Page last updated: 2024-12-07

dimephosphon

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Dimephosphon is a synthetic bisphosphonate drug. It is not readily available commercially and has not been extensively studied in humans. Its synthesis involves reactions with phosphorus trichloride and various alcohols. Dimephosphon has been shown to inhibit bone resorption in animal models, suggesting potential applications in the treatment of osteoporosis. However, its toxicity and lack of clinical trials have limited its use. Research into dimephosphon focuses on its potential as a bone resorption inhibitor and its interaction with bone metabolism. Further studies are needed to evaluate its safety and efficacy in human subjects.'

dimephosphon: previous RN 86003-41-0 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID122179
SCHEMBL ID8350477
MeSH IDM0142128

Synonyms (15)

Synonym
dimephosphon
phosphonic acid, (1,1-dimethyl-3-oxobutyl)-, dimethyl ester
(1,1-dimethyl-3-oxobutyl)phosphonic acid dimethyl ester
4-dimethoxyphosphoryl-4-methylpentan-2-one
dimethyl (1,1-dimethyl-3-oxobutyl)phosphonate
136cqc28us ,
unii-136cqc28us
14394-26-4
dimethyloxobuthylphosphonilmethylate [who-dd]
dimephosphone [who-dd]
dimephosphone
SCHEMBL8350477
DTXSID20162578
2-dimethoxyphosphoryl-2-methylpentan-4-one
Q27251486

Research Excerpts

Treatment

Treatment with dimephosphone prevented or attenuated significantly acidosis, water imbalance, and pathomorphological disorders in the vascular system, nervous and glial elements of the brain.

ExcerptReferenceRelevance
"Treatment with dimephosphon contributed to preservation of conduction function of the spinal cord and decrease in excitability of spinal motoneurons in the perifocal zone."( Effect of dimephosphon on functional recovery of damaged spinal cord.
Eremeev, AM; Ibragimov, YKh; Pleshchinskii, IN; Tumakaev, RF; Yafarova, GG, 2006
)
1.08
"Pretreatment with dimephosphone prevented or attenuated significantly acidosis, water imbalance, and pathomorphological disorders in the vascular system, nervous and glial elements of the brain of the rabbits examined."( [Morphofunctional changes in the vascular system of the rabbit brain in rocking during anti-orthostatic position and administration of dimephosphon].
Beketov, AI; Kolbasin, PN; Skoromnyĭ, NA; Vasil'ev, KK,
)
0.66
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (30)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (10.00)18.7374
1990's9 (30.00)18.2507
2000's14 (46.67)29.6817
2010's4 (13.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.22

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.22 (24.57)
Research Supply Index4.09 (2.92)
Research Growth Index4.73 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.22)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials4 (7.27%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other51 (92.73%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]