UDP-glucuronosyltransferase 1A7

A protein that is a translation product of the UGT1A7 gene in human. [PRO:DAN, UniProtKB:Q9HAW7]

Synonyms

UGT1A7;
EC 2.4.1.17;
UDP-glucuronosyltransferase 1-7;
UDPGT 1-7;
UGT1*7;
UGT1-07;
UGT1.7;
UDP-glucuronosyltransferase 1-G;
UGT-1G;
UGT1G

Research

Bioassay Publications (5)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (20.00)	29.6817
2010's	3 (60.00)	24.3611
2020's	1 (20.00)	2.80

Compounds (8)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
diclofenac	Homo sapiens (human)	Ki	19.0000	1	1
probenecid	Homo sapiens (human)	Ki	96.0000	1	1
irilone	Homo sapiens (human)	Ki	101.0000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ezogabine	Homo sapiens (human)	EC50	3.9000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
edaravone	Homo sapiens (human)	Km	432.3000	1	1
sn 38	Homo sapiens (human)	Km	5.0000	1	1
mycophenolic acid	Homo sapiens (human)	Km	30.0000	1	1
scutellarein	Homo sapiens (human)	Km	33.3000	1	1
irilone	Homo sapiens (human)	Km	9.4000	1	1

Enables

This protein enables 7 target(s):

Target	Category	Definition
retinoic acid binding	molecular function	Binding to retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. [GOC:hjd]
enzyme inhibitor activity	molecular function	Binds to and stops, prevents or reduces the activity of an enzyme. [GOC:ai, GOC:ebc]
protein kinase C binding	molecular function	Binding to protein kinase C. [GOC:jl]
glucuronosyltransferase activity	molecular function	Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. [RHEA:21032]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
protein homodimerization activity	molecular function	Binding to an identical protein to form a homodimer. [GOC:jl]
protein heterodimerization activity	molecular function	Binding to a nonidentical protein to form a heterodimer. [GOC:ai]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]

Involved In

This protein is involved in 9 target(s):

Target	Category	Definition
xenobiotic metabolic process	biological process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc]
estrogen metabolic process	biological process	The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. [ISBN:0198506732]
coumarin metabolic process	biological process	The chemical reactions and pathways involving coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids. [GOC:lr, GOC:yl]
retinoic acid metabolic process	biological process	The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A. [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
flavone metabolic process	biological process	The chemical reactions and pathways involving flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone). [PMID:18567791]
cellular glucuronidation	biological process	The modification of an organic chemical by the conjugation of glucuronic acid. The substances resulting from glucuronidation are known as glucuronosides (or glucuronides) and are often much more water-soluble than the non-glucuronic acid-containing precursor. [GOC:BHF]
flavonoid glucuronidation	biological process	The modification of a flavonoid by the conjugation of glucuronic acid. The resultant flavonoid glucuronosides are often much more water-soluble than the precursor. [GOC:BHF, PMID:20056724]
xenobiotic glucuronidation	biological process	The modification of a xenobiotic substance by the conjugation of glucuronic acid. The resultant glucuronosides are often much more water-soluble than the xenobiotic precursor, enabling efficient excretion. [GOC:BHF, PMID:20056724]
liver development	biological process	The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. [GOC:add, ISBN:068340007X]