Proteins > Sodium channel protein type 3 subunit alpha
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Sodium channel protein type 3 subunit alpha
A sodium channel protein type 3 subunit alpha that is encoded in the genome of rat. [OMA:P08104, PRO:DNx]
Synonyms
Sodium channel protein brain III subunit alpha;
Sodium channel protein type III subunit alpha;
Voltage-gated sodium channel subtype III;
Voltage-gated sodium channel subunit alpha Nav1.3
Research
Bioassay Publications (10)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (60.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (20)
Drugs with Potency Measurements
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| carbamazepine | Rattus norvegicus (Norway rat) | IC50 | 167.0000 | 1 | 2 |
| racemethorphan | Rattus norvegicus (Norway rat) | IC50 | 150.6500 | 2 | 2 |
| lidocaine | Rattus norvegicus (Norway rat) | IC50 | 56.0000 | 1 | 2 |
| lamotrigine | Rattus norvegicus (Norway rat) | IC50 | 82.6333 | 2 | 3 |
| lidoflazine | Rattus norvegicus (Norway rat) | Ki | 0.0770 | 1 | 1 |
| mexiletine | Rattus norvegicus (Norway rat) | IC50 | 47.0000 | 1 | 1 |
| sipatrigine | Rattus norvegicus (Norway rat) | IC50 | 17.8500 | 1 | 1 |
| lubeluzole | Rattus norvegicus (Norway rat) | IC50 | 2.9390 | 1 | 1 |
| lifarizine | Rattus norvegicus (Norway rat) | IC50 | 0.4940 | 1 | 1 |
| l 741742 | Rattus norvegicus (Norway rat) | Ki | 1.9000 | 1 | 1 |
| lacosamide | Rattus norvegicus (Norway rat) | IC50 | 0.4150 | 2 | 2 |
| oxytocin | Rattus norvegicus (Norway rat) | Ki | 0.0610 | 1 | 2 |
| (S)-(-)-pindolol | Rattus norvegicus (Norway rat) | Ki | 0.1100 | 1 | 1 |
| flunarizine | Rattus norvegicus (Norway rat) | Ki | 0.0530 | 1 | 1 |
| ica-121431 | Rattus norvegicus (Norway rat) | IC50 | 0.0060 | 1 | 1 |
| dextromethorphan | Rattus norvegicus (Norway rat) | IC50 | 5.6500 | 2 | 2 |
| tetrodotoxin | Rattus norvegicus (Norway rat) | IC50 | 0.0150 | 1 | 0 |
2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators.Bioorganic & medicinal chemistry letters, , Jul-05, Volume: 14, Issue:13, 2004
Sodium channel activity and sigma binding of 2-aminopropanamide anticonvulsants.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 9, Issue:17, 1999
The discovery of a potent NaMedChemComm, , Jun-01, Volume: 8, Issue:6, 2017
Ion channels as therapeutic targets: a drug discovery perspective.Journal of medicinal chemistry, , Feb-14, Volume: 56, Issue:3, 2013
Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as use-dependent sodium channel blockers for the treatment of stroke.Journal of medicinal chemistry, , Aug-15, Volume: 45, Issue:17, 2002
Sodium channel activity and sigma binding of 2-aminopropanamide anticonvulsants.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 9, Issue:17, 1999