methyl-ethyl-ketone-peroxide has been researched along with Necrosis* in 2 studies
2 other study(ies) available for methyl-ethyl-ketone-peroxide and Necrosis
| Article | Year |
|---|---|
Peripheral zonal hepatic necrosis caused by accidental ingestion of methyl ethyl ketone peroxide.
Fatal massive peripheral zonal hepatic necrosis developed in a 47-year-old man who accidentally ingested a solution of methyl ethyl ketone peroxide (MEKP) in dimethyl phthalate. Such solutions contain about 10% active oxygen. The clinical course was characterized by temporary cardiac arrest, abdominal burns, severe metabolic acidosis, rapid hepatic failure, rhabdomyolysis and respiratory insufficiency. A fatal outcome resulted 4 d afterwards from hepatic coma associated with blood coagulation disorders. Microscopical examination revealed massive periportal hepatic necrosis accompanied by atypical pseudoductular proliferation. The proliferating cells were probably of bile duct origin and exhibited atypia and mitoses. The pathogenetic mechanism may involve lipid peroxidation caused by free oxygen radicals derived from MEKP. Topics: Butanones; Chemical and Drug Induced Liver Injury; Humans; Liver; Male; Middle Aged; Necrosis; Oxygen; Peroxides | 1990 |
Suicide by ingestion of methyl ethyl ketone peroxide.
Methyl ethyl ketone peroxide (MEKP) is a free radical-generating compound used as a fiberglass resin hardener. A 41-year-old Haitian man developed severe metabolic acidosis, hemolysis, esophageal and gastric necrosis, and perforation of the stomach after drinking an undetermined amount of MEKP in a successful suicide attempt. The biochemical effects of free radicals explain the necrosis and hemolysis observed. Topics: Abdomen; Adult; Autopsy; Butanones; Esophagus; Humans; Male; Mucous Membrane; Necrosis; Paint; Peroxides; Suicide | 1986 |