Page last updated: 2024-12-07

fr 900482

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

FR 900482: isolated from Streptomyces sandaensis; structure given in above source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	130513
MeSH ID	M0151069

Synonyms (12)

Synonym
102363-08-6
fr-900482
antibiotic fr 900482
fr900482
brn 4886722
fr 900482
3,9-epoxy-3h-azirino(2,3-c)(1)benzazocine-5-carboxaldehyde, 8-(((aminocarbonyl)oxy)methyl)-1,1a,2,8,9,9a-hexahydro-7,9-dihydroxy-
4-formyl-6,9-dihydroxy-14-oxa-1,11-diazatetracyclo(7.4.1.o(2,7).o(10,12))tetradeca-2,4,6-triene-8-ylmethyl carbamate
3,9-epoxy-3h-azirino(2,3-c)(1)benzazocine-5-carboxaldehyde, 1,1a,2,8,9,9a-hexahydro-8-(((aminocarbonyl)oxy)methyl)-7,9-dihydroxy-
[(8r,9r,10r,12r)-4-formyl-6,9-dihydroxy-14-oxa-1,11-diazatetracyclo[7.4.1.02,7.010,12]tetradeca-2(7),3,5-trien-8-yl]methyl carbamate
DTXSID80907402
(5-formyl-7,9-dihydroxy-1,1a,2,8,9,9a-hexahydro-3,9-epoxyazireno[2,3-c][1]benzazocin-8-yl)methyl hydrogen carbonimidate

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (29)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	6 (20.69)	18.7374
1990's	1 (3.45)	18.2507
2000's	17 (58.62)	29.6817
2010's	5 (17.24)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.78

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.78 (24.57)
Research Supply Index	3.40 (2.92)
Research Growth Index	5.18 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.78)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (6.90%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	27 (93.10%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
glycine [no description available]	2.01	1	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
mitomycin Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.	4.49	7	mitomycin	alkylating agent; antineoplastic agent
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	2.44	2	metal allergen; nickel group element atom; platinum group metal atom
fluorine Fluorine: A nonmetallic, diatomic gas that is a trace element and member of the halogen family. It is used in dentistry as fluoride (FLUORIDES) to prevent dental caries.	2.03	1	diatomic fluorine; gas molecular entity	NMR chemical shift reference compound
dimethyldioxirane dimethyldioxirane: structure given in first source; powerful oxidizing agent	2.01	1
fr 66979 FR 66979: structure given in first source; isolated from Streptomyces sandaensis	2.72	3
3-amino-5-hydroxybenzoic acid 3-amino-5-hydroxybenzoic acid: direct precursor of 7-carbon amino starter-unit for biosyn of ansamycins. 3-amino-5-hydroxybenzoic acid : A monohydroxybenzoic acid that is 3-hydroxybenzoic acid carrying an additional amino substitutent at position 4.	1.97	1	aminobenzoic acid; monohydroxybenzoic acid
fr 66973 FR 66973: antitumor antibiotic from Streptomyces sandaensis; more potent against B16 melanoma & P388 leukemia than mitomycin C; structure given in first source	3.55	2
vinylglycine vinylglycine: irreversible inhibitor of aspartate aminotransferase; structure. L-vinylglycine : A non-proteinogenic L-alpha-amino acid with a structure in which a vinyl group is bonded to the alpha-carbon of glycine.	2.01	1	glycine derivative; L-alpha-amino acid zwitterion; non-proteinogenic L-alpha-amino acid	EC 4.4.1.14 (1-aminocyclopropane-1-carboxylate synthase) inhibitor
glucosamine D-glucosamine : An amino sugar whose structure comprises D-glucose having an amino substituent at position 2.. 2-amino-2-deoxy-D-glucopyranose : A D-glucosamine whose structure comprises D-glucopyranose having an amino substituent at position 2.	1.97	1	D-glucosamine	Escherichia coli metabolite; geroprotector; mouse metabolite
mitosene mitosene: structure given in first source	2.01	1
alvocidib alvocidib: structure given in first source. alvocidib : A synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation.	3.19	1	dihydroxyflavone; hydroxypiperidine; monochlorobenzenes; tertiary amino compound	antineoplastic agent; antirheumatic drug; apoptosis inducer; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
piperidines Piperidines: A family of hexahydropyridines.	3.19	1
11-acetyl-8-carbamoyloxymethyl,4-formyl-6-methoxy-14-oxa-1,11-diazatetracyclo(7.4.1.0.0)tetradeca-2,4,6-trien-9-yl acetate FK 317 dihydrobenzoxazine: a substituted dihyrobenzoxazine; structure given in first source	2.01	1

Condition	Relationship Strength	Studies
Disease Exacerbation [description not available]	3.01	1
Benign Neoplasms [description not available]	3.01	1
Invasiveness, Neoplasm [description not available]	3.01	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	3.01	1
Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.	2.41	2
Capillary Leak Syndrome A condition characterized by recurring episodes of fluid leaking from capillaries into extra-vascular compartments causing hematocrit to rise precipitously. If not treated, generalized vascular leak can lead to generalized EDEMA; SHOCK; cardiovascular collapse; and MULTIPLE ORGAN FAILURE.	2.01	1
Leukemia L 1210 [description not available]	1.97	1
Experimental Neoplasms [description not available]	1.97	1

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