein Oligomers Interact with Membranes in the Cell, Leading to Mitochondrial Fragmentation.Biochemistry, , 08-15, Volume: 62, Issue:16, 2023
Alpha-synuclein fibrils amplified from multiple system atrophy and Parkinson's disease patient brain spread after intracerebral injection into mouse brain.Brain pathology (Zurich, Switzerland), , Volume: 33, Issue:5, 2023
Co-administration of Nanowired DL-3-n-Butylphthalide (DL-NBP) Together with Mesenchymal Stem Cells, Monoclonal Antibodies to Alpha Synuclein and TDP-43 (TAR DNA-Binding Protein 43) Enhance Superior Neuroprotection in Parkinson's Disease Following ConcussiAdvances in neurobiology, , Volume: 32, 2023
Nanodelivery of Histamine H3/H4 Receptor Modulators BF-2649 and Clobenpropit with Antibodies to Amyloid Beta Peptide in Combination with Alpha Synuclein Reduces Brain Pathology in Parkinson's Disease.Advances in neurobiology, , Volume: 32, 2023
Elevated ApoE, ApoJ and lipoprotein-bound α-synuclein levels in cerebrospinal fluid from Parkinson's disease patients - Validation in the BioFIND cohort.Parkinsonism & related disorders, , Volume: 116, 2023
Lessons and future directions for GBA1-targeting therapies.The Lancet. Neurology, , Volume: 22, Issue:8, 2023
Alpha-synuclein in skin as a high-quality biomarker for Parkinson's disease.Journal of the neurological sciences, , 08-15, Volume: 451, 2023
Impaired aldehyde detoxification exacerbates motor deficits in an alpha-synuclein mouse model of Parkinson's disease.Brain and behavior, , Volume: 13, Issue:9, 2023
Parallel neurodegenerative phenotypes in sporadic Parkinson's disease fibroblasts and midbrain dopamine neurons.Progress in neurobiology, , Volume: 229, 2023
Extracellular Vesicles for the Diagnosis of Parkinson's Disease: Systematic Review and Meta-Analysis.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:9, 2023
Are Therapies That Target α-Synuclein Effective at Halting Parkinson's Disease Progression? A Systematic Review.International journal of molecular sciences, , Jul-03, Volume: 24, Issue:13, 2023
Brain-Biomarker Changes in Body Fluids of Patients with Parkinson's Disease.International journal of molecular sciences, , Jun-30, Volume: 24, Issue:13, 2023
Probing Gut Participation in Parkinson's Disease Pathology and Treatment via Stem Cell Therapy.International journal of molecular sciences, , Jun-25, Volume: 24, Issue:13, 2023
ARL6IP5 Ameliorates α-Synuclein Burden by Inducing Autophagy via Preventing Ubiquitination and Degradation of ATG12.International journal of molecular sciences, , Jun-22, Volume: 24, Issue:13, 2023
IL-1β/IL-1R1 signaling is involved in the propagation of α-synuclein pathology of the gastrointestinal tract to the brain.Journal of neurochemistry, , Volume: 166, Issue:5, 2023
How oxidized EGCG remodels α-synuclein fibrils into non-toxic aggregates: insights from computational simulations.Physical chemistry chemical physics : PCCP, , Jul-19, Volume: 25, Issue:28, 2023
Gut-to-brain spreading of pathology in synucleinopathies: A focus on molecular signalling mediators.Behavioural brain research, , 08-24, Volume: 452, 2023
More than meets the eye in Parkinson's disease and other synucleinopathies: from proteinopathy to lipidopathy.Acta neuropathologica, , Volume: 146, Issue:3, 2023
SYNJ1 rescues motor functions in hereditary and sporadic Parkinson's disease mice by upregulating TSP-1 expression.Behavioural brain research, , 08-24, Volume: 452, 2023
Evaluation of α-synuclein in CNS-originating extracellular vesicles for Parkinsonian disorders: A systematic review and meta-analysis.CNS neuroscience & therapeutics, , Volume: 29, Issue:12, 2023
The investigation of interaction and chaperon-like activity of α-synuclein as a protein in pathophysiology of Parkinson's disease upon direct interaction with tectorigenin.International journal of biological macromolecules, , Sep-30, Volume: 249, 2023
SARS-COV-2 spike protein fragment eases amyloidogenesis of α-synuclein.The Journal of chemical physics, , Jul-07, Volume: 159, Issue:1, 2023
Toll-like Receptor 4 Is Upregulated in Parkinson's Disease Patients and Co-Localizes with pSer129αSyn: A Possible Link with the Pathology.Cells, , 05-11, Volume: 12, Issue:10, 2023
Intramolecular interaction kinetically regulates fibril formation by human and mouse α-synuclein.Scientific reports, , 07-05, Volume: 13, Issue:1, 2023
Hippocampal synaptic failure is an early event in experimental parkinsonism with subtle cognitive deficit.Brain : a journal of neurology, , Dec-01, Volume: 146, Issue:12, 2023
Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease.Molecular neurodegeneration, , 07-04, Volume: 18, Issue:1, 2023
Collaborative plasma biomarkers for Parkinson disease development and progression: A cross-sectional and longitudinal study.European journal of neurology, , Volume: 30, Issue:10, 2023
Seed Amplification Assay as a Diagnostic Tool in Newly-Diagnosed Parkinson's Disease.Journal of Parkinson's disease, , Volume: 13, Issue:5, 2023
Endocytic pathways of pathogenic protein aggregates in neurodegenerative diseases.Traffic (Copenhagen, Denmark), , Volume: 24, Issue:10, 2023
α-Synuclein seeding activity in duodenum biopsies from Parkinson's disease patients.PLoS pathogens, , Volume: 19, Issue:6, 2023
Discrimination between Alpha-Synuclein Protein Variants with a Single Nanometer-Scale Pore.ACS chemical neuroscience, , 07-19, Volume: 14, Issue:14, 2023
Sex and Age Differences in a Progressive Synucleinopathy Mouse Model.Biomolecules, , 06-11, Volume: 13, Issue:6, 2023
Three-dimensional neuroimmune co-culture system for modeling Parkinson's disease microenvironmentsBiofabrication, , 07-10, Volume: 15, Issue:4, 2023
Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of Parkinson disease.Nature communications, , 06-26, Volume: 14, Issue:1, 2023
Parkinson's disease-linked V15A mutation facilitates α-synuclein aggregation by reducing membrane affinity.Protein science : a publication of the Protein Society, , Volume: 32, Issue:8, 2023
Ultrastiff Amyloid-Fibril Network of α-Synuclein Formed by Surface Seeding Reaction Confirmed by Multichannel Electrodeless Quartz-Crystal-Microbalance Biosensor.ACS sensors, , 07-28, Volume: 8, Issue:7, 2023
Targeted degradation of ⍺-synuclein aggregates in Parkinson's disease using the AUTOTAC technology.Molecular neurodegeneration, , Jun-24, Volume: 18, Issue:1, 2023
Pharmacologic inhibition of NLRP3 reduces the levels of α-synuclein and protects dopaminergic neurons in a model of Parkinson's disease.Journal of neuroinflammation, , Jun-22, Volume: 20, Issue:1, 2023
Nigral Pathology Contributes to Microstructural Integrity of Striatal and Frontal Tracts in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:9, 2023
Transcriptomic profiling of Parkinson's disease brains reveals disease stage specific gene expression changes.Acta neuropathologica, , Volume: 146, Issue:2, 2023
α-Synuclein and biological membranes: the danger of loving too much.Chemical communications (Cambridge, England), , Jul-13, Volume: 59, Issue:57, 2023
Advanced human iPSC-based preclinical model for Parkinson's disease with optogenetic alpha-synuclein aggregation.Cell stem cell, , Jul-06, Volume: 30, Issue:7, 2023
Mass photometric detection and quantification of nanoscale α-synuclein phase separation.Nature chemistry, , Volume: 15, Issue:9, 2023
Generation of TWO G51D SNCA missense mutation iPSC lines (CRICKi011-A, CRICKi012-A) from two individuals at risk of Parkinson's disease.Stem cell research, , Volume: 71, 2023
GM1 oligosaccharide efficacy against α-synuclein aggregation and toxicity in vitro.Biochimica et biophysica acta. Molecular and cell biology of lipids, , Volume: 1868, Issue:9, 2023
Simultaneous Determination of the Size and Shape of Single α-Synuclein Oligomers in Solution.ACS nano, , 07-11, Volume: 17, Issue:13, 2023
Semi-Synthetic CoA-α-Synuclein Constructs Trap N-Terminal Acetyltransferase NatB for Binding Mechanism Studies.Journal of the American Chemical Society, , 06-28, Volume: 145, Issue:25, 2023
Unveiling How Hydroxytyrosol Destabilizes α-Syn Oligomers Using Molecular Simulations.The journal of physical chemistry. B, , 06-29, Volume: 127, Issue:25, 2023
A 14-day pulse of PLX5622 modifies α-synucleinopathy in preformed fibril-infused aged mice of both sexes.Neurobiology of disease, , Volume: 184, 2023
The mitochondrial uncoupling effects of nitazoxanide enhances cellular autophagy and promotes the clearance of α-synuclein: Potential role of AMPK-JNK pathway.Cellular signalling, , Volume: 109, 2023
Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy models.Translational neurodegeneration, , 06-13, Volume: 12, Issue:1, 2023
METTL14 is decreased and regulates mJournal of neurochemistry, , Volume: 166, Issue:3, 2023
Unsaturated fatty acids uniquely alter aggregation rate of α-synuclein and insulin and change the secondary structure and toxicity of amyloid aggregates formed in their presence.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 37, Issue:7, 2023
Microglial LRRK2-mediated NFATc1 attenuates α-synuclein immunotoxicity in association with CX3CR1-induced migration and the lysosome-initiated degradation.Glia, , Volume: 71, Issue:9, 2023
Neutrophil-to-lymphocyte ratio and lymphocyte count reflect alterations in central neurodegeneration-associated proteins and clinical severity in Parkinson Disease patients.Parkinsonism & related disorders, , Volume: 112, 2023
Truncation or proteolysis of α-synuclein in Parkinsonism.Ageing research reviews, , Volume: 90, 2023
Parkinson's Disease: A Tale of Many Players.Medical principles and practice : international journal of the Kuwait University, Health Science Centre, , Volume: 32, Issue:3, 2023
The loss of function GBA1 c.231C > G mutation associated with Parkinson disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 130, Issue:7, 2023
Sortilin acts as an endocytic receptor for α-synuclein fibril.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 37, Issue:7, 2023
Single-cell transcriptomics identifies perturbed molecular pathways in midbrain organoids using α-synuclein triplication Parkinson's disease patient-derived iPSCs.Neuroscience research, , Volume: 195, 2023
Nigrostriatal 6-hydroxydopamine lesions increase alpha-synuclein levels and permeability in rat colon.Neurobiology of aging, , Volume: 129, 2023
RAGE Against the Glycation Machine in Synucleinopathies: Time to Explore New Questions.Journal of Parkinson's disease, , Volume: 13, Issue:5, 2023
Association of Cortical Gyrification With Imaging and Serum Biomarkers in Patients With Parkinson Disease.Neurology, , 07-18, Volume: 101, Issue:3, 2023
Single-dose intranasal administration of α-syn PFFs induce lewy neurite-like pathology in olfactory bulbs.Parkinsonism & related disorders, , Volume: 112, 2023
Alpha-synuclein-associated changes in PINK1-PRKN-mediated mitophagy are disease context dependent.Brain pathology (Zurich, Switzerland), , Volume: 33, Issue:5, 2023
Targeting Sigma-1 Receptor: A Promising Strategy in the Treatment of Parkinson's Disease.Neurochemical research, , Volume: 48, Issue:10, 2023
Necrosulfonamide exerts neuroprotective effect by inhibiting necroptosis, neuroinflammation, and α-synuclein oligomerization in a subacute MPTP mouse model of Parkinson's disease.Scientific reports, , 05-31, Volume: 13, Issue:1, 2023
Disruption of α-Synuclein Proteostasis in the Striatum and Midbrain of Long-term Ovariectomized Female Mice.Neuroscience, , 07-15, Volume: 523, 2023
Dissecting the Self-assembly Dynamics of Imperfect Repeats in α-Synuclein.Journal of chemical information and modeling, , 06-12, Volume: 63, Issue:11, 2023
Phosphorylation of α-synuclein at T64 results in distinct oligomers and exerts toxicity in models of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 06-06, Volume: 120, Issue:23, 2023
Intestinal infection triggers mitochondria-mediated α-synuclein pathology: relevance to Parkinson's disease.Cellular and molecular life sciences : CMLS, , May-30, Volume: 80, Issue:6, 2023
Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α-Synuclein Mouse Models of Parkinson's Disease.Journal of medicinal chemistry, , 06-08, Volume: 66, Issue:11, 2023
Propagative α-synuclein seeds as serum biomarkers for synucleinopathies.Nature medicine, , Volume: 29, Issue:6, 2023
Parkinson's disease in a patient with olfactory hypoplasia: a model case of "body-first Lewy body disease" providing insights into the progression of α-synuclein accumulation.Journal of neurology, , Volume: 270, Issue:10, 2023
Alpha-synuclein and the Parkinson's disease drug pipeline.Parkinsonism & related disorders, , Volume: 111, 2023
Parkinson's Disease: Exploring Different Animal Model Systems.International journal of molecular sciences, , May-22, Volume: 24, Issue:10, 2023
Oligomeric Alpha-Synuclein and STX-1A from Neural-Derived Extracellular Vesicles (NDEVs) as Possible Biomarkers of REM Sleep Behavior Disorder in Parkinson's Disease: A Preliminary Cohort Study.International journal of molecular sciences, , May-16, Volume: 24, Issue:10, 2023
Asymmetric Presynaptic Depletion of Dopamine Neurons in a International journal of molecular sciences, , May-11, Volume: 24, Issue:10, 2023
Serum and Exosomal miR-7-1-5p and miR-223-3p as Possible Biomarkers for Parkinson's Disease.Biomolecules, , 05-19, Volume: 13, Issue:5, 2023
Distinct Effects of Familial Parkinson's Disease-Associated Mutations on α-Synuclein Phase Separation and Amyloid Aggregation.Biomolecules, , 04-23, Volume: 13, Issue:5, 2023
Generation of gene-corrected isogenic controls from Parkinson's disease patient iPSC lines carrying the pathogenic SNCA p.A53T variant.Stem cell research, , Volume: 69, 2023
Uncovering Novel Therapeutic Targets for Parkinson's Disease.ACS chemical neuroscience, , 06-07, Volume: 14, Issue:11, 2023
NF-κB/NLRP3 inflammasome axis and risk of Parkinson's disease in Type 2 diabetes mellitus: A narrative review and new perspective.Journal of cellular and molecular medicine, , Volume: 27, Issue:13, 2023
Retina-to-brain spreading of α-synuclein after intravitreal injection of preformed fibrils.Acta neuropathologica communications, , 05-20, Volume: 11, Issue:1, 2023
How Toll-like receptors influence Parkinson's disease in the microbiome-gut-brain axis.Frontiers in immunology, , Volume: 14, 2023
Galectin-3 shapes toxic alpha-synuclein strains in Parkinson's disease.Acta neuropathologica, , Volume: 146, Issue:1, 2023
Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity.PLoS genetics, , Volume: 19, Issue:5, 2023
Microglia-specific knock-out of NF-κB/IKK2 increases the accumulation of misfolded α-synuclein through the inhibition of p62/sequestosome-1-dependent autophagy in the rotenone model of Parkinson's disease.Glia, , Volume: 71, Issue:9, 2023
Research Progress of α-Synuclein Aggregation Inhibitors for Potential Parkinson's Disease Treatment.Mini reviews in medicinal chemistry, , Volume: 23, Issue:20, 2023
[no title available]Frontiers in cellular and infection microbiology, , Volume: 13, 2023
Impact of sex on neuroimmune contributions to Parkinson's disease.Brain research bulletin, , Volume: 199, 2023
Response to Comment on "Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice".Science translational medicine, , 05-17, Volume: 15, Issue:696, 2023
Naphthoquinone-dopamine hybrids disrupt α-synuclein fibrils by their intramolecular synergistic interactions with fibrils and display a better effect on fibril disruption.Physical chemistry chemical physics : PCCP, , May-24, Volume: 25, Issue:20, 2023
The α-Synuclein Monomer May Have Different Misfolding Mechanisms in the Induction of α-Synuclein Fibrils with Different Polymorphs.Biomolecules, , 04-17, Volume: 13, Issue:4, 2023
Alpha-Synuclein mRNA Level Found Dependent on L444P Variant in Carriers and Gaucher Disease Patients on Enzyme Replacement Therapy.Biomolecules, , 04-03, Volume: 13, Issue:4, 2023
A RaPID Macrocyclic Peptide That Inhibits the Formation of α-Synuclein Amyloid Fibrils.Chembiochem : a European journal of chemical biology, , 06-15, Volume: 24, Issue:12, 2023
Midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons.The Journal of clinical investigation, , 05-15, Volume: 133, Issue:10, 2023
Advances in understanding the function of alpha-synuclein: implications for Parkinson's disease.Brain : a journal of neurology, , 09-01, Volume: 146, Issue:9, 2023
Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats.Cell death & disease, , 05-13, Volume: 14, Issue:5, 2023
Synucleinopathies Take Their Toll: Are TLRs a Way to Go?Cells, , 04-24, Volume: 12, Issue:9, 2023
Neuropathology of incidental Lewy body & prodromal Parkinson's disease.Molecular neurodegeneration, , 05-12, Volume: 18, Issue:1, 2023
Retinoic Acid Prevents α-Synuclein Preformed Fibrils-Induced Toxicity via Inhibiting STAT1-PARP1 Signaling.Molecular neurobiology, , Volume: 60, Issue:8, 2023
The heterogeneity of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 130, Issue:6, 2023
Inhibition of p38α MAPK restores neuronal p38γ MAPK and ameliorates synaptic degeneration in a mouse model of DLB/PD.Science translational medicine, , 05-10, Volume: 15, Issue:695, 2023
Apoptotic Factors and Mitochondrial Complexes Assist Determination of Strain-Specific Susceptibility of Mice to Parkinsonian Neurotoxin MPTP.Molecular neurobiology, , Volume: 60, Issue:8, 2023
Dopamine-Induced Oligomers of α-Synuclein Inhibit Amyloid Fibril Growth and Show No Toxicity.ACS chemical neuroscience, , 06-07, Volume: 14, Issue:11, 2023
In situ continuous Dopa supply by responsive artificial enzyme for the treatment of Parkinson's disease.Nature communications, , 05-09, Volume: 14, Issue:1, 2023
An amphiphilic material arginine-arginine-bile acid promotes α-synuclein amyloid formation.Nanoscale, , Jun-01, Volume: 15, Issue:21, 2023
The Endotoxin Hypothesis of Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:7, 2023
Endophytic Fusarium species, a unique bioresource for disaggregator of misfolded alpha-synuclein.Archives of microbiology, , May-08, Volume: 205, Issue:6, 2023
Islet amyloid polypeptide triggers α-synuclein pathology in Parkinson's disease.Progress in neurobiology, , Volume: 226, 2023
The Endo-lysosomal System in Parkinson's Disease: Expanding the Horizon.Journal of molecular biology, , 06-15, Volume: 435, Issue:12, 2023
Impact of APOE Genotype on Cognition in Idiopathic and Genetic Forms of Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:5, 2023
Involvement of Abnormal p-α-syn Accumulation and TLR2-Mediated Inflammation of Schwann Cells in Enteric Autonomic Nerve Dysfunction of Parkinson's Disease: an Animal Model Study.Molecular neurobiology, , Volume: 60, Issue:8, 2023
The Parkinson's disease-associated protein α-synuclein inhibits hepatoma by exosome delivery.Molecular carcinogenesis, , Volume: 62, Issue:8, 2023
Autophagy‑regulating miRNAs: Novel therapeutic targets for Parkinson's disease (Review).International journal of molecular medicine, , Volume: 51, Issue:6, 2023
The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson's disease.Acta neuropathologica communications, , 05-03, Volume: 11, Issue:1, 2023
Fluid and Biopsy Based Biomarkers in Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 20, Issue:4, 2023
Mechanistic Insights into Polyphenols' Aggregation Inhibition of α-Synuclein and Related Peptides.ACS chemical neuroscience, , 05-17, Volume: 14, Issue:10, 2023
Experimental models of gut-first Parkinson's disease: A systematic review.Neurogastroenterology and motility, , Volume: 35, Issue:8, 2023
LPS-induced mitochondrial dysfunction regulates innate immunity activation and α-synuclein oligomerization in Parkinson's disease.Redox biology, , Volume: 63, 2023
Gut-to-Brain α-Synuclein Transmission in Parkinson's Disease: Evidence for Prion-like Mechanisms.International journal of molecular sciences, , Apr-13, Volume: 24, Issue:8, 2023
Pathophysiology and Neuroimmune Interactions Underlying Parkinson's Disease and Traumatic Brain Injury.International journal of molecular sciences, , Apr-13, Volume: 24, Issue:8, 2023
Revisiting Alpha-Synuclein Pathways to Inflammation.International journal of molecular sciences, , Apr-12, Volume: 24, Issue:8, 2023
Roflumilast escalates α-synuclein aggregate degradation in rotenone-induced Parkinson's disease in rats: Modulation of the ubiquitin-proteasome system and endoplasmic reticulum stress.Chemico-biological interactions, , Jul-01, Volume: 379, 2023
A seed amplification assay to detect Parkinson disease pathology.Nature reviews. Neurology, , Volume: 19, Issue:6, 2023
Naringenin-Functionalized Gold Nanoparticles and Their Role in α-Synuclein Stabilization.Langmuir : the ACS journal of surfaces and colloids, , 05-30, Volume: 39, Issue:21, 2023
Cntnap4 partial deficiency exacerbates α-synuclein pathology through astrocyte-microglia C3-C3aR pathway.Cell death & disease, , 04-22, Volume: 14, Issue:4, 2023
Targeting the GBA1 pathway to slow Parkinson disease: Insights into clinical aspects, pathogenic mechanisms and new therapeutic avenues.Pharmacology & therapeutics, , Volume: 246, 2023
Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson's disease.Nature communications, , 04-19, Volume: 14, Issue:1, 2023
Fluorescence labeling methods influence the aggregation process of α-syn Nanoscale, , May-11, Volume: 15, Issue:18, 2023
Immunological Features of LRRK2 Function and Its Role in the Gut-Brain Axis Governing Parkinson's Disease.Journal of Parkinson's disease, , Volume: 13, Issue:3, 2023
Proposal for a Biologic Staging System of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 13, Issue:3, 2023
CaMovement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:6, 2023
MALAT1 Mediates Mediators of inflammation, , Volume: 2023, 2023
Lewy bodies, iron, inflammation and neuromelanin: pathological aspects underlying Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 130, Issue:5, 2023
The brain-first vs. body-first model of Parkinson's disease with comparison to alternative models.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 130, Issue:6, 2023
Targeting α-Synuclein: A Further Viewpoint.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:4, 2023
Kinetic control in amyloid polymorphism: Different agitation and solution conditions promote distinct amyloid polymorphs of alpha-synuclein.Biochimica et biophysica acta. Proteins and proteomics, , Jul-01, Volume: 1871, Issue:4, 2023
Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional study.The Lancet. Neurology, , Volume: 22, Issue:5, 2023
α-synuclein seed amplification and its uses in Parkinson's disease.The Lancet. Neurology, , Volume: 22, Issue:5, 2023
Novel FABP3 ligand, HY-11-9, ameliorates neuropathological deficits in MPTP-induced Parkinsonism in mice.Journal of pharmacological sciences, , Volume: 152, Issue:1, 2023
Discerning Modulation of α-Synuclein Amyloid Assembly by α-Crystallin.ACS chemical neuroscience, , 05-03, Volume: 14, Issue:9, 2023
⍺-Synuclein Structural Diversity and the Cellular Environment in ⍺-Synuclein Transmission Models and Humans.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 20, Issue:1, 2023
Double-Edged Effects of Venglustat on Behavior and Pathology in Mice Overexpressing α-Synuclein.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:6, 2023
α-Synuclein Preformed Fibrils Bind to β-Neurexins and Impair β-Neurexin-Mediated Presynaptic Organization.Cells, , 04-04, Volume: 12, Issue:7, 2023
Unraveling the Complex Interplay between Alpha-Synuclein and Epigenetic Modification.International journal of molecular sciences, , Apr-02, Volume: 24, Issue:7, 2023
Effect of Electric Field on α-Synuclein Fibrils: Revealed by Molecular Dynamics Simulations.International journal of molecular sciences, , Mar-28, Volume: 24, Issue:7, 2023
Targeting neuronal lysosomal dysfunction caused by β-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct.Nature communications, , 04-12, Volume: 14, Issue:1, 2023
The cervical lymph node contributes to peripheral inflammation related to Parkinson's disease.Journal of neuroinflammation, , Apr-10, Volume: 20, Issue:1, 2023
Cognitive heterogeneity in Parkinson's disease: A mechanistic view.Neuron, , 05-17, Volume: 111, Issue:10, 2023
Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism.Nature communications, , 04-06, Volume: 14, Issue:1, 2023
Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage.Nature communications, , 04-06, Volume: 14, Issue:1, 2023
African walnut (Tetracarpidium conophorum) extract upregulates glucocerebrosidase activity and circumvents Parkinsonian changes in the Hippocampus via the activation of heatshock proteins.Journal of chemical neuroanatomy, , Volume: 130, 2023
Interfacial properties of α-synuclein's Parkinsonian variants.Biophysical chemistry, , Volume: 297, 2023
Alpha-synuclein in Parkinson's disease: a villain or tragic hero? A critical view of the formation of α-synuclein aggregates induced by dopamine metabolites and viral infection.Expert review of neurotherapeutics, , Volume: 23, Issue:4, 2023
The interplay between monocytes, α-synuclein and LRRK2 in Parkinson's disease.Biochemical Society transactions, , 04-26, Volume: 51, Issue:2, 2023
Cerebrospinal fluid lipoproteins inhibit α-synuclein aggregation by interacting with oligomeric species in seed amplification assays.Molecular neurodegeneration, , 04-01, Volume: 18, Issue:1, 2023
Non-invasive auditory and visual stimulation attenuates α-Synuclein deposition and improves motor and non-motor symptoms in PD mice.Experimental neurology, , Volume: 364, 2023
Modulation of cytotoxic amyloid fibrillation and mitochondrial damage of α-synuclein by catechols mediated conformational changes.Scientific reports, , 03-31, Volume: 13, Issue:1, 2023
Cerebrospinal fluid alpha-synuclein, amyloid beta, total tau, and phosphorylated tau in tremor-dominant Parkinson's disease.Acta neurologica Belgica, , Volume: 123, Issue:4, 2023
Identification of a Putative α-synuclein Radioligand Using an in silico Similarity Search.Molecular imaging and biology, , Volume: 25, Issue:4, 2023
Alpha Synuclein: Neurodegeneration and Inflammation.International journal of molecular sciences, , Mar-21, Volume: 24, Issue:6, 2023
Gene Expression Profiling as a Novel Diagnostic Tool for Neurodegenerative Disorders.International journal of molecular sciences, , Mar-17, Volume: 24, Issue:6, 2023
Dopamine Transmission Imbalance in Neuroinflammation: Perspectives on Long-Term COVID-19.International journal of molecular sciences, , Mar-15, Volume: 24, Issue:6, 2023
Determining the Location of the α-Synuclein Dimer Interface Using Native Top-Down Fragmentation and Isotope Depletion-Mass Spectrometry.Journal of the American Society for Mass Spectrometry, , May-03, Volume: 34, Issue:5, 2023
Central and peripheral α-synuclein in Parkinson disease detected by seed amplification assay.Annals of clinical and translational neurology, , Volume: 10, Issue:5, 2023
Sex hormones differentially contribute to Parkinson disease in males: A multimodal biomarker study.European journal of neurology, , Volume: 30, Issue:7, 2023
Small molecule-based fluorescent probes for the detection of α-Synuclein aggregation states.Bioorganic & medicinal chemistry letters, , 04-15, Volume: 86, 2023
Biochemical study of the effect of mesenchymal stem cells-derived exosome versus L-Dopa in experimentally induced Parkinson's disease in rats.Molecular and cellular biochemistry, , Volume: 478, Issue:12, 2023
Vinpocetine prevents rotenone-induced Parkinson disease motor and non-motor symptoms through attenuation of oxidative stress, neuroinflammation and α-synuclein expressions in rats.Neurotoxicology, , Volume: 96, 2023
Cannabidiol Recovers Dopaminergic Neuronal Damage Induced by Reserpine or α-synuclein in Caenorhabditis elegans.Neurochemical research, , Volume: 48, Issue:8, 2023
Activation of ROS-PERK-TFEB by filbertone ameliorates neurodegenerative diseases via enhancing the autophagy-lysosomal pathway.The Journal of nutritional biochemistry, , Volume: 118, 2023
Unexpected phenotypic and molecular changes of combined glucocerebrosidase and acid sphingomyelinase deficiency.Disease models & mechanisms, , 06-01, Volume: 16, Issue:6, 2023
Inflammasome inhibition protects dopaminergic neurons from α-synuclein pathology in a model of progressive Parkinson's disease.Journal of neuroinflammation, , Mar-21, Volume: 20, Issue:1, 2023
Inhibitory mechanism of n-MTAB AuNPs for α-synuclein aggregation.Journal of molecular modeling, , Mar-21, Volume: 29, Issue:4, 2023
Host-to-graft Propagation of α-synuclein in a Mouse Model of Parkinson's Disease: Intranigral Versus Intrastriatal Transplantation.Transplantation, , 08-01, Volume: 107, Issue:8, 2023
Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson's disease-related fibril polymorphism.Acta neuropathologica, , Volume: 145, Issue:5, 2023
Exploration and Exploitation Approaches Based on Generative Machine Learning to Identify Potent Small Molecule Inhibitors of α-Synuclein Secondary Nucleation.Journal of chemical theory and computation, , Jul-25, Volume: 19, Issue:14, 2023
Functional and neuropathological changes induced by injection of distinct alpha-synuclein strains: A pilot study in non-human primates.Neurobiology of disease, , Volume: 180, 2023
Misfolded α-Synuclein Assessment in the Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorder.Neurology, , 05-02, Volume: 100, Issue:18, 2023
Suppression of neuroinflammation and α-synuclein oligomerization by rotarod walking exercise in subacute MPTP model of Parkinson's disease.Neurochemistry international, , Volume: 165, 2023
Genetic testing for Parkinson's disease in clinical practice.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 130, Issue:6, 2023
Rose essential oil diminishes dopaminergic neuron degenerations and reduces α-synuclein aggregation in Caenorhabditis elegans models of Parkinson's disease.Phytotherapy research : PTR, , Volume: 37, Issue:7, 2023
α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies.Translational neurodegeneration, , 03-14, Volume: 12, Issue:1, 2023
Acupuncture inhibits autophagy and repairs synapses by activating the mTOR pathway in Parkinson's disease depression model rats.Brain research, , 06-01, Volume: 1808, 2023
The Role of Alpha-Synuclein Deposits in Parkinson's Disease: A Focus on the Human Retina.International journal of molecular sciences, , Feb-23, Volume: 24, Issue:5, 2023
Recent Advances in the Treatment of Genetic Forms of Parkinson's Disease: Hype or Hope?Cells, , 02-27, Volume: 12, Issue:5, 2023
Mesenchymal stem-cell-derived microvesicles ameliorate MPTP-induced neurotoxicity in mice: a role of the gut-microbiota-brain axis.Psychopharmacology, , Volume: 240, Issue:5, 2023
Meclofenoxate Inhibits Aggregation of Alpha-synuclein Protein and peptide letters, , Volume: 30, Issue:5, 2023
Unravelling the destabilization potential of ellagic acid on α-synuclein fibrils using molecular dynamics simulations.Physical chemistry chemical physics : PCCP, , Mar-15, Volume: 25, Issue:11, 2023
Cryo-EM structure of amyloid fibril formed by α-synuclein hereditary A53E mutation reveals a distinct protofilament interface.The Journal of biological chemistry, , Volume: 299, Issue:4, 2023
Pathological Pathways and Alpha-Synuclein in Parkinson's Disease: A View from the Periphery.Frontiers in bioscience (Landmark edition), , 02-23, Volume: 28, Issue:2, 2023
Opposing effects of β-2 and β-1 adrenergic receptor signaling on neuroinflammation and dopaminergic neuron survival in α-synuclein-mediated neurotoxicity.Journal of neuroinflammation, , Mar-02, Volume: 20, Issue:1, 2023
Ginkgolide A improves the pleiotropic function and reinforces the neuroprotective effects by mesenchymal stem cell-derived exosomes in 6-OHDA-induced cell model of Parkinson's disease.Aging, , 02-20, Volume: 15, Issue:5, 2023
Serotonin in synucleinopathies.Behavioural brain research, , 05-08, Volume: 445, 2023
Alpha-synuclein in Parkinson's disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction.Cell death & disease, , 03-01, Volume: 14, Issue:3, 2023
CRISPR-Cas9-Edited SNCA Knockout Human Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons and Their Vulnerability to Neurotoxicity.Biological & pharmaceutical bulletin, , Volume: 46, Issue:3, 2023
Restoration of Adult Neurogenesis by Intranasal Administration of Gangliosides GD3 and GM1 in The Olfactory Bulb of A53T Alpha-Synuclein-Expressing Parkinson's-Disease Model Mice.Molecular neurobiology, , Volume: 60, Issue:6, 2023
Duodenal alpha-Synuclein Pathology and Enteric Gliosis in Advanced Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:5, 2023
Specific Detection of Physiological S129 Phosphorylated α-Synuclein in Tissue Using Proximity Ligation Assay.Journal of Parkinson's disease, , Volume: 13, Issue:2, 2023
Circular RNAs in Parkinson's Disease: Reliable Biological Markers and Targets for Rehabilitation.Molecular neurobiology, , Volume: 60, Issue:6, 2023
Nicotine-Mediated Recruitment of GABAergic Neurons to a Dopaminergic Phenotype Attenuates Motor Deficits in an Alpha-Synuclein Parkinson's Model.International journal of molecular sciences, , Feb-20, Volume: 24, Issue:4, 2023
Role of Deubiquitinases in Parkinson's Disease-Therapeutic Perspectives.Cells, , 02-17, Volume: 12, Issue:4, 2023
Interneuronal In Vivo Transfer of Synaptic Proteins.Cells, , 02-10, Volume: 12, Issue:4, 2023
Mechanisms of Glucocerebrosidase Dysfunction in Parkinson's Disease.Journal of molecular biology, , 06-15, Volume: 435, Issue:12, 2023
Isocyanate induces cytotoxicity via activation of phosphorylated alpha synuclein protein, nitrosative stress, and apoptotic pathway in Parkinson's Disease model-SHSY-5Y cells.Neurological research, , Volume: 45, Issue:7, 2023
Nanoscale imaging of individual amyloid aggregates extracted from brains of Alzheimer and Parkinson patients reveals presence of lipids in α-synuclein but not in amyloid βProtein science : a publication of the Protein Society, , Volume: 32, Issue:4, 2023
DJ-1 Molecular Chaperone Activity Depresses Tau Aggregation Propensity through Interaction with Monomers.Biochemistry, , 03-07, Volume: 62, Issue:5, 2023
Influence of Cholesterol on the Membrane Binding and Conformation of α-Synuclein.The journal of physical chemistry. B, , 03-09, Volume: 127, Issue:9, 2023
Structural and dynamic insights into α-synuclein dimer conformations.Structure (London, England : 1993), , 04-06, Volume: 31, Issue:4, 2023
Integrin Mac1 mediates paraquat and maneb-induced learning and memory impairments in mice through NADPH oxidase-NLRP3 inflammasome axis-dependent microglial activation.Journal of neuroinflammation, , Feb-18, Volume: 20, Issue:1, 2023
Role of rodent models in advancing precision medicine for Parkinson's disease.Handbook of clinical neurology, , Volume: 193, 2023
Spontaneous nucleation and fast aggregate-dependent proliferation of α-synuclein aggregates within liquid condensates at neutral pH.Proceedings of the National Academy of Sciences of the United States of America, , 02-28, Volume: 120, Issue:9, 2023
Selecting the Best Animal Model of Parkinson's Disease for Your Research Purpose: Insight from Current neuropharmacology, , Volume: 21, Issue:5, 2023
Mixed pathology as a rule, not exception: Time to reconsider disease nosology.Handbook of clinical neurology, , Volume: 192, 2023
Models of precision medicine for neurodegeneration.Handbook of clinical neurology, , Volume: 192, 2023
The alteration of intestinal mucosal α-synuclein expression and mucosal microbiota in Parkinson's disease.Applied microbiology and biotechnology, , Volume: 107, Issue:5-6, 2023
Quantitative Seed Amplification Assay: A Proof-of-Principle Study.The journal of physical chemistry. B, , 03-02, Volume: 127, Issue:8, 2023
Protective mechanisms by glial cell line-derived neurotrophic factor and cerebral dopamine neurotrophic factor against the α-synuclein accumulation in Parkinson's disease.Biochemical Society transactions, , 02-27, Volume: 51, Issue:1, 2023
α-Synuclein Conformational Strains as Drivers of Phenotypic Heterogeneity in Neurodegenerative Diseases.Journal of molecular biology, , 06-15, Volume: 435, Issue:12, 2023
TNFRSF10B is involved in motor dysfunction in Parkinson's disease by regulating exosomal α-synuclein secretion from microglia.Journal of chemical neuroanatomy, , Volume: 129, 2023
A functional role for alpha-synuclein in neuroimmune responses.Journal of neuroimmunology, , 03-15, Volume: 376, 2023
The link between neuroinflammation and the neurovascular unit in synucleinopathies.Science advances, , 02-15, Volume: 9, Issue:7, 2023
α-Synuclein induces prodromal symptoms of Parkinson's disease via activating TLR2/MyD88/NF-κB pathway in Schwann cells of vagus nerve in a rat model.Journal of neuroinflammation, , Feb-14, Volume: 20, Issue:1, 2023
Impaired Autophagic-Lysosomal Fusion in Parkinson's Patient Midbrain Neurons Occurs through Loss of ykt6 and Is Rescued by Farnesyltransferase Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 04-05, Volume: 43, Issue:14, 2023
α-Synuclein Aggregation Inhibitory Procerolides and Diphenylalkanes from the Ascidian Journal of natural products, , 03-24, Volume: 86, Issue:3, 2023
Palmitoylation of the Parkinson's disease-associated protein synaptotagmin-11 links its turnover to α-synuclein homeostasis.Science signaling, , 02-14, Volume: 16, Issue:772, 2023
α-Synuclein decoy peptide protects mice against α-synuclein-induced memory loss.CNS neuroscience & therapeutics, , Volume: 29, Issue:6, 2023
Accurate Detection of α-Synuclein Seeds in Cerebrospinal Fluid from Isolated Rapid Eye Movement Sleep Behavior Disorder and Patients with Parkinson's Disease in the DeNovo Parkinson (DeNoPa) Cohort.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:4, 2023
Combined chronic copper exposure and aging lead to neurotoxicity in vivo.Neurotoxicology, , Volume: 95, 2023
Oleuropein confers neuroprotection against rotenone-induced model of Parkinson's disease via BDNF/CREB/Akt pathway.Scientific reports, , 02-11, Volume: 13, Issue:1, 2023
The Parkinson-Associated Toxin Paraquat Shifts Physiological α-Synuclein Tetramers toward Monomers That Can Be Calpain-Truncated and Form Oligomers.The American journal of pathology, , Volume: 193, Issue:5, 2023
DNA Methylation of α-Synuclein Intron 1 Is Significantly Decreased in the Frontal Cortex of Parkinson's Individuals with International journal of molecular sciences, , Jan-31, Volume: 24, Issue:3, 2023
Nuclear α-Synuclein-Derived Cytotoxic Effect via Altered Ribosomal RNA Processing in Primary Mouse Embryonic Fibroblasts.International journal of molecular sciences, , Jan-21, Volume: 24, Issue:3, 2023
Increased Levels of the Parkinson's Disease-Associated Gene ITPKB Correlate with Higher Expression Levels of α-Synuclein, Independent of Mutation Status.International journal of molecular sciences, , Jan-19, Volume: 24, Issue:3, 2023
Dysregulation of astrocytic CaActa neuropathologica, , Volume: 145, Issue:5, 2023
Single-Molecule Two-Color Coincidence Detection of Unlabeled alpha-Synuclein Aggregates.Angewandte Chemie (International ed. in English), , 04-03, Volume: 62, Issue:15, 2023
Translational molecular imaging and drug development in Parkinson's disease.Molecular neurodegeneration, , 02-10, Volume: 18, Issue:1, 2023
Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils.Proceedings of the National Academy of Sciences of the United States of America, , 02-14, Volume: 120, Issue:7, 2023
NLRP3 Inflammasome-Mediated Neuroinflammation and Related Mitochondrial Impairment in Parkinson's Disease.Neuroscience bulletin, , Volume: 39, Issue:5, 2023
Calcium/calmodulin-dependent serine protein kinase exacerbates mitochondrial calcium uniporter-related mitochondrial calcium overload by phosphorylating α-synuclein in Parkinson's disease.The international journal of biochemistry & cell biology, , Volume: 157, 2023
Acid ceramidase involved in pathogenic cascade leading to accumulation of α-synuclein in iPSC model of GBA1-associated Parkinson's disease.Human molecular genetics, , 05-18, Volume: 32, Issue:11, 2023
The couple of netrin-1/α-Synuclein regulates the survival of dopaminergic neurons via α-Synuclein disaggregation.BMB reports, , Volume: 56, Issue:2, 2023
Dermal Real-Time Quaking-Induced Conversion Is a Sensitive Marker to Confirm Isolated Rapid Eye Movement Sleep Behavior Disorder as an Early α-Synucleinopathy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:6, 2023
Skin α-synuclein differentiates synucleinopathies.Nature reviews. Neurology, , Volume: 19, Issue:3, 2023
[no title available]ACS chemical neuroscience, , 03-01, Volume: 14, Issue:5, 2023
Amyloid Fibers of α-Synuclein Catalyze Chemical Reactions.ACS chemical neuroscience, , 02-15, Volume: 14, Issue:4, 2023
High-affinity binding of celastrol to monomeric α-synuclein mitigates in vitro aggregation.Journal of biomolecular structure & dynamics, , Volume: 41, Issue:22, 2023
miR-101a-3p Impairs Synaptic Plasticity and Contributes to Synucleinopathy.Journal of Parkinson's disease, , Volume: 13, Issue:2, 2023
ASC specks exacerbate α‑synuclein pathology via amplifying NLRP3 inflammasome activities.Journal of neuroinflammation, , Feb-05, Volume: 20, Issue:1, 2023
The Ubiquitin Proteasome System as a Therapeutic Area in Parkinson's Disease.Neuromolecular medicine, , Volume: 25, Issue:3, 2023
Linking Genetic Risks to Pathological α-Synuclein Transmission in Parkinson's Disease.Neuroscience bulletin, , Volume: 39, Issue:7, 2023
Common Mechanisms Underlying α-Synuclein-Induced Mitochondrial Dysfunction in Parkinson's Disease.Journal of molecular biology, , 06-15, Volume: 435, Issue:12, 2023
a-Synuclein and lipids in erythrocytes of Gaucher disease carriers and patients before and after enzyme replacement therapy.PloS one, , Volume: 18, Issue:2, 2023
Comprehensive Review on Potential Signaling Pathways Involving the Transfer of α-Synuclein from the Gut to the Brain That Leads to Parkinson's Disease.ACS chemical neuroscience, , 02-15, Volume: 14, Issue:4, 2023
SH-SY5Y Cell Line Journal of integrative neuroscience, , Jan-16, Volume: 22, Issue:1, 2023
Neuron-Derived Misfolded α-Synuclein in Blood: A Potential Biomarker for Parkinson's Disease?Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:3, 2023
SARS-COV-2 infection and Parkinson's disease: Possible links and perspectives.Journal of neuroscience research, , Volume: 101, Issue:6, 2023
A Mouse Model to Test Novel Therapeutics for Parkinson's Disease: an Update on the Thy1-aSyn ("line 61") Mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 20, Issue:1, 2023
Polymorphic Alpha-Synuclein Oligomers: Characterization and Differential Detection with Novel Corresponding Antibodies.Molecular neurobiology, , Volume: 60, Issue:5, 2023
Unveiling new secrets in Parkinson's disease: The glycatome.Behavioural brain research, , 03-28, Volume: 442, 2023
Overexpression of alpha synuclein disrupts APP and Endolysosomal axonal trafficking in a mouse model of synucleinopathy.Neurobiology of disease, , Volume: 178, 2023
Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein.Nature neuroscience, , Volume: 26, Issue:2, 2023
α-Synuclein Induced the Occurrence of RBD via Interaction with OX1R and Modulated Its Degradation.Neuromolecular medicine, , Volume: 25, Issue:2, 2023
A review of the current research on in vivo and in vitro detection for alpha-synuclein: a biomarker of Parkinson's disease.Analytical and bioanalytical chemistry, , Volume: 415, Issue:9, 2023
Hybrids of polyphenolic/quinone acids, the potential preventive and therapeutic drugs for PD: Disaggregate α-Syn fibrils, inhibit inclusions, and repair damaged neurons in mice.European journal of medicinal chemistry, , Mar-05, Volume: 249, 2023
Myrcene Salvages Rotenone-Induced Loss of Dopaminergic Neurons by Inhibiting Oxidative Stress, Inflammation, Apoptosis, and Autophagy.Molecules (Basel, Switzerland), , Jan-10, Volume: 28, Issue:2, 2023
ATP13A2 Gene Silencing in Drosophila Affects Autophagic Degradation of A53T Mutant α-Synuclein.International journal of molecular sciences, , Jan-16, Volume: 24, Issue:2, 2023
Age-Related Changes of the Synucleins Profile in the Mouse Retina.Biomolecules, , 01-15, Volume: 13, Issue:1, 2023
α-Synuclein-Induced Destabilized BMAL1 mRNA Leads to Circadian Rhythm Disruption in Parkinson's Disease.Neurotoxicity research, , Volume: 41, Issue:2, 2023
On the Track of α-Synuclein in the Body: Skin Biopsies for Diagnosing Synucleinopathies?Neurology, , 04-11, Volume: 100, Issue:15, 2023
Effects of the Polyphenols Delphinidin and Rosmarinic Acid on the Inducible Intra-cellular Aggregation of Alpha-Synuclein in Model Neuron Cells.Applied biochemistry and biotechnology, , Volume: 195, Issue:7, 2023
Seed amplification assay for the detection of pathologic alpha-synuclein aggregates in cerebrospinal fluid.Nature protocols, , Volume: 18, Issue:4, 2023
The c-Abl inhibitor IkT-148009 suppresses neurodegeneration in mouse models of heritable and sporadic Parkinson's disease.Science translational medicine, , 01-18, Volume: 15, Issue:679, 2023
Who Ever Said It Would Be Easy? Reflecting on Two Clinical Trials Targeting α-Synuclein.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:3, 2023
Domain and cell type-specific immunolocalisation of voltage-gated potassium channels in the mouse striatum.Journal of chemical neuroanatomy, , Volume: 128, 2023
Mendelian Randomization Analysis Reveals No Causal Relationship Between Plasma α-Synuclein and Parkinson's Disease.Molecular neurobiology, , Volume: 60, Issue:4, 2023
Neuronopathic GBA1L444P Mutation Accelerates Glucosylsphingosine Levels and Formation of Hippocampal Alpha-Synuclein Inclusions.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 01-18, Volume: 43, Issue:3, 2023
Interaction Between the Glymphatic System and α-Synuclein in Parkinson's Disease.Molecular neurobiology, , Volume: 60, Issue:4, 2023
Potential Therapeutic Effects of Policosanol from Insect Wax on Caenorhabditis elegans Models of Parkinson's Disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 18, Issue:1-2, 2023
Unravelling the genetic links between Parkinson's disease and lung cancer.Biological chemistry, , 05-25, Volume: 404, Issue:6, 2023
Lifelong constipation in Parkinson's disease and other clinically defined alpha-synucleinopathies: A population-based study in Southeast Minnesota.Parkinsonism & related disorders, , Volume: 107, 2023
Distinct effects of SDC3 and FGFRL1 on selective neurodegeneration in AD and PD.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 37, Issue:2, 2023
Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson's disease treatment.Acta pharmacologica Sinica, , Volume: 44, Issue:6, 2023
Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers.eLife, , 01-10, Volume: 12, 2023
The effects of KTKEGV repeat motif and intervening ATVA sequence on α-synuclein solubility and assembly.Journal of neurochemistry, , Volume: 165, Issue:2, 2023
EGCG attenuates α-synuclein protofibril-membrane interactions and disrupts the protofibril.International journal of biological macromolecules, , Mar-01, Volume: 230, 2023
Extracellular transportation of α-synuclein by HLA class II molecules.Biochemical and biophysical research communications, , 02-12, Volume: 644, 2023
The Consequences of GBA Deficiency in the Autophagy-Lysosome System in Parkinson's Disease Associated with GBA.Cells, , 01-03, Volume: 12, Issue:1, 2023
Ubiquilin-2 regulates pathological alpha-synuclein.Scientific reports, , 01-06, Volume: 13, Issue:1, 2023
Intrastriatal injection of Parkinson's disease intestine and vagus lysates initiates α-synucleinopathy in rat brain.Cell death & disease, , 01-05, Volume: 14, Issue:1, 2023
Role of α-synuclein in microglia: autophagy and phagocytosis balance neuroinflammation in Parkinson's disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.], , Volume: 72, Issue:3, 2023
α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 02-08, Volume: 43, Issue:6, 2023
The effect of diphenylethane side-chain substituents on dibenzocyclohexadiene formation and their inhibition of α-synuclein aggregation in vitro.Bioorganic & medicinal chemistry, , 01-15, Volume: 78, 2023
On the effect of methionine oxidation on the interplay between α-synuclein and synaptic-like vesicles.International journal of biological macromolecules, , Feb-28, Volume: 229, 2023
Cannabidivarin alleviates α-synuclein aggregation via DAF-16 in Caenorhabditis elegans.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 37, Issue:2, 2023
Relevance of Biochemical Deep Phenotyping for a Personalised Approach to Parkinson's Disease.Neuroscience, , 02-10, Volume: 511, 2023
Aggregated alpha-synuclein transcriptionally activates pro-inflammatory canonical and non-canonical NF-κB signaling pathways in peripheral monocytic cells.Molecular immunology, , Volume: 154, 2023
Evaluation of an Adoptive Cellular Therapy-Based Vaccine in a Transgenic Mouse Model of α-synucleinopathy.ACS chemical neuroscience, , 01-18, Volume: 14, Issue:2, 2023
Intranasal Rotenone Induces Alpha-Synuclein Accumulation, Neuroinflammation and Dopaminergic Neurodegeneration in Middle-Aged Mice.Neurochemical research, , Volume: 48, Issue:5, 2023
α-Synuclein in synaptic function and dysfunction.Trends in neurosciences, , Volume: 46, Issue:2, 2023
The Hidden Cell-to-Cell Trail of α-Synuclein Aggregates.Journal of molecular biology, , 06-15, Volume: 435, Issue:12, 2023
Biomimetically Engineered Amyloid-Shelled Gold Nanocomplexes for Discovering α-Synuclein Oligomer-Degrading Drugs.ACS applied materials & interfaces, , Jan-18, Volume: 15, Issue:2, 2023
Neuroprotective Role of Quercetin against Alpha-Synuclein-Associated Hallmarks in Parkinson's Disease.Current neuropharmacology, , Volume: 21, Issue:7, 2023
Helicobacter hepaticus augmentation triggers Dopaminergic degeneration and motor disorders in mice with Parkinson's disease.Molecular psychiatry, , Volume: 28, Issue:3, 2023
Neuroinflammation, immune response and α-synuclein pathology: how animal models are helping us to connect dots.Expert opinion on drug discovery, , Volume: 18, Issue:1, 2023
Anti-α-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson's disease.Neurobiology of disease, , Volume: 177, 2023
Mitochondrial signaling on innate immunity activation in Parkinson disease.Current opinion in neurobiology, , Volume: 78, 2023
Monitoring α-synuclein aggregation.Neurobiology of disease, , Volume: 176, 2023
Hypoxic stress accelerates the propagation of pathological alpha-synuclein and degeneration of dopaminergic neurons.CNS neuroscience & therapeutics, , Volume: 29, Issue:2, 2023
Conformational change of α-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease.Structure (London, England : 1993), , 01-05, Volume: 31, Issue:1, 2023
Overexpression-Induced α-Synuclein Brain Spreading.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 20, Issue:1, 2023
miRNA in Parkinson's disease: From pathogenesis to theranostic approaches.Journal of cellular physiology, , Volume: 238, Issue:2, 2023
Ganglioside GM3 stimulates lipid-protein co-assembly in α-synuclein amyloid formation.Biophysical chemistry, , Volume: 293, 2023
Proteostasis in Parkinson's disease: Recent development and possible implication in diagnosis and therapeutics.Ageing research reviews, , Volume: 84, 2023
Oligomeric α-synuclein and tau aggregates in NDEVs differentiate Parkinson's disease from atypical parkinsonisms.Neurobiology of disease, , Volume: 176, 2023
Endoplasmic Reticulum Stress-Regulated Chaperones as a Serum Biomarker Panel for Parkinson's Disease.Molecular neurobiology, , Volume: 60, Issue:3, 2023
Pathological α-synuclein accumulation, CSF metabolites changes and brain microstructures in cynomolgus monkeys treated with 6-hydroxydopamine.Neurotoxicology, , Volume: 94, 2023
Brain and Cerebrospinal Fluid α-Synuclein Real-Time Quaking-Induced Conversion Identifies Lewy Body Pathology in LRRK2-PD.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:2, 2023
Hydroxytyrosol and dopamine metabolites: Anti-aggregative effect and neuroprotective activity against α-synuclein-induced toxicity.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, , Volume: 171, 2023
Non-SUMOylated alternative spliced isoforms of alpha-synuclein are more aggregation-prone and toxic.Mechanisms of ageing and development, , Volume: 209, 2023
Repositioning doxycycline for treating synucleinopathies: Evidence from a pre-clinical mouse model.Parkinsonism & related disorders, , Volume: 106, 2023
Review on the interactions between dopamine metabolites and α-Synuclein in causing Parkinson's disease.Neurochemistry international, , Volume: 162, 2023
Role of enteric glia and microbiota-gut-brain axis in parkinson disease pathogenesis.Ageing research reviews, , Volume: 84, 2023
Are patients with Parkinson's disease at a lower risk of catching the common cold? Propensity score matching.Parkinsonism & related disorders, , Volume: 106, 2023
HtrA2 regulates α-Synuclein-mediated mitochondrial reactive oxygen species production in the mitochondria of microglia.Biochemical and biophysical research communications, , 01-01, Volume: 638, 2023
N-homocysteinylation of α-synuclein promotes its aggregation and neurotoxicity.Aging cell, , Volume: 22, Issue:3, 2023
An Update on Peripheral Blood Extracellular Vesicles as Biomarkers for Parkinson's Disease Diagnosis.Neuroscience, , 02-10, Volume: 511, 2023
α-Synuclein aggregation causes muscle atrophy through neuromuscular junction degeneration.Journal of cachexia, sarcopenia and muscle, , Volume: 14, Issue:1, 2023
Nicotine-Mediated Rescue of α-Synuclein Toxicity Requires Synaptic Vesicle Glycoprotein 2 in Drosophila.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:2, 2023
Potential application of heat shock proteins as therapeutic targets in Parkinson's disease.Neurochemistry international, , Volume: 162, 2023
Neuroprotective potential of plant derived parenchymal stem cells extract on environmental and genetic models of Parkinson disease through attenuation of oxidative stress and neuroinflammation.Metabolic brain disease, , Volume: 38, Issue:2, 2023
Endothelial LRP1-ICD Accelerates Cognition-Associated Alpha-Synuclein Pathology and Neurodegeneration through PARP1 Activation in a Mouse Model of Parkinson's Disease.Molecular neurobiology, , Volume: 60, Issue:2, 2023
A Combined Panel of Salivary Biomarkers in de novo Parkinson's Disease.Annals of neurology, , Volume: 93, Issue:3, 2023
Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates.Molecular pharmaceutics, , 01-02, Volume: 20, Issue:1, 2023
Targeting α-synuclein post-translational modifications in Parkinson's disease.Behavioural brain research, , 02-15, Volume: 439, 2023
GALC variants affect galactosylceramidase enzymatic activity and risk of Parkinson's disease.Brain : a journal of neurology, , 05-02, Volume: 146, Issue:5, 2023
Association Between Decreased Srpk3 Expression and Increased Substantia Nigra Alpha-Synuclein Level in an MPTP-Induced Parkinson's Disease Mouse Model.Molecular neurobiology, , Volume: 60, Issue:2, 2023
Differential interactions of α-synuclein conformers affect refolding and activity of proteins.Journal of biochemistry, , Feb-03, Volume: 173, Issue:2, 2023
Microglia and astrocyte activation is region-dependent in the α-synuclein mouse model of Parkinson's disease.Glia, , Volume: 71, Issue:3, 2023
α-Synuclein as a Target for Metallo-Anti-Neurodegenerative Agents.Angewandte Chemie (International ed. in English), , 01-02, Volume: 62, Issue:1, 2023
α-Synuclein induces Th17 differentiation and impairs the function and stability of Tregs by promoting RORC transcription in Parkinson's disease.Brain, behavior, and immunity, , Volume: 108, 2023
Novel naturally occurring autoantibodies attenuate α-synuclein pathology in a mouse model of Parkinson's disease.Neuropathology and applied neurobiology, , Volume: 49, Issue:1, 2023
CHCHD2 p.Thr61Ile knock-in mice exhibit motor defects and neuropathological features of Parkinson's disease.Brain pathology (Zurich, Switzerland), , Volume: 33, Issue:3, 2023
Selective neurodegeneration generated by intravenous α-synuclein pre-formed fibril administration is not associated with endogenous α-synuclein levels in the rat brain.Brain pathology (Zurich, Switzerland), , Volume: 33, Issue:3, 2023
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein.Molecular psychiatry, , Volume: 28, Issue:7, 2023
Decreased Water Mobility Contributes To Increased α-Synuclein Aggregation.Angewandte Chemie (International ed. in English), , 02-06, Volume: 62, Issue:7, 2023
Propagation of Distinct α-Synuclein Strains Within Human Reconstructed Neuronal Network and Associated Neuronal Dysfunctions.Methods in molecular biology (Clifton, N.J.), , Volume: 2551, 2023
α-Synuclein Fibril, Ribbon and Fibril-91 Amyloid Polymorphs Generation for Structural Studies.Methods in molecular biology (Clifton, N.J.), , Volume: 2551, 2023
PET imaging in animal models of Parkinson's disease.Behavioural brain research, , 02-13, Volume: 438, 2023
Salivary α-Synuclein RT-QuIC Correlates with Disease Severity in de novo Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 38, Issue:1, 2023
Low Glucocerebrosidase Activity Predicts Dementia in Parkinson Disease: Less Is Not More!Neurology, , Jan-24, Volume: 100, Issue:4, 2023
Association of Glial Activation and α-Synuclein Pathology in Parkinson's Disease.Neuroscience bulletin, , Volume: 39, Issue:3, 2023
Engineered graphene quantum dot nanocomposite triggers α-synuclein defibrillation: Therapeutics against Parkinson's disease.Nanomedicine : nanotechnology, biology, and medicine, , Volume: 47, 2023
Longitudinal striatal dopamine transporter binding and cerebrospinal fluid alpha-synuclein, amyloid beta, total tau, and phosphorylated tau in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 44, Issue:2, 2023
Olfactory Neuron Prokineticin-2 as a Potential Target in Parkinson's Disease.Annals of neurology, , Volume: 93, Issue:1, 2023
Phytoconstituents of Datura metel extract improved motor coordination in haloperidol-induced cataleptic mice: Dual-target molecular docking and behavioural studies.Journal of ethnopharmacology, , Jan-10, Volume: 300, 2023
The GBA variant E326K is associated with alpha-synuclein aggregation and lipid droplet accumulation in human cell lines.Human molecular genetics, , 02-19, Volume: 32, Issue:5, 2023
Effects of N-terminal Acetylation on the Aggregation of Disease-related α-synuclein Variants.Journal of molecular biology, , 01-15, Volume: 435, Issue:1, 2023
Pathological and Therapeutic Advances in Parkinson's Disease: Mitochondria in the Interplay.Journal of Alzheimer's disease : JAD, , Volume: 94, Issue:s1, 2023
Lysosomal Pathogenesis of Parkinson's Disease: Insights From LRRK2 and GBA1 Rodent Models.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 20, Issue:1, 2023
Nanostructured label-free electrochemical immunosensor for detection of a Parkinson's disease biomarker.Talanta, , Jan-15, Volume: 252, 2023
Failure of diet-induced transcriptional adaptations in alpha-synuclein transgenic mice.Human molecular genetics, , 01-13, Volume: 32, Issue:3, 2023
Spreading of alpha-synuclein between different cell types.Behavioural brain research, , 01-05, Volume: 436, 2023
Parkinson's Disease: A Multisystem Disorder.Neuroscience bulletin, , Volume: 39, Issue:1, 2023
Synthesis of a natural quinoline alkaloid isolated from the deep-sea-derived fungus and its potential as a therapeutic for Parkinson's disease.Journal of Asian natural products research, , Volume: 25, Issue:5, 2023
CSF-derived extracellular vesicles from patients with Parkinson's disease induce symptoms and pathology.Brain : a journal of neurology, , 01-05, Volume: 146, Issue:1, 2023
The Parkinson's disease variant rs356182 regulates neuronal differentiation independently from alpha-synuclein.Human molecular genetics, , 01-01, Volume: 32, Issue:1, 2023
Extracellular vesicle biomarkers for cognitive impairment in Parkinson's disease.Brain : a journal of neurology, , 01-05, Volume: 146, Issue:1, 2023
Functional and Pathological Effects of α-Synuclein on Synaptic SNARE Complexes.Journal of molecular biology, , 01-15, Volume: 435, Issue:1, 2023
Liquid-liquid Phase Separation of α-Synuclein: A New Mechanistic Insight for α-Synuclein Aggregation Associated with Parkinson's Disease Pathogenesis.Journal of molecular biology, , 01-15, Volume: 435, Issue:1, 2023
Structural Insights of FeJournal of molecular biology, , 01-15, Volume: 435, Issue:1, 2023
Curcumin-loaded human endometrial stem cells derived exosomes as an effective carrier to suppress alpha-synuclein aggregates in 6OHDA-induced Parkinson's disease mouse model.Cell and tissue banking, , Volume: 24, Issue:1, 2023
Phosphorylated α-synuclein in skin Schwann cells: a new biomarker for multiple system atrophy.Brain : a journal of neurology, , 03-01, Volume: 146, Issue:3, 2023
α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 101, 2022
Dopaminergic Positron Emission Tomography Imaging in the Alpha-Synuclein Preformed Fibril Model Reveals Similarities to Early Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:8, 2022
Evidence for immune system alterations in peripheral biological fluids in Parkinson's disease.Neurobiology of disease, , Volume: 170, 2022
Vocal changes in a zebra finch model of Parkinson's disease characterized by alpha-synuclein overexpression in the song-dedicated anterior forebrain pathway.PloS one, , Volume: 17, Issue:5, 2022
Raman Spectroscopy Study of Skin Biopsies from Patients with Parkinson's Disease: Trends in Alpha-Synuclein Aggregation from the Amide I Region.Applied spectroscopy, , Volume: 76, Issue:11, 2022
Exploring the Role of Ubiquitin-Proteasome System in Parkinson's Disease.Molecular neurobiology, , Volume: 59, Issue:7, 2022
Evolution of α-synuclein conformation ensemble toward amyloid fibril via liquid-liquid phase separation (LLPS) as investigated by dynamic nuclear polarization-enhanced solid-state MAS NMR.Neurochemistry international, , Volume: 157, 2022
Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial.EBioMedicine, , Volume: 80, 2022
Disease-Modifying Therapies for Multiple System Atrophy: Where Are We in 2022?Journal of Parkinson's disease, , Volume: 12, Issue:5, 2022
A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity.Science advances, , 04-29, Volume: 8, Issue:17, 2022
α-Synuclein phase separation and amyloid aggregation are modulated by C-terminal truncations.FEBS letters, , Volume: 596, Issue:11, 2022
Elevated α-synuclein and NfL levels in tear fluids and decreased retinal microvascular densities in patients with Parkinson's disease.GeroScience, , Volume: 44, Issue:3, 2022
Misfolded GBA/β-glucocerebrosidase impairs ER-quality control by chaperone-mediated autophagy in Parkinson disease.Autophagy, , Volume: 18, Issue:12, 2022
Foldamers reveal and validate therapeutic targets associated with toxic α-synuclein self-assembly.Nature communications, , 04-27, Volume: 13, Issue:1, 2022
Design, Synthesis, and Biological Evaluation of Potent 20S Proteasome Activators for the Potential Treatment of α-Synucleinopathies.Journal of medicinal chemistry, , 05-12, Volume: 65, Issue:9, 2022
Mechanisms of enhanced aggregation and fibril formation of Parkinson's disease-related variants of α-synuclein.Scientific reports, , 04-26, Volume: 12, Issue:1, 2022
Reduction of the α-synuclein expression promotes slowing down early neuropathology development in the Journal of neurogenetics, , Volume: 36, Issue:1, 2022
7,8-Dihydroxyflavone ameliorates mitochondrial impairment and motor dysfunction in the α-synuclein 1-103 transgenic mice.Neurobiology of disease, , Volume: 169, 2022
Binding Stability of Antibody-α-Synuclein Complexes Predicts the Protective Efficacy of Anti-α-synuclein Antibodies.Molecular neurobiology, , Volume: 59, Issue:7, 2022
A Novel NOX Inhibitor Treatment Attenuates Parkinson's Disease-Related Pathology in Mouse Models.International journal of molecular sciences, , Apr-12, Volume: 23, Issue:8, 2022
[no title available]Cells, , 04-08, Volume: 11, Issue:8, 2022
Cell Culture Media, Unlike the Presence of Insulin, Affect α-Synuclein Aggregation in Dopaminergic Neurons.Biomolecules, , 04-09, Volume: 12, Issue:4, 2022
α-Synuclein at the Presynaptic Axon Terminal as a Double-Edged Sword.Biomolecules, , 03-27, Volume: 12, Issue:4, 2022
The understanding of Parkinson's disease through genetics and new therapies.Brain and behavior, , Volume: 12, Issue:5, 2022
GM1 ganglioside modifies microglial and neuroinflammatory responses to α-synuclein in the rat AAV-A53T α-synuclein model of Parkinson's disease.Molecular and cellular neurosciences, , Volume: 120, 2022
Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases.Progress in neurobiology, , Volume: 214, 2022
Alpha-synuclein-mediated DNA damage, STING activation, and neuroinflammation in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 04-26, Volume: 119, Issue:17, 2022
A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 19, Issue:3, 2022
Regional changes of brain structure during progression of idiopathic Parkinson's disease - A longitudinal study using deformation based morphometry.Cortex; a journal devoted to the study of the nervous system and behavior, , Volume: 151, 2022
SNCA-AS1 in aging and Parkinson's disease.Aging, , 04-18, Volume: 14, Issue:8, 2022
Blood-based biomarker in Parkinson's disease: potential for future applications in clinical research and practice.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 129, Issue:9, 2022
REM sleep behavior disorder and cerebrospinal fluid alpha-synuclein, amyloid beta, total tau and phosphorylated tau in Parkinson's disease: a cross-sectional and longitudinal study.Journal of neurology, , Volume: 269, Issue:9, 2022
A Randomized First-in-Human Study With UB-312, a UBITh® α-Synuclein Peptide Vaccine.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:7, 2022
Structural and mechanistic insights into modulation of α-Synuclein fibril formation by aloin and emodin.Biochimica et biophysica acta. General subjects, , Volume: 1866, Issue:7, 2022
The GBA1 D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models.Disease models & mechanisms, , 06-01, Volume: 15, Issue:6, 2022
[Morphochemical study of alpha-synuclein, iron and iron-containing proteins in the substantia nigra of the brain in Parkinson's disease].Arkhiv patologii, , Volume: 84, Issue:2, 2022
Single-Particle Resolution of Copper-Associated Annular α-Synuclein Oligomers Reveals Potential Therapeutic Targets of Neurodegeneration.ACS chemical neuroscience, , 05-04, Volume: 13, Issue:9, 2022
Sesquiterpenoids isolated from davana (Artemisia pallens Wall. ex DC) mitigates parkinsonism in Caenorhabditis elegans disease model.Biochemical and biophysical research communications, , 06-18, Volume: 609, 2022
Understanding the Inhibitory and Antioxidant Effects of Pyrroloquinoline Quinone (PQQ) on Copper(II)-Induced α-Synuclein-119 Aggregation.ACS chemical neuroscience, , 04-20, Volume: 13, Issue:8, 2022
Immune Response Modifications in the Genetic Forms of Parkinson's Disease: What Do We Know?International journal of molecular sciences, , Mar-23, Volume: 23, Issue:7, 2022
Insights into the inhibitory mechanism of skullcapflavone II against α-synuclein aggregation and its mediated cytotoxicity.International journal of biological macromolecules, , Jun-01, Volume: 209, Issue:Pt A, 2022
LncRNA HOTAIR promotes α-synuclein aggregation and apoptosis of SH-SY5Y cells by regulating miR-221-3p in Parkinson's disease.Experimental cell research, , 08-01, Volume: 417, Issue:1, 2022
A53T mutant α-synuclein fibrils formed in macrophage are spread to neurons.Cellular and molecular life sciences : CMLS, , Apr-10, Volume: 79, Issue:5, 2022
Alpha-synucleinopathy reduces NMNAT3 protein levels and neurite formation that can be rescued by targeting the NAD+ pathway.Human molecular genetics, , 08-25, Volume: 31, Issue:17, 2022
α-Synuclein arginylation in the human brain.Translational neurodegeneration, , 04-08, Volume: 11, Issue:1, 2022
Genetic heterogeneity on sleep disorders in Parkinson's disease: a systematic review and meta-analysis.Translational neurodegeneration, , 04-08, Volume: 11, Issue:1, 2022
Poly (ADP-Ribose) and α-synuclein extracellular vesicles in patients with Parkinson disease: A possible biomarker of disease severity.PloS one, , Volume: 17, Issue:4, 2022
Change in the Oligomeric State of α-Synuclein Variants in Living Cells.ACS chemical neuroscience, , 04-20, Volume: 13, Issue:8, 2022
The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains.The Journal of biological chemistry, , Volume: 298, Issue:5, 2022
Rationally designed helical peptidomimetics disrupt α-synuclein fibrillation.Chemical communications (Cambridge, England), , Apr-21, Volume: 58, Issue:33, 2022
Fatty acid balance regulates α-synuclein pathology.Trends in neurosciences, , Volume: 45, Issue:6, 2022
Neuropathology of α-synuclein in Parkinson's disease.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 42, Issue:2, 2022
Sphingolipid changes in Parkinson L444P GBA mutation fibroblasts promote α-synuclein aggregation.Brain : a journal of neurology, , 04-29, Volume: 145, Issue:3, 2022
O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies.ACS chemical neuroscience, , 04-20, Volume: 13, Issue:8, 2022
α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity.Proceedings of the National Academy of Sciences of the United States of America, , 04-12, Volume: 119, Issue:15, 2022
Distribution of α-Synuclein Aggregation in the Peripheral Tissues.Neurochemical research, , Volume: 47, Issue:12, 2022
Initiation and progression of α-synuclein pathology in Parkinson's disease.Cellular and molecular life sciences : CMLS, , Mar-26, Volume: 79, Issue:4, 2022
Chicago sky blue 6B inhibits α-synuclein aggregation and propagation.Molecular brain, , 03-28, Volume: 15, Issue:1, 2022
Relationships of Nutritional Factors and Agrochemical Exposure with Parkinson's Disease in the Province of Brescia, Italy.International journal of environmental research and public health, , 03-11, Volume: 19, Issue:6, 2022
SARS-CoV-2 Proteins Interact with Alpha Synuclein and Induce Lewy Body-like Pathology In Vitro.International journal of molecular sciences, , Mar-21, Volume: 23, Issue:6, 2022
The Role of NEDD4 E3 Ubiquitin-Protein Ligases in Parkinson's Disease.Genes, , 03-14, Volume: 13, Issue:3, 2022
Alpha-Synuclein-Specific Naturally Occurring Antibodies Inhibit Aggregation In Vitro and In Vivo.Biomolecules, , 03-18, Volume: 12, Issue:3, 2022
Endogenous Human Proteins Interfering with Amyloid Formation.Biomolecules, , 03-14, Volume: 12, Issue:3, 2022
Leukotriene Signaling as a Target in α-Synucleinopathies.Biomolecules, , 02-23, Volume: 12, Issue:3, 2022
Hydrogen Sulfide Produced by Gut Bacteria May Induce Parkinson's Disease.Cells, , 03-12, Volume: 11, Issue:6, 2022
Acidic nanoparticles protect against α-synuclein-induced neurodegeneration through the restoration of lysosomal function.Aging cell, , Volume: 21, Issue:4, 2022
Nano-MgO composites containing plasmid DNA to silence SNCA gene displays neuroprotective effects in Parkinson's rats induced by 6-hydroxydopamine.European journal of pharmacology, , May-05, Volume: 922, 2022
Paraquat Inhibits Autophagy Via Intensifying the Interaction Between HMGB1 and α-Synuclein.Neurotoxicity research, , Volume: 40, Issue:2, 2022
Sustained chemogenetic activation of locus coeruleus norepinephrine neurons promotes dopaminergic neuron survival in synucleinopathy.PloS one, , Volume: 17, Issue:3, 2022
Immune responses in the Parkinson's disease brain.Neurobiology of disease, , 06-15, Volume: 168, 2022
Celastrol Downmodulates Alpha-Synuclein-Specific T Cell Responses by Mediating Antigen Trafficking in Dendritic Cells.Frontiers in immunology, , Volume: 13, 2022
Synthesis of Evodileptin B, a Natural Anthranilate Derivative Isolated from Evodia lepta, and Evaluation of Its Therapeutic Potential against Parkinson's Disease.Chemistry & biodiversity, , Volume: 19, Issue:5, 2022
Immunotherapeutic interventions in Parkinson's disease: Focus on α-Synuclein.Advances in protein chemistry and structural biology, , Volume: 129, 2022
α-Synuclein binding activity of the plant growth promoter asterubine.Bioorganic & medicinal chemistry letters, , 05-15, Volume: 64, 2022
Synthesis and evaluation of novel radioiodinated phenylbenzofuranone derivatives as α-synuclein imaging probes.Bioorganic & medicinal chemistry letters, , 05-15, Volume: 64, 2022
Parkinson's disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein-induced changes in maturation and immune reactive properties.Proceedings of the National Academy of Sciences of the United States of America, , 03-22, Volume: 119, Issue:12, 2022
CIITA expression is regulated by histone deacetylase enzymes and has a role in α-synuclein pre-formed fibril-induced antigen presentation in murine microglial cell line.Immunopharmacology and immunotoxicology, , Volume: 44, Issue:3, 2022
α-Synuclein Radiotracer Development and In Vivo Imaging: Recent Advancements and New Perspectives.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:5, 2022
Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models.Autophagy, , Volume: 18, Issue:5, 2022
Single Molecule Fingerprinting Reveals Different Amplification Properties of α-Synuclein Oligomers and Preformed Fibrils in Seeding Assay.ACS chemical neuroscience, , 04-06, Volume: 13, Issue:7, 2022
Brain injections of glial cytoplasmic inclusions induce a multiple system atrophy-like pathology.Brain : a journal of neurology, , 04-29, Volume: 145, Issue:3, 2022
The roles of connectivity and neuronal phenotype in determining the pattern of α-synuclein pathology in Parkinson's disease.Neurobiology of disease, , 06-15, Volume: 168, 2022
Comparison of commercially available antibodies for the detection of phosphorylated alpha-synuclein in primary culture of ENS.Neurogastroenterology and motility, , Volume: 34, Issue:6, 2022
Diagnostic Value of Salivary Real-Time Quaking-Induced Conversion in Parkinson's Disease and Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:5, 2022
Cardiac Alpha-Synuclein Is Present in Alpha-Synucleinopathies.Journal of Parkinson's disease, , Volume: 12, Issue:4, 2022
Crocin Protects Malathion-Induced Striatal Biochemical Deficits by Inhibiting Apoptosis and Increasing α-Synuclein in Rats' Striatum.Journal of molecular neuroscience : MN, , Volume: 72, Issue:5, 2022
Synuclein-One study: skin biopsy detection of phosphorylated α-synuclein for diagnosis of synucleinopathies.Biomarkers in medicine, , Volume: 16, Issue:7, 2022
Pathological Relevance of Post-Translationally Modified Alpha-Synuclein (pSer87, pSer129, nTyr39) in Idiopathic Parkinson's Disease and Multiple System Atrophy.Cells, , 03-06, Volume: 11, Issue:5, 2022
LRRK2 Inhibition Mitigates the Neuroinflammation Caused by TLR2-Specific α-Synuclein and Alleviates Neuroinflammation-Derived Dopaminergic Neuronal Loss.Cells, , 03-02, Volume: 11, Issue:5, 2022
Transcellular propagation of fibrillar α-synuclein from enteroendocrine to neuronal cells requires cell-to-cell contact and is Rab35-dependent.Scientific reports, , 03-09, Volume: 12, Issue:1, 2022
Isogenic human SNCA gene dosage induced pluripotent stem cells to model Parkinson's disease.Stem cell research, , Volume: 60, 2022
A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson disease.PLoS biology, , Volume: 20, Issue:3, 2022
Low dose DMSO treatment induces oligomerization and accelerates aggregation of α-synuclein.Scientific reports, , 03-08, Volume: 12, Issue:1, 2022
[Autonomic Dysfunction in Lewy Body Disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 74, Issue:3, 2022
Ferroptosis in Parkinson's disease: glia-neuron crosstalk.Trends in molecular medicine, , Volume: 28, Issue:4, 2022
Pathophysiological significance of increased α-synuclein deposition in sympathetic nerves in Parkinson's disease: a post-mortem observational study.Translational neurodegeneration, , 03-08, Volume: 11, Issue:1, 2022
Long-term hyperglycemia aggravates α-synuclein aggregation and dopaminergic neuronal loss in a Parkinson's disease mouse model.Translational neurodegeneration, , 03-07, Volume: 11, Issue:1, 2022
Gene therapy of yeast NDI1 on mitochondrial complex I dysfunction in rotenone-induced Parkinson's disease models in vitro and vivo.Molecular medicine (Cambridge, Mass.), , 03-07, Volume: 28, Issue:1, 2022
Neuronal Presentation of Antigen and Its Possible Role in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
PTEN-Induced Putative Kinase 1 Dysfunction Accelerates Synucleinopathy.Journal of Parkinson's disease, , Volume: 12, Issue:4, 2022
Striatal synaptic bioenergetic and autophagic decline in premotor experimental parkinsonism.Brain : a journal of neurology, , 06-30, Volume: 145, Issue:6, 2022
Ferulic Acid Exerts Neuroprotective Effects via Autophagy Induction in Oxidative medicine and cellular longevity, , Volume: 2022, 2022
Plasma α-synuclein and phosphorylated tau 181 as a diagnostic biomarker panel for de novo Parkinson's disease.Journal of neurochemistry, , Volume: 161, Issue:6, 2022
Pharmacological Intervention Targeting FAF1 Restores Autophagic Flux for α-Synuclein Degradation in the Brain of a Parkinson's Disease Mouse Model.ACS chemical neuroscience, , 03-16, Volume: 13, Issue:6, 2022
Tailoring a Nanochaperone to Regulate α-Synuclein Assembly.Angewandte Chemie (International ed. in English), , 05-02, Volume: 61, Issue:19, 2022
Ferritinophagy and α-Synuclein: Pharmacological Targeting of Autophagy to Restore Iron Regulation in Parkinson's Disease.International journal of molecular sciences, , Feb-21, Volume: 23, Issue:4, 2022
Sequential or Simultaneous Injection of Preformed Fibrils and AAV Overexpression of Alpha-Synuclein Are Equipotent in Producing Relevant Pathology and Behavioral Deficits.Journal of Parkinson's disease, , Volume: 12, Issue:4, 2022
Slowing Parkinson's Disease Progression with Vaccination and Other Immunotherapies.CNS drugs, , Volume: 36, Issue:4, 2022
Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson's disease.Scientific reports, , 02-24, Volume: 12, Issue:1, 2022
Ischemic stroke causes Parkinson's disease-like pathology and symptoms in transgenic mice overexpressing alpha-synuclein.Acta neuropathologica communications, , 02-24, Volume: 10, Issue:1, 2022
Update on CSF Biomarkers in Parkinson's Disease.Biomolecules, , 02-18, Volume: 12, Issue:2, 2022
How Lazy Reading and Semantic Sloppiness May Harm Progress in Synucleinopathy Research.Biomolecules, , 01-28, Volume: 12, Issue:2, 2022
Unique Lewy pathology in myotonic dystrophy type 1.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 42, Issue:2, 2022
Cytokines, miRNAs, and Antioxidants as Combined Non-invasive Biomarkers for Parkinson's Disease.Journal of molecular neuroscience : MN, , Volume: 72, Issue:5, 2022
Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson's disease.Molecular neurodegeneration, , 02-23, Volume: 17, Issue:1, 2022
Is a cure for Parkinson's disease hiding inside us?Trends in biochemical sciences, , Volume: 47, Issue:8, 2022
α-Synuclein-containing erythrocytic extracellular vesicles: essential contributors to hyperactivation of monocytes in Parkinson's disease.Journal of neuroinflammation, , Feb-22, Volume: 19, Issue:1, 2022
CRISPR-Cas9 Gene Editing Protects from the A53T-SNCA Overexpression-Induced Pathology of Parkinson's Disease The CRISPR journal, , Volume: 5, Issue:1, 2022
Generation of an induced pluripotent stem cell line (EURACi014-A) from a Parkinson's disease patient with an A53T mutation in the SNCA gene by an integration-free reprogramming method.Stem cell research, , Volume: 60, 2022
Glucocerebrosidase-associated Parkinson disease: Pathogenic mechanisms and potential drug treatments.Neurobiology of disease, , Volume: 166, 2022
Lysosomal ceramides regulate cathepsin B-mediated processing of saposin C and glucocerebrosidase activity.Human molecular genetics, , 07-21, Volume: 31, Issue:14, 2022
Discovery of Neuroprotective Agents Based on a 5-(4-Pyridinyl)-1,2,4-triazole Scaffold.ACS chemical neuroscience, , 03-02, Volume: 13, Issue:5, 2022
Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor impairment and cortical dysfunction, independent of protein aggregation.Human molecular genetics, , 10-28, Volume: 31, Issue:21, 2022
Ambroxol reverses tau and α-synuclein accumulation in a cholinergic N370S GBA1 mutation model.Human molecular genetics, , 07-21, Volume: 31, Issue:14, 2022
α-Synuclein in Parkinson's disease and advances in detection.Clinica chimica acta; international journal of clinical chemistry, , Apr-01, Volume: 529, 2022
Gene Co-expression Analysis of the Human Substantia Nigra Identifies ZNHIT1 as an SNCA Co-expressed Gene that Protects Against α-Synuclein-Induced Impairments in Neurite Growth and Mitochondrial Dysfunction in SH-SY5Y Cells.Molecular neurobiology, , Volume: 59, Issue:5, 2022
Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological α-synuclein.Cell reports, , 02-15, Volume: 38, Issue:7, 2022
S-Nitrosylation of p62 Inhibits Autophagic Flux to Promote α-Synuclein Secretion and Spread in Parkinson's Disease and Lewy Body Dementia.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 04-06, Volume: 42, Issue:14, 2022
Current Progress in the Development of Probes for Targeting α-Synuclein Aggregates.ACS chemical neuroscience, , 03-02, Volume: 13, Issue:5, 2022
Predictive Modeling of Neurotoxic α-Synuclein Polymorphs.Methods in molecular biology (Clifton, N.J.), , Volume: 2340, 2022
Astrocytes expressing Vitamin D-activating enzyme identify Parkinson's disease.CNS neuroscience & therapeutics, , Volume: 28, Issue:5, 2022
α-Synuclein-activated microglia are implicated in PD pathogenesis.Nature reviews. Neurology, , Volume: 18, Issue:4, 2022
Interaction of Alpha Synuclein and Microtubule Organization Is Linked to Impaired Neuritic Integrity in Parkinson's Patient-Derived Neuronal Cells.International journal of molecular sciences, , Feb-05, Volume: 23, Issue:3, 2022
Roles of α-Synuclein and Disease-Associated Factors in International journal of molecular sciences, , Jan-28, Volume: 23, Issue:3, 2022
Fat and Protein Combat Triggers Immunological Weapons of Innate and Adaptive Immune Systems to Launch Neuroinflammation in Parkinson's Disease.International journal of molecular sciences, , Jan-19, Volume: 23, Issue:3, 2022
Characterization of molecular biomarkers in cerebrospinal fluid and serum of E46K-SNCA mutation carriers.Parkinsonism & related disorders, , Volume: 96, 2022
In vivo imaging of alpha-synuclein with antibody-based PET.Neuropharmacology, , 05-01, Volume: 208, 2022
The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization.Communications biology, , 02-10, Volume: 5, Issue:1, 2022
Upregulation of α-synuclein following immune activation: Possible trigger of Parkinson's disease.Neurobiology of disease, , Volume: 166, 2022
Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations.Acta neuropathologica, , Volume: 143, Issue:4, 2022
Adenosine A1 receptor ligands bind to α-synuclein: implications for α-synuclein misfolding and α-synucleinopathy in Parkinson's disease.Translational neurodegeneration, , 02-10, Volume: 11, Issue:1, 2022
LncRNA miR-17-92a-1 cluster host gene (MIR17HG) promotes neuronal damage and microglial activation by targeting the microRNA-153-3p/alpha-synuclein axis in Parkinson's disease.Bioengineered, , Volume: 13, Issue:2, 2022
Senescence and impaired DNA damage responses in alpha-synucleinopathy models.Experimental & molecular medicine, , Volume: 54, Issue:2, 2022
Insulin-like growth factor 2 and autophagy gene expression alteration arise as potential biomarkers in Parkinson's disease.Scientific reports, , 02-07, Volume: 12, Issue:1, 2022
Doxorubicin induced aggregation of α-synuclein: Insights into the mechanism of drug induced Parkinsonism.Colloids and surfaces. B, Biointerfaces, , Volume: 212, 2022
Modeling the cellular fate of alpha-synuclein aggregates: A pathway to pathology.Current opinion in neurobiology, , Volume: 72, 2022
Alpha and Beta Synucleins: From Pathophysiology to Clinical Application as Biomarkers.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:4, 2022
Anti-α-synuclein Toxicity and Anti-neurodegenerative Role of Chrysin in Transgenic ACS chemical neuroscience, , 02-16, Volume: 13, Issue:4, 2022
Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy.Proceedings of the National Academy of Sciences of the United States of America, , 02-08, Volume: 119, Issue:6, 2022
Living in α-syn: Tackling aggregates in Parkinson's disease.Neuron, , 02-02, Volume: 110, Issue:3, 2022
Inhibition-mediated changes in prolyl oligopeptidase dynamics possibly related to α-synuclein aggregation.Physical chemistry chemical physics : PCCP, , Feb-16, Volume: 24, Issue:7, 2022
Lysophosphatidylcholine acyltransferase 1 promotes pathology and toxicity in two distinct cell-based alpha-synuclein models.Neuroscience letters, , 02-16, Volume: 772, 2022
Assessment of Glucocerebrosidase Enzyme Activity in Parkinson Disease Using Multiple Approaches.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:3, 2022
Alpha-synuclein negatively controls cell proliferation in dopaminergic neurons.Molecular and cellular neurosciences, , Volume: 119, 2022
Neurodegeneration and neuroinflammation are linked, but independent of alpha-synuclein inclusions, in a seeding/spreading mouse model of Parkinson's disease.Glia, , Volume: 70, Issue:5, 2022
The mitochondrial protein Sideroflexin 3 (SFXN3) influences neurodegeneration pathways in vivo.The FEBS journal, , Volume: 289, Issue:13, 2022
Novel engineered nanobodies specific for N-terminal region of alpha-synuclein recognize Lewy-body pathology and inhibit in-vitro seeded aggregation and toxicity.The FEBS journal, , Volume: 289, Issue:15, 2022
Age-dependent aggregation of α-synuclein in the nervous system of gut-brain axis is associated with caspase-1 activation.Metabolic brain disease, , Volume: 37, Issue:5, 2022
Pathogenic Mechanisms of Cytosolic and Membrane-Enriched α-Synuclein Converge on Fatty Acid Homeostasis.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 03-09, Volume: 42, Issue:10, 2022
Repurposing Pomalidomide as a Neuroprotective Drug: Efficacy in an Alpha-Synuclein-Based Model of Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 19, Issue:1, 2022
Longitudinal Study of SNCA Rep1 Polymorphism on Executive Function in Early Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:3, 2022
Olfactory Bulb Excitotoxicity as a Gap-Filling Mechanism Underlying the Link Between Traumatic Brain Injury-Induced Secondary Neuronal Degeneration and Parkinson's Disease-Like Pathology.Neurochemical research, , Volume: 47, Issue:4, 2022
Impaired Sphingolipid Hydrolase Activities in Dementia with Lewy Bodies and Multiple System Atrophy.Molecular neurobiology, , Volume: 59, Issue:4, 2022
Gaucher disease - more than just a rare lipid storage disease.Journal of molecular medicine (Berlin, Germany), , Volume: 100, Issue:4, 2022
Buffering capacity is determinant for restoring early α-synuclein aggregation.Biophysical chemistry, , Volume: 282, 2022
High-Sensitivity Single Molecule Array Assays for Pathological Isoforms in Parkinson's Disease.Clinical chemistry, , 03-04, Volume: 68, Issue:3, 2022
[Aggregation and spread of synuclein in Parkinson's disease].Medecine sciences : M/S, , Volume: 38, Issue:1, 2022
Non-clinical Pharmacology of YTX-7739: a Clinical Stage Stearoyl-CoA Desaturase Inhibitor Being Developed for Parkinson's Disease.Molecular neurobiology, , Volume: 59, Issue:4, 2022
β-Synuclein: An Enigmatic Protein with Diverse Functionality.Biomolecules, , 01-16, Volume: 12, Issue:1, 2022
Insights into the Interactions that Trigger the Primary Nucleation of Polymorphic α-Synuclein Dimers.ACS chemical neuroscience, , 02-02, Volume: 13, Issue:3, 2022
α-synuclein-assisted oligomerization of β-amyloid (1-42).Archives of biochemistry and biophysics, , 03-15, Volume: 717, 2022
Subthalamic deep brain stimulation in Parkinson's disease with SNCA mutations: Based on the follow-up to 10 years.Brain and behavior, , Volume: 12, Issue:2, 2022
Infectious Agents as Potential Drivers of α-Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:3, 2022
Drosophila: A Model to Study the Pathogenesis of Parkinson's Disease.CNS & neurological disorders drug targets, , Volume: 21, Issue:3, 2022
Synapsin III gene silencing redeems alpha-synuclein transgenic mice from Parkinson's disease-like phenotype.Molecular therapy : the journal of the American Society of Gene Therapy, , 04-06, Volume: 30, Issue:4, 2022
T cells, α-synuclein and Parkinson disease.Handbook of clinical neurology, , Volume: 184, 2022
Alpha-synuclein and cortico-striatal plasticity in animal models of Parkinson disease.Handbook of clinical neurology, , Volume: 184, 2022
Clinical and imaging evidence of brain-first and body-first Parkinson's disease.Neurobiology of disease, , Volume: 164, 2022
Controlled Activation of TRPV1 Channels on Microglia to Boost Their Autophagy for Clearance of Alpha-Synuclein and Enhance Therapy of Parkinson's Disease.Advanced materials (Deerfield Beach, Fla.), , Volume: 34, Issue:11, 2022
A Matrigel-based 3D construct of SH-SY5Y cells models the α-synuclein pathologies of Parkinson's disease.Disease models & mechanisms, , 03-01, Volume: 15, Issue:3, 2022
Chemoselective Bioconjugation of Amyloidogenic Protein Antigens to PEGylated Microspheres Enables Detection of α-Synuclein Autoantibodies in Human Plasma.Bioconjugate chemistry, , 02-16, Volume: 33, Issue:2, 2022
Combining Skin α-Synuclein Real-Time Quaking-Induced Conversion and Circulating Neurofilament Light Chain to Distinguish Multiple System Atrophy and Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:3, 2022
Therapeutics in the Pipeline Targeting Pharmacological reviews, , Volume: 74, Issue:1, 2022
Two-step screening method to identify α-synuclein aggregation inhibitors for Parkinson's disease.Scientific reports, , 01-10, Volume: 12, Issue:1, 2022
Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain.Molecular neurodegeneration, , 01-10, Volume: 17, Issue:1, 2022
Strong Predictive Algorithm of Pathogenesis-Based Biomarkers Improves Parkinson's Disease Diagnosis.Molecular neurobiology, , Volume: 59, Issue:3, 2022
Roflupram attenuates α-synuclein-induced cytotoxicity and promotes the mitochondrial translocation of Parkin in SH-SY5Y cells overexpressing A53T mutant α-synuclein.Toxicology and applied pharmacology, , 02-01, Volume: 436, 2022
Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells.Molecular neurobiology, , Volume: 59, Issue:2, 2022
Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A): Could It Be a Promising Biomarker and Therapeutic Target in Parkinson's Disease?Molecular neurobiology, , Volume: 59, Issue:2, 2022
Phosphorylated α-synuclein in diluted human serum as a biomarker for Parkinson's disease.Biomedical journal, , Volume: 45, Issue:6, 2022
Analysis of circulating metabolites to differentiate Parkinson's disease and essential tremor.Neuroscience letters, , 01-19, Volume: 769, 2022
Genetic modulators associated with regulatory surveillance of mitochondrial quality control, play a key role in regulating stress pathways and longevity in C. elegans.Life sciences, , Feb-01, Volume: 290, 2022
Animal models of brain-first and body-first Parkinson's disease.Neurobiology of disease, , Volume: 163, 2022
Digesting recent findings: gut alpha-synuclein, microbiome changes in Parkinson's disease.Trends in endocrinology and metabolism: TEM, , Volume: 33, Issue:2, 2022
Rapid Induction of Dopaminergic Neuron Loss Accompanied by Lewy Body-Like Inclusions in A53T BAC-SNCA Transgenic Mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 19, Issue:1, 2022
Wilful pathogens provoke a gut feeling in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 129, Issue:5-6, 2022
Intermediates of α-synuclein aggregation: Implications in Parkinson's disease pathogenesis.Biophysical chemistry, , Volume: 281, 2022
Association of plasma α-synuclein with cardiac Neuroscience letters, , 01-23, Volume: 770, 2022
Differentially targeted seeding reveals unique pathological alpha-synuclein propagation patterns.Brain : a journal of neurology, , 06-03, Volume: 145, Issue:5, 2022
Motor and non-motor circuit disturbances in early Parkinson disease: which happens first?Nature reviews. Neuroscience, , Volume: 23, Issue:2, 2022
Bioactive lipids and their metabolism: New therapeutic opportunities for Parkinson's disease.The European journal of neuroscience, , Volume: 55, Issue:3, 2022
Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies.Brain : a journal of neurology, , 04-18, Volume: 145, Issue:2, 2022
Can the lack of fibrillar form of alpha-synuclein in Lewy bodies be explained by its catalytic activity?Mathematical biosciences, , Volume: 344, 2022
Combination of liquid crystal and deep learning reveals distinct signatures of Parkinson's disease-related wild-type α-synuclein and six pathogenic mutants.Chemistry, an Asian journal, , Jan-17, Volume: 17, Issue:2, 2022
Presence of Skin α-Synuclein Deposits Discriminates Parkinson's Disease from Progressive Supranuclear Palsy and Corticobasal Syndrome.Journal of Parkinson's disease, , Volume: 12, Issue:2, 2022
Elevated norepinephrine may interact with alpha-synuclein to promote Parkinson's disease and DLB.Acta neurologica Scandinavica, , Volume: 145, Issue:1, 2022
[Hallucinations in Patients with Idiopathic Parkinson's Disease].Fortschritte der Neurologie-Psychiatrie, , Volume: 90, Issue:10, 2022
Intranasal Exposure to Low-Dose Rotenone Induced Alpha-Synuclein Accumulation and Parkinson's Like Symptoms Without Loss of Dopaminergic Neurons.Neurotoxicity research, , Volume: 40, Issue:1, 2022
The role of cardiovascular autonomic failure in the differential diagnosis of α-synucleinopathies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 43, Issue:1, 2022
Gastrointestinal mucosal biopsies in Parkinson's disease: beyond alpha-synuclein detection.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 129, Issue:9, 2022
The increase of α-synuclein and alterations of dynein in A53T transgenic and aging mouse.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, , Volume: 96, 2022
Impact of α-synuclein spreading on the nigrostriatal dopaminergic pathway depends on the onset of the pathology.Brain pathology (Zurich, Switzerland), , Volume: 32, Issue:2, 2022
Pathology-associated change in levels and localization of SIDT2 in postmortem brains of Parkinson's disease and dementia with Lewy bodies patients.Neurochemistry international, , Volume: 152, 2022
Rescue of α-synuclein aggregation in Parkinson's patient neurons by synergistic enhancement of ER proteostasis and protein trafficking.Neuron, , 02-02, Volume: 110, Issue:3, 2022
α-Synuclein interacts differently with membranes mimicking the inner and outer leaflets of neuronal membranes.Biochimica et biophysica acta. Biomembranes, , 02-01, Volume: 1864, Issue:1, 2022
The influence of preconditioning with low dose of LPS on paraquat-induced neurotoxicity, microglia activation and expression of α-synuclein and synphilin-1 in the dopaminergic system.Pharmacological reports : PR, , Volume: 74, Issue:1, 2022
Glycoconjugate journal special issue on: the glycobiology of Parkinson's disease.Glycoconjugate journal, , Volume: 39, Issue:1, 2022
An Update on the Critical Role of α-Synuclein in Parkinson's Disease and Other Synucleinopathies: from Tissue to Cellular and Molecular Levels.Molecular neurobiology, , Volume: 59, Issue:1, 2022
The Compound ATH434 Prevents Alpha-Synuclein Toxicity in a Murine Model of Multiple System Atrophy.Journal of Parkinson's disease, , Volume: 12, Issue:1, 2022
Targeting alpha-synuclein via the immune system in Parkinson's disease: Current vaccine therapies.Neuropharmacology, , 01-01, Volume: 202, 2022
Astrocytic VEGFA: An essential mediator in blood-brain-barrier disruption in Parkinson's disease.Glia, , Volume: 70, Issue:2, 2022
Differentiating dementia with Lewy bodies from Alzheimer's disease and Parkinson's disease dementia: an update on imaging modalities.Journal of neurology, , Volume: 269, Issue:2, 2022
Ferruginol prevents degeneration of dopaminergic neurons by enhancing clearance of α-synuclein in neuronal cells.Fitoterapia, , Volume: 156, 2022
The potential neuroprotective effect of diosmin in rotenone-induced model of Parkinson's disease in rats.European journal of pharmacology, , Jan-05, Volume: 914, 2022
Disease-modifying treatment of Parkinson's disease by phytochemicals: targeting multiple pathogenic factors.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 129, Issue:5-6, 2022
Investigating the Roles of Heparan Sulfate Structures in Alpha-Synuclein Aggregation in Cell Culture Models.Methods in molecular biology (Clifton, N.J.), , Volume: 2303, 2022
The Two Faces of Exosomes in Parkinson's Disease: From Pathology to Therapy.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, , Volume: 28, Issue:2, 2022
LGALS3 (galectin 3) mediates an unconventional secretion of SNCA/α-synuclein in response to lysosomal membrane damage by the autophagic-lysosomal pathway in human midbrain dopamine neurons.Autophagy, , Volume: 18, Issue:5, 2022
Associations of sleep disorders with cerebrospinal fluid α-synuclein in prodromal and early Parkinson's disease.Journal of neurology, , Volume: 269, Issue:5, 2022
Neurotoxic or neuroprotective: Post-translational modifications of α-synuclein at the cross-roads of functions.Biochimie, , Volume: 192, 2022
Brain regions susceptible to alpha-synuclein spreading.Molecular psychiatry, , Volume: 27, Issue:1, 2022
A study on the interaction of the amyloid fibrils of α-synuclein and hen egg white lysozyme with biological membranes.Biochimica et biophysica acta. Biomembranes, , 02-01, Volume: 1864, Issue:1, 2022
Evaluating the role of ARSA in Chinese patients with Parkinson's disease.Neurobiology of aging, , Volume: 109, 2022
Metabolically induced intracellular pH changes activate mitophagy, autophagy, and cell protection in familial forms of Parkinson's disease.The FEBS journal, , Volume: 289, Issue:3, 2022
Targeting α-synuclein aggregation and its role in mitochondrial dysfunction in Parkinson's disease.British journal of pharmacology, , Volume: 179, Issue:1, 2022
Neurodegenerative Disorders and the Current State, Pathophysiology, and Management of Parkinson's Disease.CNS & neurological disorders drug targets, , Volume: 21, Issue:7, 2022
The Gut-Brain Axis: Two Ways Signaling in Parkinson's Disease.Cellular and molecular neurobiology, , Volume: 42, Issue:2, 2022
Emerging urinary alpha-synuclein and miRNA biomarkers in Parkinson's disease.Metabolic brain disease, , Volume: 37, Issue:6, 2022
The intestinal luminal sources of α-synuclein: a gastroenterologist perspective.Nutrition reviews, , 01-10, Volume: 80, Issue:2, 2022
Piperine promotes autophagy flux by P2RX4 activation in Autophagy, , Volume: 18, Issue:3, 2022
Structural and mechanistic insights into amyloid-β and α-synuclein fibril formation and polyphenol inhibitor efficacy in phospholipid bilayers.The FEBS journal, , Volume: 289, Issue:1, 2022
Innovative treatment targeting gangliosides aimed at blocking the formation of neurotoxic α-synuclein oligomers in Parkinson's disease.Glycoconjugate journal, , Volume: 39, Issue:1, 2022
α-Synuclein Selectively Impairs Motor Sequence Learning and Value Sensitivity: Reversal by the Adenosine A2A Receptor Antagonists.Cerebral cortex (New York, N.Y. : 1991), , 02-08, Volume: 32, Issue:4, 2022
Are Lysosomes Potential Therapeutic Targets for Parkinson's Disease?CNS & neurological disorders drug targets, , Volume: 21, Issue:8, 2022
Plasma total tau predicts executive dysfunction in Parkinson's disease.Acta neurologica Scandinavica, , Volume: 145, Issue:1, 2022
Impaired brain insulin signalling in Parkinson's disease.Neuropathology and applied neurobiology, , Volume: 48, Issue:1, 2022
Imaging protein aggregates in the serum and cerebrospinal fluid in Parkinson's disease.Brain : a journal of neurology, , 04-18, Volume: 145, Issue:2, 2022
Association Between Pathophysiological Mechanisms of Diabetic Retinopathy and Parkinson's Disease.Cellular and molecular neurobiology, , Volume: 42, Issue:3, 2022
The epigenetic mechanisms involved in mitochondrial dysfunction: Implication for Parkinson's disease.Brain pathology (Zurich, Switzerland), , Volume: 32, Issue:3, 2022
Apomorphine Reduces A53T α-Synuclein-Induced Microglial Reactivity Through Activation of NRF2 Signalling Pathway.Cellular and molecular neurobiology, , Volume: 42, Issue:8, 2022
Gut power: Modulation of human amyloid formation by amyloidogenic proteins in the gastrointestinal tract.Current opinion in structural biology, , Volume: 72, 2022
Potential treatment of Parkinson's disease with omega-3 polyunsaturated fatty acids.Nutritional neuroscience, , Volume: 25, Issue:1, 2022
The safety and effectiveness of α-synuclein immunotherapy vs. placebo for the treatment of Parkinson's disease: a systematic review and meta-analysis.Annals of palliative medicine, , Volume: 11, Issue:12, 2022
Targeting protein clearance pathways in Expert opinion on therapeutic targets, , Volume: 26, Issue:12, 2022
Expansion of regulatory T cells by CD28 superagonistic antibodies attenuates neurodegeneration in A53T-α-synuclein Parkinson's disease mice.Journal of neuroinflammation, , Dec-31, Volume: 19, Issue:1, 2022
Mechanisms of Autoimmune Cell in DA Neuron Apoptosis of Parkinson's Disease: Recent Advancement.Oxidative medicine and cellular longevity, , Volume: 2022, 2022
The Role of Membrane Affinity and Binding Modes in Alpha-Synuclein Regulation of Vesicle Release and Trafficking.Biomolecules, , 12-05, Volume: 12, Issue:12, 2022
Essential collective dynamics analysis reveals nonlocal interactions of alpha-synucleinThe Journal of chemical physics, , Dec-21, Volume: 157, Issue:23, 2022
MED13 and glycolysis are conserved modifiers of α-synuclein-associated neurodegeneration.Cell reports, , 12-20, Volume: 41, Issue:12, 2022
Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein.Scientific reports, , 12-19, Volume: 12, Issue:1, 2022
Neuronal haemoglobin induces loss of dopaminergic neurons in mouse Substantia nigra, cognitive deficits and cleavage of endogenous α-synuclein.Cell death & disease, , 12-16, Volume: 13, Issue:12, 2022
Granulovacuolar degeneration bodies are independently induced by tau and α-synuclein pathology.Alzheimer's research & therapy, , 12-14, Volume: 14, Issue:1, 2022
A Method to Study α-Synuclein Toxicity and Aggregation Using a Humanized Yeast Model.Journal of visualized experiments : JoVE, , Nov-25, Issue:189, 2022
Early-Onset Parkinson's Disease: Creating the Right Environment for a Genetic Disorder.Journal of Parkinson's disease, , Volume: 12, Issue:8, 2022
Modulation Effects of FeMolecules (Basel, Switzerland), , Dec-01, Volume: 27, Issue:23, 2022
Neuroinflammation and Autophagy in Parkinson's Disease-Novel Perspectives.International journal of molecular sciences, , Nov-30, Volume: 23, Issue:23, 2022
Ligand-Based Discovery of a Small Molecule as Inhibitor of α-Synuclein Amyloid Formation.International journal of molecular sciences, , Nov-27, Volume: 23, Issue:23, 2022
Antibodies against HSV-1 and Curli Show the Highest Correlation in Parkinson's Disease Patients in Comparison to Healthy Controls.International journal of molecular sciences, , Nov-26, Volume: 23, Issue:23, 2022
Pathogenesis of α-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective.International journal of molecular sciences, , Nov-25, Volume: 23, Issue:23, 2022
Structural and Biophysical Characterization of Stable Alpha-Synuclein Oligomers.International journal of molecular sciences, , Nov-23, Volume: 23, Issue:23, 2022
A Single Chain Fragment Variant Binding Misfolded Alpha-Synuclein Exhibits Neuroprotective and Antigen-Specific Anti-Inflammatory Properties.Cells, , Nov-29, Volume: 11, Issue:23, 2022
UBA52 Is Crucial in HSP90 Ubiquitylation and Neurodegenerative Signaling during Early Phase of Parkinson's Disease.Cells, , Nov-25, Volume: 11, Issue:23, 2022
Parkinson's disease drug hunters think outside the α-synuclein box.Nature biotechnology, , Volume: 40, Issue:12, 2022
Axonal degeneration in the anterior insular cortex is associated with Alzheimer's co-pathology in Parkinson's disease and dementia with Lewy bodies.Translational neurodegeneration, , 12-07, Volume: 11, Issue:1, 2022
Observation of α-Synuclein Preformed Fibrils Interacting with SH-SY5Y Neuroblastoma Cell Membranes Using Scanning Ion Conductance Microscopy.ACS chemical neuroscience, , 12-21, Volume: 13, Issue:24, 2022
Patient-derived three-dimensional cortical neurospheres to model Parkinson's disease.PloS one, , Volume: 17, Issue:12, 2022
Correlation between α-synuclein and fatty acid composition in jejunum of rotenone-treated mice is dependent on acyl chain length.General physiology and biophysics, , Volume: 41, Issue:6, 2022
Monoclonal Antibodies in Neurodegenerative Disease May Work, But They Don't Help: A Perspective from Physicians.Journal of Parkinson's disease, , Volume: 12, Issue:8, 2022
Probiotic Frontiers in cellular and infection microbiology, , Volume: 12, 2022
Intronic enhancers of the human Science advances, , 11-25, Volume: 8, Issue:47, 2022
Intracellular Accumulation of α-Synuclein Aggregates Promotes S-Nitrosylation of MAP1A Leading to Decreased NMDAR-Evoked Calcium Influx and Loss of Mature Synaptic Spines.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 12-14, Volume: 42, Issue:50, 2022
Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry Approach to Correlate Local Structure and Aggregation in α-Synuclein.Analytical chemistry, , 12-06, Volume: 94, Issue:48, 2022
This is NOT the End for Immunotherapy in Parkinson's Disease - A Perspective from Early Drug Development Scientists.Journal of Parkinson's disease, , Volume: 12, Issue:8, 2022
Human pericytes degrade diverse α-synuclein aggregates.PloS one, , Volume: 17, Issue:11, 2022
α-Synuclein Disrupts Vesicle Fusion by Two Mutant-Specific Mechanisms.Molecules and cells, , Nov-30, Volume: 45, Issue:11, 2022
Concerted enhanced-sampling simulations to elucidate the helix-fibril transition pathway of intrinsically disordered α-Synuclein.International journal of biological macromolecules, , Dec-31, Volume: 223, Issue:Pt A, 2022
Ubiquitin-positive astrogliopathy clinically mimicking Parkinson's disease.Acta neuropathologica communications, , 11-14, Volume: 10, Issue:1, 2022
Phase separation and other forms of α-Synuclein self-assemblies.Essays in biochemistry, , 12-16, Volume: 66, Issue:7, 2022
Phosphorylated α-Synuclein Deposits in Cutaneous Nerves of Early Parkinsonism.Journal of Parkinson's disease, , Volume: 12, Issue:8, 2022
DOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomers.Nature communications, , 11-12, Volume: 13, Issue:1, 2022
Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders.Acta neuropathologica communications, , 11-12, Volume: 10, Issue:1, 2022
A penetratin-derived peptide reduces the membrane permeabilization and cell toxicity of α-synuclein oligomers.The Journal of biological chemistry, , Volume: 298, Issue:12, 2022
Gastric Enteric Glial Cells: A New Contributor to the Synucleinopathies in the MPTP-Induced Parkinsonism Mouse.Molecules (Basel, Switzerland), , Nov-01, Volume: 27, Issue:21, 2022
AmyP53, a Therapeutic Peptide Candidate for the Treatment of Alzheimer's and Parkinson's Disease: Safety, Stability, Pharmacokinetics Parameters and Nose-to Brain Delivery.International journal of molecular sciences, , Nov-02, Volume: 23, Issue:21, 2022
[no title available]International journal of molecular sciences, , Oct-28, Volume: 23, Issue:21, 2022
Molecular and Cellular Interactions in Pathogenesis of Sporadic Parkinson Disease.International journal of molecular sciences, , Oct-27, Volume: 23, Issue:21, 2022
Glymphatic System Dysfunction and Sleep Disturbance May Contribute to the Pathogenesis and Progression of Parkinson's Disease.International journal of molecular sciences, , Oct-26, Volume: 23, Issue:21, 2022
The 3D structure of lipidic fibrils of α-synuclein.Nature communications, , 11-10, Volume: 13, Issue:1, 2022
Moderate Binding between Two SARS-CoV-2 Protein Segments and α-Synuclein Alters Its Toxic Oligomerization Propensity Differently.The journal of physical chemistry letters, , Nov-17, Volume: 13, Issue:45, 2022
Interactions of dopamine, iron, and alpha-synuclein linked to dopaminergic neuron vulnerability in Parkinson's disease and Neurodegeneration with Brain Iron Accumulation disorders.Neurobiology of disease, , Volume: 175, 2022
Inhibition of α-Synuclein Seeding-Dependent Aggregation by ssDNA Aptamers Specific to C-Terminally Truncated α-Synuclein Fibrils.ACS chemical neuroscience, , 12-07, Volume: 13, Issue:23, 2022
A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice.eLife, , 11-08, Volume: 11, 2022
[Role of fatty acid-binding protein 7 and novel therapeutic approach in synucleinopathies].Nihon yakurigaku zasshi. Folia pharmacologica Japonica, , Volume: 157, Issue:6, 2022
The Glycoprotein GPNMB: A Secret Ingredient for Understanding Parkinson's Disease Etiology?Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:12, 2022
α-Synuclein upregulates bim-mediated apoptosis by negatively regulating endogenous GCN5.Aging, , 10-27, Volume: 14, Issue:20, 2022
SIAH proteins regulate the degradation and intra-mitochondrial aggregation of PINK1: Implications for mitochondrial pathology in Parkinson's disease.Aging cell, , Volume: 21, Issue:12, 2022
Non-Reproducibility of Oral Rotenone as a Model for Parkinson's Disease in Mice.International journal of molecular sciences, , Oct-21, Volume: 23, Issue:20, 2022
Relationship between Substantia Nigra Neuromelanin Imaging and Dual Alpha-Synuclein Labeling of Labial Minor in Salivary Glands in Isolated Rapid Eye Movement Sleep Behavior Disorder and Parkinson's Disease.Genes, , Sep-24, Volume: 13, Issue:10, 2022
Relevance of plasma biomarkers to pathologies in Alzheimer's disease, Parkinson's disease and frontotemporal dementia.Scientific reports, , 10-26, Volume: 12, Issue:1, 2022
Regulation of α-synuclein homeostasis and inflammasome activation by microglial autophagy.Science advances, , 10-28, Volume: 8, Issue:43, 2022
Pharmacological inhibition of AIMP2 aggregation attenuates α-synuclein aggregation and toxicity in Parkinson's disease.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 156, 2022
D-π-A-Based Trisubstituted Alkenes as Environmentally Sensitive Fluorescent Probes to Detect Lewy Pathologies.Analytical chemistry, , 11-08, Volume: 94, Issue:44, 2022
An HPLC-UV validated bioanalytical method for measurement of Xenobiotica; the fate of foreign compounds in biological systems, , Volume: 52, Issue:8, 2022
Human gut microbiota and Parkinson's disease.Progress in molecular biology and translational science, , Volume: 192, Issue:1, 2022
[A role of human microbiota in the development of neurodegenerative diseases].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, , Volume: 122, Issue:10, 2022
A Conceptual Study on the Peripheral Clearance of Brain-Derived α-Synuclein in Humans.Journal of Alzheimer's disease : JAD, , Volume: 90, Issue:4, 2022
Identification of exosomal biomarkers and its optimal isolation and detection method for the diagnosis of Parkinson's disease: A systematic review and meta-analysis.Ageing research reviews, , Volume: 82, 2022
Reelin protects against pathological α-synuclein accumulation and dopaminergic neurodegeneration after environmental enrichment in Parkinson's disease.Neurobiology of disease, , Volume: 175, 2022
Effects of Mutations and Post-Translational Modifications on α-Synuclein In Vitro Aggregation.Journal of molecular biology, , 12-15, Volume: 434, Issue:23, 2022
Identification of Drug-Disease Associations Using a Random Walk with Restart Method and Supervised Learning.Computational and mathematical methods in medicine, , Volume: 2022, 2022
Modeling native and seeded Synuclein aggregation and related cellular dysfunctions in dopaminergic neurons derived by a new set of isogenic iPSC lines with SNCA multiplications.Cell death & disease, , 10-19, Volume: 13, Issue:10, 2022
Intestine-derived α-synuclein initiates and aggravates pathogenesis of Parkinson's disease in Drosophila.Translational neurodegeneration, , 10-17, Volume: 11, Issue:1, 2022
Development of an α-synuclein fibril and oligomer specific tracer for diagnosis of Parkinson's disease, dementia with Lewy bodies and multiple system atrophy.Neurochemistry international, , Volume: 161, 2022
Early α-synuclein aggregation is overall delayed and it can occur by a stepwise mechanism.Biochemical and biophysical research communications, , 12-20, Volume: 635, 2022
Liquid-Liquid Phase Separation Promotes Protein Aggregation and Its Implications in Ferroptosis in Parkinson's Disease Dementia.Oxidative medicine and cellular longevity, , Volume: 2022, 2022
The Potential Role of Voltage-Dependent Anion Channel in the Treatment of Parkinson's Disease.Oxidative medicine and cellular longevity, , Volume: 2022, 2022
Pericytes take up and degrade α-synuclein but succumb to apoptosis under cellular stress.Scientific reports, , 10-15, Volume: 12, Issue:1, 2022
EGCG has Dual and Opposing Effects on the N-terminal Region of Self-associating α-synuclein Oligomers.Journal of molecular biology, , 12-15, Volume: 434, Issue:23, 2022
Saposin C, Key Regulator in the Alpha-Synuclein Degradation Mediated by Lysosome.International journal of molecular sciences, , Oct-09, Volume: 23, Issue:19, 2022
The Potential Roles of Extracellular Vesicles as Biomarkers for Parkinson's Disease: A Systematic Review.International journal of molecular sciences, , Sep-29, Volume: 23, Issue:19, 2022
[Cells, , 09-30, Volume: 11, Issue:19, 2022
Modulatory Role of TPPP3 in Microtubule Organization and Its Impact on Alpha-Synuclein Pathology.Cells, , 09-27, Volume: 11, Issue:19, 2022
ATPase Thorase Deficiency Causes α-Synucleinopathy and Parkinson's Disease-like Behavior.Cells, , 09-26, Volume: 11, Issue:19, 2022
Erythrocytic alpha-synuclein in early Parkinson's disease: A 3-year longitudinal study.Parkinsonism & related disorders, , Volume: 104, 2022
Fucosylated Chondroitin Sulfate against Parkinson's Disease through Inhibiting Inflammation Induced by Gut Dysbiosis.Journal of agricultural and food chemistry, , Oct-26, Volume: 70, Issue:42, 2022
Association between LAG3/CD4 gene variants and risk of Parkinson's disease.European journal of clinical investigation, , Volume: 52, Issue:11, 2022
Global, in situ analysis of the structural proteome in individuals with Parkinson's disease to identify a new class of biomarker.Nature structural & molecular biology, , Volume: 29, Issue:10, 2022
Diagnosis and Treatment of Cognitive and Neuropsychiatric Symptoms in Parkinson Disease and Dementia With Lewy Bodies.Continuum (Minneapolis, Minn.), , Oct-01, Volume: 28, Issue:5, 2022
Development of a Systematic Strategy toward Promotion of α-Synuclein Aggregation Using 2-Hydroxyisophthalamide-Based Systems.Biochemistry, , 11-01, Volume: 61, Issue:21, 2022
Single-cell RNA sequencing of CSF reveals neuroprotective RAC1Frontiers in immunology, , Volume: 13, 2022
Smell deficits in COVID-19 and possible links with Parkinson's disease.International review of neurobiology, , Volume: 165, 2022
Anionic lipid vesicles have differential effects on the aggregation of early onset-associated α-synuclein missense mutants.The Journal of biological chemistry, , Volume: 298, Issue:12, 2022
Aggregation-Seeding Forms of α-Synuclein Are Not Detected in Acute Coronavirus Disease 2019 Cerebrospinal Fluid.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:12, 2022
Quantitative super-resolution imaging of pathological aggregates reveals distinct toxicity profiles in different synucleinopathies.Proceedings of the National Academy of Sciences of the United States of America, , 10-11, Volume: 119, Issue:41, 2022
Microbiota- Brain-Gut-Axis Relevance to Parkinson's Disease: Potential Therapeutic Effects of Probiotics.Current pharmaceutical design, , Volume: 28, Issue:37, 2022
Rapid restructurization of conformationally-distinct alpha-synuclein amyloid fibrils at an elevated temperature.PeerJ, , Volume: 10, 2022
Is there a halo-enzymopathy in Parkinson's disease?Neurologia, , Volume: 37, Issue:8, 2022
A Combined α-Synuclein/Fibril (SynFib) Model of Parkinson-Like Synucleinopathy Targeting the Nigrostriatal Dopamine System.Journal of Parkinson's disease, , Volume: 12, Issue:8, 2022
Progress in Parkinson's disease animal models of genetic defects: Characteristics and application.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 155, 2022
Quaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein.Communications biology, , 09-30, Volume: 5, Issue:1, 2022
High-content phenotyping of Parkinson's disease patient stem cell-derived midbrain dopaminergic neurons using machine learning classification.Stem cell reports, , 10-11, Volume: 17, Issue:10, 2022
AMPK-dependent autophagy activation and alpha-Synuclein clearance: a putative mechanism behind alpha-mangostin's neuroprotection in a rotenone-induced mouse model of Parkinson's disease.Metabolic brain disease, , Volume: 37, Issue:8, 2022
Regulation of Parkinson's disease-associated genes by Pumilio proteins and microRNAs in SH-SY5Y neuronal cells.PloS one, , Volume: 17, Issue:9, 2022
Retrograde Axonal Autophagy and Endocytic Pathways Are Parallel and Separate in Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 11-09, Volume: 42, Issue:45, 2022
6-Hydroxydopamine-Induced Neurotoxicity in Rat Model of Parkinson's Disease: Is Reversed via Anti-Oxidative Activities of Curcumin and Aerobic Exercise Therapy.Physiological research, , Aug-31, Volume: 71, Issue:4, 2022
Thoracic trauma promotes alpha-Synuclein oligomerization in murine Parkinson's disease.Neurobiology of disease, , Volume: 174, 2022
Early Dysbiosis and Dampened Gut Microbe Oscillation Precede Motor Dysfunction and Neuropathology in Animal Models of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:8, 2022
First trials test targeting of α-synuclein for Parkinson disease.Nature reviews. Neurology, , Volume: 18, Issue:12, 2022
α-Syn overexpression, NRF2 suppression, and enhanced ferroptosis create a vicious cycle of neuronal loss in Parkinson's disease.Free radical biology & medicine, , 11-01, Volume: 192, 2022
Age-related pathological impairments in directly reprogrammed dopaminergic neurons derived from patients with idiopathic Parkinson's disease.Stem cell reports, , 10-11, Volume: 17, Issue:10, 2022
Pattern of Mitochondrial Respiration in Peripheral Blood Cells of Patients with Parkinson's Disease.International journal of molecular sciences, , Sep-17, Volume: 23, Issue:18, 2022
Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson's Disease.International journal of molecular sciences, , Sep-16, Volume: 23, Issue:18, 2022
The Effect of Aggregated Alpha Synuclein on Synaptic and Axonal Proteins in Parkinson's Disease-A Systematic Review.Biomolecules, , 08-29, Volume: 12, Issue:9, 2022
Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia.Cell reports, , 09-20, Volume: 40, Issue:12, 2022
Small soluble α-synuclein aggregates are the toxic species in Parkinson's disease.Nature communications, , 09-20, Volume: 13, Issue:1, 2022
Direct Observation of "Elongated" Conformational States in α-Synuclein upon Liquid-Liquid Phase Separation.Angewandte Chemie (International ed. in English), , 11-14, Volume: 61, Issue:46, 2022
Idiopathic rapid eye movement sleep behavior disorder in Japan: An observational study.Parkinsonism & related disorders, , Volume: 103, 2022
Propagation of Parkinson's disease by extracellular vesicle production and secretion.Biochemical Society transactions, , 10-31, Volume: 50, Issue:5, 2022
Neuroprotective effects of cannabidiol on dopaminergic neurodegeneration and α-synuclein accumulation in C. elegans models of Parkinson's disease.Neurotoxicology, , Volume: 93, 2022
Structures of α-synuclein filaments from human brains with Lewy pathology.Nature, , Volume: 610, Issue:7933, 2022
Paraquat exposure induces Parkinsonism by altering lipid profile and evoking neuroinflammation in the midbrain.Environment international, , Volume: 169, 2022
Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases.BioEssays : news and reviews in molecular, cellular and developmental biology, , Volume: 44, Issue:11, 2022
Involvement of heat shock proteins and parkin/α-synuclein axis in Parkinson's disease.Molecular biology reports, , Volume: 49, Issue:11, 2022
Disease-Associated α-Synuclein Aggregates as Biomarkers of Parkinson Disease Clinical Stage.Neurology, , 11-22, Volume: 99, Issue:21, 2022
Fenofibrate promotes neuroprotection in a model of rotenone-induced Parkinson's disease.Behavioural pharmacology, , 12-01, Volume: 33, Issue:8, 2022
Exploring the Paradox of COVID-19 in Neurological Complications with Emphasis on Parkinson's and Alzheimer's Disease.Oxidative medicine and cellular longevity, , Volume: 2022, 2022
Hemoglobin-binding α-synuclein levels in erythrocytes are elevated in patients with multiple system atrophy.Neuroscience letters, , 10-15, Volume: 789, 2022
Exposure to the environmentally toxic pesticide maneb induces Parkinson's disease-like neurotoxicity in mice: A combined proteomic and metabolomic analysis.Chemosphere, , Volume: 308, Issue:Pt 2, 2022
Detection of α-Synuclein-Specific T Cells in Parkinson's Disease.Methods in molecular biology (Clifton, N.J.), , Volume: 2574, 2022
Homozygous CADPS2 Mutations Cause Neurodegenerative Disease with Lewy Body-like Pathology in Parrots.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:12, 2022
Transmembrane protein interacts with α-synuclein to confer risk of PD.Nature reviews. Neurology, , Volume: 18, Issue:10, 2022
Alpha-synuclein Immunization Strategies for Synucleinopathies in Clinical Studies: A Biological Perspective.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 19, Issue:5, 2022
The Intranigral Infusion of Human-Alpha Synuclein Oligomers Induces a Cognitive Impairment in Rats Associated with Changes in Neuronal Firing and Neuroinflammation in the Anterior Cingulate Cortex.Cells, , 08-24, Volume: 11, Issue:17, 2022
Neuropathology of the Basal Ganglia in SNCA Transgenic Rat Model of Parkinson's Disease: Involvement of Parvalbuminergic Interneurons and Glial-Derived Neurotropic Factor.International journal of molecular sciences, , Sep-04, Volume: 23, Issue:17, 2022
Alpha-Synuclein: The Spark That Flames Dopaminergic Neurons, In Vitro and In Vivo Evidence.International journal of molecular sciences, , Aug-30, Volume: 23, Issue:17, 2022
Post-COVID-19 Parkinsonism and Parkinson's Disease Pathogenesis: The Exosomal Cargo Hypothesis.International journal of molecular sciences, , Aug-28, Volume: 23, Issue:17, 2022
Mitochondrial dysfunction is a key pathological driver of early stage Parkinson's.Acta neuropathologica communications, , 09-08, Volume: 10, Issue:1, 2022
Discrepancy between distribution of alpha-synuclein oligomers and Lewy-related pathology in Parkinson's disease.Acta neuropathologica communications, , 09-06, Volume: 10, Issue:1, 2022
Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD.Molecular neurodegeneration, , 09-05, Volume: 17, Issue:1, 2022
Inhibition of α-synuclein aggregation by MT101-5 is neuroprotective in mouse models of Parkinson's disease.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 154, 2022
LRP1 is a neuronal receptor for α-synuclein uptake and spread.Molecular neurodegeneration, , 09-02, Volume: 17, Issue:1, 2022
Nanozyme-based cascade SPR signal amplification for immunosensing of nitrated alpha-synuclein.Mikrochimica acta, , 09-02, Volume: 189, Issue:10, 2022
Fine Particulate Matter Triggers α-Synuclein Fibrillization and Parkinson-like Neurodegeneration.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:9, 2022
Exploring Structural Flexibility and Stability of α-Synuclein by the Landau-Ginzburg-Wilson Approach.The journal of physical chemistry. B, , 09-15, Volume: 126, Issue:36, 2022
Adaptive structural changes in the motor cortex and white matter in Parkinson's disease.Acta neuropathologica, , Volume: 144, Issue:5, 2022
Ghrelin Bridges DMV Neuropathology and GI Dysfunction in the Early Stages of Parkinson's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany), , Volume: 9, Issue:30, 2022
Chlorogenic Acid: a Polyphenol from Coffee Rendered Neuroprotection Against Rotenone-Induced Parkinson's Disease by GLP-1 Secretion.Molecular neurobiology, , Volume: 59, Issue:11, 2022
Different patterns of exosomal α-synuclein between Parkinson's disease and probable rapid eye movement sleep behavior disorder.European journal of neurology, , Volume: 29, Issue:12, 2022
Neuronal hyperactivity-induced oxidant stress promotes in vivo α-synuclein brain spreading.Science advances, , 09-02, Volume: 8, Issue:35, 2022
Amelioration of pathologic α-synuclein-induced Parkinson's disease by irisin.Proceedings of the National Academy of Sciences of the United States of America, , 09-06, Volume: 119, Issue:36, 2022
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity.Nature neuroscience, , Volume: 25, Issue:9, 2022
Type 2 diabetes mellitus augments Parkinson's disease risk or the other way around: Facts, challenges and future possibilities.Ageing research reviews, , Volume: 81, 2022
Neuroinflammation in Parkinson's Disease and its Treatment Opportunities.Balkan medical journal, , 09-09, Volume: 39, Issue:5, 2022
In vivo and autopsy validation of alpha-synuclein seeding activity using RT-QuIC assay in the gastrointestinal tract of patients with Parkinson's disease.Parkinsonism & related disorders, , Volume: 103, 2022
Post-translational Modifications in Parkinson's Disease.Advances in experimental medicine and biology, , Volume: 1382, 2022
Family History for Neurodegeneration in Multiple System Atrophy: Does it Indicate Susceptibility?Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:11, 2022
Physiological and Pathological Functions of Neuronal Hemoglobin: A Key Underappreciated Protein in Parkinson's Disease.International journal of molecular sciences, , Aug-13, Volume: 23, Issue:16, 2022
Translocation of Distinct Alpha Synuclein Species from the Nucleus to Neuronal Processes during Neuronal Differentiation.Biomolecules, , 08-12, Volume: 12, Issue:8, 2022
Single residue modulators of amyloid formation in the N-terminal P1-region of α-synuclein.Nature communications, , 08-25, Volume: 13, Issue:1, 2022
Examination of Abnormal Alpha-synuclein Aggregates in the Enteric Neural Plexus in Patients with Ulcerative Colitis.Journal of gastrointestinal and liver diseases : JGLD, , 09-15, Volume: 31, Issue:3, 2022
Alpha synuclein determines ferroptosis sensitivity in dopaminergic neurons via modulation of ether-phospholipid membrane composition.Cell reports, , 08-23, Volume: 40, Issue:8, 2022
Untwisted α-Synuclein Filaments Formed in the Presence of Lipid Vesicles.Biochemistry, , 09-06, Volume: 61, Issue:17, 2022
Skeletal Muscle is a Source of α-Synuclein with a Sarcolemmal Non-Lipid Raft Distribution.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , Aug-25, Volume: 56, Issue:4, 2022
Threonine Cavities Are Targetable Motifs That Control Alpha-Synuclein Fibril Growth.ACS chemical neuroscience, , 09-07, Volume: 13, Issue:17, 2022
Multiple checkpoints of protein clearance machinery are modulated by a common microRNA, miR-4813-3p, through its putative target genes: Studies employing transgenic C. elegans model.Biochimica et biophysica acta. Molecular cell research, , Volume: 1869, Issue:12, 2022
JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species.Neurotoxicity research, , Volume: 40, Issue:6, 2022
Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology.Nature communications, , 08-22, Volume: 13, Issue:1, 2022
Lewy Body Disease Primate Model with α-Synuclein Propagation from the Olfactory Bulb.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:10, 2022
Role of NLRP3 Inflammasome in Parkinson's Disease and Therapeutic Considerations.Journal of Parkinson's disease, , Volume: 12, Issue:7, 2022
Identification of a biological excimer involving protein-protein interactions: A case study of the α-synuclein aggregation.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, , Dec-15, Volume: 283, 2022
Natural speech markers of Alzheimer's disease co-pathology in Lewy body dementias.Parkinsonism & related disorders, , Volume: 102, 2022
Systemic RNA Interference Defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans.PLoS genetics, , Volume: 18, Issue:8, 2022
Baicalein exhibits differential effects and mechanisms towards disruption of α-synuclein fibrils with different polymorphs.International journal of biological macromolecules, , Nov-01, Volume: 220, 2022
GPNMB confers risk for Parkinson's disease through interaction with α-synuclein.Science (New York, N.Y.), , 08-19, Volume: 377, Issue:6608, 2022
Reply to: "Could Blood Hexosylsphingosine Be a Marker for Parkinson's Disease Linked with GBA1 Mutations"?Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:8, 2022
Reply to: "Overlapping Ranges in Levels Indicate That Hexosylsphingosine Is Not a Clinically Relevant Biomarker for GBA1-Associated Parkinson's Disease".Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:8, 2022
De novo designed protein inhibitors of amyloid aggregation and seeding.Proceedings of the National Academy of Sciences of the United States of America, , 08-23, Volume: 119, Issue:34, 2022
Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein.Journal of visualized experiments : JoVE, , 07-29, Issue:185, 2022
A task-specific cognitive domain decline is correlated with plasma and neuroimaging markers in patients with Parkinson's disease.Journal of neurology, , Volume: 269, Issue:12, 2022
Removal of proteinase K resistant αSyn species does not correlate with cell survival in a virus vector-based Parkinson's disease mouse model.Neuropharmacology, , 11-01, Volume: 218, 2022
Constipation distinguishes different clinical-biochemical patterns in de novo Parkinson's disease.Parkinsonism & related disorders, , Volume: 102, 2022
Modulation of Inflammatory Mediators and Microglial Activation Through Physical Exercise in Alzheimer's and Parkinson's Diseases.Neurochemical research, , Volume: 47, Issue:11, 2022
Measurement of α-Synuclein Dynamics In Vivo Using Microdialysis with a Novel Homogeneous Immunoassay.ACS chemical neuroscience, , 09-07, Volume: 13, Issue:17, 2022
Phase 1/1b Studies of UCB0599, an Oral Inhibitor of α-Synuclein Misfolding, Including a Randomized Study in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:10, 2022
Synthetic Peucedanocoumarin IV Prevents α-Synuclein Neurotoxicity in an Animal Model of Parkinson's Disease.International journal of molecular sciences, , Aug-03, Volume: 23, Issue:15, 2022
Increased Expression of Alpha-, Beta-, and Gamma-Synucleins in Brainstem Regions of a Non-Human Primate Model of Parkinson's Disease.International journal of molecular sciences, , Aug-02, Volume: 23, Issue:15, 2022
Neuronal ApoE Regulates the Cell-to-Cell Transmission of α-Synuclein.International journal of molecular sciences, , Jul-27, Volume: 23, Issue:15, 2022
CuJournal of inorganic biochemistry, , Volume: 236, 2022
Alteration of Vesicle-Associated Membrane Protein-Binding Protein B in α-Synuclein Aggregates in Lewy Body Disease.Journal of neuropathology and experimental neurology, , 09-19, Volume: 81, Issue:10, 2022
Characterizing Lewy Pathology in 231 Essential Tremor Brains From the Essential Tremor Centralized Brain Repository.Journal of neuropathology and experimental neurology, , 09-19, Volume: 81, Issue:10, 2022
C-terminal truncation modulates α-Synuclein's cytotoxicity and aggregation by promoting the interactions with membrane and chaperone.Communications biology, , 08-09, Volume: 5, Issue:1, 2022
Extracellular vesicles and seeding amplification: a step closer to a Parkinson's disease blood test.Brain : a journal of neurology, , 09-14, Volume: 145, Issue:9, 2022
Gray Matter Volume Loss in Proposed Brain-First and Body-First Parkinson's Disease Subtypes.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:10, 2022
[Ascendance of Abnormal α-synuclein Fibrils Through the Vagal Nerve in Parkinson's Disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 74, Issue:8, 2022
Synaptic Neurofilaments and GluN1-Neurofilament Light Chain Interaction in Experimental Models of α-Synucleinopathies.Neuro-degenerative diseases, , Volume: 22, Issue:1, 2022
B Lymphocytes in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
Glucocerebrosidase mutations and Parkinson disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 129, Issue:9, 2022
Designer D-peptides targeting the N-terminal region of α-synuclein to prevent parkinsonian-associated fibrilization and cytotoxicity.Biochimica et biophysica acta. Proteins and proteomics, , 10-01, Volume: 1870, Issue:10, 2022
4-Phenylbutyrate Mitigates the Motor Impairment and Dopaminergic Neuronal Death During Parkinson's Disease Pathology via Targeting VDAC1 Mediated Mitochondrial Function and Astrocytes Activation.Neurochemical research, , Volume: 47, Issue:11, 2022
Involvement of autophagic protein DEF8 in Lewy bodies.Biochemical and biophysical research communications, , 10-01, Volume: 623, 2022
Trial of Prasinezumab in Early-Stage Parkinson's Disease.The New England journal of medicine, , 08-04, Volume: 387, Issue:5, 2022
Trial of Cinpanemab in Early Parkinson's Disease.The New England journal of medicine, , 08-04, Volume: 387, Issue:5, 2022
Rabphilin-3A as a novel target to reverse α-synuclein-induced synaptic loss in Parkinson's disease.Pharmacological research, , Volume: 183, 2022
Polygenic risk prediction and SNCA haplotype analysis in a Latino Parkinson's disease cohort.Parkinsonism & related disorders, , Volume: 102, 2022
The Zinc Ionophore Clioquinol Reduces Parkinson's Disease Patient-Derived Brain Extracts-Induced Neurodegeneration.Molecular neurobiology, , Volume: 59, Issue:10, 2022
α-Synuclein Seed Amplification Assays for Diagnosing Synucleinopathies: The Way Forward.Neurology, , 08-02, Volume: 99, Issue:5, 2022
Dual Effects: Intrastriatal Injection of α-syn N103/tau N368 Preformed Fibrils Promotes Endogenous α-synuclein Aggregates in the Proximal Colon.Journal of Parkinson's disease, , Volume: 12, Issue:7, 2022
Pathological substrate of memory impairment in multiple system atrophy.Neuropathology and applied neurobiology, , Volume: 48, Issue:7, 2022
Functional Cooperation of α-Synuclein and Tau Is Essential for Proper Corticogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 09-14, Volume: 42, Issue:37, 2022
Is peripheral alpha synuclein a marker for gait velocity in Parkinson's disease?Neuroscience letters, , 08-24, Volume: 786, 2022
Modeling the dynamics of innate immune response to Parkinson disease with therapeutic approach.Physical biology, , 08-18, Volume: 19, Issue:5, 2022
NXP031 prevents dopaminergic neuronal loss and oxidative damage in the AAV-WT-α-synuclein mouse model of Parkinson's disease.PloS one, , Volume: 17, Issue:7, 2022
Influence of heavy metals in Parkinson's disease: an overview.Journal of neurology, , Volume: 269, Issue:11, 2022
Inhibition of Ubiquitin-Specific Protease-13 Improves Behavioral Performance in Alpha-Synuclein Expressing Mice.International journal of molecular sciences, , Jul-23, Volume: 23, Issue:15, 2022
Parkinson's Disease Etiology: Insights and Associations with Phosphate Toxicity.International journal of molecular sciences, , Jul-22, Volume: 23, Issue:15, 2022
Recent advances in establishing fluid biomarkers for the diagnosis and differentiation of alpha-synucleinopathies - a mini review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 32, Issue:4, 2022
Exogenous Tetranectin Alleviates Pre-formed-fibrils-induced Synucleinopathies in SH-SY5Y Cells by Activating the Plasminogen Activation System.Neurochemical research, , Volume: 47, Issue:10, 2022
Dysregulation of peripheral monocytes and pro-inflammation of alpha-synuclein in Parkinson's disease.Journal of neurology, , Volume: 269, Issue:12, 2022
α-Synuclein V15A Variant in Familial Parkinson's Disease Exhibits a Weaker Lipid-Binding Property.Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:10, 2022
α-Synuclein Conformational Plasticity: Physiologic States, Pathologic Strains, and Biotechnological Applications.Biomolecules, , 07-17, Volume: 12, Issue:7, 2022
Exosomes in Alpha-Synucleinopathies: Propagators of Pathology or Potential Candidates for Nanotherapeutics?Biomolecules, , 07-08, Volume: 12, Issue:7, 2022
Early Signs of Molecular Defects in iPSC-Derived Neural Stems Cells from Patients with Familial Parkinson's Disease.Biomolecules, , 06-23, Volume: 12, Issue:7, 2022
Association of Cerebrospinal Fluid Neurofilament Heavy Protein Levels With Clinical Progression in Patients With Parkinson Disease.JAMA network open, , 07-01, Volume: 5, Issue:7, 2022
Therapeutic Strategies for Immune Transformation in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
A FRET-based aptasensor for the detection of α-synuclein oligomers as biomarkers of Parkinson's disease.Analytical methods : advancing methods and applications, , 08-04, Volume: 14, Issue:30, 2022
Rapid macropinocytic transfer of α-synuclein to lysosomes.Cell reports, , 07-19, Volume: 40, Issue:3, 2022
Targets for astrocyte-based treatments of Parkinson's disease (PD).Proceedings of the National Academy of Sciences of the United States of America, , 07-26, Volume: 119, Issue:30, 2022
Therapeutic functions of astrocytes to treat α-synuclein pathology in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 07-19, Volume: 119, Issue:29, 2022
A versatile fluorescence-quenched substrate for quantitative measurement of glucocerebrosidase activity within live cells.Proceedings of the National Academy of Sciences of the United States of America, , 07-19, Volume: 119, Issue:29, 2022
Deciphering Intertwined Molecular Pathways Underlying Metabolic Syndrome Leading to Parkinson's Disease.ACS chemical neuroscience, , 08-03, Volume: 13, Issue:15, 2022
α-Synuclein fibril-specific nanobody reduces prion-like α-synuclein spreading in mice.Nature communications, , 07-19, Volume: 13, Issue:1, 2022
α-Synuclein PET and Parkinson Disease Therapeutic Trials: Ever the Twain Shall Meet?Journal of nuclear medicine : official publication, Society of Nuclear Medicine, , Volume: 63, Issue:10, 2022
Inflammasome Activation in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
MANF Inhibits Oxidative medicine and cellular longevity, , Volume: 2022, 2022
Absence of Gem1 (mammalian Miro/Rhot) mitigates alpha-synuclein toxicity in a yeast model of Parkinson's disease.Molecular and cellular neurosciences, , Volume: 122, 2022
A small molecule toll-like receptor antagonist rescues α-synuclein fibril pathology.The Journal of biological chemistry, , Volume: 298, Issue:8, 2022
17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson's disease are associated with LRRC37A/2 expression in astrocytes.Molecular neurodegeneration, , 07-15, Volume: 17, Issue:1, 2022
Optimizing Epitope Conformational Ensembles Using α-Synuclein Cyclic Peptide "Glycindel" Scaffolds: A Customized Immunogen Method for Generating Oligomer-Selective Antibodies for Parkinson's Disease.ACS chemical neuroscience, , 08-03, Volume: 13, Issue:15, 2022
Diagnostic and therapeutic agents that target alpha-synuclein in Parkinson's disease.Journal of neurology, , Volume: 269, Issue:11, 2022
Bivalent metal ions induce formation of α-synuclein fibril polymorphs with different cytotoxicities.Scientific reports, , 07-13, Volume: 12, Issue:1, 2022
Parkinson's disease risk protein TMEM175 keeps lysosomes running on a proton leak.Nature structural & molecular biology, , Volume: 29, Issue:7, 2022
Implications of intracellular protein degradation pathways in Parkinson's disease and therapeutics.Journal of neuroscience research, , Volume: 100, Issue:10, 2022
The emerging role of LRRK2 in tauopathies.Clinical science (London, England : 1979), , 07-15, Volume: 136, Issue:13, 2022
Molecular and functional interactions of alpha-synuclein with Rab3a.The Journal of biological chemistry, , Volume: 298, Issue:9, 2022
Role of platelet in Parkinson's disease: Insights into pathophysiology & theranostic solutions.Ageing research reviews, , Volume: 80, 2022
Could Blood Hexosylsphingosine Be a Marker for Parkinson's Disease Linked with GBA1 Mutations?Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:8, 2022
Therapeutic Insights on Ferroptosis in Parkinson's disease.European journal of pharmacology, , Sep-05, Volume: 930, 2022
A sudden collapse: the disaggregation of amyloid fibres.The EMBO journal, , 08-16, Volume: 41, Issue:16, 2022
Heparan sulfate proteoglycans mediate prion-like α-synuclein toxicity in Parkinson's in vivo models.Life science alliance, , Volume: 5, Issue:11, 2022
[Advances in Parkinson's disease induced by α-synuclein transmitted through the gut-brain axis].Sheng wu gong cheng xue bao = Chinese journal of biotechnology, , Jun-25, Volume: 38, Issue:6, 2022
[In vivo imaging of α-synuclein].Nihon yakurigaku zasshi. Folia pharmacologica Japonica, , Volume: 157, Issue:4, 2022
The role of LRRK2 in the periphery: link with Parkinson's disease and inflammatory diseases.Neurobiology of disease, , 10-01, Volume: 172, 2022
Lippia grata essential oil complexed with β-cyclodextrin ameliorates biochemical and behavioral deficits in an animal model of progressive parkinsonism.Metabolic brain disease, , Volume: 37, Issue:7, 2022
Synaptic location is a determinant of the detrimental effects of α-synuclein pathology to glutamatergic transmission in the basolateral amygdala.eLife, , 07-01, Volume: 11, 2022
p21-activated kinase 4 controls the aggregation of α-synuclein by reducing the monomeric and aggregated forms of α-synuclein: involvement of the E3 ubiquitin ligase NEDD4-1.Cell death & disease, , 06-30, Volume: 13, Issue:6, 2022
Quantum-dot-labeled synuclein seed assay identifies drugs modulating the experimental prion-like transmission.Communications biology, , 06-29, Volume: 5, Issue:1, 2022
Leveraging the preformed fibril model to distinguish between alpha-synuclein inclusion- and nigrostriatal degeneration-associated immunogenicity.Neurobiology of disease, , Volume: 171, 2022
Lysosomal functions and dysfunctions: Molecular and cellular mechanisms underlying Gaucher disease and its association with Parkinson disease.Advanced drug delivery reviews, , Volume: 187, 2022
3,4-Dihydroxyphenylethanol and 3,4-dihydroxyphenylacetic acid affect the aggregation process of E46K variant of α-synuclein at different extent: Insights into the interplay between protein dynamics and catechol effect.Protein science : a publication of the Protein Society, , Volume: 31, Issue:7, 2022
Crossroads between copper ions and amyloid formation in Parkinson's disease.Essays in biochemistry, , 12-16, Volume: 66, Issue:7, 2022
Central and Peripheral Inflammation: Connecting the Immune Responses of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
Microglia in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
Artemisia Leaf Extract protects against neuron toxicity by TRPML1 activation and promoting autophagy/mitophagy clearance in both in vitro and in vivo models of MPP+/MPTP-induced Parkinson's disease.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 104, 2022
Phosphorylated alpha-synuclein in Iba1-positive macrophages in the skin of patients with Parkinson's disease.Annals of clinical and translational neurology, , Volume: 9, Issue:8, 2022
Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization.Journal of the American Chemical Society, , 07-13, Volume: 144, Issue:27, 2022
LRRK2 and Proteostasis in Parkinson's Disease.International journal of molecular sciences, , Jun-18, Volume: 23, Issue:12, 2022
Interactions between S100A9 and Alpha-Synuclein: Insight from NMR Spectroscopy.International journal of molecular sciences, , Jun-17, Volume: 23, Issue:12, 2022
Alpha-Synuclein Autoimmune Decline in Prodromal Multiple System Atrophy and Parkinson's Disease.International journal of molecular sciences, , Jun-12, Volume: 23, Issue:12, 2022
Early Forms of Biomolecules, , 05-25, Volume: 12, Issue:6, 2022
Temporal, spatial and molecular pattern of dopaminergic neurodegeneration in the AAV-A53T α-synuclein rat model of Parkinson's disease.Behavioural brain research, , 08-26, Volume: 432, 2022
Role of post-translational modifications on the alpha-synuclein aggregation-related pathogenesis of Parkinson's disease.BMB reports, , Volume: 55, Issue:7, 2022
The Effects of Novel Formulations of Edaravone and Curcumin in the Mouse Intrastriatal Lipopolysaccharide Model of Parkinson's Disease.Frontiers in bioscience (Scholar edition), , 05-07, Volume: 14, Issue:2, 2022
Methylation of alpha-synuclein in a Sudanese cohort.Parkinsonism & related disorders, , Volume: 101, 2022
Investigating key factors underlying neurodegeneration linked to alpha-synuclein spread.Neuropathology and applied neurobiology, , Volume: 48, Issue:6, 2022
Neuroinflammation and Immune Changes in Prodromal Parkinson's Disease and Other Synucleinopathies.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
Detection of neuron-derived pathological α-synuclein in blood.Brain : a journal of neurology, , 09-14, Volume: 145, Issue:9, 2022
Restricting α-synuclein transport into mitochondria by inhibition of α-synuclein-VDAC complexation as a potential therapeutic target for Parkinson's disease treatment.Cellular and molecular life sciences : CMLS, , Jun-19, Volume: 79, Issue:7, 2022
Plasma and serum alpha-synuclein as a biomarker in Parkinson's disease: A meta-analysis.Parkinsonism & related disorders, , Volume: 99, 2022
Glutamatergic transmission and receptor expression in the synucleinopathy h-α-synL62 mouse model: Effects of hydromethylthionine.Cellular signalling, , Volume: 97, 2022
Exogenous human α-Synuclein acts in vitro as a mild platelet antiaggregant inhibiting α-thrombin-induced platelet activation.Scientific reports, , 06-14, Volume: 12, Issue:1, 2022
Role of Ubiquitin-Proteasome and Autophagy-Lysosome Pathways in α-Synuclein Aggregate Clearance.Molecular neurobiology, , Volume: 59, Issue:9, 2022
Loss of Drosophila NUS1 results in cholesterol accumulation and Parkinson's disease-related neurodegeneration.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 36, Issue:7, 2022
Automated quantification of neuronal swellings in a preclinical rodent model of Parkinson's disease detects region-specific changes in pathology.Journal of neuroscience methods, , 08-01, Volume: 378, 2022
The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability.Cell, , 06-09, Volume: 185, Issue:12, 2022
Alpha-synuclein and tau are abundantly expressed in the ENS of the human appendix and monkey cecum.PloS one, , Volume: 17, Issue:6, 2022
Pathogenic Impact of α-Synuclein Phosphorylation and Its Kinases in α-Synucleinopathies.International journal of molecular sciences, , Jun-01, Volume: 23, Issue:11, 2022
Immunogenicity of MultiTEP-Platform-Based Recombinant Protein Vaccine, PV-1950R, Targeting Three B-Cell Antigenic Determinants of Pathological α-Synuclein.International journal of molecular sciences, , May-29, Volume: 23, Issue:11, 2022
Alpha-Synuclein Aggregation Pathway in Parkinson's Disease: Current Status and Novel Therapeutic Approaches.Cells, , 05-24, Volume: 11, Issue:11, 2022
Genotypic-Phenotypic Analysis, Metabolic Profiling and Clinical Correlations in Parkinson's Disease Patients from Tamil Nadu Population, India.Journal of molecular neuroscience : MN, , Volume: 72, Issue:8, 2022
The immunology of Parkinson's disease.Seminars in immunopathology, , Volume: 44, Issue:5, 2022
Amyloids on Membrane Interfaces: Implications for Neurodegeneration.The Journal of membrane biology, , Volume: 255, Issue:6, 2022
Charge detection mass spectrometry on human-amplified fibrils from different synucleinopathies.Chemical communications (Cambridge, England), , Jun-23, Volume: 58, Issue:51, 2022
The role of Toll-like receptors and neuroinflammation in Parkinson's disease.Journal of neuroinflammation, , Jun-06, Volume: 19, Issue:1, 2022
Induced pluripotent stem cells: a tool for modeling Parkinson's disease.Trends in neurosciences, , Volume: 45, Issue:8, 2022
Can Berberine Serve as a New Therapy for Parkinson's Disease?Neurotoxicity research, , Volume: 40, Issue:4, 2022
MALAT1 lncRNA and Parkinson's Disease: The role in the Pathophysiology and Significance for Diagnostic and Therapeutic Approaches.Molecular neurobiology, , Volume: 59, Issue:9, 2022
Glycation of α-synuclein hampers its binding to synaptic-like vesicles and its driving effect on their fusion.Cellular and molecular life sciences : CMLS, , Jun-04, Volume: 79, Issue:6, 2022
Inflammatory Animal Models of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
Altered hydroxymethylome in the substantia nigra of Parkinson's disease.Human molecular genetics, , 10-10, Volume: 31, Issue:20, 2022
The relevance of synuclein autoantibodies as a biomarker for Parkinson's disease.Molecular and cellular neurosciences, , Volume: 121, 2022
Myricetin Inhibits α-Synuclein Amyloid Aggregation by Delaying the Liquid-to-Solid Phase Transition.Chembiochem : a European journal of chemical biology, , 08-17, Volume: 23, Issue:16, 2022
An analytical solution simulating growth of Lewy bodies.Mathematical medicine and biology : a journal of the IMA, , 09-08, Volume: 39, Issue:3, 2022
Exploration of the α-syn/T199678/miR-519-3p/KLF9 pathway in a PD-related α-syn pathology.Brain research bulletin, , Volume: 186, 2022
Mechanistic insights into accelerated α-synuclein aggregation mediated by human microbiome-associated functional amyloids.The Journal of biological chemistry, , Volume: 298, Issue:7, 2022
Empagliflozin alleviates endoplasmic reticulum stress and augments autophagy in rotenone-induced Parkinson's disease in rats: Targeting the GRP78/PERK/eIF2α/CHOP pathway and miR-211-5p.Chemico-biological interactions, , Aug-01, Volume: 362, 2022
Modeling Parkinson's disease-related symptoms in alpha-synuclein overexpressing mice.Brain and behavior, , Volume: 12, Issue:7, 2022
Skin alpha-synuclein deposit patterns: A predictor of Parkinson's disease subtypes.EBioMedicine, , Volume: 80, 2022
Novel insights into the role of circular RNAs in Parkinson disease: An emerging renaissance in the management of neurodegenerative diseases.Journal of neuroscience research, , Volume: 100, Issue:9, 2022
Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers.Fluids and barriers of the CNS, , May-30, Volume: 19, Issue:1, 2022
Neuroprotective Effects of Cranberry Juice Treatment in a Rat Model of Parkinson's Disease.Nutrients, , May-11, Volume: 14, Issue:10, 2022
Association between Decreased ITGA7 Levels and Increased Muscle α-Synuclein in an MPTP-Induced Mouse Model of Parkinson's Disease.International journal of molecular sciences, , May-18, Volume: 23, Issue:10, 2022
Modelling α-Synuclein Aggregation and Neurodegeneration with Fibril Seeds in Primary Cultures of Mouse Dopaminergic Neurons.Cells, , 05-13, Volume: 11, Issue:10, 2022
Extracellular Alpha-Synuclein: Mechanisms for Glial Cell Internalization and Activation.Biomolecules, , 04-30, Volume: 12, Issue:5, 2022
Comparative Analysis of the Relative Fragmentation Stabilities of Polymorphic Alpha-Synuclein Amyloid Fibrils.Biomolecules, , 04-25, Volume: 12, Issue:5, 2022
The promise of amplification assays for accurate early detection of α-synucleinopathies: A review.Experimental gerontology, , Volume: 165, 2022
Beyond neurodegenerative diseases: α-synuclein in erythropoiesis.Hematology (Amsterdam, Netherlands), , Volume: 27, Issue:1, 2022
Library-Derived Peptide Aggregation Modulators of Parkinson's Disease Early-Onset α-Synuclein Variants.ACS chemical neuroscience, , 06-15, Volume: 13, Issue:12, 2022
Altered Motor Performance, Sleep EEG, and Parkinson's Disease Pathology Induced by Chronic Sleep Deprivation in Lrrk2Neuroscience bulletin, , Volume: 38, Issue:10, 2022
Association between probable REM sleep behavior disorder and increased dermal alpha-synuclein deposition in Parkinson's disease.Parkinsonism & related disorders, , Volume: 99, 2022
A breakdown in microglial metabolic reprogramming causes internalization dysfunction of α-synuclein in a mouse model of Parkinson's disease.Journal of neuroinflammation, , May-22, Volume: 19, Issue:1, 2022
Parkinson's Disease Derived Exosomes Aggravate Neuropathology in SNCA*A53T Mice.Annals of neurology, , Volume: 92, Issue:2, 2022
Advances in Hydrogel-Based Drug Delivery Systems for Parkinson's Disease.Neurochemical research, , Volume: 47, Issue:8, 2022
Treating Parkinson's Disease via Activation of BDNF/TrkB Signaling Pathways and Inhibition of Delta-Secretase.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 19, Issue:4, 2022
Combined CSF α-SYN RT-QuIC, CSF NFL and midbrain-pons planimetry in degenerative parkinsonisms: From bedside to bench, and back again.Parkinsonism & related disorders, , Volume: 99, 2022
Loss of GBA in zebrafish leads to dopaminergic neurodegeneration, but overexpression of α-synuclein does not further worsen degeneration.Neuroreport, , 05-04, Volume: 33, Issue:7, 2022
circ-Pank1 promotes dopaminergic neuron neurodegeneration through modulating miR-7a-5p/α-syn pathway in Parkinson's disease.Cell death & disease, , 05-19, Volume: 13, Issue:5, 2022
Cholecystokinin and glucagon-like peptide-1 analogues regulate intestinal tight junction, inflammation, dopaminergic neurons and α-synuclein accumulation in the colon of two Parkinson's disease mouse models.European journal of pharmacology, , Jul-05, Volume: 926, 2022
Hybrids of polyphenolic acids and xanthone, the potential preventive and therapeutic effects on PD: Design, synthesis, in vitro anti-aggregation of α-synuclein, and disaggregation against the existed α-synuclein oligomer and fibril.Bioorganic & medicinal chemistry, , 07-15, Volume: 66, 2022
Exploring the multifactorial aspects of Gut Microbiome in Parkinson's Disease.Folia microbiologica, , Volume: 67, Issue:5, 2022
A novel high-throughput screening strategy for targeting alpha-synuclein and other long-lived proteins.SLAS discovery : advancing life sciences R & D, , Volume: 27, Issue:6, 2022
Effect of an Amyloidogenic SARS-COV-2 Protein Fragment on α-Synuclein Monomers and Fibrils.The journal of physical chemistry. B, , 05-26, Volume: 126, Issue:20, 2022
NADPH oxidase 2 activity in Parkinson's disease.Neurobiology of disease, , Volume: 170, 2022
New Insights and Implications of Natural Killer Cells in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:s1, 2022
A case series of cutaneous phosphorylated α-synuclein in Long-COVID POTS.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 32, Issue:3, 2022
Alpha-synuclein overexpression induces epigenomic dysregulation of glutamate signaling and locomotor pathways.Human molecular genetics, , 10-28, Volume: 31, Issue:21, 2022
Overlap between Central and Peripheral Transcriptomes in Parkinson's Disease but Not Alzheimer's Disease.International journal of molecular sciences, , May-06, Volume: 23, Issue:9, 2022
Pathophysiological Features of Nigral Dopaminergic Neurons in Animal Models of Parkinson's Disease.International journal of molecular sciences, , Apr-19, Volume: 23, Issue:9, 2022
Ulvan inhibits α-synuclein fibrillation and disrupts the mature fibrils: In vitro and in vivo studies.International journal of biological macromolecules, , Jun-30, Volume: 211, 2022
Detection and assessment of alpha-synuclein in Parkinson disease.Neurochemistry international, , Volume: 158, 2022
Tau accelerates α-synuclein aggregation and spreading in Parkinson's disease.Brain : a journal of neurology, , 10-21, Volume: 145, Issue:10, 2022
Lipid pathway dysfunction is prevalent in patients with Parkinson's disease.Brain : a journal of neurology, , 10-21, Volume: 145, Issue:10, 2022
Chitosan oligosaccharides exert neuroprotective effects Food & function, , May-23, Volume: 13, Issue:10, 2022
Comparative Analysis of Total Alpha-Synuclein (αSYN) Immunoassays Reveals That They Do Not Capture the Diversity of Modified αSYN Proteoforms.Journal of Parkinson's disease, , Volume: 12, Issue:5, 2022
The proSAAS Chaperone Provides Neuroprotection and Attenuates Transsynaptic α-Synuclein Spread in Rodent Models of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 12, Issue:5, 2022
Hytrin loaded polydopamine-serotonin nanohybrid induces IDH2 mediated neuroprotective effect to alleviate Parkinson's disease.Biomaterials advances, , Volume: 133, 2022
Oligomeric α-Syn and SNARE complex proteins in peripheral extracellular vesicles of neural origin are biomarkers for Parkinson's disease.Neurobiology of disease, , Volume: 148, 2021
The Role of Cholesterol in α-Synuclein and Lewy Body Pathology in GBA1 Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:5, 2021
The MHC class II transactivator modulates seeded alpha-synuclein pathology and dopaminergic neurodegeneration in an in vivo rat model of Parkinson's disease.Brain, behavior, and immunity, , Volume: 91, 2021
Immunohistochemical Detection of Synuclein Pathology in Skin in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:4, 2021
Inhibition of copper transporter 1 prevents α-synuclein pathology and alleviates nigrostriatal degeneration in AAV-based mouse model of Parkinson's disease.Redox biology, , Volume: 38, 2021
BMP5/7 protect dopaminergic neurons in an α-synuclein mouse model of Parkinson's disease.Brain : a journal of neurology, , 03-03, Volume: 144, Issue:2, 2021
Growth differentiation factor 5 exerts neuroprotection in an α-synuclein rat model of Parkinson's disease.Brain : a journal of neurology, , 03-03, Volume: 144, Issue:2, 2021
Reply: Growth differentiation factor 5 exerts neuroprotection in an α-synuclein rat model of Parkinson's disease and BMP5/7 protect dopaminergic neurons in an α-synuclein mouse model of Parkinson's disease.Brain : a journal of neurology, , 03-03, Volume: 144, Issue:2, 2021
α-synuclein abnormalities trigger focal tau pathology, spreading to various brain areas in Parkinson disease.Journal of neurochemistry, , Volume: 157, Issue:3, 2021
Activating transcription factor-4 promotes neuronal death induced by Parkinson's disease neurotoxins and α-synuclein aggregates.Cell death and differentiation, , Volume: 28, Issue:5, 2021
Epitope imprinting of alpha-synuclein for sensing in Parkinson's brain organoid culture medium.Biosensors & bioelectronics, , Mar-01, Volume: 175, 2021
Exosome-mediated delivery of antisense oligonucleotides targeting α-synuclein ameliorates the pathology in a mouse model of Parkinson's disease.Neurobiology of disease, , Volume: 148, 2021
Alpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a Parkinson's disease patient (PARK4) with SNCA triplication.FEBS open bio, , Volume: 11, Issue:2, 2021
A population scale analysis of rare SNCA variation in the UK Biobank.Neurobiology of disease, , Volume: 148, 2021
Proteomic analysis of subcellular compartments containing disseminated alpha-synuclein seeds.Neuroscience research, , Volume: 170, 2021
Genetic and Environmental Factors in Parkinson's Disease Converge on Immune Function and Inflammation.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:1, 2021
Glial activation precedes alpha-synuclein pathology in a mouse model of Parkinson's disease.Neuroscience research, , Volume: 170, 2021
Mitochondrial Dysfunction and Mitophagy in Parkinson's Disease: From Mechanism to Therapy.Trends in biochemical sciences, , Volume: 46, Issue:4, 2021
Soluble CD163 Changes Indicate Monocyte Association With Cognitive Deficits in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:4, 2021
Molecular events underlying the cell-to-cell transmission of α-synuclein.The FEBS journal, , Volume: 288, Issue:23, 2021
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Role of RhoA-ROCK signaling in Parkinson's disease.European journal of pharmacology, , Mar-05, Volume: 894, 2021
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Chitosan nanocarrier for FTY720 enhanced delivery retards Parkinson's disease via PP2A-EzH2 signaling in vitro and ex vivo.Carbohydrate polymers, , Feb-15, Volume: 254, 2021
Grafts Derived from an α-Synuclein Triplication Patient Mediate Functional Recovery but Develop Disease-Associated Pathology in the 6-OHDA Model of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 11, Issue:2, 2021
MOBP and HIP1 in multiple system atrophy: New α-synuclein partners in glial cytoplasmic inclusions implicated in the disease pathogenesis.Neuropathology and applied neurobiology, , Volume: 47, Issue:5, 2021
A rapid α-synuclein seed assay of Parkinson's disease CSF panel shows high diagnostic accuracy.Annals of clinical and translational neurology, , Volume: 8, Issue:2, 2021
Interactions of α-synuclein oligomers with lipid membranes.Biochimica et biophysica acta. Biomembranes, , 04-01, Volume: 1863, Issue:4, 2021
Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies.Journal of molecular cell biology, , 08-04, Volume: 13, Issue:4, 2021
Increased glutamate transmission onto dorsal striatum spiny projection neurons in Pink1 knockout rats.Neurobiology of disease, , Volume: 150, 2021
Is Gut Dysbiosis an Epicenter of Parkinson's Disease?Neurochemical research, , Volume: 46, Issue:3, 2021
How microcompetition with latent viruses can cause α synuclein aggregation, mitochondrial dysfunction, and eventually Parkinson's disease.Journal of neurovirology, , Volume: 27, Issue:1, 2021
14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril model.Acta neuropathologica communications, , 01-07, Volume: 9, Issue:1, 2021
Distinguishing normal and aggregated alpha-synuclein interaction on gold nanorod incorporated zinc oxide nanocomposite by electrochemical technique.International journal of biological macromolecules, , Feb-28, Volume: 171, 2021
Lipotoxicity Downstream of α-Synuclein Imbalance: A Relevant Pathomechanism in Synucleinopathies?Biomolecules, , 12-28, Volume: 12, Issue:1, 2021
Is SGSH heterozygosity a risk factor for early-onset neurodegenerative disease?Journal of inherited metabolic disease, , Volume: 44, Issue:3, 2021
Targeted graphene oxide for drug delivery as a therapeutic nanoplatform against Parkinson's disease.Biomaterials science, , Mar-10, Volume: 9, Issue:5, 2021
Targeted attenuation of elevated histone marks at SNCA alleviates α-synuclein in Parkinson's disease.EMBO molecular medicine, , 02-05, Volume: 13, Issue:2, 2021
The TCR repertoire of α-synuclein-specific T cells in Parkinson's disease is surprisingly diverse.Scientific reports, , 01-11, Volume: 11, Issue:1, 2021
Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease.Nature chemical biology, , Volume: 17, Issue:3, 2021
Intranasal administration of α-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis.Cell death & disease, , 01-13, Volume: 12, Issue:1, 2021
The Alpha-Synuclein RT-QuIC Products Generated by the Olfactory Mucosa of Patients with Parkinson's Disease and Multiple System Atrophy Induce Inflammatory Responses in SH-SY5Y Cells.Cells, , 12-28, Volume: 11, Issue:1, 2021
Molecular Tuning of the Nano-Bio Interface: Alpha-Synuclein's Surface Targeting with Doped Carbon Nanostructures.ACS applied bio materials, , 08-16, Volume: 4, Issue:8, 2021
Human α-synuclein overexpression in a mouse model of Parkinson's disease leads to vascular pathology, blood brain barrier leakage and pericyte activation.Scientific reports, , 01-13, Volume: 11, Issue:1, 2021
Therapeutic potential of hesperidin in Parkinson's disease with dementia: inhibition of alpha synuclein and amyloid beta in Drosophila melanogaster.Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, , Jun-30, Volume: 36, Issue:1, 2021
Bioinformatics Approaches for Parkinson's Disease in Clinical Practice: Data-Driven Biomarkers and Pharmacological Treatment.Advances in experimental medicine and biology, , Volume: 1338, 2021
The Parkinson's disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release.Proceedings of the National Academy of Sciences of the United States of America, , 01-05, Volume: 118, Issue:1, 2021
Development of a Protein Biochip Platform for Parkinson's Disease.Advances in experimental medicine and biology, , Volume: 1338, 2021
A SUMO1-Derived Peptide Targeting SUMO-Interacting Motif Inhibits α-Synuclein Aggregation.Cell chemical biology, , 02-18, Volume: 28, Issue:2, 2021
Seeding Propensity and Characteristics of Pathogenic αSyn Assemblies in Formalin-Fixed Human Tissue from the Enteric Nervous System, Olfactory Bulb, and Brainstem in Cases Staged for Parkinson's Disease.Cells, , 01-12, Volume: 10, Issue:1, 2021
Ellagic Acid Prevents α-Synuclein Aggregation and Protects SH-SY5Y Cells from Aggregated α-Synuclein-Induced Toxicity via Suppression of Apoptosis and Activation of Autophagy.International journal of molecular sciences, , Dec-13, Volume: 22, Issue:24, 2021
SNCA 3' UTR Genetic Variants in Patients with Parkinson's Disease.Biomolecules, , 11-30, Volume: 11, Issue:12, 2021
Cross-talks among GBA mutations, glucocerebrosidase, and α-synuclein in GBA-associated Parkinson's disease and their targeted therapeutic approaches: a comprehensive review.Translational neurodegeneration, , 01-15, Volume: 10, Issue:1, 2021
Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson's Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment.Frontiers in immunology, , Volume: 12, 2021
Expression Levels of an Alpha-Synuclein Transcript in Blood May Distinguish between Early Dementia with Lewy Bodies and Parkinson's Disease.International journal of molecular sciences, , Jan-13, Volume: 22, Issue:2, 2021
Neuropathology and molecular diagnosis of Synucleinopathies.Molecular neurodegeneration, , 12-18, Volume: 16, Issue:1, 2021
Discrimination of MSA-P and MSA-C by RT-QuIC analysis of olfactory mucosa: the first assessment of assay reproducibility between two specialized laboratories.Molecular neurodegeneration, , 12-11, Volume: 16, Issue:1, 2021
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Slow-wave sleep affects synucleinopathy and regulates proteostatic processes in mouse models of Parkinson's disease.Science translational medicine, , 12-08, Volume: 13, Issue:623, 2021
Inflammation and Parkinson's disease pathogenesis: Mechanisms and therapeutic insight.Progress in molecular biology and translational science, , Volume: 177, 2021
Updates on the Genetics of Parkinson's Disease: Clinical Implications and Future Treatment.Acta neurologica Taiwanica, , Sep-30, Volume: 30(3), 2021
Lentiviral Vectors Expressing Chimeric NEDD4 Ubiquitin Ligases: An Innovative Approach for Interfering with Alpha-Synuclein Accumulation.Cells, , 11-21, Volume: 10, Issue:11, 2021
Therapies for Genetic Forms of Parkinson's Disease: Systematic Literature Review.Journal of neuromuscular diseases, , Volume: 8, Issue:3, 2021
(De)stabilization of Alpha-Synuclein Fibrillary Aggregation by Charged and Uncharged Surfactants.International journal of molecular sciences, , Nov-19, Volume: 22, Issue:22, 2021
Protein Misfolding and Aggregation: The Relatedness between Parkinson's Disease and Hepatic Endoplasmic Reticulum Storage Disorders.International journal of molecular sciences, , Nov-18, Volume: 22, Issue:22, 2021
Polymorphism of Alpha-Synuclein Amyloid Fibrils Depends on Ionic Strength and Protein Concentration.International journal of molecular sciences, , Nov-17, Volume: 22, Issue:22, 2021
Metabotropic glutamate receptor 5 inhibits α-synuclein-induced microglia inflammation to protect from neurotoxicity in Parkinson's disease.Journal of neuroinflammation, , Jan-18, Volume: 18, Issue:1, 2021
Sgt1 Regulates α-Synuclein Subcellular Localization and Expression of Parkinson's Disease Related Genes, Biomolecules, , 11-11, Volume: 11, Issue:11, 2021
Impaired meningeal lymphatic drainage in patients with idiopathic Parkinson's disease.Nature medicine, , Volume: 27, Issue:3, 2021
α-synuclein suppresses microglial autophagy and promotes neurodegeneration in a mouse model of Parkinson's disease.Aging cell, , Volume: 20, Issue:12, 2021
Inhibition of Orexin/Hypocretin Neurons Ameliorates Elevated Physical Activity and Energy Expenditure in the A53T Mouse Model of Parkinson's Disease.International journal of molecular sciences, , Jan-14, Volume: 22, Issue:2, 2021
α-Synuclein antisense transcript SNCA-AS1 regulates synapses- and aging-related genes suggesting its implication in Parkinson's disease.Aging cell, , Volume: 20, Issue:12, 2021
Abnormal accumulation of lipid droplets in neurons induces the conversion of alpha-Synuclein to proteolytic resistant forms in a Drosophila model of Parkinson's disease.PLoS genetics, , Volume: 17, Issue:11, 2021
Clinical and molecular genetic findings of hereditary Parkinson's patients from Turkey.Parkinsonism & related disorders, , Volume: 93, 2021
Ca2+ administration prevents α-synuclein proteotoxicity by stimulating calcineurin-dependent lysosomal proteolysis.PLoS genetics, , Volume: 17, Issue:11, 2021
Design, synthesis and structure-activity evaluation of novel 2-pyridone-based inhibitors of α-synuclein aggregation with potentially improved BBB permeability.Bioorganic chemistry, , Volume: 117, 2021
Global and Regional Changes in Perivascular Space in Idiopathic and Familial Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:5, 2021
Mechanistic Insight from Preclinical Models of Parkinson's Disease Could Help Redirect Clinical Trial Efforts in GDNF Therapy.International journal of molecular sciences, , Oct-28, Volume: 22, Issue:21, 2021
The role of innate immunity and inflammation in Parkinson´s disease.Scandinavian journal of immunology, , Volume: 93, Issue:5, 2021
Chronic Exposure to Paraquat Induces Alpha-Synuclein Pathogenic Modifications in International journal of molecular sciences, , Oct-27, Volume: 22, Issue:21, 2021
The Bacterial Amyloids Phenol Soluble Modulins from International journal of molecular sciences, , Oct-27, Volume: 22, Issue:21, 2021
Effects of the Toxic Metals Arsenite and Cadmium on α-Synuclein Aggregation In Vitro and in Cells.International journal of molecular sciences, , Oct-24, Volume: 22, Issue:21, 2021
Neuropathological evidence of body-first vs. brain-first Lewy body disease.Neurobiology of disease, , Volume: 161, 2021
Gene-corrected p.A30P SNCA patient-derived isogenic neurons rescue neuronal branching and function.Scientific reports, , 11-09, Volume: 11, Issue:1, 2021
Sigma-2 receptor antagonists rescue neuronal dysfunction induced by Parkinson's patient brain-derived α-synuclein.Journal of neuroscience research, , Volume: 99, Issue:4, 2021
The Localization of Alpha-synuclein in the Endocytic Pathway.Neuroscience, , 03-01, Volume: 457, 2021
Potential of extracellular vesicles in the Parkinson's disease - Pathological mediators and biomarkers.Neurochemistry international, , Volume: 144, 2021
Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein.Acta neuropathologica communications, , 11-08, Volume: 9, Issue:1, 2021
High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson's disease.Acta neuropathologica communications, , 11-06, Volume: 9, Issue:1, 2021
ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease.Neurobiology of disease, , Volume: 161, 2021
[Neuroprotective treatment of idiopathic, genetic and atypical Parkinson's disease with alpha-synuclein-Pathology].Der Nervenarzt, , Volume: 92, Issue:12, 2021
Lipid Peroxidation Products HNE and ONE Promote and Stabilize Alpha-Synuclein Oligomers by Chemical Modifications.Biochemistry, , 11-30, Volume: 60, Issue:47, 2021
Association between CSF alpha-synuclein seeding activity and genetic status in Parkinson's disease and dementia with Lewy bodies.Acta neuropathologica communications, , 10-30, Volume: 9, Issue:1, 2021
Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity.Nature communications, , 10-29, Volume: 12, Issue:1, 2021
Potential treatment of Parkinson's disease using new-generation carbon nanotubes: a biomolecular Nanomedicine (London, England), , Volume: 16, Issue:3, 2021
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Cross-sectional associations of cerebrospinal α-synuclein, tau and amyloid-β with dyskinesias, motor fluctuations, non-motor symptoms in a cohort of Parkinson's disease patients.Journal of the neurological sciences, , Nov-15, Volume: 430, 2021
A Downsized and Optimised Intracellular Library-Derived Peptide Prevents Alpha-Synuclein Primary Nucleation and Toxicity Without Impacting Upon Lipid Binding.Journal of molecular biology, , 12-03, Volume: 433, Issue:24, 2021
Velvet Antler Methanol Extracts Ameliorate Parkinson's Disease by Inhibiting Oxidative Stress and Neuroinflammation: From Oxidative medicine and cellular longevity, , Volume: 2021, 2021
α-Synuclein evokes NLRP3 inflammasome-mediated IL-1β secretion from primary human microglia.Glia, , Volume: 69, Issue:6, 2021
[Risk and course of COVID-19 in patients with Parkinson's disease].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, , Volume: 121, Issue:9, 2021
Targeting Microglial α-Synuclein/TLRs/NF-kappaB/NLRP3 Inflammasome Axis in Parkinson's Disease.Frontiers in immunology, , Volume: 12, 2021
Unexpected Implication of SRP and AGO2 in Parkinson's Disease: Involvement in Alpha-Synuclein Biogenesis.Cells, , 10-18, Volume: 10, Issue:10, 2021
Mitochondrial Dysfunction, Protein Misfolding and Neuroinflammation in Parkinson's Disease: Roads to Biomarker Discovery.Biomolecules, , 10-13, Volume: 11, Issue:10, 2021
DJ-1 Acts as a Scavenger of α-Synuclein Oligomers and Restores Monomeric Glycated α-Synuclein.Biomolecules, , 10-06, Volume: 11, Issue:10, 2021
Single-Molecule Counting Coupled to Rapid Amplification Enables Detection of α-Synuclein Aggregates in Cerebrospinal Fluid of Parkinson's Disease Patients.Angewandte Chemie (International ed. in English), , 05-17, Volume: 60, Issue:21, 2021
Dihydroquinazolines enhance 20S proteasome activity and induce degradation of α-synuclein, an intrinsically disordered protein associated with neurodegeneration.Bioorganic & medicinal chemistry letters, , 03-15, Volume: 36, 2021
Structural and Functional Insights into α-Synuclein Fibril Polymorphism.Biomolecules, , 09-28, Volume: 11, Issue:10, 2021
Enhanced Plasmonic Biosensor Utilizing Paired Antibody and Label-Free FeBiosensors, , Oct-18, Volume: 11, Issue:10, 2021
Deficient immunoproteasome assembly drives gain of α-synuclein pathology in Parkinson's disease.Redox biology, , Volume: 47, 2021
Astrocyte dysfunction in Parkinson's disease: from the perspectives of transmitted α-synuclein and genetic modulation.Translational neurodegeneration, , 10-18, Volume: 10, Issue:1, 2021
What substance P might tell us about the prognosis and mechanism of Parkinson's disease?Neuroscience and biobehavioral reviews, , Volume: 131, 2021
The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends.Nature communications, , 10-14, Volume: 12, Issue:1, 2021
Poly (ADP-ribose) polymerase 1 and Parkinson's disease: A study in post-mortem human brain.Neurochemistry international, , Volume: 144, 2021
TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease.Neuron, , 12-01, Volume: 109, Issue:23, 2021
Peiminine Reduces ARTS-Mediated Degradation of XIAP by Modulating the PINK1/Parkin Pathway to Ameliorate 6-Hydroxydopamine Toxicity and α-Synuclein Accumulation in Parkinson's Disease Models In Vivo and In Vitro.International journal of molecular sciences, , Sep-23, Volume: 22, Issue:19, 2021
Iron as the concert master in the pathogenic orchestra playing in sporadic Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 128, Issue:10, 2021
Molecular chaperones and Parkinson's disease.Neurobiology of disease, , Volume: 160, 2021
Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption.Nature communications, , 10-08, Volume: 12, Issue:1, 2021
Discovery of styrylaniline derivatives as novel alpha-synuclein aggregates ligands.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Peripheral synucleinopathy in Parkinson disease with LRRK2 G2385R variants.Annals of clinical and translational neurology, , Volume: 8, Issue:3, 2021
Direct targeting of wild-type glucocerebrosidase by antipsychotic quetiapine improves pathogenic phenotypes in Parkinson's disease models.JCI insight, , 10-08, Volume: 6, Issue:19, 2021
Biomarkers of neurodegeneration and glial activation validated in Alzheimer's disease assessed in longitudinal cerebrospinal fluid samples of Parkinson's disease.PloS one, , Volume: 16, Issue:10, 2021
Polo-like kinase 2 inhibition reduces serine-129 phosphorylation of physiological nuclear alpha-synuclein but not of the aggregated alpha-synuclein.PloS one, , Volume: 16, Issue:10, 2021
Cationic Carbosilane Dendrimers Prevent Abnormal α-Synuclein Accumulation in Parkinson's Disease Patient-Specific Dopamine Neurons.Biomacromolecules, , 11-08, Volume: 22, Issue:11, 2021
Evaluation of Strategies for Measuring Lysosomal Glucocerebrosidase Activity.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:12, 2021
How gut microbes could drive brain disorders.Nature, , Volume: 590, Issue:7844, 2021
Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson's disease.Communications biology, , 09-29, Volume: 4, Issue:1, 2021
Membrane Remodeling and Stimulation of Aggregation Following α-Synuclein Adsorption to Phosphotidylserine Vesicles.The journal of physical chemistry. B, , 02-18, Volume: 125, Issue:6, 2021
Integration of functional genomics data to uncover cell type-specific pathways affected in Parkinson's disease.Biochemical Society transactions, , 11-01, Volume: 49, Issue:5, 2021
Is Multiple System Atrophy a Prion-like Disorder?International journal of molecular sciences, , Sep-18, Volume: 22, Issue:18, 2021
Alpha-Synuclein and the Endolysosomal System in Parkinson's Disease: Guilty by Association.Biomolecules, , 09-09, Volume: 11, Issue:9, 2021
Alpha-Synuclein and Lipids: The Elephant in the Room?Cells, , 09-17, Volume: 10, Issue:9, 2021
Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Familial Parkinson's Disease Patients Display α-Synuclein Pathology and Abnormal Mitochondrial Morphology.Cells, , 09-13, Volume: 10, Issue:9, 2021
α-Synuclein Decreases the Abundance of Proteasome Subunits and Alters Ubiquitin Conjugates in Yeast.Cells, , 08-28, Volume: 10, Issue:9, 2021
Selectivity of Lewy body protein interactions along the aggregation pathway of α-synuclein.Communications biology, , 09-23, Volume: 4, Issue:1, 2021
N-γ-(L-glutamyl)-L-selenomethionine shows neuroprotective effects against Parkinson's disease associated with SKN-1/Nrf2 and TRXR-1 in Caenorhabditis elegans.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 92, 2021
Alternative platelet activation pathways and their role in neurodegenerative diseases.Neurobiology of disease, , Volume: 159, 2021
Heterozygous GBA D409V and ATP13a2 mutations do not exacerbate pathological α-synuclein spread in the prodromal preformed fibrils model in young mice.Neurobiology of disease, , Volume: 159, 2021
Parkinson's disease outside the brain: targeting the autonomic nervous system.The Lancet. Neurology, , Volume: 20, Issue:10, 2021
The role of neuroimaging in Parkinson's disease.Journal of neurochemistry, , Volume: 159, Issue:4, 2021
The intracellular milieu of Parkinson's disease patient brain cells modulates alpha-synuclein protein aggregation.Acta neuropathologica communications, , 09-16, Volume: 9, Issue:1, 2021
Toll-like receptor 4 deficiency facilitates α-synuclein propagation and neurodegeneration in a mouse model of prodromal Parkinson's disease.Parkinsonism & related disorders, , Volume: 91, 2021
Glucocerebrosidase dysfunction in neurodegenerative disease.Essays in biochemistry, , 12-22, Volume: 65, Issue:7, 2021
Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.Chemical reviews, , 02-24, Volume: 121, Issue:4, 2021
The AKT modulator A-443654 reduces α-synuclein expression and normalizes ER stress and autophagy.The Journal of biological chemistry, , Volume: 297, Issue:4, 2021
The binding of the small heat-shock protein αB-crystallin to fibrils of α-synuclein is driven by entropic forces.Proceedings of the National Academy of Sciences of the United States of America, , 09-21, Volume: 118, Issue:38, 2021
A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy.Neurobiology of disease, , Volume: 159, 2021
Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo.Nature communications, , 09-10, Volume: 12, Issue:1, 2021
Long Non-coding RNAs in Parkinson's Disease.Neurochemical research, , Volume: 46, Issue:5, 2021
Ellagic Acid Modulates Uninduced as well as Mutation and Metal-Induced Aggregation of α-Synuclein: Implications for Parkinson's Disease.ACS chemical neuroscience, , 10-06, Volume: 12, Issue:19, 2021
Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model.Molecular neurodegeneration, , 09-09, Volume: 16, Issue:1, 2021
Novel Approaches Used to Examine and Control Neurogenesis in Parkinson's Disease.International journal of molecular sciences, , Sep-04, Volume: 22, Issue:17, 2021
Failure of Diphtheria Toxin Model to Induce Parkinson-Like Behavior in Mice.International journal of molecular sciences, , Aug-31, Volume: 22, Issue:17, 2021
[no title available]International journal of molecular sciences, , Aug-29, Volume: 22, Issue:17, 2021
The Mutation Matters: CSF Profiles of GCase, Sphingolipids, α-Synuclein in PDMovement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:5, 2021
Gut microbiota and metabolites of α-synuclein transgenic monkey models with early stage of Parkinson's disease.NPJ biofilms and microbiomes, , 09-02, Volume: 7, Issue:1, 2021
Cholesterol in Synaptic Vesicle Membranes Regulates the Vesicle-Binding, Function, and Aggregation of α-Synuclein.The journal of physical chemistry. B, , 10-14, Volume: 125, Issue:40, 2021
Swertiamarin from Enicostemma littorale, counteracts PD associated neurotoxicity via enhancement α-synuclein suppressive genes and SKN-1/NRF-2 activation through MAPK pathway.Bioorganic chemistry, , Volume: 108, 2021
α-synuclein impairs autophagosome maturation through abnormal actin stabilization.PLoS genetics, , Volume: 17, Issue:2, 2021
In vivo aggregation of presynaptic alpha-synuclein is not influenced by its phosphorylation at serine-129.Neurobiology of disease, , Volume: 152, 2021
Synthesis of Double Interfering Biodegradable Nano-MgO Micelle Composites and Their Effect on Parkinson's Disease.ACS biomaterials science & engineering, , 03-08, Volume: 7, Issue:3, 2021
REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 04-21, Volume: 41, Issue:16, 2021
Influence of Lipid Membranes on α-Synuclein Aggregation.ACS chemical neuroscience, , 03-03, Volume: 12, Issue:5, 2021
Crowded organelles, lipid accumulation, and abnormal membrane tubulation in cellular models of enhanced α-synuclein membrane interaction.Brain research, , 05-01, Volume: 1758, 2021
Interaction between Parkin and Cells, , 01-31, Volume: 10, Issue:2, 2021
α-Synuclein Heteromers in Red Blood Cells of Alzheimer's Disease and Lewy Body Dementia Patients.Journal of Alzheimer's disease : JAD, , Volume: 80, Issue:2, 2021
T Cells Limit Accumulation of Aggregate Pathology Following Intrastriatal Injection of α-Synuclein Fibrils.Journal of Parkinson's disease, , Volume: 11, Issue:2, 2021
α-Synuclein plasma membrane localization correlates with cellular phosphatidylinositol polyphosphate levels.eLife, , 02-15, Volume: 10, 2021
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture.Nature genetics, , Volume: 53, Issue:3, 2021
Investigating ELOVL7 coding variants in multiple system atrophy.Neuroscience letters, , 04-01, Volume: 749, 2021
Retina as a Model to Study In Vivo Transmission of α-Synuclein in the A53T Mouse Model of Parkinson's Disease.Methods in molecular biology (Clifton, N.J.), , Volume: 2224, 2021
Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models.Communications biology, , 02-19, Volume: 4, Issue:1, 2021
Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study.The Lancet. Neurology, , Volume: 20, Issue:3, 2021
Brazilin Removes Toxic Alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium.Journal of molecular biology, , 04-16, Volume: 433, Issue:8, 2021
A Novel SNCA A30G Mutation Causes Familial Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:7, 2021
Profiling the Biochemical Signature of GBA-Related Parkinson's Disease in Peripheral Blood Mononuclear Cells.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:5, 2021
Parkinson's Disease-Associated LRRK2 Interferes with Astrocyte-Mediated Alpha-Synuclein Clearance.Molecular neurobiology, , Volume: 58, Issue:7, 2021
Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain.Acta neuropathologica communications, , 02-25, Volume: 9, Issue:1, 2021
Ecto-GPR37: a potential biomarker for Parkinson's disease.Translational neurodegeneration, , 02-26, Volume: 10, Issue:1, 2021
Age-related increase of alpha-synuclein oligomers is associated with motor disturbances in L61 transgenic mice.Neurobiology of aging, , Volume: 101, 2021
Ghrelin protects against rotenone-induced cytotoxicity: Involvement of mitophagy and the AMPK/SIRT1/PGC1α pathway.Neuropeptides, , Volume: 87, 2021
[Therapeutic strategy for Parkinson's disease: targeting zinc-binding protein in astrocytes].Nihon yakurigaku zasshi. Folia pharmacologica Japonica, , Volume: 156, Issue:2, 2021
Investigating the relationship between the SNCA gene and cognitive abilities in idiopathic Parkinson's disease using machine learning.Scientific reports, , 03-01, Volume: 11, Issue:1, 2021
[Altered dopamine metabolism and its role in pathogenesis of Parkinson's disease].Sheng li xue bao : [Acta physiologica Sinica], , Feb-25, Volume: 73, Issue:1, 2021
Therapeutic Potential of αS Evolvability for Neuropathic Gaucher Disease.Biomolecules, , 02-15, Volume: 11, Issue:2, 2021
GBA Mutations Influence the Release and Pathological Effects of Small Extracellular Vesicles from Fibroblasts of Patients with Parkinson's Disease.International journal of molecular sciences, , Feb-23, Volume: 22, Issue:4, 2021
Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies.Cells, , 02-12, Volume: 10, Issue:2, 2021
The α-Synuclein Origin and Connectome Model (SOC Model) of Parkinson's Disease: Explaining Motor Asymmetry, Non-Motor Phenotypes, and Cognitive Decline.Journal of Parkinson's disease, , Volume: 11, Issue:2, 2021
α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson's disease.JCI insight, , 03-08, Volume: 6, Issue:5, 2021
GDNF signaling in subjects with minimal motor deficits and Parkinson's disease.Neurobiology of disease, , Volume: 153, 2021
Reduced erythrocytic CHCHD2 mRNA is associated with brain pathology of Parkinson's disease.Acta neuropathologica communications, , 03-08, Volume: 9, Issue:1, 2021
α-Synuclein-induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms.Science advances, , Volume: 7, Issue:11, 2021
CD4 T cells mediate brain inflammation and neurodegeneration in a mouse model of Parkinson's disease.Brain : a journal of neurology, , 08-17, Volume: 144, Issue:7, 2021
Alpha synuclein (SNCA) rs7684318 variant contributes to Parkinson's disease risk by altering transcription factor binding related with Notch and Wnt signaling.Neuroscience letters, , 04-17, Volume: 750, 2021
Dermal and cardiac autonomic fiber involvement in Parkinson's disease and multiple system atrophy.Neurobiology of disease, , Volume: 153, 2021
Alpha-Synuclein Handling by Microglia: Activating, Combating, and Worsening.Neuroscience bulletin, , Volume: 37, Issue:6, 2021
Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson's disease.Acta neuropathologica communications, , 03-20, Volume: 9, Issue:1, 2021
Hydration Thermodynamics of Familial Parkinson's Disease-Linked Mutants of α-Synuclein.Journal of chemical information and modeling, , 04-26, Volume: 61, Issue:4, 2021
The cell biology of Parkinson's disease.The Journal of cell biology, , 04-05, Volume: 220, Issue:4, 2021
Biosensors in Parkinson's disease.Clinica chimica acta; international journal of clinical chemistry, , Volume: 518, 2021
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells.Nature communications, , 03-22, Volume: 12, Issue:1, 2021
Progression of phosphorylated α-synuclein in Macaca fuscata.Brain pathology (Zurich, Switzerland), , Volume: 31, Issue:5, 2021
CSPα reduces aggregates and rescues striatal dopamine release in α-synuclein transgenic mice.Brain : a journal of neurology, , 07-28, Volume: 144, Issue:6, 2021
TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration.Cell reports, , 03-23, Volume: 34, Issue:12, 2021
Effects of α-Synuclein-Associated Post-Translational Modifications in Parkinson's Disease.ACS chemical neuroscience, , 04-07, Volume: 12, Issue:7, 2021
Decreased AQP4 Expression Aggravates ɑ-Synuclein Pathology in Parkinson's Disease Mice, Possibly via Impaired Glymphatic Clearance.Journal of molecular neuroscience : MN, , Volume: 71, Issue:12, 2021
Reactive microglia enhance the transmission of exosomal α-synuclein via toll-like receptor 2.Brain : a journal of neurology, , 08-17, Volume: 144, Issue:7, 2021
Antioxidant activity of calycosin against α-synuclein amyloid fibrils-induced oxidative stress in neural-like cells as a model of preventive care studies in Parkinson's disease.International journal of biological macromolecules, , Jul-01, Volume: 182, 2021
Parkinson's disease: Alterations in iron and redox biology as a key to unlock therapeutic strategies.Redox biology, , Volume: 41, 2021
PGC-1s in the Spotlight with Parkinson's Disease.International journal of molecular sciences, , Mar-28, Volume: 22, Issue:7, 2021
Reduced Interaction of Aggregated α-Synuclein and VAMP2 by Environmental Enrichment Alleviates Hyperactivity and Anxiety in a Model of Parkinson's Disease.Genes, , 03-10, Volume: 12, Issue:3, 2021
The Nigral Coup in Parkinson's Disease by α-Synuclein and Its Associated Rebels.Cells, , 03-09, Volume: 10, Issue:3, 2021
Intracerebral Administration of a Ligand-ASO Conjugate Selectively Reduces α-Synuclein Accumulation in Monoamine Neurons of Double Mutant Human A30P*A53T*α-Synuclein Transgenic Mice.International journal of molecular sciences, , Mar-13, Volume: 22, Issue:6, 2021
Could Small Heat Shock Protein HSP27 Be a First-Line Target for Preventing Protein Aggregation in Parkinson's Disease?International journal of molecular sciences, , Mar-16, Volume: 22, Issue:6, 2021
The gut-brain connection in the pathogenicity of Parkinson disease: Putative role of autophagy.Neuroscience letters, , 05-14, Volume: 753, 2021
Perampanel Inhibits α-Synuclein Transmission in Parkinson's Disease Models.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:7, 2021
Fluorescent Probe for Selective Imaging of α-Synuclein Fibrils in Living Cells.ACS chemical neuroscience, , 04-21, Volume: 12, Issue:8, 2021
Oral subchronic exposure to the mycotoxin ochratoxin A induces key pathological features of Parkinson's disease in mice six months after the end of the treatment.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, , Volume: 152, 2021
Novel therapeutic approaches for Parkinson's disease by targeting brain cholesterol homeostasis.The Journal of pharmacy and pharmacology, , Jun-08, Volume: 73, Issue:7, 2021
Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson's disease and dementia with Lewy bodies.Acta neuropathologica communications, , 04-07, Volume: 9, Issue:1, 2021
The interplay between Glucocerebrosidase, α-synuclein and lipids in human models of Parkinson's disease.Biophysical chemistry, , Volume: 273, 2021
Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia.Proceedings of the National Academy of Sciences of the United States of America, , 04-13, Volume: 118, Issue:15, 2021
In Vivo Diagnosis of Synucleinopathies: A Comparative Study of Skin Biopsy and RT-QuIC.Neurology, , 05-18, Volume: 96, Issue:20, 2021
Nanoaggregates Derived from Amyloid-beta and Alpha-synuclein Characterized by Sequential Quadruple Force Mapping.Nano letters, , 05-12, Volume: 21, Issue:9, 2021
Alpha-synuclein seeds in olfactory mucosa of patients with isolated REM sleep behaviour disorder.Brain : a journal of neurology, , 05-07, Volume: 144, Issue:4, 2021
Parkinson's disease and the gut: Models of an emerging relationship.Acta biomaterialia, , 09-15, Volume: 132, 2021
In Vivo Detection of Underlying Synucleinopathies: Are We There Yet?Neurology, , 05-18, Volume: 96, Issue:20, 2021
α-syn and SNP rs356219 as a potential biomarker in blood for Parkinson's disease in Mexican Mestizos.Neuroscience letters, , 05-29, Volume: 754, 2021
Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson's disease model.Molecular brain, , 04-19, Volume: 14, Issue:1, 2021
Increased Accumulation of α-Synuclein in Inflamed Appendices of Parkinson's Disease Patients.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:8, 2021
Ageing promotes pathological alpha-synuclein propagation and autonomic dysfunction in wild-type rats.Brain : a journal of neurology, , 07-28, Volume: 144, Issue:6, 2021
Alpha-Synuclein Oligomers and Neurofilament Light Chain Predict Phenoconversion of Pure Autonomic Failure.Annals of neurology, , Volume: 89, Issue:6, 2021
Does Human Alpha-Synuclein Behave Like Prions?CNS & neurological disorders drug targets, , Volume: 20, Issue:6, 2021
Simple, rapid and sensitive detection of Parkinson's disease related alpha-synuclein using a DNA aptamer assisted liquid crystal biosensor.Soft matter, , May-12, Volume: 17, Issue:18, 2021
Pramipexole attenuates 6-OHDA-induced Parkinson's disease by mediating the Nurr1/NF-κB pathway.Molecular biology reports, , Volume: 48, Issue:4, 2021
Curcumin: A small molecule with big functionality against amyloid aggregation in neurodegenerative diseases and type 2 diabetes.BioFactors (Oxford, England), , Volume: 47, Issue:4, 2021
A Disease Progression Model to Quantify the Nonmotor Symptoms of Parkinson's Disease in Participants With Leucine-Rich Repeat Kinase 2 Mutation.Clinical pharmacology and therapeutics, , Volume: 110, Issue:2, 2021
Consistent skin α-synuclein positivity in REM sleep behavior disorder - A two center two-to-four-year follow-up study.Parkinsonism & related disorders, , Volume: 86, 2021
Transmissible α-synuclein seeding activity in brain and stomach of patients with Parkinson's disease.Acta neuropathologica, , Volume: 141, Issue:6, 2021
Nurr1 repression mediates cardinal features of Parkinson's disease in α-synuclein transgenic mice.Human molecular genetics, , 07-28, Volume: 30, Issue:16, 2021
NMR unveils an N-terminal interaction interface on acetylated-α-synuclein monomers for recruitment to fibrils.Proceedings of the National Academy of Sciences of the United States of America, , 05-04, Volume: 118, Issue:18, 2021
Phytochemicals as Regulators of Genes Involved in Synucleinopathies.Biomolecules, , 04-22, Volume: 11, Issue:5, 2021
Changes in Drp1 Function and Mitochondrial Morphology Are Associated with the α-Synuclein Pathology in a Transgenic Mouse Model of Parkinson's Disease.Cells, , 04-13, Volume: 10, Issue:4, 2021
Genes Implicated in Familial Parkinson's Disease Provide a Dual Picture of Nigral Dopaminergic Neurodegeneration with Mitochondria Taking Center Stage.International journal of molecular sciences, , Apr-28, Volume: 22, Issue:9, 2021
The Contribution of Microglia to Neuroinflammation in Parkinson's Disease.International journal of molecular sciences, , Apr-28, Volume: 22, Issue:9, 2021
Dysfunction of RAB39B-Mediated Vesicular Trafficking in Lewy Body Diseases.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:8, 2021
Acteoside exerts neuroprotection effects in the model of Parkinson's disease via inducing autophagy: Network pharmacology and experimental study.European journal of pharmacology, , Jul-15, Volume: 903, 2021
Cerebral dopamine neurotrophic factor reduces α-synuclein aggregation and propagation and alleviates behavioral alterations in vivo.Molecular therapy : the journal of the American Society of Gene Therapy, , 09-01, Volume: 29, Issue:9, 2021
Early functional changes associated with alpha-synuclein proteinopathy in engineered human neural networks.American journal of physiology. Cell physiology, , 06-01, Volume: 320, Issue:6, 2021
α-synuclein aggregates induce c-Abl activation and dopaminergic neuronal loss by a feed-forward redox stress mechanism.Progress in neurobiology, , Volume: 202, 2021
[no title available]MMW Fortschritte der Medizin, , Volume: 163, Issue:9, 2021
Update on alpha-synuclein-based biomarker approaches in the skin, submandibular gland, gastrointestinal tract, and biofluids.Current opinion in neurology, , 08-01, Volume: 34, Issue:4, 2021
Faster disease progression in Parkinson's disease with type 2 diabetes is not associated with increased α-synuclein, tau, amyloid-β or vascular pathology.Neuropathology and applied neurobiology, , Volume: 47, Issue:7, 2021
Rationally Designed Protein-Based Inhibitor of α-Synuclein Fibrillization in Cells.Journal of medicinal chemistry, , 05-27, Volume: 64, Issue:10, 2021
Wild-type α-synuclein inherits the structure and exacerbated neuropathology of E46K mutant fibril strain by cross-seeding.Proceedings of the National Academy of Sciences of the United States of America, , 05-18, Volume: 118, Issue:20, 2021
Prodromal sensory neuropathy in Pink1Neuropathology and applied neurobiology, , Volume: 47, Issue:7, 2021
Cerebrospinal α-Synuclein Oligomers Reflect Disease Motor Severity in DeNoPa Longitudinal Cohort.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:9, 2021
Lower Plasma α-Synuclein Levels are Associated with Cognitive Impairment in Parkinson's Disease.Clinical laboratory, , May-01, Volume: 67, Issue:5, 2021
α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology.Cell reports, , 05-11, Volume: 35, Issue:6, 2021
α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson's disease from multiple system atrophy.Acta neuropathologica, , Volume: 142, Issue:3, 2021
P2X7 receptor/NLRP3 inflammasome complex and α-synuclein in peripheral blood mononuclear cells: a prospective study in neo-diagnosed, treatment-naïve Parkinson's disease.European journal of neurology, , Volume: 28, Issue:8, 2021
Skin biopSYN or how to predict Parkinson's disease.Parkinsonism & related disorders, , Volume: 86, 2021
The food additive fast green FCF inhibits α-synuclein aggregation, disassembles mature fibrils and protects against amyloid-induced neurotoxicity.Food & function, , Jun-21, Volume: 12, Issue:12, 2021
Reader Response: In Vivo Distribution of α-Synuclein in Multiple Tissues and Biofluids in Parkinson Disease.Neurology, , 05-18, Volume: 96, Issue:20, 2021
Author Response: In Vivo Distribution of α-Synuclein in Multiple Tissues and Biofluids in Parkinson Disease.Neurology, , 05-18, Volume: 96, Issue:20, 2021
α-Synuclein in Plasma-Derived Extracellular Vesicles Is a Potential Biomarker of Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:11, 2021
Hate mail: how reactive microglia spread aggregated α-synuclein.Brain : a journal of neurology, , 08-17, Volume: 144, Issue:7, 2021
[no title available]Frontiers in cellular and infection microbiology, , Volume: 11, 2021
Ellagic Acid Inhibits α-Synuclein Aggregation at Multiple Stages and Reduces Its Cytotoxicity.ACS chemical neuroscience, , 06-02, Volume: 12, Issue:11, 2021
Cerebrospinal fluid and plasma distribution of anti-α-synuclein IgMs and IgGs in multiple system atrophy and Parkinson's disease.Parkinsonism & related disorders, , Volume: 87, 2021
Linking Parkinson's Disease and Melanoma: Interplay Between α-Synuclein and Pmel17 Amyloid Formation.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:7, 2021
Phosphorylated α-synuclein and phosphorylated tau-protein in sural nerves may contribute to differentiate Parkinson's disease from multiple system atrophy and progressive supranuclear paralysis.Neuroscience letters, , 06-21, Volume: 756, 2021
Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo.Molecular neurodegeneration, , 05-24, Volume: 16, Issue:1, 2021
Development of a Sensitive Diagnostic Assay for Parkinson Disease Quantifying α-Synuclein-Containing Extracellular Vesicles.Neurology, , 05-04, Volume: 96, Issue:18, 2021
The Intersection of Parkinson's Disease, Viral Infections, and COVID-19.Molecular neurobiology, , Volume: 58, Issue:9, 2021
Cerebrospinal fluid α synuclein concentrations in patients with positive AD biomarkers and extrapyramidal symptoms.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 128, Issue:6, 2021
Lycorine, a natural alkaloid, promotes the degradation of alpha-synuclein via PKA-mediated UPS activation in transgenic Parkinson's disease models.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 87, 2021
[The role of aluminum and lead in the development of Alzheimer's and Parkinson's diseases].Arkhiv patologii, , Volume: 83, Issue:3, 2021
Transition metal dichalcogenides to optimize the performance of peptide-imprinted conductive polymers as electrochemical sensors.Mikrochimica acta, , 05-27, Volume: 188, Issue:6, 2021
Electron Microscopic Analysis of α-Synuclein Fibrils.Methods in molecular biology (Clifton, N.J.), , Volume: 2322, 2021
α-Synuclein Seeding Assay Using Cultured Cells.Methods in molecular biology (Clifton, N.J.), , Volume: 2322, 2021
Analysis of α-Synuclein in Exosomes.Methods in molecular biology (Clifton, N.J.), , Volume: 2322, 2021
Midbrain Slice Culture as an Ex Vivo Analysis Platform for Parkinson's Disease.Methods in molecular biology (Clifton, N.J.), , Volume: 2322, 2021
α-Synuclein Propagation Mouse Models of Parkinson's Disease.Methods in molecular biology (Clifton, N.J.), , Volume: 2322, 2021
Assessment of Cytotoxicity of α-Synuclein in Budding Yeast Using a Spot Growth Assay and Fluorescent Microscopy.Methods in molecular biology (Clifton, N.J.), , Volume: 2322, 2021
Movement of prion-like α-synuclein along the gut-brain axis in Parkinson's disease: A potential target of curcumin treatment.The European journal of neuroscience, , Volume: 54, Issue:2, 2021
Effects of Alpha-Synuclein Targeted Antisense Oligonucleotides on Lewy Body-Like Pathology and Behavioral Disturbances Induced by Injections of Pre-Formed Fibrils in the Mouse Motor Cortex.Journal of Parkinson's disease, , Volume: 11, Issue:3, 2021
Mesenchymal stem cell secretome protects against alpha-synuclein-induced neurodegeneration in a Caenorhabditis elegans model of Parkinson's disease.Cytotherapy, , Volume: 23, Issue:10, 2021
Complement and Coagulation Cascades are Potentially Involved in Dopaminergic Neurodegeneration in α-Synuclein-Based Mouse Models of Parkinson's Disease.Journal of proteome research, , 07-02, Volume: 20, Issue:7, 2021
Glucocerebrosidase Gene Therapy Induces Alpha-Synuclein Clearance and Neuroprotection of Midbrain Dopaminergic Neurons in Mice and Macaques.International journal of molecular sciences, , May-01, Volume: 22, Issue:9, 2021
Proteolytic α-Synuclein Cleavage in Health and Disease.International journal of molecular sciences, , May-21, Volume: 22, Issue:11, 2021
How an Infection of Sheep Revealed Prion Mechanisms in Alzheimer's Disease and Other Neurodegenerative Disorders.International journal of molecular sciences, , May-04, Volume: 22, Issue:9, 2021
Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson's Disease: The Emerging Role of VDAC.Biomolecules, , 05-11, Volume: 11, Issue:5, 2021
α-Synuclein A53T Binds to Transcriptional Adapter 2-Alpha and Blocks Histone H3 Acetylation.International journal of molecular sciences, , May-20, Volume: 22, Issue:10, 2021
Green Tea Epigallocatechin-3-gallate (EGCG) Targeting Protein Misfolding in Drug Discovery for Neurodegenerative Diseases.Biomolecules, , 05-20, Volume: 11, Issue:5, 2021
Plasma Extracellular Vesicle α-Synuclein Level in Patients with Parkinson's Disease.Biomolecules, , 05-17, Volume: 11, Issue:5, 2021
RT-QuIC Using C-Terminally Truncated α-Synuclein Forms Detects Differences in Seeding Propensity of Different Brain Regions from Synucleinopathies.Biomolecules, , 05-31, Volume: 11, Issue:6, 2021
Identification of amyloidogenic proteins in the microbiomes of a rat Parkinson's disease model and wild-type rats.Protein science : a publication of the Protein Society, , Volume: 30, Issue:9, 2021
α-Synuclein Deposition in Sympathetic Nerve Fibers in Genetic Forms of Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:10, 2021
Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates.Journal of neuroinflammation, , Jun-03, Volume: 18, Issue:1, 2021
Biomarkers for neurodegenerative diseases.Nature medicine, , Volume: 27, Issue:6, 2021
α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response.Acta neuropathologica communications, , 06-06, Volume: 9, Issue:1, 2021
The Human Hippocampus in Parkinson's Disease: An Integrative Stereological and Proteomic Study.Journal of Parkinson's disease, , Volume: 11, Issue:3, 2021
Safety and Tolerability of Active Immunotherapy Targeting α-Synuclein with PD03A in Patients with Early Parkinson's Disease: A Randomized, Placebo-Controlled, Phase 1 Study.Journal of Parkinson's disease, , Volume: 11, Issue:3, 2021
Gene Therapy to Modulate Alpha-Synuclein in Synucleinopathies.Journal of Parkinson's disease, , Volume: 11, Issue:s2, 2021
Activated microglia facilitate the transmission of α-synuclein in Parkinson's disease.Neurochemistry international, , Volume: 148, 2021
Gut and brain profiles that resemble pre-motor and early-stage Parkinson's disease in methamphetamine self-administering rats.Drug and alcohol dependence, , 08-01, Volume: 225, 2021
In Parkinson's patient-derived dopamine neurons, the triplication of α-synuclein locus induces distinctive firing pattern by impeding D2 receptor autoinhibition.Acta neuropathologica communications, , 06-07, Volume: 9, Issue:1, 2021
An attempt to dissect a peripheral marker based on cell pathology in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 128, Issue:10, 2021
Domain-Independent Inhibition of CBP/p300 Attenuates α-Synuclein Aggregation.ACS chemical neuroscience, , 07-07, Volume: 12, Issue:13, 2021
Intranasal infusion of GD3 and GM1 gangliosides downregulates alpha-synuclein and controls tyrosine hydroxylase gene in a PD model mouse.Molecular therapy : the journal of the American Society of Gene Therapy, , 10-06, Volume: 29, Issue:10, 2021
Can Plasma α-Synuclein Help Us to Differentiate Parkinson's Disease from Essential Tremor?Tremor and other hyperkinetic movements (New York, N.Y.), , 05-28, Volume: 11, 2021
The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson's disease brain as revealed by multicolor STED microscopy.Acta neuropathologica, , Volume: 142, Issue:3, 2021
From Kuru to Alzheimer: A personal outlook.Protein science : a publication of the Protein Society, , Volume: 30, Issue:9, 2021
LMK235, a small molecule inhibitor of HDAC4/5, protects dopaminergic neurons against neurotoxin- and α-synuclein-induced degeneration in cellular models of Parkinson's disease.Molecular and cellular neurosciences, , Volume: 115, 2021
Intranasal Carnosine Mitigates α-Synuclein Pathology and Motor Dysfunction in the Thy1-aSyn Mouse Model of Parkinson's Disease.ACS chemical neuroscience, , 07-07, Volume: 12, Issue:13, 2021
α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity.Nature communications, , 06-18, Volume: 12, Issue:1, 2021
Human amyloid beta and α-synuclein co-expression in neurons impair behavior and recapitulate features for Lewy body dementia in Caenorhabditis elegans.Biochimica et biophysica acta. Molecular basis of disease, , 10-01, Volume: 1867, Issue:10, 2021
α-Synuclein Responses in the Laterodorsal Tegmentum, the Pedunculopontine Tegmentum, and the Substantia Nigra: Implications for Early Appearance of Sleep Disorders in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 11, Issue:4, 2021
Comparison of Different Platform Immunoassays for the Measurement of Plasma Alpha-Synuclein in Parkinson's Disease Patients.Journal of Parkinson's disease, , Volume: 11, Issue:4, 2021
Vagus Nerve and Stomach Synucleinopathy in Parkinson's Disease, Incidental Lewy Body Disease, and Normal Elderly Subjects: Evidence Against the "Body-First" Hypothesis.Journal of Parkinson's disease, , Volume: 11, Issue:4, 2021
An Emerging Role for Phosphoinositides in the Pathophysiology of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 11, Issue:4, 2021
Phenotypic manifestation of α-synuclein strains derived from Parkinson's disease and multiple system atrophy in human dopaminergic neurons.Nature communications, , 06-21, Volume: 12, Issue:1, 2021
Physicochemical characterization of the G51D mutation of α-synuclein that is responsible for its severe cytotoxicity.Neuroscience letters, , 08-24, Volume: 760, 2021
Remodeling of the Fibrillation Pathway of α-Synuclein by Interaction with Antimicrobial Peptide LL-III.Chemistry (Weinheim an der Bergstrasse, Germany), , Aug-16, Volume: 27, Issue:46, 2021
Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 06-29, Volume: 118, Issue:26, 2021
Mini review - The role of Glucocerebrosidase and Progranulin as possible targets in the treatment of Parkinson's disease.Revue neurologique, , Volume: 177, Issue:9, 2021
C-terminal truncation of α-synuclein alters DNA structure from extension to compaction.Biochemical and biophysical research communications, , 09-03, Volume: 568, 2021
CSF Protein Level of Neurotransmitter Secretion, Synaptic Plasticity, and Autophagy in PD and DLB.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:11, 2021
Investigation of α-Synuclein Species in Plasma Exosomes and the Oligomeric and Phosphorylated α-Synuclein as Potential Peripheral Biomarker of Parkinson's Disease.Neuroscience, , 08-10, Volume: 469, 2021
[The novel mechanism of α-synuclein propagation in synucleinopathy].Nihon yakurigaku zasshi. Folia pharmacologica Japonica, , Volume: 156, Issue:4, 2021
Neuroprotective Effects of Trehalose and Sodium Butyrate on Preformed Fibrillar Form of α-Synuclein-Induced Rat Model of Parkinson's Disease.ACS chemical neuroscience, , 07-21, Volume: 12, Issue:14, 2021
Structural Features and Toxicity of α-Synuclein Oligomers Grown in the Presence of DOPAC.International journal of molecular sciences, , Jun-02, Volume: 22, Issue:11, 2021
Small Molecule Fisetin Modulates Alpha-Synuclein Aggregation.Molecules (Basel, Switzerland), , Jun-02, Volume: 26, Issue:11, 2021
Alpha-Synuclein as a Prominent Actor in the Inflammatory Synaptopathy of Parkinson's Disease.International journal of molecular sciences, , Jun-17, Volume: 22, Issue:12, 2021
Natural Alkaloid Compounds as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity.Molecules (Basel, Switzerland), , Jun-19, Volume: 26, Issue:12, 2021
Administration of AAV-Alpha Synuclein NAC Antibody Improves Locomotor Behavior in Rats Overexpressing Alpha Synuclein.Genes, , 06-21, Volume: 12, Issue:6, 2021
The Catecholaldehyde Hypothesis for the Pathogenesis of Catecholaminergic Neurodegeneration: What We Know and What We Do Not Know.International journal of molecular sciences, , Jun-01, Volume: 22, Issue:11, 2021
Recent Insights into the Interplay of Alpha-Synuclein and Sphingolipid Signaling in Parkinson's Disease.International journal of molecular sciences, , Jun-11, Volume: 22, Issue:12, 2021
Inhibition of Ceramide Synthesis Reduces α-Synuclein Proteinopathy in a Cellular Model of Parkinson's Disease.International journal of molecular sciences, , Jun-16, Volume: 22, Issue:12, 2021
Glucosylceramide Associated with Gaucher Disease Forms Amyloid-like Twisted Ribbon Fibrils That Induce α-Synuclein Aggregation.ACS nano, , Jul-27, Volume: 15, Issue:7, 2021
Common and rare variants in HFE are not associated with Parkinson's disease in Europeans.Neurobiology of aging, , Volume: 107, 2021
Preformed fibrils generated from mouse alpha-synuclein produce more inclusion pathology in rats than fibrils generated from rat alpha-synuclein.Parkinsonism & related disorders, , Volume: 89, 2021
Acupuncture for Parkinson's Disease: Efficacy Evaluation and Mechanisms in the Dopaminergic Neural Circuit.Neural plasticity, , Volume: 2021, 2021
Saffron ameliorated motor symptoms, short life span and retinal degeneration in Parkinson's disease fly models.Gene, , Oct-05, Volume: 799, 2021
Intracranial administration of alpha-synuclein fibrils in A30P-synuclein transgenic mice causes robust synucleinopathy and microglial induction.Neurobiology of aging, , Volume: 106, 2021
A new alpha-synuclein missense variant (Thr72Met) in two Turkish families with Parkinson's disease.Parkinsonism & related disorders, , Volume: 89, 2021
Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson's disease.Cell reports, , 07-06, Volume: 36, Issue:1, 2021
PIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia.Molecular psychiatry, , Volume: 26, Issue:10, 2021
miR-101-3p Contributes to Journal of healthcare engineering, , Volume: 2021, 2021
Parkinson's Disease Genetics and Pathophysiology.Annual review of neuroscience, , 07-08, Volume: 44, 2021
Macromolecular crowding modulates α-synuclein amyloid fiber growth.Biophysical journal, , 08-17, Volume: 120, Issue:16, 2021
Cutaneous α-synuclein is correlated with autonomic impairment in isolated rapid eye movement sleep behavior disorder.Sleep, , 12-10, Volume: 44, Issue:12, 2021
Electrochemical flow injection analysis of the interaction between pyrroloquinoline quinone (PQQ) and α-synuclein peptides related to Parkinson's disease.The Analyst, , Jul-21, Volume: 146, Issue:14, 2021
Effects of head trauma and sport participation in young-onset Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 128, Issue:8, 2021
Hypothalamic α-synuclein and its relation to autonomic symptoms and neuroendocrine abnormalities in Parkinson disease.Handbook of clinical neurology, , Volume: 182, 2021
Lewy bodies in the olfactory system and the hypothalamus.Handbook of clinical neurology, , Volume: 182, 2021
Trojan horses and tunneling nanotubes enable α-synuclein pathology to spread in Parkinson disease.PLoS biology, , Volume: 19, Issue:7, 2021
Temporal trajectory of biofluid markers in Parkinson's disease.Scientific reports, , 07-20, Volume: 11, Issue:1, 2021
Clustered regularly interspaced short palindromic repeats as an advanced treatment for Parkinson's disease.Brain and behavior, , Volume: 11, Issue:8, 2021
Visualization of early oligomeric α-synuclein pathology and its impact on the dopaminergic system in the (Thy-1)-h[A30P]α-syn transgenic mouse model.Journal of neuroscience research, , Volume: 99, Issue:10, 2021
Iron reduces the propagation of pathological α-synuclein: An Editorial Highlight for "Brain iron enrichment attenuates α-synuclein spreading after injection of preformed fibrils" on page 554.Journal of neurochemistry, , Volume: 159, Issue:3, 2021
Mechanistic roles for altered O-GlcNAcylation in neurodegenerative disorders.The Biochemical journal, , 07-30, Volume: 478, Issue:14, 2021
Dopamine-dependent early synaptic and motor dysfunctions induced by α-synuclein in the nigrostriatal circuit.Brain : a journal of neurology, , 12-16, Volume: 144, Issue:11, 2021
Further Characterization of Intrastriatal Lipopolysaccharide Model of Parkinson's Disease in C57BL/6 Mice.International journal of molecular sciences, , Jul-09, Volume: 22, Issue:14, 2021
Parkinson's Disease-Related Genes and Lipid Alteration.International journal of molecular sciences, , Jul-16, Volume: 22, Issue:14, 2021
Identifying the best biomarkers for α-synucleinopathies.The Lancet. Neurology, , Volume: 20, Issue:8, 2021
LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies.EMBO molecular medicine, , 09-07, Volume: 13, Issue:9, 2021
A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies.Acta neuropathologica, , Volume: 142, Issue:3, 2021
Asymmetric Dopaminergic Dysfunction in Brain-First versus Body-First Parkinson's Disease Subtypes.Journal of Parkinson's disease, , Volume: 11, Issue:4, 2021
Pursuing Multiple Biomarkers for Early Idiopathic Parkinson's Disease Diagnosis.Molecular neurobiology, , Volume: 58, Issue:11, 2021
Reelin Alleviates Mesenchymal Stem Cell Senescence and Reduces Pathological α-Synuclein Expression in an In Vitro Model of Parkinson's Disease.Genes, , 07-13, Volume: 12, Issue:7, 2021
Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson's Disease Models.Cells, , 07-05, Volume: 10, Issue:7, 2021
Parkinson's Disease: A Prionopathy?International journal of molecular sciences, , Jul-27, Volume: 22, Issue:15, 2021
Ncx3-Induced Mitochondrial Dysfunction in Midbrain Leads to Neuroinflammation in Striatum of A53t-α-Synuclein Transgenic Old Mice.International journal of molecular sciences, , Jul-30, Volume: 22, Issue:15, 2021
The Prion-Like Spreading of Alpha-Synuclein in Parkinson's Disease: Update on Models and Hypotheses.International journal of molecular sciences, , Aug-03, Volume: 22, Issue:15, 2021
Transcutaneous vagus nerve stimulation (tVNS) as a potential therapeutic application for neurodegenerative disorders - A focus on dysautonomia in Parkinson's disease.Autonomic neuroscience : basic & clinical, , Volume: 235, 2021
ATH434 Reverses Colorectal Dysfunction in the A53T Mouse Model of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 11, Issue:4, 2021
Gut brain axis: an insight into microbiota role in Parkinson's disease.Metabolic brain disease, , Volume: 36, Issue:7, 2021
The link between the gut microbiota and Parkinson's Disease: A systematic mechanism review with focus on α-synuclein transport.Brain research, , 10-15, Volume: 1769, 2021
The Neural Gut-Brain Axis of Pathological Protein Aggregation in Parkinson's Disease and Its Counterpart in Peroral Prion Infections.Viruses, , 07-18, Volume: 13, Issue:7, 2021
Upregulation of enteric alpha-synuclein as a possible link between inflammatory bowel disease and Parkinson's disease.Gut, , Volume: 70, Issue:10, 2021
Queuine, a bacterial-derived hypermodified nucleobase, shows protection in in vitro models of neurodegeneration.PloS one, , Volume: 16, Issue:8, 2021
Psychosis-Like Behavior and Hyperdopaminergic Dysregulation in Human α-Synuclein BAC Transgenic Rats.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:3, 2021
From iPS Cells to Rodents and Nonhuman Primates: Filling Gaps in Modeling Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:4, 2021
Increased telomerase improves motor function and alpha-synuclein pathology in a transgenic mouse model of Parkinson's disease associated with enhanced autophagy.Progress in neurobiology, , Volume: 199, 2021
Seven Solutions for Neuroprotection in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:2, 2021
Studying the effect of alpha-synuclein and Parkinson's disease linked mutants on inter pathway connectivities.Scientific reports, , 08-11, Volume: 11, Issue:1, 2021
From inflammasome to Parkinson's disease: Does the NLRP3 inflammasome facilitate exosome secretion and exosomal alpha-synuclein transmission in Parkinson's disease?Experimental neurology, , Volume: 336, 2021
Neuronal Bmi-1 is critical for melatonin induced ubiquitination and proteasomal degradation of α-synuclein in experimental Parkinson's disease models.Neuropharmacology, , 08-15, Volume: 194, 2021
Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient-Derived Neurons.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:3, 2021
Sulfate reducing gut bacteria and Parkinson's disease.European journal of neurology, , Volume: 28, Issue:3, 2021
Alpha Synuclein only Forms Fibrils In Vitro when Larger than its Critical Size of 70 Monomers.Chembiochem : a European journal of chemical biology, , 10-01, Volume: 22, Issue:19, 2021
Alpha-synuclein seeds of Parkinson's disease show high prion-exceeding resistance to steam sterilization.The Journal of hospital infection, , Volume: 108, 2021
Variable expression of mitochondrial complex IV in the course of nigral intracellular accumulation of α-synuclein.Parkinsonism & related disorders, , Volume: 90, 2021
Parkinson's disease risk genes act in glia to control neuronal α-synuclein toxicity.Neurobiology of disease, , Volume: 159, 2021
Treating Parkinson's Disease with Antibodies: Previous Studies and Future Directions.Journal of Parkinson's disease, , Volume: 11, Issue:1, 2021
Upregulation of Cellular Palmitoylation Mitigates α-Synuclein Accumulation and Neurotoxicity.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:2, 2021
DNAJB6 suppresses alpha-synuclein induced pathology in an animal model of Parkinson's disease.Neurobiology of disease, , Volume: 158, 2021
α-Synuclein modulates tau spreading in mouse brains.The Journal of experimental medicine, , 01-04, Volume: 218, Issue:1, 2021
Fragmentation of the Golgi complex of dopaminergic neurons in human substantia nigra: New cytopathological findings in Parkinson's disease.Histology and histopathology, , Volume: 36, Issue:1, 2021
EphA1 Activation Induces Neuropathological Changes in a Mouse Model of Parkinson's Disease Through the CXCL12/CXCR4 Signaling Pathway.Molecular neurobiology, , Volume: 58, Issue:3, 2021
Herbal Resources to Combat a Progressive & Degenerative Nervous System Disorder- Parkinson's Disease.Current drug targets, , Volume: 22, Issue:6, 2021
Alpha-synuclein pathology, microgliosis, and parvalbumin neuron loss in the amygdala associated with enhanced fear in the Thy1-aSyn model of Parkinson's disease.Neurobiology of disease, , Volume: 158, 2021
Biofluids profile of α-Klotho in patients with Parkinson's disease.Parkinsonism & related disorders, , Volume: 90, 2021
Extracellular clusterin limits the uptake of α-synuclein fibrils by murine and human astrocytes.Glia, , Volume: 69, Issue:3, 2021
Pathophysiology of Parkinson's disease: Mitochondria, alpha-synuclein and much more….Revue neurologique, , Volume: 177, Issue:3, 2021
A New Synuclein-Transgenic Mouse Model for Early Parkinson's Reveals Molecular Features of Preclinical Disease.Molecular neurobiology, , Volume: 58, Issue:2, 2021
A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α-Synuclein Mice.Annals of neurology, , Volume: 89, Issue:1, 2021
Insights into the Mechanistic Perspective Effect of Insulin on the Nonamyloidogenic Component (NAC) and α-Synuclein Aggregation.ACS chemical neuroscience, , 09-01, Volume: 12, Issue:17, 2021
Reduction of Lewy Body Pathology by Oral Cinnamon.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 16, Issue:3, 2021
Roles of α‑synuclein in gastrointestinal microbiome dysbiosis‑related Parkinson's disease progression (Review).Molecular medicine reports, , Volume: 24, Issue:4, 2021
Constitutive silencing of LRRK2 kinase activity leads to early glucocerebrosidase deregulation and late impairment of autophagy in vivo.Neurobiology of disease, , Volume: 159, 2021
Identification of new alpha-synuclein fibrillogenesis inhibitor using in silico structure-based virtual screening.Journal of molecular graphics & modelling, , Volume: 108, 2021
All-or-none amyloid disassembly via chaperone-triggered fibril unzipping favors clearance of α-synuclein toxic species.Proceedings of the National Academy of Sciences of the United States of America, , 09-07, Volume: 118, Issue:36, 2021
Toxic Feedback Loop Involving Iron, Reactive Oxygen Species, α-Synuclein and Neuromelanin in Parkinson's Disease and Intervention with Turmeric.Molecular neurobiology, , Volume: 58, Issue:11, 2021
Fatal attraction - The role of hypoxia when alpha-synuclein gets intimate with mitochondria.Neurobiology of aging, , Volume: 107, 2021
Modulating α-Synuclein Liquid-Liquid Phase Separation.Biochemistry, , 12-07, Volume: 60, Issue:48, 2021
α-Synuclein in Parkinson's Disease: Does a Prion-Like Mechanism of Propagation from Periphery to the Brain Play a Role?The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, , Volume: 27, Issue:4, 2021
Ferroptosis and its potential role in the physiopathology of Parkinson's Disease.Progress in neurobiology, , Volume: 196, 2021
Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 41, Issue:5, 2021
Peripheral inflammation exacerbates α-synuclein toxicity and neuropathology in Parkinson's models.Neuropathology and applied neurobiology, , Volume: 47, Issue:1, 2021
Monitoring of a progressive functional dopaminergic deficit in the A53T-AAV synuclein rats by combining 6-[Neurobiology of aging, , Volume: 107, 2021
Synuclein Family Members Prevent Membrane Damage by Counteracting α-Synuclein Aggregation.Biomolecules, , 07-21, Volume: 11, Issue:8, 2021
STochastic Optical Reconstruction Microscopy (STORM) reveals the nanoscale organization of pathological aggregates in human brain.Neuropathology and applied neurobiology, , Volume: 47, Issue:1, 2021
Roles for α-Synuclein in Gene Expression.Genes, , 07-29, Volume: 12, Issue:8, 2021
[Non-motor symptoms of Parkinson's disease from pathophysiology to early diagnosis].La Revue de medecine interne, , Volume: 42, Issue:4, 2021
Neurorescue Effects of Frondoside A and Ginsenoside Rg3 in Molecules (Basel, Switzerland), , Aug-10, Volume: 26, Issue:16, 2021
Epigenetic inactivation of the autophagy-lysosomal system in appendix in Parkinson's disease.Nature communications, , 08-26, Volume: 12, Issue:1, 2021
Glucocerebrosidase mutations: A paradigm for neurodegeneration pathways.Free radical biology & medicine, , 11-01, Volume: 175, 2021
Pharmacological inhibition and knockdown of O-GlcNAcase reduces cellular internalization of α-synuclein preformed fibrils.The FEBS journal, , Volume: 288, Issue:2, 2021
Ten Unsolved Questions About Neuroinflammation in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:1, 2021
Astaxanthin suppresses endoplasmic reticulum stress and protects against neuron damage in Parkinson's disease by regulating miR-7/SNCA axis.Neuroscience research, , Volume: 165, 2021
Diagnostic utility of fluid biomarkers in multiple system atrophy: a systematic review and meta-analysis.Journal of neurology, , Volume: 268, Issue:8, 2021
C/EBPβ/δ-secretase signaling mediates Parkinson's disease pathogenesis via regulating transcription and proteolytic cleavage of α-synuclein and MAOB.Molecular psychiatry, , Volume: 26, Issue:2, 2021
Update on the association between alpha-synuclein and tau with mitochondrial dysfunction: Implications for Parkinson's disease.The European journal of neuroscience, , Volume: 53, Issue:9, 2021
Neuroprotective effect of metformin on dopaminergic neurodegeneration and α-synuclein aggregation in C. elegans model of Parkinson's disease.Neuroscience research, , Volume: 162, 2021
Systemic α-synuclein injection triggers selective neuronal pathology as seen in patients with Parkinson's disease.Molecular psychiatry, , Volume: 26, Issue:2, 2021
Potentials of autophagy enhancing natural products in the treatment of Parkinson disease.Drug metabolism and personalized therapy, , 08-13, Volume: 37, Issue:2, 2021
Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease.Acta neuropathologica communications, , 11-19, Volume: 8, Issue:1, 2020
CMT-3 targets different α-synuclein aggregates mitigating their toxic and inflammogenic effects.Scientific reports, , 11-20, Volume: 10, Issue:1, 2020
Preferential microglial activation associated with pathological alpha synuclein transmission.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, , Volume: 81, 2020
Ractopamine residue in meat might protect people from Parkinson disease.Medical hypotheses, , Volume: 145, 2020
MRI-visible perivascular spaces are associated with cerebrospinal fluid biomarkers in Parkinson's disease.Aging, , 11-25, Volume: 12, Issue:24, 2020
Plasma Total α-Synuclein and Neurofilament Light Chain: Clinical Validation for Discriminating Parkinson's Disease from Normal Control.Dementia and geriatric cognitive disorders, , Volume: 49, Issue:4, 2020
Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war.Nature communications, , 11-27, Volume: 11, Issue:1, 2020
Effect of Ionic Strength on Thioflavin-T Affinity to Amyloid Fibrils and Its Fluorescence Intensity.International journal of molecular sciences, , Nov-24, Volume: 21, Issue:23, 2020
Novel antibodies detect additional α-synuclein pathology in synucleinopathies: potential development for immunotherapy.Alzheimer's research & therapy, , 11-30, Volume: 12, Issue:1, 2020
Parkinson's disease and translational research.Translational neurodegeneration, , 12-01, Volume: 9, Issue:1, 2020
Identification and Evaluation of Bisquinoline Scaffold as a New Candidate for α-Synuclein-PET Imaging.ACS chemical neuroscience, , 12-16, Volume: 11, Issue:24, 2020
Pathological Functions of LRRK2 in Parkinson's Disease.Cells, , 11-30, Volume: 9, Issue:12, 2020
Enteric Glia at the Crossroads between Intestinal Immune System and Epithelial Barrier: Implications for Parkinson Disease.International journal of molecular sciences, , Dec-02, Volume: 21, Issue:23, 2020
Neuron-Astrocyte Interactions in Parkinson's Disease.Cells, , 12-07, Volume: 9, Issue:12, 2020
Isotope-reinforced polyunsaturated fatty acids improve Parkinson's disease-like phenotype in rats overexpressing α-synuclein.Acta neuropathologica communications, , 12-11, Volume: 8, Issue:1, 2020
Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing α-synuclein and immune activation of Parkinson's disease.Science advances, , Volume: 6, Issue:50, 2020
Validation and assessment of preanalytical factors of a fluorometric in vitro assay for glucocerebrosidase activity in human cerebrospinal fluid.Scientific reports, , 12-16, Volume: 10, Issue:1, 2020
The value of cerebrospinal fluid α-synuclein and the tau/α-synuclein ratio for diagnosis of neurodegenerative disorders with Lewy pathology.European journal of neurology, , Volume: 27, Issue:1, 2020
Evaluating the Effects of Grain of Isogenic Wheat Lines Differing in the Content of Anthocyanins in Mouse Models of Neurodegenerative Disorders.Nutrients, , Dec-18, Volume: 12, Issue:12, 2020
Iron Dysregulation and Inflammagens Related to Oral and Gut Health Are Central to the Development of Parkinson's Disease.Biomolecules, , 12-29, Volume: 11, Issue:1, 2020
Fibrillar α-synuclein toxicity depends on functional lysosomes.The Journal of biological chemistry, , 12-18, Volume: 295, Issue:51, 2020
Alpha-Synuclein: The Interplay of Pathology, Neuroinflammation, and Environmental Factors in Parkinson's Disease.Neuro-degenerative diseases, , Volume: 20, Issue:2-3, 2020
A sticky situation: Aberrant protein-protein interactions in Parkinson's disease.Seminars in cell & developmental biology, , Volume: 99, 2020
Small vessel disease pathological changes in neurodegenerative and vascular dementias concomitant with autonomic dysfunction.Brain pathology (Zurich, Switzerland), , Volume: 30, Issue:1, 2020
Parkinson's disease and the gastrointestinal microbiome.Journal of neurology, , Volume: 267, Issue:9, 2020
Alpha-Synuclein in the Gastrointestinal Tract as a Potential Biomarker for Early Detection of Parkinson's Disease.International journal of molecular sciences, , Nov-17, Volume: 21, Issue:22, 2020
The Role of α-Synuclein Oligomers in Parkinson's Disease.International journal of molecular sciences, , Nov-17, Volume: 21, Issue:22, 2020
Megadalton-sized Dityrosine Aggregates of α-Synuclein Retain High Degrees of Structural Disorder and Internal Dynamics.Journal of molecular biology, , 12-04, Volume: 432, Issue:24, 2020
Effects of Grape Polyphenols on the Life Span and Neuroinflammatory Alterations Related to Neurodegenerative Parkinson Disease-Like Disturbances in Mice.Molecules (Basel, Switzerland), , Nov-16, Volume: 25, Issue:22, 2020
Complex Interaction between Resident Microbiota and Misfolded Proteins: Role in Neuroinflammation and Neurodegeneration.Cells, , 11-13, Volume: 9, Issue:11, 2020
Modeling Parkinson's Disease Neuropathology and Symptoms by Intranigral Inoculation of Preformed Human α-Synuclein Oligomers.International journal of molecular sciences, , Nov-12, Volume: 21, Issue:22, 2020
Gut Microbiota Approach-A New Strategy to Treat Parkinson's Disease.Frontiers in cellular and infection microbiology, , Volume: 10, 2020
The Library Derived 4554W Peptide Inhibits Primary Nucleation of α-Synuclein.Journal of molecular biology, , 12-04, Volume: 432, Issue:24, 2020
Epigallocatechin Gallate Destabilizes α-Synuclein Fibril by Disrupting the E46-K80 Salt-Bridge and Inter-protofibril Interface.ACS chemical neuroscience, , 12-16, Volume: 11, Issue:24, 2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disease.International journal of molecular sciences, , Nov-10, Volume: 21, Issue:22, 2020
Molecular dissection of amyloid disaggregation by human HSP70.Nature, , Volume: 587, Issue:7834, 2020
Amyloid-like oligomerization of AIMP2 contributes to α-synuclein interaction and Lewy-like inclusion.Science translational medicine, , 11-11, Volume: 12, Issue:569, 2020
Determinants of seeding and spreading of α-synuclein pathology in the brain.Science advances, , Volume: 6, Issue:46, 2020
Pathological findings in a patient with alpha-synuclein p.A53T and familial Parkinson's disease.Parkinsonism & related disorders, , Volume: 81, 2020
Negative α-synuclein pathology in the submandibular gland of patients carrying PRKN pathogenic variants.Parkinsonism & related disorders, , Volume: 81, 2020
Prolyl oligopeptidase inhibition by KYP-2407 increases alpha-synuclein fibril degradation in neuron-like cells.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 131, 2020
The Emerging Role of the Lysosome in Parkinson's Disease.Cells, , 11-02, Volume: 9, Issue:11, 2020
Unraveling the NaCl Concentration Effect on the First Stages of α-Synuclein Aggregation.Biomacromolecules, , 12-14, Volume: 21, Issue:12, 2020
Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy.Cells, , 10-29, Volume: 9, Issue:11, 2020
Parkinson's disease is an autoimmune disease: A reappraisal.Autoimmunity reviews, , Volume: 19, Issue:12, 2020
Multiplicity of α-Synuclein Aggregated Species and Their Possible Roles in Disease.International journal of molecular sciences, , Oct-28, Volume: 21, Issue:21, 2020
Apitherapy for Parkinson's Disease: A Focus on the Effects of Propolis and Royal Jelly.Oxidative medicine and cellular longevity, , Volume: 2020, 2020
Korean Red Ginseng Regulates Intestinal Tight Junction and Inflammation in the Colon of a Parkinson's Disease Mouse Model.Journal of medicinal food, , Volume: 23, Issue:12, 2020
Impaired metabolic brain networks associated with neurotransmission systems in the α-synuclein spectrum.Parkinsonism & related disorders, , Volume: 81, 2020
CD8 T cell nigral infiltration precedes synucleinopathy in early stages of Parkinson's disease.Brain : a journal of neurology, , 12-01, Volume: 143, Issue:12, 2020
Fast kinetics of environmentally induced α-synuclein aggregation mediated by structural alteration in NAC region and result in structure dependent cytotoxicity.Scientific reports, , 10-27, Volume: 10, Issue:1, 2020
Alpha-Synuclein in Alcohol Use Disorder, Connections with Parkinson's Disease and Potential Therapeutic Role of 5' Untranslated Region-Directed Small Molecules.Biomolecules, , 10-21, Volume: 10, Issue:10, 2020
Stress-induced p53 drives BAG5 cochaperone expression to control α-synuclein aggregation in Parkinson's disease.Aging, , 10-21, Volume: 12, Issue:20, 2020
[no title available]Aging, , 10-20, Volume: 12, Issue:20, 2020
Valeric Acid Protects Dopaminergic Neurons by Suppressing Oxidative Stress, Neuroinflammation and Modulating Autophagy Pathways.International journal of molecular sciences, , Oct-16, Volume: 21, Issue:20, 2020
Rapid Structural, Kinetic, and Immunochemical Analysis of Alpha-Synuclein Oligomers in Solution.Nano letters, , 11-11, Volume: 20, Issue:11, 2020
Cell type-specific lipid storage changes in Parkinson's disease patient brains are recapitulated by experimental glycolipid disturbance.Proceedings of the National Academy of Sciences of the United States of America, , 11-03, Volume: 117, Issue:44, 2020
Developmental deficits and early signs of neurodegeneration revealed by PD patient derived dopamine neurons.Stem cell research, , Volume: 49, 2020
Comparison of 123I-MIBG scintigraphy and phosphorylated α-synuclein skin deposits in synucleinopathies.Parkinsonism & related disorders, , Volume: 81, 2020
Modulation of α-Synuclein Fibrillation by Ultrasmall and Biocompatible Gold Nanoclusters.ACS chemical neuroscience, , 10-21, Volume: 11, Issue:20, 2020
Orthostatic hypotension as a core symptom in a Japanese family harboring SNCA duplication.Parkinsonism & related disorders, , Volume: 81, 2020
Endosomal dysfunction in iPSC-derived neural cells from Parkinson's disease patients with VPS35 D620N.Molecular brain, , 10-08, Volume: 13, Issue:1, 2020
Misfolded protein propagation in an integrated computational model of structural network and LRRK2 gene expression.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, , Volume: 2020, 2020
Alpha-Synuclein Protofibrils in Cerebrospinal Fluid: A Potential Biomarker for Parkinson's Disease.Journal of Parkinson's disease, , Volume: 10, Issue:4, 2020
Microglia modulate neurodegeneration in Alzheimer's and Parkinson's diseases.Science (New York, N.Y.), , 10-02, Volume: 370, Issue:6512, 2020
The Down-Regulation of Clusterin Expression Enhances the αSynuclein Aggregation Process.International journal of molecular sciences, , Sep-29, Volume: 21, Issue:19, 2020
Tau knockout exacerbates degeneration of parvalbumin-positive neurons in substantia nigra pars reticulata in Parkinson's disease-related α-synuclein A53T mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 34, Issue:9, 2020
Toxic Metamorphosis-How Changes from Lysosomal to Cytosolic pH Modify the Alpha-Synuclein Aggregation Pattern.Biomacromolecules, , 12-14, Volume: 21, Issue:12, 2020
CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease.Nature communications, , 09-28, Volume: 11, Issue:1, 2020
Graphene-Based Nanoparticles as Potential Treatment Options for Parkinson's Disease: A Molecular Dynamics Study.International journal of nanomedicine, , Volume: 15, 2020
Pathogenic LRRK2 requires secondary factors to induce cellular toxicity.Bioscience reports, , 10-30, Volume: 40, Issue:10, 2020
The role of natural killer cells in Parkinson's disease.Experimental & molecular medicine, , Volume: 52, Issue:9, 2020
No enhanced (p-) α-synuclein deposition in gastrointestinal tissue of Parkinson's disease patients.Parkinsonism & related disorders, , Volume: 80, 2020
How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structNeurobiology of disease, , Volume: 146, 2020
Diphenyl triazine hybrids inhibit α-synuclein fibrillogenesis: Design, synthesis and in vitro efficacy studies.European journal of medicinal chemistry, , Dec-01, Volume: 207, 2020
Blinded RT-QuIC Analysis of α-Synuclein Biomarker in Skin Tissue From Parkinson's Disease Patients.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:12, 2020
The mechanistic role of alpha-synuclein in the nucleus: impaired nuclear function caused by familial Parkinson's disease SNCA mutations.Human molecular genetics, , 11-04, Volume: 29, Issue:18, 2020
Associations of sleep characteristics with alpha-synuclein in cerebrospinal fluid in older adults.Annals of clinical and translational neurology, , Volume: 7, Issue:10, 2020
Facile Impedimetric Analysis of Neuronal Exosome Markers in Parkinson's Disease Diagnostics.Analytical chemistry, , 10-20, Volume: 92, Issue:20, 2020
Metabolomics Fingerprint Induced by the Intranigral Inoculation of Exogenous Human Alpha-Synuclein Oligomers in a Rat Model of Parkinson's Disease.International journal of molecular sciences, , Sep-14, Volume: 21, Issue:18, 2020
Authors' replies to the comments of Koga et al. on "Movement disorders rounds: A case of missing pathology in a patient with LRRK2 Parkinson's disease".Parkinsonism & related disorders, , Volume: 79, 2020
Using High-Content Screening to Generate Single-Cell Gene-Corrected Patient-Derived iPS Clones Reveals Excess Alpha-Synuclein with Familial Parkinson's Disease Point Mutation A30P.Cells, , 09-10, Volume: 9, Issue:9, 2020
Squalamine Restores the Function of the Enteric Nervous System in Mouse Models of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 10, Issue:4, 2020
Rational design of small molecules able to inhibit α-synuclein amyloid aggregation for the treatment of Parkinson's disease.Journal of enzyme inhibition and medicinal chemistry, , Volume: 35, Issue:1, 2020
Phosphorylated Alpha-Synuclein Within Cutaneous Autonomic Nerves of Patients With Parkinson's Disease: The Implications of Sample Thickness on Results.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, , Volume: 68, Issue:10, 2020
Astrocytes in Parkinson's disease: from preclinical assays to in vivo imaging and therapeutic probes.Neurobiology of aging, , Volume: 95, 2020
Immunoproteasome is up-regulated in rotenone-induced Parkinson's disease rat model.Neuroscience letters, , 11-01, Volume: 738, 2020
Hippocampal subfield pathologic burden in Lewy body diseases vs. Alzheimer's disease.Neuropathology and applied neurobiology, , Volume: 46, Issue:7, 2020
A Phase 1 Randomized Trial of Specific Active α-Synuclein Immunotherapies PD01A and PD03A in Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:11, 2020
Metabolic alterations in Parkinson's disease astrocytes.Scientific reports, , 09-02, Volume: 10, Issue:1, 2020
Alpha-synuclein aggresomes inhibit ciliogenesis and multiple functions of the centrosome.Biology open, , 10-05, Volume: 9, Issue:10, 2020
Naphthoquinone-Dopamine Hybrids Inhibit α-Synuclein Aggregation, Disrupt Preformed Fibrils, and Attenuate Aggregate-Induced Toxicity.Chemistry (Weinheim an der Bergstrasse, Germany), , Dec-09, Volume: 26, Issue:69, 2020
Transgenic Mice Expressing Human α-Synuclein in Noradrenergic Neurons Develop Locus Ceruleus Pathology and Nonmotor Features of Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 09-23, Volume: 40, Issue:39, 2020
Defining an amyloid link Between Parkinson's disease and melanoma.Proceedings of the National Academy of Sciences of the United States of America, , 09-15, Volume: 117, Issue:37, 2020
Mangosteen Pericarp and Its Bioactive Xanthones: Potential Therapeutic Value in Alzheimer's Disease, Parkinson's Disease, and Depression with Pharmacokinetic and Safety Profiles.International journal of molecular sciences, , Aug-27, Volume: 21, Issue:17, 2020
Blood Flow as a Route for Bidirectional Propagation of Synucleinopathy in Parkinson's Disease?Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:10, 2020
Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons.Journal of visualized experiments : JoVE, , 08-16, Issue:162, 2020
Conjugal multiple system atrophy: Rethinking numbers of probability.Parkinsonism & related disorders, , Volume: 77, 2020
Effect of Disease-Associated P123H and V70M Mutations on β-Synuclein Fibrillation.ACS chemical neuroscience, , 09-16, Volume: 11, Issue:18, 2020
Brain-first versus body-first Parkinson's disease: a multimodal imaging case-control study.Brain : a journal of neurology, , 10-01, Volume: 143, Issue:10, 2020
Differential activity of glucocerebrosidase in neurons and astrocytes; implications for evaluating tissue homogenates derived from Parkinson's disease brains.Journal of the neurological sciences, , 11-15, Volume: 418, 2020
COVID-19 and selective vulnerability to Parkinson's disease.The Lancet. Neurology, , Volume: 19, Issue:9, 2020
Gut Microbiome Imbalance and Neuroinflammation: Impact of COVID-19 on Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:9, 2020
Cathepsin K is a potent disaggregase of α-synuclein fibrils.Biochemical and biophysical research communications, , 09-03, Volume: 529, Issue:4, 2020
Cofilin 1 promotes the aggregation and cell-to-cell transmission of α-synuclein in Parkinson's disease.Biochemical and biophysical research communications, , 09-03, Volume: 529, Issue:4, 2020
Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys.EBioMedicine, , Volume: 59, 2020
LRRK2 kinase inhibitors reduce alpha-synuclein in human neuronal cell lines with the G2019S mutation.Neurobiology of disease, , Volume: 144, 2020
T cell infiltration and upregulation of MHCII in microglia leads to accelerated neuronal loss in an α-synuclein rat model of Parkinson's disease.Journal of neuroinflammation, , Aug-15, Volume: 17, Issue:1, 2020
Generation of two iPS cell lines (HIHDNDi001-A and HIHDNDi001-B) from a Parkinson's disease patient carrying the heterozygous p.A30P mutation in SNCA.Stem cell research, , Volume: 48, 2020
Effect of kaempferol on the transgenic Drosophila model of Parkinson's disease.Scientific reports, , 08-14, Volume: 10, Issue:1, 2020
The effect of copy number on α-synuclein's toxicity and its protective role in Bax-induced apoptosis, in yeast.Bioscience reports, , 09-30, Volume: 40, Issue:9, 2020
Polypeptides derived from α-Synuclein binding partners to prevent α-Synuclein fibrils interaction with and take-up by cells.PloS one, , Volume: 15, Issue:8, 2020
Neuroprotection of Rotenone-Induced Parkinsonism by Ursolic Acid in PD Mouse Model.CNS & neurological disorders drug targets, , Volume: 19, Issue:7, 2020
Real-Time Characterization of Cell Membrane Disruption by α-Synuclein Oligomers in Live SH-SY5Y Neuroblastoma Cells.ACS chemical neuroscience, , 09-02, Volume: 11, Issue:17, 2020
Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding.ACS chemical biology, , 08-21, Volume: 15, Issue:8, 2020
Discoidin Domain Receptor 1 is a therapeutic target for neurodegenerative diseases.Human molecular genetics, , 10-10, Volume: 29, Issue:17, 2020
Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity.Acta neuropathologica communications, , 08-06, Volume: 8, Issue:1, 2020
Therapeutic innovation in Parkinson's disease: a 2020 update on disease-modifying approaches.Expert review of neurotherapeutics, , Volume: 20, Issue:10, 2020
Iron promotes the clearance of α-synuclein: An Editorial for 'H63D variant of the homeostatic iron regulator (HFE) gene alters α-synuclein expression, aggregation, and toxicity" on page 177.Journal of neurochemistry, , Volume: 155, Issue:2, 2020
Where and how alpha-synuclein pathology spreads in Parkinson's disease.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 40, Issue:5, 2020
In vivo distribution of α-synuclein in multiple tissues and biofluids in Parkinson disease.Neurology, , 09-01, Volume: 95, Issue:9, 2020
Parkinson's disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EM.Proceedings of the National Academy of Sciences of the United States of America, , 08-18, Volume: 117, Issue:33, 2020
Alleviating toxic α-Synuclein accumulation by membrane depolarization: evidence from an in vitro model of Parkinson's disease.Molecular brain, , 07-31, Volume: 13, Issue:1, 2020
Microglia and astrocyte dysfunction in parkinson's disease.Neurobiology of disease, , Volume: 144, 2020
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.Scientific reports, , 07-30, Volume: 10, Issue:1, 2020
Somatic mutations in neurodegeneration: An update.Neurobiology of disease, , Volume: 144, 2020
Role of Tyr-39 for the Structural Features of α-Synuclein and for the Interaction with a Strong Modulator of Its Amyloid Assembly.International journal of molecular sciences, , Jul-17, Volume: 21, Issue:14, 2020
Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor.International journal of molecular sciences, , Jul-22, Volume: 21, Issue:15, 2020
Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression.Aging, , 07-24, Volume: 12, Issue:14, 2020
The hot sites of α-synuclein in amyloid fibril formation.Scientific reports, , 07-22, Volume: 10, Issue:1, 2020
Systemic Synuclein Sampling Study toward a Parkinson disease biomarker: Final results?Neurology, , 09-01, Volume: 95, Issue:9, 2020
α-Synuclein aggregation and transmission in Parkinson's disease: a link to mitochondria and lysosome.Science China. Life sciences, , Volume: 63, Issue:12, 2020
Classification of α-synuclein-induced changes in the AAV α-synuclein rat model of Parkinson's disease using electrophysiological measurements of visual processing.Scientific reports, , 07-17, Volume: 10, Issue:1, 2020
Prolongation of metallothionein induction combats Aß and α-synuclein toxicity in aged transgenic Caenorhabditis elegans.Scientific reports, , 07-16, Volume: 10, Issue:1, 2020
Evaluating the Role of SNCA, LRRK2, and GBA in Chinese Patients With Early-Onset Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:11, 2020
Lysosomal Storage Disorders Shed Light on Lysosomal Dysfunction in Parkinson's Disease.International journal of molecular sciences, , Jul-14, Volume: 21, Issue:14, 2020
Interaction of Alpha-Synuclein and Its Mutants with Rigid Lipid Vesicle Mimics of Varying Surface Curvature.ACS nano, , 08-25, Volume: 14, Issue:8, 2020
Autophagy and Parkinson's Disease.Advances in experimental medicine and biology, , Volume: 1207, 2020
Genetic Variation in Complex Traits in Transgenic α-Synuclein Strains of Genes, , 07-11, Volume: 11, Issue:7, 2020
SNPs in SNCA, MCCC1, DLG2, GBF1 and MBNL2 are associated with Parkinson's disease in southern Chinese population.Journal of cellular and molecular medicine, , Volume: 24, Issue:15, 2020
In silico drug repositioning of FDA-approved drugs to predict new inhibitors for alpha-synuclein aggregation.Computational biology and chemistry, , Volume: 88, 2020
Nano-imaging trace elements at organelle levels in substantia nigra overexpressing α-synuclein to model Parkinson's disease.Communications biology, , 07-09, Volume: 3, Issue:1, 2020
[Relationship between Drug Metabolism and Intestinal Microbiota in Parkinson's Disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:7, 2020
Erythrocytic α-synuclein contained in microvesicles regulates astrocytic glutamate homeostasis: a new perspective on Parkinson's disease pathogenesis.Acta neuropathologica communications, , 07-08, Volume: 8, Issue:1, 2020
Characterization of a pathogenic variant in GBA for Parkinson's disease with mild cognitive impairment patients.Molecular brain, , 07-08, Volume: 13, Issue:1, 2020
Caffeine: An Overview of Its Beneficial Effects in Experimental Models and Clinical Trials of Parkinson's Disease.International journal of molecular sciences, , Jul-04, Volume: 21, Issue:13, 2020
Copper and iron ions accelerate the prion-like propagation of α-synuclein: A vicious cycle in Parkinson's disease.International journal of biological macromolecules, , Nov-15, Volume: 163, 2020
Parkinson's disease a futile entangle of Mankind's credence on an herbal remedy: A review.Life sciences, , Sep-15, Volume: 257, 2020
Understanding the Pathogenesis Involved in Parkinson's Disease and Potential Therapeutic Treatment Strategies.Central nervous system agents in medicinal chemistry, , Volume: 20, Issue:2, 2020
Phase II Dose Selection for Alpha Synuclein-Targeting Antibody Cinpanemab (BIIB054) Based on Target Protein Binding Levels in the Brain.CPT: pharmacometrics & systems pharmacology, , Volume: 9, Issue:9, 2020
Enhancing the Activity of Glucocerebrosidase as a Treatment for Parkinson Disease.CNS drugs, , Volume: 34, Issue:9, 2020
Small-molecule inhibitors of α-synuclein for the treatment of Parkinson's disease: a patent landscape.Pharmaceutical patent analyst, , Volume: 9, Issue:3, 2020
Eye lens crystallin proteins inhibit the autocatalytic amyloid amplification nature of mature α-synuclein fibrils.PloS one, , Volume: 15, Issue:6, 2020
Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease.The Journal of clinical investigation, , 08-03, Volume: 130, Issue:8, 2020
Structural brain changes in Ser129-phosphorylated alpha-synuclein rats based on voxel-based morphometry.Behavioural brain research, , 09-01, Volume: 393, 2020
General Aggregation-Induced Emission Probes for Amyloid Inhibitors with Dual Inhibition Capacity against Amyloid β-Protein and α-Synuclein.ACS applied materials & interfaces, , Jul-15, Volume: 12, Issue:28, 2020
Dual Targeting of Monomeric Tau and α-Synuclein Aggregation: A New Multitarget Therapeutic Strategy for Neurodegeneration.ACS chemical neuroscience, , 07-15, Volume: 11, Issue:14, 2020
Fasudil Promotes α-Synuclein Clearance in an AAV-Mediated α-Synuclein Rat Model of Parkinson's Disease by Autophagy Activation.Journal of Parkinson's disease, , Volume: 10, Issue:3, 2020
Safety and immunogenicity of the α-synuclein active immunotherapeutic PD01A in patients with Parkinson's disease: a randomised, single-blinded, phase 1 trial.The Lancet. Neurology, , Volume: 19, Issue:7, 2020
Application of yeast to studying amyloid and prion diseases.Advances in genetics, , Volume: 105, 2020
Skin Biopsy May Help to Distinguish Multiple System Atrophy-Parkinsonism from Parkinson's Disease With Orthostatic Hypotension.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:9, 2020
Alpha-Synuclein Oligomers and Neurofilament Light Chain in Spinal Fluid Differentiate Multiple System Atrophy from Lewy Body Synucleinopathies.Annals of neurology, , Volume: 88, Issue:3, 2020
Timing Is Everything: The T-Cell Response to α-Synuclein Is Maximal in Early Parkinson's.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:7, 2020
Novel Furan-2-yl-1ACS chemical neuroscience, , 08-05, Volume: 11, Issue:15, 2020
Crosstalk Between Alpha-Synuclein and Other Human and Non-Human Amyloidogenic Proteins: Consequences for Amyloid Formation in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 10, Issue:3, 2020
Alpha-Synuclein Dopaminylation Presented in Plasma of Both Healthy Subjects and Parkinson's Disease Patients.Proteomics. Clinical applications, , Volume: 14, Issue:5, 2020
Oxidized nicotinamide adenine dinucleotide-dependent mitochondrial deacetylase sirtuin-3 as a potential therapeutic target of Parkinson's disease.Ageing research reviews, , Volume: 62, 2020
A Longitudinal Skin Biopsy Study of Phosphorylated Alpha-Synuclein in a Patient With Parkinson Disease and Orthostatic Hypotension.Journal of neuropathology and experimental neurology, , 07-01, Volume: 79, Issue:7, 2020
The Possible Protective Role of α-Synuclein Against Severe Acute Respiratory Syndrome Coronavirus 2 Infections in Patients With Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:8, 2020
α-Synuclein aggregation nucleates through liquid-liquid phase separation.Nature chemistry, , Volume: 12, Issue:8, 2020
Single-vesicle imaging reveals lipid-selective and stepwise membrane disruption by monomeric α-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , 06-23, Volume: 117, Issue:25, 2020
Distinct residual and disordered structures of alpha-synuclein analyzed by amide-proton exchange and NMR signal intensity.Biochimica et biophysica acta. Proteins and proteomics, , Volume: 1868, Issue:9, 2020
Novel drug delivery systems of β2 adrenoreceptor agonists to suppress SNCA gene expression and mitochondrial oxidative stress in Parkinson's disease management.Expert opinion on drug delivery, , Volume: 17, Issue:8, 2020
Intracellular delivery of Parkin rescues neurons from accumulation of damaged mitochondria and pathological α-synuclein.Science advances, , Volume: 6, Issue:18, 2020
Biophysical studies of protein misfolding and aggregation in Quarterly reviews of biophysics, , 06-04, Volume: 49, 2020
Healthspan Enhancement by Olive Polyphenols in International journal of molecular sciences, , May-29, Volume: 21, Issue:11, 2020
Interaction between SNCA gene polymorphisms and T2DM with Parkinson's disease.Acta neurologica Scandinavica, , Volume: 142, Issue:5, 2020
Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease.Aging cell, , Volume: 19, Issue:6, 2020
Improvement of Impaired Motor Functions by Human Dental Exfoliated Deciduous Teeth Stem Cell-Derived Factors in a Rat Model of Parkinson's Disease.International journal of molecular sciences, , May-27, Volume: 21, Issue:11, 2020
A novel multi-marker discovery approach identifies new serum biomarkers for Parkinson's disease in older people: an EXosomes in PArkiNson Disease (EXPAND) ancillary study.GeroScience, , Volume: 42, Issue:5, 2020
Parkinson's disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure.Nature communications, , 05-26, Volume: 11, Issue:1, 2020
Anti-aggregation Effects of Phenolic Compounds on α-synuclein.Molecules (Basel, Switzerland), , May-24, Volume: 25, Issue:10, 2020
Alteration of the Conformational Dynamics of a DNA Hairpin by α-Synuclein in the Presence of Aqueous Two-Phase Systems.Chemistry (Weinheim an der Bergstrasse, Germany), , Aug-26, Volume: 26, Issue:48, 2020
Increased alpha-synuclein tear fluid levels in patients with Parkinson's disease.Scientific reports, , 05-22, Volume: 10, Issue:1, 2020
Detection and Assessment of α-Synuclein Oligomers in the Urine of Parkinson's Disease Patients.Journal of Parkinson's disease, , Volume: 10, Issue:3, 2020
SNCA Hypomethylation in Rapid Eye Movement Sleep Behavior Disorder Is a Potential Biomarker for Parkinson's Disease.Journal of Parkinson's disease, , Volume: 10, Issue:3, 2020
Modelling cognitive deficits in Parkinson's disease: Is CA2 a gateway for hippocampal synucleinopathy?Experimental neurology, , Volume: 330, 2020
Reply: ARSA gene variants and Parkinson's disease.Brain : a journal of neurology, , 06-01, Volume: 143, Issue:6, 2020
ARSA gene variants and Parkinson's disease.Brain : a journal of neurology, , 06-01, Volume: 143, Issue:6, 2020
Simple and Complex Sugars in Parkinson's Disease: a Bittersweet Taste.Molecular neurobiology, , Volume: 57, Issue:7, 2020
Reduced oligodendrocyte exosome secretion in multiple system atrophy involves SNARE dysfunction.Brain : a journal of neurology, , 06-01, Volume: 143, Issue:6, 2020
Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates.Science advances, , Volume: 6, Issue:20, 2020
Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity.Scientific reports, , 05-18, Volume: 10, Issue:1, 2020
Immunization therapies for Parkinson's disease: state of the art and considerations for future clinical trials.Expert opinion on investigational drugs, , Volume: 29, Issue:7, 2020
Generation of a human induced pluripotent stem cell line derived from a Parkinson's disease patient carrying SNCA duplication.Stem cell research, , Volume: 45, 2020
Cerebrospinal Fluid Cytokines and Neurodegeneration-Associated Proteins in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:6, 2020
A Novel Tool to Investigate the Early and Late Stages of α-Synuclein Aggregation.ACS chemical neuroscience, , 06-03, Volume: 11, Issue:11, 2020
Clinical characterization of patients with leucine-rich repeat kinase 2 genetic variants in Japan.Journal of human genetics, , Volume: 65, Issue:9, 2020
Structural analyses and force fields comparison for NACore (68-78) and SubNACore (69-77) fibril segments of Parkinson's disease.Journal of molecular modeling, , May-12, Volume: 26, Issue:6, 2020
Lipids: Key Players That Modulate α-Synuclein Toxicity and Neurodegeneration in Parkinson's Disease.International journal of molecular sciences, , May-07, Volume: 21, Issue:9, 2020
Glucocerebrosidase deficiency promotes release of α-synuclein fibrils from cultured neurons.Human molecular genetics, , 06-27, Volume: 29, Issue:10, 2020
Intramitochondrial proteostasis is directly coupled to α-synuclein and amyloid β1-42 pathologies.The Journal of biological chemistry, , 07-24, Volume: 295, Issue:30, 2020
Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates.Brain : a journal of neurology, , 05-01, Volume: 143, Issue:5, 2020
α-Synuclein Regulates Iron Homeostasis via Preventing Parkin-Mediated DMT1 Ubiquitylation in Parkinson's Disease Models.ACS chemical neuroscience, , 06-03, Volume: 11, Issue:11, 2020
CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson's disease: a study in LRRK2 mutation carriers.Translational neurodegeneration, , 05-06, Volume: 9, Issue:1, 2020
Chronic Systemic Exposure to Low-Dose Rotenone Induced Central and Peripheral Neuropathology and Motor Deficits in Mice: Reproducible Animal Model of Parkinson's Disease.International journal of molecular sciences, , May-04, Volume: 21, Issue:9, 2020
The dual role of c-src in cell-to-cell transmission of α-synuclein.EMBO reports, , 07-03, Volume: 21, Issue:7, 2020
Carboxy-terminal truncation and phosphorylation of α-synuclein elongates survival in a prion-like seeding mouse model of synucleinopathy.Neuroscience letters, , 07-27, Volume: 732, 2020
Variants in the Niemann-Pick type C gene NPC1 are not associated with Parkinson's disease.Neurobiology of aging, , Volume: 93, 2020
A myosin-7B-dependent endocytosis pathway mediates cellular entry of α-synuclein fibrils and polycation-bearing cargos.Proceedings of the National Academy of Sciences of the United States of America, , 05-19, Volume: 117, Issue:20, 2020
Alpha-Synuclein and LRRK2 in Synaptic Autophagy: Linking Early Dysfunction to Late-Stage Pathology in Parkinson's Disease.Cells, , 04-30, Volume: 9, Issue:5, 2020
Specific Knockdown of α-Synuclein by Peptide-Directed Proteasome Degradation Rescued Its Associated Neurotoxicity.Cell chemical biology, , 06-18, Volume: 27, Issue:6, 2020
Calbindin-DCellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , May-02, Volume: 54, Issue:3, 2020
A Master Regulator of α-Synuclein Aggregation.ACS chemical neuroscience, , 05-20, Volume: 11, Issue:10, 2020
Synj1 haploinsufficiency causes dopamine neuron vulnerability and alpha-synuclein accumulation in mice.Human molecular genetics, , 08-11, Volume: 29, Issue:14, 2020
The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson's disease, multiple system atrophy and dementia with Lewy bodies.Acta neuropathologica, , Volume: 139, Issue:6, 2020
Microglial exosomes facilitate α-synuclein transmission in Parkinson's disease.Brain : a journal of neurology, , 05-01, Volume: 143, Issue:5, 2020
Enhanced Susceptibility of PINK1 Knockout Rats to α-Synuclein Fibrils.Neuroscience, , 06-15, Volume: 437, 2020
Polymorphic α-Synuclein Strains Modified by Dopamine and Docosahexaenoic Acid Interact Differentially with Tau Protein.Molecular neurobiology, , Volume: 57, Issue:6, 2020
S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson's disease.PloS one, , Volume: 15, Issue:4, 2020
Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation.Cell death and differentiation, , Volume: 27, Issue:10, 2020
Unilateral intranigral administration of β-sitosterol β-D-glucoside triggers pathological α-synuclein spreading and bilateral nigrostriatal dopaminergic neurodegeneration in the rat.Acta neuropathologica communications, , 04-22, Volume: 8, Issue:1, 2020
The role of alpha-synuclein as ferrireductase in neurodegeneration associated with Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 127, Issue:5, 2020
α-synuclein inclusions are abundant in non-neuronal cells in the anterior olfactory nucleus of the Parkinson's disease olfactory bulb.Scientific reports, , 04-21, Volume: 10, Issue:1, 2020
Analysis of Protein Conformational Strains-A Key for New Diagnostic Methods of Human Diseases.International journal of molecular sciences, , Apr-17, Volume: 21, Issue:8, 2020
α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson's disease.Nature communications, , 04-20, Volume: 11, Issue:1, 2020
α-Synucleinopathy associated c-Abl activation causes p53-dependent autophagy impairment.Molecular neurodegeneration, , 04-16, Volume: 15, Issue:1, 2020
A novel, label-free liquid crystal biosensor for Parkinson's disease related alpha-synuclein.Chemical communications (Cambridge, England), , May-19, Volume: 56, Issue:40, 2020
Structural basis of the interplay between α-synuclein and Tau in regulating pathological amyloid aggregation.The Journal of biological chemistry, , 05-22, Volume: 295, Issue:21, 2020
Chemical Chaperones as Novel Drugs for Parkinson's Disease.Trends in molecular medicine, , Volume: 26, Issue:4, 2020
Healthspan Maintenance and Prevention of Parkinson's-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in International journal of molecular sciences, , Apr-08, Volume: 21, Issue:7, 2020
The Interplay Between Proteostasis Systems and Parkinson's Disease.Advances in experimental medicine and biology, , Volume: 1233, 2020
Novel biomarkers for the evaluation of aging-induced proteinopathies.Biogerontology, , Volume: 21, Issue:5, 2020
Noncanonical Roles of hNeural plasticity, , Volume: 2020, 2020
Inhibition of HDAC6 activity protects dopaminergic neurons from alpha-synuclein toxicity.Scientific reports, , 04-08, Volume: 10, Issue:1, 2020
Biological links between traumatic brain injury and Parkinson's disease.Acta neuropathologica communications, , 04-07, Volume: 8, Issue:1, 2020
[no title available]Journal of integrative neuroscience, , Mar-30, Volume: 19, Issue:1, 2020
Tianma Gouteng granules decreases the susceptibility of Parkinson's disease by inhibiting ALOX15-mediated lipid peroxidation.Journal of ethnopharmacology, , Jun-28, Volume: 256, 2020
Selective neuronal vulnerability in Parkinson's disease.Progress in brain research, , Volume: 252, 2020
Novel approaches to counter protein aggregation pathology in Parkinson's disease.Progress in brain research, , Volume: 252, 2020
The gut microbiome in Parkinson's disease: A culprit or a bystander?Progress in brain research, , Volume: 252, 2020
Pathways of protein synthesis and degradation in PD pathogenesis.Progress in brain research, , Volume: 252, 2020
The Promise and Challenges of Developing miRNA-Based Therapeutics for Parkinson's Disease.Cells, , 03-31, Volume: 9, Issue:4, 2020
A common polymorphism in Journal of neurology, neurosurgery, and psychiatry, , Volume: 91, Issue:6, 2020
Long Noncoding RNA POU3F3 and α-Synuclein in Plasma L1CAM Exosomes Combined with β-Glucocerebrosidase Activity: Potential Predictors of Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 17, Issue:3, 2020
Peripheral alpha-synuclein levels in patients with genetic and non-genetic forms of Parkinson's disease.Parkinsonism & related disorders, , Volume: 73, 2020
Role of Alcohol Drinking in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis.International journal of molecular sciences, , Mar-27, Volume: 21, Issue:7, 2020
A role for α-Synuclein in axon growth and its implications in corticostriatal glutamatergic plasticity in Parkinson's disease.Molecular neurodegeneration, , 03-30, Volume: 15, Issue:1, 2020
Structure of a Parkinson's Disease-Involved α-Synuclein Peptide Is Modulated by Membrane Composition and Physical State.The journal of physical chemistry. B, , 04-30, Volume: 124, Issue:17, 2020
Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice.Neurobiology of aging, , Volume: 91, 2020
Biofluid Biomarkers in Parkinson's Disease: Clarity Amid Controversy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:7, 2020
What and How Can Physical Activity Prevention Function on Parkinson's Disease?Oxidative medicine and cellular longevity, , Volume: 2020, 2020
The function of bacterial HtrA is evolutionally conserved in mammalian HtrA2/Omi.Scientific reports, , 03-24, Volume: 10, Issue:1, 2020
Long-term post-mortem studies following neurturin gene therapy in patients with advanced Parkinson's disease.Brain : a journal of neurology, , 03-01, Volume: 143, Issue:3, 2020
Protein transmission in neurodegenerative disease.Nature reviews. Neurology, , Volume: 16, Issue:4, 2020
Lipids as the key to understanding α-synuclein behaviour in Parkinson disease.Nature reviews. Molecular cell biology, , Volume: 21, Issue:7, 2020
Cryo-EM structure of full-length α-synuclein amyloid fibril with Parkinson's disease familial A53T mutation.Cell research, , Volume: 30, Issue:4, 2020
Disease-Specific Strains of α-Synuclein in Multiple System Atrophy and Parkinson's Disease: But Why?Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:5, 2020
Conjugal multiple system atrophy: Be wary of implicating transmissibility.Parkinsonism & related disorders, , Volume: 75, 2020
Aggregation and Cellular Toxicity of Pathogenic or Non-pathogenic Proteins.Scientific reports, , 03-20, Volume: 10, Issue:1, 2020
Insulin Resistance Promotes Parkinson's Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling.Cells, , 03-17, Volume: 9, Issue:3, 2020
Potential sources of interference with the highly sensitive detection and quantification of alpha-synuclein seeds by qRT-QuIC.FEBS open bio, , Volume: 10, Issue:5, 2020
The Aggregation Conditions Define Whether EGCG is an Inhibitor or Enhancer of International journal of molecular sciences, , Mar-14, Volume: 21, Issue:6, 2020
Serum Uric Acid Level as a Biomarker in Idiopathic and Genetic (p.A53T Alpha-Synuclein Carriers) Parkinson's Disease: Data from the PPMI Study.Journal of Parkinson's disease, , Volume: 10, Issue:2, 2020
Downregulation of α-Synuclein Protein Levels by an Intracellular Single-Chain Antibody.Journal of Parkinson's disease, , Volume: 10, Issue:2, 2020
Advances in modelling alpha-synuclein-induced Parkinson's diseases in rodents: Virus-based models versus inoculation of exogenous preformed toxic species.Journal of neuroscience methods, , 05-15, Volume: 338, 2020
Mutated ATP10B increases Parkinson's disease risk by compromising lysosomal glucosylceramide export.Acta neuropathologica, , Volume: 139, Issue:6, 2020
Differential effects of CuBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, , Volume: 33, Issue:2-3, 2020
Autonomic dysfunction is associated with neuropsychological impairment in Lewy body disease.Journal of neurology, , Volume: 267, Issue:7, 2020
Salient Features of Monomeric Alpha-Synuclein Revealed by NMR Spectroscopy.Biomolecules, , 03-10, Volume: 10, Issue:3, 2020
Demonstration of brain region-specific neuronal vulnerability in human iPSC-based model of familial Parkinson's disease.Human molecular genetics, , 05-08, Volume: 29, Issue:7, 2020
The Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils.ACS nano, , 05-26, Volume: 14, Issue:5, 2020
A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function.Nature structural & molecular biology, , Volume: 27, Issue:3, 2020
A longitudinal study on α-synuclein in plasma neuronal exosomes as a biomarker for Parkinson's disease development and progression.European journal of neurology, , Volume: 27, Issue:6, 2020
Investigating the Effects of O-GlcNAc Modifications in Parkinson's Disease Using Semisynthetic α-Synuclein.Methods in molecular biology (Clifton, N.J.), , Volume: 2133, 2020
Initiation and propagation of α-synuclein aggregation in the nervous system.Molecular neurodegeneration, , 03-06, Volume: 15, Issue:1, 2020
Targeting α-synuclein for PD Therapeutics: A Pursuit on All Fronts.Biomolecules, , 03-03, Volume: 10, Issue:3, 2020
Novel fatty acid-binding protein 3 ligand inhibits dopaminergic neuronal death and improves motor and cognitive impairments in Parkinson's disease model mice.Pharmacology, biochemistry, and behavior, , Volume: 191, 2020
Genetic causes of PD: A pathway to disease modification.Neuropharmacology, , 06-15, Volume: 170, 2020
Methods for detecting toxic α-synuclein species as a biomarker for Parkinson's disease.Critical reviews in clinical laboratory sciences, , Volume: 57, Issue:5, 2020
α-Synuclein fibrillation products trigger the release of hexokinase I from mitochondria: Protection by curcumin, and possible role in pathogenesis of Parkinson's disease.Biochimica et biophysica acta. Biomembranes, , 06-01, Volume: 1862, Issue:6, 2020
New insights on the structure of alpha-synuclein fibrils using cryo-electron microscopy.Current opinion in neurobiology, , Volume: 61, 2020
The Link between Gut Dysbiosis and Neuroinflammation in Parkinson's Disease.Neuroscience, , 04-15, Volume: 432, 2020
Interaction of α-synuclein and Parkin in iron toxicity on SH-SY5Y cells: implications in the pathogenesis of Parkinson's disease.The Biochemical journal, , 03-27, Volume: 477, Issue:6, 2020
Choroid plexus volume is associated with levels of CSF proteins: relevance for Alzheimer's and Parkinson's disease.Neurobiology of aging, , Volume: 89, 2020
Glucocerebrosidase as a therapeutic target for Parkinson's disease.Expert opinion on therapeutic targets, , Volume: 24, Issue:4, 2020
Iron-mediated interaction of alpha synuclein with lipid raft model membranes.Nanoscale, , Apr-14, Volume: 12, Issue:14, 2020
Synthesis and characterization of high affinity fluorogenic α-synuclein probes.Chemical communications (Cambridge, England), , Mar-24, Volume: 56, Issue:24, 2020
A Curcumin Derivative Activates TFEB and Protects Against Parkinsonian Neurotoxicity International journal of molecular sciences, , Feb-22, Volume: 21, Issue:4, 2020
PET Radiopharmaceuticals for Alzheimer's Disease and Parkinson's Disease Diagnosis, the Current and Future Landscape.Molecules (Basel, Switzerland), , Feb-21, Volume: 25, Issue:4, 2020
Implications of the Gut Microbiome in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:6, 2020
Quantitative Profiling of Synuclein Species: Application to Transgenic Mouse Models of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 10, Issue:2, 2020
Role of α-Synuclein Regions in Nucleation and Elongation of Amyloid Fiber Assembly.ACS chemical neuroscience, , 03-18, Volume: 11, Issue:6, 2020
Novel 1-hydroxypyridin-2-one metal chelators prevent and rescue ubiquitin proteasomal-related neuronal injury in an in vitro model of Parkinson's disease.Archives of toxicology, , Volume: 94, Issue:3, 2020
The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration.Proceedings of the National Academy of Sciences of the United States of America, , 03-03, Volume: 117, Issue:9, 2020
The Properties of α-Synuclein Secondary Nuclei Are Dominated by the Solution Conditions Rather than the Seed Fibril Strain.ACS chemical neuroscience, , 03-18, Volume: 11, Issue:6, 2020
Chemoenzymatic Semisynthesis of Phosphorylated α-Synuclein Enables Identification of a Bidirectional Effect on Fibril Formation.ACS chemical biology, , 03-20, Volume: 15, Issue:3, 2020
Tears - more to them than meets the eye: why tears are a good source of biomarkers in Parkinson's disease.Biomarkers in medicine, , Volume: 14, Issue:2, 2020
Back and to the Future: From Neurotoxin-Induced to Human Parkinson's Disease Models.Current protocols in neuroscience, , Volume: 91, Issue:1, 2020
A new MAP-Rasagiline conjugate reduces α-synuclein inclusion formation in a cell model.Pharmacological reports : PR, , Volume: 72, Issue:2, 2020
Elevated Serum α-Synuclein Levels in Huntington's Disease Patients.Neuroscience, , 04-01, Volume: 431, 2020
Neurodegenerative diseases distinguished through protein-structure analysis.Nature, , Volume: 578, Issue:7794, 2020
Replication-Based Rearrangements Are a Common Mechanism for SNCA Duplication in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:5, 2020
Disentangling aggregation-prone proteins: a new method for isolating α-synuclein species: An Editorial Highlight for "A simple, versatile and robust centrifugation-based filtration protocol for the isolation and quantification of α-synuclein monomers, oliJournal of neurochemistry, , Volume: 153, Issue:1, 2020
[Emerging Disease-modifying Strategies Targeting α-synuclein in Parkinson's Disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:2, 2020
[α-Synuclein as Diagnostic Biomarker].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:2, 2020
[Perspective of α-synuclein and Familial Parkinson's Disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:2, 2020
[REM Sleep Behavior Disorder and α-synucleinopathy].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:2, 2020
Synergy between plasminogen activator inhibitor-1, α-synuclein, and neuroinflammation in Parkinson's disease.Medical hypotheses, , Volume: 138, 2020
Alpha-synuclein/synapsin III pathological interplay boosts the motor response to methylphenidate.Neurobiology of disease, , Volume: 138, 2020
Identification of potential natural neuroprotective molecules for Parkinson's disease by using chemoinformatics and molecular docking.Journal of molecular graphics & modelling, , Volume: 97, 2020
A Self-Assembled α-Synuclein Nanoscavenger for Parkinson's Disease.ACS nano, , 02-25, Volume: 14, Issue:2, 2020
Parkinson's disease and iron.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 127, Issue:2, 2020
Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy.Nature, , Volume: 578, Issue:7794, 2020
The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure.Proceedings of the National Academy of Sciences of the United States of America, , 02-18, Volume: 117, Issue:7, 2020
Copper Ions and Parkinson's Disease: Why Is Homeostasis So Relevant?Biomolecules, , 01-29, Volume: 10, Issue:2, 2020
Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson's disease.Brain, behavior, and immunity, , Volume: 87, 2020
Amyloid aggregates of the deubiquitinase OTUB1 are neurotoxic, suggesting that they contribute to the development of Parkinson's disease.The Journal of biological chemistry, , 03-13, Volume: 295, Issue:11, 2020
Co-Existence of tau and α-synuclein pathology in fetal graft tissue at autopsy: A case report.Parkinsonism & related disorders, , Volume: 71, 2020
In search of Parkinson's disease biomarkers - is the answer in our mouths? A systematic review of the literature on salivary biomarkers of Parkinson's disease.Neurologia i neurochirurgia polska, , Volume: 54, Issue:1, 2020
6-OH-BDE-47 exposure-induced Parkinson's disease pathology in Sprague Dawley rat.The Science of the total environment, , Apr-01, Volume: 711, 2020
Rasagiline and selegiline modulate mitochondrial homeostasis, intervene apoptosis system and mitigate α-synuclein cytotoxicity in disease-modifying therapy for Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 127, Issue:2, 2020
N-terminal acetylation mutants affect alpha-synuclein stability, protein levels and neuronal toxicity.Neurobiology of disease, , Volume: 137, 2020
The contribution of Parkin, PINK1 and DJ-1 genes to selective neuronal degeneration in Parkinson's disease.The European journal of neuroscience, , Volume: 52, Issue:4, 2020
iPSC modeling of young-onset Parkinson's disease reveals a molecular signature of disease and novel therapeutic candidates.Nature medicine, , Volume: 26, Issue:2, 2020
If not salivary alpha-synuclein, then what? A look at potential Parkinson's disease biomarkers.Expert review of molecular diagnostics, , Volume: 20, Issue:4, 2020
Immunotherapy for Parkinson's disease.Neurobiology of disease, , Volume: 137, 2020
Alterations in α-synuclein and PINK1 expression reduce neurite length and induce mitochondrial fission and Golgi fragmentation in midbrain neurons.Neuroscience letters, , 02-16, Volume: 720, 2020
Fine-Mapping of SNCA in Rapid Eye Movement Sleep Behavior Disorder and Overt Synucleinopathies.Annals of neurology, , Volume: 87, Issue:4, 2020
Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4.Journal of immunology (Baltimore, Md. : 1950), , 03-01, Volume: 204, Issue:5, 2020
The biochemical basis of interactions between Glucocerebrosidase and alpha-synuclein in GBA1 mutation carriers.Journal of neurochemistry, , Volume: 154, Issue:1, 2020
Dysregulated Interorganellar Crosstalk of Mitochondria in the Pathogenesis of Parkinson's Disease.Cells, , 01-17, Volume: 9, Issue:1, 2020
TGF-β/Smad3 Signalling Modulates GABA Neurotransmission: Implications in Parkinson's Disease.International journal of molecular sciences, , Jan-16, Volume: 21, Issue:2, 2020
Dysbiosis in Parkinson's disease might be triggered by certain antibiotics.Medical hypotheses, , Volume: 137, 2020
Generation of an induced pluripotent stem cell line (CSC-32) from a patient with Parkinson's disease carrying a heterozygous variation p.A53T in the SNCA gene.Stem cell research, , Volume: 43, 2020
Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans.Cell reports, , 01-14, Volume: 30, Issue:2, 2020
Scutellarin inhibits the uninduced and metal-induced aggregation of α-Synuclein and disaggregates preformed fibrils: implications for Parkinson's disease.The Biochemical journal, , 02-14, Volume: 477, Issue:3, 2020
Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway.Molecular neurodegeneration, , 01-13, Volume: 15, Issue:1, 2020
A simple, versatile and robust centrifugation-based filtration protocol for the isolation and quantification of α-synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in α-synuclein research.Journal of neurochemistry, , Volume: 153, Issue:1, 2020
Systemic activation of NLRP3 inflammasome and plasma α-synuclein levels are correlated with motor severity and progression in Parkinson's disease.Journal of neuroinflammation, , Jan-08, Volume: 17, Issue:1, 2020
Novel Therapeutics for the Treatment of Alzheimer's and Parkinson's Disease.Current pharmaceutical design, , Volume: 26, Issue:7, 2020
[Current Status and Future Prospects of Therapeutic Development of Parkinson's Disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:1, 2020
A new avenue for treating Parkinson's disease targeted at aggrephagy modulation and neuroinflammation: Insights from in vitro and animal studies.EBioMedicine, , Volume: 51, 2020
NK cells clear α-synuclein and the depletion of NK cells exacerbates synuclein pathology in a mouse model of α-synucleinopathy.Proceedings of the National Academy of Sciences of the United States of America, , 01-21, Volume: 117, Issue:3, 2020
Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult.Neuron, , 03-04, Volume: 105, Issue:5, 2020
Inhibition of synucleinopathic seeding by rationally designed inhibitors.eLife, , 01-02, Volume: 9, 2020
Correlation between Cellular Uptake and Cytotoxicity of Fragmented α-Synuclein Amyloid Fibrils Suggests Intracellular Basis for Toxicity.ACS chemical neuroscience, , 02-05, Volume: 11, Issue:3, 2020
p38 MAPK-DRP1 signaling is involved in mitochondrial dysfunction and cell death in mutant A53T α-synuclein model of Parkinson's disease.Toxicology and applied pharmacology, , 02-01, Volume: 388, 2020
The neuroprotective effect of fullerenols on a model of Parkinson's disease in Drosophila melanogaster.Biochemical and biophysical research communications, , 03-05, Volume: 523, Issue:2, 2020
Integrated Plasma and Neuroimaging Biomarkers Associated with Motor and Cognition Severity in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 10, Issue:1, 2020
Association between SNCA rs356220 polymorphism and Parkinson's disease: A meta-analysis.Neuroscience letters, , 01-19, Volume: 717, 2020
A multi-faceted genotoxic network of alpha-synuclein in the nucleus and mitochondria of dopaminergic neurons in Parkinson's disease: Emerging concepts and challenges.Progress in neurobiology, , Volume: 185, 2020
[no title available]ChemMedChem, , 03-05, Volume: 15, Issue:5, 2020
Reduced cerebral blood flow in an Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 40, Issue:12, 2020
Interactions between Soluble Species of β-Amyloid and α-Synuclein Promote Oligomerization while Inhibiting Fibrillization.Biochemistry, , 02-04, Volume: 59, Issue:4, 2020
The gut in Parkinson's disease: Bottom-up, top-down, or neither?Neurogastroenterology and motility, , Volume: 32, Issue:1, 2020
Global ubiquitome analysis of substantia nigra in doubly-mutant human alpha-synuclein transgenic mice.Behavioural brain research, , 02-17, Volume: 380, 2020
Behavioral defects associated with amygdala and cortical dysfunction in mice with seeded α-synuclein inclusions.Neurobiology of disease, , Volume: 134, 2020
Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease.Neurobiology of disease, , Volume: 136, 2020
α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson's disease model.Brain : a journal of neurology, , 01-01, Volume: 143, Issue:1, 2020
Ubiquitination Can Change the Structure of the α-Synuclein Amyloid Fiber in a Site Selective Fashion.The Journal of organic chemistry, , 02-07, Volume: 85, Issue:3, 2020
Salivary microR-153 and microR-223 Levels as Potential Diagnostic Biomarkers of Idiopathic Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:3, 2020
Circulating Brain-enriched MicroRNAs for detection and discrimination of idiopathic and genetic Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:3, 2020
Loss of fragile X mental retardation protein precedes Lewy pathology in Parkinson's disease.Acta neuropathologica, , Volume: 139, Issue:2, 2020
Mycobacterial immunomodulation and viral manipulation of neuronal copper efflux in the setting of sporadic Parkinson's disease: A multi - hit, outside - in hypothesis of its pathogenesis.Medical hypotheses, , Volume: 136, 2020
Dopamine D3 receptor: A neglected participant in Parkinson Disease pathogenesis and treatment?Ageing research reviews, , Volume: 57, 2020
Autophagy lysosomal pathway dysfunction in Parkinson's disease; evidence from human genetics.Parkinsonism & related disorders, , Volume: 73, 2020
GBA1 mutations: Prospects for exosomal biomarkers in α-synuclein pathologies.Molecular genetics and metabolism, , Volume: 129, Issue:2, 2020
Gold-nanourchin seeded single-walled carbon nanotube on voltammetry sensor for diagnosing neurogenerative Parkinson's disease.Analytica chimica acta, , Jan-15, Volume: 1094, 2020
α-Synuclein real-time quaking-induced conversion in the submandibular glands of Parkinson's disease patients.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:2, 2020
Association between alpha-synuclein (SNCA) rs11931074 variability and susceptibility to Parkinson's disease: an updated meta-analysis of 41,811 patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 41, Issue:2, 2020
Insight into the molecular mechanism underlying the inhibition of α-synuclein aggregation by hydroxytyrosol.Biochemical pharmacology, , Volume: 173, 2020
Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia.Brain : a journal of neurology, , 01-01, Volume: 143, Issue:1, 2020
O-GlcNAcylation of truncated NAC segment alters peptide-dependent effects on α-synuclein aggregation.Bioorganic chemistry, , Volume: 94, 2020
Doublecortin-like Kinase 1 Regulates α-Synuclein Levels and Toxicity.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 01-08, Volume: 40, Issue:2, 2020
3,4-Dihydroxyphenylacetaldehyde Is More Efficient than Dopamine in Oligomerizing and Quinonizing The Journal of pharmacology and experimental therapeutics, , Volume: 372, Issue:2, 2020
CSF or serum neurofilament light added to α-Synuclein panel discriminates Parkinson's from controls.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:2, 2020
Apoptosis signal regulating kinase 1 deletion mitigates α-synuclein pre-formed fibril propagation in mice.Neurobiology of aging, , Volume: 85, 2020
The vicious cycle between α-synuclein aggregation and autophagic-lysosomal dysfunction.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:1, 2020
Bioluminescence Imaging of Neuroinflammation in a Mouse Model of Parkinson's Disease.Methods in molecular biology (Clifton, N.J.), , Volume: 2081, 2020
Inflammasome and α-synuclein in Parkinson's disease: A cross-sectional study.Journal of neuroimmunology, , 01-15, Volume: 338, 2020
The good and bad of therapeutic strategies that directly target α-synuclein.IUBMB life, , Volume: 72, Issue:4, 2020
Systemic activation of Nrf2 pathway in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:1, 2020
Parkinson's Disease: Glucocerebrosidase 1 Mutation Severity Is Associated with CSF Alpha-Synuclein Profiles.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:3, 2020
A characterization of Gaucher iPS-derived astrocytes: Potential implications for Parkinson's disease.Neurobiology of disease, , Volume: 134, 2020
Initiation of Parkinson's disease from gut to brain by δ-secretase.Cell research, , Volume: 30, Issue:1, 2020
Biomarkers for Parkinson's Disease: How Good Are They?Neuroscience bulletin, , Volume: 36, Issue:2, 2020
Structurally distinct α-synuclein fibrils induce robust parkinsonian pathology.Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:2, 2020
Glucocerebrosidase activity, cathepsin D and monomeric α-synuclein interactions in a stem cell derived neuronal model of a PD associated GBA1 mutation.Neurobiology of disease, , Volume: 134, 2020
Neural connectivity predicts spreading of alpha-synuclein pathology in fibril-injected mouse models: Involvement of retrograde and anterograde axonal propagation.Neurobiology of disease, , Volume: 134, 2020
Open questions on the nature of Parkinson's disease: from triggers to spreading pathology.Journal of medical genetics, , Volume: 57, Issue:2, 2020
Recuperative effect of metformin loaded polydopamine nanoformulation promoting EZH2 mediated proteasomal degradation of phospho-α-synuclein in Parkinson's disease model.Nanomedicine : nanotechnology, biology, and medicine, , Volume: 24, 2020
Microbubble-facilitated ultrasound pulsation promotes direct α-synuclein gene delivery.Biochemical and biophysical research communications, , 09-10, Volume: 517, Issue:1, 2019
Association of rs356219 and rs3822086 polymorphisms with the risk of Parkinson's disease: A meta-analysis.Neuroscience letters, , 09-14, Volume: 709, 2019
Poly-ADP-ribose assisted protein localization resolves that DJ-1, but not LRRK2 or α-synuclein, is localized to the mitochondrial matrix.PloS one, , Volume: 14, Issue:7, 2019
Value of in vivo α-synuclein deposits in Parkinson's disease: A systematic review and meta-analysis.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:10, 2019
Mechanistic Insight into the Binding Profile of DCVJ and α-Synuclein Fibril Revealed by Multiscale Simulations.ACS chemical neuroscience, , 01-16, Volume: 10, Issue:1, 2019
Abnormal α-synuclein deposits in skin nerves: intra- and inter-laboratory reproducibility.European journal of neurology, , Volume: 26, Issue:10, 2019
Modulating α-synuclein fibril formation using DNA tetrahedron nanostructures.Biochimica et biophysica acta. General subjects, , Volume: 1863, Issue:1, 2019
The relationship between inflammatory bowel disease and Parkinson's disease: true or fiction?Scandinavian journal of gastroenterology, , Volume: 54, Issue:7, 2019
Tetramethylpyrazine Analogue T-006 Promotes the Clearance of Alpha-synuclein by Enhancing Proteasome Activity in Parkinson's Disease Models.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 16, Issue:4, 2019
Arylsulfatase A, a genetic modifier of Parkinson's disease, is an α-synuclein chaperone.Brain : a journal of neurology, , 09-01, Volume: 142, Issue:9, 2019
New models show gut-brain transmission of Parkinson disease pathology.Nature reviews. Neurology, , Volume: 15, Issue:9, 2019
rAAV-based brain slice culture models of Alzheimer's and Parkinson's disease inclusion pathologies.The Journal of experimental medicine, , 03-04, Volume: 216, Issue:3, 2019
Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay.Journal of visualized experiments : JoVE, , 06-25, Issue:148, 2019
Exosomes from patients with Parkinson's disease are pathological in mice.Journal of molecular medicine (Berlin, Germany), , Volume: 97, Issue:9, 2019
Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity.Redox biology, , Volume: 22, 2019
Development of FABP3 ligands that inhibit arachidonic acid-induced α-synuclein oligomerization.Brain research, , 03-15, Volume: 1707, 2019
Peripheral Inflammation Regulates CNS Immune Surveillance Through the Recruitment of Inflammatory Monocytes Upon Systemic α-Synuclein Administration.Frontiers in immunology, , Volume: 10, 2019
Structural Insights into α-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations.Journal of molecular biology, , 09-06, Volume: 431, Issue:19, 2019
Interplay between α-synuclein amyloid formation and membrane structure.Biochimica et biophysica acta. Proteins and proteomics, , Volume: 1867, Issue:5, 2019
Age- and α-Synuclein-Dependent Degeneration of Dopamine and Noradrenaline Neurons in the Annual Killifish Nothobranchius furzeri.Cell reports, , 02-12, Volume: 26, Issue:7, 2019
Can GBA1-Associated Parkinson Disease Be Modeled in the Mouse?Trends in neurosciences, , Volume: 42, Issue:9, 2019
Non-Cell-Autonomous Neurotoxicity in Parkinson's Disease Mediated by Astroglial α-Synuclein.Stem cell reports, , 02-12, Volume: 12, Issue:2, 2019
Nucleic Acid-Based Therapeutics for Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 16, Issue:2, 2019
A30P mutant α-synuclein impairs autophagic flux by inactivating JNK signaling to enhance ZKSCAN3 activity in midbrain dopaminergic neurons.Cell death & disease, , 02-12, Volume: 10, Issue:2, 2019
Methionine oxidation in α-synuclein inhibits its propensity for ordered secondary structure.The Journal of biological chemistry, , 04-05, Volume: 294, Issue:14, 2019
Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons.Human molecular genetics, , 06-15, Volume: 28, Issue:12, 2019
Association between physical activity and dementia's risk factors in patients with Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 126, Issue:3, 2019
Toll-like receptors and their therapeutic potential in Parkinson's disease and α-synucleinopathies.Brain, behavior, and immunity, , Volume: 81, 2019
New Era in disease modification in Parkinson's disease: Review of genetically targeted therapeutics.Parkinsonism & related disorders, , Volume: 59, 2019
Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases.Neurology, , 02-12, Volume: 92, Issue:7, 2019
α-synuclein-lipoprotein interactions and elevated ApoE level in cerebrospinal fluid from Parkinson's disease patients.Proceedings of the National Academy of Sciences of the United States of America, , 07-23, Volume: 116, Issue:30, 2019
Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies.Cell reports, , 07-02, Volume: 28, Issue:1, 2019
The physiological role of α-synuclein and its relationship to Parkinson's Disease.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
The A30P α-synuclein mutation decreases subventricular zone proliferation.Human molecular genetics, , 07-15, Volume: 28, Issue:14, 2019
Clinical Trial Highlights: Targetting Alpha-Synuclein.Journal of Parkinson's disease, , Volume: 9, Issue:1, 2019
Parkinson's disease biomarkers based on α-synuclein.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Functionalization of the TMEM175 p.M393T variant as a risk factor for Parkinson disease.Human molecular genetics, , 10-01, Volume: 28, Issue:19, 2019
The Role of NOX4 in Parkinson's Disease with Dementia.International journal of molecular sciences, , Feb-06, Volume: 20, Issue:3, 2019
Multiple molecular pathways stimulating macroautophagy protect from alpha-synuclein-induced toxicity in human neurons.Neuropharmacology, , 05-01, Volume: 149, 2019
Phosphorylated α-synuclein deposits in sural nerve deriving from Schwann cells: A biomarker for Parkinson's disease.Parkinsonism & related disorders, , Volume: 60, 2019
Pathogenesis-targeted therapeutic strategies in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:1, 2019
[Prion-like Propagation of Pathological α-Synuclein in Vivo].Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, , Volume: 139, Issue:7, 2019
The prion-like propagation hypothesis in Alzheimer's and Parkinson's disease.Current opinion in neurology, , Volume: 32, Issue:2, 2019
Neuronal microtubules and proteins linked to Parkinson's disease: a relevant interaction?Biological chemistry, , 08-27, Volume: 400, Issue:9, 2019
Retinal α-synuclein deposits in Parkinson's disease patients and animal models.Acta neuropathologica, , Volume: 137, Issue:3, 2019
Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats.Acta neuropathologica, , Volume: 138, Issue:4, 2019
Moving forward the in vivo diagnosis of the synucleinopathies.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 29, Issue:6, 2019
Interpreting Genetic Variants: Hints from a Family Cluster of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 9, Issue:1, 2019
l-3,4-dihydroxyphenylalanine (l-DOPA) modulates brain iron, dopaminergic neurodegeneration and motor dysfunction in iron overload and mutant alpha-synuclein mouse models of Parkinson's disease.Journal of neurochemistry, , Volume: 150, Issue:1, 2019
A Proposed Roadmap for Parkinson's Disease Proof of Concept Clinical Trials Investigating Compounds Targeting Alpha-Synuclein.Journal of Parkinson's disease, , Volume: 9, Issue:1, 2019
Plasma alpha-synuclein levels in patients with Parkinson's disease: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 40, Issue:5, 2019
Alpha-Synuclein in Peripheral Tissues in Parkinson's Disease.ACS chemical neuroscience, , 02-20, Volume: 10, Issue:2, 2019
Studying Parkinson's disease using Caenorhabditis elegans models in microfluidic devices.Integrative biology : quantitative biosciences from nano to macro, , 05-01, Volume: 11, Issue:5, 2019
Multiplication of the SNCA locus exacerbates neuronal nuclear aging.Human molecular genetics, , 02-01, Volume: 28, Issue:3, 2019
SNCA rs11931074 polymorphism correlates with spontaneous brain activity and motor symptoms in Chinese patients with Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 126, Issue:8, 2019
Upregulation of the p53-p21 pathway by G2019S LRRK2 contributes to the cellular senescence and accumulation of α-synuclein.Cell cycle (Georgetown, Tex.), , Volume: 18, Issue:4, 2019
Novel Immunotherapeutic Approaches to Target Alpha-Synuclein and Related Neuroinflammation in Parkinson's Disease.Cells, , 01-31, Volume: 8, Issue:2, 2019
[Personalized treatment of Parkinson's disease].Der Nervenarzt, , Volume: 90, Issue:8, 2019
E46K mutant α-synuclein is more degradation resistant and exhibits greater toxic effects than wild-type α-synuclein in Drosophila models of Parkinson's disease.PloS one, , Volume: 14, Issue:6, 2019
A neuroscience perspective of the gut theory of Parkinson's disease.The European journal of neuroscience, , Volume: 49, Issue:6, 2019
PARP Inhibitors and Parkinson's Disease.The New England journal of medicine, , 01-31, Volume: 380, Issue:5, 2019
α-Synuclein in Parkinson's disease: causal or bystander?Journal of neural transmission (Vienna, Austria : 1996), , Volume: 126, Issue:7, 2019
Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease.Brain : a journal of neurology, , 08-01, Volume: 142, Issue:8, 2019
Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes.Nature neuroscience, , Volume: 22, Issue:7, 2019
Cerebrospinal fluid levels of alpha-synuclein measured using a poly-glutamic acid-modified gold nanoparticle-doped disposable neuro-biosensor system.The Analyst, , Jan-14, Volume: 144, Issue:2, 2019
A traffic jam leads to Lewy bodies.Nature neuroscience, , Volume: 22, Issue:7, 2019
Axonal pathology in hPSC-based models of Parkinson's disease results from loss of Nrf2 transcriptional activity at the Map1b gene locus.Proceedings of the National Academy of Sciences of the United States of America, , 07-09, Volume: 116, Issue:28, 2019
Selective inhibition of mitochondrial sodium-calcium exchanger protects striatal neurons from α-synuclein plus rotenone induced toxicity.Cell death & disease, , 01-28, Volume: 10, Issue:2, 2019
SNCA Rep1 promoter variability influences cognition in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:8, 2019
The prion-like spreading of α-synuclein: From in vitro to in vivo models of Parkinson's disease.Ageing research reviews, , Volume: 50, 2019
SNCA and mTOR Pathway Single Nucleotide Polymorphisms Interact to Modulate the Age at Onset of Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:9, 2019
GBA haploinsufficiency accelerates alpha-synuclein pathology with altered lipid metabolism in a prodromal model of Parkinson's disease.Human molecular genetics, , 06-01, Volume: 28, Issue:11, 2019
Interactions between iron and α-synuclein pathology in Parkinson's disease.Free radical biology & medicine, , Volume: 141, 2019
Detection of Parkinson's Disease through the Peptoid Recognizing α-Synuclein in Serum.ACS chemical neuroscience, , 03-20, Volume: 10, Issue:3, 2019
Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose.Scientific reports, , 01-24, Volume: 9, Issue:1, 2019
Serotonergic pathology and Braak's staging hypothesis in Parkinson's disease.The Lancet. Neurology, , Volume: 18, Issue:8, 2019
Regulatory Mechanism of miR-543-3p on GLT-1 in a Mouse Model of Parkinson's Disease.ACS chemical neuroscience, , 03-20, Volume: 10, Issue:3, 2019
The role of posttranslational modifications of α-synuclein and LRRK2 in Parkinson's disease: Potential contributions of environmental factors.Biochimica et biophysica acta. Molecular basis of disease, , 08-01, Volume: 1865, Issue:8, 2019
Histamine-4 receptor antagonist JNJ7777120 inhibits pro-inflammatory microglia and prevents the progression of Parkinson-like pathology and behaviour in a rat model.Brain, behavior, and immunity, , Volume: 76, 2019
Exosomes in Parkinson's Disease: Current Perspectives and Future Challenges.ACS chemical neuroscience, , 02-20, Volume: 10, Issue:2, 2019
High Selectivity and Sensitivity of Oligomeric p-Phenylene Ethynylenes for Detecting Fibrillar and Prefibrillar Amyloid Protein Aggregates.ACS chemical neuroscience, , 03-20, Volume: 10, Issue:3, 2019
Gut-brain axis and the spread of α-synuclein pathology: Vagal highway or dead end?Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:3, 2019
Colonic electrical stimulation improves colonic transit in rotenone-induced Parkinson's disease model through affecting enteric neurons.Life sciences, , Aug-15, Volume: 231, 2019
α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 01-29, Volume: 116, Issue:5, 2019
Down-regulation of natural resistance-associated macrophage protein-1 (Nramp1) is associated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)/1-methyl-4-phenylpyridinium (MPPNeuropathology and applied neurobiology, , Volume: 45, Issue:2, 2019
Extracellular Alpha-Synuclein Oligomers Induce Parkin S-Nitrosylation: Relevance to Sporadic Parkinson's Disease Etiopathology.Molecular neurobiology, , Volume: 56, Issue:1, 2019
The toxin MPTP generates similar cognitive and locomotor deficits in hTau and tau knock-out mice.Brain research, , 05-15, Volume: 1711, 2019
Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network.Stem cell reports, , 02-12, Volume: 12, Issue:2, 2019
Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease.Stem cell reports, , 02-12, Volume: 12, Issue:2, 2019
α-Synuclein and Glia in Parkinson's Disease: A Beneficial or a Detrimental Duet for the Endo-Lysosomal System?Cellular and molecular neurobiology, , Volume: 39, Issue:2, 2019
CSF Biomarkers for Early Diagnosis of Synucleinopathies: Focus on Idiopathic RBD.Current neurology and neuroscience reports, , 01-14, Volume: 19, Issue:2, 2019
Extracellular α-synuclein enters dopaminergic cells by modulating flotillin-1-assisted dopamine transporter endocytosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 33, Issue:9, 2019
Identification of N-linked glycans as specific mediators of neuronal uptake of acetylated α-Synuclein.PLoS biology, , Volume: 17, Issue:6, 2019
Randomized phase I clinical trial of anti-α-synuclein antibody BIIB054.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:8, 2019
[no title available]Annals of clinical and translational neurology, , Volume: 6, Issue:6, 2019
Association of the Polygenic Risk Score with the Incidence Risk of Parkinson's Disease and Cerebrospinal Fluid α-Synuclein in a Chinese Cohort.Neurotoxicity research, , Volume: 36, Issue:3, 2019
Gastrodin protects dopaminergic neurons via insulin-like pathway in a Parkinson's disease model.BMC neuroscience, , 06-17, Volume: 20, Issue:1, 2019
Exploring the Roles of Post-Translational Modifications in the Pathogenesis of Parkinson's Disease Using Synthetic and Semisynthetic Modified α-Synuclein.ACS chemical neuroscience, , 02-20, Volume: 10, Issue:2, 2019
Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo.Journal of visualized experiments : JoVE, , 06-02, Issue:148, 2019
α-Synuclein 2.0 - Moving towards Cell Type Specific Pathophysiology.Neuroscience, , 08-01, Volume: 412, 2019
Interrogating Parkinson's disease associated redox targets: Potential application of CRISPR editing.Free radical biology & medicine, , 11-20, Volume: 144, 2019
Oxidative stress in vagal neurons promotes parkinsonian pathology and intercellular α-synuclein transfer.The Journal of clinical investigation, , 06-13, Volume: 129, Issue:9, 2019
The effect of mutant GBA1 on accumulation and aggregation of α-synuclein.Human molecular genetics, , 06-01, Volume: 28, Issue:11, 2019
Disruptive membrane interactions of alpha-synuclein aggregates.Biochimica et biophysica acta. Proteins and proteomics, , Volume: 1867, Issue:5, 2019
Neuroprotective effects of Astilbin on MPTP-induced Parkinson's disease mice: Glial reaction, α-synuclein expression and oxidative stress.International immunopharmacology, , Volume: 66, 2019
Differential insular cortex subregional vulnerability to α-synuclein pathology in Parkinson's disease and dementia with Lewy bodies.Neuropathology and applied neurobiology, , Volume: 45, Issue:3, 2019
The early diagnosis of Parkinson's disease through combined biomarkers.Acta neurologica Scandinavica, , Volume: 140, Issue:4, 2019
Living in Promiscuity: The Multiple Partners of Alpha-Synuclein at the Synapse in Physiology and Pathology.International journal of molecular sciences, , Jan-02, Volume: 20, Issue:1, 2019
The Cell-Death-Associated Polymer PAR Feeds Forward α-Synuclein Toxicity in Parkinson's Disease.Molecular cell, , 01-03, Volume: 73, Issue:1, 2019
Ammon's Horn 2 (CA2) of the Hippocampus: A Long-Known Region with a New Potential Role in Neurodegeneration.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, , Volume: 25, Issue:2, 2019
Different Effects of α-Synuclein Mutants on Lipid Binding and Aggregation Detected by Single Molecule Fluorescence Spectroscopy and ThT Fluorescence-Based Measurements.ACS chemical neuroscience, , 03-20, Volume: 10, Issue:3, 2019
Treadmill exercise intervention improves gait and postural control in alpha-synuclein mouse models without inducing cerebral autophagy.Behavioural brain research, , 05-02, Volume: 363, 2019
Impairment of Nrf2- and Nitrergic-Mediated Gastrointestinal Motility in an MPTP Mouse Model of Parkinson's Disease.Digestive diseases and sciences, , Volume: 64, Issue:12, 2019
Systematically analyzing rare variants of autosomal-dominant genes for sporadic Parkinson's disease in a Chinese cohort.Neurobiology of aging, , Volume: 76, 2019
Immunoreactivity of a G protein-coupled l-DOPA receptor GPR143, in Lewy bodies.Neuroscience research, , Volume: 148, 2019
Patient-specific pluripotent stem cell-based Parkinson's disease models showing endogenous alpha-synuclein aggregation.BMB reports, , Volume: 52, Issue:6, 2019
Degeneration of dopaminergic circuitry influences depressive symptoms in Lewy body disorders.Brain pathology (Zurich, Switzerland), , Volume: 29, Issue:4, 2019
Aldehyde adducts inhibit 3,4-dihydroxyphenylacetaldehyde-induced α-synuclein aggregation and toxicity: Implication for Parkinson neuroprotective therapy.European journal of pharmacology, , Feb-15, Volume: 845, 2019
Gold nanoclusters for Parkinson's disease treatment.Biomaterials, , Volume: 194, 2019
Lycopodium Attenuates Loss of Dopaminergic Neurons by Suppressing Oxidative Stress and Neuroinflammation in a Rat Model of Parkinson's Disease.Molecules (Basel, Switzerland), , Jun-10, Volume: 24, Issue:11, 2019
Ubiquitin specific protease-13 independently regulates parkin ubiquitination and alpha-synuclein clearance in alpha-synucleinopathies.Human molecular genetics, , 02-15, Volume: 28, Issue:4, 2019
Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer's and Parkinson disease pathology.Biochimica et biophysica acta. Molecular basis of disease, , 08-01, Volume: 1865, Issue:8, 2019
Skin Fibroblasts as the Object for Clinical Diagnosis of Parkinson's Disease in Persons of Different Ages.Bulletin of experimental biology and medicine, , Volume: 167, Issue:1, 2019
Hinokitiol Offers Neuroprotection Against 6-OHDA-Induced Toxicity in SH-SY5Y Neuroblastoma Cells by Downregulating mRNA Expression of MAO/α-Synuclein/LRRK2/PARK7/PINK1/PTEN Genes.Neurotoxicity research, , Volume: 35, Issue:4, 2019
Effect of Genistein on the Transgenic Journal of dietary supplements, , Volume: 16, Issue:5, 2019
GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson's Disease.Scientific reports, , 06-10, Volume: 9, Issue:1, 2019
Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery.Cells, , 06-09, Volume: 8, Issue:6, 2019
Dynamic Properties of Human α-Synuclein Related to Propensity to Amyloid Fibril Formation.Journal of molecular biology, , 08-09, Volume: 431, Issue:17, 2019
Iron-related nigral degeneration influences functional topology mediated by striatal dysfunction in Parkinson's disease.Neurobiology of aging, , Volume: 75, 2019
Salidroside protects SH‑SY5Y from pathogenic α‑synuclein by promoting cell autophagy via mediation of mTOR/p70S6K signaling.Molecular medicine reports, , Volume: 20, Issue:1, 2019
Anti-Parkinson activity of bioactive substances extracted from Holothuria leucospilota.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 109, 2019
A secret that underlies Parkinson's disease: The damaging cycle.Neurochemistry international, , Volume: 129, 2019
TLR4 absence reduces neuroinflammation and inflammasome activation in Parkinson's diseases in vivo model.Brain, behavior, and immunity, , Volume: 76, 2019
α-Synuclein pathology in Parkinson's disease and related α-synucleinopathies.Neuroscience letters, , 09-14, Volume: 709, 2019
A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body-like pathology.Science translational medicine, , 06-05, Volume: 11, Issue:495, 2019
Lack of central and peripheral nervous system synuclein pathology in R1441G Journal of neurology, neurosurgery, and psychiatry, , Volume: 90, Issue:7, 2019
Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders.Annals of neurology, , Volume: 85, Issue:2, 2019
Alpha-synuclein at the nexus of genes and environment: the impact of environmental enrichment and stress on brain health and disease.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Downregulation of tyrosine hydroxylase phenotype after AAV injection above substantia nigra: Caution in experimental models of Parkinson's disease.Journal of neuroscience research, , Volume: 97, Issue:3, 2019
Disease model organism for Parkinson disease: Drosophila melanogaster.BMB reports, , Volume: 52, Issue:4, 2019
Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model.Acta neuropathologica, , Volume: 138, Issue:4, 2019
Cerebrospinal fluid biomarker for Parkinson's disease: An overview.Molecular and cellular neurosciences, , Volume: 97, 2019
Parkinson's disease: a short story of 200 years.Histology and histopathology, , Volume: 34, Issue:6, 2019
Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson's disease.BMC neurology, , Jun-04, Volume: 19, Issue:1, 2019
Spreading of alpha-synuclein - relevant or epiphenomenon?Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Naturally occurring autoantibodies against α-synuclein rescues memory and motor deficits and attenuates α-synuclein pathology in mouse model of Parkinson's disease.Neurobiology of disease, , Volume: 124, 2019
Effects of Exercise and Ferulic Acid on Alpha Synuclein and Neuroprotective Heat Shock Protein 70 in An Experimental Model of Parkinsonism Disease.CNS & neurological disorders drug targets, , Volume: 18, Issue:2, 2019
Pharmacological targeting of α-synuclein and TPPP/p25 in Parkinson's disease: challenges and opportunities in a Nutshell.FEBS letters, , Volume: 593, Issue:13, 2019
The issue of waste disposal in Parkinson's disease pathogenesis.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:7, 2019
Defining α-synuclein species responsible for Parkinson's disease phenotypes in mice.The Journal of biological chemistry, , 07-05, Volume: 294, Issue:27, 2019
Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid - method comparison and round robin study.Journal of neurochemistry, , Volume: 149, Issue:1, 2019
Heterogeneity in gut microbiota drive polyphenol metabolism that influences α-synuclein misfolding and toxicity.The Journal of nutritional biochemistry, , Volume: 64, 2019
Nitroalkylation of α-Synuclein by Nitro-Oleic Acid: Implications for Parkinson's Disease.Advances in experimental medicine and biology, , Volume: 1127, 2019
Interaction of α-Synuclein with ATP Synthase: Switching Role from Physiological to Pathological.ACS chemical neuroscience, , 01-16, Volume: 10, Issue:1, 2019
Peripheral mitochondrial function correlates with clinical severity in idiopathic Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:8, 2019
Biochemical and morphological classification of disease-associated alpha-synuclein mutants aggregates.Biochemical and biophysical research communications, , 01-15, Volume: 508, Issue:3, 2019
Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.Molecular cell, , 03-07, Volume: 73, Issue:5, 2019
Parafoveal thinning of inner retina is associated with visual dysfunction in Lewy body diseases.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:9, 2019
Establishing a framework for neuropathological correlates and glymphatic system functioning in Parkinson's disease.Neuroscience and biobehavioral reviews, , Volume: 103, 2019
Synaptic, Mitochondrial, and Lysosomal Dysfunction in Parkinson's Disease.Trends in neurosciences, , Volume: 42, Issue:2, 2019
Alpha-Synuclein Nitration and Its Implications in Parkinson's Disease.ACS chemical neuroscience, , 02-20, Volume: 10, Issue:2, 2019
Revisiting the History of the 1997 Alpha-Synuclein Discovery in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 9, Issue:2, 2019
Low-Dose Aspirin Upregulates Tyrosine Hydroxylase and Increases Dopamine Production in Dopaminergic Neurons: Implications for Parkinson's Disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 14, Issue:2, 2019
Letter to the Editor.Journal of Parkinson's disease, , Volume: 9, Issue:2, 2019
Accelerated accumulation of retinal α-synuclein (pSer129) and tau, neuroinflammation, and autophagic dysregulation in a seeded mouse model of Parkinson's disease.Neurobiology of disease, , Volume: 121, 2019
Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein.Human molecular genetics, , 01-01, Volume: 28, Issue:1, 2019
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis.Acta neuropathologica, , Volume: 137, Issue:1, 2019
Evaluation of Carnosine Intervention in the Thy1-aSyn Mouse Model of Parkinson's Disease.Neuroscience, , 07-15, Volume: 411, 2019
CSF β-amyloidNeurology, , 01-01, Volume: 92, Issue:1, 2019
Path mediation analysis reveals GBA impacts Lewy body disease status by increasing α-synuclein levels.Neurobiology of disease, , Volume: 121, 2019
Skin nerve α-synuclein deposits in a parkinsonian patient with heterozygous parkin mutation.Parkinsonism & related disorders, , Volume: 60, 2019
Age-dependent nigral dopaminergic neurodegeneration and α-synuclein accumulation in RGS6-deficient mice.JCI insight, , 05-23, Volume: 5, 2019
Association of SNCA variants with α-synuclein of gastric and colonic mucosa in Parkinson's disease.Parkinsonism & related disorders, , Volume: 61, 2019
In-vitro and in-silico investigation of protective mechanisms of crocin against E46K α-synuclein amyloid formation.Molecular biology reports, , Volume: 46, Issue:4, 2019
Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson's disease.Scientific reports, , 05-21, Volume: 9, Issue:1, 2019
Colonic neuropathology is not associated with autonomic dysfunction in Parkinson's disease.Parkinsonism & related disorders, , Volume: 61, 2019
Understanding multifactorial architecture of Parkinson's disease: pathophysiology to management.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 40, Issue:1, 2019
TIGAR inclusion pathology is specific for Lewy body diseases.Brain research, , 03-01, Volume: 1706, 2019
Genetic variants of PARK genes in Korean patients with early-onset Parkinson's disease.Neurobiology of aging, , Volume: 75, 2019
The unlikely partnership between LRRK2 and α-synuclein in Parkinson's disease.The European journal of neuroscience, , Volume: 49, Issue:3, 2019
Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson's disease.Journal of neuroinflammation, , Jul-22, Volume: 16, Issue:1, 2019
Alpha-synuclein structure and Parkinson's disease - lessons and emerging principles.Molecular neurodegeneration, , 07-22, Volume: 14, Issue:1, 2019
Modeling Parkinson's disease in adult Drosophila.Journal of neuroscience methods, , 01-01, Volume: 311, 2019
Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease.Annals of neurology, , Volume: 86, Issue:4, 2019
New therapeutic approaches to target alpha-synuclein in Parkinson's disease: The role of immunotherapy.International review of neurobiology, , Volume: 146, 2019
Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders.Scientific reports, , 07-29, Volume: 9, Issue:1, 2019
Regional transcriptional architecture of Parkinson's disease pathogenesis and network spread.Brain : a journal of neurology, , 10-01, Volume: 142, Issue:10, 2019
Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils.Neurobiology of disease, , Volume: 129, 2019
Longitudinal analyses of cerebrospinal fluid α-Synuclein in prodromal and early Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:9, 2019
5-S-cysteinyl-dopamine, a neurotoxic endogenous metabolite of dopamine: Implications for Parkinson's disease.Neurochemistry international, , Volume: 129, 2019
Iron and other metals in the pathogenesis of Parkinson's disease: Toxic effects and possible detoxification.Journal of inorganic biochemistry, , Volume: 199, 2019
Central Nervous System-Derived Exosomal Alpha-Synuclein in Serum May Be a Biomarker in Parkinson's Disease.Neuroscience, , 08-10, Volume: 413, 2019
TREM2 deficiency aggravates α-synuclein-induced neurodegeneration and neuroinflammation in Parkinson's disease models.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 33, Issue:11, 2019
Precision Medicine in Rapid Eye Movement Sleep Behavior Disorder.Sleep medicine clinics, , Volume: 14, Issue:3, 2019
Autophagy activation promotes clearance of α-synuclein inclusions in fibril-seeded human neural cells.The Journal of biological chemistry, , 09-27, Volume: 294, Issue:39, 2019
Effects of single and combined immunotherapy approach targeting amyloid β protein and α-synuclein in a dementia with Lewy bodies-like model.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 15, Issue:9, 2019
Alpha-synuclein gene polymorphism affects risk of dementia in Han Chinese with Parkinson's disease.Neuroscience letters, , 07-27, Volume: 706, 2019
Oxidative stress and α-synuclein conspire in vulnerable neurons to promote Parkinson's disease progression.The Journal of clinical investigation, , 08-05, Volume: 129, Issue:9, 2019
Deciphering the anti-Parkinson's activity of sulphated polysaccharides from Chlamydomonas reinhardtii on the α-Synuclein mutants A30P, A53T, E46K, E57K and E35K.Journal of biochemistry, , Dec-01, Volume: 166, Issue:6, 2019
A Cleaning Crew: The Pursuit of Autophagy in Parkinson's Disease.ACS chemical neuroscience, , 09-18, Volume: 10, Issue:9, 2019
Effects of alpha-synuclein post-translational modifications on metal binding.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Membrane interactions of intrinsically disordered proteins: The example of alpha-synuclein.Biochimica et biophysica acta. Proteins and proteomics, , Volume: 1867, Issue:10, 2019
C-terminal α-synuclein truncations are linked to cysteine cathepsin activity in Parkinson's disease.The Journal of biological chemistry, , 06-21, Volume: 294, Issue:25, 2019
Preclinical signs of Parkinson's disease: A possible association of Parkinson's disease with skin and hair features.Medical hypotheses, , Volume: 127, 2019
LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?Biochemical Society transactions, , 06-28, Volume: 47, Issue:3, 2019
Assessment of risk factor variants of LRRK2, MAPT, SNCA and TCEANC2 genes in Hungarian sporadic Parkinson's disease patients.Neuroscience letters, , 07-27, Volume: 706, 2019
Identifying the Pathological Domain of Alpha- Synuclein as a Therapeutic for Parkinson's Disease.International journal of molecular sciences, , May-11, Volume: 20, Issue:9, 2019
Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification.Neurobiology of disease, , Volume: 129, 2019
Dystonia and Parkinson's disease: What is the relationship?Neurobiology of disease, , Volume: 132, 2019
Layer-specific axonal degeneration of serotonergic fibers in the prefrontal cortex of aged A53T α-synuclein-expressing mice.Neurobiology of aging, , Volume: 80, 2019
Submandibular gland is a suitable site for alpha synuclein pathology in Parkinson disease.Parkinsonism & related disorders, , Volume: 58, 2019
The Toxicity of Misfolded Protein Oligomers Is Independent of Their Secondary Structure.ACS chemical biology, , 07-19, Volume: 14, Issue:7, 2019
Vitamin B12 inhibits α-synuclein fibrillogenesis and protects against amyloid-induced cytotoxicity.Food & function, , May-22, Volume: 10, Issue:5, 2019
How is alpha-synuclein cleared from the cell?Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Temporal evolution of microglia and α-synuclein accumulation following foetal grafting in Parkinson's disease.Brain : a journal of neurology, , 06-01, Volume: 142, Issue:6, 2019
Antibodies against alpha-synuclein: tools and therapies.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Progress of immunotherapy of anti-α-synuclein in Parkinson's disease.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 115, 2019
Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies.ACS chemical biology, , 06-21, Volume: 14, Issue:6, 2019
SNCA but not DNM3 and GAK modifies age at onset of LRRK2-related Parkinson's disease in Chinese population.Journal of neurology, , Volume: 266, Issue:7, 2019
Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia.The Journal of experimental medicine, , 06-03, Volume: 216, Issue:6, 2019
Parkinson's disease and multiple system atrophy have distinct α-synuclein seed characteristics.The Journal of biological chemistry, , 01-18, Volume: 294, Issue:3, 2019
Alpha-Synuclein Is a Target of Fic-Mediated Adenylylation/AMPylation: Possible Implications for Parkinson's Disease.Journal of molecular biology, , 05-31, Volume: 431, Issue:12, 2019
Viral mimetic priming enhances α-synuclein-induced degeneration: Implications for Parkinson's disease.Brain, behavior, and immunity, , Volume: 80, 2019
Triggers, Facilitators, and Aggravators: Redefining Parkinson's Disease Pathogenesis.Trends in neurosciences, , Volume: 42, Issue:1, 2019
Cerebral mitochondrial electron transport chain dysfunction in multiple system atrophy and Parkinson's disease.Scientific reports, , 04-25, Volume: 9, Issue:1, 2019
Hippocampal CA2 Lewy pathology is associated with cholinergic degeneration in Parkinson's disease with cognitive decline.Acta neuropathologica communications, , 04-25, Volume: 7, Issue:1, 2019
Necrosis, apoptosis, necroptosis, three modes of action of dopaminergic neuron neurotoxins.PloS one, , Volume: 14, Issue:4, 2019
Baseline concentration of misfolded α-synuclein aggregates in cerebrospinal fluid predicts risk of cognitive decline in Parkinson's disease.Neuropathology and applied neurobiology, , Volume: 45, Issue:4, 2019
A Comparative Study of the Diagnostic Potential of Plasma and Erythrocytic α-Synuclein in Parkinson's Disease.Neuro-degenerative diseases, , Volume: 19, Issue:5-6, 2019
Phosphorylated NUB1 distinguishes α-synuclein in Lewy bodies from that in glial cytoplasmic inclusions in multiple system atrophy.Brain pathology (Zurich, Switzerland), , Volume: 29, Issue:6, 2019
CSF α-synuclein inversely correlates with non-motor symptoms in a cohort of PD patients.Parkinsonism & related disorders, , Volume: 61, 2019
Associations Between APOE Variants, Tau and α-Synuclein.Advances in experimental medicine and biology, , Volume: 1184, 2019
Role of Parkinson's Disease-Linked Mutations and N-Terminal Acetylation on the Oligomerization of α-Synuclein Induced by 3,4-Dihydroxyphenylacetaldehyde.ACS chemical neuroscience, , 01-16, Volume: 10, Issue:1, 2019
Gene co-expression analysis of the human substantia nigra identifies BMP2 as a neurotrophic factor that can promote neurite growth in cells overexpressing wild-type or A53T α-synuclein.Parkinsonism & related disorders, , Volume: 64, 2019
Mathematical Biology Models of Parkinson's Disease.CPT: pharmacometrics & systems pharmacology, , Volume: 8, Issue:2, 2019
Quantitative Characterization of α-Synuclein Aggregation in Living Cells through Automated Microfluidics Feedback Control.Cell reports, , 04-16, Volume: 27, Issue:3, 2019
In Vivo Phenotyping of Familial Parkinson's Disease with Human Induced Pluripotent Stem Cells: A Proof-of-Concept Study.Neurochemical research, , Volume: 44, Issue:6, 2019
AAV2/DJ-mediated alpha-synuclein overexpression in the rat substantia nigra as early stage model of Parkinson's disease.Cell and tissue research, , Volume: 378, Issue:1, 2019
Expression of α-synuclein is regulated in a neuronal cell type-dependent manner.Anatomical science international, , Volume: 94, Issue:1, 2019
Targeting alpha synuclein and amyloid beta by a multifunctional, brain-penetrant dopamine D2/D3 agonist D-520: Potential therapeutic application in Parkinson's disease with dementia.Scientific reports, , 12-23, Volume: 9, Issue:1, 2019
Neurodegeneration and contralateral α-synuclein induction after intracerebral α-synuclein injections in the anterior olfactory nucleus of a Parkinson's disease A53T mouse model.Acta neuropathologica communications, , 04-15, Volume: 7, Issue:1, 2019
Investigation of somatic CNVs in brains of synucleinopathy cases using targeted SNCA analysis and single cell sequencing.Acta neuropathologica communications, , 12-23, Volume: 7, Issue:1, 2019
Parkinson's disease recovery by GM1 oligosaccharide treatment in the B4galnt1Scientific reports, , 12-18, Volume: 9, Issue:1, 2019
CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson's disease.Journal of neuroinflammation, , Dec-12, Volume: 16, Issue:1, 2019
Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy.eLife, , 12-09, Volume: 8, 2019
Common genetic variants associated with Parkinson's disease display widespread signature of epigenetic plasticity.Scientific reports, , 12-05, Volume: 9, Issue:1, 2019
LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson's disease patients.Nature communications, , 12-05, Volume: 10, Issue:1, 2019
Targeting α-Synuclein in Parkinson's Disease: Progress Towards the Development of Disease-Modifying Therapeutics.Drugs, , Volume: 79, Issue:8, 2019
Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a Communications biology, , Volume: 2, 2019
Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts.Nature communications, , 12-04, Volume: 10, Issue:1, 2019
Luminescent conjugated oligothiophenes distinguish between α-synuclein assemblies of Parkinson's disease and multiple system atrophy.Acta neuropathologica communications, , 12-03, Volume: 7, Issue:1, 2019
[Electroacupuncture improved locomotor function by regulating expression of tyrosine hydroxylase and α-synuclein proteins and transcription activating factor 6 and transcription factor X box binding protein 1 mRNAs in substantia nigra of rats with ParkinsZhen ci yan jiu = Acupuncture research, , Nov-25, Volume: 44, Issue:11, 2019
In Vivo Protein Complementation Demonstrates Presynaptic α-Synuclein Oligomerization and Age-Dependent Accumulation of 8-16-mer Oligomer Species.Cell reports, , Nov-26, Volume: 29, Issue:9, 2019
α-Synuclein toxicity in yeast and human cells is caused by cell cycle re-entry and autophagy degradation of ribonucleotide reductase 1.Aging cell, , Volume: 18, Issue:4, 2019
Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease.Scientific reports, , 11-22, Volume: 9, Issue:1, 2019
Binding of α-synuclein oligomers to Cx32 facilitates protein uptake and transfer in neurons and oligodendrocytes.Acta neuropathologica, , Volume: 138, Issue:1, 2019
Local vulnerability and global connectivity jointly shape neurodegenerative disease propagation.PLoS biology, , Volume: 17, Issue:11, 2019
The landscape of multiscale transcriptomic networks and key regulators in Parkinson's disease.Nature communications, , 11-20, Volume: 10, Issue:1, 2019
α-Synuclein in blood cells differentiates Parkinson's disease from healthy controls.Annals of clinical and translational neurology, , Volume: 6, Issue:12, 2019
Autophagic- and Lysosomal-Related Biomarkers for Parkinson's Disease: Lights and Shadows.Cells, , 10-25, Volume: 8, Issue:11, 2019
The Overcrowded Crossroads: Mitochondria, Alpha-Synuclein, and the Endo-Lysosomal System Interaction in Parkinson's Disease.International journal of molecular sciences, , Oct-25, Volume: 20, Issue:21, 2019
Mitochondrial damage by α-synuclein causes cell death in human dopaminergic neurons.Cell death & disease, , 11-14, Volume: 10, Issue:11, 2019
Neurotoxic and Neuroprotective Role of Exosomes in Parkinson's Disease.Current pharmaceutical design, , Volume: 25, Issue:42, 2019
[The Propagation Hypothesis of Prion-like Protein Agregates in Neurodegenerative Diseases].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 71, Issue:11, 2019
α-Synuclein Penetrates Mucin Hydrogels Despite Its Mucoadhesive Properties.Biomacromolecules, , 12-09, Volume: 20, Issue:12, 2019
A split-GFP tool reveals differences in the sub-mitochondrial distribution of wt and mutant alpha-synuclein.Cell death & disease, , 11-12, Volume: 10, Issue:11, 2019
Caffeic acid reduces A53T α-synuclein by activating JNK/Bcl-2-mediated autophagy in vitro and improves behaviour and protects dopaminergic neurons in a mouse model of Parkinson's disease.Pharmacological research, , Volume: 150, 2019
Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease.Molecular neurodegeneration, , 11-08, Volume: 14, Issue:1, 2019
Partially oxidized DJ-1 inhibits α-synuclein nucleation and remodels mature α-synuclein fibrils in vitro.Communications biology, , Volume: 2, 2019
Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs.Nature structural & molecular biology, , Volume: 26, Issue:11, 2019
Hsp110 mitigates α-synuclein pathology in vivo.Proceedings of the National Academy of Sciences of the United States of America, , 11-26, Volume: 116, Issue:48, 2019
ARSA variants in α-synucleinopathies.Brain : a journal of neurology, , 12-01, Volume: 142, Issue:12, 2019
Circulating amino acid signature in older people with Parkinson's disease: A metabolic complement to the EXosomes in PArkiNson Disease (EXPAND) study.Experimental gerontology, , Volume: 128, 2019
Intrastriatal injection of alpha-synuclein fibrils induces Parkinson-like pathology in macaques.Brain : a journal of neurology, , 11-01, Volume: 142, Issue:11, 2019
Fatty Acid-Binding Protein 3 is Critical for α-Synuclein Uptake and MPPInternational journal of molecular sciences, , Oct-28, Volume: 20, Issue:21, 2019
SERF engages in a fuzzy complex that accelerates primary nucleation of amyloid proteins.Proceedings of the National Academy of Sciences of the United States of America, , 11-12, Volume: 116, Issue:46, 2019
Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies.Cells, , 10-10, Volume: 8, Issue:10, 2019
Redox active metals in neurodegenerative diseases.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, , Volume: 24, Issue:8, 2019
Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein.Neuron, , 12-04, Volume: 104, Issue:5, 2019
[Research progress on neural mechanism of peripheral inflammation in Parkinson's disease].Sheng li xue bao : [Acta physiologica Sinica], , Oct-25, Volume: 71, Issue:5, 2019
Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior.Cell reports, , 10-22, Volume: 29, Issue:4, 2019
IRE1 promotes neurodegeneration through autophagy-dependent neuron death in the Drosophila model of Parkinson's disease.Cell death & disease, , 10-22, Volume: 10, Issue:11, 2019
Chronic nigral neuromodulation aggravates behavioral deficits and synaptic changes in an α-synuclein based rat model for Parkinson's disease.Acta neuropathologica communications, , 10-22, Volume: 7, Issue:1, 2019
Alpha-synuclein stepwise aggregation reveals features of an early onset mutation in Parkinson's disease.Communications biology, , Volume: 2, 2019
Electrochemical biosensors for the detection and study of α-synuclein related to Parkinson's disease - A review.Analytica chimica acta, , Dec-16, Volume: 1089, 2019
Feasibility of repeat and bilateral submandibular gland needle biopsies in Parkinson's disease.Parkinsonism & related disorders, , Volume: 68, 2019
Clinical variability in Chinese families with Parkinson disease and SNCA duplication, including the shortest 139kb duplication.Parkinsonism & related disorders, , Volume: 68, 2019
Neuronal exosomes in saliva of Parkinson's disease patients: A pilot study.Parkinsonism & related disorders, , Volume: 67, 2019
Distinct Autoimmune Anti-α-Synuclein Antibody Patterns in Multiple System Atrophy and Parkinson's Disease.Frontiers in immunology, , Volume: 10, 2019
The Appendix in Parkinson's Disease: From Vestigial Remnant to Vital Organ?Journal of Parkinson's disease, , Volume: 9, Issue:s2, 2019
Stabilization of α-synuclein oligomers using formaldehyde.PloS one, , Volume: 14, Issue:10, 2019
Lower nucleus accumbens α-synuclein load and D3 receptor levels in Parkinson's disease with impulsive compulsive behaviours.Brain : a journal of neurology, , 11-01, Volume: 142, Issue:11, 2019
From Yeast to Humans: Leveraging New Approaches in Yeast to Accelerate Discovery of Therapeutic Targets for Synucleinopathies.Methods in molecular biology (Clifton, N.J.), , Volume: 2049, 2019
Calpain in the cleavage of alpha-synuclein and the pathogenesis of Parkinson's disease.Progress in molecular biology and translational science, , Volume: 167, 2019
Mutations in CHCHD2 cause α-synuclein aggregation.Human molecular genetics, , 12-01, Volume: 28, Issue:23, 2019
Interaction between Copper Chaperone Atox1 and Parkinson's Disease Protein α-Synuclein Includes Metal-Binding Sites and Occurs in Living Cells.ACS chemical neuroscience, , 11-20, Volume: 10, Issue:11, 2019
Gastrointestinal Immunity and Alpha-Synuclein.Journal of Parkinson's disease, , Volume: 9, Issue:s2, 2019
The interplay between parkin and alpha-synuclein; possible implications for the pathogenesis of Parkinson's disease.Acta neurobiologiae experimentalis, , Volume: 79, Issue:3, 2019
Parkinson's disease: How do highly toxic α-Synuclein/PAR aggregates mediate neuronal cell death?Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:5, 2019
Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology.Neurobiology of aging, , Volume: 83, 2019
Microglia in Parkinson's Disease.Advances in experimental medicine and biology, , Volume: 1175, 2019
Levels of oligomeric α-Synuclein in reflex tears distinguish Parkinson's disease patients from healthy controls.Biomarkers in medicine, , Volume: 13, Issue:17, 2019
Parkinson's disease-associated Proceedings of the National Academy of Sciences of the United States of America, , 10-08, Volume: 116, Issue:41, 2019
miR-let-7a suppresses α-Synuclein-induced microglia inflammation through targeting STAT3 in Parkinson's disease.Biochemical and biophysical research communications, , 11-19, Volume: 519, Issue:4, 2019
Clinical Reasoning: A 58-year-old man with hand tremor and episodes of neck pain.Neurology, , 09-17, Volume: 93, Issue:12, 2019
Silver staining (Campbell-Switzer) of neuronal α-synuclein assemblies induced by multiple system atrophy and Parkinson's disease brain extracts in transgenic mice.Acta neuropathologica communications, , 09-16, Volume: 7, Issue:1, 2019
Proteomics-Based Monitoring of Pathway Activity Reveals that Blocking Diacylglycerol Biosynthesis Rescues from Alpha-Synuclein Toxicity.Cell systems, , 09-25, Volume: 9, Issue:3, 2019
Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology.Molecular therapy : the journal of the American Society of Gene Therapy, , 12-04, Volume: 27, Issue:12, 2019
Brain-First versus Gut-First Parkinson's Disease: A Hypothesis.Journal of Parkinson's disease, , Volume: 9, Issue:s2, 2019
Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson's disease.Nature communications, , 09-02, Volume: 10, Issue:1, 2019
Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:6, 2019
Lots of Movement in Gut and Parkinson's Research.Trends in endocrinology and metabolism: TEM, , Volume: 30, Issue:10, 2019
Iron Pathophysiology in Parkinson Diseases.Advances in experimental medicine and biology, , Volume: 1173, 2019
Alterations in Blood Monocyte Functions in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:11, 2019
Seeding of protein aggregation causes cognitive impairment in rat model of cortical synucleinopathy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:11, 2019
High lithium levels in tobacco may account for reduced incidences of both Parkinson's disease and melanoma in smokers through enhanced β-catenin-mediated activity.Medical hypotheses, , Volume: 131, 2019
Synuclein Meeting 2019: where we are and where we need to go.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Effect of naturally occurring α-synuclein-antibodies on toxic α-synuclein-fragments.Neuroscience letters, , 06-21, Volume: 704, 2019
Exploring the Peripheral Initiation of Parkinson's Disease in Animal Models.Neuron, , 08-21, Volume: 103, Issue:4, 2019
Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies.JCI insight, , 08-22, Volume: 4, Issue:16, 2019
Deployment of Label-Free Quantitative Olfactory Proteomics to Detect Cerebrospinal Fluid Biomarker Candidates in Synucleinopathies.Methods in molecular biology (Clifton, N.J.), , Volume: 2044, 2019
Roles for the adaptive immune system in Parkinson's and Alzheimer's diseases.Current opinion in immunology, , Volume: 59, 2019
Parkinson's disease is a type of amyloidosis featuring accumulation of amyloid fibrils of α-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , 09-03, Volume: 116, Issue:36, 2019
N-Terminal Acetylation Affects α-Synuclein Fibril Polymorphism.Biochemistry, , 09-03, Volume: 58, Issue:35, 2019
Neuroprotective and Neurotherapeutic Effects of Tetrahedral Framework Nucleic Acids on Parkinson's Disease ACS applied materials & interfaces, , Sep-11, Volume: 11, Issue:36, 2019
Low prevalence of known pathogenic mutations in dominant PD genes: A Swedish multicenter study.Parkinsonism & related disorders, , Volume: 66, 2019
Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson's disease.Molecular neurodegeneration, , 08-16, Volume: 14, Issue:1, 2019
Complex of EGCG with Cu(II) Suppresses Amyloid Aggregation and Cu(II)-Induced Cytotoxicity of α-Synuclein.Molecules (Basel, Switzerland), , Aug-14, Volume: 24, Issue:16, 2019
Calling α-synuclein a prion is scientifically justifiable.Acta neuropathologica, , Volume: 138, Issue:4, 2019
Nitrated alpha-synuclein in minor salivary gland biopsies in Parkinson's disease.Neuroscience letters, , 06-21, Volume: 704, 2019
Spinal cord α-synuclein deposition associated with myoclonus in patients with MSA-C.Neurology, , 08-13, Volume: 93, Issue:7, 2019
Mass Spectrometric Analysis of Lewy Body-Enriched α-Synuclein in Parkinson's Disease.Journal of proteome research, , 05-03, Volume: 18, Issue:5, 2019
Extracellular microvesicles-derived from microglia treated with unaggregated α-synuclein attenuate mitochondrial fission and toxicity-induced by Parkinsonian toxin MPPBiochemical and biophysical research communications, , 10-01, Volume: 517, Issue:4, 2019
Salivary alpha-synuclein as a biomarker for Parkinson's disease: a systematic review.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 126, Issue:11, 2019
The effects of acupuncture and electroacupuncture on Parkinson's disease: Current status and future perspectives for molecular mechanisms.Journal of cellular biochemistry, , Volume: 120, Issue:8, 2019
Loss of One Engrailed1 Allele Enhances Induced α-Synucleinopathy.Journal of Parkinson's disease, , Volume: 9, Issue:2, 2019
[Differential diagnosis of RBD symptomatology (idiopathic RBD or RBD mimics)].Rinsho shinkeigaku = Clinical neurology, , Apr-25, Volume: 59, Issue:4, 2019
LRRK2 modifies α-syn pathology and spread in mouse models and human neurons.Acta neuropathologica, , Volume: 137, Issue:6, 2019
Recapitulating Parkinson's disease pathology in a three-dimensional human neural cell culture model.Disease models & mechanisms, , 04-09, Volume: 12, Issue:4, 2019
Increased α-synuclein levels in patients with sleep apnoea might be involved in PD pathogenesis.Nature reviews. Neurology, , Volume: 15, Issue:5, 2019
Binding of Noradrenaline to Native and Intermediate States during the Fibrillation of α-Synuclein Leads to the Formation of Stable and Structured Cytotoxic Species.ACS chemical neuroscience, , 06-19, Volume: 10, Issue:6, 2019
Apelin-13 protects dopaminergic neurons in MPTP-induced Parkinson's disease model mice through inhibiting endoplasmic reticulum stress and promoting autophagy.Brain research, , 07-15, Volume: 1715, 2019
Plasma alpha-synuclein detected by single molecule array is increased in PD.Annals of clinical and translational neurology, , Volume: 6, Issue:3, 2019
Sex Differences in Rotenone Sensitivity Reflect the Male-to-Female Ratio in Human Parkinson's Disease Incidence.Toxicological sciences : an official journal of the Society of Toxicology, , 07-01, Volume: 170, Issue:1, 2019
Pharmacokinetics and pharmacodynamics of a single dose Nilotinib in individuals with Parkinson's disease.Pharmacology research & perspectives, , Volume: 7, Issue:2, 2019
The aggregation state of α-synuclein deposits in dermal nerve fibers of patients with Parkinson's disease resembles that in the brain.Parkinsonism & related disorders, , Volume: 64, 2019
Two conformationally distinct α-synuclein oligomers share common epitopes and the ability to impair long-term potentiation.PloS one, , Volume: 14, Issue:3, 2019
Dihydromyricetin Inhibits α-Synuclein Aggregation, Disrupts Preformed Fibrils, and Protects Neuronal Cells in Culture against Amyloid-Induced Cytotoxicity.Journal of agricultural and food chemistry, , Apr-10, Volume: 67, Issue:14, 2019
Clinical and neuropathological differences between Parkinson's disease, Parkinson's disease dementia and dementia with Lewy bodies - current issues and future directions.Journal of neurochemistry, , Volume: 150, Issue:5, 2019
Label-free detection of early oligomerization of α-synuclein and its mutants A30P/E46K through solid-state nanopores.Nanoscale, , Mar-28, Volume: 11, Issue:13, 2019
Unbalanced calcium channel activity underlies selective vulnerability of nigrostriatal dopaminergic terminals in Parkinsonian mice.Scientific reports, , 03-19, Volume: 9, Issue:1, 2019
Engineering synucleinopathy-resistant human dopaminergic neurons by CRISPR-mediated deletion of the SNCA gene.The European journal of neuroscience, , Volume: 49, Issue:4, 2019
Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity.Acta neuropathologica, , Volume: 137, Issue:6, 2019
Microbiome, Parkinson's Disease and Molecular Mimicry.Cells, , 03-07, Volume: 8, Issue:3, 2019
Autoimmunity in Parkinson's Disease: The Role of α-Synuclein-Specific T Cells.Frontiers in immunology, , Volume: 10, 2019
α-Synuclein misfolding and aggregation: Implications in Parkinson's disease pathogenesis.Biochimica et biophysica acta. Proteins and proteomics, , Volume: 1867, Issue:10, 2019
Extreme sleep pattern in Lewy body dementia: a hypothalamic matter?BMJ case reports, , Mar-09, Volume: 12, Issue:3, 2019
Predictive model of spread of Parkinson's pathology using network diffusion.NeuroImage, , 05-15, Volume: 192, 2019
Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis.Nature communications, , 03-07, Volume: 10, Issue:1, 2019
Parkinson's disease-linked Proceedings of the National Academy of Sciences of the United States of America, , 03-19, Volume: 116, Issue:12, 2019
An attempt to elucidate the role of iron and zinc ions in development of Alzheimer's and Parkinson's diseases.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 111, 2019
Comparative study of cerebrospinal fluid α-synuclein seeding aggregation assays for diagnosis of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:4, 2019
Anti-ageing and anti-Parkinsonian effects of natural flavonol, tambulin from Zanthoxyllum aramatum promotes longevity in Caenorhabditis elegans.Experimental gerontology, , Volume: 120, 2019
Cyclized NDGA modifies dynamic α-synuclein monomers preventing aggregation and toxicity.Scientific reports, , 02-27, Volume: 9, Issue:1, 2019
Endosomal trafficking leads the way in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:4, 2019
Another Brick in the Wall.Journal of innate immunity, , Volume: 11, Issue:2, 2019
LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice.Acta neuropathologica communications, , 02-26, Volume: 7, Issue:1, 2019
Dopamine Cytotoxicity on SH-SY5Y Cells: Involvement of α-Synuclein and Relevance in the Neurodegeneration of Sporadic Parkinson's Disease.Neurotoxicity research, , Volume: 35, Issue:4, 2019
Naturally occurring antibodies isolated from PD patients inhibit synuclein seeding in vitro and recognize Lewy pathology.Acta neuropathologica, , Volume: 137, Issue:5, 2019
Diagnostic utility of gut α-synuclein in Parkinson's disease: A systematic review and meta-analysis.Behavioural brain research, , 05-17, Volume: 364, 2019
The deglycase activity of DJ-1 mitigates α-synuclein glycation and aggregation in dopaminergic cells: Role of oxidative stress mediated downregulation of DJ-1 in Parkinson's disease.Free radical biology & medicine, , 05-01, Volume: 135, 2019
The heart of PD: Lewy body diseases as neurocardiologic disorders.Brain research, , 01-01, Volume: 1702, 2019
Switching on Endogenous Metal Binding Proteins in Parkinson's Disease.Cells, , 02-19, Volume: 8, Issue:2, 2019
SMPD1 mutations, activity, and α-synuclein accumulation in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 34, Issue:4, 2019
Microglia as modulators of exosomal alpha-synuclein transmission.Cell death & disease, , 02-20, Volume: 10, Issue:3, 2019
Hyperosmotic stress induces cell-dependent aggregation of α-synuclein.Scientific reports, , 02-19, Volume: 9, Issue:1, 2019
A PARP-1 Feed-Forward Mechanism To Accelerate α-Synuclein Toxicity in Parkinson's Disease.Biochemistry, , 02-19, Volume: 58, Issue:7, 2019
The primary neuronal cells are more resistant than PC12 cells to α-synuclein toxic aggregates.Neuroscience letters, , 05-14, Volume: 701, 2019
Polysomnographic data in Dementia with Lewy Bodies: correlation with clinical symptoms and comparison with other α-synucleinopathies.Sleep medicine, , Volume: 55, 2019
Alpha-synuclein in salivary gland as biomarker for Parkinson's disease.Reviews in the neurosciences, , 07-26, Volume: 30, Issue:5, 2019
Expression and Purification of Untagged α-Synuclein.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
In Situ Peroxidase Labeling and Mass Spectrometry of Alpha-Synuclein in Rat Cortical Neurons.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
Diagnostic biomarkers for Parkinson's disease: focus on α-synuclein in cerebrospinal fluid.Parkinsonism & related disorders, , Volume: 59, 2019
Detection of α-Synuclein in Biological Samples Using Mass Spectrometry.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
Monitoring α-Synuclein Proteotoxicity in Drosophila Models.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
Measuring Mitochondrial Dysfunction Caused by Soluble α-Synuclein Oligomers.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
Yeast-Based Screens to Target Alpha-Synuclein Toxicity.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
Studying α-Synuclein Conformation by Intact-Cell Cross-Linking.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
Alpha-Synuclein Proximity Ligation Assay (AS-PLA) in Brain Sections to Probe for Alpha-Synuclein Oligomers.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
Quantification of Alpha-Synuclein in Biological Fluids by Electrochemiluminescence-Based Detection.Methods in molecular biology (Clifton, N.J.), , Volume: 1948, 2019
Enteric Pathologic Manifestations of Alpha-Synucleinopathies.Applied immunohistochemistry & molecular morphology : AIMM, , Volume: 27, Issue:7, 2019
Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype.Autophagy, , Volume: 14, Issue:1, 2018
Suppression of autophagy in the brain of transgenic mice with overexpression of А53Т-mutant α-synuclein as an early event at synucleinopathy progression.Neuroscience letters, , 04-13, Volume: 672, 2018
LncRNA SNHG1 promotes α-synuclein aggregation and toxicity by targeting miR-15b-5p to activate SIAH1 in human neuroblastoma SH-SY5Y cells.Neurotoxicology, , Volume: 68, 2018
Alteration of autophagy-related proteins in peripheral blood mononuclear cells of patients with Parkinson's disease.Neurobiology of aging, , Volume: 63, 2018
Expression of the DJ-1 protein in the serum of Chinese patients with Parkinson's disease.Neuroscience letters, , 02-05, Volume: 665, 2018
Alpha-synuclein staining in non-neural structures of the gastrointestinal tract is non-specific in Parkinson disease.Parkinsonism & related disorders, , Volume: 55, 2018
Using Patient-Derived Induced Pluripotent Stem Cells to Identify Parkinson's Disease-Relevant Phenotypes.Current neurology and neuroscience reports, , 10-04, Volume: 18, Issue:12, 2018
Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons.Neurobiology of disease, , Volume: 111, 2018
FKBP12-immunopositive inclusions in patients with α-synucleinopathies.Brain research, , 02-01, Volume: 1680, 2018
Resveratrol alleviates motor and cognitive deficits and neuropathology in the A53T α-synuclein mouse model of Parkinson's disease.Food & function, , Dec-13, Volume: 9, Issue:12, 2018
Role of LRRK2 and SNCA in autosomal dominant Parkinson's disease in Turkey.Parkinsonism & related disorders, , Volume: 48, 2018
Reduced LRRK2 in association with retromer dysfunction in post-mortem brain tissue from LRRK2 mutation carriers.Brain : a journal of neurology, , 02-01, Volume: 141, Issue:2, 2018
Immunologic treatment of Parkinson's disease.Immunotherapy, , Volume: 10, Issue:2, 2018
123I-FP-CIT SPECT [(123) I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single photon emission computed tomography] Imaging in a p.A53T α-synuclein Parkinson's disease cohort versus Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:11, 2018
Potential neuroprotective effect of androst-5-ene-3β, 17β-diol (ADIOL) on the striatum, and substantia nigra in Parkinson's disease rat model.Journal of cellular physiology, , Volume: 233, Issue:8, 2018
Neuronal complex I deficiency occurs throughout the Parkinson's disease brain, but is not associated with neurodegeneration or mitochondrial DNA damage.Acta neuropathologica, , Volume: 135, Issue:3, 2018
Trichloroethylene and Parkinson's Disease: Risk Assessment.Molecular neurobiology, , Volume: 55, Issue:7, 2018
Pathological histone acetylation in Parkinson's disease: Neuroprotection and inhibition of microglial activation through SIRT 2 inhibition.Neuroscience letters, , 02-14, Volume: 666, 2018
Selective α-Synuclein Knockdown in Monoamine Neurons by Intranasal Oligonucleotide Delivery: Potential Therapy for Parkinson's Disease.Molecular therapy : the journal of the American Society of Gene Therapy, , 02-07, Volume: 26, Issue:2, 2018
Familial Parkinson's point mutation abolishes multiple system atrophy prion replication.Proceedings of the National Academy of Sciences of the United States of America, , 01-09, Volume: 115, Issue:2, 2018
C-terminal truncation exacerbates the aggregation and cytotoxicity of α-Synuclein: A vicious cycle in Parkinson's disease.Biochimica et biophysica acta. Molecular basis of disease, , Volume: 1864, Issue:12, 2018
Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide.Neuron, , 01-03, Volume: 97, Issue:1, 2018
Prion-like Propagation of α-Synuclein Is Regulated by the FcγRIIB-SHP-1/2 Signaling Pathway in Neurons.Cell reports, , 01-02, Volume: 22, Issue:1, 2018
α-Synuclein and Tau: Mitochondrial Kill Switches.Neuron, , 01-03, Volume: 97, Issue:1, 2018
Untangling alpha synuclein fibrils by graphene quantum dots.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:11, 2018
A refined concept: α-synuclein dysregulation disease.Neurochemistry international, , Volume: 119, 2018
Pathological role of lipid interaction with α-synuclein in Parkinson's disease.Neurochemistry international, , Volume: 119, 2018
Serum Mortalin Correlated with α-Synuclein as Serum Markers in Parkinson's Disease: A Pilot Study.Neuromolecular medicine, , Volume: 20, Issue:1, 2018
GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers.Proceedings of the National Academy of Sciences of the United States of America, , 01-23, Volume: 115, Issue:4, 2018
Nigral depigmentation reflects monoamine exhaustion as initial step to Parkinson's disease.Medical hypotheses, , Volume: 110, 2018
Identification of new α-synuclein regulator by nontraditional drug development pipeline.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:3, 2018
Genetics of Parkinson disease.Handbook of clinical neurology, , Volume: 147, 2018
Neuroprotective Effects of Filgrastim in Rotenone-Induced Parkinson's Disease in Rats: Insights into its Anti-Inflammatory, Neurotrophic, and Antiapoptotic Effects.Molecular neurobiology, , Volume: 55, Issue:8, 2018
NLRP3 Inflammasome-Related Proteins Are Upregulated in the Putamen of Patients With Multiple System Atrophy.Journal of neuropathology and experimental neurology, , 11-01, Volume: 77, Issue:11, 2018
Synapsin III is a key component of α-synuclein fibrils in Lewy bodies of PD brains.Brain pathology (Zurich, Switzerland), , Volume: 28, Issue:6, 2018
The relation between plasma α-synuclein level and clinical symptoms or signs of Parkinson's disease.Neurologia i neurochirurgia polska, , Volume: 52, Issue:2, 2018
Genomic DNA levels of mutant alpha-synuclein correlate with non-motor symptoms in an A53T Parkinson's disease mouse model.Neurochemistry international, , Volume: 114, 2018
A tango for two: Dopamine and α-synuclein synergy may explain nigrostriatal degeneration in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:2, 2018
Parkinson's disease from the gut.Brain research, , 08-15, Volume: 1693, Issue:Pt B, 2018
Functional Characterization of Novel Circular RNA Molecule, circzip-2 and Its Synthesizing Gene zip-2 in C. elegans Model of Parkinson's Disease.Molecular neurobiology, , Volume: 55, Issue:8, 2018
Unveiling a Selective Mechanism for the Inhibition of α-Synuclein Aggregation by β-Synuclein.International journal of molecular sciences, , Jan-24, Volume: 19, Issue:2, 2018
Insights into the Molecular Mechanisms of Alzheimer's and Parkinson's Diseases with Molecular Simulations: Understanding the Roles of Artificial and Pathological Missense Mutations in Intrinsically Disordered Proteins Related to Pathology.International journal of molecular sciences, , Jan-24, Volume: 19, Issue:2, 2018
Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo.Scientific reports, , 01-24, Volume: 8, Issue:1, 2018
The fold preference and thermodynamic stability of α-synuclein fibrils is encoded in the non-amyloid-β component region.Physical chemistry chemical physics : PCCP, , Feb-07, Volume: 20, Issue:6, 2018
Iron, Dopamine, and α-Synuclein Interactions in at-Risk Dopaminergic Neurons in Parkinson's Disease.Neuroscience bulletin, , Volume: 34, Issue:2, 2018
Long-lasting pathological consequences of overexpression-induced α-synuclein spreading in the rat brain.Aging cell, , Volume: 17, Issue:2, 2018
Isoindole Linkages Provide a Pathway for DOPAL-Mediated Cross-Linking of α-Synuclein.Biochemistry, , 03-06, Volume: 57, Issue:9, 2018
Spectrum of abnormalities of sympathetic tyrosine hydroxylase and alpha-synuclein in chronic autonomic failure.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 28, Issue:2, 2018
Insufficient evidence for pathogenicity of SNCA His50Gln (H50Q) in Parkinson's disease.Neurobiology of aging, , Volume: 64, 2018
Glucocerebrosidase and Parkinson Disease: Molecular, Clinical, and Therapeutic Implications.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, , Volume: 24, Issue:5, 2018
Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson's Disease in Rodents.Journal of Parkinson's disease, , Volume: 8, Issue:2, 2018
Neuroprotective effects of voluntary running on cognitive dysfunction in an α-synuclein rat model of Parkinson's disease.Neurobiology of aging, , Volume: 65, 2018
Evolution of cerebrospinal fluid total α-synuclein in Parkinson's disease.Parkinsonism & related disorders, , Volume: 49, 2018
Osmotic stress induced toxicity exacerbates Parkinson's associated effects via dysregulation of autophagy in transgenic C. elegans model.Cellular signalling, , Volume: 45, 2018
Drp-1 dependent mitochondrial fragmentation and protective autophagy in dopaminergic SH-SY5Y cells overexpressing alpha-synuclein.Molecular and cellular neurosciences, , Volume: 88, 2018
Acrolein-mediated neuronal cell death and alpha-synuclein aggregation: Implications for Parkinson's disease.Molecular and cellular neurosciences, , Volume: 88, 2018
A peptide-display protein scaffold to facilitate single molecule force studies of aggregation-prone peptides.Protein science : a publication of the Protein Society, , Volume: 27, Issue:7, 2018
New Developments in Genetic rat models of Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:5, 2018
A noble pathological role for alpha-synuclein in triggering neurodegeneration of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:3, 2018
Do subjects with minimal motor features have prodromal Parkinson disease?Annals of neurology, , Volume: 83, Issue:3, 2018
Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC.Acta neuropathologica communications, , 02-09, Volume: 6, Issue:1, 2018
Lack of pathogenic potential of peripheral α-synuclein aggregates from Parkinson's disease patients.Acta neuropathologica communications, , 02-08, Volume: 6, Issue:1, 2018
Naringenin Decreases α-Synuclein Expression and Neuroinflammation in MPTP-Induced Parkinson's Disease Model in Mice.Neurotoxicity research, , Volume: 33, Issue:3, 2018
The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity.Molecular neurobiology, , Volume: 55, Issue:9, 2018
Bimolecular Fluorescence Complementation of Alpha-synuclein Demonstrates its Oligomerization with Dopaminergic Phenotype in Mice.EBioMedicine, , Volume: 29, 2018
Relationship between cerebrospinal fluid biomarkers and structural brain network properties in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:3, 2018
Selective cognitive impairment and hyposmia in p.A53T Neurology, , 03-06, Volume: 90, Issue:10, 2018
From a Highly Disordered to a Metastable State: Uncovering Insights of α-Synuclein.ACS chemical neuroscience, , 05-16, Volume: 9, Issue:5, 2018
Alpha-synuclein inhibits Snx3-retromer-mediated retrograde recycling of iron transporters in S. cerevisiae and C. elegans models of Parkinson's disease.Human molecular genetics, , 05-01, Volume: 27, Issue:9, 2018
Shedding light on aberrant interactions - a review of modern tools for studying protein aggregates.The FEBS journal, , Volume: 285, Issue:19, 2018
Risk variants of the α-synuclein locus and REM sleep behavior disorder in Parkinson's disease: a genetic association study.BMC neurology, , Feb-21, Volume: 18, Issue:1, 2018
Lighting Up Alpha-synuclein Oligomers.EBioMedicine, , Volume: 29, 2018
α-synuclein (SNCA) but not dynamin 3 (DNM3) influences age at onset of leucine-rich repeat kinase 2 (LRRK2) Parkinson's disease in Spain.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:4, 2018
Long Road to Ruin: Noradrenergic Dysfunction in Neurodegenerative Disease.Trends in neurosciences, , Volume: 41, Issue:4, 2018
[Protective effect of curcumin on dopamine neurons in Parkinson's disease and its mechanism].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, , 05-25, Volume: 47, Issue:5, 2018
Locomotor differences in mice expressing wild-type human α-synuclein.Neurobiology of aging, , Volume: 65, 2018
α-Synuclein Oligomers Induce a Unique Toxic Tau Strain.Biological psychiatry, , 10-01, Volume: 84, Issue:7, 2018
[Symposium].Nihon saikingaku zasshi. Japanese journal of bacteriology, , Volume: 73, Issue:1, 2018
Alpha-Synuclein Glycation and the Action of Anti-Diabetic Agents in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 8, Issue:1, 2018
The concept of alpha-synuclein as a prion-like protein: ten years after.Cell and tissue research, , Volume: 373, Issue:1, 2018
Analysis of age-related changes in psychosine metabolism in the human brain.PloS one, , Volume: 13, Issue:2, 2018
Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 03-13, Volume: 115, Issue:11, 2018
Does Parkinson's disease start in the gut?Arquivos de neuro-psiquiatria, , Volume: 76, Issue:2, 2018
Activating Autophagy as a Therapeutic Strategy for Parkinson's Disease.CNS drugs, , Volume: 32, Issue:1, 2018
Measurements of auto-antibodies to α-synuclein in the serum and cerebral spinal fluids of patients with Parkinson's disease.Journal of neurochemistry, , Volume: 145, Issue:6, 2018
Correlations between CSF proteins and spontaneous neuronal activity in Parkinson's disease.Neuroscience letters, , 04-23, Volume: 673, 2018
Lysosomal response in relation to α-synuclein pathology differs between Parkinson's disease and multiple system atrophy.Neurobiology of disease, , Volume: 114, 2018
Effects of Ginkgo Biloba Extract on A53T α-Synuclein Transgenic Mouse Models of Parkinson's Disease.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, , Volume: 45, Issue:2, 2018
Genetics of Synucleinopathies.Cold Spring Harbor perspectives in medicine, , 06-01, Volume: 8, Issue:6, 2018
Autonomic dysfunction in genetic forms of synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:3, 2018
Cytotoxic Oligomers and Fibrils Trapped in a Gel-like State of α-Synuclein Assemblies.Angewandte Chemie (International ed. in English), , 05-04, Volume: 57, Issue:19, 2018
Detection of amyloid fibrils in Parkinson's disease using plasmonic chirality.Proceedings of the National Academy of Sciences of the United States of America, , 03-27, Volume: 115, Issue:13, 2018
Interaction of amyloidogenic proteins in pancreatic β cells from subjects with synucleinopathies.Acta neuropathologica, , Volume: 135, Issue:6, 2018
Extracellular α-Synuclein Disrupts Membrane Nanostructure and Promotes S-Nitrosylation-Induced Neuronal Cell Death.Biomacromolecules, , 04-09, Volume: 19, Issue:4, 2018
Early fine motor impairment and behavioral dysfunction in (Thy-1)-h[A30P] alpha-synuclein mice.Brain and behavior, , Volume: 8, Issue:3, 2018
Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy.Molecular neurodegeneration, , 03-15, Volume: 13, Issue:1, 2018
Modulation of β-glucocerebrosidase increases α-synuclein secretion and exosome release in mouse models of Parkinson's disease.Human molecular genetics, , 05-15, Volume: 27, Issue:10, 2018
Cerebrospinal fluid levels of alpha-synuclein in PARKINSON'S disease: Another long and winding road.Parkinsonism & related disorders, , Volume: 49, 2018
The dopamine transporter: An unrecognized nexus for dysfunctional peripheral immunity and signaling in Parkinson's Disease.Brain, behavior, and immunity, , Volume: 70, 2018
N-palmitoylethanolamide Prevents Parkinsonian Phenotypes in Aged Mice.Molecular neurobiology, , Volume: 55, Issue:11, 2018
Phospholipase D1 downregulation by α-synuclein: Implications for neurodegeneration in Parkinson's disease.Biochimica et biophysica acta. Molecular and cell biology of lipids, , Volume: 1863, Issue:6, 2018
Structural and Aggregation Properties of Alpha-Synuclein Linked to Phospholipase A2 Action.Protein and peptide letters, , Volume: 25, Issue:4, 2018
Acid ceramidase inhibition ameliorates α-synuclein accumulation upon loss of GBA1 function.Human molecular genetics, , 06-01, Volume: 27, Issue:11, 2018
Diabetes Mellitus as a Risk Factor for Parkinson's Disease: a Molecular Point of View.Molecular neurobiology, , Volume: 55, Issue:11, 2018
Alpha-synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation.EMBO reports, , Volume: 19, Issue:5, 2018
Alpha-synuclein is present in dental calculus but not altered in Parkinson's disease patients in comparison to controls.Journal of neurology, , Volume: 265, Issue:6, 2018
Pulsed Hydrogen-Deuterium Exchange Illuminates the Aggregation Kinetics of α-Synuclein, the Causative Agent for Parkinson's Disease.ACS chemical neuroscience, , 06-20, Volume: 9, Issue:6, 2018
Paradoxical Effect of Trehalose on the Aggregation of α-Synuclein: Expedites Onset of Aggregation yet Reduces Fibril Load.ACS chemical neuroscience, , 06-20, Volume: 9, Issue:6, 2018
Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding.Protein science : a publication of the Protein Society, , Volume: 27, Issue:7, 2018
Sequestration of synaptic proteins by alpha-synuclein aggregates leading to neurotoxicity is inhibited by small peptide.PloS one, , Volume: 13, Issue:4, 2018
Iron Redox Chemistry Promotes Antiparallel Oligomerization of α-Synuclein.Journal of the American Chemical Society, , 04-18, Volume: 140, Issue:15, 2018
Targeting AMPK Signaling as a Neuroprotective Strategy in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 8, Issue:2, 2018
27-Hydroxycholesterol increases α-synuclein protein levels through proteasomal inhibition in human dopaminergic neurons.BMC neuroscience, , 04-03, Volume: 19, Issue:1, 2018
Cx3cr1-deficiency exacerbates alpha-synuclein-A53T induced neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease.Glia, , Volume: 66, Issue:8, 2018
Diabetes mellitus and Parkinson disease.Neurology, , 05-08, Volume: 90, Issue:19, 2018
Unravelling the inhibitory activity of Chlamydomonas reinhardtii sulfated polysaccharides against α-Synuclein fibrillation.Scientific reports, , 04-09, Volume: 8, Issue:1, 2018
Degradation of alpha-synuclein by dendritic cell factor 1 delays neurodegeneration and extends lifespan in Drosophila.Neurobiology of aging, , Volume: 67, 2018
2-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease.Molecular neurobiology, , Volume: 55, Issue:12, 2018
Structure and dynamics of the extended-helix state of alpha-synuclein: Intrinsic lability of the linker region.Protein science : a publication of the Protein Society, , Volume: 27, Issue:7, 2018
Inducible Alpha-Synuclein Expression Affects Human Neural Stem Cells' Behavior.Stem cells and development, , 07-15, Volume: 27, Issue:14, 2018
Detection of alpha-synuclein conformational variants from gastro-intestinal biopsy tissue as a potential biomarker for Parkinson's disease.Neuropathology and applied neurobiology, , Volume: 44, Issue:7, 2018
Nitration of microtubules blocks axonal mitochondrial transport in a human pluripotent stem cell model of Parkinson's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 32, Issue:10, 2018
Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age.Scientific reports, , 10-12, Volume: 8, Issue:1, 2018
ELISA method to detect α-synuclein oligomers in cell and animal models.PloS one, , Volume: 13, Issue:4, 2018
Alpha-synuclein mitochondrial interaction leads to irreversible translocation and complex I impairment.Archives of biochemistry and biophysics, , 08-01, Volume: 651, 2018
ɑ-Synuclein strains and seeding in Parkinson's disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences.Cell and tissue research, , Volume: 373, Issue:1, 2018
Targeted Therapies for Parkinson's Disease: From Genetics to the Clinic.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:5, 2018
Synergistic Amyloid Switch Triggered by Early Heterotypic Oligomerization of Intrinsically Disordered α-Synuclein and Tau.Journal of molecular biology, , 08-03, Volume: 430, Issue:16, 2018
Plasma α-synuclein and cognitive impairment in the Parkinson's Associated Risk Syndrome: A pilot study.Neurobiology of disease, , Volume: 116, 2018
An Enriched Environment Ameliorates Oxidative Stress and Olfactory Dysfunction in Parkinson's Disease with α-Synucleinopathy.Cell transplantation, , Volume: 27, Issue:5, 2018
Structural characteristics and membrane interactions of tandem α-synuclein oligomers.Scientific reports, , 04-30, Volume: 8, Issue:1, 2018
Emerging disease-modifying strategies targeting α-synuclein for the treatment of Parkinson's disease.British journal of pharmacology, , Volume: 175, Issue:15, 2018
(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis.Scientific reports, , 05-03, Volume: 8, Issue:1, 2018
The potential of zwitterionic nanoliposomes against neurotoxic alpha-synuclein aggregates in Parkinson's Disease.Nanoscale, , May-17, Volume: 10, Issue:19, 2018
The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration.FEBS letters, , Volume: 592, Issue:23, 2018
The cortical excitability profile of patients with the G209A SNCA mutation versus patients with sporadic Parkinson's disease: A transcranial magnetic stimulation study.Neurophysiologie clinique = Clinical neurophysiology, , Volume: 48, Issue:4, 2018
Toward deciphering the mechanistic role of variations in the Rep1 repeat site in the transcription regulation of SNCA gene.Neurogenetics, , Volume: 19, Issue:3, 2018
Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 06-19, Volume: 115, Issue:25, 2018
Phosphorylated α-synuclein in the retina is a biomarker of Parkinson's disease pathology severity.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:8, 2018
A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia.Acta neuropathologica communications, , 05-10, Volume: 6, Issue:1, 2018
Gangliosides, α-Synuclein, and Parkinson's Disease.Progress in molecular biology and translational science, , Volume: 156, 2018
α‑synuclein induces apoptosis of astrocytes by causing dysfunction of the endoplasmic reticulum‑Golgi compartment.Molecular medicine reports, , Volume: 18, Issue:1, 2018
Alpha Synuclein Fibrils Contain Multiple Binding Sites for Small Molecules.ACS chemical neuroscience, , 11-21, Volume: 9, Issue:11, 2018
Different Structural Conformers of Monomeric α-Synuclein Identified after Lyophilizing and Freezing.Analytical chemistry, , 06-05, Volume: 90, Issue:11, 2018
Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve.Molecular neurodegeneration, , 05-11, Volume: 13, Issue:1, 2018
Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in α-Synuclein Aggregation Disorders.EBioMedicine, , Volume: 31, 2018
[Multi-Organ Distribution of Alpha-Synuclein Pathology in Dementia with Lewy Bodies].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 70, Issue:5, 2018
[Targeting Transcellular Transport of α-Synuclein for Developing Disease-Modifying Therapies for Synucleinopathy].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 70, Issue:5, 2018
Identifying genes in Parkinson disease: state of the art.The Medical journal of Australia, , 05-21, Volume: 208, Issue:9, 2018
α-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's disease.The EMBO journal, , 06-15, Volume: 37, Issue:12, 2018
α-Synuclein aggregates in labial salivary glands of idiopathic rapid eye movement sleep behavior disorder.Sleep, , 08-01, Volume: 41, Issue:8, 2018
Candidate biomarkers for Parkinson's disease.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 104, 2018
Beneficial Effects of Green Tea Catechins on Neurodegenerative Diseases.Molecules (Basel, Switzerland), , May-29, Volume: 23, Issue:6, 2018
Dopamine Transporter/α-Synuclein Complexes Are Altered in the Post Mortem Caudate Putamen of Parkinson's Disease: An In Situ Proximity Ligation Assay Study.International journal of molecular sciences, , May-30, Volume: 19, Issue:6, 2018
Linking Neuroinflammation and Neurodegeneration in Parkinson's Disease.Journal of immunology research, , Volume: 2018, 2018
Comparative Analysis of the Conformation, Aggregation, Interaction, and Fibril Morphologies of Human α-, β-, and γ-Synuclein Proteins.Biochemistry, , 07-03, Volume: 57, Issue:26, 2018
LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons.Acta neuropathologica communications, , 05-31, Volume: 6, Issue:1, 2018
SNCA variants and alpha-synuclein level in CD45+ blood cells in Parkinson's disease.Journal of the neurological sciences, , 12-15, Volume: 395, 2018
SNCA REP1 and Parkinson's disease.Neuroscience letters, , 08-24, Volume: 682, 2018
Is Parkinson's disease a lysosomal disorder?Brain : a journal of neurology, , 08-01, Volume: 141, Issue:8, 2018
Impaired Photic Entrainment of Spontaneous Locomotor Activity in Mice Overexpressing Human Mutant α-Synuclein.International journal of molecular sciences, , Jun-03, Volume: 19, Issue:6, 2018
FLIM analysis of intracellular markers associated with the development of Parkinson's disease in cellular model.Physiological research, , 12-31, Volume: 67, Issue:Suppl 4, 2018
Co-aggregation of pro-inflammatory S100A9 with α-synuclein in Parkinson's disease: ex vivo and in vitro studies.Journal of neuroinflammation, , Jun-04, Volume: 15, Issue:1, 2018
Regional expression of genes mediating trans-synaptic alpha-synuclein transfer predicts regional atrophy in Parkinson disease.NeuroImage. Clinical, , Volume: 18, 2018
The Challenge of the Pathogenesis of Parkinson's Disease: Is Autoimmunity the Culprit?Frontiers in immunology, , Volume: 9, 2018
What autoantibodies tell us about the pathogenesis of Parkinson's disease: An Editorial for 'Measurements of auto-antibodies to α-synuclein in the serum and cerebral spinal fluids of patients with Parkinson's disease' on page 489.Journal of neurochemistry, , Volume: 145, Issue:6, 2018
Special issue "Parkinson's disease".Cell and tissue research, , Volume: 373, Issue:1, 2018
Rapid eye movement sleep behavior disorder and the link to alpha-synucleinopathies.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, , Volume: 129, Issue:8, 2018
Parkinson's disease and Alzheimer's disease: a Mendelian randomization study.BMC medical genetics, , 12-31, Volume: 19, Issue:Suppl 1, 2018
Preparation of α-Synuclein Amyloid Assemblies for Toxicity Experiments.Methods in molecular biology (Clifton, N.J.), , Volume: 1779, 2018
Generation and Characterization of Stable α-Synuclein Oligomers.Methods in molecular biology (Clifton, N.J.), , Volume: 1779, 2018
Effects of Novel Calpain Inhibitors in Transgenic Animal Model of Parkinson's disease/dementia with Lewy bodies.Scientific reports, , 12-27, Volume: 8, Issue:1, 2018
In Vitro Analysis of α-Synuclein Amyloid Formation and Cross-Reactivity.Methods in molecular biology (Clifton, N.J.), , Volume: 1779, 2018
Prion-like propagation of pathology in Parkinson disease.Handbook of clinical neurology, , Volume: 153, 2018
A novel link between trafficking and Lewy body disorders.The Lancet. Neurology, , Volume: 17, Issue:7, 2018
Effect of capsaicin on the oxidative stress and dopamine content in the transgenic Drosophila model of Parkinson's disease.Acta biologica Hungarica, , Volume: 69, Issue:2, 2018
Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease.Nature medicine, , Volume: 24, Issue:7, 2018
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.Nature communications, , 06-12, Volume: 9, Issue:1, 2018
The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson's disease mouse model.Human molecular genetics, , 07-01, Volume: 27, Issue:13, 2018
Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson's disease.Cell death & disease, , 06-13, Volume: 9, Issue:6, 2018
MDSGene: Closing Data Gaps in Genotype-Phenotype Correlations of Monogenic Parkinson's Disease.Journal of Parkinson's disease, , Volume: 8, Issue:s1, 2018
A single cell high content assay detects mitochondrial dysfunction in iPSC-derived neurons with mutations in SNCA.Scientific reports, , 06-13, Volume: 8, Issue:1, 2018
Cell Biology and Pathophysiology of α-Synuclein.Cold Spring Harbor perspectives in medicine, , 03-01, Volume: 8, Issue:3, 2018
Parkinson's Disease Associated α-Synuclein Familial Mutants Promote Dopaminergic Neuronal Death in Drosophila melanogaster.ACS chemical neuroscience, , 11-21, Volume: 9, Issue:11, 2018
Generation of gene-corrected iPSC line from Parkinson's disease patient iPSC line with alpha-SNCA A53T mutation.Stem cell research, , Volume: 30, 2018
Nano-particle mediated inhibition of Parkinson's disease using computational biology approach.Scientific reports, , 06-15, Volume: 8, Issue:1, 2018
Updating Our Definitions of Parkinson's Disease for a Molecular Age.Journal of Parkinson's disease, , Volume: 8, Issue:s1, 2018
Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to α-Synuclein Gain.Cell metabolism, , 10-02, Volume: 28, Issue:4, 2018
The Gut and Parkinson's Disease: Hype or Hope?Journal of Parkinson's disease, , Volume: 8, Issue:s1, 2018
Challenges in Passive Immunization Strategies to Treat Parkinson Disease.JAMA neurology, , 10-01, Volume: 75, Issue:10, 2018
Safety and Tolerability of Multiple Ascending Doses of PRX002/RG7935, an Anti-α-Synuclein Monoclonal Antibody, in Patients With Parkinson Disease: A Randomized Clinical Trial.JAMA neurology, , 10-01, Volume: 75, Issue:10, 2018
Parkinson Diseases in the 2020s and Beyond: Replacing Clinico-Pathologic Convergence With Systems Biology Divergence.Journal of Parkinson's disease, , Volume: 8, Issue:s1, 2018
Somatic copy number gains of α-synuclein (SNCA) in Parkinson's disease and multiple system atrophy brains.Brain : a journal of neurology, , 08-01, Volume: 141, Issue:8, 2018
Alpha-synuclein delays mitophagy and targeting Miro rescues neuron loss in Parkinson's models.Acta neuropathologica, , Volume: 136, Issue:4, 2018
Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases.The FEBS journal, , Volume: 285, Issue:19, 2018
[GBA mutations and Parkinson's disease].Sheng li xue bao : [Acta physiologica Sinica], , Jun-25, Volume: 70, Issue:3, 2018
Evidence for dopaminergic axonal degeneration as an early pathological process in Parkinson's disease.Parkinsonism & related disorders, , Volume: 56, 2018
The enteric nervous system in PD: gateway, bystander victim, or source of solutions.Cell and tissue research, , Volume: 373, Issue:1, 2018
Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils.Proceedings of the National Academy of Sciences of the United States of America, , 07-10, Volume: 115, Issue:28, 2018
α-Synuclein and Polyunsaturated Fatty Acids: Molecular Basis of the Interaction and Implication in Neurodegeneration.Molecules (Basel, Switzerland), , Jun-25, Volume: 23, Issue:7, 2018
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.ACS chemical biology, , 08-17, Volume: 13, Issue:8, 2018
CircSNCA downregulation by pramipexole treatment mediates cell apoptosis and autophagy in Parkinson's disease by targeting miR-7.Aging, , Jun-28, Volume: 10, Issue:6, 2018
Lipid vesicles affect the aggregation of 4-hydroxy-2-nonenal-modified α-synuclein oligomers.Biochimica et biophysica acta. Molecular basis of disease, , Volume: 1864, Issue:9 Pt B, 2018
Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity.Acta neuropathologica communications, , 07-02, Volume: 6, Issue:1, 2018
Cryo-EM structure of alpha-synuclein fibrils.eLife, , 07-03, Volume: 7, 2018
Real-time determination of aggregated alpha-synuclein induced membrane disruption at neuroblastoma cells using scanning ion conductance microscopy.Faraday discussions, , 10-01, Volume: 210, Issue:0, 2018
Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease.Acta neuropathologica communications, , 07-05, Volume: 6, Issue:1, 2018
Localized Induction of Wild-Type and Mutant Alpha-Synuclein Aggregation Reveals Propagation along Neuroanatomical Tracts.Journal of virology, , 09-15, Volume: 92, Issue:18, 2018
miR-486-3p Influences the Neurotoxicity of a-Synuclein by Targeting the SIRT2 Gene and the Polymorphisms at Target Sites Contributing to Parkinson's Disease.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , Volume: 51, Issue:6, 2018
Graphene quantum dots prevent α-synucleinopathy in Parkinson's disease.Nature nanotechnology, , Volume: 13, Issue:9, 2018
The lysosomal membrane protein LAMP2A promotes autophagic flux and prevents SNCA-induced Parkinson disease-like symptoms in the Drosophila brain.Autophagy, , Volume: 14, Issue:11, 2018
In Silico, in Vitro, and in Vivo Evaluation of New Candidates for α-Synuclein PET Imaging.Molecular pharmaceutics, , 08-06, Volume: 15, Issue:8, 2018
"Cell-addictive" dual-target traceable nanodrug for Parkinson's disease treatment via flotillins pathway.Theranostics, , Volume: 8, Issue:19, 2018
Gastrointestinal nervous system α-synuclein as a potential biomarker of Parkinson disease.Medicine, , Volume: 97, Issue:28, 2018
Identification of an Alternatively Spliced α-Synuclein Isoform That Generates a 41-Amino Acid N-Terminal Truncated Peptide, 41-syn: Role in Dopamine Homeostasis.ACS chemical neuroscience, , 12-19, Volume: 9, Issue:12, 2018
In vivo quantification of glial activation in minipigs overexpressing human α-synuclein.Synapse (New York, N.Y.), , Volume: 72, Issue:12, 2018
Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation.Journal of visualized experiments : JoVE, , 06-26, Issue:136, 2018
Parkinson's Disease: Alpha Synuclein, Heme Oxygenase and Biotherapeutic Countermeasures.Current pharmaceutical design, , Volume: 24, Issue:20, 2018
Effect of cabergoline alginate nanocomposite on the transgenic Drosophila melanogaster model of Parkinson's disease.Toxicology mechanisms and methods, , Volume: 28, Issue:9, 2018
Mitochondrial dysfunction in protein conformational disorders.Journal of genetics, , Volume: 97, Issue:3, 2018
Regulation of membrane dynamics by Parkinson's disease-associated genes.Journal of genetics, , Volume: 97, Issue:3, 2018
Determinants of dopaminergic neuron loss in Parkinson's disease.The FEBS journal, , Volume: 285, Issue:19, 2018
The effect of truncation on prion-like properties of α-synuclein.The Journal of biological chemistry, , 09-07, Volume: 293, Issue:36, 2018
Exercise as therapy for Parkinson's?Aging, , Jul-20, Volume: 10, Issue:7, 2018
LRRK2 activation in idiopathic Parkinson's disease.Science translational medicine, , 07-25, Volume: 10, Issue:451, 2018
The Protective Role of Brain CYP2J in Parkinson's Disease Models.Oxidative medicine and cellular longevity, , Volume: 2018, 2018
Synapsin III deficiency hampers α-synuclein aggregation, striatal synaptic damage and nigral cell loss in an AAV-based mouse model of Parkinson's disease.Acta neuropathologica, , Volume: 136, Issue:4, 2018
Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson's disease.Cell death & disease, , 07-26, Volume: 9, Issue:8, 2018
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells.Chembiochem : a European journal of chemical biology, , 10-04, Volume: 19, Issue:19, 2018
Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson's disease brains with Lewy body pathology.Brain research, , 12-15, Volume: 1701, 2018
Dysregulation of bcl-2 enhanced rotenone-induced α-synuclein aggregation associated with autophagic pathways.Neuroreport, , 09-26, Volume: 29, Issue:14, 2018
[Autonomic Dysfunction and Skin Biopsy in Dementia with Lewy Bodies].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 70, Issue:8, 2018
Neuropsychiatric symptoms and α-Synuclein profile of patients with Parkinson's disease dementia, dementia with Lewy bodies and Alzheimer's disease.Journal of neurology, , Volume: 265, Issue:10, 2018
Ratios of proteins in cerebrospinal fluid in Parkinson's disease cognitive decline: prospective study.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:11, 2018
REM behavior disorder predicts motor progression and cognitive decline in Parkinson disease.Neurology, , 09-04, Volume: 91, Issue:10, 2018
The "when" and "where" of α-synucleinopathies: Insights from REM sleep behavior disorder.Neurology, , 09-04, Volume: 91, Issue:10, 2018
14-3-3 Proteins Reduce Cell-to-Cell Transfer and Propagation of Pathogenic α-Synuclein.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 09-19, Volume: 38, Issue:38, 2018
Yeast red pigment modifies cloned human α-synuclein pathogenesis in Parkinson disease models in Saccharomyces cerevisiae and Drosophila melanogaster.Neurochemistry international, , Volume: 120, 2018
An updated analysis with 45,078 subjects confirms the association between SNCA rs11931074 and Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 39, Issue:12, 2018
LRRK2 G2019S Mutation Inhibits Degradation of α-Synuclein in an In Vitro Model of Parkinson's Disease.Current medical science, , Volume: 38, Issue:6, 2018
CRISPR/Cas9-Mediated Generation of Guangxi Bama Minipigs Harboring Three Mutations in α-Synuclein Causing Parkinson's Disease.Scientific reports, , 08-20, Volume: 8, Issue:1, 2018
Reply To: Detection of Alpha-Synuclein in Saliva: The Importance of Preanalytical Assessment.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:6, 2018
Detection of α-Synuclein in Saliva: The Importance of Preanalytical Assessment.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:6, 2018
Skin Nerve Phosphorylated α-Synuclein Deposits in Parkinson Disease With Orthostatic Hypotension.Journal of neuropathology and experimental neurology, , 10-01, Volume: 77, Issue:10, 2018
Amyloid oligomerization of the Parkinson's disease related protein α-synuclein impacts on its curvature-membrane sensitivity.Journal of neurochemistry, , Volume: 147, Issue:4, 2018
Diagnostic biomarkers for Parkinson's disease at a glance: where are we?Journal of neural transmission (Vienna, Austria : 1996), , Volume: 125, Issue:10, 2018
Intranasal carnosine attenuates transcriptomic alterations and improves mitochondrial function in the Thy1-aSyn mouse model of Parkinson's disease.Molecular genetics and metabolism, , Volume: 125, Issue:3, 2018
A comprehensive analysis of SNCA-related genetic risk in sporadic parkinson disease.Annals of neurology, , Volume: 84, Issue:1, 2018
Modeling Parkinson's Disease Using Patient-specific Induced Pluripotent Stem Cells.Journal of Parkinson's disease, , Volume: 8, Issue:4, 2018
Separation and determination of alpha-synuclein monomeric and oligomeric species using two electrophoretic approaches.Electrophoresis, , Volume: 39, Issue:23, 2018
Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson's disease and DLB.Proceedings of the National Academy of Sciences of the United States of America, , 12-18, Volume: 115, Issue:51, 2018
Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson's disease.Journal of neuroinflammation, , Aug-30, Volume: 15, Issue:1, 2018
REM sleep behaviour disorder.Nature reviews. Disease primers, , 08-30, Volume: 4, Issue:1, 2018
Intestinal Pathology and Gut Microbiota Alterations in a Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Mouse Model of Parkinson's Disease.Neurochemical research, , Volume: 43, Issue:10, 2018
Is constipation in Parkinson's disease caused by gut or brain pathology?Parkinsonism & related disorders, , Volume: 55, 2018
Local and Global Dynamics in Intrinsically Disordered Synuclein.Angewandte Chemie (International ed. in English), , 11-12, Volume: 57, Issue:46, 2018
Cerebrospinal fluid concentrations of inflammatory markers in Parkinson's disease and atypical parkinsonian disorders.Scientific reports, , 09-05, Volume: 8, Issue:1, 2018
What is the Evidence That Parkinson's Disease is a Prion Disorder, Which Originates in the Gut?International journal of molecular sciences, , Nov-12, Volume: 19, Issue:11, 2018
α-synuclein expression from a single copy transgene increases sensitivity to stress and accelerates neuronal loss in genetic models of Parkinson's disease.Experimental neurology, , Volume: 310, 2018
Distinct functional roles of Vps41-mediated neuroprotection in Alzheimer's and Parkinson's disease models of neurodegeneration.Human molecular genetics, , 12-15, Volume: 27, Issue:24, 2018
Alpha-synuclein aggregates in the parotid gland of idiopathic REM sleep behavior disorder.Sleep medicine, , Volume: 52, 2018
Alpha-synuclein and the prion hypothesis in Parkinson's disease.Revue neurologique, , Volume: 174, Issue:9, 2018
α-Synuclein strains in multiple system atrophy: A product of their environment?Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:8, 2018
α-Synuclein antibody 5G4 identifies manifest and prodromal Parkinson's disease in colonic mucosa.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:8, 2018
Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experiment.Acta neuropathologica communications, , 09-19, Volume: 6, Issue:1, 2018
A Cortical Pathogenic Theory of Parkinson's Disease.Neuron, , 09-19, Volume: 99, Issue:6, 2018
Feasibility and Safety of Multicenter Tissue and Biofluid Sampling for α-Synuclein in Parkinson's Disease: The Systemic Synuclein Sampling Study (S4).Journal of Parkinson's disease, , Volume: 8, Issue:4, 2018
Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons.Proceedings of the National Academy of Sciences of the United States of America, , 10-09, Volume: 115, Issue:41, 2018
Parkinson-Associated SNCA Enhancer Variants Revealed by Open Chromatin in Mouse Dopamine Neurons.American journal of human genetics, , 12-06, Volume: 103, Issue:6, 2018
Skin α-synuclein deposits differ in clinical variants of synucleinopathy: an in vivo study.Scientific reports, , 09-24, Volume: 8, Issue:1, 2018
Time-Resolved NMR Analysis of Proteolytic α-Synuclein Processing in vitro and in cellulo.Proteomics, , Volume: 18, Issue:21-22, 2018
Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD.Molecular therapy : the journal of the American Society of Gene Therapy, , 11-07, Volume: 26, Issue:11, 2018
Mitochondrial activity in the frontal cortex area 8 and angular gyrus in Parkinson's disease and Parkinson's disease with dementia.Brain pathology (Zurich, Switzerland), , Volume: 28, Issue:1, 2018
Cortical Thinning Associated with Age and CSF Biomarkers in Early Parkinson's Disease Is Modified by the SNCA rs356181 Polymorphism.Neuro-degenerative diseases, , Volume: 18, Issue:5-6, 2018
Effects of different force fields on the structural character of α synuclein β-hairpin peptide (35-56) in aqueous environment.Journal of biomolecular structure & dynamics, , Volume: 36, Issue:2, 2018
Lewy Body Dementia.Clinics in geriatric medicine, , Volume: 34, Issue:4, 2018
α-Synuclein species as potential cerebrospinal fluid biomarkers for dementia with lewy bodies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:11, 2018
The use of nonhuman primate models to understand processes in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 125, Issue:3, 2018
Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson's disease.Neurobiology of disease, , Volume: 109, Issue:Pt B, 2018
Genotype-phenotype relations for the Parkinson's disease genes SNCA, LRRK2, VPS35: MDSGene systematic review.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:12, 2018
α-Synuclein nonhuman primate models of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 125, Issue:3, 2018
Gene therapy approaches in the non-human primate model of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 125, Issue:3, 2018
Modulatory Role of Nurr1 Activation and Thrombin Inhibition in the Neuroprotective Effects of Dabigatran Etexilate in Rotenone-Induced Parkinson's Disease in Rats.Molecular neurobiology, , Volume: 55, Issue:5, 2018
Alpha-Synuclein Toxicity on Protein Quality Control, Mitochondria and Endoplasmic Reticulum.Neurochemical research, , Volume: 43, Issue:12, 2018
The 200-year journey of Parkinson disease: Reflecting on the past and looking towards the future.Parkinsonism & related disorders, , Volume: 46 Suppl 1, 2018
Role of Sporadic Parkinson Disease Associated Mutations A18T and A29S in Enhanced α-Synuclein Fibrillation and Cytotoxicity.ACS chemical neuroscience, , 02-21, Volume: 9, Issue:2, 2018
How does parkinson's disease begin? Perspectives on neuroanatomical pathways, prions, and histology.Movement disorders : official journal of the Movement Disorder Society, , Volume: 33, Issue:1, 2018
Possible Role of the Polyglutamine Elongation in Evolution of Amyloid-Related Evolvability.Journal of Huntington's disease, , Volume: 7, Issue:4, 2018
Gut-brain and brain-gut axis in Parkinson's disease models: Effects of a uridine and fish oil diet.Nutritional neuroscience, , Volume: 21, Issue:6, 2018
Holothuria scabra extracts exhibit anti-Parkinson potential in C. elegans: A model for anti-Parkinson testing.Nutritional neuroscience, , Volume: 21, Issue:6, 2018
Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale.Nano letters, , 12-12, Volume: 18, Issue:12, 2018
Manganese exposure: Linking down-regulation of miRNA-7 and miRNA-433 with α-synuclein overexpression and risk of idiopathic Parkinson's disease.Toxicology in vitro : an international journal published in association with BIBRA, , Volume: 46, 2018
Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice.Science translational medicine, , 10-31, Volume: 10, Issue:465, 2018
Curcumin affords neuroprotection and inhibits α-synuclein aggregation in lipopolysaccharide-induced Parkinson's disease model.Inflammopharmacology, , Volume: 26, Issue:2, 2018
Intercellular transfer of pathogenic α-synuclein by extracellular vesicles is induced by the lipid peroxidation product 4-hydroxynonenal.Neurobiology of aging, , Volume: 61, 2018
Effect of optogenetic modulation on entopeduncular input affects thalamic discharge and behavior in an AAV2-α-synuclein-induced hemiparkinson rat model.Neuroscience letters, , Jan-01, Volume: 662, 2018
Levels of α- and β-synuclein regulate cellular susceptibility to toxicity from α-synuclein oligomers.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 32, Issue:2, 2018
The vermiform appendix impacts the risk of developing Parkinson's disease.Science translational medicine, , 10-31, Volume: 10, Issue:465, 2018
Dexamethasone Inhibits Copper-Induced Alpha-Synuclein Aggregation by a Metallothionein-Dependent Mechanism.Neurotoxicity research, , Volume: 33, Issue:2, 2018
Molecular mechanisms of α-synuclein and GBA1 in Parkinson's disease.Cell and tissue research, , Volume: 373, Issue:1, 2018
Updates on immunity and inflammation in Parkinson disease pathology.Journal of neuroscience research, , Volume: 96, Issue:3, 2018
New Frontiers in Parkinson's Disease: From Genetics to the Clinic.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 10-31, Volume: 38, Issue:44, 2018
Order and disorder in the physiological membrane binding of α-synuclein.Current opinion in structural biology, , Volume: 48, 2018
Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease.Science (New York, N.Y.), , 11-02, Volume: 362, Issue:6414, 2018
Alpha-synuclein dimerization in erythrocytes of patients with genetic and non-genetic forms of Parkinson's Disease.Neuroscience letters, , 04-13, Volume: 672, 2018
Microarray analysis of an synthetic α-synuclein induced cellular model reveals the expression profile of long non-coding RNA in Parkinson's disease.Brain research, , Jan-01, Volume: 1678, 2018
Genetics of Parkinson's disease and related disorders.Journal of medical genetics, , Volume: 55, Issue:2, 2018
Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease.Behavioural brain research, , Feb-26, Volume: 339, 2018
The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson's disease.Scientific reports, , 11-01, Volume: 8, Issue:1, 2018
Metals and Parkinson's Disease: Mechanisms and Biochemical Processes.Current medicinal chemistry, , Volume: 25, Issue:19, 2018
Alpha-synuclein, Proteotoxicity and Parkinson's Disease: Search for Neuroprotective Therapy.Current neuropharmacology, , Volume: 16, Issue:7, 2018
Structural features of α-synuclein amyloid fibrils revealed by Raman spectroscopy.The Journal of biological chemistry, , 01-19, Volume: 293, Issue:3, 2018
Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes.Journal of neuroinflammation, , Dec-11, Volume: 14, Issue:1, 2017
mTOR Signaling in Parkinson's Disease.Neuromolecular medicine, , Volume: 19, Issue:1, 2017
FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome.Proceedings of the National Academy of Sciences of the United States of America, , 12-26, Volume: 114, Issue:52, 2017
Unraveling amyloid formation paths of Parkinson's disease protein α-synuclein triggered by anionic vesicles.Quarterly reviews of biophysics, , Volume: 50, 2017
microRNAs in Parkinson's Disease: From Pathogenesis to Novel Diagnostic and Therapeutic Approaches.International journal of molecular sciences, , Dec-13, Volume: 18, Issue:12, 2017
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers.Science (New York, N.Y.), , 12-15, Volume: 358, Issue:6369, 2017
Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation.Brain research bulletin, , Volume: 133, 2017
α-Synuclein structural features inhibit harmful polyunsaturated fatty acid oxidation, suggesting roles in neuroprotection.The Journal of biological chemistry, , 04-28, Volume: 292, Issue:17, 2017
From Yeast to Patients: The Audacity and Vision of Susan Lindquist.Cell systems, , 02-22, Volume: 4, Issue:2, 2017
EGCG-mediated Protection of the Membrane Disruption and Cytotoxicity Caused by the 'Active Oligomer' of α-Synuclein.Scientific reports, , 12-20, Volume: 7, Issue:1, 2017
α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson's disease patients.Scientific reports, , 02-23, Volume: 7, 2017
Running wheel exercise reduces α-synuclein aggregation and improves motor and cognitive function in a transgenic mouse model of Parkinson's disease.PloS one, , Volume: 12, Issue:12, 2017
Traffic jams and the complex role of α-Synuclein aggregation in Parkinson disease.Small GTPases, , 04-03, Volume: 8, Issue:2, 2017
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.Proceedings of the National Academy of Sciences of the United States of America, , 02-07, Volume: 114, Issue:6, 2017
Investigation of the effects of carbon-based nanomaterials on A53T alpha-synuclein aggregation using a whole-cell recombinant biosensor.International journal of nanomedicine, , Volume: 12, 2017
Impulse control disorder, lysosomal malfunction and ATP13A2 insufficiency in Parkinsonism.Clinical and experimental pharmacology & physiology, , Volume: 44, Issue:2, 2017
Expression of the Parkinson's Disease-Associated Gene Alpha-Synuclein is Regulated by the Neuronal Cell Fate Determinant TRIM32.Molecular neurobiology, , Volume: 54, Issue:6, 2017
Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models.Proceedings of the National Academy of Sciences of the United States of America, , 03-07, Volume: 114, Issue:10, 2017
Sirtuins as modifiers of Parkinson's disease pathology.Journal of neuroscience research, , Volume: 95, Issue:4, 2017
Nucleobindin 1 binds to multiple types of pre-fibrillar amyloid and inhibits fibrillization.Scientific reports, , 02-21, Volume: 7, 2017
Targeting α-Synuclein as a therapy for Parkinson's disease: The battle begins.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:2, 2017
Whether the dissociation between toxicity and α-synuclein inclusion will be a possible therapy for Parkinson's disease or not?Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:2, 2017
A Human Neural Crest Stem Cell-Derived Dopaminergic Neuronal Model Recapitulates Biochemical Abnormalities in GBA1 Mutation Carriers.Stem cell reports, , 03-14, Volume: 8, Issue:3, 2017
α-Synuclein-carrying extracellular vesicles in Parkinson's disease: deadly transmitters.Acta neurologica Belgica, , Volume: 117, Issue:1, 2017
New evidence comes to light: How is α-synuclein aggregation related to mitochondrial protein import in Parkinson's disease?Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:1, 2017
Selective neuronal vulnerability in Parkinson disease.Nature reviews. Neuroscience, , 01-20, Volume: 18, Issue:2, 2017
Expanding role of molecular chaperones in regulating α-synuclein misfolding; implications in Parkinson's disease.Cellular and molecular life sciences : CMLS, , Volume: 74, Issue:4, 2017
Neuropathology of PARK14 is identical to idiopathic Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:5, 2017
Common structural features of toxic intermediates from α-synuclein and GroES fibrillogenesis detected using cryogenic coherent X-ray diffraction imaging.Journal of biochemistry, , Volume: 161, Issue:1, 2017
Analysis of sheep α-synuclein provides a molecular strategy for the reduction of fibrillation.Biochimica et biophysica acta. Proteins and proteomics, , Volume: 1865, Issue:3, 2017
Behavior of α-synuclein-drug complexes during nanopore analysis with a superimposed AC field.Electrophoresis, , Volume: 38, Issue:2, 2017
Autophagic modulation by rosuvastatin prevents rotenone-induced neurotoxicity in an in vitro model of Parkinson's disease.Neuroscience letters, , 03-06, Volume: 642, 2017
The yin and yang of α-synuclein-associated epigenetics in Parkinson's disease.Brain : a journal of neurology, , Apr-01, Volume: 140, Issue:4, 2017
[Disease-Modifying Therapy for Parkinson's Disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 69, Issue:2, 2017
Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.Disease models & mechanisms, , 05-01, Volume: 10, Issue:5, 2017
In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons.Cell systems, , 02-22, Volume: 4, Issue:2, 2017
The LRRK2-macroautophagy axis and its relevance to Parkinson's disease.Biochemical Society transactions, , 02-08, Volume: 45, Issue:1, 2017
TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation.Proceedings of the National Academy of Sciences of the United States of America, , 02-28, Volume: 114, Issue:9, 2017
ER Stress Induced by Tunicamycin Triggers α-Synuclein Oligomerization, Dopaminergic Neurons Death and Locomotor Impairment: a New Model of Parkinson's Disease.Molecular neurobiology, , Volume: 54, Issue:8, 2017
Challenging drug target for Parkinson's disease: Pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins.Biochimica et biophysica acta. Molecular basis of disease, , Volume: 1863, Issue:1, 2017
α-synuclein aggregation and its modulation.International journal of biological macromolecules, , Volume: 100, 2017
Mulberry fruit ameliorates Parkinson's-disease-related pathology by reducing α-synuclein and ubiquitin levels in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model.The Journal of nutritional biochemistry, , Volume: 39, 2017
Finding the 'Guilty' Gene Variant of Sporadic Parkinson's Disease Via CRISPR/Cas9.Neuroscience bulletin, , Volume: 33, Issue:1, 2017
Epidemiology, environmental risk factors and genetics of Parkinson's disease.Presse medicale (Paris, France : 1983), , Volume: 46, Issue:2 Pt 1, 2017
Laminar degeneration of frontal and temporal cortex in Parkinson disease dementia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 38, Issue:4, 2017
Oligomeric α-synuclein and glucocerebrosidase activity levels in GBA-associated Parkinson's disease.Neuroscience letters, , 01-01, Volume: 636, 2017
Modulation of Parkinson's Disease Associated Protein Rescues Alzheimer's Disease Degeneration.Journal of Alzheimer's disease : JAD, , Volume: 55, Issue:1, 2017
Dermal phospho-alpha-synuclein deposits confirm REM sleep behaviour disorder as prodromal Parkinson's disease.Acta neuropathologica, , Volume: 133, Issue:4, 2017
α-Synuclein in the colon and premotor markers of Parkinson disease in neurologically normal subjects.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 38, Issue:1, 2017
Protein aggregation and neurodegeneration in prototypical neurodegenerative diseases: Examples of amyloidopathies, tauopathies and synucleinopathies.Progress in neurobiology, , Volume: 155, 2017
Synucleinopathies: common features and hippocampal manifestations.Cellular and molecular life sciences : CMLS, , Volume: 74, Issue:8, 2017
Hypomethylation of intron1 of α-synuclein gene does not correlate with Parkinson's disease.Molecular brain, , 02-07, Volume: 10, Issue:1, 2017
Impact of high cholesterol in a Parkinson's disease model: Prevention of lysosomal leakage versus stimulation of α-synuclein aggregation.European journal of cell biology, , Volume: 96, Issue:2, 2017
SNCA mutation p.Ala53Glu is derived from a common founder in the Finnish population.Neurobiology of aging, , Volume: 50, 2017
Lack of RAB39B mutations in early-onset and familial Parkinson's disease in a Taiwanese cohort.Neurobiology of aging, , Volume: 50, 2017
Treatments and compositions targeting α-synuclein: a patent review (2010-2016).Expert opinion on therapeutic patents, , Volume: 27, Issue:4, 2017
Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing.Genome biology, , 01-30, Volume: 18, Issue:1, 2017
Evidence for Intramolecular Antiparallel Beta-Sheet Structure in Alpha-Synuclein Fibrils from a Combination of Two-Dimensional Infrared Spectroscopy and Atomic Force Microscopy.Scientific reports, , 01-23, Volume: 7, 2017
Modelling idiopathic Parkinson disease as a complex illness can inform incidence rate in healthy adults: the PThe European journal of neuroscience, , Volume: 45, Issue:1, 2017
α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies.Nature medicine, , Feb-07, Volume: 23, Issue:2, 2017
An order in Lewy body disorders: Retrograde degeneration in hyperbranching axons as a fundamental structural template accounting for focal/multifocal Lewy body disease.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 37, Issue:2, 2017
Antibodies against the C-terminus of α-synuclein modulate its fibrillation.Biophysical chemistry, , Volume: 220, 2017
Pathological α-synuclein exacerbates the progression of Parkinson's disease through microglial activation.Toxicology letters, , Jan-04, Volume: 265, 2017
Stimulation of synaptoneurosome glutamate release by monomeric and fibrillated α-synuclein.Journal of neuroscience research, , Volume: 95, Issue:9, 2017
Alpha-synuclein and iron: two keys unlocking Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 124, Issue:8, 2017
Aging modifies the effect of GCH1 RS11158026 on DAT uptake and Parkinson's disease clinical severity.Neurobiology of aging, , Volume: 50, 2017
Nicotine slows down oligomerisation of α-synuclein and ameliorates cytotoxicity in a yeast model of Parkinson's disease.Biochimica et biophysica acta. Molecular basis of disease, , Volume: 1863, Issue:6, 2017
Relationship between the plasma levels of neurodegenerative proteins and motor subtypes of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 124, Issue:3, 2017
Toll-like receptor 2 is increased in neurons in Parkinson's disease brain and may contribute to alpha-synuclein pathology.Acta neuropathologica, , Volume: 133, Issue:2, 2017
Hypothalamic α-synuclein and its relation to weight loss and autonomic symptoms in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:2, 2017
Biochemical analysis of α-synuclein extracted from control and Parkinson's disease colonic biopsies.Neuroscience letters, , 02-22, Volume: 641, 2017
Toxic effects of human and rodent variants of alpha-synuclein in vivo.The European journal of neuroscience, , Volume: 45, Issue:4, 2017
Copy number variability in Parkinson's disease: assembling the puzzle through a systems biology approach.Human genetics, , Volume: 136, Issue:1, 2017
Robust graft survival and normalized dopaminergic innervation do not obligate recovery in a Parkinson disease patient.Annals of neurology, , Volume: 81, Issue:1, 2017
Comparison of neuropathology in Parkinson's disease subjects with and without deep brain stimulation.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:2, 2017
D-Ala2-GIP-glu-PAL is neuroprotective in a chronic Parkinson's disease mouse model and increases BNDF expression while reducing neuroinflammation and lipid peroxidation.European journal of pharmacology, , Feb-15, Volume: 797, 2017
Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders.Pharmacology & therapeutics, , Volume: 172, 2017
Differential copper binding to alpha-synuclein and its disease-associated mutants affect the aggregation and amyloid formation.Biochimica et biophysica acta. General subjects, , Volume: 1861, Issue:2, 2017
Conformation-Specific Detection of α-Synuclein: The Search for a Biomarker in Parkinson Disease.JAMA neurology, , 02-01, Volume: 74, Issue:2, 2017
Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid.JAMA neurology, , Feb-01, Volume: 74, Issue:2, 2017
Extracts from two ubiquitous Mediterranean plants ameliorate cellular and animal models of neurodegenerative proteinopathies.Neuroscience letters, , 01-18, Volume: 638, 2017
The effect of α-synuclein on gliosis and IL-1α, TNFα, IFNγ, TGFβ expression in murine brain.Pharmacological reports : PR, , Volume: 69, Issue:2, 2017
The Transcellular Propagation and Intracellular Trafficking of α-Synuclein.Cold Spring Harbor perspectives in medicine, , Sep-01, Volume: 7, Issue:9, 2017
Early and progressive microstructural brain changes in mice overexpressing human α-Synuclein detected by diffusion kurtosis imaging.Brain, behavior, and immunity, , Volume: 61, 2017
Auxilin Underlies Progressive Locomotor Deficits and Dopaminergic Neuron Loss in a Drosophila Model of Parkinson's Disease.Cell reports, , 01-31, Volume: 18, Issue:5, 2017
The FBXO7 homologue nutcracker and binding partner PI31 in Drosophila melanogaster models of Parkinson's disease.Genome, , Volume: 60, Issue:1, 2017
Nurr1 overexpression exerts neuroprotective and anti-inflammatory roles via down-regulating CCL2 expression in both in vivo and in vitro Parkinson's disease models.Biochemical and biophysical research communications, , Jan-22, Volume: 482, Issue:4, 2017
Effects of α-synuclein on axonal transport.Neurobiology of disease, , Volume: 105, 2017
MicroRNA expressing profiles in A53T mutant alpha-synuclein transgenic mice and Parkinsonian.Oncotarget, , Jan-03, Volume: 8, Issue:1, 2017
Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis.The Lancet. Neurology, , Volume: 16, Issue:1, 2017
Early start of progressive motor deficits in Line 61 α-synuclein transgenic mice.BMC neuroscience, , 01-31, Volume: 18, Issue:1, 2017
Bilateral upregulation of α-synuclein expression in the mouse substantia nigra by intracranial rotenone treatment.Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, , Volume: 69, Issue:2, 2017
Nrf2 mitigates LRRK2- and α-synuclein-induced neurodegeneration by modulating proteostasis.Proceedings of the National Academy of Sciences of the United States of America, , 01-31, Volume: 114, Issue:5, 2017
[Neuropathology and pathophysiology of Parkinson's disease: Focus on α-synuclein].Presse medicale (Paris, France : 1983), , Volume: 46, Issue:2 Pt 1, 2017
LTB-Syn: a recombinant immunogen for the development of plant-made vaccines against synucleinopathies.Planta, , Volume: 245, Issue:6, 2017
An alpha-synuclein MRM assay with diagnostic potential for Parkinson's disease and monitoring disease progression.Proteomics. Clinical applications, , Volume: 11, Issue:7-8, 2017
Structural variants in SNCA gene and the implication to synucleinopathies.Current opinion in genetics & development, , Volume: 44, 2017
Association between gene polymorphism and depression in Parkinson's disease: A case-control study.Journal of the neurological sciences, , Apr-15, Volume: 375, 2017
Lewy Bodies and the Mechanisms of Neuronal Cell Death in Parkinson's Disease and Dementia with Lewy Bodies.Brain pathology (Zurich, Switzerland), , Volume: 27, Issue:1, 2017
DJ-1, a Parkinson's disease related protein, aggregates under denaturing conditions and co-aggregates with α-synuclein through hydrophobic interaction.Biochimica et biophysica acta. General subjects, , Volume: 1861, Issue:7, 2017
Decrease in Aβ42 predicts dopa-resistant gait progression in early Parkinson disease.Neurology, , Apr-18, Volume: 88, Issue:16, 2017
Parkinson disease.Nature reviews. Disease primers, , Mar-23, Volume: 3, 2017
MOAG-4 promotes the aggregation of α-synuclein by competing with self-protective electrostatic interactions.The Journal of biological chemistry, , 05-19, Volume: 292, Issue:20, 2017
α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt CaActa neuropathologica, , Volume: 134, Issue:1, 2017
Interaction of LRRK2 and α-Synuclein in Parkinson's Disease.Advances in neurobiology, , Volume: 14, 2017
The Systemic Synuclein Sampling Study: toward a biomarker for Parkinson's disease.Biomarkers in medicine, , Volume: 11, Issue:4, 2017
Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage.Human molecular genetics, , 06-15, Volume: 26, Issue:12, 2017
Disparate genes come together: Spatial and genetic screens point to disruptions in vesicle trafficking and mRNA metabolism in synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:6, 2017
Motor deficits and beta oscillations are dissociable in an alpha-synuclein model of Parkinson's disease.The European journal of neuroscience, , Volume: 46, Issue:3, 2017
A sensitive assay reveals structural requirements for α-synuclein fibril growth.The Journal of biological chemistry, , 06-02, Volume: 292, Issue:22, 2017
A novel tool for monitoring endogenous alpha-synuclein transcription by NanoLuciferase tag insertion at the 3'end using CRISPR-Cas9 genome editing technique.Scientific reports, , 04-04, Volume: 8, 2017
Lack of spontaneous age-related brain pathology in Octodon degus: a reappraisal of the model.Scientific reports, , 04-04, Volume: 7, 2017
Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson's disease.Neuropathology and applied neurobiology, , Volume: 43, Issue:7, 2017
Inhibition by Multifunctional Magnetic Nanoparticles Loaded with Alpha-Synuclein RNAi Plasmid in a Parkinson's Disease Model.Theranostics, , Volume: 7, Issue:2, 2017
Spine Topographical Distribution of Skin α-Synuclein Deposits in Idiopathic Parkinson Disease.Journal of neuropathology and experimental neurology, , May-01, Volume: 76, Issue:5, 2017
Ubiquitin and Parkinson's disease through the looking glass of genetics.The Biochemical journal, , 04-13, Volume: 474, Issue:9, 2017
SNCA 3'UTR genetic variants in patients with Parkinson's disease and REM sleep behavior disorder.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 38, Issue:7, 2017
In vitro α-synuclein neurotoxicity and spreading among neurons and astrocytes using Lewy body extracts from Parkinson disease brains.Neurobiology of disease, , Volume: 103, 2017
Derivation of mouse embryonic stem cell lines from tyrosine hydroxylase reporter mice crossed with a human SNCA transgenic mouse model of Parkinson's disease.Stem cell research, , Volume: 19, 2017
Defective synaptic connectivity and axonal neuropathology in a human iPSC-based model of familial Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 05-02, Volume: 114, Issue:18, 2017
Lewy pathological study on α-synuclein in gastrointestinal tissues of prodromal Parkinson's disease.European review for medical and pharmacological sciences, , Volume: 21, Issue:7, 2017
Imaging genetics approach to Parkinson's disease and its correlation with clinical score.Scientific reports, , 04-21, Volume: 7, 2017
Evidence from spatial pattern analysis for the anatomical spread of α-synuclein pathology in Parkinson's disease dementia.Folia neuropathologica, , Volume: 55, Issue:1, 2017
Genetic analysis of α-synuclein 3' untranslated region and its corresponding microRNAs in relation to Parkinson's disease compared to dementia with Lewy bodies.Alzheimer's & dementia : the journal of the Alzheimer's Association, , Volume: 13, Issue:11, 2017
Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.Neurochemistry international, , Volume: 109, 2017
Involvement of the cerebellum in Parkinson disease and dementia with Lewy bodies.Annals of neurology, , Volume: 81, Issue:6, 2017
Deregulation of α-synuclein in Parkinson's disease: Insight from epigenetic structure and transcriptional regulation of SNCA.Progress in neurobiology, , Volume: 154, 2017
Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage.Molecular and cellular neurosciences, , Volume: 82, 2017
Parkinson disease: Antibodies reveal age of Lewy pathology in PD.Nature reviews. Neurology, , Volume: 13, Issue:6, 2017
TMEM230 in Parkinson's disease.Neurobiology of aging, , Volume: 56, 2017
Novel Benzothiazole Derivatives as Fluorescent Probes for Detection of β-Amyloid and α-Synuclein Aggregates.ACS chemical neuroscience, , 08-16, Volume: 8, Issue:8, 2017
Subthalamic nucleus deep brain stimulation is neuroprotective in the A53T α-synuclein Parkinson's disease rat model.Annals of neurology, , Volume: 81, Issue:6, 2017
Expression signatures of long non-coding RNA in the substantia nigra of pre-symptomatic mouse model of Parkinson's disease.Behavioural brain research, , 07-28, Volume: 331, 2017
The critical role of Nramp1 in degrading α-synuclein oligomers in microglia under iron overload condition.Neurobiology of disease, , Volume: 104, 2017
The Contribution of Neural plasticity, , Volume: 2017, 2017
Higher levels of myelin phospholipids in brains of neuronal α-Synuclein transgenic mice precede myelin loss.Acta neuropathologica communications, , 05-08, Volume: 5, Issue:1, 2017
Mutant α-Synuclein Overexpression Induces Stressless Pacemaking in Vagal Motoneurons at Risk in Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 01-04, Volume: 37, Issue:1, 2017
Enteric alpha-synuclein pathology in LRRK2-G2019S Parkinson's disease.Parkinsonism & related disorders, , Volume: 40, 2017
O-GlcNAc modification inhibits the calpain-mediated cleavage of α-synuclein.Bioorganic & medicinal chemistry, , 09-15, Volume: 25, Issue:18, 2017
High expression levels of the D686N Parkinson's disease mutation in VPS35 induces α-synuclein-dependent toxicity in yeast.Molecular medicine reports, , Volume: 16, Issue:1, 2017
Validation of electrochemiluminescence assays for highly sensitive and reproducible quantification of α-synuclein in cerebrospinal fluid.Bioanalysis, , Volume: 9, Issue:8, 2017
Survival and Causes of Death Among People With Clinically Diagnosed Synucleinopathies With Parkinsonism: A Population-Based Study.JAMA neurology, , 07-01, Volume: 74, Issue:7, 2017
Distinct pattern of enteric phospho-alpha-synuclein aggregates and gene expression profiles in patients with Parkinson's disease.Acta neuropathologica communications, , 01-05, Volume: 5, Issue:1, 2017
Glucocerebrosidase deficiency in dopaminergic neurons induces microglial activation without neurodegeneration.Human molecular genetics, , 07-15, Volume: 26, Issue:14, 2017
Alpha-Synuclein mRNA Is Not Increased in Sporadic PD and Alpha-Synuclein Accumulation Does Not Block GDNF Signaling in Parkinson's Disease and Disease Models.Molecular therapy : the journal of the American Society of Gene Therapy, , 10-04, Volume: 25, Issue:10, 2017
Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 06-14, Volume: 37, Issue:24, 2017
Cellular models as tools for the study of the role of alpha-synuclein in Parkinson's disease.Experimental neurology, , Volume: 298, Issue:Pt B, 2017
Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins.Acta neuropathologica, , Volume: 134, Issue:4, 2017
Treadmill exercise produces neuroprotective effects in a murine model of Parkinson's disease by regulating the TLR2/MyD88/NF-κB signaling pathway.Neuroscience, , 07-25, Volume: 356, 2017
Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production.Cellular and molecular life sciences : CMLS, , Volume: 74, Issue:15, 2017
Membrane Trafficking Illuminates a Path to Parkinson's Disease.The Tohoku journal of experimental medicine, , Volume: 242, Issue:1, 2017
Structural genomic variations and Parkinson's disease.Minerva medica, , Volume: 108, Issue:5, 2017
Tau/α-synuclein ratio and inflammatory proteins in Parkinson's disease: An exploratory study.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:7, 2017
Plasma α-synuclein predicts cognitive decline in Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry, , Volume: 88, Issue:10, 2017
AlphaLISA detection of alpha-synuclein in the cerebrospinal fluid and its potential application in Parkinson's disease diagnosis.Protein & cell, , Volume: 8, Issue:9, 2017
Zeroing in on neurodegenerative α-synuclein.Nature reviews. Drug discovery, , 05-31, Volume: 16, Issue:6, 2017
Cystatin C as a potential therapeutic mediator against Parkinson's disease via VEGF-induced angiogenesis and enhanced neuronal autophagy in neurovascular units.Cell death & disease, , 06-01, Volume: 8, Issue:6, 2017
Mesenchymal Stem Cells Stabilize Axonal Transports for Autophagic Clearance of α-Synuclein in Parkinsonian Models.Stem cells (Dayton, Ohio), , Volume: 35, Issue:8, 2017
Cutaneous Alpha-Synuclein From Paraffin Embedded Autopsy Specimens in Parkinson's Disease.Journal of Parkinson's disease, , Volume: 7, Issue:3, 2017
Treatment with diphenyl-pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death.Proceedings of the National Academy of Sciences of the United States of America, , 06-20, Volume: 114, Issue:25, 2017
Modeling Parkinson's disease with induced pluripotent stem cells harboring α-synuclein mutations.Brain pathology (Zurich, Switzerland), , Volume: 27, Issue:4, 2017
Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson's disease.Molecular neurodegeneration, , 06-07, Volume: 12, Issue:1, 2017
Spinal cord stimulation improves forelimb use in an alpha-synuclein animal model of Parkinson's disease.The International journal of neuroscience, , Volume: 127, Issue:1, 2017
Autoimmune antibody decline in Parkinson's disease and Multiple System Atrophy; a step towards immunotherapeutic strategies.Molecular neurodegeneration, , 06-07, Volume: 12, Issue:1, 2017
Discovery, validation and optimization of cerebrospinal fluid biomarkers for use in Parkinson's disease.Expert review of molecular diagnostics, , Volume: 17, Issue:8, 2017
A loss of Pdxk model of Parkinson disease in Drosophila can be suppressed by Buffy.BMC research notes, , Jun-12, Volume: 10, Issue:1, 2017
Novel evidence associates higher plasma α-synuclein levels and cognitive impairment in Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry, , Volume: 88, Issue:10, 2017
Design, synthesis, immunocytochemistry evaluation, and molecular docking investigation of several 4-aminopyridine derivatives as potential neuroprotective agents for treating Parkinson's disease.Bioorganic chemistry, , Volume: 73, 2017
The implication of neuronimmunoendocrine (NIE) modulatory network in the pathophysiologic process of Parkinson's disease.Cellular and molecular life sciences : CMLS, , Volume: 74, Issue:20, 2017
Pressure effects on α-synuclein amyloid fibrils: An experimental investigation on their dissociation and reversible nature.Archives of biochemistry and biophysics, , 08-01, Volume: 627, 2017
Striatal changes underlie MPEP-mediated suppression of the acquisition and expression of pramipexole-induced place preference in an alpha-synuclein rat model of Parkinson's disease.Journal of psychopharmacology (Oxford, England), , Volume: 31, Issue:10, 2017
α-Synuclein aggregation modulation: an emerging approach for the treatment of Parkinson's disease.Future medicinal chemistry, , Volume: 9, Issue:10, 2017
Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson's disease.Scientific reports, , 06-20, Volume: 7, Issue:1, 2017
T cells from patients with Parkinson's disease recognize α-synuclein peptides.Nature, , 06-29, Volume: 546, Issue:7660, 2017
Familial Mutations and Post-translational Modifications of UCH-L1 in Parkinson's Disease and Neurodegenerative Disorders.Current protein & peptide science, , Volume: 18, Issue:7, 2017
CADPS2 gene expression is oppositely regulated by LRRK2 and alpha-synuclein.Biochemical and biophysical research communications, , 08-26, Volume: 490, Issue:3, 2017
Expression of Aquaporin 1 and Aquaporin 4 in the Temporal Neocortex of Patients with Parkinson's Disease.Brain pathology (Zurich, Switzerland), , Volume: 27, Issue:2, 2017
A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity.Journal of innate immunity, , Volume: 9, Issue:5, 2017
Homozygous alpha-synuclein p.A53V in familial Parkinson's disease.Neurobiology of aging, , Volume: 57, 2017
Brain infusion of α-synuclein oligomers induces motor and non-motor Parkinson's disease-like symptoms in mice.Behavioural brain research, , 08-30, Volume: 333, 2017
The Role of Lipids Interacting with α-Synuclein in the Pathogenesis of Parkinson's Disease.Journal of Parkinson's disease, , Volume: 7, Issue:3, 2017
Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease.Nature structural & molecular biology, , Volume: 24, Issue:8, 2017
Treadmill exercise alleviates motor deficits and improves mitochondrial import machinery in an MPTP-induced mouse model of Parkinson's disease.Experimental gerontology, , Volume: 89, 2017
Parkinson's disease; the hibernating spore hypothesis.Medical hypotheses, , Volume: 104, 2017
Parkinson's Disease: Basic Pathomechanisms and a Clinical Overview.Advances in neurobiology, , Volume: 15, 2017
Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy.Molecular neurodegeneration, , 07-04, Volume: 12, Issue:1, 2017
Alpha-Synuclein Disease Mutations Are Structurally Defective and Locally Affect Membrane Binding.Journal of the American Chemical Society, , 03-29, Volume: 139, Issue:12, 2017
Physico-Pathologic Mechanisms Involved in Neurodegeneration: Misfolded Protein-Plasma Membrane Interactions.Neuron, , Jul-05, Volume: 95, Issue:1, 2017
LRRK2 and Parkinson's Disease: From Lack of Structure to Gain of Function.Current protein & peptide science, , Volume: 18, Issue:7, 2017
Imaging neuroinflammation to monitor α-synucleinopathy.The Lancet. Neurology, , Volume: 16, Issue:10, 2017
Role of Apolipoproteins and α-Synuclein in Parkinson's Disease.Journal of molecular neuroscience : MN, , Volume: 62, Issue:3-4, 2017
Neuroprotective effect of α-mangostin on mitochondrial dysfunction and α-synuclein aggregation in rotenone-induced model of Parkinson's disease in differentiated SH-SY5Y cells.Journal of Asian natural products research, , Volume: 19, Issue:8, 2017
αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson's disease.Scientific reports, , 07-11, Volume: 7, Issue:1, 2017
Secretory carrier membrane protein 5 is an autophagy inhibitor that promotes the secretion of α-synuclein via exosome.PloS one, , Volume: 12, Issue:7, 2017
A pH-dependent switch promotes β-synuclein fibril formation via glutamate residues.The Journal of biological chemistry, , 09-29, Volume: 292, Issue:39, 2017
Involvement of Gaucher Disease Mutations in Parkinson Disease.Current protein & peptide science, , Volume: 18, Issue:7, 2017
The Cleavage Effect of Mesenchymal Stem Cell and Its Derived Matrix Metalloproteinase-2 on Extracellular α-Synuclein Aggregates in Parkinsonian Models.Stem cells translational medicine, , Volume: 6, Issue:3, 2017
A unique glycan-isoform of transferrin in cerebrospinal fluid: A potential diagnostic marker for neurological diseases.Biochimica et biophysica acta. General subjects, , Volume: 1861, Issue:10, 2017
The Golgi-localized, gamma ear-containing, ARF-binding (GGA) protein family alters alpha synuclein (α-syn) oligomerization and secretion.Aging, , 07-15, Volume: 9, Issue:7, 2017
O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson's disease.Molecular brain, , 07-19, Volume: 10, Issue:1, 2017
α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading.Acta neuropathologica, , Volume: 134, Issue:5, 2017
A user's guide for α-synuclein biomarker studies in biological fluids: Perianalytical considerations.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:8, 2017
Alteration of Structure and Aggregation of α-Synuclein by Familial Parkinson's Disease Associated Mutations.Current protein & peptide science, , Volume: 18, Issue:7, 2017
New Therapeutic Strategies for Lewy Body Dementias.Current neurology and neuroscience reports, , Volume: 17, Issue:9, 2017
Early synaptic dysfunction induced by α-synuclein in a rat model of Parkinson's disease.Scientific reports, , 07-25, Volume: 7, Issue:1, 2017
Parkinsonian features in aging GFAP.HMOX1 transgenic mice overexpressing human HO-1 in the astroglial compartment.Neurobiology of aging, , Volume: 58, 2017
Animal models of α-synucleinopathy for Parkinson disease drug development.Nature reviews. Neuroscience, , Volume: 18, Issue:9, 2017
Differential role of CSF fatty acid binding protein 3, α-synuclein, and Alzheimer's disease core biomarkers in Lewy body disorders and Alzheimer's dementia.Alzheimer's research & therapy, , Jul-28, Volume: 9, Issue:1, 2017
Small-Molecule-Induced Soluble Oligomers of α-Synuclein with Helical Structure.Chemistry (Weinheim an der Bergstrasse, Germany), , Sep-21, Volume: 23, Issue:53, 2017
Experimental animal models of Parkinson's disease: A transition from assessing symptomatology to α-synuclein targeted disease modification.Experimental neurology, , Volume: 298, Issue:Pt B, 2017
Cerebrospinal fluid biomarkers for Parkinson's disease - a systematic review.Acta neurologica Scandinavica, , Volume: 135, Issue:1, 2017
Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation.Journal of neuroinflammation, , 08-02, Volume: 14, Issue:1, 2017
A meta-analysis and review examining a possible role for oxidative stress and singlet oxygen in diverse diseases.The Biochemical journal, , 08-02, Volume: 474, Issue:16, 2017
Homologous HSV1 and alpha-synuclein peptides stimulate a T cell response in Parkinson's disease.Journal of neuroimmunology, , 09-15, Volume: 310, 2017
Alpha-synuclein triggers T-cell response. Is Parkinson's disease an autoimmune disorder?Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:9, 2017
Preclinical development of a vaccine against oligomeric alpha-synuclein based on virus-like particles.PloS one, , Volume: 12, Issue:8, 2017
Aggregation of α-Synuclein in the Gonadal Tissue of 2 Patients With Parkinson Disease.JAMA neurology, , 05-01, Volume: 74, Issue:5, 2017
Alpha-synuclein oligomers: a new hope.Acta neuropathologica, , Volume: 134, Issue:6, 2017
Alpha-synuclein ferrireductase activity is detectible in vivo, is altered in Parkinson's disease and increases the neurotoxicity of DOPAL.Molecular and cellular neurosciences, , Volume: 85, 2017
A Systems Model of Parkinson's Disease Using Biochemical Systems Theory.Omics : a journal of integrative biology, , Volume: 21, Issue:8, 2017
Bioinorganic Chemistry of Parkinson's Disease: Affinity and Structural Features of Cu(I) Binding to the Full-Length β-Synuclein Protein.Inorganic chemistry, , Sep-05, Volume: 56, Issue:17, 2017
Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson's disease.Journal of neuroinflammation, , Aug-18, Volume: 14, Issue:1, 2017
Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages.Scientific reports, , 08-21, Volume: 7, Issue:1, 2017
Epigenetic approach to early-onset Parkinson's disease: low methylation status of SNCA and PARK2 promoter regions.Neurological research, , Volume: 39, Issue:11, 2017
α-Synuclein promotes dilation of the exocytotic fusion pore.Nature neuroscience, , Volume: 20, Issue:5, 2017
Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils.Redox biology, , Volume: 11, 2017
Cerebrospinal fluid β-glucocerebrosidase activity is reduced in parkinson's disease patients.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:10, 2017
Association between SNCA rs2736990 polymorphism and Parkinson's disease: a meta-analysis.Neuroscience letters, , Sep-29, Volume: 658, 2017
In utero delivery of rAAV2/9 induces neuronal expression of the transgene in the brain: towards new models of Parkinson's disease.Gene therapy, , Volume: 24, Issue:12, 2017
α-Synucleinopathy in the Human Amygdala in Parkinson Disease: Differential Vulnerability of Somatostatin- and Parvalbumin-Expressing Neurons.Journal of neuropathology and experimental neurology, , Sep-01, Volume: 76, Issue:9, 2017
The Birth of the Modern Era of Parkinson's Disease Genetics.Journal of Parkinson's disease, , Volume: 7, Issue:s1, 2017
β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson's disease.Science (New York, N.Y.), , 09-01, Volume: 357, Issue:6354, 2017
The Medicinal Chemistry of Natural and Semisynthetic Compounds against Parkinson's and Huntington's Diseases.ACS chemical neuroscience, , 11-15, Volume: 8, Issue:11, 2017
Effects of small-molecule amyloid modulators on a Drosophila model of Parkinson's disease.PloS one, , Volume: 12, Issue:9, 2017
Discoidin domain receptor inhibition reduces neuropathology and attenuates inflammation in neurodegeneration models.Journal of neuroimmunology, , 10-15, Volume: 311, 2017
Alpha-Synuclein to the Rescue: Immune Cell Recruitment by Alpha-Synuclein during Gastrointestinal Infection.Journal of innate immunity, , Volume: 9, Issue:5, 2017
The Synucleinopathies: Twenty Years On.Journal of Parkinson's disease, , Volume: 7, Issue:s1, 2017
Vaccination strategies in tauopathies and synucleinopathies.Journal of neurochemistry, , Volume: 143, Issue:5, 2017
The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome.PloS one, , Volume: 12, Issue:9, 2017
Diagnostic utility of cerebrospinal fluid α-synuclein in Parkinson's disease: A systematic review and meta-analysis.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:10, 2017
Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease.Science (New York, N.Y.), , 09-22, Volume: 357, Issue:6357, 2017
Mitochondrial dynamics in Parkinson's disease: a role for α-synuclein?Disease models & mechanisms, , 09-01, Volume: 10, Issue:9, 2017
The Identification of Alpha-Synuclein as the First Parkinson Disease Gene.Journal of Parkinson's disease, , Volume: 7, Issue:s1, 2017
REM sleep behavior disorder is related to enteric neuropathology in Parkinson disease.Neurology, , Oct-10, Volume: 89, Issue:15, 2017
Modeling Parkinson's disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain.Proceedings of the National Academy of Sciences of the United States of America, , 09-26, Volume: 114, Issue:39, 2017
Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson's disease?Acta neuropathologica communications, , 09-13, Volume: 5, Issue:1, 2017
Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells.Human molecular genetics, , 09-15, Volume: 26, Issue:18, 2017
Parkinson disease: Asthma drug could protect against PD.Nature reviews. Neurology, , Volume: 13, Issue:11, 2017
Beyond L-DOPA: hope for Parkinson's treatment and diagnosis.EBioMedicine, , Volume: 23, 2017
Fundamental limit of alpha-synuclein pathology in gastrointestinal biopsy as a pathologic biomarker of Parkinson's disease: Comparison with surgical specimens.Parkinsonism & related disorders, , Volume: 44, 2017
Insights into the structural biology of Gaucher disease.Experimental neurology, , Volume: 298, Issue:Pt B, 2017
TrkB neurotrophic activities are blocked by α-synuclein, triggering dopaminergic cell death in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 10-03, Volume: 114, Issue:40, 2017
Age-Dependent Alpha-Synuclein Accumulation and Phosphorylation in the Enteric Nervous System in a Transgenic Mouse Model of Parkinson's Disease.Neuroscience bulletin, , Volume: 33, Issue:5, 2017
Loss of MicroRNA-7 Regulation Leads to α-Synuclein Accumulation and Dopaminergic Neuronal Loss In Vivo.Molecular therapy : the journal of the American Society of Gene Therapy, , 10-04, Volume: 25, Issue:10, 2017
NCEH-1 modulates cholesterol metabolism and protects against α-synuclein toxicity in a C. elegans model of Parkinson's disease.Human molecular genetics, , 10-01, Volume: 26, Issue:19, 2017
Mechanisms of Parkinson's disease-related proteins in mediating secondary brain damage after cerebral ischemia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 37, Issue:6, 2017
Proteasome impairment by α-synuclein.PloS one, , Volume: 12, Issue:9, 2017
Absence of SNCA polymorphisms in Pakistani Parkinsons disease patients.JPMA. The Journal of the Pakistan Medical Association, , Volume: 67, Issue:10, 2017
Getting in charge of β-synuclein fibrillation.The Journal of biological chemistry, , 09-29, Volume: 292, Issue:39, 2017
The Search for a Peripheral Biopsy Indicator of α-Synuclein Pathology for Parkinson Disease.Journal of neuropathology and experimental neurology, , 01-01, Volume: 76, Issue:1, 2017
C-Terminal Truncated α-Synuclein Fibrils Contain Strongly Twisted β-Sheets.Journal of the American Chemical Society, , 11-01, Volume: 139, Issue:43, 2017
A ventral glomerular deficit in Parkinson's disease revealed by whole olfactory bulb reconstruction.Brain : a journal of neurology, , Oct-01, Volume: 140, Issue:10, 2017
Alpha-synuclein induces the unfolded protein response in Parkinson's disease SNCA triplication iPSC-derived neurons.Human molecular genetics, , 11-15, Volume: 26, Issue:22, 2017
Is trehalose an autophagic inducer? Unraveling the roles of non-reducing disaccharides on autophagic flux and alpha-synuclein aggregation.Cell death & disease, , 10-05, Volume: 8, Issue:10, 2017
Randomized CRISPR-Cas Transcriptional Perturbation Screening Reveals Protective Genes against Alpha-Synuclein Toxicity.Molecular cell, , Oct-05, Volume: 68, Issue:1, 2017
Can STN DBS protect both nigral somata and innervation of the striatum?Annals of neurology, , Volume: 82, Issue:5, 2017
Reply to "Can STN DBS protect both nigral somata and innervation of the striatum?"Annals of neurology, , Volume: 82, Issue:5, 2017
Alpha-synuclein, epigenetics, mitochondria, metabolism, calcium traffic, & circadian dysfunction in Parkinson's disease. An integrated strategy for management.Ageing research reviews, , Volume: 40, 2017
Immunochemical Detection of α-Synuclein Autoantibodies in Parkinson's Disease: Correlation between Plasma and Cerebrospinal Fluid Levels.ACS chemical neuroscience, , 06-21, Volume: 8, Issue:6, 2017
Therapeutic approaches to target alpha-synuclein pathology.Experimental neurology, , Volume: 298, Issue:Pt B, 2017
FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling.Stem cell reports, , 11-14, Volume: 9, Issue:5, 2017
α-Synuclein impairs ferritinophagy in the retinal pigment epithelium: Implications for retinal iron dyshomeostasis in Parkinson's disease.Scientific reports, , 10-09, Volume: 7, Issue:1, 2017
Prying into the Prion Hypothesis for Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 10-11, Volume: 37, Issue:41, 2017
Phosphorylated α-synuclein immunoreactivity in nerve fibers from minor salivary glands in Parkinson's disease.Parkinsonism & related disorders, , Volume: 38, 2017
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.PLoS biology, , Volume: 15, Issue:3, 2017
Familial Mutations May Switch Conformational Preferences in α-Synuclein Fibrils.ACS chemical neuroscience, , 04-19, Volume: 8, Issue:4, 2017
Comparison of the in vivo induction and transmission of α-synuclein pathology by mutant α-synuclein fibril seeds in transgenic mice.Human molecular genetics, , 12-15, Volume: 26, Issue:24, 2017
Brain monoamine oxidase B and A in human parkinsonian dopamine deficiency disorders.Brain : a journal of neurology, , Sep-01, Volume: 140, Issue:9, 2017
CCAAT/Enhancer binding protein β silencing mitigates glial activation and neurodegeneration in a rat model of Parkinson's disease.Scientific reports, , 10-19, Volume: 7, Issue:1, 2017
Breathing new life into an old target: pulmonary disease drugs for Parkinson's disease therapy.Genome medicine, , 10-19, Volume: 9, Issue:1, 2017
Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease.Scientific reports, , 10-20, Volume: 7, Issue:1, 2017
High-Throughput Screening Methodology to Identify Alpha-Synuclein Aggregation Inhibitors.International journal of molecular sciences, , Mar-02, Volume: 18, Issue:3, 2017
Synuclein and dopamine: the Bonnie and Clyde of Parkinson's disease.Nature neuroscience, , 10-26, Volume: 20, Issue:11, 2017
Sleep fragmentation and Parkinson's disease pathology in older adults without Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:12, 2017
Eye movements in genetic parkinsonisms affecting the α-synuclein, PARK9, and manganese network.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, , Volume: 128, Issue:12, 2017
Urinary dysfunction in early de novo patients with Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 32, Issue:6, 2017
c-Abl and Parkinson's Disease: Mechanisms and Therapeutic Potential.Journal of Parkinson's disease, , Volume: 7, Issue:4, 2017
Synthesis and biological evaluation of novel radioiodinated benzimidazole derivatives for imaging α-synuclein aggregates.Bioorganic & medicinal chemistry, , 12-15, Volume: 25, Issue:24, 2017
Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles.Scientific reports, , 11-08, Volume: 7, Issue:1, 2017
Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease.Proceedings of the National Academy of Sciences of the United States of America, , 03-14, Volume: 114, Issue:11, 2017
Ferroptosis and cell death mechanisms in Parkinson's disease.Neurochemistry international, , Volume: 104, 2017
Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels.BMC neurology, , Nov-15, Volume: 17, Issue:1, 2017
Discovering the 3' UTR-mediated regulation of alpha-synuclein.Nucleic acids research, , Dec-15, Volume: 45, Issue:22, 2017
Potential Modes of Intercellular α-Synuclein Transmission.International journal of molecular sciences, , Feb-22, Volume: 18, Issue:2, 2017
Anti-Parkinsonian effects of β-amyrin are regulated via LGG-1 involved autophagy pathway in Caenorhabditis elegans.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Dec-01, Volume: 36, 2017
α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration.Acta neuropathologica communications, , Nov-21, Volume: 5, Issue:1, 2017
Morphological analysis of mitochondria for evaluating the toxicity of α-synuclein in transgenic mice and isolated preparations by atomic force microscopy.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 96, 2017
Polyphenols in combination with β-cyclodextrin can inhibit and disaggregate α-synuclein amyloids under cell mimicking conditions: A promising therapeutic alternative.Biochimica et biophysica acta. Proteins and proteomics, , Volume: 1865, Issue:5, 2017
Nanoparticle standards for immuno-based quantitation of α-synuclein oligomers in diagnostics of Parkinson's disease and other synucleinopathies.Clinica chimica acta; international journal of clinical chemistry, , Volume: 466, 2017
SUMOylation and ubiquitination reciprocally regulate α-synuclein degradation and pathological aggregation.Proceedings of the National Academy of Sciences of the United States of America, , 12-12, Volume: 114, Issue:50, 2017
The nonmotor features of Parkinson's disease: pathophysiology and management advances.Current opinion in neurology, , Volume: 29, Issue:4, 2016
Increased copper toxicity in Saccharomyces cerevisiae lacking VPS35, a component of the retromer and monogenic Parkinson disease gene in humans.Biochemical and biophysical research communications, , 08-05, Volume: 476, Issue:4, 2016
Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson's Disease Patients.Cell reports, , 06-14, Volume: 15, Issue:11, 2016
Development of an ultra-high sensitive immunoassay with plasma biomarker for differentiating Parkinson disease dementia from Parkinson disease using antibody functionalized magnetic nanoparticles.Journal of nanobiotechnology, , Jun-08, Volume: 14, Issue:1, 2016
α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease.Science translational medicine, , 06-08, Volume: 8, Issue:342, 2016
A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death.Human molecular genetics, , 07-15, Volume: 25, Issue:14, 2016
Diagnostic utility of CSF α-synuclein species in Parkinson's disease: protocol for a systematic review and meta-analysis.BMJ open, , 06-13, Volume: 6, Issue:6, 2016
Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , 06-28, Volume: 113, Issue:26, 2016
Piceatannol and Other Wine Stilbenes: A Pool of Inhibitors against α-Synuclein Aggregation and Cytotoxicity.Nutrients, , Jun-15, Volume: 8, Issue:6, 2016
Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles.PloS one, , Volume: 11, Issue:6, 2016
Similar α-Synuclein staining in the colon mucosa in patients with Parkinson's disease and controls.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:10, 2016
The rs3857059 variant of the SNCA gene is associated with Parkinson's disease in Mexican Mestizos.Arquivos de neuro-psiquiatria, , Volume: 74, Issue:6, 2016
Salivary total α-synuclein, oligomeric α-synuclein and SNCA variants in Parkinson's disease patients.Scientific reports, , 06-23, Volume: 6, 2016
C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson's Disease.PLoS genetics, , Volume: 12, Issue:6, 2016
Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson's disease.Free radical biology & medicine, , Volume: 97, 2016
Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration.The Journal of clinical investigation, , 08-01, Volume: 126, Issue:8, 2016
Epigallocatechin Gallate (EGCG) Inhibits Alpha-Synuclein Aggregation: A Potential Agent for Parkinson's Disease.Neurochemical research, , Volume: 41, Issue:10, 2016
Exploring the Transition of Human α-Synuclein from Native to the Fibrillar State: Insights into the Pathogenesis of Parkinson's Disease.Journal of fluorescence, , Volume: 26, Issue:5, 2016
Is age-related failure of metabolic reprogramming a principal mediator in idiopathic Parkinson's disease? Implications for treatment and inverse cancer risk.Medical hypotheses, , Volume: 93, 2016
Formation and Implications of Alpha-Synuclein Radical in Maneb- and Paraquat-Induced Models of Parkinson's Disease.Molecular neurobiology, , Volume: 53, Issue:5, 2016
MAPT haplotype diversity in multiple system atrophy.Parkinsonism & related disorders, , Volume: 30, 2016
Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease.Human molecular genetics, , 08-15, Volume: 25, Issue:16, 2016
The Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation.The Journal of biological chemistry, , 09-02, Volume: 291, Issue:36, 2016
Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation.The Journal of biological chemistry, , 08-26, Volume: 291, Issue:35, 2016
Treatment with Trehalose Prevents Behavioral and Neurochemical Deficits Produced in an AAV α-Synuclein Rat Model of Parkinson's Disease.Molecular neurobiology, , Volume: 53, Issue:4, 2016
The diagnostic discrimination of cutaneous α-synuclein deposition in Parkinson disease.Neurology, , Aug-02, Volume: 87, Issue:5, 2016
Bee venom phospholipase A2 ameliorates motor dysfunction and modulates microglia activation in Parkinson's disease alpha-synuclein transgenic mice.Experimental & molecular medicine, , 07-08, Volume: 48, Issue:7, 2016
Longitudinal live imaging of retinal α-synuclein::GFP deposits in a transgenic mouse model of Parkinson's Disease/Dementia with Lewy Bodies.Scientific reports, , 07-08, Volume: 6, 2016
The heterozygous A53T mutation in the alpha-synuclein gene in a Chinese Han patient with Parkinson disease: case report and literature review.Journal of neurology, , Volume: 263, Issue:10, 2016
[Autophagy pathways and key drug targets in Parkinson's disease].Yao xue xue bao = Acta pharmaceutica Sinica, , Volume: 51, Issue:1, 2016
From the Cover: Arsenic Induces Accumulation of α-Synuclein: Implications for Synucleinopathies and Neurodegeneration.Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 153, Issue:2, 2016
The rs3756063 polymorphism is associated with SNCA methylation in the Chinese Han population.Journal of the neurological sciences, , Aug-15, Volume: 367, 2016
White matter hyperintensities, cerebrospinal amyloid-β and dementia in Parkinson's disease.Journal of the neurological sciences, , Aug-15, Volume: 367, 2016
Pedunculopontine cell loss and protein aggregation direct microglia activation in parkinsonian rats.Brain structure & function, , Volume: 221, Issue:4, 2016
Gut dysfunction in Parkinson's disease.World journal of gastroenterology, , Jul-07, Volume: 22, Issue:25, 2016
Gastrointestinal Dysfunction and Neuropathologic Correlations in Parkinson Disease.Journal of clinical gastroenterology, , Volume: 50, Issue:9, 2016
Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 07-20, Volume: 36, Issue:29, 2016
Mutation analysis of the PARKIN, PINK1, DJ1, and SNCA genes in Turkish early-onset Parkinson's patients and genotype-phenotype correlations.Clinical neurology and neurosurgery, , Volume: 148, 2016
Beta-asarone protects against MPTP-induced Parkinson's disease via regulating long non-coding RNA MALAT1 and inhibiting α-synuclein protein expression.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 83, 2016
From the Cover: Alterations in Optineurin Expression and Localization in Pre-clinical Parkinson's Disease Models.Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 153, Issue:2, 2016
[A Therapeutic Target for Inhibition of Neurodegeneration: Autophagy].Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova, , Volume: 66, Issue:5, 2016
The effect of fluorescent labeling on α-synuclein fibril morphology.Biochimica et biophysica acta, , Volume: 1864, Issue:10, 2016
α-Synuclein: Experimental Pathology.Cold Spring Harbor perspectives in medicine, , Sep-01, Volume: 6, Issue:9, 2016
Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril.Scientific reports, , 08-04, Volume: 6, 2016
Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson's disease.The Journal of experimental medicine, , 08-22, Volume: 213, Issue:9, 2016
Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson's disease.Oncotarget, , Aug-23, Volume: 7, Issue:34, 2016
Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease.PloS one, , Volume: 11, Issue:8, 2016
Copper Binding and Subsequent Aggregation of α-Synuclein Are Modulated by N-Terminal Acetylation and Ablated by the H50Q Missense Mutation.Biochemistry, , 08-30, Volume: 55, Issue:34, 2016
FTY720/Fingolimod Reduces Synucleinopathy and Improves Gut Motility in A53T Mice: CONTRIBUTIONS OF PRO-BRAIN-DERIVED NEUROTROPHIC FACTOR (PRO-BDNF) AND MATURE BDNF.The Journal of biological chemistry, , 09-23, Volume: 291, Issue:39, 2016
SNCA rs356182 variant increases risk of sporadic Parkinson's disease in ethnic Chinese.Journal of the neurological sciences, , Sep-15, Volume: 368, 2016
Self-Assembled Cyclic d,l-α-Peptides as Generic Conformational Inhibitors of the α-Synuclein Aggregation and Toxicity: In Vitro and Mechanistic Studies.Chemistry (Weinheim an der Bergstrasse, Germany), , Sep-26, Volume: 22, Issue:40, 2016
Longitudinal changes in CSF alpha-synuclein species reflect Parkinson's disease progression.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:10, 2016
A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein.Molecular neurodegeneration, , 08-22, Volume: 11, Issue:1, 2016
Caspase-1 clipping causes complications for α-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , Sep-06, Volume: 113, Issue:36, 2016
Cerebrospinal Fluid Biomarkers in Highly Exposed PM2.5 Urbanites: The Risk of Alzheimer's and Parkinson's Diseases in Young Mexico City Residents.Journal of Alzheimer's disease : JAD, , 09-06, Volume: 54, Issue:2, 2016
Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation.Proceedings of the National Academy of Sciences of the United States of America, , 09-13, Volume: 113, Issue:37, 2016
Potential Pathways of Abnormal Tau and α-Synuclein Dissemination in Sporadic Alzheimer's and Parkinson's Diseases.Cold Spring Harbor perspectives in biology, , Nov-01, Volume: 8, Issue:11, 2016
Multicenter Assessment of Immunohistochemical Methods for Pathological Alpha-Synuclein in Sigmoid Colon of Autopsied Parkinson's Disease and Control Subjects.Journal of Parkinson's disease, , 10-19, Volume: 6, Issue:4, 2016
Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation.The Journal of cell biology, , 09-12, Volume: 214, Issue:6, 2016
Can we use peripheral tissue biopsies to diagnose Parkinson's disease? A review of the literature.European journal of neurology, , Volume: 23, Issue:2, 2016
'Under pressure': is there a link between orthostatic hypotension and cognitive impairment in α-synucleinopathies?Journal of neurology, neurosurgery, and psychiatry, , Volume: 87, Issue:12, 2016
Lysosomal trafficking defects link Parkinson's disease with Gaucher's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:11, 2016
Alpha-Synuclein Proteins Promote Pro-Inflammatory Cascades in Microglia: Stronger Effects of the A53T Mutant.PloS one, , Volume: 11, Issue:9, 2016
Total α-synuclein levels in human blood cells, CSF, and saliva determined by a lipid-ELISA.Analytical and bioanalytical chemistry, , Volume: 408, Issue:27, 2016
α-Synuclein is a Novel Microtubule Dynamase.Scientific reports, , 09-15, Volume: 6, 2016
Interactions Between α-Synuclein and Tau Protein: Implications to Neurodegenerative Disorders.Journal of molecular neuroscience : MN, , Volume: 60, Issue:3, 2016
Acteoside Binds to Caspase-3 and Exerts Neuroprotection in the Rotenone Rat Model of Parkinson's Disease.PloS one, , Volume: 11, Issue:9, 2016
α-Synuclein pre-formed fibrils impair tight junction protein expression without affecting cerebral endothelial cell function.Experimental neurology, , Volume: 285, Issue:Pt A, 2016
Chronic mild stress accelerates the progression of Parkinson's disease in A53T α-synuclein transgenic mice.Experimental neurology, , Volume: 285, Issue:Pt A, 2016
Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation.Stem cell reports, , 10-11, Volume: 7, Issue:4, 2016
Perspective: Finding common ground.Nature, , 09-22, Volume: 537, Issue:7621, 2016
An Overview on the Role of α -Synuclein in Experimental Models of Parkinson's Disease from Pathogenesis to Therapeutics.CNS & neurological disorders drug targets, , Volume: 15, Issue:10, 2016
Site-specific structural dynamics of α-Synuclein revealed by time-resolved fluorescence spectroscopy: a review.Methods and applications in fluorescence, , 10-11, Volume: 4, Issue:4, 2016
Novel Dimer Compounds That Bind α-Synuclein Can Rescue Cell Growth in a Yeast Model Overexpressing α-Synuclein. A Possible Prevention Strategy for Parkinson's Disease.ACS chemical neuroscience, , 12-21, Volume: 7, Issue:12, 2016
Investigational α-synuclein aggregation inhibitors: hope for Parkinson's disease.Expert opinion on investigational drugs, , Volume: 25, Issue:11, 2016
A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease.Brain : a journal of neurology, , Volume: 139, Issue:Pt 12, 2016
[Frequency of single nucleotide polymorphisms and alpha-synuclein haplotypes associated with sporadic Parkinson's disease in the Mexican population].Revista de neurologia, , Oct-16, Volume: 63, Issue:8, 2016
Aged Lewis rats exposed to low and moderate doses of rotenone are a good model for studying the process of protein aggregation and its effects upon central nervous system cell physiology.Arquivos de neuro-psiquiatria, , Volume: 74, Issue:9, 2016
Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3.Science (New York, N.Y.), , 09-30, Volume: 353, Issue:6307, 2016
Immune receptor for pathogenic α-synuclein.Science (New York, N.Y.), , 09-30, Volume: 353, Issue:6307, 2016
Parkinson's disease: SNCA-, PARK2-, and LRRK2- targeting microRNAs elevated in cingulate gyrus.Parkinsonism & related disorders, , Volume: 33, 2016
Chemical Compensation of Mitochondrial Phospholipid Depletion in Yeast and Animal Models of Parkinson's Disease.PloS one, , Volume: 11, Issue:10, 2016
Association between common genetic risk variants and depression in Parkinson's disease: A dPD study in Chinese.Parkinsonism & related disorders, , Volume: 33, 2016
Quantitative evaluation of orofacial motor function in mice: The pasta gnawing test, a voluntary and stress-free behavior test.Journal of neuroscience methods, , 12-01, Volume: 274, 2016
Cutaneous malignant melanoma and Parkinson disease: Common pathways?Annals of neurology, , Volume: 80, Issue:6, 2016
CSF Biomarkers and Its Associations with 18F-AV133 Cerebral VMAT2 Binding in Parkinson's Disease-A Preliminary Report.PloS one, , Volume: 11, Issue:10, 2016
Parkinson disease: LAG3 facilitates cell-to-cell spread of α-synuclein pathology.Nature reviews. Neurology, , Volume: 12, Issue:12, 2016
α-Synuclein-Based Animal Models of Parkinson's Disease: Challenges and Opportunities in a New Era.Trends in neurosciences, , Volume: 39, Issue:11, 2016
Autosomal dominant Parkinson's disease: Incidence of mutations in LRRK2, SNCA, VPS35 and GBA genes in Brazil.Neuroscience letters, , Dec-02, Volume: 635, 2016
TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau.eLife, , 10-25, Volume: 5, 2016
Glucocerebrosidase, Parkinson disease, and the "senses and intellect".Annals of neurology, , Volume: 80, Issue:5, 2016
Unfolded protein response is activated in Lewy body dementias.Neuropathology and applied neurobiology, , Volume: 42, Issue:4, 2016
Two hundred steps.Nature, , 10-27, Volume: 538, Issue:7626, 2016
Parkinson's disease: 4 big questions.Nature, , 10-27, Volume: 538, Issue:7626, 2016
Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , 11-01, Volume: 113, Issue:44, 2016
[Circadian Regulation and Its Disorders in Parkinson's Disease Patients. Part 2. Experimental Models, Alpha-Synuclein and Melatonin.]Fiziologiia cheloveka, , Volume: 42, Issue:5, 2016
Mathematical models of α-synuclein transport in axons.Computer methods in biomechanics and biomedical engineering, , Volume: 19, Issue:5, 2016
Naturally Occurring Autoantibodies against Tau Protein Are Reduced in Parkinson's Disease Dementia.PloS one, , Volume: 11, Issue:11, 2016
Inhibition of Atg6 and Pi3K59F autophagy genes in neurons decreases lifespan and locomotor ability in Drosophila melanogaster.Genetics and molecular research : GMR, , Oct-24, Volume: 15, Issue:4, 2016
Parkinson Disease.Mayo Clinic proceedings, , Volume: 91, Issue:11, 2016
DNA damage preceding dopamine neuron degeneration in A53T human α-synuclein transgenic mice.Biochemical and biophysical research communications, , Dec-02, Volume: 481, Issue:1-2, 2016
Genetics of Parkinson's disease.Molecular and cellular probes, , Volume: 30, Issue:6, 2016
Defects in trafficking bridge Parkinson's disease pathology and genetics.Nature, , 11-10, Volume: 539, Issue:7628, 2016
Contribution of cholesterol and oxysterols to the pathophysiology of Parkinson's disease.Free radical biology & medicine, , Volume: 101, 2016
Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice.Annals of neurology, , Volume: 80, Issue:5, 2016
Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons.Journal of neuroinflammation, , 11-18, Volume: 13, Issue:1, 2016
Development and characterization of polo-like kinase 2 loaded nanoparticles-A novel strategy for (serine-129) phosphorylation of alpha-synuclein.International journal of pharmaceutics, , Nov-30, Volume: 514, Issue:1, 2016
Active immunization therapies for Parkinson's disease and multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
New insights into cellular α-synuclein homeostasis in health and disease.Current opinion in neurobiology, , Volume: 36, 2016
A novel therapeutic approach for synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:12, 2016
Nanomechanical properties of distinct fibrillar polymorphs of the protein α-synuclein.Scientific reports, , 11-30, Volume: 6, 2016
Towards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parkinson's Disease: Optimization of AAV1/2 Delivery Parameters to Drive Sustained Expression of Alpha Synuclein and Dopaminergic Degeneration in Macaque.PloS one, , Volume: 11, Issue:11, 2016
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease.Cell, , Dec-01, Volume: 167, Issue:6, 2016
Oligomeric α-synuclein and β-amyloid variants as potential biomarkers for Parkinson's and Alzheimer's diseases.The European journal of neuroscience, , Volume: 43, Issue:1, 2016
Neuropathology of α-synuclein propagation and braak hypothesis.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Inhibition of Prolyl Oligopeptidase Restores Spontaneous Motor Behavior in the α-Synuclein Virus Vector-Based Parkinson's Disease Mouse Model by Decreasing α-Synuclein Oligomeric Species in Mouse Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 12-07, Volume: 36, Issue:49, 2016
Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease.Science translational medicine, , 12-07, Volume: 8, Issue:368, 2016
Skin biopsies in the differential diagnosis of parkinsonism: are we ready for simplified protocols?Brain : a journal of neurology, , Volume: 139, Issue:Pt 1, 2016
Reply: Skin biopsies in the differential diagnosis of parkinsonism: are we ready for simplified protocols?Brain : a journal of neurology, , Volume: 139, Issue:Pt 1, 2016
Brain region-dependent differential expression of alpha-synuclein.The Journal of comparative neurology, , Apr-15, Volume: 524, Issue:6, 2016
The involvement of dityrosine crosslinking in α-synuclein assembly and deposition in Lewy Bodies in Parkinson's disease.Scientific reports, , 12-16, Volume: 6, 2016
Combination therapies: The next logical Step for the treatment of synucleinopathies?Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Alpha-Synuclein Produces Early Behavioral Alterations via Striatal Cholinergic Synaptic Dysfunction by Interacting With GluN2D N-Methyl-D-Aspartate Receptor Subunit.Biological psychiatry, , Mar-01, Volume: 79, Issue:5, 2016
Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.Acta neuropathologica, , Volume: 131, Issue:1, 2016
Biological confounders for the values of cerebrospinal fluid proteins in Parkinson's disease and related disorders.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Formation and Characterization of α-Synuclein Oligomers.Methods in molecular biology (Clifton, N.J.), , Volume: 1345, 2016
Fluorescence Methods for Unraveling Oligomeric Amyloid Intermediates.Methods in molecular biology (Clifton, N.J.), , Volume: 1345, 2016
Cell Models to Study Cell-to-Cell Transmission of α-Synuclein.Methods in molecular biology (Clifton, N.J.), , Volume: 1345, 2016
Inhibition effects of tanshinone on the aggregation of α-synuclein.Food & function, , Volume: 7, Issue:1, 2016
Altered α-synuclein, parkin, and synphilin isoform levels in multiple system atrophy brains.Journal of neurochemistry, , Volume: 136, Issue:1, 2016
Non-Amyloid-β Component of Human α-Synuclein Oligomers Induces Formation of New Aβ Oligomers: Insight into the Mechanisms That Link Parkinson's and Alzheimer's Diseases.ACS chemical neuroscience, , Jan-20, Volume: 7, Issue:1, 2016
Immunotherapeutic Approaches Targeting Amyloid-β, α-Synuclein, and Tau for the Treatment of Neurodegenerative Disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 13, Issue:1, 2016
Modulating the Amyloidogenesis of α-Synuclein.Current neuropharmacology, , Volume: 14, Issue:3, 2016
Analysis of the genetic variability in Parkinson's disease from Southern Spain.Neurobiology of aging, , Volume: 37, 2016
Conformational ensemble of human α-synuclein physiological form predicted by molecular simulations.Physical chemistry chemical physics : PCCP, , Feb-17, Volume: 18, Issue:8, 2016
Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease.Antioxidants & redox signaling, , Mar-01, Volume: 24, Issue:7, 2016
Immunomodulation as a neuroprotective and therapeutic strategy for Parkinson's disease.Current opinion in pharmacology, , Volume: 26, 2016
Age-dependent defects of alpha-synuclein oligomer uptake in microglia and monocytes.Acta neuropathologica, , Volume: 131, Issue:3, 2016
Variants in GBA, SNCA, and MAPT influence Parkinson disease risk, age at onset, and progression.Neurobiology of aging, , Volume: 37, 2016
Skin nerve misfolded α-synuclein in pure autonomic failure and Parkinson disease.Annals of neurology, , Volume: 79, Issue:2, 2016
Membrane lipids as therapeutic targets for Parkinson's disease: a possible link between Lewy pathology and membrane lipids.Expert opinion on therapeutic targets, , Volume: 20, Issue:11, 2016
Current disease modifying approaches to treat Parkinson's disease.Cellular and molecular life sciences : CMLS, , Volume: 73, Issue:7, 2016
Sorting out release, uptake and processing of alpha-synuclein during prion-like spread of pathology.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Value of cerebrospinal fluid α-synuclein species as biomarker in Parkinson's diagnosis and prognosis.Biomarkers in medicine, , Volume: 10, Issue:1, 2016
Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies.Brain : a journal of neurology, , Volume: 139, Issue:Pt 2, 2016
Brain aging and Parkinson's disease: New therapeutic approaches using drug delivery systems.Maturitas, , Volume: 84, 2016
Broad neutralization of calcium-permeable amyloid pore channels with a chimeric Alzheimer/Parkinson peptide targeting brain gangliosides.Biochimica et biophysica acta, , Volume: 1862, Issue:2, 2016
Review: Sporadic Parkinson's disease: development and distribution of α-synuclein pathology.Neuropathology and applied neurobiology, , Volume: 42, Issue:1, 2016
Alpha-synuclein in gastric and colonic mucosa in Parkinson's disease: Limited role as a biomarker.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Nociceptin/Orphanin FQ Inhibits the Survival and Axon Growth of Midbrain Dopaminergic Neurons Through a p38-MAPK Dependent Mechanism.Molecular neurobiology, , Volume: 53, Issue:10, 2016
A new biomarker for Parkinson's disease?Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:1, 2016
Development of Nonviral Vectors Targeting the Brain as a Therapeutic Approach For Parkinson's Disease and Other Brain Disorders.Molecular therapy : the journal of the American Society of Gene Therapy, , Volume: 24, Issue:4, 2016
Interaction of α-synuclein with biomembranes in Parkinson's disease--role of cardiolipin.Progress in lipid research, , Volume: 61, 2016
Development of Passive Immunotherapies for Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Alpha synuclein dimers and oligomers are increased in overexpressing conditions in vitro and in vivo.Molecular and cellular neurosciences, , Volume: 71, 2016
Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization.The Journal of biological chemistry, , Feb-26, Volume: 291, Issue:9, 2016
Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology.Acta neuropathologica, , Volume: 131, Issue:3, 2016
Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model by targeting α-synuclein abnormalities in the substantia nigra.Toxicology letters, , Jan-22, Volume: 243, 2016
The analysis of association between SNCA, HUSEYO and CSMD1 gene variants and Parkinson's disease in Iranian population.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 37, Issue:5, 2016
α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.Human molecular genetics, , Mar-15, Volume: 25, Issue:6, 2016
Synphilin-1 attenuates mutant LRRK2-induced neurodegeneration in Parkinson's disease models.Human molecular genetics, , Feb-15, Volume: 25, Issue:4, 2016
Lewy body pathology involves the olfactory cells in Parkinson's disease and related disorders.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:1, 2016
Therapeutic approaches in Parkinson's disease and related disorders.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Review: The spectrum of clinical features seen with alpha synuclein pathology.Neuropathology and applied neurobiology, , Volume: 42, Issue:1, 2016
Prevalence of Submandibular Gland Synucleinopathy in Parkinson's Disease, Dementia with Lewy Bodies and other Lewy Body Disorders.Journal of Parkinson's disease, , Volume: 6, Issue:1, 2016
Dynamic Changes in Striatal mGluR1 But Not mGluR5 during Pathological Progression of Parkinson's Disease in Human Alpha-Synuclein A53T Transgenic Rats: A Multi-PET Imaging Study.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jan-13, Volume: 36, Issue:2, 2016
Differential interaction between iron and mutant alpha-synuclein causes distinctive Parkinsonian phenotypes in Drosophila.Biochimica et biophysica acta, , Volume: 1862, Issue:4, 2016
Variants in the SNCA gene associate with motor progression while variants in the MAPT gene associate with the severity of Parkinson's disease.Parkinsonism & related disorders, , Volume: 24, 2016
Mesenchymal Stem Cells Inhibit Transmission of α-Synuclein by Modulating Clathrin-Mediated Endocytosis in a Parkinsonian Model.Cell reports, , Feb-02, Volume: 14, Issue:4, 2016
Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains.Journal of visualized experiments : JoVE, , Jan-05, Issue:107, 2016
Parkinson disease in 2015: Evolving basic, pathological and clinical concepts in PD.Nature reviews. Neurology, , Volume: 12, Issue:2, 2016
Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson's disease.Molecular neurodegeneration, , Jan-19, Volume: 11, 2016
Synaptic failure and α-synuclein.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Acupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain.Scientific reports, , Jan-21, Volume: 6, 2016
Editorial overview: Neurobiology of disease.Current opinion in neurobiology, , Volume: 36, 2016
Peripheral Synucleinopathy in Early Parkinson's Disease: Submandibular Gland Needle Biopsy Findings.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Stabilization of α-Synuclein Fibril Clusters Prevents Fragmentation and Reduces Seeding Activity and Toxicity.Biochemistry, , Feb-02, Volume: 55, Issue:4, 2016
Gut Feelings About α-Synuclein in Gastrointestinal Biopsies: Biomarker in the Making?Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
The Contursi Family 20 Years Later: Intrafamilial Phenotypic Variability of the SNCA p.A53T Mutation.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites.Nature communications, , Jan-25, Volume: 7, 2016
Lewy- and Alzheimer-type pathologies in midbrain and cerebellum across the Lewy body disorders spectrum.Neuropathology and applied neurobiology, , Volume: 42, Issue:5, 2016
Autophagy and Alpha-Synuclein: Relevance to Parkinson's Disease and Related Synucleopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
The role of biomarkers and imaging in Parkinson's disease.Expert review of neurotherapeutics, , Volume: 16, Issue:2, 2016
A comparative study of the amount of α-synuclein in ischemic stroke and Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 37, Issue:5, 2016
Direct α-synuclein promoter transactivation by the tumor suppressor p53.Molecular neurodegeneration, , Feb-02, Volume: 11, 2016
Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , Feb-16, Volume: 113, Issue:7, 2016
α-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models.Proceedings of the National Academy of Sciences of the United States of America, , Feb-16, Volume: 113, Issue:7, 2016
Structural remodeling during amyloidogenesis of physiological Nα-acetylated α-synuclein.Biochimica et biophysica acta, , Volume: 1864, Issue:5, 2016
The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease.Journal of neurochemistry, , Volume: 137, Issue:3, 2016
Preface.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:2, 2016
Humoral cross reactivity between α-synuclein and herpes simplex-1 epitope in Parkinson's disease, a triggering role in the disease?Journal of neuroimmunology, , Feb-15, Volume: 291, 2016
Parkinson's disease: acid-glucocerebrosidase activity and alpha-synuclein clearance.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer's and Parkinson's Disease.International journal of molecular sciences, , Feb-06, Volume: 17, Issue:2, 2016
Age at onset and Parkinson disease phenotype.Neurology, , Apr-12, Volume: 86, Issue:15, 2016
Longitudinal Measurements of Cerebrospinal Fluid Biomarkers in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:6, 2016
Microwave fields have little effect on α-synuclein aggregation in a Caenorhabditis elegans model of Parkinson's disease.Bioelectromagnetics, , Volume: 37, Issue:2, 2016
Imaging synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:6, 2016
Schizophrenia as a prodromal symptom in a patient harboring SNCA duplication.Parkinsonism & related disorders, , Volume: 25, 2016
Alpha synuclein and crystallin expression in human lens in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:4, 2016
Alpha-synuclein gene variants may predict neurostimulation outcome.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:4, 2016
The novel adaptive rotating beam test unmasks sensorimotor impairments in a transgenic mouse model of Parkinson's disease.Behavioural brain research, , May-01, Volume: 304, 2016
FBXO7 mutations in Parkinson's disease and multiple system atrophy.Neurobiology of aging, , Volume: 40, 2016
An A-PLAuse to a new assay that unveils previously undetected alpha-synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:3, 2016
ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons.Stem cell reports, , Mar-08, Volume: 6, Issue:3, 2016
microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-24, Volume: 36, Issue:8, 2016
BPOZ-2 Gene Delivery Ameliorates Alpha-Synucleinopathy in A53T Transgenic Mouse Model of Parkinson's Disease.Scientific reports, , Feb-26, Volume: 6, 2016
Effects of different isoforms of apoE on aggregation of the α-synuclein protein implicated in Parkinson's disease.Neuroscience letters, , Apr-08, Volume: 618, 2016
A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins.ACS combinatorial science, , Mar-14, Volume: 18, Issue:3, 2016
Lysosomal Dysfunction and α-Synuclein Aggregation in Parkinson's Disease: Diagnostic Links.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:6, 2016
ɑ-Synuclein strains and the variable pathologies of synucleinopathies.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Targeting α-synuclein: Therapeutic options.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:6, 2016
X-ray Crystallographic Structure of Oligomers Formed by a Toxic β-Hairpin Derived from α-Synuclein: Trimers and Higher-Order Oligomers.Journal of the American Chemical Society, , Apr-06, Volume: 138, Issue:13, 2016
Excessive Iron and α-Synuclein Oligomer in Brain are Relevant to Pure Apathy in Parkinson Disease.Journal of geriatric psychiatry and neurology, , Volume: 29, Issue:4, 2016
Alpha-Synuclein as a Biomarker for Parkinson's Disease.Brain pathology (Zurich, Switzerland), , Volume: 26, Issue:3, 2016
Synaptotagmin XI in Parkinson's disease: New evidence from an association study in Spain and Mexico.Journal of the neurological sciences, , Mar-15, Volume: 362, 2016
Glycation in Parkinson's disease and Alzheimer's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:6, 2016
Innate immunity regulates α-synuclein clearance.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:5, 2016
Up-regulation of SNCA gene expression: implications to synucleinopathies.Neurogenetics, , Volume: 17, Issue:3, 2016
Impact of the α-Synuclein Initial Ensemble Structure on Fibrillation Pathways and Kinetics.The journal of physical chemistry. B, , Mar-31, Volume: 120, Issue:12, 2016
Copper dyshomoeostasis in Parkinson's disease: implications for pathogenesis and indications for novel therapeutics.Clinical science (London, England : 1979), , Volume: 130, Issue:8, 2016
Pathological and clinical aspects of alpha/beta synuclein in Parkinson's disease and related disorders.Expert review of neurotherapeutics, , Volume: 16, Issue:5, 2016
Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector.Journal of visualized experiments : JoVE, , Feb-28, Issue:108, 2016
Subgroup differences in 'brain-type' transferrin and α-synuclein in Parkinson's disease and multiple system atrophy.Journal of biochemistry, , Volume: 160, Issue:2, 2016
The red-hot debate about transmissible Alzheimer's.Nature, , Mar-17, Volume: 531, Issue:7594, 2016
Functionally different α-synuclein inclusions yield insight into Parkinson's disease pathology.Scientific reports, , Mar-17, Volume: 6, 2016
Ca2+ is a key factor in α-synuclein-induced neurotoxicity.Journal of cell science, , 05-01, Volume: 129, Issue:9, 2016
Hippocampal α-synuclein and interneurons in Parkinson's disease: Data from human and mouse models.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:7, 2016
α-Synuclein in Extracellular Vesicles: Functional Implications and Diagnostic Opportunities.Cellular and molecular neurobiology, , Volume: 36, Issue:3, 2016
Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons.Proceedings of the National Academy of Sciences of the United States of America, , Apr-05, Volume: 113, Issue:14, 2016
α-Mangostin Inhibits α-Synuclein-Induced Microglial Neuroinflammation and Neurotoxicity.Cellular and molecular neurobiology, , Volume: 36, Issue:5, 2016
Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?Journal of Parkinson's disease, , Volume: 6, Issue:1, 2016
Alterations in Activity-Dependent Neuroprotective Protein in Sporadic and Experimental Parkinson's Disease.Journal of Parkinson's disease, , Volume: 6, Issue:1, 2016
Extracellular α-synuclein--a possible initiator of inflammation in Parkinson's disease.Die Pharmazie, , Volume: 71, Issue:2, 2016
Abnormal Salivary Total and Oligomeric Alpha-Synuclein in Parkinson's Disease.PloS one, , Volume: 11, Issue:3, 2016
The novel mechanism of rotenone-induced α-synuclein phosphorylation via reduced protein phosphatase 2A activity.The international journal of biochemistry & cell biology, , Volume: 75, 2016
Pathological α-synuclein in gastrointestinal tissues from prodromal Parkinson disease patients.Annals of neurology, , Volume: 79, Issue:6, 2016
Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein.Nature structural & molecular biology, , Volume: 23, Issue:5, 2016
How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease?Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration.PLoS genetics, , Volume: 12, Issue:3, 2016
The role of alpha-synuclein in the development of the dopaminergic neurons in the substantia nigra and ventral tegmental area.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, , Volume: 466, 2016
Motor and Nonmotor Features of Carriers of the p.A53T Alpha-Synuclein Mutation: A Longitudinal Study.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:8, 2016
High expression of α-synuclein in damaged mitochondria with PLA2G6 dysfunction.Acta neuropathologica communications, , Mar-30, Volume: 4, 2016
Oligomeropathies and pathogenesis of Alzheimer and Parkinson's diseases.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:6, 2016
Assessment of α-synuclein in submandibular glands of patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study.The Lancet. Neurology, , Volume: 15, Issue:7, 2016
Cerebrospinal fluid biomarkers and clinical features in leucine-rich repeat kinase 2 (LRRK2) mutation carriers.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:6, 2016
Evaluation of alpha-synuclein immunohistochemical methods for the detection of Lewy-type synucleinopathy in gastrointestinal biopsies.Acta neuropathologica communications, , Apr-04, Volume: 4, 2016
V63 and N65 of overexpressed α-synuclein are involved in mitochondrial dysfunction.Brain research, , 07-01, Volume: 1642, 2016
Atp13a2 expression in the periaqueductal gray is decreased in the Pink1 -/- rat model of Parkinson disease.Neuroscience letters, , 05-16, Volume: 621, 2016
Brain Atrophy of Secondary REM-Sleep Behavior Disorder in Neurodegenerative Disease.Journal of Alzheimer's disease : JAD, , 04-05, Volume: 52, Issue:3, 2016
Cortical phosphorylated α-Synuclein levels correlate with brain wave spectra in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 31, Issue:7, 2016
The Parkinson Disease gene SNCA: Evolutionary and structural insights with pathological implication.Scientific reports, , Apr-15, Volume: 6, 2016
Parkinson disease: Peripheral α-synuclein deposits - prodromal markers for Parkinson disease?Nature reviews. Neurology, , Volume: 12, Issue:5, 2016
Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Cellular models for Parkinson's disease.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
α-synuclein genetic variability: A biomarker for dementia in Parkinson disease.Annals of neurology, , Volume: 79, Issue:6, 2016
Resequencing analysis of five Mendelian genes and the top genes from genome-wide association studies in Parkinson's Disease.Molecular neurodegeneration, , Apr-19, Volume: 11, 2016
Parkinson's disease: Guilt by genetic association.Nature, , May-05, Volume: 533, Issue:7601, 2016
Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression.Nature, , May-05, Volume: 533, Issue:7601, 2016
Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease.Acta neuropathologica communications, , Apr-22, Volume: 4, 2016
Coordination and redox properties of copper interaction with α-synuclein.Journal of inorganic biochemistry, , Volume: 163, 2016
A First Tetraplex Assay for the Simultaneous Quantification of Total α-Synuclein, Tau, β-Amyloid42 and DJ-1 in Human Cerebrospinal Fluid.PloS one, , Volume: 11, Issue:4, 2016
DNA methylation in Parkinson's disease.Journal of neurochemistry, , Volume: 139 Suppl 1, 2016
Thiol Oxidation by Diamide Leads to Dopaminergic Degeneration and Parkinsonism Phenotype in Mice: A Model for Parkinson's Disease.Antioxidants & redox signaling, , 08-10, Volume: 25, Issue:5, 2016
shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity.PLoS genetics, , Volume: 12, Issue:4, 2016
Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson's disease.Human molecular genetics, , 07-01, Volume: 25, Issue:13, 2016
Inhibition of Excessive Oxidative Protein Folding Is Protective in MPP(+) Toxicity-Induced Parkinson's Disease Models.Antioxidants & redox signaling, , 09-10, Volume: 25, Issue:8, 2016
Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain.Proceedings of the National Academy of Sciences of the United States of America, , 06-07, Volume: 113, Issue:23, 2016
The Involvement of His50 during Protein Disulfide Isomerase Binding Is Essential for Inhibiting α-Syn Fibril Formation.Biochemistry, , 05-17, Volume: 55, Issue:19, 2016
Early-onset motor impairment and increased accumulation of phosphorylated α-synuclein in the motor cortex of normal aging mice are ameliorated by coenzyme Q.Experimental gerontology, , Volume: 81, 2016
Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 05-04, Volume: 36, Issue:18, 2016
Increased CSF biomarkers of angiogenesis in Parkinson disease.Neurology, , 05-03, Volume: 86, Issue:18, 2016
Geniposide reduces α-synuclein by blocking microRNA-21/lysosome-associated membrane protein 2A interaction in Parkinson disease models.Brain research, , 08-01, Volume: 1644, 2016
Changes in the sympathetic innervation of the gut in rotenone treated mice as possible early biomarker for Parkinson's disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 26, Issue:3, 2016
Derivation, Characterization, and Neural Differentiation of Integration-Free Induced Pluripotent Stem Cell Lines from Parkinson's Disease Patients Carrying SNCA, LRRK2, PARK2, and GBA Mutations.PloS one, , Volume: 11, Issue:5, 2016
What can trigger the onset of Parkinson's disease - A modeling study based on a compartmental model of α-synuclein transport and aggregation in neurons.Mathematical biosciences, , Volume: 278, 2016
α-Synuclein Fibrils Exhibit Gain of Toxic Function, Promoting Tau Aggregation and Inhibiting Microtubule Assembly.The Journal of biological chemistry, , 07-15, Volume: 291, Issue:29, 2016
[SNCA rs356219 AND rs356165 VARIANTS ARE ASSOCIATED WITH PARKINSON'S DISEASE AND INCREASED ALPHA-SYNUCLEIN GENE EXPRESSION IN THE CD45(+)-BLOOD CELLS].Tsitologiia, , Volume: 58, Issue:2, 2016
Subcortical matter in the α-synucleinopathies spectrum: an MRI pilot study.Journal of neurology, , Volume: 263, Issue:8, 2016
Up-regulation of activating transcription factor 4 induces severe loss of dopamine nigral neurons in a rat model of Parkinson's disease.Neuroscience letters, , 08-03, Volume: 627, 2016
A53T in a parkinsonian family: a clinical update of the SNCA phenotypes.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 123, Issue:11, 2016
Vagal neurocircuitry and its influence on gastric motility.Nature reviews. Gastroenterology & hepatology, , Volume: 13, Issue:7, 2016
Engineering therapeutic protein disaggregases.Molecular biology of the cell, , 05-15, Volume: 27, Issue:10, 2016
How strong is the evidence that Parkinson's disease is a prion disorder?Current opinion in neurology, , Volume: 29, Issue:4, 2016
Mitochondrial DNA in CSF distinguishes LRRK2 from idiopathic Parkinson's disease.Neurobiology of disease, , Volume: 94, 2016
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation.Nature chemical biology, , Volume: 11, Issue:3, 2015
Insights on the interaction of alpha-synuclein and metals in the pathophysiology of Parkinson's disease.Metallomics : integrated biometal science, , Volume: 7, Issue:3, 2015
Alpha-synuclein (SNCA) polymorphisms and susceptibility to Parkinson's disease: a meta-analysis.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, , Volume: 168B, Issue:2, 2015
Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo.The Journal of biological chemistry, , Apr-10, Volume: 290, Issue:15, 2015
Anti-human α-synuclein N-terminal peptide antibody protects against dopaminergic cell death and ameliorates behavioral deficits in an AAV-α-synuclein rat model of Parkinson's disease.PloS one, , Volume: 10, Issue:2, 2015
Single fibril growth kinetics of α-synuclein.Journal of molecular biology, , Mar-27, Volume: 427, Issue:6 Pt B, 2015
FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease.Neurobiology of aging, , Volume: 36, Issue:3, 2015
Parkinson disease with REM sleep behavior disorder: features, α-synuclein, and inflammation.Neurology, , Mar-03, Volume: 84, Issue:9, 2015
Involvement of mortalin/GRP75/mthsp70 in the mitochondrial impairments induced by A53T mutant α-synuclein.Brain research, , Apr-16, Volume: 1604, 2015
Pathological interface between oligomeric alpha-synuclein and tau in synucleinopathies.Biological psychiatry, , Nov-15, Volume: 78, Issue:10, 2015
The relation between α-synuclein and microglia in Parkinson's disease: Recent developments.Neuroscience, , Aug-27, Volume: 302, 2015
Multiple system atrophy: the application of genetics in understanding etiology.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 25, Issue:1, 2015
The endosomal pathway in Parkinson's disease.Molecular and cellular neurosciences, , Volume: 66, Issue:Pt A, 2015
Flies with Parkinson's disease.Experimental neurology, , Volume: 274, Issue:Pt A, 2015
NADH fluorescence lifetime is an endogenous reporter of α-synuclein aggregation in live cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 29, Issue:6, 2015
Evaluation of an α synuclein sensitized dendritic cell based vaccine in a transgenic mouse model of Parkinson disease.Human vaccines & immunotherapeutics, , Volume: 11, Issue:4, 2015
α-Synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in Parkinson's disease.Neurobiology of disease, , Volume: 76, 2015
Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease.Neurobiology of disease, , Volume: 77, 2015
Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain.Brain : a journal of neurology, , Volume: 138, Issue:Pt 6, 2015
Progressive aggregation of alpha-synuclein and selective degeneration of lewy inclusion-bearing neurons in a mouse model of parkinsonism.Cell reports, , Mar-03, Volume: 10, Issue:8, 2015
Invasive procedures in Parkinson's disease: let's be aware we are dealing with prion-like proteins.Journal of the neurological sciences, , Apr-15, Volume: 351, Issue:1-2, 2015
A newly discovered neurotoxin ADTIQ associated with hyperglycemia and Parkinson's disease.Biochemical and biophysical research communications, , Apr-10, Volume: 459, Issue:3, 2015
Attenuation of neuromotor deficits by natural antioxidants of Decalepis hamiltonii in transgenic Drosophila model of Parkinson's disease.Neuroscience, , May-07, Volume: 293, 2015
The N Terminus of α-Synuclein Forms Cu(II)-Bridged Oligomers.Chemistry (Weinheim an der Bergstrasse, Germany), , May-04, Volume: 21, Issue:19, 2015
Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease.Trends in biochemical sciences, , Volume: 40, Issue:4, 2015
Neuropathologically mixed Alzheimer's and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes.Acta neuropathologica, , Volume: 129, Issue:5, 2015
Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.Experimental & molecular medicine, , Mar-13, Volume: 47, 2015
Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis.Journal of the American Chemical Society, , Apr-22, Volume: 137, Issue:15, 2015
VPS35 and EIF4G1 interactions and novel candidate genes for PD: from genes to pathways and back.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:4, 2015
Structural alterations of the intestinal epithelial barrier in Parkinson's disease.Acta neuropathologica communications, , Mar-10, Volume: 3, 2015
Targeting α-synuclein oligomers by protein-fragment complementation for drug discovery in synucleinopathies.Expert opinion on therapeutic targets, , Volume: 19, Issue:5, 2015
Glucocerebrosidase and Parkinson disease: Recent advances.Molecular and cellular neurosciences, , Volume: 66, Issue:Pt A, 2015
Parkinson disease: α-synuclein mutational screening and new clinical insight into the p.E46K mutation.Parkinsonism & related disorders, , Volume: 21, Issue:6, 2015
The diagnostic value of minor salivary gland biopsy in clinically diagnosed patients with Parkinson's disease: comparison with DAT PET scans.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 36, Issue:9, 2015
Decrease in plasma levels of α-synuclein is evident in patients with Parkinson's disease after elimination of heterophilic antibody interference.PloS one, , Volume: 10, Issue:4, 2015
Use of CSF α-synuclein in the differential diagnosis between Alzheimer's disease and other neurodegenerative disorders.International psychogeriatrics, , Volume: 27, Issue:9, 2015
Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury.Acta neuropathologica communications, , Mar-24, Volume: 3, 2015
Role of the unfolded protein response in the pathogenesis of Parkinson's disease.Acta neurobiologiae experimentalis, , Volume: 75, Issue:1, 2015
Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling.The Journal of biological chemistry, , May-29, Volume: 290, Issue:22, 2015
Increased 14-3-3 phosphorylation observed in Parkinson's disease reduces neuroprotective potential of 14-3-3 proteins.Neurobiology of disease, , Volume: 79, 2015
The loss of glucose-regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein (α-syn) toxicity to rat nigral neurons.Neurobiology of aging, , Volume: 36, Issue:6, 2015
Reactivity of copper-α-synuclein peptide complexes relevant to Parkinson's disease.Metallomics : integrated biometal science, , Volume: 7, Issue:7, 2015
Could α-synuclein amyloid-like aggregates trigger a prionic neuronal invasion?BioMed research international, , Volume: 2015, 2015
The prion hypothesis of Parkinson's disease.Current neurology and neuroscience reports, , Volume: 15, Issue:5, 2015
The Interplay between Alpha-Synuclein Clearance and Spreading.Biomolecules, , Apr-14, Volume: 5, Issue:2, 2015
Neuroprotective effects of the cultivated Chondrus crispus in a C. elegans model of Parkinson's disease.Marine drugs, , Apr-14, Volume: 13, Issue:4, 2015
Selective loss of glucocerebrosidase activity in sporadic Parkinson's disease and dementia with Lewy bodies.Molecular neurodegeneration, , Mar-27, Volume: 10, 2015
Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity.Molecular neurodegeneration, , Mar-11, Volume: 10, 2015
α-Synuclein pathology accumulates in sacral spinal visceral sensory pathways.Annals of neurology, , Volume: 78, Issue:1, 2015
Neuroimaging in Parkinson's disease: a future perspective.Neurodegenerative disease management, , Volume: 5, Issue:2, 2015
Parkinson's disease and alpha-synucleinopathies: from arising pathways to therapeutic challenge.Central nervous system agents in medicinal chemistry, , Volume: 15, Issue:2, 2015
The role of ATP13A2 in Parkinson's disease: Clinical phenotypes and molecular mechanisms.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:6, 2015
Oligomers of Parkinson's Disease-Related α-Synuclein Mutants Have Similar Structures but Distinctive Membrane Permeabilization Properties.Biochemistry, , May-26, Volume: 54, Issue:20, 2015
Posttranslational Modifications and Clearing of α-Synuclein Aggregates in Yeast.Biomolecules, , Apr-23, Volume: 5, Issue:2, 2015
Relating gas phase to solution conformations: Lessons from disordered proteins.Proteomics, , Volume: 15, Issue:16, 2015
Hyposmia correlates with SNCA variant and non-motor symptoms in Chinese patients with Parkinson's disease.Parkinsonism & related disorders, , Volume: 21, Issue:6, 2015
Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology.Neurobiology of disease, , Volume: 79, 2015
A new role for α-synuclein in Parkinson's disease: Alteration of ER-mitochondrial communication.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:8, 2015
Role of α-synuclein in cognitive dysfunction: Studies in Drosophila melanogaster.Molecular medicine reports, , Volume: 12, Issue:2, 2015
SNCA Gene, but Not MAPT, Influences Onset Age of Parkinson's Disease in Chinese and Australians.BioMed research international, , Volume: 2015, 2015
Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease.Journal of neuroinflammation, , May-14, Volume: 12, 2015
α-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons.Journal of cell science, , Jul-01, Volume: 128, Issue:13, 2015
Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders.Science signaling, , May-12, Volume: 8, Issue:376, 2015
Amyloid-β and α-synuclein cerebrospinal fluid biomarkers and cognition in early Parkinson's disease.Parkinsonism & related disorders, , Volume: 21, Issue:7, 2015
Biomarkers in Parkinson disease: It's time to combine.Neurology, , Jun-16, Volume: 84, Issue:24, 2015
CSF proteins and resting-state functional connectivity in Parkinson disease.Neurology, , Jun-16, Volume: 84, Issue:24, 2015
Splicing: is there an alternative contribution to Parkinson's disease?Neurogenetics, , Volume: 16, Issue:4, 2015
P2X7 receptor is critical in α-synuclein--mediated microglial NADPH oxidase activation.Neurobiology of aging, , Volume: 36, Issue:7, 2015
Mechanisms of alpha-synuclein action on neurotransmission: cell-autonomous and non-cell autonomous role.Biomolecules, , May-13, Volume: 5, Issue:2, 2015
Role of α- and β-Synucleins in the Axonal Pathology of Parkinson's Disease and Related Synucleinopathies.Biomolecules, , May-19, Volume: 5, Issue:2, 2015
Detection of α-synuclein oligomers in red blood cells as a potential biomarker of Parkinson's disease.Neuroscience letters, , Jul-10, Volume: 599, 2015
Transcriptional regulation of the α-synuclein gene in human brain tissue.Neuroscience letters, , Jul-10, Volume: 599, 2015
ExPLAining early synucleinopathies.Brain : a journal of neurology, , Volume: 138, Issue:Pt 6, 2015
Phosphorylated α-synuclein in skin nerve fibres differentiates Parkinson's disease from multiple system atrophy.Brain : a journal of neurology, , Volume: 138, Issue:Pt 8, 2015
Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth.Scientific reports, , May-28, Volume: 5, 2015
The association between infectious burden and Parkinson's disease: A case-control study.Parkinsonism & related disorders, , Volume: 21, Issue:8, 2015
Alpha-Synuclein Pathology in Sensory Nerve Terminals of the Upper Aerodigestive Tract of Parkinson's Disease Patients.Dysphagia, , Volume: 30, Issue:4, 2015
Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations.The Lancet. Neurology, , Volume: 14, Issue:8, 2015
α-Synuclein Shows High Affinity Interaction with Voltage-dependent Anion Channel, Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease.The Journal of biological chemistry, , Jul-24, Volume: 290, Issue:30, 2015
Interaction between Neuromelanin and Alpha-Synuclein in Parkinson's Disease.Biomolecules, , Jun-05, Volume: 5, Issue:2, 2015
Head injury, α-synuclein Rep1 and Parkinson's disease: a meta-analytic view of gene-environment interaction.European journal of neurology, , Volume: 22, Issue:7, 2015
Neurodegeneration: Aggregates feel the strain.Nature, , Jun-18, Volume: 522, Issue:7556, 2015
α-Synuclein strains cause distinct synucleinopathies after local and systemic administration.Nature, , Jun-18, Volume: 522, Issue:7556, 2015
Total and Proteinase K-Resistant α-Synuclein Levels in Erythrocytes, Determined by their Ability to Bind Phospholipids, Associate with Parkinson's Disease.Scientific reports, , Jun-11, Volume: 5, 2015
Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation.Nature communications, , Jun-16, Volume: 6, 2015
Early-onset parkinsonism caused by alpha-synuclein gene triplication: Clinical and genetic findings in a novel family.Parkinsonism & related disorders, , Volume: 21, Issue:8, 2015
Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration.The Journal of biological chemistry, , Aug-07, Volume: 290, Issue:32, 2015
Medial temporal regional argyrophilic grain as a possible important factor affecting dementia in Parkinson's disease.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 35, Issue:5, 2015
Post-translational modification of α-synuclein in Parkinson's disease.Brain research, , Dec-02, Volume: 1628, Issue:Pt B, 2015
Alpha-synuclein A53T mutation is not frequent on a sample of Brazilian Parkinson's disease patients.Arquivos de neuro-psiquiatria, , Volume: 73, Issue:6, 2015
Tea Polyphenols in Parkinson's Disease.Advances in experimental medicine and biology, , Volume: 863, 2015
Validation of a quantitative cerebrospinal fluid alpha-synuclein assay in a European-wide interlaboratory study.Neurobiology of aging, , Volume: 36, Issue:9, 2015
Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease.Human molecular genetics, , Oct-15, Volume: 24, Issue:R1, 2015
[Subtypes of mild cognitive impairment in Parkinson's disease and factors predicting its becoming dementia].Revista de neurologia, , Jul-01, Volume: 61, Issue:1, 2015
α-Synuclein and Lewy pathology in Parkinson's disease.Current opinion in neurology, , Volume: 28, Issue:4, 2015
α-Synuclein in Parkinson's disease: getting to the core of the matter.The Lancet. Neurology, , Volume: 14, Issue:8, 2015
The phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's disease.Journal of neurochemistry, , Volume: 135, Issue:1, 2015
Multiple sclerosis and Parkinson's disease: the two faces of neurodegeneration. Report of the first Greek case and review of the literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 36, Issue:12, 2015
Targeting α-synuclein as a therapeutic strategy for Parkinson's disease.Expert opinion on therapeutic targets, , Volume: 19, Issue:10, 2015
Common pathophysiology affecting diabetic retinopathy and Parkinson's disease.Medical hypotheses, , Volume: 85, Issue:4, 2015
Parkinson disease: Disease-linked morphometric variants of α-synuclein.Nature reviews. Neurology, , Volume: 11, Issue:8, 2015
Diffusion Kurtosis Imaging Detects Microstructural Alterations in Brain of α-Synuclein Overexpressing Transgenic Mouse Model of Parkinson's Disease: A Pilot Study.Neurotoxicity research, , Volume: 28, Issue:4, 2015
Alpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons.Cell death & disease, , Jul-09, Volume: 6, 2015
Heme Stabilization of α-Synuclein Oligomers during Amyloid Fibril Formation.Biochemistry, , Aug-04, Volume: 54, Issue:30, 2015
Alpha-synuclein immunoreactivity patterns in the enteric nervous system.Neuroscience letters, , Aug-18, Volume: 602, 2015
Cysteine cathepsins are essential in lysosomal degradation of α-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , Jul-28, Volume: 112, Issue:30, 2015
L-dopa increases α-synuclein DNA methylation in Parkinson's disease patients in vivo and in vitro.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:13, 2015
Q&A with Dr. John Woulfe.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:8, 2015
Distinctive distribution of phospho-alpha-synuclein in dermal nerves in multiple system atrophy.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:12, 2015
Colonic bacterial composition in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:10, 2015
Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons.Cell death & disease, , Jul-16, Volume: 6, 2015
Experimental modelling of -synuclein aggregation and spreading in synucleinopathies.Bulletin de l'Academie nationale de medecine, , Volume: 199, Issue:6, 2015
Is Cell Death Primary or Secondary in the Pathophysiology of Idiopathic Parkinson's Disease?Biomolecules, , Jul-16, Volume: 5, Issue:3, 2015
Computational Analysis and Functional Prediction of Ubiquitin Hypothetical Protein: A Possible Target in Parkinson Disease.Central nervous system agents in medicinal chemistry, , Volume: 16, Issue:1, 2015
Serotonergic dysfunction in the A53T alpha-synuclein mouse model of Parkinson's disease.Journal of neurochemistry, , Volume: 135, Issue:3, 2015
SNCA rs3822086 C>T Polymorphism Increases the Susceptibility to Parkinson's Disease in a Chinese Han Population.Genetic testing and molecular biomarkers, , Volume: 19, Issue:9, 2015
Peripheral synuclein tissue markers: a step closer to Parkinson's disease diagnosis.Brain : a journal of neurology, , Volume: 138, Issue:Pt 8, 2015
Genetic Variants of SNCA Are Associated with Susceptibility to Parkinson's Disease but Not Amyotrophic Lateral Sclerosis or Multiple System Atrophy in a Chinese Population.PloS one, , Volume: 10, Issue:7, 2015
Did α-Synuclein and Glucocerebrosidase Coevolve? Implications for Parkinson's Disease.PloS one, , Volume: 10, Issue:7, 2015
LK6/Mnk2a is a new kinase of alpha synuclein phosphorylation mediating neurodegeneration.Scientific reports, , Jul-29, Volume: 5, 2015
Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease.Brain : a journal of neurology, , Volume: 138, Issue:Pt 9, 2015
Seeing Is Believing: Alpha-Synuclein Oligomers in Parkinson's Disease Brain.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:10, 2015
Appendectomy may delay Parkinson's disease Onset.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:10, 2015
Cholesterol - A putative endogenous contributor towards Parkinson's disease.Neurochemistry international, , Volume: 90, 2015
Evidence for early and progressive ultrasonic vocalization and oromotor deficits in a PINK1 gene knockout rat model of Parkinson's disease.Journal of neuroscience research, , Volume: 93, Issue:11, 2015
NEURODEGENERATION. Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein.Science (New York, N.Y.), , Aug-07, Volume: 349, Issue:6248, 2015
[Effect of curcumin on oligomer formation and mitochondrial ATP-sensitive potassium channels induced by overexpression or mutation of α-synuclein].Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, , Volume: 32, Issue:4, 2015
REM sleep behavior disorder and neuropathology in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:10, 2015
Amyloid fibrils are the molecular trigger of inflammation in Parkinson's disease.The Biochemical journal, , Nov-01, Volume: 471, Issue:3, 2015
Toxic Oligomeric Alpha-Synuclein Variants Present in Human Parkinson's Disease Brains Are Differentially Generated in Mammalian Cell Models.Biomolecules, , Jul-22, Volume: 5, Issue:3, 2015
Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/α-synuclein aggregation.Autophagy, , Volume: 11, Issue:10, 2015
Human Hsp70 Disaggregase Reverses Parkinson's-Linked α-Synuclein Amyloid Fibrils.Molecular cell, , Sep-03, Volume: 59, Issue:5, 2015
Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation.Molecular neurodegeneration, , Aug-27, Volume: 10, 2015
Transcriptional mutagenesis by 8-oxodG in α-synuclein aggregation and the pathogenesis of Parkinson's disease.Experimental & molecular medicine, , Aug-28, Volume: 47, 2015
Generation of SNCA Cell Models Using Zinc Finger Nuclease (ZFN) Technology for Efficient High-Throughput Drug Screening.PloS one, , Volume: 10, Issue:8, 2015
Longitudinal Metabolomics Profiling of Parkinson's Disease-Related α-Synuclein A53T Transgenic Mice.PloS one, , Volume: 10, Issue:8, 2015
VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function.Cell reports, , Sep-08, Volume: 12, Issue:10, 2015
Colonic mucosal α-synuclein lacks specificity as a biomarker for Parkinson disease.Neurology, , Sep-01, Volume: 85, Issue:9, 2015
Role for the microtubule-associated protein tau variant p.A152T in risk of α-synucleinopathies.Neurology, , Nov-10, Volume: 85, Issue:19, 2015
Cuminaldehyde as the Major Component of Cuminum cyminum, a Natural Aldehyde with Inhibitory Effect on Alpha-Synuclein Fibrillation and Cytotoxicity.Journal of food science, , Volume: 80, Issue:10, 2015
Structure of the toxic core of α-synuclein from invisible crystals.Nature, , Sep-24, Volume: 525, Issue:7570, 2015
High Throughput Sequencing Identifies MicroRNAs Mediating α-Synuclein Toxicity by Targeting Neuroactive-Ligand Receptor Interaction Pathway in Early Stage of Drosophila Parkinson's Disease Model.PloS one, , Volume: 10, Issue:9, 2015
X-linked Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:2, 2015
Phosphorylated α-synuclein in Parkinson's disease: correlation depends on disease severity.Acta neuropathologica communications, , Jan-31, Volume: 3, 2015
Familial Parkinson disease-associated mutations alter the site-specific microenvironment and dynamics of α-synuclein.The Journal of biological chemistry, , Mar-20, Volume: 290, Issue:12, 2015
Polygenic determinants of Parkinson's disease in a Chinese population.Neurobiology of aging, , Volume: 36, Issue:4, 2015
New roles of glycosaminoglycans in α-synuclein aggregation in a cellular model of Parkinson disease.PloS one, , Volume: 10, Issue:1, 2015
Intracellular screening of a peptide library to derive a potent peptide inhibitor of α-synuclein aggregation.The Journal of biological chemistry, , Mar-20, Volume: 290, Issue:12, 2015
A53T human α-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jan-21, Volume: 35, Issue:3, 2015
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.PloS one, , Volume: 10, Issue:1, 2015
Head injury, potential interaction with genes, and risk for Parkinson's disease.Parkinsonism & related disorders, , Volume: 21, Issue:3, 2015
Dissociation of glucocerebrosidase dimer in solution by its co-factor, saposin C.Biochemical and biophysical research communications, , Feb-20, Volume: 457, Issue:4, 2015
Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors.Neurobiology of aging, , Volume: 36, Issue:3, 2015
Lysosomal-associated membrane protein 2 isoforms are differentially affected in early Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:12, 2015
Unraveling the role of hydrogen peroxide in α-synuclein aggregation using an ultrasensitive nanoplasmonic probe.Analytical chemistry, , Feb-03, Volume: 87, Issue:3, 2015
Colonic mucosal a-synuclein lacks specificity as a biomarker for Parkinson disease.Neurology, , Feb-10, Volume: 84, Issue:6, 2015
Role of α-synuclein in inducing innate and adaptive immunity in Parkinson disease.Journal of Parkinson's disease, , Volume: 5, Issue:1, 2015
Social Cognition Impairments in Mice Overexpressing Alpha-Synuclein Under the Thy1 Promoter, a Model of Pre-manifest Parkinson's Disease.Journal of Parkinson's disease, , Volume: 5, Issue:3, 2015
MS-based methods for biomarkers of Parkinson's disease: what is the future?Bioanalysis, , Volume: 7, Issue:2, 2015
Linking the VPS35 and EIF4G1 pathways in Parkinson's disease.Neuron, , Jan-07, Volume: 85, Issue:1, 2015
Prolyl oligopeptidase enhances α-synuclein dimerization via direct protein-protein interaction.The Journal of biological chemistry, , Feb-20, Volume: 290, Issue:8, 2015
Early Parkinson's disease symptoms in α-synuclein transgenic monkeys.Human molecular genetics, , Apr-15, Volume: 24, Issue:8, 2015
Parkinson's disease correlates with promoter methylation in the α-synuclein gene.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:4, 2015
Inhibition of miR-34b and miR-34c enhances α-synuclein expression in Parkinson's disease.FEBS letters, , Jan-30, Volume: 589, Issue:3, 2015
Cutaneous autonomic denervation in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 122, Issue:8, 2015
Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein.Neuron, , Jan-07, Volume: 85, Issue:1, 2015
GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A.Autophagy, , Volume: 11, Issue:10, 2015
A novel bio-orthogonal cross-linker for improved protein/protein interaction analysis.Analytical chemistry, , Feb-03, Volume: 87, Issue:3, 2015
Drugs That Bind to α-Synuclein: Neuroprotective or Neurotoxic?ACS chemical neuroscience, , Dec-16, Volume: 6, Issue:12, 2015
Graphene oxide interfaces in serum based autoantibody quantification.Analytical chemistry, , Jan-06, Volume: 87, Issue:1, 2015
Biomarkers of Parkinson's disease: present and future.Metabolism: clinical and experimental, , Volume: 64, Issue:3 Suppl 1, 2015
The H50Q mutation induces a 10-fold decrease in the solubility of α-synuclein.The Journal of biological chemistry, , Jan-23, Volume: 290, Issue:4, 2015
Oligomerization and Membrane-binding Properties of Covalent Adducts Formed by the Interaction of α-Synuclein with the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL).The Journal of biological chemistry, , Nov-13, Volume: 290, Issue:46, 2015
The Parkinson's disease-related protein DJ-1 protects dopaminergic neurons in vivo and cultured cells from alpha-synuclein and 6-hydroxydopamine toxicity.Neuro-degenerative diseases, , Volume: 15, Issue:1, 2015
Parkinson's disease, anxious depression and serotonin--zooming in on hippocampal neurogenesis.Journal of neurochemistry, , Volume: 135, Issue:3, 2015
Extracellular ATP induces intracellular alpha-synuclein accumulation via P2X1 receptor-mediated lysosomal dysfunction.Neurobiology of aging, , Volume: 36, Issue:2, 2015
Anti-fibrillation potency of caffeic acid against an antidepressant induced fibrillogenesis of human α-synuclein: Implications for Parkinson's disease.Biochimie, , Volume: 108, 2015
Parkinson's disease as a member of Prion-like disorders.Virus research, , Sep-02, Volume: 207, 2015
Pathogenic mechanisms of neurodegeneration in Parkinson disease.Neurologic clinics, , Volume: 33, Issue:1, 2015
(Poly)phenols protect from α-synuclein toxicity by reducing oxidative stress and promoting autophagy.Human molecular genetics, , Mar-15, Volume: 24, Issue:6, 2015
Structural features of membrane-bound glucocerebrosidase and α-synuclein probed by neutron reflectometry and fluorescence spectroscopy.The Journal of biological chemistry, , Jan-09, Volume: 290, Issue:2, 2015
Acceleration of α-synuclein aggregation by exosomes.The Journal of biological chemistry, , Jan-30, Volume: 290, Issue:5, 2015
α-Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinson's disease.Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 143, Issue:2, 2015
CSF biomarkers and clinical progression of Parkinson disease.Neurology, , Jan-06, Volume: 84, Issue:1, 2015
Successful GPi stimulation in genetic Parkinson's disease caused by mosaicism of alpha-synuclein gene duplication: first description.Journal of neurology, , Volume: 262, Issue:1, 2015
A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy.Molecular neurodegeneration, , Sep-23, Volume: 10, 2015
Neural stem cells in Parkinson's disease: a role for neurogenesis defects in onset and progression.Cellular and molecular life sciences : CMLS, , Volume: 72, Issue:4, 2015
Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce Its Aggregation in Cells.The Journal of biological chemistry, , Nov-13, Volume: 290, Issue:46, 2015
Correlates of cerebrospinal fluid levels of oligomeric- and total-α-synuclein in premotor, motor and dementia stages of Parkinson's disease.Journal of neurology, , Volume: 262, Issue:2, 2015
Cyclosporine A and MnTMPyP Alleviate α-Synuclein Expression and Aggregation in Cypermethrin-Induced Parkinsonism.Molecular neurobiology, , Volume: 52, Issue:3, 2015
Head injury, α-synuclein genetic variability and Parkinson's disease.European journal of neurology, , Volume: 22, Issue:5, 2015
Immunotherapy in Parkinson's Disease: Micromanaging Alpha-Synuclein Aggregation.Journal of Parkinson's disease, , Volume: 5, Issue:3, 2015
Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization.Annals of neurology, , Volume: 77, Issue:1, 2015
Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease.Human molecular genetics, , Mar-01, Volume: 24, Issue:5, 2015
The Synaptic Function of α-Synuclein.Journal of Parkinson's disease, , Volume: 5, Issue:4, 2015
Rab11 modulates α-synuclein-mediated defects in synaptic transmission and behaviour.Human molecular genetics, , Feb-15, Volume: 24, Issue:4, 2015
Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression.Human molecular genetics, , Feb-15, Volume: 24, Issue:4, 2015
The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease.Neuroscience, , Aug-27, Volume: 302, 2015
LC-MS-based urinary metabolite signatures in idiopathic Parkinson's disease.Journal of proteome research, , Jan-02, Volume: 14, Issue:1, 2015
Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap?Experimental gerontology, , Volume: 68, 2015
Deconvoluting the complexity of autophagy and Parkinson's disease for potential therapeutic purpose.Oncotarget, , Dec-01, Volume: 6, Issue:38, 2015
Parkinson's disease and age: The obvious but largely unexplored link.Experimental gerontology, , Volume: 68, 2015
Alpha-synuclein as a pathological link between chronic traumatic brain injury and Parkinson's disease.Journal of cellular physiology, , Volume: 230, Issue:5, 2015
DNA methylation levels of α-synuclein intron 1 in the aging brain.Neurobiology of aging, , Volume: 36, Issue:12, 2015
Apoptosis signal-regulating kinase 1 modulates the phenotype of α-synuclein transgenic mice.Neurobiology of aging, , Volume: 36, Issue:1, 2015
Transgenic rodent models to study alpha-synuclein pathogenesis, with a focus on cognitive deficits.Current topics in behavioral neurosciences, , Volume: 22, 2015
Lysosomal dysfunction in Parkinson's disease.Brain : a journal of neurology, , Volume: 138, Issue:Pt 4, 2015
Reply: Lysosomal dysfunction in Parkinson's disease.Brain : a journal of neurology, , Volume: 138, Issue:Pt 4, 2015
Correlation between decreased CSF α-synuclein and Aβ₁₋₄₂ in Parkinson disease.Neurobiology of aging, , Volume: 36, Issue:1, 2015
Survival in synucleinopathies: A prospective cohort study.Neurology, , Nov-03, Volume: 85, Issue:18, 2015
Cerebrospinal fluid alpha-synuclein as a biomarker for Parkinson's disease diagnosis: a systematic review and meta-analysis.The International journal of neuroscience, , Volume: 125, Issue:9, 2015
Potential of Cellular and Animal Models Based on a Prion-Like Propagation of α-Synuclein for Assessing Antiparkinson Agents.Molecular neurobiology, , Volume: 52, Issue:1, 2015
α-Synuclein Misfolding Versus Aggregation Relevance to Parkinson's Disease: Critical Assessment and Modeling.Molecular neurobiology, , Volume: 51, Issue:3, 2015
In vivo gastric detection of α-synuclein inclusions in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:4, 2015
Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson's Disease-like Dementia.Cell, , Oct-08, Volume: 163, Issue:2, 2015
Genetic analysis of SNCA coding mutation in Chinese Han patients with Parkinson disease.Acta neurologica Belgica, , Volume: 115, Issue:3, 2015
Spreading of α-synuclein in the face of axonal transport deficits in Parkinson's disease: a speculative synthesis.Neurobiology of disease, , Volume: 77, 2015
The brainstem pathologies of Parkinson's disease and dementia with Lewy bodies.Brain pathology (Zurich, Switzerland), , Volume: 25, Issue:2, 2015
Defective autophagy in Parkinson's disease: lessons from genetics.Molecular neurobiology, , Volume: 51, Issue:1, 2015
Brain-gut-microbiota axis in Parkinson's disease.World journal of gastroenterology, , Oct-07, Volume: 21, Issue:37, 2015
Fractalkine Signaling Regulates the Inflammatory Response in an α-Synuclein Model of Parkinson Disease.PloS one, , Volume: 10, Issue:10, 2015
Viral vector-based models of Parkinson's disease.Current topics in behavioral neurosciences, , Volume: 22, 2015
Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection.Pharmacology & therapeutics, , Volume: 156, 2015
O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease.Nature chemistry, , Volume: 7, Issue:11, 2015
Untangling a role for tau in synucleinopathies.Biological psychiatry, , Nov-15, Volume: 78, Issue:10, 2015
Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways.BMC neuroscience, , Oct-23, Volume: 16, 2015
Gastric motor dysfunctions in Parkinson's disease: Current pre-clinical evidence.Parkinsonism & related disorders, , Volume: 21, Issue:12, 2015
Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease.Biomolecules, , Oct-16, Volume: 5, Issue:4, 2015
Bent out of shape: α-Synuclein misfolding and the convergence of pathogenic pathways in Parkinson's disease.FEBS letters, , Dec-21, Volume: 589, Issue:24 Pt A, 2015
[The Role of Iron and Alpha-synuclein Interacting in Parkinson's Disease].Sheng li ke xue jin zhan [Progress in physiology], , Volume: 46, Issue:3, 2015
Colonic mucosal α-synuclein lacks specificity as a biomarker for Parkinson disease.Neurology, , Sep-01, Volume: 85, Issue:9, 2015
Author response.Neurology, , Sep-01, Volume: 85, Issue:9, 2015
Tianma Gouteng Yin, a Traditional Chinese Medicine decoction, exerts neuroprotective effects in animal and cellular models of Parkinson's disease.Scientific reports, , Nov-18, Volume: 5, 2015
Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants.Scientific reports, , Nov-19, Volume: 5, 2015
Parkinson's Protein α-Synuclein Binds Efficiently and with a Novel Conformation to Two Natural Membrane Mimics.PloS one, , Volume: 10, Issue:11, 2015
Optimizing Western Blots for the Detection of Endogenous α-Synuclein in the Enteric Nervous System.Journal of Parkinson's disease, , Volume: 5, Issue:4, 2015
Associations between Cerebrospinal Fluid Biomarkers and Cognition in Early Untreated Parkinson's Disease.Journal of Parkinson's disease, , Volume: 5, Issue:4, 2015
Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells.Cell death & disease, , Nov-26, Volume: 6, 2015
Synchrotron FTIR micro-spectroscopy for structural analysis of Lewy bodies in the brain of Parkinson's disease patients.Scientific reports, , Dec-01, Volume: 5, 2015
Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson's disease.Acta neuropathologica communications, , Dec-01, Volume: 3, 2015
Loss of parkin promotes lipid rafts-dependent endocytosis through accumulating caveolin-1: implications for Parkinson's disease.Molecular neurodegeneration, , Dec-01, Volume: 10, 2015
α-synuclein interacts with SOD1 and promotes its oligomerization.Molecular neurodegeneration, , Dec-08, Volume: 10, 2015
Cyclosporin promotes neurorestoration and cell replacement therapy in pre-clinical models of Parkinson's disease.Acta neuropathologica communications, , Dec-14, Volume: 3, 2015
The Interaction of Alpha-synuclein with Membranes and its Implication in Parkinson's Disease: A Literature Review.Natural product communications, , Volume: 10, Issue:10, 2015
Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson's disease.Journal of neuroinflammation, , Dec-18, Volume: 12, 2015
[Histopathological and immunohistochemical study of spinal cord tissues in neurodegenerative diseases].Zhonghua bing li xue za zhi = Chinese journal of pathology, , Volume: 44, Issue:8, 2015
Parkinson's disease and prion disease: Straining the comparison.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:13, 2015
Lysosomal alterations in peripheral blood mononuclear cells of Parkinson's disease patients.Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:13, 2015
Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation.Nature communications, , Dec-19, Volume: 5, 2014
Toll-like receptor expression in the blood and brain of patients and a mouse model of Parkinson's disease.The international journal of neuropsychopharmacology, , Dec-07, Volume: 18, Issue:6, 2014
Author response.Neurology, , Oct-21, Volume: 83, Issue:17, 2014
Models of α-synuclein aggregation in Parkinson's disease.Acta neuropathologica communications, , Dec-13, Volume: 2, 2014
Differential Co-Expression between α-Synuclein and IFN-γ Signaling Genes across Development and in Parkinson's Disease.PloS one, , Volume: 9, Issue:12, 2014
Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment.Autophagy, , Volume: 10, Issue:12, 2014
Spermidine protects against α-synuclein neurotoxicity.Cell cycle (Georgetown, Tex.), , Volume: 13, Issue:24, 2014
Increased DJ-1 in urine exosome of Korean males with Parkinson's disease.BioMed research international, , Volume: 2014, 2014
Naturally occurring alpha-synuclein autoantibodies in Parkinson's disease: sources of (error) variance in biomarker assays.PloS one, , Volume: 9, Issue:12, 2014
Ida-1, the Caenorhabditis elegans orthologue of mammalian diabetes autoantigen IA-2, potentially acts as a common modulator between Parkinson's disease and Diabetes: role of Daf-2/Daf-16 insulin like signalling pathway.PloS one, , Volume: 9, Issue:12, 2014
iPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson's disease.Cell reports, , Nov-20, Volume: 9, Issue:4, 2014
Neurogranin binds α-synuclein in the human superior temporal cortex and interaction is decreased in Parkinson's disease.Brain research, , Dec-03, Volume: 1591, 2014
α-Synuclein amino terminus regulates mitochondrial membrane permeability.Brain research, , Dec-03, Volume: 1591, 2014
Epigenetic upregulation of alpha-synuclein in the rats exposed to methamphetamine.European journal of pharmacology, , Dec-15, Volume: 745, 2014
Mutations in RAB39B cause X-linked intellectual disability and early-onset Parkinson disease with α-synuclein pathology.American journal of human genetics, , Dec-04, Volume: 95, Issue:6, 2014
Isolating potentiated Hsp104 variants using yeast proteinopathy models.Journal of visualized experiments : JoVE, , Nov-11, Issue:93, 2014
Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.PLoS genetics, , Volume: 10, Issue:11, 2014
Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication.PloS one, , Volume: 9, Issue:11, 2014
A relationship between the transient structure in the monomeric state and the aggregation propensities of α-synuclein and β-synuclein.Biochemistry, , Nov-25, Volume: 53, Issue:46, 2014
Early and persistent expression of phosphorylated α-synuclein in the enteric nervous system of A53T mutant human α-synuclein transgenic mice.Journal of neuropathology and experimental neurology, , Volume: 73, Issue:12, 2014
In vivo markers of Parkinson's disease and dementia with Lewy bodies: current value of the 5G4 α-synuclein antibody.Acta neuropathologica, , Volume: 128, Issue:6, 2014
Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation.Brain : a journal of neurology, , Volume: 137, Issue:Pt 12, 2014
Skin nerve α-synuclein deposits: a biomarker for idiopathic Parkinson disease.Neurology, , Oct-21, Volume: 83, Issue:17, 2014
α-Synuclein-induced mitochondrial dysfunction in isolated preparation and intact cells: implications in the pathogenesis of Parkinson's disease.Journal of neurochemistry, , Volume: 131, Issue:6, 2014
The key role of sphingosine kinases in the molecular mechanism of neuronal cell survival and death in an experimental model of Parkinson's disease.Folia neuropathologica, , Volume: 52, Issue:3, 2014
Subthalamic deep brain stimulation for a Parkinson's disease patient with duplication of SNCA.Neuromodulation : journal of the International Neuromodulation Society, , Volume: 17, Issue:1, 2014
Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes.Molecular biology of the cell, , Dec-15, Volume: 25, Issue:25, 2014
Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.Acta neuropathologica, , Volume: 128, Issue:6, 2014
Alpha synuclein is transported into and out of the brain by the blood-brain barrier.Peptides, , Volume: 62, 2014
The newly discovered Parkinson's disease associated Finnish mutation (A53E) attenuates α-synuclein aggregation and membrane binding.Biochemistry, , Oct-21, Volume: 53, Issue:41, 2014
Reduced alpha-synuclein in cerebrospinal fluid in synucleinopathies: evidence from a meta-analysis.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:13, 2014
Ignored avenues in alpha-synuclein associated proteopathy.CNS & neurological disorders drug targets, , Volume: 13, Issue:7, 2014
High stability and cooperative unfolding of α-synuclein oligomers.Biochemistry, , Oct-07, Volume: 53, Issue:39, 2014
[Pathogenetic mechanisms of dementia in the older patients with Parkinson's diseases].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, , Volume: 114, Issue:7, 2014
Phosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson disease.Proceedings of the National Academy of Sciences of the United States of America, , Sep-23, Volume: 111, Issue:38, 2014
Hippocampal proliferation is increased in presymptomatic Parkinson's disease and due to microglia.Neural plasticity, , Volume: 2014, 2014
APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease.JAMA neurology, , Volume: 71, Issue:11, 2014
Effects of the adenosine A2A receptor antagonist on cognitive dysfunction in Parkinson's disease.International review of neurobiology, , Volume: 119, 2014
Using viral-mediated gene delivery to model Parkinson's disease: do nonhuman primate investigations expand our understanding?Experimental neurology, , Volume: 256, 2014
Systems-based analyses of brain regions functionally impacted in Parkinson's disease reveals underlying causal mechanisms.PloS one, , Volume: 9, Issue:8, 2014
Effect of endogenous Hsp104 chaperone in yeast models of sporadic and familial Parkinson's disease.The international journal of biochemistry & cell biology, , Volume: 55, 2014
Glucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein.Nature communications, , Aug-26, Volume: 5, 2014
Structural insights into amyloid oligomers of the Parkinson disease-related protein α-synuclein.The Journal of biological chemistry, , Sep-26, Volume: 289, Issue:39, 2014
Lardy brains make Parkinson's disease mice worse.Journal of neurochemistry, , Volume: 131, Issue:6, 2014
Oligomers of α-synuclein: picking the culprit in the line-up.Essays in biochemistry, , Volume: 56, 2014
Role of α-synuclein in neurodegeneration: implications for the pathogenesis of Parkinson's disease.Essays in biochemistry, , Volume: 56, 2014
Is elevated beta-hexosaminidase activity a potential biomarker for Parkinson's disease?Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:10, 2014
A new Drosophila model to study the interaction between genetic and environmental factors in Parkinson's disease.Brain research, , Oct-02, Volume: 1583, 2014
SNCA variants rs2736990 and rs356220 as risk factors for Parkinson's disease but not for amyotrophic lateral sclerosis and multiple system atrophy in a Chinese population.Neurobiology of aging, , Volume: 35, Issue:12, 2014
GRP78 clustering at the cell surface of neurons transduces the action of exogenous alpha-synuclein.Cell death and differentiation, , Volume: 21, Issue:12, 2014
Pharmacological chaperones in the age of proteomic pathology.Proceedings of the National Academy of Sciences of the United States of America, , Aug-26, Volume: 111, Issue:34, 2014
Calcineurin determines toxic versus beneficial responses to α-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , Aug-26, Volume: 111, Issue:34, 2014
Walking deficits and centrophobism in an α-synuclein fly model of Parkinson's disease.Genes, brain, and behavior, , Volume: 13, Issue:8, 2014
α-Synuclein rs356219 polymorphisms in patients with Gaucher disease and Parkinson disease.Neuroscience letters, , Sep-19, Volume: 580, 2014
Adult hippocampal neurogenesis in Parkinson's disease: impact on neuronal survival and plasticity.Neural plasticity, , Volume: 2014, 2014
VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease.Neurobiology of disease, , Volume: 71, 2014
The paths to neurodegeneration in genetic Parkinson's disease.CNS & neurological disorders drug targets, , Volume: 13, Issue:9, 2014
Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson's disease patients.Acta neuropathologica communications, , Aug-07, Volume: 2, 2014
Late stages of hematopoiesis and B cell lymphopoiesis are regulated by α-synuclein, a key player in Parkinson's disease.Immunobiology, , Volume: 219, Issue:11, 2014
Molecular imaging insights into neurodegeneration: focus on α-synuclein radiotracers.Journal of nuclear medicine : official publication, Society of Nuclear Medicine, , Volume: 55, Issue:9, 2014
The use of nanopore analysis for discovering drugs which bind to α-synuclein for treatment of Parkinson's disease.European journal of medicinal chemistry, , Dec-17, Volume: 88, 2014
Is there a risk of prion-like disease transmission by Alzheimer- or Parkinson-associated protein particles?Acta neuropathologica, , Volume: 128, Issue:4, 2014
DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease.Cell death & disease, , Jul-24, Volume: 5, 2014
miR-16-1 promotes the aberrant α-synuclein accumulation in parkinson disease via targeting heat shock protein 70.TheScientificWorldJournal, , Volume: 2014, 2014
Quantitative measurement of intact alpha-synuclein proteoforms from post-mortem control and Parkinson's disease brain tissue by intact protein mass spectrometry.Scientific reports, , Jul-23, Volume: 4, 2014
A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons.Human molecular genetics, , Dec-15, Volume: 23, Issue:24, 2014
Peripheral alpha-synuclein and Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:8, 2014
Analysis of dopaminergic neuronal dysfunction in genetic and toxin-induced models of Parkinson's disease in Drosophila.Journal of neurochemistry, , Volume: 131, Issue:3, 2014
A GCase chaperone improves motor function in a mouse model of synucleinopathy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 11, Issue:4, 2014
Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice.Neurobiology of aging, , Volume: 35, Issue:11, 2014
Tetranectin knockout mice develop features of Parkinson disease.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , Volume: 34, Issue:2, 2014
Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson disease-associated α-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , Jul-29, Volume: 111, Issue:30, 2014
Parkinson disease: A monoclonal antibody targeting misfolded α-synuclein has therapeutic potential in Parkinson disease.Nature reviews. Neurology, , Volume: 10, Issue:8, 2014
Reduced α-synuclein levels in cerebrospinal fluid in Parkinson's disease are unrelated to clinical and imaging measures of disease severity.European journal of neurology, , Volume: 21, Issue:3, 2014
Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson's disease.Acta neuropathologica, , Volume: 128, Issue:5, 2014
Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:10, 2014
Diet-induced obesity accelerates the onset of terminal phenotypes in α-synuclein transgenic mice.Journal of neurochemistry, , Volume: 131, Issue:6, 2014
Cell-based assays for Parkinson's disease using differentiated human LUHMES cells.Acta pharmacologica Sinica, , Volume: 35, Issue:7, 2014
Divergent effects of the H50Q and G51D SNCA mutations on the aggregation of α-synuclein.Journal of neurochemistry, , Volume: 131, Issue:6, 2014
[The role of alpha-synuclein in Parkinson's disease].Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, , Volume: 16, Issue:2, 2014
[The role of parkin in Parkinson's disease].Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, , Volume: 16, Issue:2, 2014
Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies.Human molecular genetics, , Dec-01, Volume: 23, Issue:23, 2014
Catecholamine autotoxicity. Implications for pharmacology and therapeutics of Parkinson disease and related disorders.Pharmacology & therapeutics, , Volume: 144, Issue:3, 2014
The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity.The Journal of biological chemistry, , Aug-08, Volume: 289, Issue:32, 2014
Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration.Cell reports, , Jun-26, Volume: 7, Issue:6, 2014
Microarray-based analyses of monocytes from Chinese Uygur patients with Parkinson's disease and cognitive impairment.Chinese medical journal, , Volume: 127, Issue:12, 2014
Reply to: alimentary, my dear Watson? The challenges of enteric α-synuclein as a Parkinson's disease biomarker.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:9, 2014
Reply to: Gray et al.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:9, 2014
Glucocerebrosidase deficits in sporadic Parkinson disease.Autophagy, , Volume: 10, Issue:7, 2014
LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis.Experimental neurology, , Volume: 261, 2014
Lysine residues at the first and second KTKEGV repeats mediate α-Synuclein binding to membrane phospholipids.Neurobiology of disease, , Volume: 70, 2014
Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:8, 2014
Multiple system atrophy as emerging template for accelerated drug discovery in α-synucleinopathies.Parkinsonism & related disorders, , Volume: 20, Issue:8, 2014
The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models.Cell metabolism, , Jul-01, Volume: 20, Issue:1, 2014
Olfactory deficits in an alpha-synuclein fly model of Parkinson's disease.PloS one, , Volume: 9, Issue:5, 2014
Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread.Neurobiology of disease, , Volume: 69, 2014
Sleep dysfunction and EEG alterations in mice overexpressing alpha-synuclein.Journal of Parkinson's disease, , Volume: 4, Issue:3, 2014
The prion hypothesis of Parkinson's disease: this hot topic just got hotter.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:8, 2014
Histone deacetylase 6 regulates cytotoxic α-synuclein accumulation through induction of the heat shock response.Neurobiology of aging, , Volume: 35, Issue:10, 2014
Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation.The Journal of clinical investigation, , Volume: 124, Issue:7, 2014
Beta-amyloid, phospho-tau and alpha-synuclein deposits similar to those in the brain are not identified in the eyes of Alzheimer's and Parkinson's disease patients.Brain pathology (Zurich, Switzerland), , Volume: 24, Issue:1, 2014
The PD-associated alpha-synuclein promoter Rep1 allele 2 shows diminished frequency in restless legs syndrome.Neurogenetics, , Volume: 15, Issue:3, 2014
Guanidine hydrochloride denaturation of dopamine-induced α-synuclein oligomers: a small-angle X-ray scattering study.Proteins, , Volume: 82, Issue:1, 2014
Prions: generation and spread versus neurotoxicity.The Journal of biological chemistry, , Jul-18, Volume: 289, Issue:29, 2014
Accurate prediction of a minimal region around a genetic association signal that contains the causal variant.European journal of human genetics : EJHG, , Volume: 22, Issue:2, 2014
Mouse models for studying the formation and propagation of prions.The Journal of biological chemistry, , Jul-18, Volume: 289, Issue:29, 2014
Differential protein profile of PC12 cells exposed to proteasomal inhibitor lactacystin.Neuroscience letters, , Jul-11, Volume: 575, 2014
Modulatory effects of sodium salicylate on the factors affecting protein aggregation during rotenone induced Parkinson's disease pathology.Neurochemistry international, , Volume: 75, 2014
Monoamine oxidase and α-synuclein as targets in Parkinson's disease therapy.Expert review of neurotherapeutics, , Volume: 14, Issue:6, 2014
Overexpression of human E46K mutant α-synuclein impairs macroautophagy via inactivation of JNK1-Bcl-2 pathway.Molecular neurobiology, , Volume: 50, Issue:2, 2014
Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.The Journal of biological chemistry, , Jun-27, Volume: 289, Issue:26, 2014
Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental Parkinson's disease.Neurobiology of disease, , Volume: 69, 2014
Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation.Proceedings of the National Academy of Sciences of the United States of America, , May-27, Volume: 111, Issue:21, 2014
α-synuclein in the inner retina in parkinson disease.Annals of neurology, , Volume: 75, Issue:6, 2014
Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's disease.PLoS genetics, , Volume: 10, Issue:5, 2014
Self-assembly of protein fibrils into suprafibrillar aggregates: bridging the nano- and mesoscale.ACS nano, , Jun-24, Volume: 8, Issue:6, 2014
[Alpha-Synuclein in blood and cerebrospinal fluid of patients with alpha-synucleinopathy].Rinsho byori. The Japanese journal of clinical pathology, , Volume: 62, Issue:3, 2014
Cutaneous neuropathy in Parkinson's disease: a window into brain pathology.Acta neuropathologica, , Volume: 128, Issue:1, 2014
Phosphorylated α-synuclein-immunoreactive retinal neuronal elements in Parkinson's disease subjects.Neuroscience letters, , Jun-13, Volume: 571, 2014
Calcium signaling in Parkinson's disease.Cell and tissue research, , Volume: 357, Issue:2, 2014
Vocalization deficits in mice over-expressing alpha-synuclein, a model of pre-manifest Parkinson's disease.Behavioral neuroscience, , Volume: 128, Issue:2, 2014
Magic shotgun for Parkinson's disease?Brain : a journal of neurology, , Volume: 137, Issue:Pt 5, 2014
Genetic variants and animal models in SNCA and Parkinson disease.Ageing research reviews, , Volume: 15, 2014
Analysis of Parkinson's disease brain-derived DNA for alpha-synuclein coding somatic mutations.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:8, 2014
Novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology.Neurobiology of aging, , Volume: 35, Issue:9, 2014
Residue histidine 50 plays a key role in protecting α-synuclein from aggregation at physiological pH.The Journal of biological chemistry, , May-30, Volume: 289, Issue:22, 2014
Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson's disease.Neurobiology of aging, , Volume: 35, Issue:10, 2014
A revised picture of the Cu(II)-α-synuclein complex: the role of N-terminal acetylation.Biochemistry, , May-06, Volume: 53, Issue:17, 2014
MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration.Nature communications, , Apr-16, Volume: 5, 2014
The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells.Human molecular genetics, , Sep-01, Volume: 23, Issue:17, 2014
Roche bets on alpha-synuclein for Parkinson's.Nature biotechnology, , Volume: 32, Issue:3, 2014
Multiple system atrophy: a prototypical synucleinopathy for disease-modifying therapeutic strategies.Neurobiology of disease, , Volume: 67, 2014
Site-specific copper-catalyzed oxidation of α-synuclein: tightening the link between metal binding and protein oxidative damage in Parkinson's disease.Inorganic chemistry, , May-05, Volume: 53, Issue:9, 2014
Pyrosequencing analysis of SNCA methylation levels in leukocytes from Parkinson's disease patients.Neuroscience letters, , May-21, Volume: 569, 2014
[Alpha-synuclein in Parkinson's disease].Przeglad lekarski, , Volume: 71, Issue:1, 2014
Alpha-synuclein in peripheral tissues and body fluids as a biomarker for Parkinson's disease - a systematic review.Acta neurologica Scandinavica, , Volume: 130, Issue:2, 2014
Association of glycogen synthase kinase-3β with Parkinson's disease (review).Molecular medicine reports, , Volume: 9, Issue:6, 2014
Vaccination strategies for Parkinson disease: induction of a swift attack or raising tolerance?Human vaccines & immunotherapeutics, , Volume: 10, Issue:4, 2014
Effect of epicatechin gallate dietary supplementation on transgenic Drosophila model of Parkinson's disease.Journal of dietary supplements, , Volume: 11, Issue:2, 2014
Development of targeted therapies for Parkinson's disease and related synucleinopathies.Journal of lipid research, , Volume: 55, Issue:10, 2014
Direct visualization of CHIP-mediated degradation of alpha-synuclein in vivo: implications for PD therapeutics.PloS one, , Volume: 9, Issue:3, 2014
Does α-synuclein have a dual and opposing effect in preclinical vs. clinical Parkinson's disease?Parkinsonism & related disorders, , Volume: 20, Issue:6, 2014
Skin nerve α-synuclein deposits: a biomarker for idiopathic Parkinson disease.Neurology, , Apr-15, Volume: 82, Issue:15, 2014
Phospholipase D1 regulates autophagic flux and clearance of α-synuclein aggregates.Cell death and differentiation, , Volume: 21, Issue:7, 2014
RNA metabolism in the pathogenesis of Parkinson׳s disease.Brain research, , Oct-10, Volume: 1584, 2014
Neuroprotective effects of mesenchymal stem cells through autophagy modulation in a parkinsonian model.Neurobiology of aging, , Volume: 35, Issue:8, 2014
Differential aggregation properties of alpha-synuclein isoforms.Neurobiology of aging, , Volume: 35, Issue:8, 2014
Cerebrospinal fluid α-synuclein predicts cognitive decline in Parkinson disease progression in the DATATOP cohort.The American journal of pathology, , Volume: 184, Issue:4, 2014
Sequestration of a β-hairpin for control of α-synuclein aggregation.Angewandte Chemie (International ed. in English), , Apr-14, Volume: 53, Issue:16, 2014
Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice.Human molecular genetics, , Aug-01, Volume: 23, Issue:15, 2014
A generic method for design of oligomer-specific antibodies.PloS one, , Volume: 9, Issue:3, 2014
Do prions cause Parkinson disease?: the evidence accumulates.Annals of neurology, , Volume: 75, Issue:3, 2014
Protein folding and misfolding in the neurodegenerative disorders: a review.Revue neurologique, , Volume: 170, Issue:3, 2014
Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes.Human molecular genetics, , Jun-01, Volume: 23, Issue:11, 2014
Complex deregulation and expression of cytokines and mediators of the immune response in Parkinson's disease brain is region dependent.Brain pathology (Zurich, Switzerland), , Volume: 24, Issue:6, 2014
Using gastrocnemius sEMG and plasma α-synuclein for the prediction of freezing of gait in Parkinson's disease patients.PloS one, , Volume: 9, Issue:2, 2014
Zonisamide attenuates α-synuclein neurotoxicity by an aggregation-independent mechanism in a rat model of familial Parkinson's disease.PloS one, , Volume: 9, Issue:2, 2014
Comparable autoantibody serum levels against amyloid- and inflammation-associated proteins in Parkinson's disease patients and controls.PloS one, , Volume: 9, Issue:2, 2014
Alpha-synuclein repeat variants and survival in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:8, 2014
Molecular basis for preventing α-synuclein aggregation by a molecular tweezer.The Journal of biological chemistry, , Apr-11, Volume: 289, Issue:15, 2014
Trifluoperazine rescues human dopaminergic cells from wild-type α-synuclein-induced toxicity.Neurobiology of aging, , Volume: 35, Issue:7, 2014
Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease.PloS one, , Volume: 9, Issue:2, 2014
Glucocerebrosidase is shaking up the synucleinopathies.Brain : a journal of neurology, , Volume: 137, Issue:Pt 5, 2014
The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation.Journal of the American Chemical Society, , Mar-12, Volume: 136, Issue:10, 2014
Next-generation active immunization approach for synucleinopathies: implications for Parkinson's disease clinical trials.Acta neuropathologica, , Volume: 127, Issue:6, 2014
A 'bird's eye' view on the current status and potential benefits of blood biomarkers for Parkinson's disease.Biomarkers in medicine, , Volume: 8, Issue:2, 2014
Identification of a novel Parkinson's disease locus via stratified genome-wide association study.BMC genomics, , Feb-10, Volume: 15, 2014
CSF α-synuclein and UCH-L1 levels in Parkinson's disease and atypical parkinsonian disorders.Parkinsonism & related disorders, , Volume: 20, Issue:4, 2014
[Proteomic biomarkers in Parkinson's disease].Revista de neurologia, , Feb-16, Volume: 58, Issue:4, 2014
Presynaptic alpha-synuclein aggregation in a mouse model of Parkinson's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-05, Volume: 34, Issue:6, 2014
Submandibular gland needle biopsy for the diagnosis of Parkinson disease.Neurology, , Mar-11, Volume: 82, Issue:10, 2014
Comment: Braak staging in clinical practice?Neurology, , Mar-11, Volume: 82, Issue:10, 2014
Intra-axonal protein aggregation in the peripheral nervous system.Journal of the peripheral nervous system : JPNS, , Volume: 19, Issue:1, 2014
Immunotherapy targeting α-synuclein, with relevance for future treatment of Parkinson's disease and other Lewy body disorders.Immunotherapy, , Volume: 6, Issue:2, 2014
A30P α-Synuclein interferes with the stable integration of adult-born neurons into the olfactory network.Scientific reports, , Feb-03, Volume: 4, 2014
Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease.Brain : a journal of neurology, , Volume: 137, Issue:Pt 3, 2014
Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels.PloS one, , Volume: 9, Issue:1, 2014
Evidence of native α-synuclein conformers in the human brain.The Journal of biological chemistry, , Mar-14, Volume: 289, Issue:11, 2014
The pathomechanisms underlying Parkinson's disease.Expert review of neurotherapeutics, , Volume: 14, Issue:2, 2014
Chronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not α-synuclein-induced neuronal cell loss.PloS one, , Volume: 9, Issue:1, 2014
Genetics of Parkinson's disease: alpha-synuclein and other insights from Greece.European journal of neurology, , Volume: 21, Issue:7, 2014
The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans.Metallomics : integrated biometal science, , Volume: 6, Issue:3, 2014
Site-specific fluorescence dynamics of α-synuclein fibrils using time-resolved fluorescence studies: effect of familial Parkinson's disease-associated mutations.Biochemistry, , Feb-11, Volume: 53, Issue:5, 2014
Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events.Cell, , Jan-16, Volume: 156, Issue:1-2, 2014
Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:8, 2014
Predictive association of copper metabolism proteins with Alzheimer's disease and Parkinson's disease: a preliminary perspective.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, , Volume: 27, Issue:1, 2014
Interactions between Tau and α-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease.Human molecular genetics, , Jun-01, Volume: 23, Issue:11, 2014
n-butylidenephthalide protects against dopaminergic neuron degeneration and α-synuclein accumulation in Caenorhabditis elegans models of Parkinson's disease.PloS one, , Volume: 9, Issue:1, 2014
c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease.Human molecular genetics, , Jun-01, Volume: 23, Issue:11, 2014
Methylation of α-synuclein and leucine-rich repeat kinase 2 in leukocyte DNA of Parkinson's disease patients.Parkinsonism & related disorders, , Volume: 20, Issue:3, 2014
Reaping what you sow: Cross-seeding between aggregation-prone proteins in neurodegeneration.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:3, 2014
Neuroinflammation and α-synuclein accumulation in response to glucocerebrosidase deficiency are accompanied by synaptic dysfunction.Molecular genetics and metabolism, , Volume: 111, Issue:2, 2014
Squamosamide derivative FLZ protected dopaminergic neuron by activating Akt signaling pathway in 6-OHDA-induced in vivo and in vitro Parkinson's disease models.Brain research, , Feb-14, Volume: 1547, 2014
Modeling Parkinson's disease in a dish--a story of yeast and men.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:1, 2014
Alimentary, my dear Watson? The challenges of enteric α-synuclein as a Parkinson's disease biomarker.Movement disorders : official journal of the Movement Disorder Society, , Volume: 29, Issue:4, 2014
The N-terminus of α-synuclein is essential for both monomeric and oligomeric interactions with membranes.FEBS letters, , Jan-31, Volume: 588, Issue:3, 2014
Electrochemical analysis of the fibrillation of Parkinson's disease α-synuclein.The Analyst, , Feb-21, Volume: 139, Issue:4, 2014
Neurodegenerative disease: Yeast cells reveal new target for Parkinson's disease.Nature reviews. Drug discovery, , Volume: 13, Issue:1, 2014
Protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants.Neurobiology of aging, , Volume: 35, Issue:1, 2014
Cerebrospinal fluid α-synuclein levels in Parkinson's disease--changed or unchanged?European journal of neurology, , Volume: 21, Issue:3, 2014
Hypomethylation of SNCA in blood of patients with sporadic Parkinson's disease.Journal of the neurological sciences, , Feb-15, Volume: 337, Issue:1-2, 2014
Mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice.Neurobiology of aging, , Volume: 35, Issue:5, 2014
Clinical and neuroimaging features of patient with early-onset Parkinson's disease with dementia carrying SNCA p.G51D mutation.Parkinsonism & related disorders, , Volume: 20, Issue:2, 2014
Genetic assessment of familial and early-onset Parkinson's disease in a Greek population.European journal of neurology, , Volume: 21, Issue:7, 2014
Heat shock protein 70 reduces α-synuclein-induced predegenerative neuronal dystrophy in the α-synuclein viral gene transfer rat model of Parkinson's disease.CNS neuroscience & therapeutics, , Volume: 20, Issue:1, 2014
Characterization of polyethylene glycol-polyethyleneimine as a vector for alpha-synuclein siRNA delivery to PC12 cells for Parkinson's disease.CNS neuroscience & therapeutics, , Volume: 20, Issue:1, 2014
5-S-cysteinyldopamine neurotoxicity: Influence on the expression of α-synuclein and ERp57 in cellular and animal models of Parkinson's disease.Journal of neuroscience research, , Volume: 92, Issue:3, 2014
A quantitative study of α-synuclein pathology in fifteen cases of dementia associated with Parkinson disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 121, Issue:2, 2014
Modeling Lewy pathology propagation in Parkinson's disease.Parkinsonism & related disorders, , Volume: 20 Suppl 1, 2014
Quantification of α-synuclein in cerebrospinal fluid: how ideal is this biomarker for Parkinson's disease?Parkinsonism & related disorders, , Volume: 20 Suppl 1, 2014
α-Synucleinopathy phenotypes.Parkinsonism & related disorders, , Volume: 20 Suppl 1, 2014
Staged pathology in Parkinson's disease.Parkinsonism & related disorders, , Volume: 20 Suppl 1, 2014
Update on novel familial forms of Parkinson's disease and multiple system atrophy.Parkinsonism & related disorders, , Volume: 20 Suppl 1, 2014
Genetic causes of Parkinson's disease and their links to autophagy regulation.Parkinsonism & related disorders, , Volume: 20 Suppl 1, 2014
The significance of α-synuclein, amyloid-β and tau pathologies in Parkinson's disease progression and related dementia.Neuro-degenerative diseases, , Volume: 13, Issue:2-3, 2014
Increased amoeboid microglial density in the olfactory bulb of Parkinson's and Alzheimer's patients.Brain pathology (Zurich, Switzerland), , Volume: 24, Issue:2, 2014
Parkinson's disease in a dish - Using stem cells as a molecular tool.Neuropharmacology, , Volume: 76 Pt A, 2014
Neuroprotective effects of extract of Acanthopanax senticosus harms on SH-SY5Y cells overexpressing wild-type or A53T mutant α-synuclein.Phytomedicine : international journal of phytotherapy and phytopharmacology, , Apr-15, Volume: 21, Issue:5, 2014
Cheek cell-derived α-synuclein and DJ-1 do not differentiate Parkinson's disease from control.Neurobiology of aging, , Volume: 35, Issue:2, 2014
Management of the aging risk factor for Parkinson's disease.Neurobiology of aging, , Volume: 35, Issue:4, 2014
Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys.Annals of neurology, , Volume: 75, Issue:3, 2014
Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson's disease.Acta neuropathologica, , Volume: 127, Issue:2, 2014
Metabolic abnormalities and hypoleptinemia in α-synuclein A53T mutant mice.Neurobiology of aging, , Volume: 35, Issue:5, 2014
Defining the native state of α-synuclein.Neuro-degenerative diseases, , Volume: 13, Issue:2-3, 2014
Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice.Human molecular genetics, , Feb-01, Volume: 23, Issue:3, 2014
Copper pathology in vulnerable brain regions in Parkinson's disease.Neurobiology of aging, , Volume: 35, Issue:4, 2014
α-Synuclein ubiquitination and novel therapeutic targets for Parkinson's disease.CNS & neurological disorders drug targets, , Volume: 13, Issue:4, 2014
α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease.Free radical biology & medicine, , Volume: 67, 2014
α-Synuclein in Parkinson's disease: pathogenic function and translation into animal models.Neuro-degenerative diseases, , Volume: 14, Issue:1, 2014
α-Synuclein in the olfactory system in Parkinson's disease: role of neural connections on spreading pathology.Brain structure & function, , Volume: 219, Issue:5, 2014
The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson's disease.Biochimica et biophysica acta, , Volume: 1842, Issue:1, 2014
Immunohistochemical localization of spatacsin in α-synucleinopathies.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 34, Issue:2, 2014
α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?Acta neuropathologica, , Volume: 125, Issue:5, 2013
Binding of the radioligand SIL23 to α-synuclein fibrils in Parkinson disease brain tissue establishes feasibility and screening approaches for developing a Parkinson disease imaging agent.PloS one, , Volume: 8, Issue:2, 2013
A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats.Brain : a journal of neurology, , Volume: 136, Issue:Pt 2, 2013
May the evaluation of nitrosative stress through selective increase of 3-nitrotyrosine proteins other than nitroalbumin and dominant tyrosine-125/136 nitrosylation of serum α-synuclein serve for diagnosis of sporadic Parkinson's disease?Antioxidants & redox signaling, , Sep-20, Volume: 19, Issue:9, 2013
A novel α-synuclein missense mutation in Parkinson disease.Neurology, , Mar-12, Volume: 80, Issue:11, 2013
Melatonin prevents dopaminergic cell loss induced by lentiviral vectors expressing A30P mutant alpha-synuclein.Histology and histopathology, , Volume: 28, Issue:8, 2013
Mind the gut: secretion of α-synuclein by enteric neurons.Journal of neurochemistry, , Volume: 125, Issue:4, 2013
Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies.Journal of neurochemistry, , Volume: 125, Issue:4, 2013
Role of α-synuclein aggregation and the nuclear factor E2-related factor 2/heme oxygenase-1 pathway in iron-induced neurotoxicity.The international journal of biochemistry & cell biology, , Volume: 45, Issue:6, 2013
Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:6, 2013
Dopamine-mediated oxidation of methionine 127 in α-synuclein causes cytotoxicity and oligomerization of α-synuclein.PloS one, , Volume: 8, Issue:2, 2013
Valproic acid ameliorates C. elegans dopaminergic neurodegeneration with implications for ERK-MAPK signaling.Neuroscience letters, , Apr-29, Volume: 541, 2013
Influence of microRNA deregulation on chaperone-mediated autophagy and α-synuclein pathology in Parkinson's disease.Cell death & disease, , Mar-14, Volume: 4, 2013
Levodopa gains psychostimulant-like properties after nigral dopaminergic loss.Annals of neurology, , Volume: 74, Issue:1, 2013
Exploring the accessible conformations of N-terminal acetylated α-synuclein.FEBS letters, , Apr-17, Volume: 587, Issue:8, 2013
Neuroprotective effects of aqueous extracts of Uncaria tomentosa: Insights from 6-OHDA induced cell damage and transgenic Caenorhabditis elegans model.Neurochemistry international, , Volume: 62, Issue:7, 2013
Site-specific perturbations of alpha-synuclein fibril structure by the Parkinson's disease associated mutations A53T and E46K.PloS one, , Volume: 8, Issue:3, 2013
Neuroimmunological processes in Parkinson's disease and their relation to α-synuclein: microglia as the referee between neuronal processes and peripheral immunity.ASN neuro, , Apr-30, Volume: 5, Issue:2, 2013
α-Synuclein-mediated defense against oxidative stress via modulation of glutathione peroxidase.Biochimica et biophysica acta, , Volume: 1834, Issue:6, 2013
Genetic susceptibility loci, environmental exposures, and Parkinson's disease: a case-control study of gene-environment interactions.Parkinsonism & related disorders, , Volume: 19, Issue:6, 2013
Early Alzheimer's and Parkinson's disease pathology in urban children: Friend versus Foe responses--it is time to face the evidence.BioMed research international, , Volume: 2013, 2013
Curcumin modulates α-synuclein aggregation and toxicity.ACS chemical neuroscience, , Mar-20, Volume: 4, Issue:3, 2013
On-surface aggregation of α-synuclein at nanomolar concentrations results in two distinct growth mechanisms.ACS chemical neuroscience, , Mar-20, Volume: 4, Issue:3, 2013
α-Synuclein and mitochondria: partners in crime?Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 10, Issue:3, 2013
Chronic intranasal deferoxamine ameliorates motor defects and pathology in the α-synuclein rAAV Parkinson's model.Experimental neurology, , Volume: 247, 2013
Lewy body-like α-synuclein aggregates resist degradation and impair macroautophagy.The Journal of biological chemistry, , May-24, Volume: 288, Issue:21, 2013
Specific pesticide-dependent increases in α-synuclein levels in human neuroblastoma (SH-SY5Y) and melanoma (SK-MEL-2) cell lines.Toxicological sciences : an official journal of the Society of Toxicology, , Volume: 133, Issue:2, 2013
[Neurotoxicity of pesticides: its relationship with neurodegenerative diseases].Medecine sciences : M/S, , Volume: 29, Issue:3, 2013
Behavioral testing regimens in genetic-based animal models of Parkinson's disease: cogencies and caveats.Neuroscience and biobehavioral reviews, , Volume: 37, Issue:5, 2013
Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function.PloS one, , Volume: 8, Issue:4, 2013
Prolyl oligopeptidase colocalizes with α-synuclein, β-amyloid, tau protein and astroglia in the post-mortem brain samples with Parkinson's and Alzheimer's diseases.Neuroscience, , Jul-09, Volume: 242, 2013
Lewy body pathology is associated with mitochondrial DNA damage in Parkinson's disease.Neurobiology of aging, , Volume: 34, Issue:9, 2013
Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease.Neurobiology of disease, , Volume: 56, 2013
Rasagiline ameliorates olfactory deficits in an alpha-synuclein mouse model of Parkinson's disease.PloS one, , Volume: 8, Issue:4, 2013
Loss of β-glucocerebrosidase activity does not affect alpha-synuclein levels or lysosomal function in neuronal cells.PloS one, , Volume: 8, Issue:4, 2013
α-Synuclein: the long distance runner.Brain pathology (Zurich, Switzerland), , Volume: 23, Issue:3, 2013
Crosstalk between the proteasome system and autophagy in the clearance of α-synuclein.Acta pharmacologica Sinica, , Volume: 34, Issue:5, 2013
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease.Acta neuropathologica, , Volume: 125, Issue:6, 2013
Structures and free energy landscapes of the A53T mutant-type α-synuclein protein and impact of A53T mutation on the structures of the wild-type α-synuclein protein with dynamics.ACS chemical neuroscience, , Jul-17, Volume: 4, Issue:7, 2013
Inhibition of formation of α-synuclein inclusions by mannosylglycerate in a yeast model of Parkinson's disease.Biochimica et biophysica acta, , Volume: 1830, Issue:8, 2013
TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity.Proceedings of the National Academy of Sciences of the United States of America, , May-07, Volume: 110, Issue:19, 2013
Alpha-synuclein and intracellular trafficking: impact on the spreading of Parkinson's disease pathology.Journal of molecular medicine (Berlin, Germany), , Volume: 91, Issue:6, 2013
High-resolution survey in familial Parkinson disease genes reveals multiple independent copy number variation events in PARK2.Human mutation, , Volume: 34, Issue:8, 2013
Parkinsonism, dementia and glucocerebrosidase mutations.Journal of neurology, , Volume: 260, Issue:5, 2013
Development and screening of contrast agents for in vivo imaging of Parkinson's disease.Molecular imaging and biology, , Volume: 15, Issue:5, 2013
TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease.PloS one, , Volume: 8, Issue:4, 2013
Molecular ageing of alpha- and Beta-synucleins: protein damage and repair mechanisms.PloS one, , Volume: 8, Issue:4, 2013
A blood-brain barrier (BBB) disrupter is also a potent α-synuclein (α-syn) aggregation inhibitor: a novel dual mechanism of mannitol for the treatment of Parkinson disease (PD).The Journal of biological chemistry, , Jun-14, Volume: 288, Issue:24, 2013
Small molecules interacting with α-synuclein: antiaggregating and cytoprotective properties.Amino acids, , Volume: 45, Issue:2, 2013
The remarkable conformational plasticity of alpha-synuclein: blessing or curse?Trends in molecular medicine, , Volume: 19, Issue:6, 2013
FBXO7 immunoreactivity in α-synuclein-containing inclusions in Parkinson disease and multiple system atrophy.Journal of neuropathology and experimental neurology, , Volume: 72, Issue:6, 2013
SNCA: major genetic modifier of age at onset of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:9, 2013
The many faces of alpha-synuclein mutations.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:6, 2013
Somatic alpha-synuclein mutations in Parkinson's disease: hypothesis and preliminary data.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:6, 2013
A mir-153 binding site variation in SNCA in a patient with Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:12, 2013
Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 27, Issue:9, 2013
RNA interference targeting α-synuclein attenuates methamphetamine-induced neurotoxicity in SH-SY5Y cells.Brain research, , Jul-12, Volume: 1521, 2013
Caudo-rostral brain spreading of α-synuclein through vagal connections.EMBO molecular medicine, , Volume: 5, Issue:7, 2013
Mitochondria and quality control defects in a mouse model of Gaucher disease--links to Parkinson's disease.Cell metabolism, , Jun-04, Volume: 17, Issue:6, 2013
Tenuigenin attenuates α-synuclein-induced cytotoxicity by down-regulating polo-like kinase 3.CNS neuroscience & therapeutics, , Volume: 19, Issue:9, 2013
Conformational templating of α-synuclein aggregates in neuronal-glial cultures.Molecular neurodegeneration, , May-28, Volume: 8, 2013
SNCA rs356219 variant increases risk of sporadic Parkinson's disease in ethnic Chinese.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, , Volume: 162B, Issue:5, 2013
MHCII is required for α-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jun-05, Volume: 33, Issue:23, 2013
Reprint of: revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease-resemblance to the effect of amphetamine drugs of abuse.Free radical biology & medicine, , Volume: 62, 2013
Castration induces Parkinson disease pathologies in young male mice via inducible nitric-oxide synthase.The Journal of biological chemistry, , Jul-19, Volume: 288, Issue:29, 2013
Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases.Neurobiology of disease, , Volume: 58, 2013
Applying chaperones to protein-misfolding disorders: molecular chaperones against α-synuclein in Parkinson's disease.International journal of biological macromolecules, , Volume: 60, 2013
Parkinson disease affects peripheral sensory nerves in the pharynx.Journal of neuropathology and experimental neurology, , Volume: 72, Issue:7, 2013
α-Synuclein vaccination prevents the accumulation of parkinson disease-like pathologic inclusions in striatum in association with regulatory T cell recruitment in a rat model.Journal of neuropathology and experimental neurology, , Volume: 72, Issue:7, 2013
Exosomes of BV-2 cells induced by alpha-synuclein: important mediator of neurodegeneration in PD.Neuroscience letters, , Aug-26, Volume: 548, 2013
Binding of Dopamine to Alpha-Synuclein is Mediated by Specific Conformational States.Journal of the American Society for Mass Spectrometry, , Volume: 24, Issue:9, 2013
Adsorption of α-synuclein to supported lipid bilayers: positioning and role of electrostatics.ACS chemical neuroscience, , Oct-16, Volume: 4, Issue:10, 2013
Distinct α-synuclein strains differentially promote tau inclusions in neurons.Cell, , Jul-03, Volume: 154, Issue:1, 2013
SNCA, LRRK2, MAPT polymorphisms and Parkinson's disease in Russia.Parkinsonism & related disorders, , Volume: 19, Issue:11, 2013
Membrane bound α-synuclein is fully embedded in the lipid bilayer while segments with higher flexibility remain.FEBS letters, , Aug-19, Volume: 587, Issue:16, 2013
[The relevance between the import roles for alpha-synuclein in neurotransmitter release and the progress of Parkinsons disease].Sheng li ke xue jin zhan [Progress in physiology], , Volume: 44, Issue:6, 2013
The glial marker YKL-40 is decreased in synucleinopathies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:13, 2013
Analysis of genome-wide association study-linked loci in Parkinson's disease of Mainland China.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:13, 2013
C9ORF72 expansions, parkinsonism, and Parkinson disease: a clinicopathologic study.Neurology, , Aug-27, Volume: 81, Issue:9, 2013
Deregulation of calcium homeostasis mediates secreted α-synuclein-induced neurotoxicity.Neurobiology of aging, , Volume: 34, Issue:12, 2013
The role of α-synuclein in neurodegenerative diseases: from molecular pathways in disease to therapeutic approaches.Current Alzheimer research, , Volume: 10, Issue:6, 2013
Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies.Nature reviews. Neuroscience, , Volume: 14, Issue:9, 2013
A peroxisome biogenesis deficiency prevents the binding of alpha-synuclein to lipid droplets in lipid-loaded yeast.Biochemical and biophysical research communications, , Aug-23, Volume: 438, Issue:2, 2013
Novel A18T and pA29S substitutions in α-synuclein may be associated with sporadic Parkinson's disease.Parkinsonism & related disorders, , Volume: 19, Issue:11, 2013
α-Synuclein is a pathological link and therapeutic target for Parkinson's disease and traumatic brain injury.Medical hypotheses, , Volume: 81, Issue:4, 2013
Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice.Acta neuropathologica, , Volume: 126, Issue:4, 2013
Alpha-synuclein: one key opens many locks.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:9, 2013
Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease.PloS one, , Volume: 8, Issue:8, 2013
Autophagic impairment contributes to systemic inflammation-induced dopaminergic neuron loss in the midbrain.PloS one, , Volume: 8, Issue:8, 2013
The benefits of humanized yeast models to study Parkinson's disease.Oxidative medicine and cellular longevity, , Volume: 2013, 2013
Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice.Molecular brain, , Aug-11, Volume: 6, 2013
Treatment implications of the altered cytokine-insulin axis in neurodegenerative disease.Biochemical pharmacology, , Oct-01, Volume: 86, Issue:7, 2013
Parkinson's disease: "Braak" to the future.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:9, 2013
Ubiquitination increases parkin activity to promote autophagic α-synuclein clearance.PloS one, , Volume: 8, Issue:12, 2013
Alpha-synuclein post-translational modifications as potential biomarkers for Parkinson disease and other synucleinopathies.Molecular & cellular proteomics : MCP, , Volume: 12, Issue:12, 2013
[Hyperbranching axons template α-synuclein deposits and non-localizing clinical manifestations of Parkinson disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 65, Issue:12, 2013
Association of cerebrospinal fluid β-amyloid 1-42, T-tau, P-tau181, and α-synuclein levels with clinical features of drug-naive patients with early Parkinson disease.JAMA neurology, , Volume: 70, Issue:10, 2013
Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathies.Acta neuropathologica communications, , Dec-05, Volume: 1, 2013
SUMO and Parkinson's disease.Neuromolecular medicine, , Volume: 15, Issue:4, 2013
Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription.Cell, , Dec-05, Volume: 155, Issue:6, 2013
Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo.Proceedings of the National Academy of Sciences of the United States of America, , Oct-08, Volume: 110, Issue:41, 2013
A longitudinal study on α-synuclein in blood plasma as a biomarker for Parkinson's disease.Scientific reports, , Volume: 3, 2013
Limelight on alpha-synuclein: pathological and mechanistic implications in neurodegeneration.Journal of Parkinson's disease, , Volume: 3, Issue:4, 2013
Can intrabodies serve as neuroprotective therapies for Parkinson's disease? Beginning thoughts.Journal of Parkinson's disease, , Volume: 3, Issue:4, 2013
rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration.Molecular neurodegeneration, , Nov-25, Volume: 8, 2013
Association between early-onset Parkinson disease and 22q11.2 deletion syndrome: identification of a novel genetic form of Parkinson disease and its clinical implications.JAMA neurology, , Volume: 70, Issue:11, 2013
α-Synuclein as a ferrireductase.Biochemical Society transactions, , Volume: 41, Issue:6, 2013
Emerging insights into the mechanistic link between α-synuclein and glucocerebrosidase in Parkinson's disease.Biochemical Society transactions, , Volume: 41, Issue:6, 2013
The role of oxidative stress in Parkinson's disease.Journal of Parkinson's disease, , Volume: 3, Issue:4, 2013
ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies.Acta neuropathologica communications, , May-09, Volume: 1, 2013
Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells.International journal of molecular sciences, , Nov-15, Volume: 14, Issue:11, 2013
Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology.Proceedings of the National Academy of Sciences of the United States of America, , Oct-29, Volume: 110, Issue:44, 2013
The Parkinson's disease-associated H50Q mutation accelerates α-Synuclein aggregation in vitro.Biochemistry, , Oct-08, Volume: 52, Issue:40, 2013
Phenotypic screens for compounds that target the cellular pathologies underlying Parkinson's disease.Drug discovery today. Technologies, ,Spring, Volume: 10, Issue:1, 2013
The function of α-synuclein.Neuron, , Sep-18, Volume: 79, Issue:6, 2013
A single dopamine pathway underlies progressive locomotor deficits in a Drosophila model of Parkinson disease.Cell reports, , Nov-27, Volume: 5, Issue:4, 2013
Influence of gold nanoparticles on the kinetics of α-synuclein aggregation.Nano letters, , Volume: 13, Issue:12, 2013
Neuroprotective effects of protocatechuic aldehyde against neurotoxin-induced cellular and animal models of Parkinson's disease.PloS one, , Volume: 8, Issue:10, 2013
Off-pathway α-synuclein oligomers seem to alter α-synuclein turnover in a cell model but lack seeding capability in vivo.Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, , Volume: 20, Issue:4, 2013
SMG1 identified as a regulator of Parkinson's disease-associated alpha-synuclein through siRNA screening.PloS one, , Volume: 8, Issue:10, 2013
Parkinson's disease: dopaminergic nerve cell model is consistent with experimental finding of increased extracellular transport of α-synuclein.BMC neuroscience, , Nov-06, Volume: 14, 2013
[Impacts of electroacupuncture on ubiquitin-proteasome system in rats with Parkinson's disease].Zhongguo zhen jiu = Chinese acupuncture & moxibustion, , Volume: 33, Issue:8, 2013
Elevated alpha-synuclein impairs innate immune cell function and provides a potential peripheral biomarker for Parkinson's disease.PloS one, , Volume: 8, Issue:8, 2013
α-synuclein imaging: a critical need for Parkinson's disease research.Journal of Parkinson's disease, , Volume: 3, Issue:4, 2013
Mechanistic insight into the relationship between N-terminal acetylation of α-synuclein and fibril formation rates by NMR and fluorescence.PloS one, , Volume: 8, Issue:9, 2013
Dexamethasone induces the expression of LRRK2 and α-synuclein, two genes that when mutated cause Parkinson's disease in an autosomal dominant manner.BMB reports, , Volume: 46, Issue:9, 2013
Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice.BMC neuroscience, , Nov-05, Volume: 14, 2013
α-Synuclein misfolding assessed with single molecule AFM force spectroscopy: effect of pathogenic mutations.Biochemistry, , Oct-22, Volume: 52, Issue:42, 2013
[The role of extracellular α-synuclein in molecular mechanisms of cell death].Postepy higieny i medycyny doswiadczalnej (Online), , Nov-04, Volume: 67, 2013
In vivo electrophysiology of nigral and thalamic neurons in alpha-synuclein-overexpressing mice highlights differences from toxin-based models of parkinsonism.Journal of neurophysiology, , Volume: 110, Issue:12, 2013
Saposin C protects glucocerebrosidase against α-synuclein inhibition.Biochemistry, , Oct-15, Volume: 52, Issue:41, 2013
Silencing synuclein at the synapse with PLK2.Proceedings of the National Academy of Sciences of the United States of America, , Oct-08, Volume: 110, Issue:41, 2013
Endonuclease-G and the pathways to dopaminergic neurodegeneration: a question of location?The EMBO journal, , Nov-27, Volume: 32, Issue:23, 2013
Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.Science (New York, N.Y.), , Nov-22, Volume: 342, Issue:6161, 2013
Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.Science (New York, N.Y.), , Nov-22, Volume: 342, Issue:6161, 2013
Identification of the sites of tau hyperphosphorylation and activation of tau kinases in synucleinopathies and Alzheimer's diseases.PloS one, , Volume: 8, Issue:9, 2013
Ankyrin repeat and BTB/POZ domain containing protein-2 inhibits the aggregation of alpha-synuclein: implications for Parkinson's disease.FEBS letters, , Nov-01, Volume: 587, Issue:21, 2013
LAMP2A as a therapeutic target in Parkinson disease.Autophagy, , Volume: 9, Issue:12, 2013
Breaking the limits of artificial ubiquitination.Proceedings of the National Academy of Sciences of the United States of America, , Oct-29, Volume: 110, Issue:44, 2013
In-silico analysis for RNA-interference mechanism of α-synuclein to treat Parkinson's disease.International journal of bioinformatics research and applications, , Volume: 9, Issue:6, 2013
Hypercoagulability, parkinsonism, and Gaucher disease.Seminars in thrombosis and hemostasis, , Volume: 39, Issue:8, 2013
α-Synuclein in cutaneous autonomic nerves.Neurology, , Oct-29, Volume: 81, Issue:18, 2013
Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease.The EMBO journal, , Nov-27, Volume: 32, Issue:23, 2013
Is α-synuclein rising to the surface as a diagnostic biomarker for Parkinson disease?Neurology, , Oct-29, Volume: 81, Issue:18, 2013
A conformation-switching fluorescent protein probe for detection of alpha synuclein oligomers.Chemical communications (Cambridge, England), , Nov-25, Volume: 49, Issue:91, 2013
Modulation of α-synuclein fibrillization by ring-fused 2-pyridones: templation and inhibition involve oligomers with different structure.Archives of biochemistry and biophysics, , Apr-15, Volume: 532, Issue:2, 2013
Mapping the subcellular distribution of α-synuclein in neurons using genetically encoded probes for correlated light and electron microscopy: implications for Parkinson's disease pathogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-06, Volume: 33, Issue:6, 2013
Parkinson's disease and alpha synuclein: is Parkinson's disease a prion-like disorder?Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:1, 2013
The genetics of Parkinson's disease: progress and therapeutic implications.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:1, 2013
Assessing the subcellular dynamics of alpha-synuclein using photoactivation microscopy.Molecular neurobiology, , Volume: 47, Issue:3, 2013
Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies.PloS one, , Volume: 8, Issue:1, 2013
Pale body-like inclusion formation and neurodegeneration following depletion of 26S proteasomes in mouse brain neurones are independent of α-synuclein.PloS one, , Volume: 8, Issue:1, 2013
Evaluation of potential infectivity of Alzheimer and Parkinson disease proteins in recipients of cadaver-derived human growth hormone.JAMA neurology, , Volume: 70, Issue:4, 2013
Parkinson disease: from pathology to molecular disease mechanisms.Free radical biology & medicine, , Volume: 62, 2013
Neural and immune mechanisms in the pathogenesis of Parkinson's disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 8, Issue:1, 2013
The association between lysosomal protein glucocerebrosidase and Parkinson's disease.European review for medical and pharmacological sciences, , Volume: 17, Issue:2, 2013
Disturbed sleep in Parkinson's disease: anatomical and pathological correlates.Neuropathology and applied neurobiology, , Volume: 39, Issue:6, 2013
Enteric alpha-synuclein expression is increased in Parkinson's disease but not Alzheimer's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:2, 2013
α-Synuclein and mitochondrial dysfunction in Parkinson's disease.Molecular neurobiology, , Volume: 47, Issue:2, 2013
An ERcentric view of Parkinson's disease.Trends in molecular medicine, , Volume: 19, Issue:3, 2013
Temperature-dependent structural changes of Parkinson's alpha-synuclein reveal the role of pre-existing oligomers in alpha-synuclein fibrillization.PloS one, , Volume: 8, Issue:1, 2013
Aggregation and neurotoxicity of recombinant α-synuclein aggregates initiated by dimerization.Molecular neurodegeneration, , Jan-22, Volume: 8, 2013
Nuclear translocation of alpha-synuclein increases susceptibility of MES23.5 cells to oxidative stress.Brain research, , Mar-15, Volume: 1500, 2013
Submandibular gland biopsy for the diagnosis of Parkinson disease.Journal of neuropathology and experimental neurology, , Volume: 72, Issue:2, 2013
Alpha-synuclein pathology and axonal degeneration of the peripheral motor nerves innervating pharyngeal muscles in Parkinson disease.Journal of neuropathology and experimental neurology, , Volume: 72, Issue:2, 2013
The secreted oligomeric form of α-synuclein affects multiple steps of membrane trafficking.FEBS letters, , Mar-01, Volume: 587, Issue:5, 2013
Gender differences in Parkinson's disease: focus on plasma α-synuclein.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 120, Issue:8, 2013
Curcumin ameliorates the neurodegenerative pathology in A53T α-synuclein cell model of Parkinson's disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 8, Issue:1, 2013
The role of Ser129 phosphorylation of α-synuclein in neurodegeneration of Parkinson's disease: a review of in vivo models.Reviews in the neurosciences, , Volume: 24, Issue:2, 2013
Low CSF levels of both α-synuclein and the α-synuclein cleaving enzyme neurosin in patients with synucleinopathy.PloS one, , Volume: 8, Issue:1, 2013
The behavioural and neuropathological impact of intranigral AAV-α-synuclein is exacerbated by systemic infusion of the Parkinson's disease-associated pesticide, rotenone, in rats.Behavioural brain research, , Apr-15, Volume: 243, 2013
Activity-dependent secretion of alpha-synuclein by enteric neurons.Journal of neurochemistry, , Volume: 125, Issue:4, 2013
In vivo neurochemical imaging of olfactory dysfunction in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 120, Issue:4, 2013
Commentary: Progressive inflammation as a contributing factor to early development of Parkinson's disease.Experimental neurology, , Volume: 241, 2013
Naturally occurring α-synuclein autoantibody levels are lower in patients with Parkinson disease.Neurology, , Jan-08, Volume: 80, Issue:2, 2013
Coordination of copper to the membrane-bound form of α-synuclein.Biochemistry, , Jan-08, Volume: 52, Issue:1, 2013
α-Synuclein oligomers and clinical implications for Parkinson disease.Annals of neurology, , Volume: 73, Issue:2, 2013
Changes in properties of serine 129 phosphorylated α-synuclein with progression of Lewy-type histopathology in human brains.Experimental neurology, , Volume: 240, 2013
Monomeric synucleins generate membrane curvature.The Journal of biological chemistry, , Jan-18, Volume: 288, Issue:3, 2013
100 years of Lewy pathology.Nature reviews. Neurology, , Volume: 9, Issue:1, 2013
LRRK2 interactions with α-synuclein in Parkinson's disease brains and in cell models.Journal of molecular medicine (Berlin, Germany), , Volume: 91, Issue:4, 2013
Genetic variants of SNCA and LRRK2 genes are associated with sporadic PD susceptibility: a replication study in a Taiwanese cohort.Parkinsonism & related disorders, , Volume: 19, Issue:2, 2013
The central theme of Parkinson's disease: α-synuclein.Molecular neurobiology, , Volume: 47, Issue:2, 2013
Comparison of the structural characteristics of Cu(2+)-bound and unbound α-syn12 peptide obtained in simulations using different force fields.Journal of molecular modeling, , Volume: 19, Issue:3, 2013
The Ca2+/Mn2+ ion-pump PMR1 links elevation of cytosolic Ca(2+) levels to α-synuclein toxicity in Parkinson's disease models.Cell death and differentiation, , Volume: 20, Issue:3, 2013
Total CSF α-synuclein is lower in de novo Parkinson patients than in healthy subjects.Neuroscience letters, , Jan-04, Volume: 532, 2013
Dysfunction of the locus coeruleus-norepinephrine system and related circuitry in Parkinson's disease-related dementia.Journal of neurology, neurosurgery, and psychiatry, , Volume: 84, Issue:7, 2013
Microglial activation and antioxidant responses induced by the Parkinson's disease protein α-synuclein.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 8, Issue:1, 2013
Delay discounting of reward and caudate nucleus volume in individuals with α-synuclein gene duplication before and after the development of Parkinson's disease.Neuro-degenerative diseases, , Volume: 11, Issue:2, 2013
Cardiac sympathetic denervation in symptomatic and asymptomatic carriers of the E46K mutation in the α synuclein gene.Parkinsonism & related disorders, , Volume: 19, Issue:1, 2013
Personalized medicine strategies for managing patients with parkinsonism and cognitive deficits.Metabolism: clinical and experimental, , Volume: 62 Suppl 1, 2013
Identification and quantification of oligodendrocyte precursor cells in multiple system atrophy, progressive supranuclear palsy and Parkinson's disease.Brain pathology (Zurich, Switzerland), , Volume: 23, Issue:3, 2013
α-Synuclein and protein degradation systems: a reciprocal relationship.Molecular neurobiology, , Volume: 47, Issue:2, 2013
α-Synuclein and neuronal cell death.Molecular neurobiology, , Volume: 47, Issue:2, 2013
Recent advances in α-synuclein functions, advanced glycation, and toxicity: implications for Parkinson's disease.Molecular neurobiology, , Volume: 47, Issue:2, 2013
Dietary energy intake modifies brainstem autonomic dysfunction caused by mutant α-synuclein.Neurobiology of aging, , Volume: 34, Issue:3, 2013
The potential prognostic role of cardiovascular autonomic failure in α-synucleinopathies.European journal of neurology, , Volume: 20, Issue:2, 2013
Selective expression of α-synuclein-immunoreactivity in vesicular acetylcholine transporter-immunoreactive axons in the guinea pig rectum and human colon.The Journal of comparative neurology, , Feb-15, Volume: 521, Issue:3, 2013
Neuronal vulnerability, pathogenesis, and Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:1, 2013
Adult neurogenesis in Parkinson's disease.Cellular and molecular life sciences : CMLS, , Volume: 70, Issue:3, 2013
Animal models of Parkinson's disease: limits and relevance to neuroprotection studies.Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:1, 2013
Neuropathologic analysis of Lewy-related α-synucleinopathy in olfactory mucosa.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 33, Issue:1, 2013
The Lewy body in Parkinson's disease and related neurodegenerative disorders.Molecular neurobiology, , Volume: 47, Issue:2, 2013
Impairment of the septal cholinergic neurons in MPTP-treated A30P α-synuclein mice.Neurobiology of aging, , Volume: 34, Issue:2, 2013
Inflammation and α-synuclein's prion-like behavior in Parkinson's disease--is there a link?Molecular neurobiology, , Volume: 47, Issue:2, 2013
Can Parkinson's disease pathology be propagated from one neuron to another?Progress in neurobiology, , Volume: 97, Issue:2, 2012
SNCA and MAPT genes: Independent and joint effects in Parkinson disease in the Italian population.Parkinsonism & related disorders, , Volume: 18, Issue:3, 2012
Genetic and pathological links between Parkinson's disease and the lysosomal disorder Sanfilippo syndrome.Movement disorders : official journal of the Movement Disorder Society, , Volume: 27, Issue:2, 2012
Phosphorylated α-synuclein immunoreactivity in the posterior pituitary lobe.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 32, Issue:4, 2012
Neuropathology of sporadic Parkinson's disease: evaluation and changes of concepts.Movement disorders : official journal of the Movement Disorder Society, , Volume: 27, Issue:1, 2012
A search for SNCA 3' UTR variants identified SNP rs356165 as a determinant of disease risk and onset age in Parkinson's disease.Journal of molecular neuroscience : MN, , Volume: 47, Issue:3, 2012
Α-synuclein misfolding and Parkinson's disease.Biochimica et biophysica acta, , Volume: 1822, Issue:2, 2012
Inclusion of a portion of the native SNCA 3'UTR reduces toxicity of human S129A SNCA on striatal-projecting dopamine neurons in rat substantia nigra.Developmental neurobiology, , Volume: 72, Issue:6, 2012
DJ-1 and αSYN in LRRK2 CSF do not correlate with striatal dopaminergic function.Neurobiology of aging, , Volume: 33, Issue:4, 2012
Autonomic involvement in Parkinson's disease: pathology, pathophysiology, clinical features and possible peripheral biomarkers.Journal of the neurological sciences, , Feb-15, Volume: 313, Issue:1-2, 2012
A53T-alpha-synuclein-overexpression in the mouse nigrostriatal pathway leads to early increase of 14-3-3 epsilon and late increase of GFAP.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 119, Issue:3, 2012
Α-synuclein neuropathology is controlled by nuclear hormone receptors and enhanced by docosahexaenoic acid in a mouse model for Parkinson's disease.Brain pathology (Zurich, Switzerland), , Volume: 22, Issue:3, 2012
α-Synuclein in the olfactory system of a mouse model of Parkinson's disease: correlation with olfactory projections.Brain structure & function, , Volume: 217, Issue:2, 2012
Post mortem cerebrospinal fluid α-synuclein levels are raised in multiple system atrophy and distinguish this from the other α-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies.Neurobiology of disease, , Volume: 45, Issue:1, 2012
Mitochondrial dysfunction in genetic animal models of Parkinson's disease.Antioxidants & redox signaling, , May-01, Volume: 16, Issue:9, 2012
Involvement of the spinal cord in Parkinson's disease.The International journal of neuroscience, , Volume: 122, Issue:1, 2012
Biophysics of α-synuclein membrane interactions.Biochimica et biophysica acta, , Volume: 1818, Issue:2, 2012
Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 22, Issue:1, 2012
Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 27, Issue:6, 2012
Successful subthalamic stimulation in genetic Parkinson's disease caused by duplication of the α-synuclein gene.Journal of neurology, , Volume: 259, Issue:1, 2012
Pale neurites, premature α-synuclein aggregates with centripetal extension from axon collaterals.Brain pathology (Zurich, Switzerland), , Volume: 22, Issue:1, 2012
CSF α-synuclein does not differentiate between parkinsonian disorders.Neurobiology of aging, , Volume: 33, Issue:2, 2012
[Analysis of the rs12720208 single-nucleotide polymorphism of the FGF20 gene in Russian patients with sporadic Parkinson's disease].Genetika, , Volume: 48, Issue:12, 2012
Loss of functional alpha-synuclein: a toxic event in Parkinson's disease?Journal of Parkinson's disease, , Volume: 2, Issue:4, 2012
Changes in sphingomyelin level affect alpha-synuclein and ABCA5 expression.Journal of Parkinson's disease, , Volume: 2, Issue:1, 2012
Αlpha-synuclein levels in blood plasma from LRRK2 mutation carriers.PloS one, , Volume: 7, Issue:12, 2012
α-Synuclein and anti-α-synuclein antibodies in Parkinson's disease, atypical Parkinson syndromes, REM sleep behavior disorder, and healthy controls.PloS one, , Volume: 7, Issue:12, 2012
Covalent α-synuclein dimers: chemico-physical and aggregation properties.PloS one, , Volume: 7, Issue:12, 2012
Changes in selenoprotein P in substantia nigra and putamen in Parkinson's disease.Journal of Parkinson's disease, , Volume: 2, Issue:2, 2012
[The Parkinson puzzle].Orvosi hetilap, , Dec-30, Volume: 153, Issue:52, 2012
Parkinson's disease.Sub-cellular biochemistry, , Volume: 65, 2012
α-Synuclein aggregation and modulating factors.Sub-cellular biochemistry, , Volume: 65, 2012
Astrocyte-specific overexpression of Nrf2 delays motor pathology and synuclein aggregation throughout the CNS in the alpha-synuclein mutant (A53T) mouse model.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Dec-05, Volume: 32, Issue:49, 2012
Molecular simulations of the fluctuating conformational dynamics of intrinsically disordered proteins.Physical review. E, Statistical, nonlinear, and soft matter physics, , Volume: 86, Issue:4 Pt 1, 2012
Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate.Scientific reports, , Volume: 2, 2012
Accumulation of α-synuclein triggered by presynaptic dysfunction.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-28, Volume: 32, Issue:48, 2012
[Aiming to develop biochemical biomarkers for Parkinson's disease and related disorders].Rinsho shinkeigaku = Clinical neurology, , Volume: 52, Issue:11, 2012
Development and characterization of a new Parkinson's disease model resulting from impaired autophagy.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-14, Volume: 32, Issue:46, 2012
An intrinsically disordered region of the acetyltransferase p300 with similarity to prion-like domains plays a role in aggregation.PloS one, , Volume: 7, Issue:11, 2012
Radiating amyloid fibril formation on the surface of lipid membranes through unit-assembly of oligomeric species of α-synuclein.PloS one, , Volume: 7, Issue:10, 2012
NADPH oxidase 1 mediates α-synucleinopathy in Parkinson's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Oct-17, Volume: 32, Issue:42, 2012
Physical training exerts neuroprotective effects in the regulation of neurochemical factors in an animal model of Parkinson's disease.Neuroscience, , Dec-27, Volume: 227, 2012
Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue.Molecular brain, , Oct-06, Volume: 5, 2012
Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains.Annals of neurology, , Volume: 72, Issue:3, 2012
The role of alpha-synuclein in melanin synthesis in melanoma and dopaminergic neuronal cells.PloS one, , Volume: 7, Issue:9, 2012
Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease.Molecular neurodegeneration, , Sep-28, Volume: 7, 2012
Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H β-synuclein.Molecular brain, , Sep-26, Volume: 5, 2012
Alternative α-synuclein transcript usage as a convergent mechanism in Parkinson's disease pathology.Nature communications, , Volume: 3, 2012
Prenatal exposure to methanol as a dopamine system sensitization model in C57BL/6J mice.Life sciences, , Nov-02, Volume: 91, Issue:19-20, 2012
α-Synuclein disrupts stress signaling by inhibiting polo-like kinase Cdc5/Plk2.Proceedings of the National Academy of Sciences of the United States of America, , Oct-02, Volume: 109, Issue:40, 2012
Correlation between protective immunity to α-synuclein aggregates, oxidative stress and inflammation.Neuroimmunomodulation, , Volume: 19, Issue:6, 2012
Dysfunction of two lysosome degradation pathways of α-synuclein in Parkinson's disease: potential therapeutic targets?Neuroscience bulletin, , Volume: 28, Issue:5, 2012
Parkinson's disease is not associated with gastrointestinal myenteric ganglion neuron loss.Acta neuropathologica, , Volume: 124, Issue:5, 2012
Lysosome-dependent pathways as a unifying theme in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Sep-15, Volume: 27, Issue:11, 2012
Spinal cord lesions in sporadic Parkinson's disease.Acta neuropathologica, , Volume: 124, Issue:5, 2012
Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders.Archives of neurology, , Volume: 69, Issue:11, 2012
Recommendations to standardize preanalytical confounding factors in Alzheimer's and Parkinson's disease cerebrospinal fluid biomarkers: an update.Biomarkers in medicine, , Volume: 6, Issue:4, 2012
Evaluation of the role of SNCA variants in survival without neurological disease.PloS one, , Volume: 7, Issue:8, 2012
SF-6 attenuates 6-hydroxydopamine-induced neurotoxicity: an in vitro and in vivo investigation in experimental models of Parkinson's disease.Journal of ethnopharmacology, , Sep-28, Volume: 143, Issue:2, 2012
Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research.PloS one, , Volume: 7, Issue:7, 2012
Silencing of Parkinson's disease-associated genes with artificial mirtron mimics of miR-1224.Nucleic acids research, , Volume: 40, Issue:19, 2012
Novel one-step immunoassays to quantify α-synuclein: applications for biomarker development and high-throughput screening.The Journal of biological chemistry, , Sep-28, Volume: 287, Issue:40, 2012
Identification of protein interfaces between α-synuclein, the principal component of Lewy bodies in Parkinson disease, and the molecular chaperones human Hsc70 and the yeast Ssa1p.The Journal of biological chemistry, , Sep-21, Volume: 287, Issue:39, 2012
Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic.Human molecular genetics, , Nov-01, Volume: 21, Issue:21, 2012
α-Synuclein induces alterations in adult neurogenesis in Parkinson disease models via p53-mediated repression of Notch1.The Journal of biological chemistry, , Sep-14, Volume: 287, Issue:38, 2012
Alpha-synuclein: from secretion to dysfunction and death.Cell death & disease, , Jul-19, Volume: 3, 2012
Pathologic accumulation of α-synuclein and Aβ in Parkinson disease patients with dementia.Archives of neurology, , Volume: 69, Issue:10, 2012
Cognitive impairment in patients with Parkinson's disease: diagnosis, biomarkers, and treatment.The Lancet. Neurology, , Volume: 11, Issue:8, 2012
The genetics and neuropathology of Parkinson's disease.Acta neuropathologica, , Volume: 124, Issue:3, 2012
Inflammation in Parkinson's disease: cause or consequence?Movement disorders : official journal of the Movement Disorder Society, , Volume: 27, Issue:9, 2012
Mice overexpressing wild-type human alpha-synuclein display alterations in colonic myenteric ganglia and defecation.Neurogastroenterology and motility, , Volume: 24, Issue:9, 2012
A model of nitric oxide induced α-synuclein misfolding in Parkinson's disease.Neuroscience letters, , Aug-15, Volume: 523, Issue:2, 2012
Phosphorylation of α-synuclein is crucial in compensating for proteasomal dysfunction.Biochemical and biophysical research communications, , Aug-03, Volume: 424, Issue:3, 2012
Effect of L-ascorbic Acid on the climbing ability and protein levels in the brain of Drosophila model of Parkinson's disease.The International journal of neuroscience, , Volume: 122, Issue:12, 2012
Biomarkers in Parkinson's disease: an update.Current opinion in neurology, , Volume: 25, Issue:4, 2012
First therapy targeting Parkinson's proteins enters clinical trials.Nature medicine, , Jul-06, Volume: 18, Issue:7, 2012
α-Synuclein modulates neurite outgrowth by interacting with SPTBN1.Biochemical and biophysical research communications, , Aug-03, Volume: 424, Issue:3, 2012
Methamphetamine binds to α-synuclein and causes a conformational change which can be detected by nanopore analysis.FEBS letters, , Sep-21, Volume: 586, Issue:19, 2012
The Parkinson's disease-related genes act in mitochondrial homeostasis.Neuroscience and biobehavioral reviews, , Volume: 36, Issue:9, 2012
Remodeling of lipid vesicles into cylindrical micelles by α-synuclein in an extended α-helical conformation.The Journal of biological chemistry, , Aug-24, Volume: 287, Issue:35, 2012
Feedback motif for the pathogenesis of Parkinson's disease.IET systems biology, , Volume: 6, Issue:3, 2012
Dynamic modelling of protein and oxidative metabolisms simulates the pathogenesis of Parkinson's disease.IET systems biology, , Volume: 6, Issue:3, 2012
Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein.Experimental neurology, , Volume: 237, Issue:2, 2012
Protein degradation pathways in Parkinson's disease: curse or blessing.Acta neuropathologica, , Volume: 124, Issue:2, 2012
Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo.PloS one, , Volume: 7, Issue:6, 2012
Cellular and molecular mechanisms of antioxidants in Parkinson's disease.Nutritional neuroscience, , Volume: 15, Issue:3, 2012
Do α-synuclein vector injections provide a better model of Parkinson's disease than the classic 6-hydroxydopamine model?Experimental neurology, , Volume: 237, Issue:1, 2012
Aggregate clearance of α-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome.The Journal of biological chemistry, , Aug-10, Volume: 287, Issue:33, 2012
Alpha-synuclein transgenic mice display age-related slowing of gastrointestinal motility associated with transgene expression in the vagal system.Neurobiology of disease, , Volume: 48, Issue:1, 2012
Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein.The Journal of biological chemistry, , Aug-17, Volume: 287, Issue:34, 2012
Cognitive dysfunction and depression in Parkinson's disease: what can be learned from rodent models?The European journal of neuroscience, , Volume: 35, Issue:12, 2012
[The role of proteins in neurodegenerative disease].Postepy higieny i medycyny doswiadczalnej (Online), , Apr-16, Volume: 66, 2012
Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease.Free radical biology & medicine, , Aug-15, Volume: 53, Issue:4, 2012
Oxidative stress in Alzheimer's and Parkinson's diseases: insights from the yeast Saccharomyces cerevisiae.Oxidative medicine and cellular longevity, , Volume: 2012, 2012
The role of alpha-synuclein oligomerization and aggregation in cellular and animal models of Parkinson's disease.PloS one, , Volume: 7, Issue:6, 2012
Selection of DNA aptamers that recognize α-synuclein oligomers using a competitive screening method.Analytical chemistry, , Jul-03, Volume: 84, Issue:13, 2012
Atomic force microscopy under controlled conditions reveals structure of C-terminal region of α-synuclein in amyloid fibrils.ACS nano, , Jul-24, Volume: 6, Issue:7, 2012
Age at onset in LRRK2-associated PD is modified by SNCA variants.Journal of molecular neuroscience : MN, , Volume: 48, Issue:1, 2012
MiRNAs and neural stem cells: a team to treat Parkinson's disease?RNA biology, , Volume: 9, Issue:6, 2012
Evaluation of the Braak hypothesis: how far can it explain the pathogenesis of Parkinson's disease?Expert review of neurotherapeutics, , Volume: 12, Issue:6, 2012
Lewy pathology in gastric and duodenal biopsies in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 27, Issue:6, 2012
A colonic biomarker of Parkinson's disease?Movement disorders : official journal of the Movement Disorder Society, , Volume: 27, Issue:6, 2012
Genetics and epigenetics of Parkinson's disease.TheScientificWorldJournal, , Volume: 2012, 2012
Proteolytic cleavage of extracellular α-synuclein by plasmin: implications for Parkinson disease.The Journal of biological chemistry, , Jul-20, Volume: 287, Issue:30, 2012
Variants in the 3'UTR of SNCA do not affect miRNA-433 binding and alpha-synuclein expression.European journal of human genetics : EJHG, , Volume: 20, Issue:12, 2012
α-Synuclein genetic variants predict faster motor symptom progression in idiopathic Parkinson disease.PloS one, , Volume: 7, Issue:5, 2012
A brief overview of tyrosine hydroxylase and α-synuclein in the Parkinsonian brain.CNS & neurological disorders drug targets, , Jun-01, Volume: 11, Issue:4, 2012
Current status of tyrosine hydroxylase in management of Parkinson's disease.CNS & neurological disorders drug targets, , Jun-01, Volume: 11, Issue:4, 2012
α-Synuclein expression is modulated at the translational level by iron.Neuroreport, , Jun-20, Volume: 23, Issue:9, 2012
Differential inhibition of α-synuclein oligomeric and fibrillar assembly in parkinson's disease model by cinnamon extract.Biochimica et biophysica acta, , Volume: 1820, Issue:10, 2012
Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson's disease models.Critical reviews in toxicology, , Volume: 42, Issue:7, 2012
N-terminal acetylation of α-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer.Protein science : a publication of the Protein Society, , Volume: 21, Issue:7, 2012
[Role of septin cytoskeleton in dopaminergic neurotransmission and neurodegeneration].Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, , Volume: 32, Issue:1, 2012
Mechanisms underlying the impairment of hippocampal long-term potentiation and memory in experimental Parkinson's disease.Brain : a journal of neurology, , Volume: 135, Issue:Pt 6, 2012
α-Synuclein mRNA and soluble α-synuclein protein levels in post-mortem brain from patients with Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease.Brain research, , Jun-12, Volume: 1459, 2012
From α-synuclein to synaptic dysfunctions: new insights into the pathophysiology of Parkinson's disease.Brain research, , Oct-02, Volume: 1476, 2012
Analysis of colonic alpha-synuclein pathology in multiple system atrophy.Parkinsonism & related disorders, , Volume: 18, Issue:7, 2012
Is alpha-synuclein in the colon a biomarker for premotor Parkinson's disease? Evidence from 3 cases.Movement disorders : official journal of the Movement Disorder Society, , Volume: 27, Issue:6, 2012
Modeling Parkinson's disease using induced pluripotent stem cells.Current neurology and neuroscience reports, , Volume: 12, Issue:3, 2012
Detection of α-synuclein aggregates by fluorescence microscopy.Rejuvenation research, , Volume: 15, Issue:2, 2012
Leucine-rich repeat kinase 2 and alternative splicing in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 27, Issue:8, 2012
Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy.PloS one, , Volume: 7, Issue:4, 2012
α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease.Human molecular genetics, , Jul-15, Volume: 21, Issue:14, 2012
Biochemical premotor biomarkers for Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Apr-15, Volume: 27, Issue:5, 2012
Beyond α-synuclein transfer: pathology propagation in Parkinson's disease.Trends in molecular medicine, , Volume: 18, Issue:5, 2012
Two different binding modes of α-synuclein to lipid vesicles depending on its aggregation state.Biophysical journal, , Apr-04, Volume: 102, Issue:7, 2012
α-Synuclein phosphorylation as a therapeutic target in Parkinson's disease.Reviews in the neurosciences, , Mar-21, Volume: 23, Issue:2, 2012
[Role of microglial activation induced by α-synuclein in pathogenesis of Parkinson's disease].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, , Volume: 41, Issue:2, 2012
A synopsis on the role of tyrosine hydroxylase in Parkinson's disease.CNS & neurological disorders drug targets, , Jun-01, Volume: 11, Issue:4, 2012
New agents promote neuroprotection in Parkinson's disease models.CNS & neurological disorders drug targets, , Jun-01, Volume: 11, Issue:4, 2012
Targeting alpha-synuclein for the treatment of Parkinson's disease.CNS & neurological disorders drug targets, , Volume: 11, Issue:2, 2012
Molecular insights into Parkinson's disease.Progress in molecular biology and translational science, , Volume: 107, 2012
The role of the GABA(B) receptor and calcium channels in a Drosophila model of Parkinson's Disease.Neuroscience letters, , May-16, Volume: 516, Issue:2, 2012
Targeting intracellular and extracellular alpha-synuclein as a therapeutic strategy in Parkinson's disease and other synucleinopathies.Expert opinion on therapeutic targets, , Volume: 16, Issue:4, 2012
α-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion.Neuroscience research, , Volume: 73, Issue:2, 2012
Parkinson's disease: gene therapies.Cold Spring Harbor perspectives in medicine, , Volume: 2, Issue:4, 2012
The role of autophagy in Parkinson's disease.Cold Spring Harbor perspectives in medicine, , Volume: 2, Issue:4, 2012
The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease.The Journal of experimental medicine, , Apr-09, Volume: 209, Issue:4, 2012
Development of electrochemiluminescence-based singleplex and multiplex assays for the quantification of α-synuclein and other proteins in cerebrospinal fluid.Methods (San Diego, Calif.), , Volume: 56, Issue:4, 2012
The molecular basis of dopaminergic brain imaging in Parkinson's disease.The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of..., , Volume: 56, Issue:1, 2012
Critical role of truncated α-synuclein and aggregates in Parkinson's disease and incidental Lewy body disease.Brain pathology (Zurich, Switzerland), , Volume: 22, Issue:6, 2012
Analysis of LRRK2, SNCA, Parkin, PINK1, and DJ-1 in Zambian patients with Parkinson's disease.Parkinsonism & related disorders, , Volume: 18, Issue:5, 2012
The SNCA (A53T, A30P, E46K) and LRRK2 (G2019S) mutations are rare cause of Parkinson's disease in South Indian patients.Parkinsonism & related disorders, , Volume: 18, Issue:6, 2012
Glucose regulated protein 78 diminishes α-synuclein neurotoxicity in a rat model of Parkinson disease.Molecular therapy : the journal of the American Society of Gene Therapy, , Volume: 20, Issue:7, 2012
The dietary supplementation of nordihydroguaiaretic acid (NDGA) delayed the loss of climbing ability in Drosophila model of Parkinson's disease.Journal of dietary supplements, , Volume: 9, Issue:1, 2012
SNCA polymorphisms, smoking, and sporadic Parkinson's disease in Japanese.Parkinsonism & related disorders, , Volume: 18, Issue:5, 2012
Partial trisomy 4q associated with young-onset dopa-responsive parkinsonism.Archives of neurology, , Volume: 69, Issue:3, 2012
Relationship between mitochondria and α-synuclein: a study of single substantia nigra neurons.Archives of neurology, , Volume: 69, Issue:3, 2012
Semisynthetic, site-specific ubiquitin modification of α-synuclein reveals differential effects on aggregation.Journal of the American Chemical Society, , Mar-28, Volume: 134, Issue:12, 2012
Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-07, Volume: 32, Issue:10, 2012
Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-07, Volume: 32, Issue:10, 2012
Increased expression of α-synuclein by SNCA duplication is associated with resistance to toxic stimuli.Journal of molecular neuroscience : MN, , Volume: 47, Issue:2, 2012
Exon dosage variations in Brazilian patients with Parkinson's disease: analysis of SNCA, PARKIN, PINK1 and DJ-1 genes.Disease markers, , Volume: 32, Issue:3, 2012
An antibody with high reactivity for disease-associated α-synuclein reveals extensive brain pathology.Acta neuropathologica, , Volume: 124, Issue:1, 2012
Phosphorylated α-synuclein as a potential biomarker for Parkinson's disease and related disorders.Expert review of molecular diagnostics, , Volume: 12, Issue:2, 2012
Adenosine A2A receptor gene disruption protects in an α-synuclein model of Parkinson's disease.Annals of neurology, , Volume: 71, Issue:2, 2012
α-Synuclein fate: proteasome or autophagy?Autophagy, , Volume: 8, Issue:3, 2012
Cognitive deficits in a mouse model of pre-manifest Parkinson's disease.The European journal of neuroscience, , Volume: 35, Issue:6, 2012
α-Synuclein in Parkinson's disease.Cold Spring Harbor perspectives in medicine, , Volume: 2, Issue:2, 2012
Excess α-synuclein worsens disease in mice lacking ubiquitin carboxy-terminal hydrolase L1.Scientific reports, , Volume: 2, 2012
Synaptic dysfunction in Parkinson's disease.Advances in experimental medicine and biology, , Volume: 970, 2012
A progressive mouse model of Parkinson's disease: the Thy1-aSyn ("Line 61") mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 9, Issue:2, 2012
SNP rs356219 of the α-synuclein (SNCA) gene is associated with Parkinson's disease in a Chinese Han population.Parkinsonism & related disorders, , Volume: 18, Issue:5, 2012
Phosphorylated α-synuclein in Parkinson's disease.Science translational medicine, , Feb-15, Volume: 4, Issue:121, 2012
Lewy-like aggregation of α-synuclein reduces protein phosphatase 2A activity in vitro and in vivo.Neuroscience, , Apr-05, Volume: 207, 2012
Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-08, Volume: 32, Issue:6, 2012
The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity.PLoS genetics, , Volume: 8, Issue:2, 2012
Brain banks as key part of biochemical and molecular studies on cerebral cortex involvement in Parkinson's disease.The FEBS journal, , Volume: 279, Issue:7, 2012
Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-01, Volume: 32, Issue:5, 2012
Alpha-synuclein's degradation in vivo: opening a new (cranial) window on the roles of degradation pathways in Parkinson disease.Autophagy, , Feb-01, Volume: 8, Issue:2, 2012
An evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology.Journal of neurology, neurosurgery, and psychiatry, , Volume: 83, Issue:4, 2012
Head injury, α-synuclein Rep1, and Parkinson's disease.Annals of neurology, , Volume: 71, Issue:1, 2012
No evidence for differential methylation of α-synuclein in leukocyte DNA of Parkinson's disease patients.Movement disorders : official journal of the Movement Disorder Society, , Volume: 27, Issue:4, 2012
Mechanisms of protein oligomerization: inhibitor of functional amyloids templates α-synuclein fibrillation.Journal of the American Chemical Society, , Feb-22, Volume: 134, Issue:7, 2012
Animal models of Parkinson's disease.The FEBS journal, , Volume: 279, Issue:7, 2012
Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation.The FEBS journal, , Volume: 279, Issue:6, 2012
MicroRNAs in Parkinson's disease.Neurobiology of disease, , Volume: 46, Issue:2, 2012
A DNA resequencing array for genes involved in Parkinson's disease.Parkinsonism & related disorders, , Volume: 18, Issue:4, 2012
Animal models of the non-motor features of Parkinson's disease.Neurobiology of disease, , Volume: 46, Issue:3, 2012
Phosphorylation of α-synuclein protein at Ser-129 reduces neuronal dysfunction by lowering its membrane binding property in Caenorhabditis elegans.The Journal of biological chemistry, , Mar-02, Volume: 287, Issue:10, 2012
Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway.Molecular neurodegeneration, , Jan-09, Volume: 7, 2012
Use of viral vectors to create animal models for Parkinson's disease.Neurobiology of disease, , Volume: 48, Issue:2, 2012
Fluoxetine rescues impaired hippocampal neurogenesis in a transgenic A53T synuclein mouse model.The European journal of neuroscience, , Volume: 35, Issue:1, 2012
Curcumin-glucoside, a novel synthetic derivative of curcumin, inhibits α-synuclein oligomer formation: relevance to Parkinson's disease.Current pharmaceutical design, , Volume: 18, Issue:1, 2012
Peculiarities of copper binding to alpha-synuclein.Journal of biomolecular structure & dynamics, , Volume: 29, Issue:4, 2012
Synaptic protein alterations in Parkinson's disease.Molecular neurobiology, , Volume: 45, Issue:1, 2012
Meta-analysis of genetic and environmental Parkinson's disease models reveals a common role of mitochondrial protection pathways.Neurobiology of disease, , Volume: 45, Issue:3, 2012
Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons.Neurobiology of disease, , Volume: 45, Issue:3, 2012
α-Synuclein potentiates interleukin-1β-induced CXCL10 expression in human A172 astrocytoma cells.Neuroscience letters, , Jan-24, Volume: 507, Issue:2, 2012
Molecular pathways in sporadic PD.Parkinsonism & related disorders, , Volume: 18 Suppl 1, 2012
Patterns of α-synuclein pathology in incidental cases and clinical subtypes of Parkinson's disease.Parkinsonism & related disorders, , Volume: 18 Suppl 1, 2012
Synucleinopathies from bench to bedside.Parkinsonism & related disorders, , Volume: 18 Suppl 1, 2012
Misfolded α-synuclein and Toll-like receptors: therapeutic targets for Parkinson's disease.Parkinsonism & related disorders, , Volume: 18 Suppl 1, 2012
Vaccination for Parkinson's disease.Parkinsonism & related disorders, , Volume: 18 Suppl 1, 2012
Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression.Molecular and cellular neurosciences, , Volume: 49, Issue:2, 2012
First neuropathological description of a patient with Parkinson's disease and LRRK2 p.N1437H mutation.Parkinsonism & related disorders, , Volume: 18, Issue:4, 2012
α-Synuclein synaptic pathology and its implications in the development of novel therapeutic approaches to cure Parkinson's disease.Brain research, , Jan-13, Volume: 1432, 2012
Molecular pathogenesis of Parkinson's disease: update.Journal of neurology, neurosurgery, and psychiatry, , Volume: 83, Issue:4, 2012
Characterization of heparin-induced glyceraldehyde-3-phosphate dehydrogenase early amyloid-like oligomers and their implication in α-synuclein aggregation.The Journal of biological chemistry, , Jan-20, Volume: 287, Issue:4, 2012
α-Synuclein modifies huntingtin aggregation in living cells.FEBS letters, , Jan-02, Volume: 586, Issue:1, 2012
SNCA triplication Parkinson's patient's iPSC-derived DA neurons accumulate α-synuclein and are susceptible to oxidative stress.PloS one, , Volume: 6, Issue:11, 2011
Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Nov-16, Volume: 31, Issue:46, 2011
Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes.Bioorganic & medicinal chemistry, , Dec-15, Volume: 19, Issue:24, 2011
Caenorhabditis elegans as an experimental tool for the study of complex neurological diseases: Parkinson's disease, Alzheimer's disease and autism spectrum disorder.Invertebrate neuroscience : IN, , Volume: 11, Issue:2, 2011
Distinct hydration properties of wild-type and familial point mutant A53T of α-synuclein associated with Parkinson's disease.Biophysical journal, , Nov-02, Volume: 101, Issue:9, 2011
Pathological looping in the synucleinopathies: investigating the link between Parkinson's disease and Gaucher disease.Disease models & mechanisms, , Volume: 4, Issue:6, 2011
Dynamic modeling of α-synuclein aggregation in dopaminergic neuronal system indicates points of neuroprotective intervention: experimental validation with implications for Parkinson's therapy.Neuroscience, , Dec-29, Volume: 199, 2011
Identification of allele-specific RNAi effectors targeting genetic forms of Parkinson's disease.PloS one, , Volume: 6, Issue:10, 2011
Genetic variants of α-synuclein are not associated with essential tremor.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:14, 2011
Identification of bilateral changes in TID1 expression in the 6-OHDA rat model of Parkinson's disease.PloS one, , Volume: 6, Issue:10, 2011
Pathological roles of α-synuclein in neurological disorders.The Lancet. Neurology, , Volume: 10, Issue:11, 2011
α-synuclein promotes neuroprotection through NF-κB-mediated transcriptional regulation of protein kinase Cδ.Science signaling, , Oct-18, Volume: 4, Issue:195, 2011
Convergence of miRNA expression profiling, α-synuclein interacton and GWAS in Parkinson's disease.PloS one, , Volume: 6, Issue:10, 2011
Dopamine and α-synuclein dysfunction in Smad3 null mice.Molecular neurodegeneration, , Oct-13, Volume: 6, 2011
The yin and yang of amyloid: insights from α-synuclein and repeat domain of Pmel17.Physical chemistry chemical physics : PCCP, , Dec-07, Volume: 13, Issue:45, 2011
[The effect of small ubiquitin-like modifier-1 modification on the formation of Lewy body-like inclusions in cytoplasm and apoptosis of HEK293 cell induced by overexpression and mutation of alpha-synuclein].Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, , Volume: 28, Issue:5, 2011
Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:12, 2011
Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway.Proceedings of the National Academy of Sciences of the United States of America, , Oct-11, Volume: 108, Issue:41, 2011
The oxysterol 27-hydroxycholesterol regulates α-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors--relevance to Parkinson's disease.Journal of neurochemistry, , Volume: 119, Issue:5, 2011
Aggresome formation and segregation of inclusions influence toxicity of α-synuclein and synphilin-1 in yeast.Biochemical Society transactions, , Volume: 39, Issue:5, 2011
Pre-fibrillar α-synuclein mutants cause Parkinson's disease-like non-motor symptoms in Drosophila.PloS one, , Volume: 6, Issue:9, 2011
Anti-Parkinsonian effects of Bacopa monnieri: insights from transgenic and pharmacological Caenorhabditis elegans models of Parkinson's disease.Biochemical and biophysical research communications, , Oct-07, Volume: 413, Issue:4, 2011
Modeling dopamine neuron degeneration in Caenorhabditis elegans.Methods in molecular biology (Clifton, N.J.), , Volume: 793, 2011
Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis.The American journal of pathology, , Volume: 179, Issue:5, 2011
Macroautophagy and the proteasome are differently involved in the degradation of alpha-synuclein wild type and mutated A30P in an in vitro inducible model (PC12/TetOn).Neuroscience, , Nov-10, Volume: 195, 2011
Parkinson's disease and α-synuclein expression.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:12, 2011
Initial neuropsychological impairments in patients with the E46K mutation of the α-synuclein gene (PARK 1).Journal of the neurological sciences, , Nov-15, Volume: 310, Issue:1-2, 2011
The Parkinson's disease protein LRRK2 impairs proteasome substrate clearance without affecting proteasome catalytic activity.Cell death & disease, , Aug-25, Volume: 2, 2011
Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells.The Journal of clinical investigation, , Volume: 121, Issue:9, 2011
Phosphorylated α-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 25, Issue:12, 2011
Circadian dysfunction in a mouse model of Parkinson's disease.Experimental neurology, , Volume: 232, Issue:1, 2011
Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus.Nature communications, , Aug-23, Volume: 2, 2011
Proteostasis and movement disorders: Parkinson's disease and amyotrophic lateral sclerosis.Cold Spring Harbor perspectives in biology, , Oct-01, Volume: 3, Issue:10, 2011
Kinases as targets for Parkinson's disease: from genetics to therapy.CNS & neurological disorders drug targets, , Sep-01, Volume: 10, Issue:6, 2011
Drug targets from genetics: α-synuclein.CNS & neurological disorders drug targets, , Sep-01, Volume: 10, Issue:6, 2011
Hsc70 protein interaction with soluble and fibrillar alpha-synuclein.The Journal of biological chemistry, , Oct-07, Volume: 286, Issue:40, 2011
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein.The Journal of biological chemistry, , Sep-30, Volume: 286, Issue:39, 2011
Do interactions between SNCA, MAPT, and LRRK2 genes contribute to Parkinson's disease susceptibility?Parkinsonism & related disorders, , Volume: 17, Issue:10, 2011
Measurement of proteasomal dysfunction in cell models of dopaminergic degeneration.Methods in molecular biology (Clifton, N.J.), , Volume: 758, 2011
Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease.Neurology, , Aug-02, Volume: 77, Issue:5, 2011
Genetic variability in SNCA and Parkinson's disease.Neurogenetics, , Volume: 12, Issue:4, 2011
Gelsolin co-occurs with Lewy bodies in vivo and accelerates α-synuclein aggregation in vitro.Biochemical and biophysical research communications, , Aug-19, Volume: 412, Issue:1, 2011
Enhanced autophagy from chronic toxicity of iron and mutant A53T α-synuclein: implications for neuronal cell death in Parkinson disease.The Journal of biological chemistry, , Sep-23, Volume: 286, Issue:38, 2011
Toward the discovery of effective polycyclic inhibitors of alpha-synuclein amyloid assembly.The Journal of biological chemistry, , Sep-16, Volume: 286, Issue:37, 2011
A BACwards glance at neurodegeneration: molecular insights into disease from LRRK2, SNCA and MAPT BAC-transgenic mice.Biochemical Society transactions, , Volume: 39, Issue:4, 2011
CSF α-synuclein, tau, and amyloid β in Parkinson's disease.The Lancet. Neurology, , Volume: 10, Issue:8, 2011
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations.Cell, , Jul-22, Volume: 146, Issue:2, 2011
A lysosomal lair for a pathogenic protein pair.Science translational medicine, , Jul-13, Volume: 3, Issue:91, 2011
The curious case of phenocopies in families with genetic Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Aug-15, Volume: 26, Issue:10, 2011
Can α-synuclein be targeted in novel therapies for Parkinson's disease?Expert review of neurotherapeutics, , Volume: 11, Issue:7, 2011
The A53T mutation is key in defining the differences in the aggregation kinetics of human and mouse α-synuclein.Journal of the American Chemical Society, , Aug-31, Volume: 133, Issue:34, 2011
Neuropathology underlying clinical variability in patients with synucleinopathies.Acta neuropathologica, , Volume: 122, Issue:2, 2011
Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease.Disease models & mechanisms, , Volume: 4, Issue:5, 2011
Structured regions of α-synuclein fibrils include the early-onset Parkinson's disease mutation sites.Journal of molecular biology, , Aug-26, Volume: 411, Issue:4, 2011
Disease-related and genetic correlates of psychotic symptoms in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:12, 2011
Rho GTPase regulation of α-synuclein and VMAT2: implications for pathogenesis of Parkinson's disease.Molecular and cellular neurosciences, , Volume: 48, Issue:1, 2011
Parkinson's disease-associated mutations in α-synuclein and UCH-L1 inhibit the unconventional secretion of UCH-L1.Neurochemistry international, , Volume: 59, Issue:2, 2011
Pros and cons of a prion-like pathogenesis in Parkinson's disease.BMC neurology, , Jun-20, Volume: 11, 2011
Familial Parkinson disease mutations influence α-synuclein assembly.Neurobiology of disease, , Volume: 43, Issue:3, 2011
Alpha- and beta-synuclein expression in Parkinson disease with and without dementia.Journal of the neurological sciences, , Nov-15, Volume: 310, Issue:1-2, 2011
Identification of novel α-synuclein isoforms in human brain tissue by using an online nanoLC-ESI-FTICR-MS method.Neurochemical research, , Volume: 36, Issue:11, 2011
Enzyme-linked immunosorbent assays for α-synuclein with species and multimeric state specificities.Journal of neuroscience methods, , Aug-15, Volume: 199, Issue:2, 2011
Neuroprotection of α-synuclein under acute and chronic rotenone and maneb treatment is abolished by its familial Parkinson's disease mutations A30P, A53T and E46K.Neurotoxicology, , Volume: 32, Issue:6, 2011
Clinical features, with video documentation, of the original familial lewy body parkinsonism caused by α-synuclein triplication (Iowa kindred).Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:11, 2011
Alpha-synuclein interacts with Glucocerebrosidase providing a molecular link between Parkinson and Gaucher diseases.The Journal of biological chemistry, , Aug-12, Volume: 286, Issue:32, 2011
Comparative analysis of different peptidyl-prolyl isomerases reveals FK506-binding protein 12 as the most potent enhancer of alpha-synuclein aggregation.The Journal of biological chemistry, , Jul-29, Volume: 286, Issue:30, 2011
Proteasome inhibition induces α-synuclein SUMOylation and aggregate formation.Journal of the neurological sciences, , Aug-15, Volume: 307, Issue:1-2, 2011
Stress, allostatic load, catecholamines, and other neurotransmitters in neurodegenerative diseases.Endocrine regulations, , Volume: 45, Issue:2, 2011
α-Synuclein expression selectively affects tumorigenesis in mice modeling Parkinson's disease.PloS one, , Volume: 6, Issue:5, 2011
Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?Brain : a journal of neurology, , Volume: 134, Issue:Pt 5, 2011
Synphilin suppresses α-synuclein neurotoxicity in a Parkinson's disease Drosophila model.Genesis (New York, N.Y. : 2000), , Volume: 49, Issue:5, 2011
A deadly spread: cellular mechanisms of α-synuclein transfer.Cell death and differentiation, , Volume: 18, Issue:9, 2011
Parkinson's disease with dementia, lewy-body disorders and alpha-synuclein: recent advances and a case report.Acta neurologica Taiwanica, , Volume: 20, Issue:1, 2011
Parkinson disease: PD biomarkers-use of α-synuclein reaches new levels.Nature reviews. Neurology, , May-10, Volume: 7, Issue:6, 2011
Expression of mutant alpha-synuclein modulates microglial phenotype in vitro.Journal of neuroinflammation, , May-09, Volume: 8, 2011
Increased dopaminergic cells and protein aggregates in the olfactory bulb of patients with neurodegenerative disorders.Acta neuropathologica, , Volume: 122, Issue:1, 2011
Parkinson's disease, cortical dysfunction, and alpha-synuclein.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:8, 2011
α-synuclein reactive antibodies as diagnostic biomarkers in blood sera of Parkinson's disease patients.PloS one, , Apr-25, Volume: 6, Issue:4, 2011
Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applications.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:8, 2011
ASICs mediate the modulatory effect by paeoniflorin on α-synuclein autophagic degradation.Brain research, , Jun-17, Volume: 1396, 2011
α-Synuclein-induced tubule formation in lipid bilayers.The journal of physical chemistry. B, , May-19, Volume: 115, Issue:19, 2011
Converging environmental and genetic pathways in the pathogenesis of Parkinson's disease.Journal of the neurological sciences, , Jul-15, Volume: 306, Issue:1-2, 2011
The hexapeptide PGVTAV suppresses neurotoxicity of human α-synuclein aggregates.Biochemical and biophysical research communications, , May-06, Volume: 408, Issue:2, 2011
Allostery in a disordered protein: oxidative modifications to α-synuclein act distally to regulate membrane binding.Journal of the American Chemical Society, , May-11, Volume: 133, Issue:18, 2011
Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein.The Journal of biological chemistry, , Jun-10, Volume: 286, Issue:23, 2011
Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α-synuclein.Journal of neuroscience research, , Volume: 89, Issue:7, 2011
Striatal β-amyloid in dementia with Lewy bodies but not Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 118, Issue:5, 2011
Direct interaction of α-synuclein and AKT regulates IGF-1 signaling: implication of Parkinson disease.Neuro-Signals, , Volume: 19, Issue:2, 2011
Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing.Annals of neurology, , Volume: 69, Issue:6, 2011
Cerebrospinal fluid Tau/α-synuclein ratio in Parkinson's disease and degenerative dementias.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:8, 2011
Increased expression of α-synuclein in aged human brain associated with neuromelanin accumulation.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 118, Issue:11, 2011
Hyperphosphorylated Tau in an α-synuclein-overexpressing transgenic model of Parkinson's disease.The European journal of neuroscience, , Volume: 33, Issue:9, 2011
Tauopathic changes in the striatum of A53T α-synuclein mutant mouse model of Parkinson's disease.PloS one, , Mar-21, Volume: 6, Issue:3, 2011
Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds.FEBS letters, , Apr-20, Volume: 585, Issue:8, 2011
Blockade of enzyme activity inhibits tissue transglutaminase-mediated transamidation of α-synuclein in a cellular model of Parkinson's disease.Neurochemistry international, , Volume: 58, Issue:7, 2011
Replication of MAPT and SNCA, but not PARK16-18, as susceptibility genes for Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 26, Issue:5, 2011
Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers.Experimental & molecular medicine, , Apr-30, Volume: 43, Issue:4, 2011
SNCA locus duplication carriers: from genetics to Parkinson disease phenotypes.Human mutation, , Volume: 32, Issue:4, 2011
Common variants in PARK loci and related genes and Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Feb-01, Volume: 26, Issue:2, 2011
Molecular chaperones and associated cellular clearance mechanisms against toxic protein conformers in Parkinson's disease.Neuro-degenerative diseases, , Volume: 8, Issue:6, 2011
Progressive neurodegeneration or endogenous compensation in an animal model of Parkinson's disease produced by decreasing doses of alpha-synuclein.PloS one, , Mar-07, Volume: 6, Issue:3, 2011
Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression.Annals of neurology, , Volume: 69, Issue:3, 2011
Changes in the solubility and phosphorylation of α-synuclein over the course of Parkinson's disease.Acta neuropathologica, , Volume: 121, Issue:6, 2011
Independent and joint effects of the MAPT and SNCA genes in Parkinson disease.Annals of neurology, , Volume: 69, Issue:5, 2011
Salivary α-synuclein and DJ-1: potential biomarkers for Parkinson's disease.Brain : a journal of neurology, , Volume: 134, Issue:Pt 7, 2011
Structures behind the amyloid aggregation of α-synuclein: an NMR based approach.Current protein & peptide science, , Volume: 12, Issue:3, 2011
A microRNA embedded AAV α-synuclein gene silencing vector for dopaminergic neurons.Brain research, , Apr-22, Volume: 1386, 2011
Residue-specific fluorescent probes of α-synuclein: detection of early events at the N- and C-termini during fibril assembly.Biochemistry, , Mar-29, Volume: 50, Issue:12, 2011
Specificity and kinetics of alpha-synuclein binding to model membranes determined with fluorescent excited state intramolecular proton transfer (ESIPT) probe.The Journal of biological chemistry, , Apr-15, Volume: 286, Issue:15, 2011
Role of matrix metalloproteinase 3-mediated alpha-synuclein cleavage in dopaminergic cell death.The Journal of biological chemistry, , Apr-22, Volume: 286, Issue:16, 2011
Redox activity of α-synuclein-Cu is silenced by Zn₇-metallothionein-3.Free radical biology & medicine, , Jun-01, Volume: 50, Issue:11, 2011
Coordination features and affinity of the Cu²+ site in the α-synuclein protein of Parkinson's disease.Biochemistry, , Mar-22, Volume: 50, Issue:11, 2011
α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study.The Lancet. Neurology, , Volume: 10, Issue:3, 2011
Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission.Neurobiology of disease, , Volume: 42, Issue:3, 2011
Low-resolution structure of a vesicle disrupting α-synuclein oligomer that accumulates during fibrillation.Proceedings of the National Academy of Sciences of the United States of America, , Feb-22, Volume: 108, Issue:8, 2011
From GWAS to clinical utility in Parkinson's disease.Lancet (London, England), , Feb-19, Volume: 377, Issue:9766, 2011
Copper(II) enhances membrane-bound α-synuclein helix formation.Metallomics : integrated biometal science, , Volume: 3, Issue:3, 2011
Decreased reuptake of dopamine in the dorsal striatum in the absence of α-synuclein.Brain research, , Mar-25, Volume: 1382, 2011
Defects in very long chain fatty acid synthesis enhance alpha-synuclein toxicity in a yeast model of Parkinson's disease.PloS one, , Jan-11, Volume: 6, Issue:1, 2011
Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study.Human molecular genetics, , Apr-15, Volume: 20, Issue:8, 2011
Mutant A53T alpha-synuclein induces neuronal death by increasing mitochondrial autophagy.The Journal of biological chemistry, , Mar-25, Volume: 286, Issue:12, 2011
Alpha-synuclein is a cellular ferrireductase.PloS one, , Jan-10, Volume: 6, Issue:1, 2011
Genome-wide association study confirms extant PD risk loci among the Dutch.European journal of human genetics : EJHG, , Volume: 19, Issue:6, 2011
α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells.The Journal of clinical investigation, , Volume: 121, Issue:2, 2011
Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease.Environmental health perspectives, , Volume: 119, Issue:6, 2011
Immunoprotection against toxic biomarkers is retained during Parkinson's disease progression.Journal of neuroimmunology, , Volume: 233, Issue:1-2, 2011
α-Synuclein, leucine-rich repeat kinase-2, and manganese in the pathogenesis of Parkinson disease.Neurotoxicology, , Volume: 32, Issue:5, 2011
Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism.Pharmacological research, , Volume: 63, Issue:5, 2011
The role of the C-terminus of human α-synuclein: intra-disulfide bonds between the C-terminus and other regions stabilize non-fibrillar monomeric isomers.FEBS letters, , Feb-04, Volume: 585, Issue:3, 2011
Interaction of prolyl oligopeptidase with α-synuclein.CNS & neurological disorders drug targets, , Volume: 10, Issue:3, 2011
A new perspective in Parkinson's disease, chaperone-mediated autophagy.Parkinsonism & related disorders, , Volume: 17, Issue:4, 2011
The role of His-50 of α-synuclein in binding Cu(II): pH dependence, speciation, thermodynamics and structure.Metallomics : integrated biometal science, , Volume: 3, Issue:3, 2011
Caenorhabditis elegans as a model system for identifying effectors of α-synuclein misfolding and dopaminergic cell death associated with Parkinson's disease.Methods (San Diego, Calif.), , Volume: 53, Issue:3, 2011
A pilot trial of the microtubule-interacting peptide (NAP) in mice overexpressing alpha-synuclein shows improvement in motor function and reduction of alpha-synuclein inclusions.Molecular and cellular neurosciences, , Volume: 46, Issue:3, 2011
Induction of the unfolded protein response by α-synuclein in experimental models of Parkinson's disease.Journal of neurochemistry, , Volume: 116, Issue:4, 2011
Assays for α-synuclein aggregation.Methods (San Diego, Calif.), , Volume: 53, Issue:3, 2011
SNCA, MAPT, and GSK3B in Parkinson disease: a gene-gene interaction study.European journal of neurology, , Volume: 18, Issue:6, 2011
The Parkinson disease protein α-synuclein inhibits autophagy.Autophagy, , Volume: 7, Issue:4, 2011
Towards elucidation of the role of ubiquitination in the pathogenesis of Parkinson's disease with semisynthetic ubiquitinated α-synuclein.Angewandte Chemie (International ed. in English), , Jan-10, Volume: 50, Issue:2, 2011
Raised calcium promotes α-synuclein aggregate formation.Molecular and cellular neurosciences, , Volume: 46, Issue:2, 2011
Segmental conformational disorder and dynamics in the intrinsically disordered protein α-synuclein and its chain length dependence.Journal of molecular biology, , Feb-04, Volume: 405, Issue:5, 2011
Hallucinations and REM sleep behaviour disorder in Parkinson's disease: dream imagery intrusions and other hypotheses.Consciousness and cognition, , Volume: 20, Issue:4, 2011
Replication of GWAS associations for GAK and MAPT in Parkinson's disease.Annals of human genetics, , Volume: 75, Issue:2, 2011
Inducible dopaminergic glutathione depletion in an α-synuclein transgenic mouse model results in age-related olfactory dysfunction.Neuroscience, , Jan-13, Volume: 172, 2011
Lack of interaction of SNCA and MAPT genotypes in Parkinson's disease.European journal of neurology, , Volume: 18, Issue:3, 2011
The effect of SNCA 3' region on the levels of SNCA-112 splicing variant.Neurogenetics, , Volume: 12, Issue:1, 2011
Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21.Human molecular genetics, , Jan-15, Volume: 20, Issue:2, 2011
CD3 in Lewy pathology: does the abnormal recall of neurodevelopmental processes underlie Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 118, Issue:1, 2011
Synaptic dysfunction in genetic models of Parkinson's disease: a role for autophagy?Neurobiology of disease, , Volume: 43, Issue:1, 2011
Apoptosis in Parkinson's disease: is p53 the missing link between genetic and sporadic Parkinsonism?Cellular signalling, , Volume: 23, Issue:6, 2011
Aberrant protein structure and diseases of the brain.Irish journal of medical science, , Volume: 180, Issue:1, 2011
Postural instability/gait disturbance in Parkinson's disease has distinct subtypes: an exploratory analysis.Journal of neurology, neurosurgery, and psychiatry, , Volume: 82, Issue:5, 2011
Neuropathology of sporadic Parkinson disease before the appearance of parkinsonism: preclinical Parkinson disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 118, Issue:5, 2011
α-synuclein aggregation reduces nigral myocyte enhancer factor-2D in idiopathic and experimental Parkinson's disease.Neurobiology of disease, , Volume: 41, Issue:1, 2011
Presence of tissue transglutaminase in granular endoplasmic reticulum is characteristic of melanized neurons in Parkinson's disease brain.Brain pathology (Zurich, Switzerland), , Volume: 21, Issue:2, 2011
Phosphorylation of α-synuclein upregulates tyrosine hydroxylase activity in MN9D cells.Acta histochemica, , Volume: 113, Issue:1, 2011
Incidental Lewy body disease: do some cases represent a preclinical stage of dementia with Lewy bodies?Neurobiology of aging, , Volume: 32, Issue:5, 2011
Cardiovascular autonomic dysfunction in animal models of Parkinson's disease.Journal of Parkinson's disease, , Volume: 1, Issue:4, 2011
Mitochondrial dysfunction in skin fibroblasts from a Parkinson's disease patient with an alpha-synuclein triplication.Journal of Parkinson's disease, , Volume: 1, Issue:2, 2011
Mouse models of cognitive deficits due to alpha-synuclein pathology.Journal of Parkinson's disease, , Volume: 1, Issue:3, 2011
Interaction between α-synuclein and tau genotypes and the progression of Parkinson's disease.Journal of Parkinson's disease, , Volume: 1, Issue:3, 2011
Disentangling the relationship between lewy bodies and nigral neuronal loss in Parkinson's disease.Journal of Parkinson's disease, , Volume: 1, Issue:3, 2011
Rab1A over-expression prevents Golgi apparatus fragmentation and partially corrects motor deficits in an alpha-synuclein based rat model of Parkinson's disease.Journal of Parkinson's disease, , Volume: 1, Issue:4, 2011
Colonic neuropathology is independent of olfactory dysfunction in Parkinson's disease.Journal of Parkinson's disease, , Volume: 1, Issue:4, 2011
Phosphorylation of α-Synuclein at Y125 and S129 alters its metal binding properties: implications for understanding the role of α-Synuclein in the pathogenesis of Parkinson's Disease and related disorders.ACS chemical neuroscience, , Nov-16, Volume: 2, Issue:11, 2011
Mechanism of copper(II)-induced misfolding of Parkinson's disease protein.Scientific reports, , Volume: 1, 2011
[Neuropathology].Rinsho shinkeigaku = Clinical neurology, , Volume: 51, Issue:11, 2011
Reduced content of α-synuclein in peripheral blood leukocytes of patients with LRRK2-associated Parkinson's disease.Bulletin of experimental biology and medicine, , Volume: 150, Issue:6, 2011
Tau reduction does not prevent motor deficits in two mouse models of Parkinson's disease.PloS one, , Volume: 6, Issue:12, 2011
Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein alpha-synuclein as revealed by ion mobility mass spectrometry.Chembiochem : a European journal of chemical biology, , Dec-16, Volume: 12, Issue:18, 2011
[Role of genetics in the etiology of synucleinopathies].Revista espanola de geriatria y gerontologia, , Volume: 46 Suppl 1, 2011
[Pathologic substrate of synucleinopathies. Introduction].Revista espanola de geriatria y gerontologia, , Volume: 46 Suppl 1, 2011
Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease.PloS one, , Volume: 6, Issue:12, 2011
The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation.Journal of neuroinflammation, , Nov-28, Volume: 8, 2011
[Update on the pathophysiology of Parkinson' disease].Bulletin de l'Academie nationale de medecine, , Volume: 194, Issue:7, 2010
[Gene for sporadic Parkinson's disease: common disease-common variants].Rinsho shinkeigaku = Clinical neurology, , Volume: 50, Issue:11, 2010
[Molecular genetics of familial Parkinson's disease].Rinsho shinkeigaku = Clinical neurology, , Volume: 50, Issue:11, 2010
[Progress in alpha-synuclein modifications and Parkinson's disease].Sheng li ke xue jin zhan [Progress in physiology], , Volume: 41, Issue:5, 2010
Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease.Cell death & disease, , Volume: 1, 2010
α-Synuclein and DJ-1 as potential biological fluid biomarkers for Parkinson's Disease.International journal of molecular sciences, , Oct-29, Volume: 11, Issue:11, 2010
CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease.PloS one, , Nov-24, Volume: 5, Issue:11, 2010
CSF from Parkinson disease patients differentially affects cultured microglia and astrocytes.BMC neuroscience, , Nov-29, Volume: 11, 2010
Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity.PloS one, , Nov-16, Volume: 5, Issue:11, 2010
A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death.Neurobiology of aging, , Volume: 31, Issue:1, 2010
The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease.Nature reviews. Neuroscience, , Volume: 11, Issue:12, 2010
Inhibiting α-synuclein oligomerization by stable cell-penetrating β-synuclein fragments recovers phenotype of Parkinson's disease model flies.PloS one, , Nov-10, Volume: 5, Issue:11, 2010
SNCA variant associated with Parkinson disease and plasma alpha-synuclein level.Archives of neurology, , Volume: 67, Issue:11, 2010
Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and Parkinson's disease-linked mutants.PloS one, , Oct-26, Volume: 5, Issue:10, 2010
Single molecule characterization of α-synuclein in aggregation-prone states.Biophysical journal, , Nov-03, Volume: 99, Issue:9, 2010
Synergistic effects of environmental risk factors and gene mutations in Parkinson's disease accelerate age-related neurodegeneration.Journal of neurochemistry, , Volume: 115, Issue:6, 2010
A photoelectrochemical immunosensor based on Au-doped TiO2 nanotube arrays for the detection of α-synuclein.Chemistry (Weinheim an der Bergstrasse, Germany), , Dec-27, Volume: 16, Issue:48, 2010
Proteomic analysis of dopamine and α-synuclein interplay in a cellular model of Parkinson's disease pathogenesis.The FEBS journal, , Volume: 277, Issue:23, 2010
αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction.Proceedings of the National Academy of Sciences of the United States of America, , Nov-09, Volume: 107, Issue:45, 2010
Bioinorganic chemistry of Parkinson's disease: structural determinants for the copper-mediated amyloid formation of alpha-synuclein.Inorganic chemistry, , Nov-15, Volume: 49, Issue:22, 2010
Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease.Neurology, , Nov-16, Volume: 75, Issue:20, 2010
CSF α-synuclein as a diagnostic biomarker for Parkinson disease and related dementias.Neurology, , Nov-16, Volume: 75, Issue:20, 2010
α-Synuclein and dopamine at the crossroads of Parkinson's disease.Trends in neurosciences, , Volume: 33, Issue:12, 2010
Phosphorylated alpha-synuclein at Ser-129 is targeted to the proteasome pathway in a ubiquitin-independent manner.The Journal of biological chemistry, , Dec-24, Volume: 285, Issue:52, 2010
Genetic analysis of pathways to Parkinson disease.Neuron, , Oct-21, Volume: 68, Issue:2, 2010
Identification of a helical intermediate in trifluoroethanol-induced alpha-synuclein aggregation.Proceedings of the National Academy of Sciences of the United States of America, , Nov-02, Volume: 107, Issue:44, 2010
Biomarkers in Parkinson's disease: a funder's perspective.Biomarkers in medicine, , Volume: 4, Issue:5, 2010
Quantification of α-synuclein in cerebrospinal fluid as a biomarker candidate: review of the literature and considerations for future studies.Biomarkers in medicine, , Volume: 4, Issue:5, 2010
Problems associated with fluid biomarkers for Parkinson's disease.Biomarkers in medicine, , Volume: 4, Issue:5, 2010
The genetics of Parkinson disease.Journal of geriatric psychiatry and neurology, , Volume: 23, Issue:4, 2010
PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease.Science translational medicine, , Oct-06, Volume: 2, Issue:52, 2010
Effects of curvature and composition on α-synuclein binding to lipid vesicles.Biophysical journal, , Oct-06, Volume: 99, Issue:7, 2010
Amyloid imaging of Lewy body-associated disorders.Movement disorders : official journal of the Movement Disorder Society, , Nov-15, Volume: 25, Issue:15, 2010
Effects of pH and temperature on the structural and thermodynamic character of alpha-syn12 peptide in aqueous solution.Journal of biomolecular structure & dynamics, , Volume: 28, Issue:3, 2010
Viral vector-mediated overexpression of α-synuclein as a progressive model of Parkinson's disease.Progress in brain research, , Volume: 184, 2010
Genetic mouse models of Parkinson's disease The state of the art.Progress in brain research, , Volume: 184, 2010
Mitochondrial α-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo.Neuroscience letters, , Dec-17, Volume: 486, Issue:3, 2010
α-Synuclein impairs macroautophagy: implications for Parkinson's disease.The Journal of cell biology, , Sep-20, Volume: 190, Issue:6, 2010
Distribution of cerebral amyloid deposition and its relevance to clinical phenotype in Lewy body dementia.Neuroscience letters, , Dec-03, Volume: 486, Issue:1, 2010
Stable alpha-synuclein oligomers strongly inhibit chaperone activity of the Hsp70 system by weak interactions with J-domain co-chaperones.The Journal of biological chemistry, , Dec-03, Volume: 285, Issue:49, 2010
Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.The EMBO journal, , Oct-20, Volume: 29, Issue:20, 2010
Glucocerebrosidase is present in α-synuclein inclusions in Lewy body disorders.Acta neuropathologica, , Volume: 120, Issue:5, 2010
Polyamine pathway contributes to the pathogenesis of Parkinson disease.Proceedings of the National Academy of Sciences of the United States of America, , Sep-28, Volume: 107, Issue:39, 2010
Human beta-synuclein rendered fibrillogenic by designed mutations.The Journal of biological chemistry, , Dec-03, Volume: 285, Issue:49, 2010
Being too inclusive about synuclein inclusions.Nature medicine, , Volume: 16, Issue:9, 2010
Brain stem pathology in Parkinson's disease: an evaluation of the Braak staging model.Movement disorders : official journal of the Movement Disorder Society, , Nov-15, Volume: 25, Issue:15, 2010
Clinical course of the first Asian family with Parkinsonism related to SNCA triplication.Movement disorders : official journal of the Movement Disorder Society, , Dec-15, Volume: 25, Issue:16, 2010
Oral N-acetyl-cysteine attenuates loss of dopaminergic terminals in alpha-synuclein overexpressing mice.PloS one, , Aug-23, Volume: 5, Issue:8, 2010
Amyloid formation and disaggregation of α-synuclein and its tandem repeat (α-TR).Biochemical and biophysical research communications, , Oct-01, Volume: 400, Issue:4, 2010
Secrets of the shaking palsy.Nature, , Aug-26, Volume: 466, Issue:7310, 2010
{alpha}-Synuclein gene duplication impairs reward learning.Proceedings of the National Academy of Sciences of the United States of America, , Sep-07, Volume: 107, Issue:36, 2010
Probing the micelle-bound aggregation-prone state of α-synuclein with (19)F NMR spectroscopy.Chembiochem : a European journal of chemical biology, , Sep-24, Volume: 11, Issue:14, 2010
Impaired sense of smell and color discrimination in monogenic and idiopathic Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Nov-15, Volume: 25, Issue:15, 2010
Alpha-synuclein in alpha-helical conformation at air-water interface: implication of conformation and orientation changes during its accumulation/aggregation.Chemical communications (Cambridge, England), , Sep-28, Volume: 46, Issue:36, 2010
[Function study advances of Parkinson disease related genes].Yi chuan = Hereditas, , Volume: 32, Issue:8, 2010
Redox reactions of the α-synuclein-Cu(2+) complex and their effects on neuronal cell viability.Biochemistry, , Sep-21, Volume: 49, Issue:37, 2010
Analysis of GWAS-linked loci in Parkinson disease reaffirms PARK16 as a susceptibility locus.Neurology, , Aug-10, Volume: 75, Issue:6, 2010
Chaperone-mediated autophagy markers in Parkinson disease brains.Archives of neurology, , Volume: 67, Issue:12, 2010
Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies.Progress in brain research, , Volume: 183, 2010
The impact of genetic research on our understanding of Parkinson's disease.Progress in brain research, , Volume: 183, 2010
Unravelling the role of defective genes.Progress in brain research, , Volume: 183, 2010
Neuroimaging for Lewy body disease: is the in vivo molecular imaging of α-synuclein neuropathology required and feasible?Brain research reviews, , Oct-05, Volume: 65, Issue:1, 2010
Tau protein: relevance to Parkinson's disease.The international journal of biochemistry & cell biology, , Volume: 42, Issue:11, 2010
New insights into the role of mitochondrial dysfunction and protein aggregation in Parkinson's disease.Biochimica et biophysica acta, , Volume: 1802, Issue:11, 2010
REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century.Neurology, , Aug-10, Volume: 75, Issue:6, 2010
α-Synuclein gene may interact with environmental factors in increasing risk of Parkinson's disease.Neuroepidemiology, , Volume: 35, Issue:3, 2010
Sensitive and specific detection of α-synuclein in human plasma.Journal of neuroscience research, , Volume: 88, Issue:12, 2010
Parkinson disease: Progress towards a molecular biomarker for Parkinson disease.Nature reviews. Neurology, , Volume: 6, Issue:7, 2010
TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains.Human molecular genetics, , Oct-01, Volume: 19, Issue:19, 2010
N(ɛ)-(carboxymethyl)lysine linkage to α-synuclein and involvement of advanced glycation end products in α-synuclein deposits in an MPTP-intoxicated mouse model.Biochimie, , Volume: 92, Issue:10, 2010
Neuroscience and heart-brain medicine: the year in review.Cleveland Clinic journal of medicine, , Volume: 77 Suppl 3, 2010
Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia.Experimental neurology, , Volume: 225, Issue:1, 2010
85-year old man with Parkinson's disease accompanying dementia.Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 62, Issue:6, 2010
The lipid-binding domain of wild type and mutant alpha-synuclein: compactness and interconversion between the broken and extended helix forms.The Journal of biological chemistry, , Sep-03, Volume: 285, Issue:36, 2010
Alpha-synuclein, lipids and Parkinson's disease.Progress in lipid research, , Volume: 49, Issue:4, 2010
Staging of alpha-synuclein in the olfactory bulb in a model of Parkinson's disease: cell types involved.Movement disorders : official journal of the Movement Disorder Society, , Aug-15, Volume: 25, Issue:11, 2010
The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia.Acta neuropathologica, , Volume: 120, Issue:2, 2010
Caspase-cleaved transactivation response DNA-binding protein 43 in Parkinson's disease and dementia with Lewy bodies.Neuro-degenerative diseases, , Volume: 7, Issue:4, 2010
Alteration of the alpha-synuclein folding landscape by a mutation related to Parkinson's disease.Angewandte Chemie (International ed. in English), , May-03, Volume: 49, Issue:20, 2010
Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease.Neuroscience letters, , Aug-09, Volume: 480, Issue:1, 2010
SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease.Brain : a journal of neurology, , Volume: 133, Issue:Pt 7, 2010
Parkinson disease: Parkinson disease-moving beyond association.Nature reviews. Neurology, , Volume: 6, Issue:6, 2010
Engineered disulfide bonds restore chaperone-like function of DJ-1 mutants linked to familial Parkinson's disease.Biochemistry, , Jul-13, Volume: 49, Issue:27, 2010
The role of phosphorylation in synucleinopathies: focus on Parkinson's disease.CNS & neurological disorders drug targets, , Volume: 9, Issue:4, 2010
alpha-Synuclein- and MPTP-generated rodent models of Parkinson's disease and the study of extracellular striatal dopamine dynamics: a microdialysis approach.CNS & neurological disorders drug targets, , Volume: 9, Issue:4, 2010
SNP rs7684318 of the alpha-synuclein gene is associated with Parkinson's disease in the Han Chinese population.Brain research, , Jul-30, Volume: 1346, 2010
[GSK-3beta: a central kinase for neurodegenerative diseases?].Medecine sciences : M/S, , Volume: 26, Issue:5, 2010
Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update.Human mutation, , Volume: 31, Issue:7, 2010
α-Synuclein: membrane interactions and toxicity in Parkinson's disease.Annual review of cell and developmental biology, , Volume: 26, 2010
Lack of replication of a previously reported association between polymorphism in the 3'UTR of the alpha-synuclein gene and Parkinson's disease in Chinese subjects.Neuroscience letters, , Jul-19, Volume: 479, Issue:1, 2010
Parkinson's disease-related protein, alpha-synuclein, in malignant melanoma.PloS one, , May-05, Volume: 5, Issue:5, 2010
Regulation of Weibel-Palade body exocytosis by alpha-synuclein in endothelial cells.The Journal of biological chemistry, , Jul-09, Volume: 285, Issue:28, 2010
Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains.The Journal of neuroscience : the official journal of the Society for Neuroscience, , May-05, Volume: 30, Issue:18, 2010
Drosophila histone deacetylase 6 protects dopaminergic neurons against {alpha}-synuclein toxicity by promoting inclusion formation.Molecular biology of the cell, , Jul-01, Volume: 21, Issue:13, 2010
Cardiac sympathetic denervation precedes nigrostriatal loss in the E46K mutation of the alpha-synuclein gene (SNCA).Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 20, Issue:4, 2010
Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson's disease cell model.BMC neuroscience, , Apr-30, Volume: 11, 2010
Membrane interactions of oligomeric alpha-synuclein: potential role in Parkinson's disease.Current protein & peptide science, , Volume: 11, Issue:5, 2010
Perivascular nerve fiber α-synuclein regulates contractility of mouse aorta: a link to autonomic dysfunction in Parkinson's disease.Neurochemistry international, , Volume: 56, Issue:8, 2010
Combined R-alpha-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease.Journal of cellular and molecular medicine, , Volume: 14, Issue:1-2, 2010
Mitochondrial pathobiology in Parkinson's disease and amyotrophic lateral sclerosis.Journal of Alzheimer's disease : JAD, , Volume: 20 Suppl 2, 2010
Astrocytic expression of Parkinson's disease-related A53T alpha-synuclein causes neurodegeneration in mice.Molecular brain, , Apr-21, Volume: 3, 2010
Extracellular neurosin degrades α-synuclein in cultured cells.Neuroscience research, , Volume: 67, Issue:4, 2010
Alpha-synuclein nitration and autophagy response are induced in peripheral blood cells from patients with Parkinson disease.Neuroscience letters, , Jun-14, Volume: 477, Issue:1, 2010
Nitrated alpha-synuclein induces the loss of dopaminergic neurons in the substantia nigra of rats.PloS one, , Apr-08, Volume: 5, Issue:4, 2010
alpha-Synucleinopathy in the human olfactory system in Parkinson's disease: involvement of calcium-binding protein- and substance P-positive cells.Acta neuropathologica, , Volume: 119, Issue:6, 2010
The HSP70 molecular chaperone is not beneficial in a mouse model of alpha-synucleinopathy.PloS one, , Apr-02, Volume: 5, Issue:4, 2010
Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo.The Journal of biological chemistry, , Jun-04, Volume: 285, Issue:23, 2010
Allelic imbalance of expression and epigenetic regulation within the alpha-synuclein wild-type and p.Ala53Thr alleles in Parkinson disease.Human mutation, , Volume: 31, Issue:6, 2010
Biomarkers: Parkinson disease with dementia and dementia with Lewy bodies.Parkinsonism & related disorders, , Volume: 16, Issue:5, 2010
Alpha-synuclein overexpression increases dopamine toxicity in BE2-M17 cells.BMC neuroscience, , Mar-25, Volume: 11, 2010
Differential effects of wild-type and A53T mutant isoform of alpha-synuclein on the mitochondrial proteome of differentiated SH-SY5Y cells.Journal of proteome research, , May-07, Volume: 9, Issue:5, 2010
The structure of dopamine induced alpha-synuclein oligomers.European biophysics journal : EBJ, , Volume: 39, Issue:10, 2010
Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders.Acta neuropathologica, , Volume: 119, Issue:6, 2010
Involvement of the cerebral cortex in Parkinson disease linked with G2019S LRRK2 mutation without cognitive impairment.Acta neuropathologica, , Volume: 120, Issue:2, 2010
Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease.Acta neuropathologica, , Volume: 119, Issue:6, 2010
Alpha-synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: implications in Parkinson's disease.FEBS letters, , Apr-16, Volume: 584, Issue:8, 2010
Dopamine quinones interact with alpha-synuclein to form unstructured adducts.Biochemical and biophysical research communications, , Apr-02, Volume: 394, Issue:2, 2010
Two Parkinson's disease patients with alpha-synuclein gene duplication and rapid cognitive decline.Movement disorders : official journal of the Movement Disorder Society, , May-15, Volume: 25, Issue:7, 2010
The regulatory role of α-synuclein and parkin in neuronal cell apoptosis; possible implications for the pathogenesis of Parkinson's disease.Apoptosis : an international journal on programmed cell death, , Volume: 15, Issue:11, 2010
Oligomeric alpha-synuclein and its role in neuronal death.IUBMB life, , Volume: 62, Issue:5, 2010
Distinct region-specific alpha-synuclein oligomers in A53T transgenic mice: implications for neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-03, Volume: 30, Issue:9, 2010
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-03, Volume: 30, Issue:9, 2010
Lysosomal degradation of alpha-synuclein in vivo.The Journal of biological chemistry, , Apr-30, Volume: 285, Issue:18, 2010
Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Jun-15, Volume: 25, Issue:8, 2010
Protein degradation, aggregation, and misfolding.Movement disorders : official journal of the Movement Disorder Society, , Volume: 25 Suppl 1, 2010
Clinical implications of gene discovery in Parkinson's disease and parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Volume: 25 Suppl 1, 2010
The behavior of alpha-synuclein in neurons.Movement disorders : official journal of the Movement Disorder Society, , Volume: 25 Suppl 1, 2010
Clues to how alpha-synuclein damages neurons in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 25 Suppl 1, 2010
Evidence in favor of Braak staging of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 25 Suppl 1, 2010
Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model.Human molecular genetics, , Jun-01, Volume: 19, Issue:11, 2010
Dysregulation of autophagy and Parkinson's disease: the MEF2D link.Apoptosis : an international journal on programmed cell death, , Volume: 15, Issue:11, 2010
Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-17, Volume: 30, Issue:7, 2010
Pure autonomic failure: a restricted Lewy body synucleinopathy or early Parkinson disease?Neurology, , Feb-16, Volume: 74, Issue:7, 2010
DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease.Brain : a journal of neurology, , Volume: 133, Issue:Pt 3, 2010
Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis.Neuron, , Jan-14, Volume: 65, Issue:1, 2010
alpha-Synuclein at the synaptic gate.Neuron, , Jan-14, Volume: 65, Issue:1, 2010
Strategies to increase the reproducibility of protein fibrillization in plate reader assays.Analytical biochemistry, , May-15, Volume: 400, Issue:2, 2010
Accelerated formation of alpha-synuclein oligomers by concerted action of the 20S proteasome and familial Parkinson mutations.Journal of bioenergetics and biomembranes, , Volume: 42, Issue:1, 2010
The progression of pathology in Parkinson's disease.Annals of the New York Academy of Sciences, , Volume: 1184, 2010
In silico evidence for glutathione- and iron-related pathogeneses in Parkinson's disease.Journal of neuroscience methods, , Apr-30, Volume: 188, Issue:1, 2010
Altered ion channel formation by the Parkinson's-disease-linked E46K mutant of alpha-synuclein is corrected by GM3 but not by GM1 gangliosides.Journal of molecular biology, , Mar-19, Volume: 397, Issue:1, 2010
Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153.The Journal of biological chemistry, , Apr-23, Volume: 285, Issue:17, 2010
Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes.Human molecular genetics, , May-01, Volume: 19, Issue:9, 2010
Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease.PloS one, , Jan-20, Volume: 5, Issue:1, 2010
DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity.Human molecular genetics, , Apr-15, Volume: 19, Issue:8, 2010
TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in the brain of Parkinson's disease and dementia with Lewy bodies.Neurobiology of disease, , Volume: 38, Issue:2, 2010
Neurodegenerative dementia and parkinsonism.The journal of nutrition, health & aging, , Volume: 14, Issue:1, 2010
Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway.Cellular signalling, , Volume: 22, Issue:5, 2010
Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.Annals of human genetics, , Volume: 74, Issue:2, 2010
Plasma alpha-synuclein in patients with Parkinson's disease with and without treatment.Movement disorders : official journal of the Movement Disorder Society, , Mar-15, Volume: 25, Issue:4, 2010
DnaK/DnaJ/GrpE of Hsp70 system have differing effects on alpha-synuclein fibrillation involved in Parkinson's disease.International journal of biological macromolecules, , Mar-01, Volume: 46, Issue:2, 2010
Ageing, neurodegeneration and Parkinson's disease.Age and ageing, , Volume: 39, Issue:2, 2010
Genetic basis of Parkinson disease.Neurosurgical focus, , Volume: 28, Issue:1, 2010
Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopy.Biochemistry, , Feb-09, Volume: 49, Issue:5, 2010
In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia.Neurology, , Jan-05, Volume: 74, Issue:1, 2010
DNA induced folding/fibrillation of alpha-synuclein: new insights in Parkinson's disease.Frontiers in bioscience (Landmark edition), , 01-01, Volume: 15, Issue:2, 2010
Pathogenesis of Parkinson's disease: emerging role of molecular chaperones.Trends in molecular medicine, , Volume: 16, Issue:1, 2010
Dysfunctional mitochondria uphold calpain activation: contribution to Parkinson's disease pathology.Neurobiology of disease, , Volume: 37, Issue:3, 2010
Clinical availability of skin biopsy in the diagnosis of Parkinson's disease.Neuroscience letters, , Jan-29, Volume: 469, Issue:3, 2010
Yeast unfolds the road map toward alpha-synuclein-induced cell death.Cell death and differentiation, , Volume: 17, Issue:5, 2010
Analysis of exon dosage using MLPA in South African Parkinson's disease patients.Neurogenetics, , Volume: 11, Issue:3, 2010
Binding of alpha-synuclein with Fe(III) and with Fe(II) and biological implications of the resultant complexes.Journal of inorganic biochemistry, , Volume: 104, Issue:4, 2010
Lovastatin ameliorates alpha-synuclein accumulation and oxidation in transgenic mouse models of alpha-synucleinopathies.Experimental neurology, , Volume: 221, Issue:2, 2010
Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation.Brain : a journal of neurology, , Volume: 133, Issue:Pt 1, 2010
Letter to the editor on "Threonine 53 in alpha-synuclein is conserved in long-living non-primate animals".Biochemical and biophysical research communications, , Jan-01, Volume: 391, Issue:1, 2010
Dopamine facilitates alpha-synuclein oligomerization in human neuroblastoma SH-SY5Y cells.Biochemical and biophysical research communications, , Jan-01, Volume: 391, Issue:1, 2010
Curcumin exposure induces expression of the Parkinson's disease-associated leucine-rich repeat kinase 2 (LRRK2) in rat mesencephalic cells.Neuroscience letters, , Jan-04, Volume: 468, Issue:2, 2010
Recurrent systemic infections with Streptococcus pneumoniae do not aggravate the course of experimental neurodegenerative diseases.Journal of neuroscience research, , Volume: 88, Issue:5, 2010
Oxidants induce alternative splicing of alpha-synuclein: Implications for Parkinson's disease.Free radical biology & medicine, , Feb-01, Volume: 48, Issue:3, 2010
Lymphomonocyte alpha-synuclein levels in aging and in Parkinson disease.Neurobiology of aging, , Volume: 31, Issue:5, 2010
G protein-coupled receptor kinase 5, overexpressed in the alpha-synuclein up-regulation model of Parkinson's disease, regulates bcl-2 expression.Brain research, , Jan-11, Volume: 1307, 2010
VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease.Neurobiology of disease, , Volume: 37, Issue:2, 2010
Establishment of stably transfected rat neuronal cell lines expressing alpha-synuclein GFP fusion proteins.Journal of molecular neuroscience : MN, , Volume: 41, Issue:1, 2010
Hsp70 molecular chaperones and Parkinson's disease.Biopolymers, , Volume: 93, Issue:3, 2010
Structure and function of the molecular chaperone Hsp104 from yeast.Biopolymers, , Volume: 93, Issue:3, 2010
Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein: mechanistic insights and pathological implication.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 24, Issue:1, 2010
Are genetic and sporadic Parkinson's disease patients equally susceptible to develop dementia?Journal of the neurological sciences, , Feb-15, Volume: 289, Issue:1-2, 2010
A comparative study of LRRK2, PINK1 and genetically undefined familial Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry, , Volume: 81, Issue:4, 2010
Genome-wide microarray analysis of the differential neuroprotective effects of antioxidants in neuroblastoma cells overexpressing the familial Parkinson's disease alpha-synuclein A53T mutation.Neurochemical research, , Volume: 35, Issue:1, 2010
Mitochondrial trafficking of APP and alpha synuclein: Relevance to mitochondrial dysfunction in Alzheimer's and Parkinson's diseases.Biochimica et biophysica acta, , Volume: 1802, Issue:1, 2010
Selective noradrenergic vulnerability in α-synuclein transgenic mice.Neurobiology of aging, , Volume: 31, Issue:12, 2010
Synergistic anti-Parkinsonism activity of high doses of B vitamins in a chronic cellular model.Neurobiology of aging, , Volume: 31, Issue:4, 2010
A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders.Biochimica et biophysica acta, , Volume: 1792, Issue:7, 2009
Oxidative stress involvement in alpha-synuclein oligomerization in Parkinson's disease cybrids.Antioxidants & redox signaling, , Volume: 11, Issue:3, 2009
Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases.Biochimica et biophysica acta, , Volume: 1790, Issue:7, 2009
[Sleep behavior disorder (RBD) in synucleionopaties].Glas. Srpska akademija nauka i umetnosti. Odeljenje medicinskih nauka, , Issue:50, 2009
Neurodegeneration in Parkinson's disease: genetics enlightens physiopathology.Journal of neural transmission. Supplementum, , Issue:73, 2009
Age and Parkinson's disease-related neuronal death in the substantia nigra pars compacta.Journal of neural transmission. Supplementum, , Issue:73, 2009
Thalamic changes in Parkinson's disease.Parkinsonism & related disorders, , Volume: 15 Suppl 3, 2009
Dissecting the potential molecular mechanisms underlying alpha-synuclein cell-to-cell transfer in Parkinson's disease.Parkinsonism & related disorders, , Volume: 15 Suppl 3, 2009
Neuropathology of non-motor features of Parkinson disease.Parkinsonism & related disorders, , Volume: 15 Suppl 3, 2009
Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.Neuron, , Dec-24, Volume: 64, Issue:6, 2009
alpha-synuclein and LRRK2: partners in crime.Neuron, , Dec-24, Volume: 64, Issue:6, 2009
[Pathophysiological process underlying Parkinson's disease: motor & non-motor symptoms].Rinsho shinkeigaku = Clinical neurology, , Volume: 49, Issue:11, 2009
[Pathogenesis of sporadic Parkinson's disease: contribution of genetic and environmental risk factors].Rinsho shinkeigaku = Clinical neurology, , Volume: 49, Issue:11, 2009
Creutzfeldt-jakob, Parkinson, lewy body dementia and Alzheimer diseases: from diagnosis to therapy.Central nervous system agents in medicinal chemistry, , Volume: 9, Issue:1, 2009
From genes to proteins in mendelian Parkinson's disease: an overview.Anatomical record (Hoboken, N.J. : 2007), , Volume: 292, Issue:12, 2009
Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson's disease model.Rejuvenation research, , Volume: 12, Issue:5, 2009
Stereotaxical infusion of rotenone: a reliable rodent model for Parkinson's disease.PloS one, , Nov-18, Volume: 4, Issue:11, 2009
Degeneration in different parkinsonian syndromes relates to astrocyte type and astrocyte protein expression.Journal of neuropathology and experimental neurology, , Volume: 68, Issue:10, 2009
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.Nature genetics, , Volume: 41, Issue:12, 2009
Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria.The Lancet. Neurology, , Volume: 8, Issue:12, 2009
Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells.Proceedings of the National Academy of Sciences of the United States of America, , Nov-24, Volume: 106, Issue:47, 2009
Alpha-synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population.Movement disorders : official journal of the Movement Disorder Society, , Dec-15, Volume: 24, Issue:16, 2009
Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip.The EMBO journal, , Dec-02, Volume: 28, Issue:23, 2009
Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Oct-28, Volume: 29, Issue:43, 2009
Modelling Parkinson's disease in Drosophila.Neuromolecular medicine, , Volume: 11, Issue:4, 2009
Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation.The Journal of clinical investigation, , Volume: 119, Issue:11, 2009
Dopamine D2 receptor knockout mice develop features of Parkinson disease.Annals of neurology, , Volume: 66, Issue:4, 2009
Concomitant progressive supranuclear palsy and multiple system atrophy: more than a simple twist of fate?Neuroscience letters, , Dec-31, Volume: 467, Issue:3, 2009
The morbid anatomy of dementia in Parkinson's disease.Acta neuropathologica, , Volume: 118, Issue:5, 2009
Parkin and PINK1 parkinsonism may represent nigral mitochondrial cytopathies distinct from Lewy body Parkinson's disease.Parkinsonism & related disorders, , Volume: 15, Issue:10, 2009
Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson's disease: an anatomical study.Acta neuropathologica, , Volume: 118, Issue:6, 2009
Mechanism of amyloidogenesis: nucleation-dependent fibrillation versus double-concerted fibrillation.BMB reports, , Sep-30, Volume: 42, Issue:9, 2009
The molecular chaperone Hsp90 modulates intermediate steps of amyloid assembly of the Parkinson-related protein alpha-synuclein.The Journal of biological chemistry, , Nov-06, Volume: 284, Issue:45, 2009
Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models.The EMBO journal, , Oct-21, Volume: 28, Issue:20, 2009
Relative preservation of thalamic centromedian nucleus in parkinsonian patients with dystonia.Movement disorders : official journal of the Movement Disorder Society, , Oct-30, Volume: 24, Issue:14, 2009
Dopamine-induced conformational changes in alpha-synuclein.PloS one, , Sep-04, Volume: 4, Issue:9, 2009
Pathologic findings in retinal pigment epithelial cell implantation for Parkinson disease.Neurology, , Oct-06, Volume: 73, Issue:14, 2009
Biological fluid biomarkers in neurodegenerative parkinsonism.Nature reviews. Neurology, , Volume: 5, Issue:10, 2009
Neurotoxic conversion of beta-synuclein: a novel approach to generate a transgenic mouse model of synucleinopathies?Journal of neurology, , Volume: 256 Suppl 3, 2009
Biochemical and pathological correlates of cognitive and behavioural change in DLB/PDD.Journal of neurology, , Volume: 256 Suppl 3, 2009
Formation and development of Lewy pathology: a critical update.Journal of neurology, , Volume: 256 Suppl 3, 2009
[Dual effects of different concentrations of alpha-synuclein on the neurotoxicity of 6-hydroxydopamine in SH-SY5Y cells].Sheng li xue bao : [Acta physiologica Sinica], , Aug-25, Volume: 61, Issue:4, 2009
Preferentially increased nitration of alpha-synuclein at tyrosine-39 in a cellular oxidative model of Parkinson's disease.Analytical chemistry, , Sep-15, Volume: 81, Issue:18, 2009
Taking the chemical out of chemical genetics.Nature chemical biology, , Volume: 5, Issue:9, 2009
Methylation status and neurodegenerative markers in Parkinson disease.Clinical chemistry, , Volume: 55, Issue:10, 2009
Interaction between alpha-synuclein and metal ions, still looking for a role in the pathogenesis of Parkinson's disease.Neuromolecular medicine, , Volume: 11, Issue:4, 2009
Is Parkinson's disease a prion disorder?Proceedings of the National Academy of Sciences of the United States of America, , Aug-04, Volume: 106, Issue:31, 2009
Clearance and phosphorylation of alpha-synuclein are inhibited in methionine sulfoxide reductase a null yeast cells.Journal of molecular neuroscience : MN, , Volume: 39, Issue:3, 2009
The ubiquitin ligase E6-AP promotes degradation of alpha-synuclein.Journal of neurochemistry, , Volume: 110, Issue:6, 2009
On the mechanism of nonspecific inhibitors of protein aggregation: dissecting the interactions of alpha-synuclein with Congo red and lacmoid.Biochemistry, , Sep-08, Volume: 48, Issue:35, 2009
Molecular pathogenesis of Parkinson disease: insights from genetic studies.Expert reviews in molecular medicine, , Jul-27, Volume: 11, 2009
Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein.The American journal of pathology, , Volume: 175, Issue:2, 2009
Repression of alpha-synuclein expression and toxicity by microRNA-7.Proceedings of the National Academy of Sciences of the United States of America, , Aug-04, Volume: 106, Issue:31, 2009
Threonine 53 in alpha-synuclein is conserved in long-living non-primate animals.Biochemical and biophysical research communications, , Sep-25, Volume: 387, Issue:3, 2009
Parkinson disease: extranigral, multisystem, and {alpha}-synuclein "plus".Archives of neurology, , Volume: 66, Issue:7, 2009
Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology.Neurobiology of disease, , Volume: 36, Issue:1, 2009
[Parkinson disease: genetics and neuronal death].Revue neurologique, , Volume: 165 Spec No 2, 2009
A triple-emission fluorescent probe reveals distinctive amyloid fibrillar polymorphism of wild-type alpha-synuclein and its familial Parkinson's disease mutants.Biochemistry, , Aug-11, Volume: 48, Issue:31, 2009
Trends in the molecular pathogenesis and clinical therapeutics of common neurodegenerative disorders.International journal of molecular sciences, , Jun-03, Volume: 10, Issue:6, 2009
Controlling aggregation propensity in A53T mutant of alpha-synuclein causing Parkinson's disease.Biochemical and biophysical research communications, , Sep-18, Volume: 387, Issue:2, 2009
[Genetics and present therapy options in Parkinson's disease: a review].Ideggyogyaszati szemle, , May-30, Volume: 62, Issue:5-6, 2009
Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications.Biochemical and biophysical research communications, , Sep-11, Volume: 387, Issue:1, 2009
Expanding the clinical phenotype of SNCA duplication carriers.Movement disorders : official journal of the Movement Disorder Society, , Sep-15, Volume: 24, Issue:12, 2009
Etiology and pathogenesis of Parkinson disease.Neurologic clinics, , Volume: 27, Issue:3, 2009
High-resolution temperature-concentration diagram of alpha-synuclein conformation obtained from a single Förster resonance energy transfer image in a microfluidic device.Analytical chemistry, , Aug-15, Volume: 81, Issue:16, 2009
Structural characterization of alpha-synuclein in an aggregation prone state.Protein science : a publication of the Protein Society, , Volume: 18, Issue:9, 2009
Binding of Cu(II) to human alpha-synucleins: comparison of wild type and the point mutations associated with the familial Parkinson's disease.The journal of physical chemistry. B, , Jul-16, Volume: 113, Issue:28, 2009
A single nucleotide polymorphism in the 3'UTR of the SNCA gene encoding alpha-synuclein is a new potential susceptibility locus for Parkinson disease.Neuroscience letters, , Sep-18, Volume: 461, Issue:2, 2009
Revelations and revolutions in the understanding of Parkinson's disease.Biochimica et biophysica acta, , Volume: 1792, Issue:7, 2009
Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein.Current protein & peptide science, , Volume: 10, Issue:5, 2009
Leucine-rich repeat kinase 2 expression leads to aggresome formation that is not associated with alpha-synuclein inclusions.Journal of neuropathology and experimental neurology, , Volume: 68, Issue:7, 2009
Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease.Journal of neuropathology and experimental neurology, , Volume: 68, Issue:5, 2009
Parkinson's disease.Lancet (London, England), , Jun-13, Volume: 373, Issue:9680, 2009
Clinical correlates of pathology in the claustrum in Parkinson's disease and dementia with Lewy bodies.Neuroscience letters, , Sep-11, Volume: 461, Issue:1, 2009
Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions.Neurobiology of disease, , Volume: 35, Issue:3, 2009
Aggregation-defective alpha-synuclein mutants inhibit the fibrillation of Parkinson's disease-linked alpha-synuclein variants.Biochemical and biophysical research communications, , Aug-14, Volume: 386, Issue:1, 2009
Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human alpha-synuclein in transgenic mouse brain.Human molecular genetics, , Sep-01, Volume: 18, Issue:17, 2009
Relationship between alpha synuclein phosphorylation, proteasomal inhibition and cell death: relevance to Parkinson's disease pathogenesis.Journal of neurochemistry, , Volume: 110, Issue:3, 2009
Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration.PloS one, , Jun-03, Volume: 4, Issue:6, 2009
Intrinsic disorder in proteins associated with neurodegenerative diseases.Frontiers in bioscience (Landmark edition), , 06-01, Volume: 14, Issue:14, 2009
Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases.Journal of neurochemistry, , Volume: 109, Issue:5, 2009
Reduction in QSART and vasoactive intestinal polypeptide expression in the skin of Parkinson's disease patients and its relation to dyshidrosis.Journal of cutaneous pathology, , Volume: 36, Issue:5, 2009
Charge neutralization and collapse of the C-terminal tail of alpha-synuclein at low pH.Protein science : a publication of the Protein Society, , Volume: 18, Issue:7, 2009
Rescue of alpha-synuclein cytotoxicity by insulin-like growth factors.Biochemical and biophysical research communications, , Jul-31, Volume: 385, Issue:3, 2009
Exploiting a (13)C-labelled heparin analogue for in situ solid-state NMR investigations of peptide-glycan interactions within amyloid fibrils.Organic & biomolecular chemistry, , Jun-07, Volume: 7, Issue:11, 2009
Alpha-synuclein induces migration of BV-2 microglial cells by up-regulation of CD44 and MT1-MMP.Journal of neurochemistry, , Volume: 109, Issue:5, 2009
The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson's disease.Journal of neurochemistry, , Volume: 110, Issue:1, 2009
On the mechanism of internalization of alpha-synuclein into microglia: roles of ganglioside GM1 and lipid raft.Journal of neurochemistry, , Volume: 110, Issue:1, 2009
The Parkinson disease-associated A30P mutation stabilizes alpha-synuclein against proteasomal degradation triggered by heme oxygenase-1 over-expression in human neuroblastoma cells.Journal of neurochemistry, , Volume: 110, Issue:2, 2009
Modulation of alpha-synuclein aggregation by dopamine: a review.Neurochemical research, , Volume: 34, Issue:10, 2009
Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy.PloS one, , Volume: 4, Issue:5, 2009
Role of autophagy and proteasome degradation pathways in apoptosis of PC12 cells overexpressing human alpha-synuclein.Neuroscience letters, , May-01, Volume: 454, Issue:3, 2009
The genetics of Parkinson's syndromes: a critical review.Current opinion in genetics & development, , Volume: 19, Issue:3, 2009
Alpha-synuclein and familial Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Jun-15, Volume: 24, Issue:8, 2009
Contribution of endogenous G-protein-coupled receptor kinases to Ser129 phosphorylation of alpha-synuclein in HEK293 cells.Biochemical and biophysical research communications, , Jul-03, Volume: 384, Issue:3, 2009
Relative contribution of simple mutations vs. copy number variations in five Parkinson disease genes in the Belgian population.Human mutation, , Volume: 30, Issue:7, 2009
Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction.Acta neuropathologica, , Volume: 117, Issue:6, 2009
Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element.International journal of molecular sciences, , Volume: 10, Issue:3, 2009
Modulation effect of filamentous phage on alpha-synuclein aggregation.Biochemical and biophysical research communications, , Jun-12, Volume: 383, Issue:4, 2009
[Causative gene and its associated gene for Parkinson disease and dystonia].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 61, Issue:4, 2009
[Pathological mechanisms of Parkinson's disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 61, Issue:4, 2009
Animal models of neurodegenerative diseases.Methods in molecular biology (Clifton, N.J.), , Volume: 549, 2009
Alpha-Synuclein contributes to GSK-3beta-catalyzed Tau phosphorylation in Parkinson's disease models.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 23, Issue:9, 2009
Dopamine and the dopamine oxidation product 5,6-dihydroxylindole promote distinct on-pathway and off-pathway aggregation of alpha-synuclein in a pH-dependent manner.Journal of molecular biology, , Apr-03, Volume: 387, Issue:3, 2009
Regional differences in the severity of Lewy body pathology across the olfactory cortex.Neuroscience letters, , Apr-03, Volume: 453, Issue:2, 2009
E46K Parkinson's-linked mutation enhances C-terminal-to-N-terminal contacts in alpha-synuclein.Journal of molecular biology, , May-22, Volume: 388, Issue:5, 2009
Mixed lineage kinase 2 and hippocalcin are localized in Lewy bodies of Parkinson's disease.Journal of the neurological sciences, , Jun-15, Volume: 281, Issue:1-2, 2009
Unique copper-induced oligomers mediate alpha-synuclein toxicity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 23, Issue:8, 2009
Protein degradation in Parkinson disease revisited: it's complex.The Journal of clinical investigation, , Volume: 119, Issue:3, 2009
Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease.Experimental neurology, , Volume: 218, Issue:2, 2009
Nitrated {alpha}-synuclein-induced alterations in microglial immunity are regulated by CD4+ T cell subsets.Journal of immunology (Baltimore, Md. : 1950), , Apr-01, Volume: 182, Issue:7, 2009
Parkinson's disease: from monogenic forms to genetic susceptibility factors.Human molecular genetics, , Apr-15, Volume: 18, Issue:R1, 2009
Anti-aggregation and fibril-destabilizing effects of sex hormones on alpha-synuclein fibrils in vitro.Experimental neurology, , Volume: 217, Issue:2, 2009
Nuclear and neuritic distribution of serine-129 phosphorylated alpha-synuclein in transgenic mice.Neuroscience, , Jun-02, Volume: 160, Issue:4, 2009
The therapeutic potential of LRRK2 and alpha-synuclein in Parkinson's disease.Antioxidants & redox signaling, , Volume: 11, Issue:9, 2009
Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , Mar-24, Volume: 106, Issue:12, 2009
Formation of dopamine-mediated alpha-synuclein-soluble oligomers requires methionine oxidation.Free radical biology & medicine, , May-15, Volume: 46, Issue:10, 2009
Protein misfolding and aggregation in Parkinson's disease.Antioxidants & redox signaling, , Volume: 11, Issue:9, 2009
PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease.PloS one, , Volume: 4, Issue:2, 2009
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation.The Journal of clinical investigation, , Volume: 119, Issue:3, 2009
Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-18, Volume: 29, Issue:7, 2009
Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease?Movement disorders : official journal of the Movement Disorder Society, , Apr-30, Volume: 24, Issue:6, 2009
Genomic and proteomic biomarkers for Parkinson disease.Neurology, , Feb-17, Volume: 72, Issue:7 Suppl, 2009
Alpha-synuclein binds large unilamellar vesicles as an extended helix.Biochemistry, , Mar-24, Volume: 48, Issue:11, 2009
Familial Parkinsonism and early onset Parkinson's disease in a Brazilian movement disorders clinic: phenotypic characterization and frequency of SNCA, PRKN, PINK1, and LRRK2 mutations.Movement disorders : official journal of the Movement Disorder Society, , Apr-15, Volume: 24, Issue:5, 2009
Alpha-synuclein, alcohol use disorders, and Parkinson disease: a case-control study.Parkinsonism & related disorders, , Volume: 15, Issue:6, 2009
Evidence against a reliable staging system of alpha-synuclein pathology in Parkinson's disease.Neuropathology and applied neurobiology, , Volume: 35, Issue:1, 2009
Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity.Nature genetics, , Volume: 41, Issue:3, 2009
Parkinson's disease dementia and dementia with Lewy bodies: different aspects of one entity.International psychogeriatrics, , Volume: 21, Issue:2, 2009
Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps.Apoptosis : an international journal on programmed cell death, , Volume: 14, Issue:4, 2009
Conversion of wild-type alpha-synuclein into mutant-type fibrils and its propagation in the presence of A30P mutant.The Journal of biological chemistry, , Mar-20, Volume: 284, Issue:12, 2009
Dissecting the mechanisms of tissue transglutaminase-induced cross-linking of alpha-synuclein: implications for the pathogenesis of Parkinson disease.The Journal of biological chemistry, , May-08, Volume: 284, Issue:19, 2009
Fluorescence microscopy and 3D image reconstruction of cytokine initiated disruption of the Parkinson disease associated proteins alpha-synuclein, tau and ubiquitin in cultured glial cells.Cytokine, , Volume: 45, Issue:3, 2009
Molecular basis of Parkinson's disease.Neuroreport, , Jan-28, Volume: 20, Issue:2, 2009
Induction of Parkinson disease-related proteins in motor neurons after transient spinal cord ischemia in rabbits.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, , Volume: 29, Issue:4, 2009
Detecting morphologically distinct oligomeric forms of alpha-synuclein.The Journal of biological chemistry, , Apr-24, Volume: 284, Issue:17, 2009
Effects of UCH-L1 on alpha-synuclein over-expression mouse model of Parkinson's disease.Journal of neurochemistry, , Volume: 108, Issue:4, 2009
Granular assembly of alpha-synuclein leading to the accelerated amyloid fibril formation with shear stress.PloS one, , Volume: 4, Issue:1, 2009
A pragmatic approach to biochemical systems theory applied to an alpha-synuclein-based model of Parkinson's disease.Journal of neuroscience methods, , Apr-15, Volume: 178, Issue:2, 2009
FGF20 and Parkinson's disease: no evidence of association or pathogenicity via alpha-synuclein expression.Movement disorders : official journal of the Movement Disorder Society, , Feb-15, Volume: 24, Issue:3, 2009
Toxic effects of dopamine metabolism in Parkinson's disease.Parkinsonism & related disorders, , Volume: 15 Suppl 1, 2009
Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy.Science (New York, N.Y.), , Jan-02, Volume: 323, Issue:5910, 2009
PAMAM dendrimers as potential agents against fibrillation of alpha-synuclein, a Parkinson's disease-related protein.Macromolecular bioscience, , Mar-10, Volume: 9, Issue:3, 2009
Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease.Human molecular genetics, , Mar-01, Volume: 18, Issue:5, 2009
Genetic susceptibility in Parkinson's disease.Biochimica et biophysica acta, , Volume: 1792, Issue:7, 2009
Can olfactory bulb biopsy be justified for the diagnosis of Parkinson's disease? Comments on "olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders".Acta neuropathologica, , Volume: 117, Issue:2, 2009
Proteomic profiling of phosphoproteins and glycoproteins responsive to wild-type alpha-synuclein accumulation and aggregation.Biochimica et biophysica acta, , Volume: 1794, Issue:2, 2009
Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss?Neuroscience letters, , Feb-06, Volume: 450, Issue:3, 2009
Smoking and Parkinson's disease: does nicotine affect alpha-synuclein fibrillation?Biochimica et biophysica acta, , Volume: 1794, Issue:2, 2009
Clinical and pathological characteristics of patients with leucine-rich repeat kinase-2 mutations.Movement disorders : official journal of the Movement Disorder Society, , Jan-15, Volume: 24, Issue:1, 2009
Genomewide association study for susceptibility genes contributing to familial Parkinson disease.Human genetics, , Volume: 124, Issue:6, 2009
Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders.Acta neuropathologica, , Volume: 117, Issue:2, 2009
Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders.Acta neuropathologica, , Volume: 117, Issue:2, 2009
Dopamine complexes of iron in the etiology and pathogenesis of Parkinson's disease.Journal of inorganic biochemistry, , Volume: 103, Issue:1, 2009
Genotypic and phenotypic characteristics of Dutch patients with early onset Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Jan-30, Volume: 24, Issue:2, 2009
Molecular mechanisms of alpha-synuclein neurodegeneration.Biochimica et biophysica acta, , Volume: 1792, Issue:7, 2009
Expression of Lewy body protein septin 4 in postmortem brain of Parkinson's disease and control subjects.Movement disorders : official journal of the Movement Disorder Society, , Jan-30, Volume: 24, Issue:2, 2009
Cellular glutathione peroxidase in human brain: cellular distribution, and its potential role in the degradation of Lewy bodies in Parkinson's disease and dementia with Lewy bodies.Acta neuropathologica, , Volume: 117, Issue:1, 2009
Intrabody and Parkinson's disease.Biochimica et biophysica acta, , Volume: 1792, Issue:7, 2009
Alpha-synuclein multiplications with parkinsonism, dementia or progressive myoclonus?Parkinsonism & related disorders, , Volume: 15, Issue:5, 2009
Intralaminar nuclei of the thalamus in Lewy body diseases.Brain research bulletin, , Feb-16, Volume: 78, Issue:2-3, 2009
Early stages for Parkinson's development: alpha-synuclein misfolding and aggregation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 4, Issue:1, 2009
Dementia and visual hallucinations associated with limbic pathology in Parkinson's disease.Parkinsonism & related disorders, , Volume: 15, Issue:3, 2009
Parkin attenuates wild-type tau modification in the presence of beta-amyloid and alpha-synuclein.Journal of molecular neuroscience : MN, , Volume: 37, Issue:1, 2009
Lrrk2 and alpha-synuclein are co-regulated in rodent striatum.Molecular and cellular neurosciences, , Volume: 39, Issue:4, 2008
Update on the pathogenesis of Parkinson's disease.Journal of neurology, , Volume: 255 Suppl 5, 2008
Structural characteristics of alpha-synuclein oligomers stabilized by the flavonoid baicalein.Journal of molecular biology, , Oct-31, Volume: 383, Issue:1, 2008
Novel suppressors of alpha-synuclein toxicity identified using yeast.Human molecular genetics, , Dec-01, Volume: 17, Issue:23, 2008
Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases.PloS one, , Sep-04, Volume: 3, Issue:9, 2008
Research in motion: the enigma of Parkinson's disease pathology spread.Nature reviews. Neuroscience, , Volume: 9, Issue:10, 2008
Insights into the effects of alpha-synuclein expression and proteasome inhibition on glutathione metabolism through a dynamic in silico model of Parkinson's disease: validation by cell culture data.Free radical biology & medicine, , Nov-01, Volume: 45, Issue:9, 2008
Cardiac sympathetic denervation in Parkinson's disease linked to SNCA duplication.Acta neuropathologica, , Volume: 116, Issue:5, 2008
[A new look at the corticostriatal-thalamocortical circuit in sporadic Parkinson's disease].Der Nervenarzt, , Volume: 79, Issue:12, 2008
Tissue transglutaminase modulates alpha-synuclein oligomerization.Protein science : a publication of the Protein Society, , Volume: 17, Issue:8, 2008
Cytokines disrupt intracellular patterns of Parkinson's disease-associated proteins alpha-synuclein, tau and ubiquitin in cultured glial cells.Brain research, , Jun-27, Volume: 1217, 2008
Decreased activities of lysosomal acid alpha-D-galactosidase A in the leukocytes of sporadic Parkinson's disease.Journal of the neurological sciences, , Aug-15, Volume: 271, Issue:1-2, 2008
Cu2+ binding modes of recombinant alpha-synuclein--insights from EPR spectroscopy.Journal of the American Chemical Society, , Jun-18, Volume: 130, Issue:24, 2008
Non-autonomous cell death in Parkinson's disease.The Lancet. Neurology, , Volume: 7, Issue:6, 2008
Multiple alpha-synuclein gene polymorphisms are associated with Parkinson's disease in a Norwegian population.Acta neurologica Scandinavica, , Volume: 118, Issue:5, 2008
Alpha-synuclein and Parkinson's disease: a proteomic view.Expert review of proteomics, , Volume: 5, Issue:2, 2008
Abnormal colonic motility in mice overexpressing human wild-type alpha-synuclein.Neuroreport, , May-28, Volume: 19, Issue:8, 2008
Nurr1 transcriptionally regulates the expression of alpha-synuclein.Neuroreport, , May-28, Volume: 19, Issue:8, 2008
Methionine sulfoxide reductase A protects dopaminergic cells from Parkinson's disease-related insults.Free radical biology & medicine, , Aug-01, Volume: 45, Issue:3, 2008
Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:5, 2008
Striatal beta-amyloid deposition in Parkinson disease with dementia.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:5, 2008
Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinson's disease.Glia, , Aug-15, Volume: 56, Issue:11, 2008
Controversies over the staging of alpha-synuclein pathology in Parkinson's disease.Acta neuropathologica, , Volume: 116, Issue:1, 2008
Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Jun-15, Volume: 23, Issue:8, 2008
Olfactory pathogenesis of idiopathic Parkinson disease revisited.Movement disorders : official journal of the Movement Disorder Society, , Jun-15, Volume: 23, Issue:8, 2008
Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification.Experimental cell research, , Jun-10, Volume: 314, Issue:10, 2008
Molecular determinants of the aggregation behavior of alpha- and beta-synuclein.Protein science : a publication of the Protein Society, , Volume: 17, Issue:5, 2008
Multiparametric fluorescence detection of early stages in the amyloid protein aggregation of pyrene-labeled alpha-synuclein.Journal of molecular biology, , May-16, Volume: 378, Issue:5, 2008
alpha-synuclein degradation by autophagic pathways: a potential key to Parkinson's disease pathogenesis.Autophagy, , Volume: 4, Issue:7, 2008
Progress in the pathogenesis and genetics of Parkinson's disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences, , Jun-27, Volume: 363, Issue:1500, 2008
Characterization of conformational and dynamic properties of natively unfolded human and mouse alpha-synuclein ensembles by NMR: implication for aggregation.Journal of molecular biology, , May-16, Volume: 378, Issue:5, 2008
Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: autonomic pathway implicated in Parkinson's disease?Neuroscience, , May-15, Volume: 153, Issue:3, 2008
Genetic association between alpha-synuclein and idiopathic Parkinson's disease.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, , Oct-05, Volume: 147B, Issue:7, 2008
Parkinson's disease. Signs of disease in fetal transplants.Science (New York, N.Y.), , Apr-11, Volume: 320, Issue:5873, 2008
Three-layered structure shared between Lewy bodies and lewy neurites-three-dimensional reconstruction of triple-labeled sections.Brain pathology (Zurich, Switzerland), , Volume: 18, Issue:3, 2008
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation.Nature medicine, , Volume: 14, Issue:5, 2008
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease.Nature medicine, , Volume: 14, Issue:5, 2008
The reaction of alpha-synuclein with tyrosinase: possible implications for Parkinson disease.The Journal of biological chemistry, , Jun-13, Volume: 283, Issue:24, 2008
Clinical, neuropathological and genotypic variability in SNCA A53T familial Parkinson's disease. Variability in familial Parkinson's disease.Acta neuropathologica, , Volume: 116, Issue:1, 2008
[Clinical and pathological study on early diagnosis of Parkinson's disease and dementia with Lewy bodies].Rinsho shinkeigaku = Clinical neurology, , Volume: 48, Issue:1, 2008
DJ-1 modulates alpha-synuclein aggregation state in a cellular model of oxidative stress: relevance for Parkinson's disease and involvement of HSP70.PloS one, , Apr-02, Volume: 3, Issue:4, 2008
Formation of toxic oligomeric alpha-synuclein species in living cells.PloS one, , Apr-02, Volume: 3, Issue:4, 2008
Detection of compounds that rescue Rab1-synuclein toxicity.Methods in enzymology, , Volume: 439, 2008
C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging.PLoS genetics, , Mar-21, Volume: 4, Issue:3, 2008
RNA interference mediated silencing of alpha-synuclein in MN9D cells and its effects on cell viability.Neuroscience bulletin, , Volume: 24, Issue:2, 2008
Patterns and stages of alpha-synucleinopathy: Relevance in a population-based cohort.Neurology, , Mar-25, Volume: 70, Issue:13, 2008
Selective detection, quantification, and subcellular location of alpha-synuclein aggregates with a protein aggregate filtration assay.BioTechniques, , Volume: 44, Issue:3, 2008
Quantitative proteomics of a presymptomatic A53T alpha-synuclein Drosophila model of Parkinson disease.Molecular & cellular proteomics : MCP, , Volume: 7, Issue:7, 2008
Analysis of PARK genes in a Korean cohort of early-onset Parkinson disease.Neurogenetics, , Volume: 9, Issue:4, 2008
New insights into the pathology of Parkinson's disease: does the peripheral autonomic system become central?European journal of neurology, , Volume: 15 Suppl 1, 2008
FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T.Journal of neurochemistry, , Volume: 106, Issue:1, 2008
Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies.Neuroscience, , Apr-09, Volume: 152, Issue:4, 2008
Differential expression of alpha-synuclein, parkin, and synphilin-1 isoforms in Lewy body disease.Neurogenetics, , Volume: 9, Issue:3, 2008
Elevated alpha-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease.Nucleic acids research, , Volume: 36, Issue:7, 2008
Characterization of fibrillation process of alpha-synuclein at the initial stage.Biochemical and biophysical research communications, , May-09, Volume: 369, Issue:3, 2008
Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies.Neuro-degenerative diseases, , Volume: 5, Issue:3-4, 2008
A not entirely benign procedure: progression of Parkinson's disease.Acta neuropathologica, , Volume: 115, Issue:4, 2008
Alpha-synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: lessons from viral transduction of knockout mice.Neuroscience letters, , Apr-11, Volume: 435, Issue:1, 2008
Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease.The Journal of clinical investigation, , Volume: 118, Issue:9, 2008
Genetic factors involved in the pathogenesis of Parkinson's disease.Brain research reviews, , Volume: 58, Issue:2, 2008
Generation of a alpha-synuclein-based rat model of Parkinson's disease.Neurobiology of disease, , Volume: 30, Issue:1, 2008
Genetic models of Parkinson's disease: mechanisms and therapies.SEB experimental biology series, , Volume: 60, 2008
Aggregopathy in neurodegenerative diseases: mechanisms and therapeutic implication.Neuro-degenerative diseases, , Volume: 5, Issue:6, 2008
Protein folding diseases and neurodegeneration: lessons learned from yeast.Biochimica et biophysica acta, , Volume: 1783, Issue:7, 2008
A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides.Nature neuroscience, , Volume: 11, Issue:3, 2008
The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease.Neuropathology and applied neurobiology, , Volume: 34, Issue:4, 2008
Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers.The Journal of biological chemistry, , Apr-18, Volume: 283, Issue:16, 2008
Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein.American journal of human genetics, , Volume: 82, Issue:2, 2008
Statins reduce neuronal alpha-synuclein aggregation in in vitro models of Parkinson's disease.Journal of neurochemistry, , Volume: 105, Issue:5, 2008
Olfactory deficits in mice overexpressing human wildtype alpha-synuclein.The European journal of neuroscience, , Volume: 28, Issue:2, 2008
Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain.The Journal of biological chemistry, , Apr-04, Volume: 283, Issue:14, 2008
Superoxide dismutase overexpression protects dopaminergic neurons in a Drosophila model of Parkinson's disease.Neurobiology of disease, , Volume: 30, Issue:1, 2008
Transgenic mice overexpressing tyrosine-to-cysteine mutant human alpha-synuclein: a progressive neurodegenerative model of diffuse Lewy body disease.The Journal of biological chemistry, , Apr-11, Volume: 283, Issue:15, 2008
Striatal beta-amyloid deposition in Parkinson disease with dementia.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:2, 2008
The effect of small molecules in modulating the chaperone activity of alphaB-crystallin against ordered and disordered protein aggregation.The FEBS journal, , Volume: 275, Issue:5, 2008
Ubiquitination of alpha-synuclein and autophagy in Parkinson's disease.Autophagy, , Volume: 4, Issue:3, 2008
Analysis of Parkinson disease patients from Portugal for mutations in SNCA, PRKN, PINK1 and LRRK2.BMC neurology, , Jan-22, Volume: 8, 2008
Exploring gene-environment interactions in Parkinson's disease.Human genetics, , Volume: 123, Issue:3, 2008
Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species.Biochemistry, , Sep-09, Volume: 47, Issue:36, 2008
Nitrated alpha-synuclein and microglial neuroregulatory activities.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 3, Issue:2, 2008
Clinicopathologic study of a SNCA gene duplication patient with Parkinson disease and dementia.Neurology, , Jan-15, Volume: 70, Issue:3, 2008
alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease.The Journal of biological chemistry, , Mar-14, Volume: 283, Issue:11, 2008
Transcriptional dysregulation in a transgenic model of Parkinson disease.Neurobiology of disease, , Volume: 29, Issue:3, 2008
The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease.Brain : a journal of neurology, , Volume: 131, Issue:Pt 8, 2008
Cortical alpha-synuclein load is associated with amyloid-beta plaque burden in a subset of Parkinson's disease patients.Acta neuropathologica, , Volume: 115, Issue:4, 2008
Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jan-09, Volume: 28, Issue:2, 2008
Is alpha-synuclein the culprit of the Parkinsonian neurodegeneration?Experimental neurology, , Volume: 209, Issue:1, 2008
The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease.Proceedings of the National Academy of Sciences of the United States of America, , Jan-15, Volume: 105, Issue:2, 2008
Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy.The Journal of clinical investigation, , Volume: 118, Issue:2, 2008
Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae.Molecular biology of the cell, , Volume: 19, Issue:3, 2008
Noninvasive measurement of protein aggregation by mutant huntingtin fragments or alpha-synuclein in the lens.The Journal of biological chemistry, , Mar-07, Volume: 283, Issue:10, 2008
alpha-Synuclein gene duplications in sporadic Parkinson disease.Neurology, , Jan-01, Volume: 70, Issue:1, 2008
Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 22, Issue:5, 2008
Origins and effects of extracellular alpha-synuclein: implications in Parkinson's disease.Journal of molecular neuroscience : MN, , Volume: 34, Issue:1, 2008
Changes in interfacial properties of alpha-synuclein preceding its aggregation.The Analyst, , Volume: 133, Issue:1, 2008
Alpha-synuclein selectively binds to anionic phospholipids embedded in liquid-disordered domains.Journal of molecular biology, , Feb-01, Volume: 375, Issue:5, 2008
Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease.Brain : a journal of neurology, , Volume: 131, Issue:Pt 3, 2008
Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death.Human molecular genetics, , Mar-15, Volume: 17, Issue:6, 2008
Oxidative-stress-induced apoptosis in PBLs of two patients with Parkinson disease secondary to alpha-synuclein mutation.Journal of the neurological sciences, , Apr-15, Volume: 267, Issue:1-2, 2008
Complex I deficiency in Parkinson's disease frontal cortex.Brain research, , Jan-16, Volume: 1189, 2008
Characterization of the striatal 6-OHDA model of Parkinson's disease in wild type and alpha-synuclein-deleted mice.Experimental neurology, , Volume: 210, Issue:1, 2008
The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease: a critical analysis of alpha-synuclein staging.Neuropathology and applied neurobiology, , Volume: 34, Issue:3, 2008
Commentary to "Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease".Neurochemical research, , Volume: 33, Issue:6, 2008
Glial reactions in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Mar-15, Volume: 23, Issue:4, 2008
Dopamine differentially induces aggregation of A53T mutant and wild type alpha-synuclein: insights into the protein chemistry of Parkinson's disease.Biochemical and biophysical research communications, , Jan-25, Volume: 365, Issue:4, 2008
Nitrated alpha-synuclein-activated microglial profiling for Parkinson's disease.Journal of neurochemistry, , Volume: 104, Issue:6, 2008
Autonomic dysfunction in RBD--what can it teach us about disease progression?Sleep medicine, , Volume: 9, Issue:5, 2008
Preventing effects of a novel anti-parkinsonian agent zonisamide on dopamine quinone formation.Neuroscience research, , Volume: 60, Issue:1, 2008
alpha-Synuclein pathology in the neostriatum in Parkinson's disease.Acta neuropathologica, , Volume: 115, Issue:4, 2008
Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies.Acta neuropathologica, , Volume: 115, Issue:4, 2008
Spermine binding to Parkinson's protein alpha-synuclein and its disease-related A30P and A53T mutants.The journal of physical chemistry. B, , Sep-04, Volume: 112, Issue:35, 2008
Synphilin-1 isoforms in Parkinson's disease: regulation by phosphorylation and ubiquitylation.Cellular and molecular life sciences : CMLS, , Volume: 65, Issue:1, 2008
LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease.Neuropathology and applied neurobiology, , Volume: 34, Issue:3, 2008
Impact of Tyr to Ala mutations on alpha-synuclein fibrillation and structural properties.Biochimica et biophysica acta, , Volume: 1782, Issue:10, 2008
Parkinson's disease with Onuf's nucleus involvement mimicking multiple system atrophy.Journal of neurology, neurosurgery, and psychiatry, , Volume: 79, Issue:2, 2008
In vivo alpha-synuclein overexpression in rodents: a useful model of Parkinson's disease?Experimental neurology, , Volume: 209, Issue:1, 2008
Proteomics of Caenorhabditis elegans over-expressing human alpha-synuclein analyzed by fluorogenic derivatization-liquid chromatography/tandem mass spectrometry: identification of actin and several ribosomal proteins as negative markers at early ParkinsonBiomedical chromatography : BMC, , Volume: 22, Issue:3, 2008
Controlling the mass action of alpha-synuclein in Parkinson's disease.Journal of neurochemistry, , Volume: 107, Issue:2, 2008
Alpha-synuclein promoter haplotypes and dementia in Parkinson's disease.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, , Apr-05, Volume: 147, Issue:3, 2008
Dopamine receptor agonists reverse behavioral abnormalities of alpha-synuclein transgenic mouse, a new model of Parkinson's disease.Journal of neuroscience research, , Feb-15, Volume: 86, Issue:3, 2008
Localization of CKII beta subunits in Lewy bodies of Parkinson's disease.Journal of the neurological sciences, , Mar-15, Volume: 266, Issue:1-2, 2008
Proteome response to the panneural expression of human wild-type alpha-synuclein: a Drosophila model of Parkinson's disease.Journal of proteome research, , Volume: 7, Issue:9, 2008
Mitochondrial alterations in Parkinson's disease: new clues.Journal of neurochemistry, , Volume: 107, Issue:2, 2008
Human-based studies on alpha-synuclein deposition and relationship to Parkinson's disease symptoms.Experimental neurology, , Volume: 209, Issue:1, 2008
alpha-Synuclein gene duplication is present in sporadic Parkinson disease.Neurology, , Jan-01, Volume: 70, Issue:1, 2008
Genetics of iron regulation and the possible role of iron in Parkinson's disease.Neurobiology of disease, , Volume: 32, Issue:2, 2008
Immunological features of alpha-synuclein in Parkinson's disease.Journal of cellular and molecular medicine, , Volume: 12, Issue:5B, 2008
Risk and protective haplotypes of the alpha-synuclein gene associated with Parkinson's disease differentially affect cognitive sequence learning.Genes, brain, and behavior, , Volume: 7, Issue:1, 2008
GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , Aug-05, Volume: 105, Issue:31, 2008
Mutant alpha-synuclein exacerbates age-related decrease of neurogenesis.Neurobiology of aging, , Volume: 29, Issue:6, 2008
Early alpha-synuclein lipoxidation in neocortex in Lewy body diseases.Neurobiology of aging, , Volume: 29, Issue:3, 2008
[Cellular pathophysiology of Parkinson's disease].Rinsho shinkeigaku = Clinical neurology, , Volume: 48, Issue:11, 2008
[Recent progress in Parkinson's disease].Rinsho shinkeigaku = Clinical neurology, , Volume: 48, Issue:11, 2008
[Lewy body formation in Parkinson's disease: neurodegeneration or neuroprotection?].Rinsho shinkeigaku = Clinical neurology, , Volume: 48, Issue:11, 2008
[Clinical and pathological study on early diagnosis of Parkinson's disease and dementia with Lewy bodies].Rinsho shinkeigaku = Clinical neurology, , Volume: 48, Issue:11, 2008
Nigral burden of alpha-synuclein correlates with striatal dopamine deficit.Movement disorders : official journal of the Movement Disorder Society, , Aug-15, Volume: 23, Issue:11, 2008
What causes cell death in Parkinson's disease?Annals of neurology, , Volume: 64 Suppl 2, 2008
Pink1 suppresses alpha-synuclein-induced phenotypes in a Drosophila model of Parkinson's disease.Genome, , Volume: 51, Issue:12, 2008
Alpha-synuclein assembly as a therapeutic target of Parkinson's disease and related disorders.Current pharmaceutical design, , Volume: 14, Issue:30, 2008
A critical evaluation of the Braak staging scheme for Parkinson's disease.Annals of neurology, , Volume: 64, Issue:5, 2008
Application of a C. elegans dopamine neuron degeneration assay for the validation of potential Parkinson's disease genes.Journal of visualized experiments : JoVE, , Jul-18, Issue:17, 2008
Alpha-Synuclein conformation affects its tyrosine-dependent oxidative aggregation.Biochemistry, , Dec-23, Volume: 47, Issue:51, 2008
Pathological lesions in colonic biopsies during Parkinson's disease.Gut, , Volume: 57, Issue:12, 2008
Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease.The FEBS journal, , Volume: 275, Issue:23, 2008
Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2.The FEBS journal, , Volume: 275, Issue:23, 2008
Emerging pathways in genetic Parkinson's disease.The FEBS journal, , Volume: 275, Issue:23, 2008
Targeted overexpression of human alpha-synuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson disease.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:12, 2008
LRRK2 and parkin immunoreactivity in multiple system atrophy inclusions.Acta neuropathologica, , Volume: 116, Issue:6, 2008
Membrane binding of oligomeric alpha-synuclein depends on bilayer charge and packing.FEBS letters, , Nov-12, Volume: 582, Issue:27, 2008
[Alpha-synuclein interacted proteins: the relevance with the pathogenesis of Parkinson's disease].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, , Volume: 37, Issue:5, 2008
Mechanism of alpha-synuclein oligomerization and membrane interaction: theoretical approach to unstructured proteins studies.Nanomedicine : nanotechnology, biology, and medicine, , Volume: 4, Issue:4, 2008
On the pathogenesis and neuroprotective treatment of Parkinson disease: what have we learned from the genetic forms of this disease?Current medicinal chemistry, , Volume: 15, Issue:23, 2008
Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region.PloS one, , Volume: 3, Issue:10, 2008
Re: Alpha-synuclein gene duplication is present in sporadic Parkinson disease.Neurology, , Oct-14, Volume: 71, Issue:16, 2008
Re: Alpha-synuclein gene duplication is present in sporadic Parkinson disease.Neurology, , Oct-14, Volume: 71, Issue:16, 2008
N-terminal region of alpha-synuclein is essential for the fatty acid-induced oligomerization of the molecules.FEBS letters, , Oct-29, Volume: 582, Issue:25-26, 2008
Mathematical approach to understand the kinetics of alpha-synuclein aggregation: relevance to Parkinson's disease.Computers in biology and medicine, , Volume: 38, Issue:10, 2008
Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors.BMC neuroscience, , Sep-22, Volume: 9, 2008
Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies.Journal of neuropathology and experimental neurology, , Volume: 67, Issue:10, 2008
Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson.Biochimica et biophysica acta, , Volume: 1783, Issue:10, 2008
The genetics and molecular biology of alpha-synuclein.Handbook of clinical neurology, , Volume: 89, 2008
Alpha-synuclein A30P point-mutation generates age-dependent nigrostriatal deficiency in mice.Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, , Volume: 59, Issue:2, 2008
Cerebellar alpha-synuclein levels are decreased in Parkinson's disease and do not correlate with SNCA polymorphisms associated with disease in a Swedish material.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 22, Issue:10, 2008
Viral vectors, animal models and new therapies for Parkinson's disease.Parkinsonism & related disorders, , Volume: 14 Suppl 2, 2008
Fas-associated factor 1 and Parkinson's disease.Neurobiology of disease, , Volume: 31, Issue:3, 2008
Genomic investigation of alpha-synuclein multiplication and parkinsonism.Annals of neurology, , Volume: 63, Issue:6, 2008
Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease.Human genetics, , Volume: 124, Issue:1, 2008
Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells.The Journal of biological chemistry, , Aug-29, Volume: 283, Issue:35, 2008
Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders.Autoimmunity reviews, , Volume: 7, Issue:6, 2008
Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy.The Journal of biological chemistry, , Aug-29, Volume: 283, Issue:35, 2008
Protein array analysis of oligomerization-induced changes in alpha-synuclein protein-protein interactions points to an interference with Cdc42 effector proteins.Neuroscience, , Jul-17, Volume: 154, Issue:4, 2008
Solid-state NMR reveals structural differences between fibrils of wild-type and disease-related A53T mutant alpha-synuclein.Journal of molecular biology, , Jul-11, Volume: 380, Issue:3, 2008
On the key role played by altered protein conformation in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 115, Issue:9, 2008
Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease.Neuroscience letters, , Jul-11, Volume: 439, Issue:2, 2008
The alpha-synuclein burden hypothesis of Parkinson disease and its relationship to Alzheimer disease.Experimental neurology, , Volume: 212, Issue:2, 2008
Parkinson patient fibroblasts show increased alpha-synuclein expression.Experimental neurology, , Volume: 212, Issue:2, 2008
Clinical genetics of Parkinson's disease and related disorders.Parkinsonism & related disorders, , Volume: 13 Suppl 3, 2007
Neuropathology of Parkinson's disease dementia and dementia with Lewy bodies with reference to striatal pathology.Parkinsonism & related disorders, , Volume: 13 Suppl 3, 2007
[Animal models for familial Parkinson's disease].Rinsho shinkeigaku = Clinical neurology, , Volume: 47, Issue:11, 2007
Update on the genetics of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 22 Suppl 17, 2007
The pathogenesis of cell death in Parkinson's disease--2007.Movement disorders : official journal of the Movement Disorder Society, , Volume: 22 Suppl 17, 2007
Polyunsaturated fatty acids induce alpha-synuclein-related pathogenic changes in neuronal cells.The American journal of pathology, , Volume: 171, Issue:6, 2007
The Lewy body in Parkinson's disease: molecules implicated in the formation and degradation of alpha-synuclein aggregates.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 27, Issue:5, 2007
Pathological biochemistry of alpha-synucleinopathy.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 27, Issue:5, 2007
Multiplex ligation-dependent probe amplification assay for simultaneous detection of Parkinson's disease gene rearrangements.Movement disorders : official journal of the Movement Disorder Society, , Nov-15, Volume: 22, Issue:15, 2007
Parkinson's disease.Human molecular genetics, , Oct-15, Volume: 16 Spec No. 2, 2007
Angiotensin II protects against alpha-synuclein toxicity and reduces protein aggregation in vitro.Biochemical and biophysical research communications, , Nov-23, Volume: 363, Issue:3, 2007
Conformation-specific binding of alpha-synuclein to novel protein partners detected by phage display and NMR spectroscopy.The Journal of biological chemistry, , Nov-23, Volume: 282, Issue:47, 2007
alpha-Synuclein and Parkinson disease susceptibility.Neurology, , Oct-30, Volume: 69, Issue:18, 2007
Transgenic animal models of neurodegenerative diseases and their application to treatment development.Advanced drug delivery reviews, , Sep-30, Volume: 59, Issue:11, 2007
[Pathology of familial Parkinson's disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 59, Issue:8, 2007
[Relationship between alpha-synuclein and Parkinson's disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 59, Issue:8, 2007
[Molecular genetics of Parkinson's disease].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 59, Issue:8, 2007
The effect of truncated human alpha-synuclein (1-120) on dopaminergic cells in a transgenic mouse model of Parkinson's disease.Cell transplantation, , Volume: 16, Issue:5, 2007
In parkinsonian substantia nigra, alpha-synuclein is modified by acrolein, a lipid-peroxidation product, and accumulates in the dopamine neurons with inhibition of proteasome activity.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 114, Issue:12, 2007
Lifetime proteomic profiling of an A30P alpha-synuclein Drosophila model of Parkinson's disease.Journal of proteome research, , Volume: 6, Issue:9, 2007
Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease.Annals of neurology, , Volume: 62, Issue:2, 2007
Identification of proteins involved in microglial endocytosis of alpha-synuclein.Journal of proteome research, , Volume: 6, Issue:9, 2007
Medicine. The yin-yang of sirtuins.Science (New York, N.Y.), , Jul-27, Volume: 317, Issue:5837, 2007
Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases.Acta neuropathologica, , Volume: 114, Issue:3, 2007
Mechanistic aspects of Parkinson's disease: alpha-synuclein and the biomembrane.Cell biochemistry and biophysics, , Volume: 47, Issue:2, 2007
Impact of recent genetic findings in Parkinson's disease.Current opinion in neurology, , Volume: 20, Issue:4, 2007
Physiological and pathological properties of alpha-synuclein.Cellular and molecular life sciences : CMLS, , Volume: 64, Issue:17, 2007
Classical Parkinson disease versus Parkinson complex--reflections against staging and in favour of heterogeneity.European journal of neurology, , Volume: 14, Issue:7, 2007
Transgenic mice with human mutant genes causing Parkinson's disease and amyotrophic lateral sclerosis provide common insight into mechanisms of motor neuron selective vulnerability to degeneration.Reviews in the neurosciences, , Volume: 18, Issue:2, 2007
Effect of alpha-synuclein on the promoter activity of tyrosine hydroxylase gene.Neuroscience bulletin, , Volume: 23, Issue:1, 2007
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.Science (New York, N.Y.), , Jul-27, Volume: 317, Issue:5837, 2007
YGR198w (YPP1) targets A30P alpha-synuclein to the vacuole for degradation.The Journal of cell biology, , Jun-18, Volume: 177, Issue:6, 2007
Development of alpha-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease.Acta neuropathologica, , Volume: 114, Issue:3, 2007
Genetics of Parkinson's disease and parkinsonism.Expert review of neurotherapeutics, , Volume: 7, Issue:6, 2007
Autosomal dominant Parkinson's disease and the route to new therapies.Expert review of neurotherapeutics, , Volume: 7, Issue:6, 2007
Tilted properties of the 67-78 fragment of alpha-synuclein are responsible for membrane destabilization and neurotoxicity.Proteins, , Sep-01, Volume: 68, Issue:4, 2007
Alpha-synuclein pathology in the olfactory pathways of dementia patients.Journal of anatomy, , Volume: 211, Issue:1, 2007
Do alpha-synuclein aggregates in autonomic plexuses predate Lewy body disorders?: a cohort study.Neurology, , Jun-05, Volume: 68, Issue:23, 2007
Nitration in neurodegeneration: deciphering the "Hows" "nYs".Biochemistry, , Jun-26, Volume: 46, Issue:25, 2007
Thermodynamics imprinting reveals differential binding of metals to alpha-synuclein: relevance to Parkinson's disease.Biochemical and biophysical research communications, , Jul-20, Volume: 359, Issue:1, 2007
The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states.Biochemistry, , Jun-19, Volume: 46, Issue:24, 2007
Merging mouse transcriptome analyses with Parkinson's disease linkage studies.DNA research : an international journal for rapid publication of reports on genes and genomes, , Volume: 14, Issue:2, 2007
Therapeutic approaches to inflammation in neurodegenerative disease.Current opinion in neurology, , Volume: 20, Issue:3, 2007
Hypocretin (orexin) cell loss in Parkinson's disease.Brain : a journal of neurology, , Volume: 130, Issue:Pt 6, 2007
The Ala53Thr mutation in the alpha-synuclein gene in a Korean family with Parkinson disease.Clinical genetics, , Volume: 71, Issue:5, 2007
Expression of alpha-synuclein, a presynaptic protein implicated in Parkinson's disease, in erythropoietic lineage.Biochemical and biophysical research communications, , Jun-22, Volume: 358, Issue:1, 2007
Expanding insights on the involvement of endoplasmic reticulum stress in Parkinson's disease.Antioxidants & redox signaling, , Volume: 9, Issue:5, 2007
Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation.The American journal of pathology, , Volume: 170, Issue:5, 2007
Pharmacological inhibition of PARP-1 reduces alpha-synuclein- and MPP+-induced cytotoxicity in Parkinson's disease in vitro models.Biochemical and biophysical research communications, , Jun-08, Volume: 357, Issue:3, 2007
Autoantibodies to alpha-synuclein in inherited Parkinson's disease.Journal of neurochemistry, , Volume: 101, Issue:3, 2007
A cell-based model of alpha-synucleinopathy for screening compounds with therapeutic potential of Parkinson's disease.Acta pharmacologica Sinica, , Volume: 28, Issue:5, 2007
Transcranial ultrasound in different monogenetic subtypes of Parkinson's disease.Journal of neurology, , Volume: 254, Issue:5, 2007
Pathogenic mutations in Parkinson disease.Human mutation, , Volume: 28, Issue:7, 2007
Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-21, Volume: 27, Issue:12, 2007
Expression of alpha-synuclein mRNA in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , May-15, Volume: 22, Issue:7, 2007
Prime time for alpha-synuclein.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-07, Volume: 27, Issue:10, 2007
Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation.The Journal of biological chemistry, , Apr-27, Volume: 282, Issue:17, 2007
The 5'-untranslated region of Parkinson's disease alpha-synuclein messengerRNA contains a predicted iron responsive element.Molecular psychiatry, , Volume: 12, Issue:3, 2007
Role of mitochondrial dysfunction in Parkinson's disease: Implications for treatment.Drugs & aging, , Volume: 24, Issue:2, 2007
Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation.Human molecular genetics, , Mar-15, Volume: 16, Issue:6, 2007
Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain.Brain : a journal of neurology, , Volume: 130, Issue:Pt 3, 2007
Observation of multiple intermediates in alpha-synuclein fibril formation by singular value decomposition analysis.Biochemical and biophysical research communications, , Apr-06, Volume: 355, Issue:2, 2007
Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity.Neuron, , Feb-15, Volume: 53, Issue:4, 2007
Climbing the scaffolds of Parkinson's disease pathogenesis.Neuron, , Feb-15, Volume: 53, Issue:4, 2007
Parkinson's disease: lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre- and postganglionic neurons.Acta neuropathologica, , Volume: 113, Issue:4, 2007
Association of alpha-synuclein gene haplotypes with Parkinson's disease.Parkinsonism & related disorders, , Volume: 13, Issue:6, 2007
Plasma alpha-synuclein is decreased in subjects with Parkinson's disease.Experimental neurology, , Volume: 204, Issue:2, 2007
Pesticide exposure exacerbates alpha-synucleinopathy in an A53T transgenic mouse model.The American journal of pathology, , Volume: 170, Issue:2, 2007
Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD.Experimental neurology, , Volume: 204, Issue:1, 2007
Activation of the unfolded protein response in Parkinson's disease.Biochemical and biophysical research communications, , Mar-16, Volume: 354, Issue:3, 2007
The dopaminergic nigrostriatal system and Parkinson's disease: molecular events in development, disease, and cell death, and new therapeutic strategies.Neurosurgery, , Volume: 60, Issue:1, 2007
Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity.Journal of molecular biology, , Mar-09, Volume: 366, Issue:5, 2007
Screening for SNCA and LRRK2 mutations in Greek sporadic and autosomal dominant Parkinson's disease: identification of two novel LRRK2 variants.European journal of neurology, , Volume: 14, Issue:1, 2007
PINK1, a gene product of PARK6, accumulates in alpha-synucleinopathy brains.Journal of neurology, neurosurgery, and psychiatry, , Volume: 78, Issue:6, 2007
Isomers of human alpha-synuclein stabilized by disulfide bonds exhibit distinct structural and aggregative properties.Biochemistry, , Jan-16, Volume: 46, Issue:2, 2007
Dopamine affects the stability, hydration, and packing of protofibrils and fibrils of the wild type and variants of alpha-synuclein.Biochemistry, , Jan-16, Volume: 46, Issue:2, 2007
Protein expression in a Drosophila model of Parkinson's disease.Journal of proteome research, , Volume: 6, Issue:1, 2007
Effect of 4-hydroxy-2-nonenal modification on alpha-synuclein aggregation.The Journal of biological chemistry, , Feb-23, Volume: 282, Issue:8, 2007
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.The Journal of biological chemistry, , Feb-23, Volume: 282, Issue:8, 2007
Vitamin A potently destabilizes preformed alpha-synuclein fibrils in vitro: implications for Lewy body diseases.Neurobiology of disease, , Volume: 25, Issue:2, 2007
Neuropathology of Parkinson's disease associated with the LRRK2 Ile1371Val mutation.Movement disorders : official journal of the Movement Disorder Society, , Jan-15, Volume: 22, Issue:2, 2007
The ups and downs of alpha-synuclein mRNA expression.Movement disorders : official journal of the Movement Disorder Society, , Jan-15, Volume: 22, Issue:2, 2007
Phosphorylation-dependent metal binding by alpha-synuclein peptide fragments.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, , Volume: 12, Issue:2, 2007
Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?Neurobiology of disease, , Volume: 25, Issue:1, 2007
Dynamics of tyrosine hydroxylase mediated regulation of dopamine synthesis.Journal of computational neuroscience, , Volume: 22, Issue:2, 2007
Glutathione S-transferase polymorphisms and onset age in alpha-synuclein A53T mutant Parkinson's disease.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, , Mar-05, Volume: 144B, Issue:2, 2007
Parkinson's disease genetic mutations increase cell susceptibility to stress: mutant alpha-synuclein enhances H2O2- and Sin-1-induced cell death.Neurobiology of aging, , Volume: 28, Issue:11, 2007
Identification of novel proteins associated with both alpha-synuclein and DJ-1.Molecular & cellular proteomics : MCP, , Volume: 6, Issue:5, 2007
Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression.Neurobiology of aging, , Volume: 28, Issue:2, 2007
Effect of reparation of repeat sequences in the human alpha-synuclein on fibrillation ability.International journal of biological sciences, , Oct-02, Volume: 3, Issue:1, 2006
Rescuing defective vesicular trafficking protects against alpha-synuclein toxicity in cellular and animal models of Parkinson's disease.ACS chemical biology, , Aug-22, Volume: 1, Issue:7, 2006
Differences in neuropathologic characteristics across the Lewy body dementia spectrum.Neurology, , Dec-12, Volume: 67, Issue:11, 2006
Impairment of microtubule-dependent trafficking by overexpression of alpha-synuclein.The European journal of neuroscience, , Volume: 24, Issue:11, 2006
alpha-Synuclein, oxidative stress and apoptosis from the perspective of a yeast model of Parkinson's disease.FEMS yeast research, , Volume: 6, Issue:8, 2006
[The neuroprotective B2 strengthens the aggregation of unfolded protein in Huntington chorea and Parkinson disease].Pharmazie in unserer Zeit, , Volume: 35, Issue:6, 2006
Viral vectors as a tool to model and treat Parkinson's disease.Wiener klinische Wochenschrift, , Volume: 118, Issue:19-20, 2006
Cortical Lewy body disease and Parkinson's disease dementia.Current opinion in neurology, , Volume: 19, Issue:6, 2006
Identification of a risk haplotype of the alpha-synuclein gene in Japanese with sporadic Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 21, Issue:12, 2006
Genetics of Parkinson's disease and parkinsonism.Annals of neurology, , Volume: 60, Issue:4, 2006
Understanding the molecular causes of Parkinson's disease.Trends in molecular medicine, , Volume: 12, Issue:11, 2006
Molecular mechanisms of nigral neurodegeneration in Park2 and regulation of parkin protein by other proteins.Journal of neural transmission. Supplementum, , Issue:70, 2006
Progress in familial Parkinson's disease.Journal of neural transmission. Supplementum, , Issue:70, 2006
Genetic causes of Parkinson's disease: extending the pathway.Journal of neural transmission. Supplementum, , Issue:70, 2006
New face of neuromelanin.Journal of neural transmission. Supplementum, , Issue:70, 2006
Pathology associated with sporadic Parkinson's disease--where does it end?Journal of neural transmission. Supplementum, , Issue:70, 2006
Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery.Neuron, , Oct-05, Volume: 52, Issue:1, 2006
Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Sep-27, Volume: 26, Issue:39, 2006
[What can we learn from genes responsible for familial forms of Parkinson's disease?].Bulletin de l'Academie nationale de medecine, , Volume: 190, Issue:2, 2006
[Familial Parkinsonism].No to shinkei = Brain and nerve, , Volume: 58, Issue:8, 2006
Isolating recombinant antibodies against specific protein morphologies using atomic force microscopy and phage display technologies.Protein engineering, design & selection : PEDS, , Volume: 19, Issue:11, 2006
A spectroscopic study of some of the peptidyl radicals formed following hydroxyl radical attack on beta-amyloid and alpha-synuclein.Free radical research, , Volume: 40, Issue:7, 2006
Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells.Journal of neurochemistry, , Volume: 99, Issue:4, 2006
The aggregation and fibrillation of alpha-synuclein.Accounts of chemical research, , Volume: 39, Issue:9, 2006
Histone deacetylase (HDAC) 4 involvement in both Lewy and Marinesco bodies.Neuropathology and applied neurobiology, , Volume: 32, Issue:5, 2006
Synphilin isoforms and the search for a cellular model of lewy body formation in Parkinson's disease.Cell cycle (Georgetown, Tex.), , Volume: 5, Issue:18, 2006
PEP-1-SOD fusion protein efficiently protects against paraquat-induced dopaminergic neuron damage in a Parkinson disease mouse model.Free radical biology & medicine, , Oct-01, Volume: 41, Issue:7, 2006
Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity.Human molecular genetics, , Oct-15, Volume: 15, Issue:20, 2006
Beta-synuclein modulates alpha-synuclein neurotoxicity by reducing alpha-synuclein protein expression.Human molecular genetics, , Oct-15, Volume: 15, Issue:20, 2006
alpha-Synuclein is colocalized with 14-3-3 and synphilin-1 in A53T transgenic mice.Acta neuropathologica, , Volume: 112, Issue:6, 2006
The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Sep-06, Volume: 26, Issue:36, 2006
Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease.Experimental & molecular medicine, , Aug-31, Volume: 38, Issue:4, 2006
Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease.Neurochemical research, , Volume: 31, Issue:9, 2006
No definitive evidence for a role for the environment in the etiology of Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 21, Issue:10, 2006
Behavioral effects of dopaminergic agonists in transgenic mice overexpressing human wildtype alpha-synuclein.Neuroscience, , Nov-03, Volume: 142, Issue:4, 2006
Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease.Biochemical and biophysical research communications, , Oct-13, Volume: 349, Issue:1, 2006
Cytosolic proteins regulate alpha-synuclein dissociation from presynaptic membranes.The Journal of biological chemistry, , Oct-27, Volume: 281, Issue:43, 2006
[Ubiquitin and Parkinson's disease].Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, , Volume: 51, Issue:10 Suppl, 2006
Dynamic modeling of alpha-synuclein aggregation for the sporadic and genetic forms of Parkinson's disease.Neuroscience, , Oct-27, Volume: 142, Issue:3, 2006
Nuclear localization of the 20S proteasome subunit in Parkinson's disease.Neuroscience letters, , Oct-02, Volume: 406, Issue:1-2, 2006
alpha-synuclein from platelets is not phosphorylated at serine 129 in Parkinson's disease and multiple system atrophy.Neuroscience letters, , Sep-25, Volume: 405, Issue:3, 2006
Beta-amlyoid 1-42 and tau-protein in cerebrospinal fluid of patients with Parkinson's disease dementia.Dementia and geriatric cognitive disorders, , Volume: 22, Issue:3, 2006
Relationship among alpha-synuclein accumulation, dopamine synthesis, and neurodegeneration in Parkinson disease substantia nigra.Journal of neuropathology and experimental neurology, , Volume: 65, Issue:8, 2006
Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease.JAMA, , Aug-09, Volume: 296, Issue:6, 2006
Highly potent and specific GSK-3beta inhibitors that block tau phosphorylation and decrease alpha-synuclein protein expression in a cellular model of Parkinson's disease.ChemMedChem, , Volume: 1, Issue:2, 2006
Fragmentation of Golgi apparatus of nigral neurons with alpha-synuclein-positive inclusions in patients with Parkinson's disease.Acta neuropathologica, , Volume: 112, Issue:3, 2006
Linker histone H1 binds to disease associated amyloid-like fibrils.Journal of molecular biology, , Aug-18, Volume: 361, Issue:3, 2006
LRRK2 protein is a component of Lewy bodies.Annals of neurology, , Volume: 60, Issue:5, 2006
[Amyloid-beta protein vaccine therapy for alzheimer's disease].Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, , Jun-10, Volume: 95, Issue:6, 2006
Diagnosis and treatment of Parkinson disease: molecules to medicine.The Journal of clinical investigation, , Volume: 116, Issue:7, 2006
Ventral tegmental area dopamine neurons are resistant to human mutant alpha-synuclein overexpression.Neurobiology of disease, , Volume: 23, Issue:3, 2006
Novel covalent modifications of alpha-synuclein during the recovery from proteasomal dysfunction.Biochemical and biophysical research communications, , Aug-11, Volume: 346, Issue:4, 2006
Embryonic stem cell-derived neuron models of Parkinson's disease exhibit delayed neuronal death.Journal of neurochemistry, , Volume: 98, Issue:1, 2006
Chaperone-like activities of alpha-synuclein: alpha-synuclein assists enzyme activities of esterases.Biochemical and biophysical research communications, , Aug-11, Volume: 346, Issue:4, 2006
Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients.Movement disorders : official journal of the Movement Disorder Society, , Volume: 21, Issue:10, 2006
Interaction of alpha-synuclein and dopamine metabolites in the pathogenesis of Parkinson's disease: a case for the selective vulnerability of the substantia nigra.Acta neuropathologica, , Volume: 112, Issue:2, 2006
Mutant alpha-synuclein-induced degeneration is reduced by parkin in a fly model of Parkinson's disease.Genome, , Volume: 49, Issue:5, 2006
A novel mechanism of interaction between alpha-synuclein and biological membranes.Journal of molecular biology, , Jul-07, Volume: 360, Issue:2, 2006
Is neuromelanin changed in Parkinson's disease? Investigations by magnetic spectroscopies.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 113, Issue:6, 2006
Secondary structural formation of alpha-synuclein amyloids as revealed by g-factor of solid-state circular dichroism.Biopolymers, , Oct-15, Volume: 83, Issue:3, 2006
Inhibitors of alpha-synuclein oligomerization and toxicity: a future therapeutic strategy for Parkinson's disease and related disorders.Experimental brain research, , Volume: 173, Issue:2, 2006
Regional alpha-synuclein aggregation, dopaminergic dysregulation, and the development of drug-related visual hallucinations in Parkinson's disease.The Journal of neuropsychiatry and clinical neurosciences, ,Spring, Volume: 18, Issue:2, 2006
Proteasome dysfunction in aged human alpha-synuclein transgenic mice.Neurobiology of disease, , Volume: 23, Issue:1, 2006
P25alpha immunoreactivity in multiple system atrophy and Parkinson disease.Acta neuropathologica, , Volume: 112, Issue:1, 2006
alpha-Synuclein fission yeast model: concentration-dependent aggregation without plasma membrane localization or toxicity.Journal of molecular neuroscience : MN, , Volume: 28, Issue:2, 2006
alpha-Synuclein budding yeast model: toxicity enhanced by impaired proteasome and oxidative stress.Journal of molecular neuroscience : MN, , Volume: 28, Issue:2, 2006
Heat shock proteins reduce alpha-synuclein aggregation induced by MPP+ in SK-N-SH cells.FEBS letters, , May-29, Volume: 580, Issue:13, 2006
Melanized nigral neuronal numbers in Nigerian and British individuals.Movement disorders : official journal of the Movement Disorder Society, , Volume: 21, Issue:8, 2006
Biochemical staging of synucleinopathy and amyloid deposition in dementia with Lewy bodies.Journal of neuropathology and experimental neurology, , Volume: 65, Issue:3, 2006
Anticipation of onset age in familial Parkinson's disease without SCA gene mutations.Parkinsonism & related disorders, , Volume: 12, Issue:5, 2006
Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Apr-12, Volume: 26, Issue:15, 2006
The role of chaperones in Parkinson's disease and prion diseases.Handbook of experimental pharmacology, , Issue:172, 2006
Characterization of tau pathologies in gray and white matter of Guam parkinsonism-dementia complex.Acta neuropathologica, , Volume: 111, Issue:5, 2006
Plasma membrane ion permeability induced by mutant alpha-synuclein contributes to the degeneration of neural cells.Journal of neurochemistry, , Volume: 97, Issue:4, 2006
alpha-Synuclein promoter RsaI T-to-C polymorphism and the risk of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 113, Issue:10, 2006
Intragastric proteasome inhibition induces alpha-synuclein-immunopositive aggregations in neurons in the dorsal motor nucleus of the vagus in rats.Neuroscience letters, , Jun-19, Volume: 401, Issue:1-2, 2006
Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Apr-05, Volume: 26, Issue:14, 2006
Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients.Proceedings of the National Academy of Sciences of the United States of America, , Apr-11, Volume: 103, Issue:15, 2006
[Subthalamic stimulation in a patient with multiple system atrophy: a clinicopathological report].Revue neurologique, , Volume: 162, Issue:3, 2006
Proteasomal inhibition hypersensitizes differentiated neuroblastoma cells to oxidative damage.Neuroscience letters, , May-15, Volume: 399, Issue:1-2, 2006
Identification of rotenone-induced modifications in alpha-synuclein using affinity pull-down and tandem mass spectrometry.Analytical chemistry, , Apr-01, Volume: 78, Issue:7, 2006
Alpha-synuclein facilitates the toxicity of oxidized catechol metabolites: implications for selective neurodegeneration in Parkinson's disease.FEBS letters, , Apr-03, Volume: 580, Issue:8, 2006
No alterations in alpha-synuclein gene dosage observed in sporadic Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 21, Issue:5, 2006
Gene dosage analysis of alpha-synuclein (SNCA) in patients with Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 21, Issue:5, 2006
Epidemiological, clinical, and genetic characteristics of early-onset parkinsonism.The Lancet. Neurology, , Volume: 5, Issue:4, 2006
Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases.Proceedings of the National Academy of Sciences of the United States of America, , Mar-14, Volume: 103, Issue:11, 2006
Drosophila models pioneer a new approach to drug discovery for Parkinson's disease.Drug discovery today, , Volume: 11, Issue:3-4, 2006
Abnormal alpha-synuclein solubility, aggregation and nitration in the frontal cortex in Pick's disease.Neuroscience letters, , May-29, Volume: 400, Issue:1-2, 2006
Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 20, Issue:3, 2006
Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease.Human molecular genetics, , Apr-01, Volume: 15, Issue:7, 2006
Expanding insights of mitochondrial dysfunction in Parkinson's disease.Nature reviews. Neuroscience, , Volume: 7, Issue:3, 2006
Reactive macrophages increase oxidative stress and alpha-synuclein nitration during death of dopaminergic neuronal cells in co-culture: relevance to Parkinson's disease.Neurochemical research, , Volume: 31, Issue:1, 2006
The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 113, Issue:10, 2006
6-Hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation.The Journal of biological chemistry, , Apr-07, Volume: 281, Issue:14, 2006
[The wild-type alpha-synuclein over-expression to induce the protein aberrant aggregation of alpha-synuclein in HEK293 cells in vitro].Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, , Volume: 23, Issue:1, 2006
Binding of alpha-synuclein affects the lipid packing in bilayers of small vesicles.The Journal of biological chemistry, , Apr-07, Volume: 281, Issue:14, 2006
Pathology of the sympathetic nervous system corresponding to the decreased cardiac uptake in 123I-metaiodobenzylguanidine (MIBG) scintigraphy in a patient with Parkinson disease.Journal of the neurological sciences, , Apr-15, Volume: 243, Issue:1-2, 2006
Biochemical and pathological characterization of Lrrk2.Annals of neurology, , Volume: 59, Issue:2, 2006
Dopamine transporter-mediated cytotoxicity of 6-hydroxydopamine in vitro depends on expression of mutant alpha-synucleins related to Parkinson's disease.Neurochemistry international, , Volume: 48, Issue:5, 2006
The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein.Journal of molecular biology, , Mar-03, Volume: 356, Issue:4, 2006
Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Jan-04, Volume: 26, Issue:1, 2006
Positive immunoreactivity for vesicular monoamine transporter 2 in Lewy bodies and Lewy neurites in substantia nigra.Neuroscience letters, , Apr-03, Volume: 396, Issue:3, 2006
Evidence for novel loci for late-onset Parkinson's disease in a genetic isolate from the Netherlands.Human genetics, , Volume: 119, Issue:1-2, 2006
Prolyl-isomerase Pin1 accumulates in lewy bodies of parkinson disease and facilitates formation of alpha-synuclein inclusions.The Journal of biological chemistry, , Feb-17, Volume: 281, Issue:7, 2006
Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease.Annals of neurology, , Volume: 59, Issue:2, 2006
NMR mapping of copper binding sites in alpha-synuclein.Biochimica et biophysica acta, , Volume: 1764, Issue:1, 2006
Dequalinium-induced protofibril formation of alpha-synuclein.The Journal of biological chemistry, , Feb-10, Volume: 281, Issue:6, 2006
Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology.Neuroscience letters, , Mar-20, Volume: 396, Issue:1, 2006
Nurr1 in Parkinson's disease and related disorders.The Journal of comparative neurology, , Jan-20, Volume: 494, Issue:3, 2006
Secondary structure of alpha-synuclein oligomers: characterization by raman and atomic force microscopy.Journal of molecular biology, , Jan-06, Volume: 355, Issue:1, 2006
[Parkinson's disease dementia and Lewy body dementia].Psychologie & neuropsychiatrie du vieillissement, , Volume: 4 Spec No 1, 2006
Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans.The Journal of biological chemistry, , Jan-06, Volume: 281, Issue:1, 2006
Association of alpha-synuclein Rep1 polymorphism and Parkinson's disease: influence of Rep1 on age at onset.Movement disorders : official journal of the Movement Disorder Society, , Volume: 21, Issue:4, 2006
Positron emission tomography changes in PARK1 mutation.Movement disorders : official journal of the Movement Disorder Society, , Volume: 21, Issue:1, 2006
Analysis of the polymorphic prion protein gene codon 129 in idiopathic Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 113, Issue:3, 2006
Protein denaturation and aggregation: Cellular responses to denatured and aggregated proteins.Annals of the New York Academy of Sciences, , Volume: 1066, 2005
[Pathogenesis of Parkinson's disease: a common pathway between alpha-synuclein and parkin and the mechanism of Lewy bodies formation].Rinsho shinkeigaku = Clinical neurology, , Volume: 45, Issue:11, 2005
[Pathogenesis of Parkinson's disease: implications from familial Parkinson's disease].Rinsho shinkeigaku = Clinical neurology, , Volume: 45, Issue:11, 2005
Genetic mouse models of parkinsonism: strengths and limitations.NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 2, Issue:3, 2005
Marmoset monkey models of Parkinson's disease: which model, when and why?Brain research bulletin, , Dec-30, Volume: 68, Issue:3, 2005
Neuroscientists put gene therapy into reverse.Nature, , Nov-24, Volume: 438, Issue:7067, 2005
How genetics research in Parkinson's disease is enhancing understanding of the common idiopathic forms of the disease.Current opinion in neurology, , Volume: 18, Issue:6, 2005
Snaring the function of alpha-synuclein.Cell, , Nov-04, Volume: 123, Issue:3, 2005
Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein.Molecular and cellular biology, , Volume: 25, Issue:22, 2005
Metal ions and oxidative protein modification in neurological disease.Annali dell'Istituto superiore di sanita, , Volume: 41, Issue:2, 2005
Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity.Human molecular genetics, , Dec-15, Volume: 14, Issue:24, 2005
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.The Journal of biological chemistry, , Dec-30, Volume: 280, Issue:52, 2005
A possible role for humoral immunity in the pathogenesis of Parkinson's disease.Brain : a journal of neurology, , Volume: 128, Issue:Pt 11, 2005
The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy.British journal of pharmacology, , Volume: 146, Issue:8, 2005
Genetics of Parkinson's disease.Minerva medica, , Volume: 96, Issue:3, 2005
Characterization of oligomeric intermediates in alpha-synuclein fibrillation: FRET studies of Y125W/Y133F/Y136F alpha-synuclein.Journal of molecular biology, , Oct-21, Volume: 353, Issue:2, 2005
Molecular genetic pathways in Parkinson's disease: a review.Clinical science (London, England : 1979), , Volume: 109, Issue:4, 2005
Comparison of structure and dynamics of micelle-bound human alpha-synuclein and Parkinson disease variants.The Journal of biological chemistry, , Dec-30, Volume: 280, Issue:52, 2005
Amyloid fibril formation of alpha-synuclein is accelerated by preformed amyloid seeds of other proteins: implications for the mechanism of transmissible conformational diseases.The Journal of biological chemistry, , Nov-18, Volume: 280, Issue:46, 2005
Effect of metals on herbicides-alpha-synuclein association: a possible factor in neurodegenerative disease studied by capillary electrophoresis.Electrophoresis, , Volume: 26, Issue:17, 2005
Evidence of oxidative stress in the neocortex in incidental Lewy body disease.Journal of neuropathology and experimental neurology, , Volume: 64, Issue:9, 2005
Molecular pathogenesis of Parkinson's disease.Human molecular genetics, , Sep-15, Volume: 14, Issue:18, 2005
Localization of alpha-synuclein to identified fibers and synapses in the normal mouse brain.Neuroscience, , Volume: 135, Issue:3, 2005
Nosology of Parkinson's disease: looking for the way out of a quagmire.Neuron, , Aug-18, Volume: 47, Issue:4, 2005
Alpha-synuclein dysfunction in Lewy body diseases.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
How to diagnose dementia with Lewy bodies: state of the art.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
Parkinson's disease: a broken nosology.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20 Suppl 12, 2005
Engineered alpha-synuclein prevents wild type and familial Parkin variant fibril formation.Biochemical and biophysical research communications, , Sep-23, Volume: 335, Issue:2, 2005
Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease.Journal of molecular biology, , Sep-02, Volume: 351, Issue:5, 2005
Staging of sporadic Parkinson disease-related alpha-synuclein pathology: inter- and intra-rater reliability.Journal of neuropathology and experimental neurology, , Volume: 64, Issue:7, 2005
Agrin binds alpha-synuclein and modulates alpha-synuclein fibrillation.Glycobiology, , Volume: 15, Issue:12, 2005
Haploinsufficiency for trkB and trkC receptors induces cell loss and accumulation of alpha-synuclein in the substantia nigra.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 19, Issue:12, 2005
Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20, Issue:11, 2005
Genetics of Parkinson's disease.Annals of medicine, , Volume: 37, Issue:2, 2005
A combinatorial code for the interaction of alpha-synuclein with membranes.The Journal of biological chemistry, , Sep-09, Volume: 280, Issue:36, 2005
A comparison of degeneration in motor thalamus and cortex between progressive supranuclear palsy and Parkinson's disease.Brain : a journal of neurology, , Volume: 128, Issue:Pt 10, 2005
Silver stainings distinguish Lewy bodies and glial cytoplasmic inclusions: comparison between Gallyas-Braak and Campbell-Switzer methods.Acta neuropathologica, , Volume: 110, Issue:3, 2005
Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease.Brain : a journal of neurology, , Volume: 128, Issue:Pt 11, 2005
Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA).Journal of neuropathology and experimental neurology, , Volume: 64, Issue:6, 2005
Sticking it to Parkinson's disease.Science of aging knowledge environment : SAGE KE, , Jun-22, Volume: 2005, Issue:25, 2005
Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20, Issue:9, 2005
Altered alpha-synuclein homeostasis causing Parkinson's disease: the potential roles of dardarin.Trends in neurosciences, , Volume: 28, Issue:8, 2005
Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease.Neuron, , Jun-16, Volume: 46, Issue:6, 2005
The biochemistry of Parkinson's disease.Annual review of biochemistry, , Volume: 74, 2005
Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 19, Issue:10, 2005
Antiapoptotic property of human alpha-synuclein in neuronal cell lines is associated with the inhibition of caspase-3 but not caspase-9 activity.Journal of neurochemistry, , Volume: 93, Issue:6, 2005
DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein.Journal of neurochemistry, , Volume: 93, Issue:6, 2005
Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein.Biochemistry, , May-31, Volume: 44, Issue:21, 2005
Skin and platelet alpha-synuclein as peripheral biomarkers of Parkinson's disease.Neuroscience letters, , Jun-24, Volume: 381, Issue:3, 2005
Common anti-apoptotic roles of parkin and alpha-synuclein in human dopaminergic cells.Biochemical and biophysical research communications, , Jun-24, Volume: 332, Issue:1, 2005
Alpha-synuclein and Parkinson's disease: implications from the screening of more than 1,900 patients.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20, Issue:9, 2005
Controversy: is Parkinson's disease a single disease entity? Yes.Parkinsonism & related disorders, , Volume: 11 Suppl 1, 2005
Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases.The Journal of biological chemistry, , Jul-01, Volume: 280, Issue:26, 2005
Sins of synuclein.Science of aging knowledge environment : SAGE KE, , Apr-20, Volume: 2005, Issue:16, 2005
A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease.The Journal of biological chemistry, , Jun-17, Volume: 280, Issue:24, 2005
Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease.Nature neuroscience, , Volume: 8, Issue:5, 2005
Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations.The Journal of biological chemistry, , Jun-03, Volume: 280, Issue:22, 2005
Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 19, Issue:6, 2005
The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis.Human molecular genetics, , May-01, Volume: 14, Issue:9, 2005
Metallothionein-mediated neuroprotection in genetically engineered mouse models of Parkinson's disease.Brain research. Molecular brain research, , Mar-24, Volume: 134, Issue:1, 2005
Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson's disease?Brain research. Molecular brain research, , Mar-24, Volume: 134, Issue:1, 2005
Whole-mount analysis reveals normal numbers of dopaminergic neurons following misexpression of alpha-Synuclein in Drosophila.Genesis (New York, N.Y. : 2000), , Volume: 41, Issue:4, 2005
Multiple regions of alpha-synuclein are associated with Parkinson's disease.Annals of neurology, , Volume: 57, Issue:4, 2005
A case of late onset sporadic Parkinson's disease with an A53T mutation in alpha-synuclein.Journal of neurology, neurosurgery, and psychiatry, , Volume: 76, Issue:4, 2005
Structural characterization of copper(II) binding to alpha-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , Mar-22, Volume: 102, Issue:12, 2005
Parkin gene therapy for alpha-synucleinopathy: a rat model of Parkinson's disease.Human gene therapy, , Volume: 16, Issue:2, 2005
Gene dosage and pathogenesis of Parkinson's disease.Trends in molecular medicine, , Volume: 11, Issue:3, 2005
Mitochondrial associated metabolic proteins are selectively oxidized in A30P alpha-synuclein transgenic mice--a model of familial Parkinson's disease.Neurobiology of disease, , Volume: 18, Issue:3, 2005
Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein.Experimental neurology, , Volume: 192, Issue:2, 2005
Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA).Journal of neuropathology and experimental neurology, , Volume: 64, Issue:2, 2005
Interaction of alpha-synuclein and tau genotypes in Parkinson's disease.Annals of neurology, , Volume: 57, Issue:3, 2005
Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-23, Volume: 25, Issue:8, 2005
Alpha-synuclein mRNA expression in sporadic Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20, Issue:5, 2005
Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains.The Journal of biological chemistry, , Apr-29, Volume: 280, Issue:17, 2005
Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations.Proceedings of the National Academy of Sciences of the United States of America, , Feb-08, Volume: 102, Issue:6, 2005
Methionine oxidation, alpha-synuclein and Parkinson's disease.Biochimica et biophysica acta, , Jan-17, Volume: 1703, Issue:2, 2005
Pro-apoptotic protein glyceraldehyde-3-phosphate dehydrogenase promotes the formation of Lewy body-like inclusions.The European journal of neuroscience, , Volume: 21, Issue:2, 2005
Regulation of alpha-synuclein expression by poly (ADP ribose) polymerase-1 (PARP-1) binding to the NACP-Rep1 polymorphic site upstream of the SNCA gene.American journal of human genetics, , Volume: 76, Issue:3, 2005
Australian data and meta-analysis lend support for alpha-synuclein (NACP-Rep1) as a risk factor for Parkinson's disease.Neuroscience letters, , Feb-28, Volume: 375, Issue:2, 2005
Failure to find alpha-synuclein gene dosage changes in 190 patients with familial Parkinson disease.Archives of neurology, , Volume: 62, Issue:1, 2005
Ubiquitin-proteasome system and Parkinson's diseases.Experimental neurology, , Volume: 191 Suppl 1, 2005
Ubiquitination of alpha-synuclein.Biochemistry, , Jan-11, Volume: 44, Issue:1, 2005
The role of alpha-synuclein gene multiplications in early-onset Parkinson's disease and dementia with Lewy bodies.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 112, Issue:9, 2005
Metal-catalyzed oxidation of alpha-synuclein: helping to define the relationship between oligomers, protofibrils, and filaments.The Journal of biological chemistry, , Mar-11, Volume: 280, Issue:10, 2005
Exacerbated synucleinopathy in mice expressing A53T SNCA on a Snca null background.Neurobiology of aging, , Volume: 26, Issue:1, 2005
Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila.The Journal of biological chemistry, , Jan-28, Volume: 280, Issue:4, 2005
Genetic testing in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 20, Issue:1, 2005
Influence of different promoters on the expression pattern of mutated human alpha-synuclein in transgenic mice.Neuro-degenerative diseases, , Volume: 1, Issue:6, 2004
Genetics of Parkinson disease.NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 1, Issue:2, 2004
Pathological proteins in Parkinson's disease: focus on the proteasome.Journal of molecular neuroscience : MN, , Volume: 24, Issue:3, 2004
New aspects of genetic contributions to Parkinson's disease.Journal of molecular neuroscience : MN, , Volume: 24, Issue:3, 2004
alpha-Synuclein filaments bind the transcriptional regulator HMGB-1.Neuroreport, , Dec-22, Volume: 15, Issue:18, 2004
Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , Dec-14, Volume: 101, Issue:50, 2004
Targeting alpha-synuclein in Parkinson's disease.Chemistry & biology, , Volume: 11, Issue:11, 2004
Alpha-synuclein structures from fluorescence energy-transfer kinetics: implications for the role of the protein in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , Nov-23, Volume: 101, Issue:47, 2004
Limbic neuropathology in idiopathic Parkinson's disease with concomitant dementia.Folia neuropathologica, , Volume: 42, Issue:3, 2004
A single amino acid substitution differentiates Hsp70-dependent effects on alpha-synuclein degradation and toxicity.Biochemical and biophysical research communications, , Dec-03, Volume: 325, Issue:1, 2004
Absence of heparan sulfate proteoglycans in Lewy bodies and Lewy neurites in Parkinson's disease brains.Journal of Alzheimer's disease : JAD, , Volume: 6, Issue:5, 2004
Synucleins and their relationship to Parkinson's disease.Cell and tissue research, , Volume: 318, Issue:1, 2004
DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation.PLoS biology, , Volume: 2, Issue:11, 2004
Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein.FEBS letters, , Oct-22, Volume: 576, Issue:3, 2004
Lewy body-related alpha-synucleinopathy in the aged human brain.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 111, Issue:10-11, 2004
Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease.Neurobiology of disease, , Volume: 17, Issue:2, 2004
alpha-Synuclein expression levels do not significantly affect proteasome function and expression in mice and stably transfected PC12 cell lines.The Journal of biological chemistry, , Dec-17, Volume: 279, Issue:51, 2004
[Analysis of alpha-synuclein and its significance].Nihon rinsho. Japanese journal of clinical medicine, , Volume: 62, Issue:9, 2004
[Molecular biology for familial Parkinson's disease].Nihon rinsho. Japanese journal of clinical medicine, , Volume: 62, Issue:9, 2004
Parkinson's disease: alpha-synuclein build-up explained.The Lancet. Neurology, , Volume: 3, Issue:10, 2004
alpha-Synuclein promoter confers susceptibility to Parkinson's disease.Annals of neurology, , Volume: 56, Issue:4, 2004
Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease.Journal of neurochemistry, , Volume: 91, Issue:2, 2004
Lack of alpha-synuclein does not alter apoptosis of neonatal catecholaminergic neurons.The European journal of neuroscience, , Volume: 20, Issue:7, 2004
Beta-synuclein gene alterations in dementia with Lewy bodies.Neurology, , Sep-14, Volume: 63, Issue:5, 2004
Protective effect of TAT-delivered alpha-synuclein: relevance of the C-terminal domain and involvement of HSP70.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 18, Issue:14, 2004
Parkin-positive autosomal recessive juvenile Parkinsonism with alpha-synuclein-positive inclusions.Neurology, , Aug-24, Volume: 63, Issue:4, 2004
Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Aug-18, Volume: 24, Issue:33, 2004
SNCA multiplication is not a common cause of Parkinson disease or dementia with Lewy bodies.Neurology, , Aug-10, Volume: 63, Issue:3, 2004
[The alpha-synuclein gene microsatellite polymorphism and late-onset sporadic Parkinson's disease susceptibility].Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, , Volume: 21, Issue:4, 2004
Alpha-synuclein induces apoptosis by altered expression in human peripheral lymphocyte in Parkinson's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 18, Issue:13, 2004
Unraveling the pathogenesis of Parkinson's disease--the contribution of monogenic forms.Cellular and molecular life sciences : CMLS, , Volume: 61, Issue:14, 2004
Genes, proteins, and neurotoxins involved in Parkinson's disease.Progress in neurobiology, , Volume: 73, Issue:3, 2004
Does cellular iron dysregulation play a causative role in Parkinson's disease?Ageing research reviews, , Volume: 3, Issue:3, 2004
UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's disease.Journal of neurochemistry, , Volume: 90, Issue:2, 2004
Could a loss of alpha-synuclein function put dopaminergic neurons at risk?Journal of neurochemistry, , Volume: 89, Issue:6, 2004
ABri peptide associated with familial British dementia forms annular and ring-like protofibrillar structures.Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, , Volume: 11, Issue:1, 2004
Alpha-synuclein aggregation.Protein and peptide letters, , Volume: 11, Issue:3, 2004
Alpha-synuclein and the pathogenesis of Parkinson's disease.Protein and peptide letters, , Volume: 11, Issue:3, 2004
Proteomic approach to studying Parkinson's disease.Molecular neurobiology, , Volume: 29, Issue:3, 2004
A strategy for designing inhibitors of alpha-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 18, Issue:11, 2004
Alpha-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication.Neurology, , May-25, Volume: 62, Issue:10, 2004
Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation.Experimental neurology, , Volume: 187, Issue:2, 2004
alpha-Synuclein regulation of the dopaminergic transporter: a possible role in the pathogenesis of Parkinson's disease.FEBS letters, , May-07, Volume: 565, Issue:1-3, 2004
Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease.Journal of molecular neuroscience : MN, , Volume: 23, Issue:1-2, 2004
Alpha-synuclein, Parkinson's disease, and Alzheimer's disease.Parkinsonism & related disorders, , Volume: 10 Suppl 1, 2004
NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation.The EMBO journal, , May-19, Volume: 23, Issue:10, 2004
Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein.Biochemistry, , Apr-27, Volume: 43, Issue:16, 2004
Alpha-synuclein: normal function and role in neurodegenerative diseases.Current topics in developmental biology, , Volume: 60, 2004
Parkin counteracts symptoms in a Drosophila model of Parkinson's disease.BMC neuroscience, , Apr-16, Volume: 5, 2004
Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , Apr-13, Volume: 101, Issue:15, 2004
Dopamine and L-dopa disaggregate amyloid fibrils: implications for Parkinson's and Alzheimer's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 18, Issue:9, 2004
Does alpha-synuclein modulate dopaminergic synaptic content and tone at the synapse?FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 18, Issue:6, 2004
Alpha-synuclein and Parkinson's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 18, Issue:6, 2004
Structural determinants of PLD2 inhibition by alpha-synuclein.Journal of molecular biology, , Apr-02, Volume: 337, Issue:4, 2004
alpha-Synuclein A53T substitution associated with Parkinson disease also marks the divergence of Old World and New World primates.Genomics, , Volume: 83, Issue:4, 2004
Beta-synuclein regulates Akt activity in neuronal cells. A possible mechanism for neuroprotection in Parkinson's disease.The Journal of biological chemistry, , May-28, Volume: 279, Issue:22, 2004
Commentary on "Alpha-synuclein and mitochondria: a tangled skein".Experimental neurology, , Volume: 186, Issue:2, 2004
Tissue transglutaminase catalyzes the formation of alpha-synuclein crosslinks in Parkinson's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 18, Issue:7, 2004
Chasing genes in Alzheimer's and Parkinson's disease.Human genetics, , Volume: 114, Issue:5, 2004
Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons.Journal of cell science, , Mar-01, Volume: 117, Issue:Pt 7, 2004
Pael-R is accumulated in Lewy bodies of Parkinson's disease.Annals of neurology, , Volume: 55, Issue:3, 2004
Parkin and alpha-synuclein: opponent actions in the pathogenesis of Parkinson's disease.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, , Volume: 10, Issue:1, 2004
Alteration in alpha-synuclein mRNA expression in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 19, Issue:2, 2004
Parkinson's disease transgenic mitochondrial cybrids generate Lewy inclusion bodies.Journal of neurochemistry, , Volume: 88, Issue:4, 2004
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia.Annals of neurology, , Volume: 55, Issue:2, 2004
Alpha-synuclein in Parkinson's disease: light from two new angles.Annals of neurology, , Volume: 55, Issue:2, 2004
Association between cardiac denervation and parkinsonism caused by alpha-synuclein gene triplication.Brain : a journal of neurology, , Volume: 127, Issue:Pt 4, 2004
Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy.Acta neuropathologica, , Volume: 107, Issue:4, 2004
Proteasome inhibition and aggregation in Parkinson's disease: a comparative study in untransfected and transfected cells.Journal of neurochemistry, , Volume: 88, Issue:3, 2004
Alpha-synuclein haplotypes implicated in risk of Parkinson's disease.Neurology, , Jan-13, Volume: 62, Issue:1, 2004
Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective.The Journal of biological chemistry, , Feb-06, Volume: 279, Issue:6, 2004
Regulation of alpha-synuclein expression: implications for Parkinson's disease.Cold Spring Harbor symposia on quantitative biology, , Volume: 68, 2003
Degenerative axonal changes in the hippocampus and amygdala in Parkinson's disease.Folia neuropathologica, , Volume: 41, Issue:4, 2003
[Study on exons 3 and 4 of alpha-synuclein gene in Chinese familial Parkinson disease patients].Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, , Volume: 20, Issue:6, 2003
Alpha-synuclein gene triplication discovered in Parkinson's disease.The Lancet. Neurology, , Volume: 2, Issue:12, 2003
Caught in the act: alpha-synuclein is the culprit in Parkinson's disease.Neuron, , Oct-30, Volume: 40, Issue:3, 2003
Case-control study of the alpha-synuclein interacting protein gene and Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 18, Issue:11, 2003
alpha-Synuclein locus triplication causes Parkinson's disease.Science (New York, N.Y.), , Oct-31, Volume: 302, Issue:5646, 2003
Molecular pathways of neurodegeneration in Parkinson's disease.Science (New York, N.Y.), , Oct-31, Volume: 302, Issue:5646, 2003
NACP-REP1 polymorphism is not involved in Parkinson's disease: a case-control study in a population sample from southern Italy.Neuroscience letters, , Nov-13, Volume: 351, Issue:2, 2003
New insights into Parkinson's disease.Journal of neurology, , Volume: 250 Suppl 3, 2003
Aggregation of alpha-synuclein in the pathogenesis of Parkinson's disease.Journal of neurology, , Volume: 250 Suppl 3, 2003
[Lewy bodies, a misleading marker for Parkinson's disease?].Bulletin de l'Academie nationale de medecine, , Volume: 187, Issue:2, 2003
Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer's and Parkinson's diseases.Neuromolecular medicine, , Volume: 4, Issue:1-2, 2003
Challenges and complexities of alpha-synuclein toxicity: new postulates in unfolding the mystery associated with Parkinson's disease.Archives of biochemistry and biophysics, , Oct-15, Volume: 418, Issue:2, 2003
Alpha-synuclein oligomerization: a role for lipids?Trends in neurosciences, , Volume: 26, Issue:10, 2003
Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 17, Issue:13, 2003
Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains.Acta neuropathologica, , Volume: 106, Issue:6, 2003
Alpha-synuclein accumulates in Purkinje cells in Lewy body disease but not in multiple system atrophy.Journal of neuropathology and experimental neurology, , Volume: 62, Issue:8, 2003
Alpha-synuclein: between synaptic function and dysfunction.Histology and histopathology, , Volume: 18, Issue:4, 2003
A protein-chameleon: conformational plasticity of alpha-synuclein, a disordered protein involved in neurodegenerative disorders.Journal of biomolecular structure & dynamics, , Volume: 21, Issue:2, 2003
The role of alpha-synuclein in Parkinson's disease: insights from animal models.Nature reviews. Neuroscience, , Volume: 4, Issue:9, 2003
What have we learnt from CDNA microarray gene expression studies about the role of iron in MPTP induced neurodegeneration and Parkinson's disease?Journal of neural transmission. Supplementum, , Issue:65, 2003
The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins?The Lancet. Neurology, , Volume: 2, Issue:9, 2003
Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies.Human molecular genetics, , Oct-15, Volume: 12, Issue:20, 2003
Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function.The Journal of biological chemistry, , Nov-07, Volume: 278, Issue:45, 2003
Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease.Human molecular genetics, , Oct-01, Volume: 12, Issue:19, 2003
Dissociation of amyloid fibrils of alpha-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities.Proceedings of the National Academy of Sciences of the United States of America, , Aug-19, Volume: 100, Issue:17, 2003
Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro.Journal of neurochemistry, , Volume: 86, Issue:4, 2003
The association of alpha-synuclein with membranes affects bilayer structure, stability, and fibril formation.The Journal of biological chemistry, , Oct-10, Volume: 278, Issue:41, 2003
Cell cycle aberrations by alpha-synuclein over-expression and cyclin B immunoreactivity in Lewy bodies.Neurobiology of aging, , Volume: 24, Issue:5, 2003
alpha-synuclein aggregation: a link between mitochondrial defects and Parkinson's disease?Antioxidants & redox signaling, , Volume: 5, Issue:3, 2003
Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis.The American journal of pathology, , Volume: 163, Issue:2, 2003
Beta-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation: cross-talk with alpha-synuclein and implication for Parkinson's disease.The Journal of biological chemistry, , Sep-26, Volume: 278, Issue:39, 2003
Modeling CNS neurodegeneration by overexpression of disease-causing proteins using viral vectors.Trends in neurosciences, , Volume: 26, Issue:7, 2003
The cast of molecular characters in Parkinson's disease: felons, conspirators, and suspects.Annals of the New York Academy of Sciences, , Volume: 991, 2003
Alpha-synuclein pathology in Parkinson's and Alzheimer's disease brain: incidence and topographic distribution--a pilot study.Acta neuropathologica, , Volume: 106, Issue:3, 2003
Parkinson's disease: alpha-synuclein and parkin in protein aggregation and the reversal of unfolded protein stress.Methods in molecular biology (Clifton, N.J.), , Volume: 232, 2003
[Parkinson's disease: what have we learned from the genes responsible for familial forms?].Medecine sciences : M/S, , Volume: 19, Issue:5, 2003
Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease.Biochemistry, , Jul-08, Volume: 42, Issue:26, 2003
Essential tremor is not associated with alpha-synuclein gene haplotypes.Movement disorders : official journal of the Movement Disorder Society, , Volume: 18, Issue:7, 2003
Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease.Neuropharmacology, , Volume: 45, Issue:1, 2003
A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins.Journal of molecular biology, , Jun-13, Volume: 329, Issue:4, 2003
Alpha-synuclein-positive structures in association with diffuse neurofibrillary tangles with calcification.Neuropathology and applied neurobiology, , Volume: 29, Issue:3, 2003
Alpha-synuclein up-regulates expression of caveolin-1 and down-regulates extracellular signal-regulated kinase activity in B103 neuroblastoma cells: role in the pathogenesis of Parkinson's disease.Journal of neurochemistry, , Volume: 85, Issue:6, 2003
Complex interactions in Parkinson's disease: a two-phased approach.Movement disorders : official journal of the Movement Disorder Society, , Volume: 18, Issue:6, 2003
Therapeutic strategies for Parkinson's disease based on data derived from genetic research.Journal of neurology, , Volume: 250 Suppl 1, 2003
Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease.Human molecular genetics, , Jun-01, Volume: 12, Issue:11, 2003
Clinical characteristics of the alpha-synuclein mutation (G209A)-associated Parkinson's disease in comparison with other forms of familial Parkinson's disease in Greece.European journal of neurology, , Volume: 10, Issue:3, 2003
Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1.The Journal of biological chemistry, , Aug-01, Volume: 278, Issue:31, 2003
Nitration inhibits fibrillation of human alpha-synuclein in vitro by formation of soluble oligomers.FEBS letters, , May-08, Volume: 542, Issue:1-3, 2003
Differential cytotoxicity of dopamine and H2O2 in a human neuroblastoma divided cell line transfected with alpha-synuclein and its familial Parkinson's disease-linked mutants.Neuroscience letters, , May-15, Volume: 342, Issue:1-2, 2003
Colocalization of tau and alpha-synuclein epitopes in Lewy bodies.Journal of neuropathology and experimental neurology, , Volume: 62, Issue:4, 2003
Association of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathies.The Journal of biological chemistry, , Jun-27, Volume: 278, Issue:26, 2003
Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila.Neuron, , Mar-27, Volume: 37, Issue:6, 2003
Beta-synuclein inhibits formation of alpha-synuclein protofibrils: a possible therapeutic strategy against Parkinson's disease.Biochemistry, , Apr-08, Volume: 42, Issue:13, 2003
Proteolytic stress: a unifying concept for the etiopathogenesis of Parkinson's disease.Annals of neurology, , Volume: 53 Suppl 3, 2003
Enhanced oligomerization of the alpha-synuclein mutant by the Cu,Zn-superoxide dismutase and hydrogen peroxide system.Molecules and cells, , Feb-28, Volume: 15, Issue:1, 2003
Ubiquitinated inclusions and neuronal cell death.Histology and histopathology, , Volume: 18, Issue:2, 2003
Alpha-synuclein pathology affecting Bergmann glia of the cerebellum in patients with alpha-synucleinopathies.Acta neuropathologica, , Volume: 105, Issue:4, 2003
Lipid binding inhibits alpha-synuclein fibril formation.The Journal of biological chemistry, , May-09, Volume: 278, Issue:19, 2003
Familial and sporadic Parkinson's disease usually display the same clinical features.Parkinsonism & related disorders, , Volume: 9, Issue:4, 2003
Parkinson's disease-associated alpha-synuclein is a calmodulin substrate.The Journal of biological chemistry, , May-09, Volume: 278, Issue:19, 2003
Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , Mar-04, Volume: 100, Issue:5, 2003
The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease.Neuron, , Feb-20, Volume: 37, Issue:4, 2003
Residual substantia nigra neuromelanin in Parkinson's disease is cross-linked to alpha-synuclein.Neurochemistry international, , Volume: 42, Issue:7, 2003
Tissue transglutaminase-induced aggregation of alpha-synuclein: Implications for Lewy body formation in Parkinson's disease and dementia with Lewy bodies.Proceedings of the National Academy of Sciences of the United States of America, , Feb-18, Volume: 100, Issue:4, 2003
Recent advances on alpha-synuclein cell biology: functions and dysfunctions.Current molecular medicine, , Volume: 3, Issue:1, 2003
Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function.The Journal of biological chemistry, , Apr-04, Volume: 278, Issue:14, 2003
Nucleus-specific alteration of raphe neurons in human neurodegenerative disorders.Neuroreport, , Jan-20, Volume: 14, Issue:1, 2003
Polymorphisms of the alpha-synuclein promoter: expression analyses and association studies in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 110, Issue:1, 2003
Lewy bodies in Betz cells of the motor cortex in a patient with Parkinson's disease.Acta neuropathologica, , Volume: 105, Issue:2, 2003
Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis.Biochemistry, , Jan-28, Volume: 42, Issue:3, 2003
The N-terminal repeat domain of alpha-synuclein inhibits beta-sheet and amyloid fibril formation.Biochemistry, , Jan-28, Volume: 42, Issue:3, 2003
Alpha synuclein promoter and risk of Parkinson's disease: microsatellite and allelic size variability.Neuroscience letters, , Jan-09, Volume: 336, Issue:1, 2003
Haploinsufficiency at the alpha-synuclein gene underlies phenotypic severity in familial Parkinson's disease.Brain : a journal of neurology, , Volume: 126, Issue:Pt 1, 2003
Alpha-synuclein and Parkinson's disease.Advances in neurology, , Volume: 91, 2003
Cellular polyamines promote the aggregation of alpha-synuclein.The Journal of biological chemistry, , Jan-31, Volume: 278, Issue:5, 2003
Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice.Proceedings of the National Academy of Sciences of the United States of America, , Jun-25, Volume: 99, Issue:13, 2002
Genetics of Parkinson's disease and biochemical studies of implicated gene products.Current opinion in genetics & development, , Volume: 12, Issue:3, 2002
Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred.Acta neuropathologica, , Volume: 104, Issue:1, 2002
Parkinson's disease: one biochemical pathway to fit all genes?Trends in molecular medicine, , Volume: 8, Issue:5, 2002
MPP+ increases alpha-synuclein expression and ERK/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cells.Brain research, , May-10, Volume: 935, Issue:1-2, 2002
Mutant and wild-type alpha-synuclein interact with mitochondrial cytochrome C oxidase.Journal of molecular neuroscience : MN, , Volume: 18, Issue:3, 2002
Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease.Nature medicine, , Volume: 8, Issue:6, 2002
Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease.Free radical biology & medicine, , Jun-01, Volume: 32, Issue:11, 2002
The cell biology of alpha-synuclein: a sticky problem?Neuromolecular medicine, , Volume: 1, Issue:2, 2002
Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice.Experimental neurology, , Volume: 175, Issue:1, 2002
An alternatively spliced form of rodent alpha-synuclein forms intracellular inclusions in vitro: role of the carboxy-terminus in alpha-synuclein aggregation.Neuroscience letters, , May-03, Volume: 323, Issue:3, 2002
Aggregation of alpha-synuclein induced by the Cu,Zn-superoxide dismutase and hydrogen peroxide system.Free radical biology & medicine, , Mar-15, Volume: 32, Issue:6, 2002
6-Hydroxydopamine lesioning differentially affects alpha-synuclein mRNA expression in the nucleus accumbens, striatum and substantia nigra of adult rats.Neuroscience letters, , Mar-29, Volume: 322, Issue:1, 2002
Sequence conservation between mouse and human synphilin-1.Neuroscience letters, , Mar-29, Volume: 322, Issue:1, 2002
A role for alpha-synuclein in the regulation of dopamine biosynthesis.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Apr-15, Volume: 22, Issue:8, 2002
Accelerated alpha-synuclein fibrillation in crowded milieu.FEBS letters, , Mar-27, Volume: 515, Issue:1-3, 2002
Co-occurrence of Parkinson's disease with progressive supranuclear palsy.Acta neuropathologica, , Volume: 103, Issue:5, 2002
Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism.Biochemistry, , Apr-09, Volume: 41, Issue:14, 2002
Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Apr-01, Volume: 22, Issue:7, 2002
Dopaminergic cell loss induced by human A30P alpha-synuclein gene transfer to the rat substantia nigra.Human gene therapy, , Mar-20, Volume: 13, Issue:5, 2002
Molecular crowding accelerates fibrillization of alpha-synuclein: could an increase in the cytoplasmic protein concentration induce Parkinson's disease?Biochemistry, , Mar-26, Volume: 41, Issue:12, 2002
14-3-3 proteins in Lewy bodies in Parkinson disease and diffuse Lewy body disease brains.Journal of neuropathology and experimental neurology, , Volume: 61, Issue:3, 2002
Human alpha-synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine.Neuroscience letters, , Mar-08, Volume: 320, Issue:3, 2002
Iron and Parkinson's disease.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, , Volume: 8, Issue:1, 2002
Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease.Science (New York, N.Y.), , Feb-01, Volume: 295, Issue:5556, 2002
Overexpression of human alpha-synuclein causes dopamine neuron death in primary human mesencephalic culture.Brain research, , Feb-01, Volume: 926, Issue:1-2, 2002
Heparin and other glycosaminoglycans stimulate the formation of amyloid fibrils from alpha-synuclein in vitro.Biochemistry, , Feb-05, Volume: 41, Issue:5, 2002
Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein.Journal of molecular biology, , Jan-25, Volume: 315, Issue:4, 2002
Recent advances in the genetics and pathogenesis of Parkinson disease.Neurology, , Jan-22, Volume: 58, Issue:2, 2002
No male predominance in alpha-synuclein Parkinson's disease but the affected female fetus might be less viable.Journal of neurology, neurosurgery, and psychiatry, , Volume: 72, Issue:2, 2002
Alzheimer's and Parkinson's disease--overlapping or synergistic pathologies?Trends in molecular medicine, , Volume: 8, Issue:1, 2002
The reaction of nitric oxide with 6-hydroxydopamine: implications for Parkinson's disease.Free radical biology & medicine, , Jan-15, Volume: 32, Issue:2, 2002
Effects of pharmacological agents upon a transgenic model of Parkinson's disease in Drosophila melanogaster.The Journal of pharmacology and experimental therapeutics, , Volume: 300, Issue:1, 2002
Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alpha-synuclein.The Journal of biological chemistry, , Feb-22, Volume: 277, Issue:8, 2002
[Genetics and environmental factors of Parkinson disease].Revue neurologique, , Volume: 158 Spec no 1, 2002
Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons.Neuron, , Dec-19, Volume: 36, Issue:6, 2002
Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein.Nature reviews. Neuroscience, , Volume: 3, Issue:12, 2002
Nicotinic receptors in the putamen of patients with dementia with Lewy bodies and Parkinson's disease: relation to changes in alpha-synuclein expression.Neuroscience letters, , Dec-25, Volume: 335, Issue:2, 2002
[Gene diagnosis of Alzheimer's disease and Parkinson's disease].Rinsho byori. The Japanese journal of clinical pathology, , Volume: 50, Issue:10, 2002
Platelet alpha- and gamma-synucleins in Parkinson's disease and normal control subjects.Journal of Alzheimer's disease : JAD, , Volume: 4, Issue:4, 2002
Alpha-synuclein and presynaptic function: implications for Parkinson's disease.Neuromolecular medicine, , Volume: 2, Issue:2, 2002
Conformational behavior of human alpha-synuclein is modulated by familial Parkinson's disease point mutations A30P and A53T.Neurotoxicology, , Volume: 23, Issue:4-5, 2002
Synergistic effects of pesticides and metals on the fibrillation of alpha-synuclein: implications for Parkinson's disease.Neurotoxicology, , Volume: 23, Issue:4-5, 2002
Parkinson's disease and related synucleinopathies are a new class of nervous system amyloidoses.Neurotoxicology, , Volume: 23, Issue:4-5, 2002
Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease.Brain research, , Nov-22, Volume: 956, Issue:1, 2002
Association of Lewy bodies and glial cytoplasmic inclusions in the brain of Parkinson's disease.Acta neuropathologica, , Volume: 104, Issue:5, 2002
The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.Cell, , Oct-18, Volume: 111, Issue:2, 2002
Mechanistic approaches to Parkinson's disease pathogenesis.Brain pathology (Zurich, Switzerland), , Volume: 12, Issue:4, 2002
Alpha-synuclein lowers p53-dependent apoptotic response of neuronal cells. Abolishment by 6-hydroxydopamine and implication for Parkinson's disease.The Journal of biological chemistry, , Dec-27, Volume: 277, Issue:52, 2002
Clinical correlates of selective pathology in the amygdala of patients with Parkinson's disease.Brain : a journal of neurology, , Volume: 125, Issue:Pt 11, 2002
Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.Proceedings of the National Academy of Sciences of the United States of America, , Oct-29, Volume: 99, Issue:22, 2002
Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils.Journal of molecular biology, , Oct-04, Volume: 322, Issue:5, 2002
Overexpression of Parkinson's disease-associated alpha-synucleinA53T by recombinant adeno-associated virus in mice does not increase the vulnerability of dopaminergic neurons to MPTP.Journal of neurobiology, , Volume: 53, Issue:1, 2002
A novel polymorphic triplet repeat in intron five of the alpha-synuclein gene: no evidence of expansion or allelic association with idiopathic Parkinson's disease in the Irish.Neuroreport, , Sep-16, Volume: 13, Issue:13, 2002
Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease.Human molecular genetics, , Oct-01, Volume: 11, Issue:20, 2002
Genetics of Parkinson's disease and biochemical studies of implicated gene products.Current opinion in cell biology, , Volume: 14, Issue:5, 2002
Molecular genetic analysis of the alpha-synuclein and the parkin gene in Parkinson's disease in Finland.European journal of neurology, , Volume: 9, Issue:5, 2002
Nonselenium glutathione peroxidase in human brain : elevated levels in Parkinson's disease and dementia with lewy bodies.The American journal of pathology, , Volume: 161, Issue:3, 2002
Survival duration of Parkinson's disease patients living in Greece who carry the G209A alpha-synuclein mutation.Movement disorders : official journal of the Movement Disorder Society, , Volume: 17, Issue:4, 2002
Genetics of parkinsonism.Movement disorders : official journal of the Movement Disorder Society, , Volume: 17, Issue:4, 2002
Meta-analysis of alpha synuclein/ NACP polymorphism in Parkinson's disease in Japan.Journal of neurology, neurosurgery, and psychiatry, , Volume: 73, Issue:3, 2002
An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Aug-15, Volume: 22, Issue:16, 2002
Clusterin/apolipoprotein J is associated with cortical Lewy bodies: immunohistochemical study in cases with alpha-synucleinopathies.Acta neuropathologica, , Volume: 104, Issue:3, 2002
Structure/function of alpha-synuclein in health and disease: rational development of animal models for Parkinson's and related diseases.Journal of neurochemistry, , Volume: 82, Issue:3, 2002
Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line.The Journal of biological chemistry, , Oct-11, Volume: 277, Issue:41, 2002
[Parkin, alpha-synuclein and other molecular aspects of Parkinson's disease].Journal de la Societe de biologie, , Volume: 196, Issue:1, 2002
Neurodegenerative disease: amyloid pores from pathogenic mutations.Nature, , Jul-18, Volume: 418, Issue:6895, 2002
alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , Aug-06, Volume: 99, Issue:16, 2002
Structural transformation and aggregation of human alpha-synuclein in trifluoroethanol: non-amyloid component sequence is essential and beta-sheet formation is prerequisite to aggregation.Biopolymers, , Aug-05, Volume: 64, Issue:4, 2002
Production of reactive oxygen species from aggregating proteins implicated in Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases.Current topics in medicinal chemistry, , Volume: 1, Issue:6, 2001
The cellular pathology of Parkinson's disease.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 21, Issue:4, 2001
Active, phosphorylation-dependent mitogen-activated protein kinase (MAPK/ERK), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and p38 kinase expression in Parkinson's disease and Dementia with Lewy bodies.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 108, Issue:12, 2001
Effect of allelic variation at the NACP-Rep1 repeat upstream of the alpha-synuclein gene (SNCA) on transcription in a cell culture luciferase reporter system.Human molecular genetics, , Dec-15, Volume: 10, Issue:26, 2001
Analysis of the coding and the 5' flanking regions of the alpha-synuclein gene in patients with Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 16, Issue:6, 2001
Clinical features of parkinsonian patients with the alpha-synuclein (G209A) mutation.Movement disorders : official journal of the Movement Disorder Society, , Volume: 16, Issue:6, 2001
Lack of binding observed between human alpha-synuclein and Bcl-2 protein family.Neuroscience letters, , Volume: 316, Issue:2, 2001
Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Dec-15, Volume: 21, Issue:24, 2001
alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome.FEBS letters, , Nov-30, Volume: 509, Issue:1, 2001
Sympathetic neurocirculatory failure in Parkinson disease: Evidence for an etiologic role of alpha-synuclein.Annals of internal medicine, , Dec-04, Volume: 135, Issue:11, 2001
alpha-synuclein and cytosolic dopamine: stabilizing a bad situation.Nature medicine, , Volume: 7, Issue:12, 2001
alpha-Synuclein and parkin: coming together of pieces in puzzle of Parkinson's disease.Lancet (London, England), , Nov-10, Volume: 358, Issue:9293, 2001
Alpha-synuclein in familial Alzheimer disease: epitope mapping parallels dementia with Lewy bodies and Parkinson disease.Archives of neurology, , Volume: 58, Issue:11, 2001
Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct.Science (New York, N.Y.), , Nov-09, Volume: 294, Issue:5545, 2001
Genetics of Parkinson's disease.Journal of neurology, , Volume: 248, Issue:10, 2001
Widespread occurrence of argyrophilic glial inclusions in Parkinson's disease.Neuropathology and applied neurobiology, , Volume: 27, Issue:5, 2001
Brain iron pathways and their relevance to Parkinson's disease.Journal of neurochemistry, , Volume: 79, Issue:2, 2001
Cortical Lewy body pathology in the diagnosis of dementia.Acta neuropathologica, , Volume: 102, Issue:4, 2001
Alpha-synuclein has an altered conformation and shows a tight intermolecular interaction with ubiquitin in Lewy bodies.Acta neuropathologica, , Volume: 102, Issue:4, 2001
The G209A mutation in the alpha-synuclein gene in Brazilian families with Parkinson's disease.Arquivos de neuro-psiquiatria, , Volume: 59, Issue:3-B, 2001
Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease.Nature medicine, , Volume: 7, Issue:10, 2001
Residual structure and dynamics in Parkinson's disease-associated mutants of alpha-synuclein.The Journal of biological chemistry, , Dec-07, Volume: 276, Issue:49, 2001
Co-association of parkin and alpha-synuclein.Neuroreport, , Sep-17, Volume: 12, Issue:13, 2001
Evaluation of the gamma-synuclein gene in German Parkinson's disease patients.Neuroscience letters, , Sep-14, Volume: 310, Issue:2-3, 2001
beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America, , Oct-09, Volume: 98, Issue:21, 2001
Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein.Biochemistry, , Sep-25, Volume: 40, Issue:38, 2001
Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure.The Journal of biological chemistry, , Nov-23, Volume: 276, Issue:47, 2001
alpha-Synuclein gene haplotypes are associated with Parkinson's disease.Human molecular genetics, , Aug-15, Volume: 10, Issue:17, 2001
Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells.Journal of neurochemistry, , Volume: 78, Issue:4, 2001
Alpha synuclein aggregation: is it the toxic gain of function responsible for neurodegeneration in Parkinson's disease?Mechanisms of ageing and development, , Sep-30, Volume: 122, Issue:14, 2001
Decreased platelet glutamate uptake and genetic risk factors in patients with Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, , Volume: 22, Issue:1, 2001
Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease.FEBS letters, , Jul-06, Volume: 500, Issue:3, 2001
Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons.Neuroscience, , Volume: 104, Issue:3, 2001
Alpha-synuclein and neurodegenerative diseases.Nature reviews. Neuroscience, , Volume: 2, Issue:7, 2001
Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease.Science (New York, N.Y.), , Jul-13, Volume: 293, Issue:5528, 2001
Genetics of Parkinsonism: a review.Annals of human genetics, , Volume: 65, Issue:Pt 2, 2001
Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.Biochemistry, , Jul-03, Volume: 40, Issue:26, 2001
[Alpha-synucleinopathies].Neurologia (Barcelona, Spain), , Volume: 16, Issue:4, 2001
Abnormal patterns of microtubule-associated protein-2 (MAP-2) immunolabeling in neuronal nuclei and Lewy bodies in Parkinson's disease substantia nigra brain tissues.Neuroscience letters, , Jun-29, Volume: 306, Issue:3, 2001
Mouse models of alpha-synucleinopathy and Lewy pathology. Alpha-synuclein expression in transgenic mice.Advances in experimental medicine and biology, , Volume: 487, 2001
Alpha-synuclein. Axonal transport, ligand interaction and neurodegeneration.Advances in experimental medicine and biology, , Volume: 487, 2001
Parkinson's disease and other alpha-synucleinopathies.Clinical chemistry and laboratory medicine, , Volume: 39, Issue:4, 2001
alpha-Synuclein implicated in Parkinson's disease catalyses the formation of hydrogen peroxide in vitro.Free radical biology & medicine, , May-15, Volume: 30, Issue:10, 2001
Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice.Journal of neurochemistry, , Volume: 77, Issue:4, 2001
Parkinson's disease is not associated with the combined alpha-synuclein/apolipoprotein E susceptibility genotype.Annals of neurology, , Volume: 49, Issue:5, 2001
Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations.Journal of neurochemistry, , Volume: 77, Issue:3, 2001
Fate of midbrain dopaminergic neurons controlled by the engrailed genes.The Journal of neuroscience : the official journal of the Society for Neuroscience, , May-01, Volume: 21, Issue:9, 2001
Clinical phenotype in patients with alpha-synuclein Parkinson's disease living in Greece in comparison with patients with sporadic Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry, , Volume: 70, Issue:5, 2001
Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis.Human molecular genetics, , Apr-15, Volume: 10, Issue:9, 2001
alpha-synuclein immunopositive Parkinson's disease-related inclusion bodies in lower brain stem nuclei.Acta neuropathologica, , Volume: 101, Issue:3, 2001
Conformational properties of alpha-synuclein in its free and lipid-associated states.Journal of molecular biology, , Apr-06, Volume: 307, Issue:4, 2001
alpha-Synuclein forms a complex with transcription factor Elk-1.Journal of neurochemistry, , Volume: 77, Issue:1, 2001
Mutations in the alpha-synuclein gene in Parkinson's disease among Indians.Acta neurologica Scandinavica, , Volume: 103, Issue:2, 2001
Genetic studies in Parkinson's disease with an alpha-synuclein/NACP gene polymorphism in Japan.Neuroscience letters, , Mar-09, Volume: 300, Issue:2, 2001
Synucleinopathies: clinical and pathological implications.Archives of neurology, , Volume: 58, Issue:2, 2001
The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease.Journal of neurochemistry, , Volume: 76, Issue:1, 2001
Genetics of movement disorders: an abbreviated overview.Stereotactic and functional neurosurgery, , Volume: 77, Issue:1-4, 2001
Alpha-synuclein and Parkinson's disease.Cellular and molecular life sciences : CMLS, , Volume: 57, Issue:13-14, 2000
Crosslinking of alpha-synuclein by advanced glycation endproducts--an early pathophysiological step in Lewy body formation?Journal of chemical neuroanatomy, , Volume: 20, Issue:3-4, 2000
Alpha-synuclein is not a requisite component of synaptic boutons in the adult human central nervous system.Journal of chemical neuroanatomy, , Volume: 20, Issue:3-4, 2000
Structural changes in alpha-synuclein affect its chaperone-like activity in vitro.Protein science : a publication of the Protein Society, , Volume: 9, Issue:12, 2000
Depression in alpha-synucleinopathies: prevalence, pathophysiology and treatment.Journal of neural transmission. Supplementum, , Issue:60, 2000
Importance of familial Parkinson's disease and parkinsonism to the understanding of nigral degeneration in sporadic Parkinson's disease.Journal of neural transmission. Supplementum, , Issue:60, 2000
Accelerated oligomerization by Parkinson's disease linked alpha-synuclein mutants.Annals of the New York Academy of Sciences, , Volume: 920, 2000
Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein.Annals of the New York Academy of Sciences, , Volume: 920, 2000
Genetics of Parkinson's disease.Annals of the New York Academy of Sciences, , Volume: 920, 2000
The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.Annals of the New York Academy of Sciences, , Volume: 920, 2000
Mouse models of alpha-synucleinopathy and Lewy pathology.Experimental gerontology, , Volume: 35, Issue:9-10, 2000
Linkage exclusion in French families with probable Parkinson' s disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 15, Issue:6, 2000
[Synucleins--to have or not to have].Genetika, , Volume: 36, Issue:11, 2000
Monoclonal antibodies against Epstein-Barr virus cross-react with alpha-synuclein in human brain.Neurology, , Nov-14, Volume: 55, Issue:9, 2000
In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodies.Experimental neurology, , Volume: 166, Issue:2, 2000
Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein.Journal of neurochemistry, , Volume: 75, Issue:6, 2000
Activated microglial cells and complement factors are unrelated to cortical Lewy bodies.Acta neuropathologica, , Volume: 100, Issue:6, 2000
[The mechanism of Lewy body formation in Parkinson's disease].Nihon rinsho. Japanese journal of clinical medicine, , Volume: 58, Issue:10, 2000
[Molecular pathogenesis of familial Parkinson's disease].Nihon rinsho. Japanese journal of clinical medicine, , Volume: 58, Issue:10, 2000
Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity.Human molecular genetics, , Nov-01, Volume: 9, Issue:18, 2000
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions.Science (New York, N.Y.), , Nov-03, Volume: 290, Issue:5493, 2000
Characterisation of isolated alpha-synuclein filaments from substantia nigra of Parkinson's disease brain.Neuroscience letters, , Oct-06, Volume: 292, Issue:2, 2000
Progress in the clinical and molecular genetics of familial parkinsonism.Neurogenetics, , Volume: 2, Issue:4, 2000
Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein.Biochemistry, , Sep-05, Volume: 39, Issue:35, 2000
Induction of neuronal death by alpha-synuclein.The European journal of neuroscience, , Volume: 12, Issue:8, 2000
Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease.Acta neuropathologica, , Volume: 100, Issue:3, 2000
Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Sep-01, Volume: 20, Issue:17, 2000
Oxidative stress and genetics in the pathogenesis of Parkinson's disease.Neurobiology of disease, , Volume: 7, Issue:4, 2000
Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.The Journal of biological chemistry, , Nov-03, Volume: 275, Issue:44, 2000
Parkinson's disease-associated alpha-synuclein is more fibrillogenic than beta- and gamma-synuclein and cannot cross-seed its homologs.The Journal of biological chemistry, , Nov-03, Volume: 275, Issue:44, 2000
The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Aug-15, Volume: 20, Issue:16, 2000
Late-onset neurodegenerative diseases--the role of protein insolubility.Journal of anatomy, , Volume: 196 ( Pt 4), 2000
Properties of NACP/alpha-synuclein and its role in Alzheimer's disease.Biochimica et biophysica acta, , Jul-26, Volume: 1502, Issue:1, 2000
Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?Nature cell biology, , Volume: 2, Issue:7, 2000
Accumulation of insoluble alpha-synuclein in dementia with Lewy bodies.Neurobiology of disease, , Volume: 7, Issue:3, 2000
Full length alpha-synuclein is present in cerebrospinal fluid from Parkinson's disease and normal subjects.Neuroscience letters, , Jun-16, Volume: 287, Issue:1, 2000
Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells.Brain research, , Jun-02, Volume: 866, Issue:1-2, 2000
Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease.Neurology, , May-23, Volume: 54, Issue:10, 2000
Wild-type but not Parkinson's disease-related ala-53 --> Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli.The Journal of biological chemistry, , Aug-04, Volume: 275, Issue:31, 2000
Involvement of alpha-synuclein in Parkinson's disease and other neurodegenerative disorders.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 107, Issue:1, 2000
Alpha-synuclein and Parkinson's disease: selective neurodegenerative effect of alpha-synuclein fragment on dopaminergic neurons in vitro and in vivo.Annals of neurology, , Volume: 47, Issue:5, 2000
Parkinson's disease: affection of brain stem nuclei controlling premotor and motor neurons of the somatomotor system.Acta neuropathologica, , Volume: 99, Issue:5, 2000
Alpha-synuclein and the Parkinson's disease-related mutant Ala53Thr-alpha-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cells.Neuroscience letters, , May-12, Volume: 285, Issue:2, 2000
The alpha-synuclein gene and Parkinson disease in a Chinese population.Archives of neurology, , Volume: 57, Issue:4, 2000
Synphilin-1 is present in Lewy bodies in Parkinson's disease.Annals of neurology, , Volume: 47, Issue:4, 2000
A Drosophila model of Parkinson's disease.Nature, , Mar-23, Volume: 404, Issue:6776, 2000
Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations.The Journal of biological chemistry, , Mar-24, Volume: 275, Issue:12, 2000
Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid.Biochemistry, , Mar-14, Volume: 39, Issue:10, 2000
A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease.Journal of neuroscience research, , Feb-15, Volume: 59, Issue:4, 2000
Expression of alpha-synuclein, parkin, and ubiquitin carboxy-terminal hydrolase L1 mRNA in human brain: genes associated with familial Parkinson's disease.Annals of neurology, , Volume: 47, Issue:2, 2000
NACP/alpha-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson's disease brains.Acta neuropathologica, , Volume: 99, Issue:1, 2000
Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy.Proceedings of the National Academy of Sciences of the United States of America, , Jan-18, Volume: 97, Issue:2, 2000
Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein.The Journal of biological chemistry, , Jan-07, Volume: 275, Issue:1, 2000
[Parkinson's disease, dementia with Lewy bodies, multiple system atrophy and alpha-synuclein].Rinsho shinkeigaku = Clinical neurology, , Volume: 39, Issue:12, 1999
Search for the PARK3 founder haplotype in a large cohort of patients with Parkinson's disease from northern Germany.Annals of human genetics, , Volume: 63, Issue:Pt 4, 1999
[A 73-year-old woman with familial Parkinson's disease].No to shinkei = Brain and nerve, , Volume: 51, Issue:12, 1999
The expression of alpha-, beta-, and gamma-synucleins in olfactory mucosa from patients with and without neurodegenerative diseases.Experimental neurology, , Volume: 160, Issue:2, 1999
PET studies of parkinsonism associated with mutation in the alpha-synuclein gene.Neurology, , Dec-10, Volume: 53, Issue:9, 1999
Increased expression of rat synuclein in the substantia nigra pars compacta identified by mRNA differential display in a model of developmental target injury.Journal of neurochemistry, , Volume: 73, Issue:6, 1999
Absence of G209A and G88C mutations in the alpha-synuclein gene of Parkinson's disease in a Chinese population.European neurology, , Volume: 42, Issue:4, 1999
Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein.Proceedings of the National Academy of Sciences of the United States of America, , Nov-09, Volume: 96, Issue:23, 1999
Alpha-synuclein immunoreactive Lewy bodies and Lewy neurites in Parkinson's disease are detectable by an advanced silver-staining technique.Acta neuropathologica, , Volume: 98, Issue:5, 1999
The alpha-synuclein gene is not a major risk factor in familial Parkinson disease.Neurogenetics, , Volume: 2, Issue:3, 1999
Cellular co-localization of phosphorylated tau- and NACP/alpha-synuclein-epitopes in lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies.Brain research, , Oct-02, Volume: 843, Issue:1-2, 1999
Synucleins in synaptic plasticity and neurodegenerative disorders.Journal of neuroscience research, , Oct-01, Volume: 58, Issue:1, 1999
Reduced expression of the G209A alpha-synuclein allele in familial Parkinsonism.Annals of neurology, , Volume: 46, Issue:3, 1999
[Genetics of Parkinson disease].La Revue de medecine interne, , Volume: 20, Issue:8, 1999
Alpha-synuclein accumulates in Lewy bodies in Parkinson's disease and dementia with Lewy bodies but not in Alzheimer's disease beta-amyloid plaque cores.Neuroscience letters, , May-14, Volume: 266, Issue:3, 1999
Filamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and alpha-synucleinopathies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences, , Jun-29, Volume: 354, Issue:1386, 1999
No pathogenic mutations in the beta-synuclein gene in Parkinson's disease.Neuroscience letters, , Jul-09, Volume: 269, Issue:2, 1999
[alpha-Synuclein and familial Parkinson's disease].No to shinkei = Brain and nerve, , Volume: 51, Issue:6, 1999
Genetic analysis of families with Parkinson disease that carry the Ala53Thr mutation in the gene encoding alpha-synuclein.American journal of human genetics, , Volume: 65, Issue:2, 1999
alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease.The Journal of biological chemistry, , Jul-09, Volume: 274, Issue:28, 1999
Copper(II)-induced self-oligomerization of alpha-synuclein.The Biochemical journal, , Jun-15, Volume: 340 ( Pt 3), 1999
Genetics of Parkinson's disease.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 53, Issue:3, 1999
Alpha-synuclein expression in substantia nigra and cortex in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 14, Issue:3, 1999
Numerous and widespread alpha-synuclein-negative Lewy bodies in an asymptomatic patient.Acta neuropathologica, , Volume: 97, Issue:5, 1999
Extensive axonal Lewy neurites in Parkinson's disease: a novel pathological feature revealed by alpha-synuclein immunocytochemistry.Neuroscience letters, , Apr-09, Volume: 265, Issue:1, 1999
Increased susceptibility to sporadic Parkinson's disease by a certain combined alpha-synuclein/apolipoprotein E genotype.Annals of neurology, , Volume: 45, Issue:5, 1999
Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions.Nature genetics, , Volume: 22, Issue:1, 1999
Synoretin--A new protein belonging to the synuclein family.Molecular and cellular neurosciences, , Volume: 13, Issue:2, 1999
Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation.The Journal of biological chemistry, , Apr-02, Volume: 274, Issue:14, 1999
Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro.The Journal of biological chemistry, , Mar-19, Volume: 274, Issue:12, 1999
Mutated alpha-synuclein gene in two Greek kindreds with familial PD: incomplete penetrance?Neurology, , Volume: 52, Issue:3, 1999
No mutation of G209A in the alpha-synuclein gene in sporadic Parkinson's disease among Taiwan Chinese.European neurology, , Volume: 41, Issue:2, 1999
Alpha-synuclein and Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society, , Volume: 14, Issue:1, 1999
[Parkinson disease: monogenic forms and genetic susceptibility factors].Pathologie-biologie, , Volume: 46, Issue:9, 1998
Novel alpha-synuclein-immunoreactive proteins in brain samples from the Contursi kindred, Parkinson's, and Alzheimer's disease.Experimental neurology, , Volume: 154, Issue:2, 1998
Mutation screening in exons 3 and 4 of alpha-synuclein in sporadic Parkinson's and sporadic and familial dementia with Lewy bodies cases.Neuroreport, , Dec-01, Volume: 9, Issue:17, 1998
Degenerative terminals of the perforant pathway are human alpha-synuclein-immunoreactive in the hippocampus of patients with diffuse Lewy body disease.Neuroscience letters, , Dec-18, Volume: 258, Issue:2, 1998
The G209A mutation in the alpha-synuclein gene is not detected in familial cases of Parkinson disease in non-Greek and/or Italian populations.Archives of neurology, , Volume: 55, Issue:12, 1998
Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments.FEBS letters, , Nov-27, Volume: 440, Issue:1-2, 1998
Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease.FEBS letters, , Nov-27, Volume: 440, Issue:1-2, 1998
Alpha synuclein is present in Lewy bodies in sporadic Parkinson's disease.Molecular psychiatry, , Volume: 3, Issue:6, 1998
Mutation, sequence analysis, and association studies of alpha-synuclein in Parkinson's disease.Neurology, , Volume: 51, Issue:6, 1998
Lack of mutation G209A in the alpha-synuclein gene in French patients with familial and sporadic Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry, , Volume: 65, Issue:6, 1998
Accumulation of alpha-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy.Acta neuropathologica, , Volume: 96, Issue:5, 1998
Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.Nature medicine, , Volume: 4, Issue:11, 1998
Genetic dissection of familial Parkinson's disease.Molecular medicine today, , Volume: 4, Issue:10, 1998
Abnormal distribution of the non-Abeta component of Alzheimer's disease amyloid precursor/alpha-synuclein in Lewy body disease as revealed by proteinase K and formic acid pretreatment.Laboratory investigation; a journal of technical methods and pathology, , Volume: 78, Issue:9, 1998
Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.The Journal of biological chemistry, , Oct-09, Volume: 273, Issue:41, 1998
The native form of alpha-synuclein is not found in the cerebrospinal fluid of patients with Parkinson's disease or normal controls.Neuroscience letters, , Aug-28, Volume: 253, Issue:1, 1998
The synuclein family.Genome research, , Volume: 8, Issue:9, 1998
Autosomal dominant Parkinson's disease and alpha-synuclein.Annals of neurology, , Volume: 44, Issue:3 Suppl 1, 1998
Genetics of Parkinson's disease.Annals of neurology, , Volume: 44, Issue:3 Suppl 1, 1998
Lewy body in neurodegeneration with brain iron accumulation type 1 is immunoreactive for alpha-synuclein.Neurology, , Volume: 51, Issue:3, 1998
Mutation in the alpha-synuclein gene and sporadic Parkinson's disease, Alzheimer's disease, and dementia with lewy bodies.Experimental neurology, , Volume: 153, Issue:1, 1998
The role of the alpha-synuclein gene mutation in patients with sporadic Parkinson's disease in the United Kingdom.Journal of neurology, neurosurgery, and psychiatry, , Volume: 65, Issue:3, 1998
Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies.Neuroscience letters, , Jul-31, Volume: 251, Issue:3, 1998
Multiple-system atrophy: a new alpha-synuclein disease?Lancet (London, England), , Aug-15, Volume: 352, Issue:9127, 1998
The alpha-synuclein Ala53Thr mutation is not a common cause of familial Parkinson's disease: a study of 230 European cases. European Consortium on Genetic Susceptibility in Parkinson's Disease.Annals of neurology, , Volume: 44, Issue:2, 1998
Alpha synuclein in neurodegenerative disorders: murderer or accomplice?Nature medicine, , Volume: 4, Issue:7, 1998
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The cDNA cloning and ontogeny of mouse alpha-synuclein.Neuroreport, , Apr-20, Volume: 9, Issue:6, 1998
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[no title available]eNeuro, , Volume: 7, Issue:4
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Protective Effects of Ursodeoxycholic Acid Against Oxidative Stress and Neuroinflammation Through Mitogen-Activated Protein Kinases Pathway in MPTP-Induced Parkinson Disease.Clinical neuropharmacology, , Volume: 45, Issue:6
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α-Synuclein-Dependent Calcium Entry Underlies Differential Sensitivity of Cultured SN and VTA Dopaminergic Neurons to a Parkinsonian Neurotoxin.eNeuro, , Volume: 4, Issue:6
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Neuroprotective effects of indole-3-carbinol on the rotenone rat model of Parkinson's disease: Impact of the SIRT1-AMPK signaling pathway.Toxicology and applied pharmacology, , 01-15, Volume: 435, 2022
Xanthotoxin modulates oxidative stress, inflammation, and MAPK signaling in a rotenone-induced Parkinson's disease model.Life sciences, , Dec-01, Volume: 310, 2022
In Vivo Diagnosis of Synucleinopathies: A Comparative Study of Skin Biopsy and RT-QuIC.Neurology, , 05-18, Volume: 96, Issue:20, 2021
An extended release GLP-1 analogue increases α-synuclein accumulation in a mouse model of prodromal Parkinson's disease.Experimental neurology, , Volume: 341, 2021
Metals associated neurodegeneration in Parkinson's disease: Insight to physiological, pathological mechanisms and management.Neuroscience letters, , 05-14, Volume: 753, 2021
Autophagy-dependent removal of α-synuclein: a novel mechanism of GM1 ganglioside neuroprotection against Parkinson's disease.Acta pharmacologica Sinica, , Volume: 42, Issue:4, 2021
Administration of quercetin improves mitochondria quality control and protects the neurons in 6-OHDA-lesioned Parkinson's disease models.Aging, , 04-20, Volume: 13, Issue:8, 2021
Parkinson-like early autonomic dysfunction induced by vagal application of DOPAL in rats.CNS neuroscience & therapeutics, , Volume: 27, Issue:5, 2021
Noscapine Prevents Rotenone-Induced Neurotoxicity: Involvement of Oxidative Stress, Neuroinflammation and Autophagy Pathways.Molecules (Basel, Switzerland), , Jul-30, Volume: 26, Issue:15, 2021
Benzo(a)pyrene exposure in utero exacerbates Parkinson's Disease (PD)-like α-synucleinopathy in A53T human alpha-synuclein transgenic mice.Toxicology and applied pharmacology, , 09-15, Volume: 427, 2021
Protective effect of plastrum testudinis extract on dopaminergic neurons in a Parkinson's disease model through DNMT1 nuclear translocation and SNCA's methylation.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 141, 2021
Cycad Genotoxin Methylazoxymethanol Disrupts the Brain Ubiquitin-Proteasome Pathway, Tau and α-Synuclein, as Reported in ALS-PDC.Journal of neuropathology and experimental neurology, , 02-22, Volume: 80, Issue:3, 2021
4E-BP1 Protects Neurons from Misfolded Protein Stress and Parkinson's Disease Toxicity by Inducing the Mitochondrial Unfolded Protein Response.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 11-04, Volume: 40, Issue:45, 2020
Neuroprotective effects of Bacopa monnieri in Parkinson's disease model.Metabolic brain disease, , Volume: 35, Issue:3, 2020
Potential therapeutic role of fibroblast growth factor 21 in neurodegeneration: Evidence for ameliorating parkinsonism via silent information regulator 2 homolog 1 and implication for gene therapy.Neuropharmacology, , 12-15, Volume: 181, 2020
Nose to brain delivery of rotigotine loaded chitosan nanoparticles in human SH-SY5Y neuroblastoma cells and animal model of Parkinson's disease.International journal of pharmaceutics, , Apr-15, Volume: 579, 2020
Induction of Autophagy by Vasicinone Protects Neural Cells from Mitochondrial Dysfunction and Attenuates Paraquat-Mediated Parkinson's Disease Associated α-Synuclein Levels.Nutrients, , Jun-07, Volume: 12, Issue:6, 2020
Regular Aerobic Exercise-Alleviated Dysregulation of CAMKIIα Carbonylation to Mitigate Parkinsonism via Homeostasis of Apoptosis With Autophagy.Journal of neuropathology and experimental neurology, , 01-01, Volume: 79, Issue:1, 2020
FTY720 Improves Behavior, Increases Brain Derived Neurotrophic Factor Levels and Reduces α-Synuclein Pathology in Parkinsonian GM2+/- Mice.Neuroscience, , 07-15, Volume: 411, 2019
TLR4 deficiency has a protective effect in the MPTP/probenecid mouse model of Parkinson's disease.Acta pharmacologica Sinica, , Volume: 40, Issue:12, 2019
Identification of miRNA-7 as a regulator of brain-derived neurotrophic factor/α-synuclein axis in atrazine-induced Parkinson's disease by peripheral blood and brain microRNA profiling.Chemosphere, , Volume: 233, 2019
Methyl jasmonate abrogates rotenone-induced parkinsonian-like symptoms through inhibition of oxidative stress, release of pro-inflammatory cytokines, and down-regulation of immnopositive cells of NF-κB and α-synuclein expressions in mice.Neurotoxicology, , Volume: 74, 2019
Administration of resveratrol improved Parkinson's disease-like phenotype by suppressing apoptosis of neurons via modulating the MALAT1/miR-129/SNCA signaling pathway.Journal of cellular biochemistry, , Volume: 120, Issue:4, 2019
NLRP3 inflammasome pathway is involved in olfactory bulb pathological alteration induced by MPTP.Acta pharmacologica Sinica, , Volume: 40, Issue:8, 2019
Dopaminergic neuron injury in Parkinson's disease is mitigated by interfering lncRNA SNHG14 expression to regulate the miR-133b/ α-synuclein pathway.Aging, , 11-04, Volume: 11, Issue:21, 2019
Acrolein-mediated alpha-synuclein pathology involvement in the early post-injury pathogenesis of mild blast-induced Parkinsonian neurodegeneration.Molecular and cellular neurosciences, , Volume: 98, 2019
Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein.Science signaling, , 03-12, Volume: 12, Issue:572, 2019
Hinokitiol Offers Neuroprotection Against 6-OHDA-Induced Toxicity in SH-SY5Y Neuroblastoma Cells by Downregulating mRNA Expression of MAO/α-Synuclein/LRRK2/PARK7/PINK1/PTEN Genes.Neurotoxicity research, , Volume: 35, Issue:4, 2019
The use of nonhuman primate models to understand processes in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 125, Issue:3, 2018
Taurine protects dopaminergic neurons in a mouse Parkinson's disease model through inhibition of microglial M1 polarization.Cell death & disease, , 04-01, Volume: 9, Issue:4, 2018
Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein.Nature communications, , 02-26, Volume: 9, Issue:1, 2018
Glycyrrhizic Acid Alleviates 6-Hydroxydopamine and Corticosterone-Induced Neurotoxicity in SH-SY5Y Cells Through Modulating Autophagy.Neurochemical research, , Volume: 43, Issue:10, 2018
Environmental neurotoxicant manganese regulates exosome-mediated extracellular miRNAs in cell culture model of Parkinson's disease: Relevance to α-synuclein misfolding in metal neurotoxicity.Neurotoxicology, , Volume: 64, 2018
NLRP3 inflammasome activation in the thymus of MPTP-induced Parkinsonian mouse model.Toxicology letters, , May-15, Volume: 288, 2018
DL‑3‑n‑butylphthalide reduces microglial activation in lipopolysaccharide‑induced Parkinson's disease model mice.Molecular medicine reports, , Volume: 17, Issue:3, 2018
Alpha-synuclein aggregation, Ubiquitin proteasome system impairment, and L-Dopa response in zinc-induced Parkinsonism: resemblance to sporadic Parkinson's disease.Molecular and cellular biochemistry, , Volume: 444, Issue:1-2, 2018
Increased Oxidative Stress Exacerbates α-Synuclein Aggregation In Vivo.Journal of neuropathology and experimental neurology, , 06-01, Volume: 77, Issue:6, 2018
Fingolimod (FTY720) is not protective in the subacute MPTP mouse model of Parkinson's disease and does not lead to a sustainable increase of brain-derived neurotrophic factor.Journal of neurochemistry, , Volume: 147, Issue:5, 2018
Decreased expression of serum- and glucocorticoid-inducible kinase 1 (SGK1) promotes alpha-synuclein increase related with down-regulation of dopaminergic cell in the Substantia Nigra of chronic MPTP-induced Parkinsonism mice and in SH-SY5Y cells.Gene, , Jun-30, Volume: 661, 2018
Immunomorphological Changes in the Olfactory Bulbs of Rats after Intranasal Administration of Rotenone.Bulletin of experimental biology and medicine, , Volume: 164, Issue:2, 2017
Novel animal model defines genetic contributions for neuron-to-neuron transfer of α-synuclein.Scientific reports, , 08-08, Volume: 7, Issue:1, 2017
Mitochondrial division inhibitor-1 is neuroprotective in the A53T-α-synuclein rat model of Parkinson's disease.Scientific reports, , 08-08, Volume: 7, Issue:1, 2017
Pramipexole induced place preference after L-dopa therapy and nigral dopaminergic loss: linking behavior to transcriptional modifications.Psychopharmacology, , Volume: 234, Issue:1, 2017
Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson's disease.Experimental neurology, , Volume: 295, 2017
Rifampicin pre-treatment inhibits the toxicity of rotenone-induced PC12 cells by enhancing sumoylation modification of α-synuclein.Biochemical and biophysical research communications, , 03-25, Volume: 485, Issue:1, 2017
S-nitrosylation of UCHL1 induces its structural instability and promotes α-synuclein aggregation.Scientific reports, , 03-16, Volume: 7, 2017
Resveratrol alleviates MPTP-induced motor impairments and pathological changes by autophagic degradation of α-synuclein via SIRT1-deacetylated LC3.Molecular nutrition & food research, , Volume: 60, Issue:10, 2016
Apocyanin, NADPH oxidase inhibitor prevents lipopolysaccharide induced α-synuclein aggregation and ameliorates motor function deficits in rats: Possible role of biochemical and inflammatory alterations.Behavioural brain research, , Jan-01, Volume: 296, 2016
Baicalein inhibits α-synuclein oligomer formation and prevents progression of α-synuclein accumulation in a rotenone mouse model of Parkinson's disease.Biochimica et biophysica acta, , Volume: 1862, Issue:10, 2016
Melanin and neuromelanin binding of drugs and chemicals: toxicological implications.Archives of toxicology, , Volume: 90, Issue:8, 2016
Protective effects and mechanisms of Ndfipl on SH-SY5Y cell apoptosis in an in vitro Parkinson's disease model.Genetics and molecular research : GMR, , Apr-25, Volume: 15, Issue:2, 2016
Neuroprotective Effects of A Standardized Flavonoid Extract of Safflower Against Neurotoxin-Induced Cellular and Animal Models of Parkinson's Disease.Scientific reports, , Feb-24, Volume: 6, 2016
Targeted Overexpression of α-Synuclein by rAAV2/1 Vectors Induces Progressive Nigrostriatal Degeneration and Increases Vulnerability to MPTP in Mouse.PloS one, , Volume: 10, Issue:6, 2015
The Progressive BSSG Rat Model of Parkinson's: Recapitulating Multiple Key Features of the Human Disease.PloS one, , Volume: 10, Issue:10, 2015
Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation.Molecular and cellular biology, , Volume: 35, Issue:16, 2015
Linking microtubules to Parkinson's disease: the case of parkin.Biochemical Society transactions, , Volume: 43, Issue:2, 2015
Fractalkine over expression suppresses α-synuclein-mediated neurodegeneration.Molecular therapy : the journal of the American Society of Gene Therapy, , Volume: 23, Issue:1, 2015
Proteasome subunit and opioid receptor gene expression down-regulation induced by paraquat and maneb in human neuroblastoma SH-SY5Y cells.Environmental toxicology and pharmacology, , Volume: 40, Issue:3, 2015
Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice.Antioxidants & redox signaling, , Aug-20, Volume: 23, Issue:6, 2015
Panax ginseng is neuroprotective in a novel progressive model of Parkinson's disease.Experimental gerontology, , Volume: 50, 2014
Cell-based assays for Parkinson's disease using differentiated human LUHMES cells.Acta pharmacologica Sinica, , Volume: 35, Issue:7, 2014
Cardiac sympathetic denervation in 6-OHDA-treated nonhuman primates.PloS one, , Volume: 9, Issue:8, 2014
Analysis of dopaminergic neuronal dysfunction in genetic and toxin-induced models of Parkinson's disease in Drosophila.Journal of neurochemistry, , Volume: 131, Issue:3, 2014
MicroRNA-7 protects against 1-methyl-4-phenylpyridinium-induced cell death by targeting RelA.The Journal of neuroscience : the official journal of the Society for Neuroscience, , Sep-17, Volume: 34, Issue:38, 2014
Geraniol attenuates α-synuclein expression and neuromuscular impairment through increase dopamine content in MPTP intoxicated mice by dose dependent manner.Biochemical and biophysical research communications, , Nov-01, Volume: 440, Issue:4, 2013
Nasal inoculation with α-synuclein aggregates evokes rigidity, locomotor deficits and immunity to such misfolded species as well as dopamine.Behavioural brain research, , Apr-15, Volume: 243, 2013
Reprint of: revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease-resemblance to the effect of amphetamine drugs of abuse.Free radical biology & medicine, , Volume: 62, 2013
Therapeutic effects of rapamycin on MPTP-induced Parkinsonism in mice.Neurochemical research, , Volume: 38, Issue:1, 2013
[Neurotoxicity of pesticides: its relationship with neurodegenerative diseases].Medecine sciences : M/S, , Volume: 29, Issue:3, 2013
G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome.Annals of neurology, , Volume: 73, Issue:4, 2013
Olfaction in three genetic and two MPTP-induced Parkinson's disease mouse models.PloS one, , Volume: 8, Issue:10, 2013
Agrochemicals, α-synuclein, and Parkinson's disease.Molecular neurobiology, , Volume: 47, Issue:2, 2013
In vivo electrophysiology of nigral and thalamic neurons in alpha-synuclein-overexpressing mice highlights differences from toxin-based models of parkinsonism.Journal of neurophysiology, , Volume: 110, Issue:12, 2013
Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice.Scientific reports, , Volume: 2, 2012
Animal models of the non-motor features of Parkinson's disease.Neurobiology of disease, , Volume: 46, Issue:3, 2012
Do α-synuclein vector injections provide a better model of Parkinson's disease than the classic 6-hydroxydopamine model?Experimental neurology, , Volume: 237, Issue:1, 2012
A spirulina-enhanced diet provides neuroprotection in an α-synuclein model of Parkinson's disease.PloS one, , Volume: 7, Issue:9, 2012
Development and characterisation of a novel rat model of Parkinson's disease induced by sequential intranigral administration of AAV-α-synuclein and the pesticide, rotenone.Neuroscience, , Feb-17, Volume: 203, 2012
Comparison of the behavioural and histological characteristics of the 6-OHDA and α-synuclein rat models of Parkinson's disease.Experimental neurology, , Volume: 235, Issue:1, 2012
Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson's disease.Journal of neurochemistry, , Volume: 122, Issue:2, 2012
Cerebrospinal fluid-based kinetic biomarkers of axonal transport in monitoring neurodegeneration.The Journal of clinical investigation, , Volume: 122, Issue:9, 2012
Long-term polarization of microglia upon α-synuclein overexpression in nonhuman primates.Neuroscience, , Apr-19, Volume: 208, 2012
Animal models of Parkinson's disease.The FEBS journal, , Volume: 279, Issue:7, 2012
Evaluation of TorsinA as a target for Parkinson disease therapy in mouse models.PloS one, , Volume: 7, Issue:11, 2012
Increased iron levels correlate with the selective nigral dopaminergic neuron degeneration in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996), , Volume: 118, Issue:3, 2011
Progressive loss of dopaminergic neurons induced by unilateral rotenone infusion into the medial forebrain bundle.Brain research, , Nov-11, Volume: 1360, 2010
dl-3-n-Butylphthalide prevents oxidative damage and reduces mitochondrial dysfunction in an MPP(+)-induced cellular model of Parkinson's disease.Neuroscience letters, , May-14, Volume: 475, Issue:2, 2010
The MPTP-lesioned non-human primate models of Parkinson's disease. Past, present, and future.Progress in brain research, , Volume: 184, 2010
Valproic acid is neuroprotective in the rotenone rat model of Parkinson's disease: involvement of alpha-synuclein.Neurotoxicity research, , Volume: 17, Issue:2, 2010
From manganism to manganese-induced parkinsonism: a conceptual model based on the evolution of exposure.Neuromolecular medicine, , Volume: 11, Issue:4, 2009
Alpha-synuclein and its role in metal binding: relevance to Parkinson's disease.Journal of neuroscience research, , Feb-15, Volume: 86, Issue:3, 2008
Alpha-synuclein, pesticides, and Parkinson disease: a case-control study.Neurology, , Apr-15, Volume: 70, Issue:16 Pt 2, 2008
Striatal 19S Rpt6 deficit is related to alpha-synuclein accumulation in MPTP-treated mice.Biochemical and biophysical research communications, , Nov-14, Volume: 376, Issue:2, 2008
Critical appraisal of brain pathology staging related to presymptomatic and symptomatic cases of sporadic Parkinson's disease.Journal of neural transmission. Supplementum, , Issue:70, 2006
A short overview on the role of alpha-synuclein and proteasome in experimental models of Parkinson's disease.Journal of neural transmission. Supplementum, , Issue:70, 2006
Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys.Annals of neurology, , Volume: 60, Issue:2, 2006
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Diagnostic Utility of Cerebrospinal Fluid α-Synuclein in Creutzfeldt-Jakob Disease: A Systematic Review and Meta-Analysis.Journal of Alzheimer's disease : JAD, , Volume: 89, Issue:2, 2022
Structural and Functional Insights into α-Synuclein Fibril Polymorphism.Biomolecules, , 09-28, Volume: 11, Issue:10, 2021
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Parkinson's Disease: A Prionopathy?International journal of molecular sciences, , Jul-27, Volume: 22, Issue:15, 2021
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Experimental models of prion-like protein propagation.Neuropathology : official journal of the Japanese Society of Neuropathology, , Volume: 40, Issue:5, 2020
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Expanding spectrum of prion diseases.Emerging topics in life sciences, , 09-08, Volume: 4, Issue:2, 2020
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[The Propagation Hypothesis of Prion-like Protein Agregates in Neurodegenerative Diseases].Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 71, Issue:11, 2019
Million-fold sensitivity enhancement in proteopathic seed amplification assays for biospecimens by Hofmeister ion comparisons.Proceedings of the National Academy of Sciences of the United States of America, , 11-12, Volume: 116, Issue:46, 2019
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Safety/Toxicity (450)
| Article | Year |
|---|
Citrus Flavonoid Hesperetin Inhibits α-Synuclein Fibrillogenesis, Disrupts Mature Fibrils, and Reduces Their Cytotoxicity: In Vitro and In Vivo Studies.
Journal of agricultural and food chemistry, , Nov-01, Volume: 71, Issue:43 | 2023 |
Uncovering the Role of Natural and Synthetic Small Molecules in Counteracting the Burden of α-Synuclein Aggregates and Related Toxicity in Different Models of Parkinson's Disease.
International journal of molecular sciences, , Aug-29, Volume: 24, Issue:17 | 2023 |
Structure specific neuro-toxicity of α-synuclein oligomer.
International journal of biological macromolecules, , Dec-31, Volume: 253, Issue:Pt 1 | 2023 |
Elucidation of Secondary Structure and Toxicity of α-Synuclein Oligomers and Fibrils Grown in the Presence of Phosphatidylcholine and Phosphatidylserine.
ACS chemical neuroscience, , 09-06, Volume: 14, Issue:17 | 2023 |
Coumarin-chalcone hybrid LM-021 and indole derivative NC009-1 targeting inflammation and oxidative stress to protect BE(2)-M17 cells against α-synuclein toxicity.
Aging, , 08-11, Volume: 15, Issue:16 | 2023 |
Implications of In Vitro Multi-Serine Phosphorylation of Alpha-Synuclein in Aggregation and Cytotoxicity.
ACS chemical neuroscience, , 09-06, Volume: 14, Issue:17 | 2023 |
GM1 oligosaccharide efficacy against α-synuclein aggregation and toxicity in vitro.
Biochimica et biophysica acta. Molecular and cell biology of lipids, , Volume: 1868, Issue:9 | 2023 |
Unsaturated fatty acids uniquely alter aggregation rate of α-synuclein and insulin and change the secondary structure and toxicity of amyloid aggregates formed in their presence.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 37, Issue:7 | 2023 |
Phosphorylation of α-synuclein at T64 results in distinct oligomers and exerts toxicity in models of Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America, , 06-06, Volume: 120, Issue:23 | 2023 |
Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity.
PLoS genetics, , Volume: 19, Issue:5 | 2023 |
Retinoic Acid Prevents α-Synuclein Preformed Fibrils-Induced Toxicity via Inhibiting STAT1-PARP1 Signaling.
Molecular neurobiology, , Volume: 60, Issue:8 | 2023 |
Dopamine-Induced Oligomers of α-Synuclein Inhibit Amyloid Fibril Growth and Show No Toxicity.
ACS chemical neuroscience, , 06-07, Volume: 14, Issue:11 | 2023 |
Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage.
Nature communications, , 04-06, Volume: 14, Issue:1 | 2023 |
Neuronal identity defines α-synuclein and tau toxicity.
Neuron, , 05-17, Volume: 111, Issue:10 | 2023 |
Mesenchymal stem-cell-derived microvesicles ameliorate MPTP-induced neurotoxicity in mice: a role of the gut-microbiota-brain axis.
Psychopharmacology, , Volume: 240, Issue:5 | 2023 |
Opposing effects of β-2 and β-1 adrenergic receptor signaling on neuroinflammation and dopaminergic neuron survival in α-synuclein-mediated neurotoxicity.
Journal of neuroinflammation, , Mar-02, Volume: 20, Issue:1 | 2023 |
Isocyanate induces cytotoxicity via activation of phosphorylated alpha synuclein protein, nitrosative stress, and apoptotic pathway in Parkinson's Disease model-SHSY-5Y cells.
Neurological research, , Volume: 45, Issue:7 | 2023 |
Nuclear α-Synuclein-Derived Cytotoxic Effect via Altered Ribosomal RNA Processing in Primary Mouse Embryonic Fibroblasts.
International journal of molecular sciences, , Jan-21, Volume: 24, Issue:3 | 2023 |
The safety and effectiveness of α-synuclein immunotherapy vs. placebo for the treatment of Parkinson's disease: a systematic review and meta-analysis.
Annals of palliative medicine, , Volume: 11, Issue:12 | 2022 |
Bivalent dopamine agonists with co-operative binding and functional activities at dopamine D2 receptors, modulate aggregation and toxicity of alpha synuclein protein.
Bioorganic & medicinal chemistry, , 01-15, Volume: 78 | 2023 |
A Method to Study α-Synuclein Toxicity and Aggregation Using a Humanized Yeast Model.
Journal of visualized experiments : JoVE, , Nov-25, Issue:189 | 2022 |
Hydroxytyrosol and dopamine metabolites: Anti-aggregative effect and neuroprotective activity against α-synuclein-induced toxicity.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, , Volume: 171 | 2023 |
N-homocysteinylation of α-synuclein promotes its aggregation and neurotoxicity.
Aging cell, , Volume: 22, Issue:3 | 2023 |
Manganese-induced α-synuclein overexpression promotes the accumulation of dysfunctional synaptic vesicles and hippocampal synaptotoxicity by suppressing Rab26-dependent autophagy in presynaptic neurons.
The Science of the total environment, , Feb-01, Volume: 858, Issue:Pt 1 | 2023 |
Pharmacological inhibition of AIMP2 aggregation attenuates α-synuclein aggregation and toxicity in Parkinson's disease.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, , Volume: 156 | 2022 |
Exposure to the environmentally toxic pesticide maneb induces Parkinson's disease-like neurotoxicity in mice: A combined proteomic and metabolomic analysis.
Chemosphere, , Volume: 308, Issue:Pt 2 | 2022 |
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity.
Nature neuroscience, , Volume: 25, Issue:9 | 2022 |
C-terminal truncation modulates α-Synuclein's cytotoxicity and aggregation by promoting the interactions with membrane and chaperone.
Communications biology, , 08-09, Volume: 5, Issue:1 | 2022 |
Designer D-peptides targeting the N-terminal region of α-synuclein to prevent parkinsonian-associated fibrilization and cytotoxicity.
Biochimica et biophysica acta. Proteins and proteomics, , 10-01, Volume: 1870, Issue:10 | 2022 |
Parkinson's Disease Etiology: Insights and Associations with Phosphate Toxicity.
International journal of molecular sciences, , Jul-22, Volume: 23, Issue:15 | 2022 |
Absence of Gem1 (mammalian Miro/Rhot) mitigates alpha-synuclein toxicity in a yeast model of Parkinson's disease.
Molecular and cellular neurosciences, , Volume: 122 | 2022 |
Methanolic Extract of Boswellia serrata Gum Protects the Nigral Dopaminergic Neurons from Rotenone-Induced Neurotoxicity.
Molecular neurobiology, , Volume: 59, Issue:9 | 2022 |
Heparan sulfate proteoglycans mediate prion-like α-synuclein toxicity in Parkinson's in vivo models.
Life science alliance, , Volume: 5, Issue:11 | 2022 |
Kisspeptin-10 Rescues Cholinergic Differentiated SHSY-5Y Cells from α-Synuclein-Induced Toxicity In Vitro.
International journal of molecular sciences, , May-06, Volume: 23, Issue:9 | 2022 |
Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial.
EBioMedicine, , Volume: 80 | 2022 |
APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer's disease with Lewy body pathology.
Acta neuropathologica, , Volume: 143, Issue:6 | 2022 |
Insights into the inhibitory mechanism of skullcapflavone II against α-synuclein aggregation and its mediated cytotoxicity.
International journal of biological macromolecules, , Jun-01, Volume: 209, Issue:Pt A | 2022 |
α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity.
Proceedings of the National Academy of Sciences of the United States of America, , 04-12, Volume: 119, Issue:15 | 2022 |
Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies.
Cellular and molecular life sciences : CMLS, , Mar-04, Volume: 79, Issue:3 | 2022 |
The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity.
Molecules (Basel, Switzerland), , Feb-15, Volume: 27, Issue:4 | 2022 |
Lysophosphatidylcholine acyltransferase 1 promotes pathology and toxicity in two distinct cell-based alpha-synuclein models.
Neuroscience letters, , 02-16, Volume: 772 | 2022 |
Vitamin D3 promotes oligodendrogenesis and modulates synucleinopathy in lead-induced nigral pars compacta neurotoxicity in rats.
Folia morphologica, , Volume: 82, Issue:1 | 2023 |
Novel engineered nanobodies specific for N-terminal region of alpha-synuclein recognize Lewy-body pathology and inhibit in-vitro seeded aggregation and toxicity.
The FEBS journal, , Volume: 289, Issue:15 | 2022 |
Olfactory Bulb Excitotoxicity as a Gap-Filling Mechanism Underlying the Link Between Traumatic Brain Injury-Induced Secondary Neuronal Degeneration and Parkinson's Disease-Like Pathology.
Neurochemical research, , Volume: 47, Issue:4 | 2022 |
Lipotoxicity Downstream of α-Synuclein Imbalance: A Relevant Pathomechanism in Synucleinopathies?
Biomolecules, , 12-28, Volume: 12, Issue:1 | 2021 |
Roflupram attenuates α-synuclein-induced cytotoxicity and promotes the mitochondrial translocation of Parkin in SH-SY5Y cells overexpressing A53T mutant α-synuclein.
Toxicology and applied pharmacology, , 02-01, Volume: 436 | 2022 |
Ellagic Acid Prevents α-Synuclein Aggregation and Protects SH-SY5Y Cells from Aggregated α-Synuclein-Induced Toxicity via Suppression of Apoptosis and Activation of Autophagy.
International journal of molecular sciences, , Dec-13, Volume: 22, Issue:24 | 2021 |
Ca2+ administration prevents α-synuclein proteotoxicity by stimulating calcineurin-dependent lysosomal proteolysis.
PLoS genetics, , Volume: 17, Issue:11 | 2021 |
Kaempferol Has Potent Protective and Antifibrillogenic Effects for α-Synuclein Neurotoxicity In Vitro.
International journal of molecular sciences, , Oct-25, Volume: 22, Issue:21 | 2021 |
The influence of preconditioning with low dose of LPS on paraquat-induced neurotoxicity, microglia activation and expression of α-synuclein and synphilin-1 in the dopaminergic system.
Pharmacological reports : PR, , Volume: 74, Issue:1 | 2022 |
Nonclinical safety evaluation, pharmacokinetics, and target engagement of Lu AF82422, a monoclonal IgG1 antibody against alpha-synuclein in development for treatment of synucleinopathies.
mAbs, , Volume: 13, Issue:1 | |
A Downsized and Optimised Intracellular Library-Derived Peptide Prevents Alpha-Synuclein Primary Nucleation and Toxicity Without Impacting Upon Lipid Binding.
Journal of molecular biology, , 12-03, Volume: 433, Issue:24 | 2021 |
αS Oligomers Generated from Interactions with a Polyunsaturated Fatty Acid and a Dopamine Metabolite Differentially Interact with Aβ to Enhance Neurotoxicity.
ACS chemical neuroscience, , 11-03, Volume: 12, Issue:21 | 2021 |
Alpha-synuclein activates the classical complement pathway and mediates complement-dependent cell toxicity.
Journal of neuroinflammation, , Aug-16, Volume: 18, Issue:1 | 2021 |
SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures.
eNeuro, , Volume: 8, Issue:4 | |
Excess membrane binding of monomeric alpha-, beta- and gamma-synuclein is invariably associated with inclusion formation and toxicity.
Human molecular genetics, , 11-16, Volume: 30, Issue:23 | 2021 |
Natural Alkaloid Compounds as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity.
Molecules (Basel, Switzerland), , Jun-19, Volume: 26, Issue:12 | 2021 |
Structural Features and Toxicity of α-Synuclein Oligomers Grown in the Presence of DOPAC.
International journal of molecular sciences, , Jun-02, Volume: 22, Issue:11 | 2021 |
Physicochemical characterization of the G51D mutation of α-synuclein that is responsible for its severe cytotoxicity.
Neuroscience letters, , 08-24, Volume: 760 | 2021 |
Neuroprotective effect of selumetinib on acrolein-induced neurotoxicity.
Scientific reports, , 06-14, Volume: 11, Issue:1 | 2021 |
Safety and Tolerability of Active Immunotherapy Targeting α-Synuclein with PD03A in Patients with Early Parkinson's Disease: A Randomized, Placebo-Controlled, Phase 1 Study.
Journal of Parkinson's disease, , Volume: 11, Issue:3 | 2021 |
Assessment of Cytotoxicity of α-Synuclein in Budding Yeast Using a Spot Growth Assay and Fluorescent Microscopy.
Methods in molecular biology (Clifton, N.J.), , Volume: 2322 | 2021 |
Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo.
Molecular neurodegeneration, , 05-24, Volume: 16, Issue:1 | 2021 |
Ellagic Acid Inhibits α-Synuclein Aggregation at Multiple Stages and Reduces Its Cytotoxicity.
ACS chemical neuroscience, , 06-02, Volume: 12, Issue:11 | 2021 |
The food additive fast green FCF inhibits α-synuclein aggregation, disassembles mature fibrils and protects against amyloid-induced neurotoxicity.
Food & function, , Jun-21, Volume: 12, Issue:12 | 2021 |
Conformational distortion in a fibril-forming oligomer arrests alpha-Synuclein fibrillation and minimizes its toxic effects.
Communications biology, , 05-03, Volume: 4, Issue:1 | 2021 |
DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization.
PLoS genetics, , Volume: 17, Issue:3 | 2021 |
Neural-Induced Human Adipose Tissue-Derived Stem Cells Conditioned Medium Ameliorates Rotenone-Induced Toxicity in SH-SY5Y Cells.
International journal of molecular sciences, , Feb-26, Volume: 22, Issue:5 | 2021 |
The Role of α-Synuclein in Methamphetamine-Induced Neurotoxicity.
Neurotoxicity research, , Volume: 39, Issue:3 | 2021 |
Dose-related biphasic effect of the Parkinson's disease neurotoxin MPTP, on the spread, accumulation, and toxicity of α-synuclein.
Neurotoxicology, , Volume: 84 | 2021 |
The Cytotoxic Effect of α-Synuclein Aggregates.
Chemphyschem : a European journal of chemical physics and physical chemistry, , 03-17, Volume: 22, Issue:6 | 2021 |
Metabotropic glutamate receptor 5 inhibits α-synuclein-induced microglia inflammation to protect from neurotoxicity in Parkinson's disease.
Journal of neuroinflammation, , Jan-18, Volume: 18, Issue:1 | 2021 |
Fibrillar α-synuclein toxicity depends on functional lysosomes.
The Journal of biological chemistry, , 12-18, Volume: 295, Issue:51 | 2020 |
XCT 790 is a pharmacological aggrephagy inducer in a yeast model of proteotoxicity.
Cell biology international, , Volume: 45, Issue:3 | 2021 |
14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril model.
Acta neuropathologica communications, , 01-07, Volume: 9, Issue:1 | 2021 |
Manganese Accumulation in the Brain via Various Transporters and Its Neurotoxicity Mechanisms.
Molecules (Basel, Switzerland), , Dec-12, Volume: 25, Issue:24 | 2020 |
Pesticide interactions induce alterations in secondary structure of malate dehydrogenase to cause destability and cytotoxicity.
Chemosphere, , Volume: 263 | 2021 |
LncRNA OIP5-AS1 reduces α-synuclein aggregation and toxicity by targeting miR-126 to activate PLK2 in human neuroblastoma SH-SY5Y cells.
Neuroscience letters, , 01-01, Volume: 740 | 2021 |
Fast kinetics of environmentally induced α-synuclein aggregation mediated by structural alteration in NAC region and result in structure dependent cytotoxicity.
Scientific reports, , 10-27, Volume: 10, Issue:1 | 2020 |
Upregulation of Cellular Palmitoylation Mitigates α-Synuclein Accumulation and Neurotoxicity.
Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:2 | 2021 |
Cytotoxicity and Mitochondrial Dysregulation Caused by α-Synuclein in
Cells, , 10-14, Volume: 9, Issue:10 | 2020 |
LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies.
Science translational medicine, , 10-14, Volume: 12, Issue:565 | 2020 |
Pathogenic LRRK2 requires secondary factors to induce cellular toxicity.
Bioscience reports, , 10-30, Volume: 40, Issue:10 | 2020 |
Norepinephrine depleting toxin DSP-4 and LPS alter gut microbiota and induce neurotoxicity in α-synuclein mutant mice.
Scientific reports, , 09-14, Volume: 10, Issue:1 | 2020 |
Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein.
Molecular neurodegeneration, , 09-08, Volume: 15, Issue:1 | 2020 |
The SUMO Conjugase Ubc9 Protects Dopaminergic Cells from Cytotoxicity and Enhances the Stability of α-Synuclein in Parkinson's Disease Models.
eNeuro, , Volume: 7, Issue:5 | |
Naphthoquinone-Dopamine Hybrids Inhibit α-Synuclein Aggregation, Disrupt Preformed Fibrils, and Attenuate Aggregate-Induced Toxicity.
Chemistry (Weinheim an der Bergstrasse, Germany), , Dec-09, Volume: 26, Issue:69 | 2020 |
Amelioration of aggregate cytotoxicity by catalytic conversion of protein oligomers into amyloid fibrils.
Nanoscale, , Sep-28, Volume: 12, Issue:36 | 2020 |
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism.
Communications biology, , 08-13, Volume: 3, Issue:1 | 2020 |
Iron promotes the clearance of α-synuclein: An Editorial for 'H63D variant of the homeostatic iron regulator (HFE) gene alters α-synuclein expression, aggregation, and toxicity" on page 177.
Journal of neurochemistry, , Volume: 155, Issue:2 | 2020 |
Maysin plays a protective role against α-Synuclein oligomers cytotoxicity by triggering autophagy activation.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, , Volume: 144 | 2020 |
Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor.
International journal of molecular sciences, , Jul-22, Volume: 21, Issue:15 | 2020 |
H63D variant of the homeostatic iron regulator (HFE) gene alters α-synuclein expression, aggregation, and toxicity.
Journal of neurochemistry, , Volume: 155, Issue:2 | 2020 |
Role of alpha-synuclein phosphorylation at Serine 129 in methamphetamine-induced neurotoxicity in vitro and in vivo.
Neuroreport, , 08-05, Volume: 31, Issue:11 | 2020 |
Safety and immunogenicity of the α-synuclein active immunotherapeutic PD01A in patients with Parkinson's disease: a randomised, single-blinded, phase 1 trial.
The Lancet. Neurology, , Volume: 19, Issue:7 | 2020 |
Neuroprotective Role of Quercetin on Rotenone-Induced Toxicity in SH-SY5Y Cell Line Through Modulation of Apoptotic and Autophagic Pathways.
Neurochemical research, , Volume: 45, Issue:8 | 2020 |
Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity.
Scientific reports, , 05-18, Volume: 10, Issue:1 | 2020 |
Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits.
Neurobiology of disease, , Volume: 141 | 2020 |
Inhibition of HDAC6 activity protects dopaminergic neurons from alpha-synuclein toxicity.
Scientific reports, , 04-08, Volume: 10, Issue:1 | 2020 |
Hsp27 reduces glycation-induced toxicity and aggregation of alpha-synuclein.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , Volume: 34, Issue:5 | 2020 |
Long-term Use (17)
| Article | Year |
|---|
Anethole attenuates motor dysfunctions, striatal neuronal activity deficiency and blood brain barrier permeability by decreasing striatal α-synuclein and oxidative stress in rotenone-induced Parkinson's disease of male rats.
PloS one, , Volume: 18, Issue:11 | 2023 |
Accumulation of α-synuclein mediates podocyte injury in Fabry nephropathy.
The Journal of clinical investigation, , 06-01, Volume: 133, Issue:11 | 2023 |
Phytoconstituents of Datura metel extract improved motor coordination in haloperidol-induced cataleptic mice: Dual-target molecular docking and behavioural studies.
Journal of ethnopharmacology, , Jan-10, Volume: 300 | 2023 |
Effects of Lanthionine Ketimine-5-Ethyl Ester on the α-Synucleinopathy Mouse Model.
Neurochemical research, , Volume: 47, Issue:8 | 2022 |
GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson's Disease.
Scientific reports, , 06-10, Volume: 9, Issue:1 | 2019 |
Inhibition of MPTP-induced α-synuclein oligomerization by fatty acid-binding protein 3 ligand in MPTP-treated mice.
Neuropharmacology, , 05-15, Volume: 150 | 2019 |
Nucleic Acid-Based Therapeutics for Parkinson's Disease.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, , Volume: 16, Issue:2 | 2019 |
Chronic nicotine improves cognitive and social impairment in mice overexpressing wild type α-synuclein.
Neurobiology of disease, , Volume: 117 | 2018 |
Escalating Methamphetamine Regimen Induces Compensatory Mechanisms, Mitochondrial Biogenesis, and GDNF Expression, in Substantia Nigra.
Journal of cellular biochemistry, , Volume: 118, Issue:6 | 2017 |
Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons.
Neurobiology of disease, , Volume: 69 | 2014 |
Geraniol attenuates α-synuclein expression and neuromuscular impairment through increase dopamine content in MPTP intoxicated mice by dose dependent manner.
Biochemical and biophysical research communications, , Nov-01, Volume: 440, Issue:4 | 2013 |
Chronic intranasal deferoxamine ameliorates motor defects and pathology in the α-synuclein rAAV Parkinson's model.
Experimental neurology, , Volume: 247 | 2013 |
Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain.
Molecular psychiatry, , Volume: 18, Issue:8 | 2013 |
Valproic acid is neuroprotective in the rotenone rat model of Parkinson's disease: involvement of alpha-synuclein.
Neurotoxicity research, , Volume: 17, Issue:2 | 2010 |
Mice lacking alpha-synuclein have an attenuated loss of striatal dopamine following prolonged chronic MPTP administration.
Neurotoxicology, , Volume: 25, Issue:5 | 2004 |
Alpha-Synuclein is degraded by both autophagy and the proteasome.
The Journal of biological chemistry, , Jul-04, Volume: 278, Issue:27 | 2003 |
6-Hydroxydopamine lesioning differentially affects alpha-synuclein mRNA expression in the nucleus accumbens, striatum and substantia nigra of adult rats.
Neuroscience letters, , Mar-29, Volume: 322, Issue:1 | 2002 |
Pharmacokinetics (65)
| Article | Year |
|---|
A selective ER-phagy exerts neuroprotective effects via modulation of α-synuclein clearance in parkinsonian models.
Proceedings of the National Academy of Sciences of the United States of America, , 09-12, Volume: 120, Issue:37 | 2023 |
The mitochondrial uncoupling effects of nitazoxanide enhances cellular autophagy and promotes the clearance of α-synuclein: Potential role of AMPK-JNK pathway.
Cellular signalling, , Volume: 109 | 2023 |
A Conceptual Study on the Peripheral Clearance of Brain-Derived α-Synuclein in Humans.
Journal of Alzheimer's disease : JAD, , Volume: 90, Issue:4 | 2022 |
AMPK-dependent autophagy activation and alpha-Synuclein clearance: a putative mechanism behind alpha-mangostin's neuroprotection in a rotenone-induced mouse model of Parkinson's disease.
Metabolic brain disease, , Volume: 37, Issue:8 | 2022 |
Multiple checkpoints of protein clearance machinery are modulated by a common microRNA, miR-4813-3p, through its putative target genes: Studies employing transgenic C. elegans model.
Biochimica et biophysica acta. Molecular cell research, , Volume: 1869, Issue:12 | 2022 |
Gray Matter Volume Loss in Proposed Brain-First and Body-First Parkinson's Disease Subtypes.
Movement disorders : official journal of the Movement Disorder Society, , Volume: 37, Issue:10 | 2022 |
Artemisia Leaf Extract protects against neuron toxicity by TRPML1 activation and promoting autophagy/mitophagy clearance in both in vitro and in vivo models of MPP+/MPTP-induced Parkinson's disease.
Phytomedicine : international journal of phytotherapy and phytopharmacology, , Volume: 104 | 2022 |
Role of Ubiquitin-Proteasome and Autophagy-Lysosome Pathways in α-Synuclein Aggregate Clearance.
Molecular neurobiology, , Volume: 59, Issue:9 | 2022 |
Microgliosis and neuronal proteinopathy in brain persist beyond viral clearance in SARS-CoV-2 hamster model.
EBioMedicine, , Volume: 79 | 2022 |
Truncation-Driven Lateral Association of α-Synuclein Hinders Amyloid Clearance by the Hsp70-Based Disaggregase.
International journal of molecular sciences, , Nov-30, Volume: 22, Issue:23 | 2021 |
Nonclinical safety evaluation, pharmacokinetics, and target engagement of Lu AF82422, a monoclonal IgG1 antibody against alpha-synuclein in development for treatment of synucleinopathies.
mAbs, , Volume: 13, Issue:1 | |
Ferruginol prevents degeneration of dopaminergic neurons by enhancing clearance of α-synuclein in neuronal cells.
Fitoterapia, , Volume: 156 | 2022 |
Expression of transduced nucleolin promotes the clearance of accumulated α-synuclein in rodent cells and animal model.
Neurobiology of disease, , Volume: 154 | 2021 |
Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson's disease.
Acta neuropathologica communications, , 03-20, Volume: 9, Issue:1 | 2021 |
Parkinson's Disease-Associated LRRK2 Interferes with Astrocyte-Mediated Alpha-Synuclein Clearance.
Molecular neurobiology, , Volume: 58, Issue:7 | 2021 |
Clearance of intracellular tau protein from neuronal cells via VAMP8-induced secretion.
The Journal of biological chemistry, , 12-18, Volume: 295, Issue:51 | 2020 |
Fasudil Promotes α-Synuclein Clearance in an AAV-Mediated α-Synuclein Rat Model of Parkinson's Disease by Autophagy Activation.
Journal of Parkinson's disease, , Volume: 10, Issue:3 | 2020 |
The GTPase Rab27b regulates the release, autophagic clearance, and toxicity of α-synuclein.
The Journal of biological chemistry, , 06-05, Volume: 295, Issue:23 | 2020 |
Choroid plexus volume is associated with levels of CSF proteins: relevance for Alzheimer's and Parkinson's disease.
Neurobiology of aging, , Volume: 89 | 2020 |
Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4.
Journal of immunology (Baltimore, Md. : 1950), , 03-01, Volume: 204, Issue:5 | 2020 |
Ginkgolic acid promotes autophagy-dependent clearance of intracellular alpha-synuclein aggregates.
Molecular and cellular neurosciences, , Volume: 101 | 2019 |
Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein.
Neuron, , 12-04, Volume: 104, Issue:5 | 2019 |
Aβ, Tau, and α-Synuclein aggregation and integrated role of PARK2 in the regulation and clearance of toxic peptides.
Neuropeptides, , Volume: 78 | 2019 |
Autophagy activation promotes clearance of α-synuclein inclusions in fibril-seeded human neural cells.
The Journal of biological chemistry, , 09-27, Volume: 294, Issue:39 | 2019 |
Enhancing the Astrocytic Clearance of Extracellular α-Synuclein Aggregates by Ginkgolides Attenuates Neural Cell Injury.
Cellular and molecular neurobiology, , Volume: 39, Issue:7 | 2019 |
Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.
Nature communications, , 04-18, Volume: 10, Issue:1 | 2019 |
Pharmacokinetics and pharmacodynamics of a single dose Nilotinib in individuals with Parkinson's disease.
Pharmacology research & perspectives, , Volume: 7, Issue:2 | 2019 |
Hydroxysafflor yellow A promotes α-synuclein clearance via regulating autophagy in rotenone-induced Parkinson's disease mice.
Folia neuropathologica, , Volume: 56, Issue:2 | 2018 |
Ubiquitin specific protease-13 independently regulates parkin ubiquitination and alpha-synuclein clearance in alpha-synucleinopathies.
Human molecular genetics, , 02-15, Volume: 28, Issue:4 | 2019 |
FYCO1 mediates clearance of α-synuclein aggregates through a Rab7-dependent mechanism.
Journal of neurochemistry, , Volume: 146, Issue:4 | 2018 |
Ginkgolide K promotes the clearance of A53T mutation alpha-synuclein in SH-SY5Y cells.
Cell biology and toxicology, , Volume: 34, Issue:4 | 2018 |
Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia.
BMC neuroscience, , 11-30, Volume: 17, Issue:1 | 2016 |
Mesenchymal stem cells enhance α-synuclein clearance via M2 microglia polarization in experimental and human parkinsonian disorder.
Acta neuropathologica, , Volume: 132, Issue:5 | 2016 |
Rab7 induces clearance of α-synuclein aggregates.
Journal of neurochemistry, , Volume: 138, Issue:5 | 2016 |
Triptolide Promotes the Clearance of α-Synuclein by Enhancing Autophagy in Neuronal Cells.
Molecular neurobiology, , Volume: 54, Issue:3 | 2017 |
Acupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain.
Scientific reports, , Jan-21, Volume: 6 | 2016 |
Do Macromolecular Crowding Agents Exert Only an Excluded Volume Effect? A Protein Solvation Study.
The journal of physical chemistry. B, , Nov-05, Volume: 119, Issue:44 | 2015 |
The Interplay between Alpha-Synuclein Clearance and Spreading.
Biomolecules, , Apr-14, Volume: 5, Issue:2 | 2015 |
Genetic and chemical activation of TFEB mediates clearance of aggregated α-synuclein.
PloS one, , Volume: 10, Issue:3 | 2015 |
LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance.
Proceedings of the National Academy of Sciences of the United States of America, , Oct-28, Volume: 111, Issue:43 | 2014 |
The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse.
Neurobiology of disease, , Volume: 68 | 2014 |
Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathway.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , Volume: 9, Issue:3 | 2014 |
c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease.
Human molecular genetics, , Jun-01, Volume: 23, Issue:11 | 2014 |
Ubiquitination increases parkin activity to promote autophagic α-synuclein clearance.
PloS one, , Volume: 8, Issue:12 | 2013 |
Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice.
Human molecular genetics, , Feb-01, Volume: 23, Issue:3 | 2014 |
Tyrosine kinase inhibition facilitates autophagic SNCA/α-synuclein clearance.
Autophagy, , Volume: 9, Issue:8 | 2013 |
Crosstalk between the proteasome system and autophagy in the clearance of α-synuclein.
Acta pharmacologica Sinica, , Volume: 34, Issue:5 | 2013 |
NAD+ salvage pathway proteins suppress proteotoxicity in yeast models of neurodegeneration by promoting the clearance of misfolded/oligomerized proteins.
Human molecular genetics, , May-01, Volume: 22, Issue:9 | 2013 |
Proteolytic clearance of extracellular α-synuclein as a new therapeutic approach against Parkinson disease.
Prion, , Volume: 7, Issue:2 | |
Delay discounting of reward and caudate nucleus volume in individuals with α-synuclein gene duplication before and after the development of Parkinson's disease.
Neuro-degenerative diseases, , Volume: 11, Issue:2 | 2013 |
Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission.
The Journal of neuroscience : the official journal of the Society for Neuroscience, , Sep-26, Volume: 32, Issue:39 | 2012 |
Aggregate clearance of α-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome.
The Journal of biological chemistry, , Aug-10, Volume: 287, Issue:33 | 2012 |
Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method.
Nanoscale, , Aug-07, Volume: 4, Issue:15 | 2012 |
Lentivirus mediated delivery of neurosin promotes clearance of wild-type α-synuclein and reduces the pathology in an α-synuclein model of LBD.
Molecular therapy : the journal of the American Society of Gene Therapy, , Volume: 21, Issue:1 | 2013 |
The Parkinson's disease protein LRRK2 impairs proteasome substrate clearance without affecting proteasome catalytic activity.
Cell death & disease, , Aug-25, Volume: 2 | 2011 |
Toll-like receptor 4 promotes α-synuclein clearance and survival of nigral dopaminergic neurons.
The American journal of pathology, , Volume: 179, Issue:2 | 2011 |
Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein.
The American journal of pathology, , Volume: 175, Issue:2 | 2009 |
Intracellular targeting and clearance of oligomeric alpha-synuclein alleviates toxicity in mammalian cells.
Neuroscience letters, , Jul-31, Volume: 459, Issue:1 | 2009 |
MPP+ impairs autophagic clearance of alpha-synuclein by impairing the activity of dynein.
Neuroreport, , Apr-22, Volume: 20, Issue:6 | 2009 |
Clearance and deposition of extracellular alpha-synuclein aggregates in microglia.
Biochemical and biophysical research communications, , Aug-01, Volume: 372, Issue:3 | 2008 |
Accumulation and clearance of alpha-synuclein aggregates demonstrated by time-lapse imaging.
Journal of neurochemistry, , Volume: 106, Issue:2 | 2008 |
Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein.
The international journal of biochemistry & cell biology, , Volume: 40, Issue:9 | 2008 |
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.
The Journal of biological chemistry, , Feb-23, Volume: 282, Issue:8 | 2007 |
Lack of direct role of parkin in the steady-state level and aggregation of alpha-synuclein and the clearance of pre-formed aggregates.
Experimental neurology, , Volume: 197, Issue:2 | 2006 |
Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience, , Feb-25, Volume: 24, Issue:8 | 2004 |
Bioavailability (18)
| Article | Year |
|---|
Polysorbate 80 surface modified SLNs of formoterol suppress SNCA gene and mitochondrial oxidative stress in mice model of Parkinson's disease.
Scientific reports, , 11-15, Volume: 13, Issue:1 | 2023 |
The c-Abl inhibitor IkT-148009 suppresses neurodegeneration in mouse models of heritable and sporadic Parkinson's disease.
Science translational medicine, , 01-18, Volume: 15, Issue:679 | 2023 |
Non-Reproducibility of Oral Rotenone as a Model for Parkinson's Disease in Mice.
International journal of molecular sciences, , Oct-21, Volume: 23, Issue:20 | 2022 |
Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial.
EBioMedicine, , Volume: 80 | 2022 |
Ca2+ administration prevents α-synuclein proteotoxicity by stimulating calcineurin-dependent lysosomal proteolysis.
PLoS genetics, , Volume: 17, Issue:11 | 2021 |
Disease-modifying treatment of Parkinson's disease by phytochemicals: targeting multiple pathogenic factors.
Journal of neural transmission (Vienna, Austria : 1996), , Volume: 129, Issue:5-6 | 2022 |
ATH434 Reverses Colorectal Dysfunction in the A53T Mouse Model of Parkinson's Disease.
Journal of Parkinson's disease, , Volume: 11, Issue:4 | 2021 |
ATH434 Reduces α-Synuclein-Related Neurodegeneration in a Murine Model of Multiple System Atrophy.
Movement disorders : official journal of the Movement Disorder Society, , Volume: 36, Issue:11 | 2021 |
Targeted graphene oxide for drug delivery as a therapeutic nanoplatform against Parkinson's disease.
Biomaterials science, , Mar-10, Volume: 9, Issue:5 | 2021 |
In silico drug repositioning of FDA-approved drugs to predict new inhibitors for alpha-synuclein aggregation.
Computational biology and chemistry, , Volume: 88 | 2020 |
Nose to brain delivery of rotigotine loaded chitosan nanoparticles in human SH-SY5Y neuroblastoma cells and animal model of Parkinson's disease.
International journal of pharmaceutics, , Apr-15, Volume: 579 | 2020 |
Heterogeneity in gut microbiota drive polyphenol metabolism that influences α-synuclein misfolding and toxicity.
The Journal of nutritional biochemistry, , Volume: 64 | 2019 |
The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson's disease.
Scientific reports, , 11-01, Volume: 8, Issue:1 | 2018 |
Interaction of α-synuclein with Rhus typhina tannin - Implication for Parkinson's disease.
Colloids and surfaces. B, Biointerfaces, , Jul-01, Volume: 155 | 2017 |
Delivery of Dual Drug Loaded Lipid Based Nanoparticles across the Blood-Brain Barrier Impart Enhanced Neuroprotection in a Rotenone Induced Mouse Model of Parkinson's Disease.
ACS chemical neuroscience, , 12-21, Volume: 7, Issue:12 | 2016 |
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease.
Acta neuropathologica, , Volume: 125, Issue:6 | 2013 |
GSM-900MHz at low dose temperature-dependently downregulates α-synuclein in cultured cerebral cells independently of chaperone-mediated-autophagy.
Toxicology, , Feb-26, Volume: 292, Issue:2-3 | 2012 |
Oral administration of rotenone using a gavage and image analysis of alpha-synuclein inclusions in the enteric nervous system.
Journal of visualized experiments : JoVE, , Oct-26, Issue:44 | 2010 |
Dosage (90)
| Article | Year |
|---|
Neuronal SNCA transcription during Lewy body formation.
Acta neuropathologica communications, , 11-23, Volume: 11, Issue:1 | 2023 |
Effects of ozone treatment to the levels of neurodegeneration biomarkers after rotenone induced rat model of Parkinson's disease.
Neuroscience letters, , 09-25, Volume: 814 | 2023 |
Aggregation of alpha-synuclein in enteric neurons does not impact function in vitro.
Scientific reports, , 12-23, Volume: 12, Issue:1 | 2022 |
Generation of a homozygous and a heterozygous SNCA gene knockout human-induced pluripotent stem cell line by CRISPR/Cas9 mediated allele-specific tuning of SNCA expression.
Stem cell research, , Volume: 65 | 2022 |
Isogenic human SNCA gene dosage induced pluripotent stem cells to model Parkinson's disease.
Stem cell research, , Volume: 60 | 2022 |
Non-clinical Pharmacology of YTX-7739: a Clinical Stage Stearoyl-CoA Desaturase Inhibitor Being Developed for Parkinson's Disease.
Molecular neurobiology, , Volume: 59, Issue:4 | 2022 |
The Compound ATH434 Prevents Alpha-Synuclein Toxicity in a Murine Model of Multiple System Atrophy.
Journal of Parkinson's disease, , Volume: 12, Issue:1 | 2022 |
The potential neuroprotective effect of diosmin in rotenone-induced model of Parkinson's disease in rats.
European journal of pharmacology, , Jan-05, Volume: 914 | 2022 |
Mechanistic insights into the protective effect of paracetamol against rotenone-induced Parkinson's disease in rats: Possible role of endocannabinoid system modulation.
International immunopharmacology, , Volume: 94 | 2021 |
A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α-Synuclein Mice.
Annals of neurology, , Volume: 89, Issue:1 | 2021 |
The effect of copy number on α-synuclein's toxicity and its protective role in Bax-induced apoptosis, in yeast.
Bioscience reports, , 09-30, Volume: 40, Issue:9 | 2020 |
Neuroprotection of Rotenone-Induced Parkinsonism by Ursolic Acid in PD Mouse Model.
CNS & neurological disorders drug targets, , Volume: 19, Issue:7 | 2020 |
Demonstration of brain region-specific neuronal vulnerability in human iPSC-based model of familial Parkinson's disease.
Human molecular genetics, , 05-08, Volume: 29, Issue:7 | 2020 |
Replication-Based Rearrangements Are a Common Mechanism for SNCA Duplication in Parkinson's Disease.
Movement disorders : official journal of the Movement Disorder Society, , Volume: 35, Issue:5 | 2020 |
[Current Status and Future Prospects of Therapeutic Development of Parkinson's Disease].
Brain and nerve = Shinkei kenkyu no shinpo, , Volume: 72, Issue:1 | 2020 |
Early impairment of epigenetic pattern in neurodegeneration: Additional mechanisms behind pyrethroid toxicity.
Experimental gerontology, , Volume: 124 | 2019 |
α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies.
Proceedings of the National Academy of Sciences of the United States of America, , 07-24, Volume: 115, Issue:30 | 2018 |
Age-related Beta-synuclein Alters the p53/Mdm2 Pathway and Induces the Apoptosis of Brain Microvascular Endothelial Cells In Vitro.
Cell transplantation, , Volume: 27, Issue:5 | 2018 |
Gangliosides, α-Synuclein, and Parkinson's Disease.
Progress in molecular biology and translational science, , Volume: 156 | 2018 |
Alpha-synuclein induces the unfolded protein response in Parkinson's disease SNCA triplication iPSC-derived neurons.
Human molecular genetics, , 11-15, Volume: 26, Issue:22 | 2017 |
The 200-year journey of Parkinson disease: Reflecting on the past and looking towards the future.
Parkinsonism & related disorders, , Volume: 46 Suppl 1 | 2018 |
αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson's disease.
Scientific reports, , 07-11, Volume: 7, Issue:1 | 2017 |
α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies.
Nature medicine, , Feb-07, Volume: 23, Issue:2 | 2017 |
Toxic effects of human and rodent variants of alpha-synuclein in vivo.
The European journal of neuroscience, , Volume: 45, Issue:4 | 2017 |
The heterozygous A53T mutation in the alpha-synuclein gene in a Chinese Han patient with Parkinson disease: case report and literature review.
Journal of neurology, , Volume: 263, Issue:10 | 2016 |
Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity.
Human molecular genetics, , Jan-15, Volume: 25, Issue:2 | 2016 |
L-dopa increases α-synuclein DNA methylation in Parkinson's disease patients in vivo and in vitro.
Movement disorders : official journal of the Movement Disorder Society, , Volume: 30, Issue:13 | 2015 |
Effects of methylmercury on dopamine release in MN9D neuronal cells.
Toxicology mechanisms and methods, , Volume: 25, Issue:8 | 2015 |
Mechanisms of alpha-synuclein action on neurotransmission: cell-autonomous and non-cell autonomous role.
Biomolecules, , May-13, Volume: 5, Issue:2 | 2015 |
Neuropathic alterations of the myenteric plexus neurons following subacute intraperitoneal administration of salsolinol.
Folia histochemica et cytobiologica, , Volume: 53, Issue:1 | 2015 |
Multiple system atrophy: the application of genetics in understanding etiology.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society, , Volume: 25, Issue:1 | 2015 |
Blood α-synuclein in agricultural pesticide handlers in central Washington State.
Environmental research, , Volume: 136 | 2015 |
Noradrenergic and serotonergic neurochemistry arising from intranasal inoculation with α-synuclein aggregates which incite parkinsonian-like symptoms.
Behavioural brain research, , Feb-15, Volume: 279 | 2015 |
LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance.
Proceedings of the National Academy of Sciences of the United States of America, , Oct-28, Volume: 111, Issue:43 | 2014 |
Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression.
Human molecular genetics, , Feb-15, Volume: 24, Issue:4 | 2015 |
Cardiac sympathetic denervation in 6-OHDA-treated nonhuman primates.
PloS one, , Volume: 9, Issue:8 | 2014 |
A 6.4 Mb duplication of the α-synuclein locus causing frontotemporal dementia and Parkinsonism: phenotype-genotype correlations.
JAMA neurology, , Volume: 71, Issue:9 | 2014 |
Intranasal administration of alpha-synuclein aggregates: a Parkinson's disease model with behavioral and neurochemical correlates.
Behavioural brain research, , Apr-15, Volume: 263 | 2014 |
Genetic assessment of familial and early-onset Parkinson's disease in a Greek population.
European journal of neurology, , Volume: 21, Issue:7 | 2014 |
In vivo modulation of polo-like kinases supports a key role for PLK2 in Ser129 α-synuclein phosphorylation in mouse brain.
Neuroscience, , Jan-03, Volume: 256 | 2014 |
Nasal inoculation with α-synuclein aggregates evokes rigidity, locomotor deficits and immunity to such misfolded species as well as dopamine.
Behavioural brain research, , Apr-15, Volume: 243 | 2013 |
A case of α-synuclein gene duplication presenting with head-shaking movements.
Movement disorders : official journal of the Movement Disorder Society, , Volume: 28, Issue:3 | 2013 |
Variants in the 3'UTR of SNCA do not affect miRNA-433 binding and alpha-synuclein expression.
European journal of human genetics : EJHG, , Volume: 20, Issue:12 | 2012 |
Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice.
PloS one, , Volume: 7, Issue:5 | 2012 |
α-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion.
Neuroscience research, , Volume: 73, Issue:2 | 2012 |
Analysis of LRRK2, SNCA, Parkin, PINK1, and DJ-1 in Zambian patients with Parkinson's disease.
Parkinsonism & related disorders, , Volume: 18, Issue:5 | 2012 |
Increased expression of α-synuclein by SNCA duplication is associated with resistance to toxic stimuli.
Journal of molecular neuroscience : MN, , Volume: 47, Issue:2 | 2012 |
Exon dosage variations in Brazilian patients with Parkinson's disease: analysis of SNCA, PARKIN, PINK1 and DJ-1 genes.
Disease markers, , Volume: 32, Issue:3 | 2012 |
Curcumin-glucoside, a novel synthetic derivative of curcumin, inhibits α-synuclein oligomer formation: relevance to Parkinson's disease.
Current pharmaceutical design, , Volume: 18, Issue:1 | 2012 |
Macroautophagy and the proteasome are differently involved in the degradation of alpha-synuclein wild type and mutated A30P in an in vitro inducible model (PC12/TetOn).
Neuroscience, , Nov-10, Volume: 195 | 2011 |
The effect of SNCA 3' region on the levels of SNCA-112 splicing variant.
Neurogenetics, , Volume: 12, Issue:1 | 2011 |
Dual effects of alpha-synuclein on neurotoxicity induced by low dosage of rotenone are dependent on exposure time in dopaminergic neuroblastoma cells.
Science China. Life sciences, , Volume: 53, Issue:5 | 2010 |
Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update.
Human mutation, , Volume: 31, Issue:7 | 2010 |
Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains.
The Journal of neuroscience : the official journal of the Society for Neuroscience, , May-05, Volume: 30, Issue:18 | 2010 |
Alpha-synuclein nitration and autophagy response are induced in peripheral blood cells from patients with Parkinson disease.
Neuroscience letters, , Jun-14, Volume: 477, Issue:1 | 2010 |
Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis.
Neuron, , Jan-14, Volume: 65, Issue:1 | 2010 |
Analysis of exon dosage using MLPA in South African Parkinson's disease patients.
Neurogenetics, , Volume: 11, Issue:3 | 2010 |
Genetic regulation of alpha-synuclein mRNA expression in various human brain tissues.
PloS one, , Oct-16, Volume: 4, Issue:10 | 2009 |
Lipidomic profiling in mouse brain reveals differences between ages and genders, with smaller changes associated with alpha-synuclein genotype.
Journal of neurochemistry, , Volume: 111, Issue:1 | 2009 |
[Analysis of the alpha-synuclein gene dosage variation associated with autosomal dominant form of ParkinsonTs disease].
Genetika, , Volume: 45, Issue:4 | 2009 |
Alpha-synuclein and familial Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society, , Jun-15, Volume: 24, Issue:8 | 2009 |
Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element.
International journal of molecular sciences, , Volume: 10, Issue:3 | 2009 |
Alpha-synuclein gene rearrangements in dominantly inherited parkinsonism: frequency, phenotype, and mechanisms.
Archives of neurology, , Volume: 66, Issue:1 | 2009 |
Application of a C. elegans dopamine neuron degeneration assay for the validation of potential Parkinson's disease genes.
Journal of visualized experiments : JoVE, , Jul-18, Issue:17 | 2008 |
Genotypic and phenotypic characteristics of Dutch patients with early onset Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society, , Jan-30, Volume: 24, Issue:2 | 2009 |
Mutation analyses in amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula, Japan.
Movement disorders : official journal of the Movement Disorder Society, , Dec-15, Volume: 23, Issue:16 | 2008 |
Analysis of PARK genes in a Korean cohort of early-onset Parkinson disease.
Neurogenetics, , Volume: 9, Issue:4 | 2008 |
GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein.
Proceedings of the National Academy of Sciences of the United States of America, , Aug-05, Volume: 105, Issue:31 | 2008 |
Genomic investigation of alpha-synuclein multiplication and parkinsonism.
Annals of neurology, , Volume: 63, Issue:6 | 2008 |
Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementia.
Archives of neurology, , Volume: 65, Issue:4 | 2008 |
Analysis of Parkinson disease patients from Portugal for mutations in SNCA, PRKN, PINK1 and LRRK2.
BMC neurology, , Jan-22, Volume: 8 | 2008 |
Multiplex ligation-dependent probe amplification assay for simultaneous detection of Parkinson's disease gene rearrangements.
Movement disorders : official journal of the Movement Disorder Society, , Nov-15, Volume: 22, Issue:15 | 2007 |
Disrupted visceral feedback reduces locomotor activity and influences background contextual fear conditioning in C57BL/6JOlaHsd mice.
Behavioural brain research, , Aug-22, Volume: 182, Issue:1 | 2007 |
Pathogenic mutations in Parkinson disease.
Human mutation, , Volume: 28, Issue:7 | 2007 |
Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity.
Neuron, , Feb-15, Volume: 53, Issue:4 | 2007 |
Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD.
Experimental neurology, , Volume: 204, Issue:1 | 2007 |
Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication.
Neurology, , Mar-20, Volume: 68, Issue:12 | 2007 |
Screening for SNCA and LRRK2 mutations in Greek sporadic and autosomal dominant Parkinson's disease: identification of two novel LRRK2 variants.
European journal of neurology, , Volume: 14, Issue:1 | 2007 |
Convergent roles of alpha-synuclein, DA metabolism, and the ubiquitin-proteasome system in nigrostriatal toxicity.
Annals of the New York Academy of Sciences, , Volume: 1074 | 2006 |
Association of alpha-synuclein Rep1 polymorphism and Parkinson's disease: influence of Rep1 on age at onset.
Movement disorders : official journal of the Movement Disorder Society, , Volume: 21, Issue:4 | 2006 |
Gene dosage and pathogenesis of Parkinson's disease.
Trends in molecular medicine, , Volume: 11, Issue:3 | 2005 |
Alpha-synuclein mRNA expression in sporadic Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society, , Volume: 20, Issue:5 | 2005 |
Unaltered alpha-synuclein blood levels in juvenile Parkinsonism with a parkin exon 4 deletion.
Neuroscience letters, , Feb-21, Volume: 374, Issue:3 | 2005 |
Failure to find alpha-synuclein gene dosage changes in 190 patients with familial Parkinson disease.
Archives of neurology, , Volume: 62, Issue:1 | 2005 |
The role of alpha-synuclein gene multiplications in early-onset Parkinson's disease and dementia with Lewy bodies.
Journal of neural transmission (Vienna, Austria : 1996), , Volume: 112, Issue:9 | 2005 |
Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease.
Lancet (London, England), , Volume: 364, Issue:9440 | |
Alpha-synuclein locus duplication as a cause of familial Parkinson's disease.
Lancet (London, England), , Volume: 364, Issue:9440 | |
Inhibiting aggregation of alpha-synuclein with human single chain antibody fragments.
Biochemistry, , Mar-16, Volume: 43, Issue:10 | 2004 |
Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation.
Molecular and cellular neurosciences, , Volume: 24, Issue:2 | 2003 |
Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease.
Acta neuropathologica, , Volume: 100, Issue:3 | 2000 |
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