A fatty acid synthase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49327]
EC 2.3.1.85;
Type I fatty acid synthase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| lansoprazole | Homo sapiens (human) | IC50 | 87.9000 | 3 | 3 |
| lansoprazole | Homo sapiens (human) | Ki | 3.5000 | 2 | 2 |
| omeprazole | Homo sapiens (human) | IC50 | 29.6000 | 1 | 1 |
| omeprazole | Homo sapiens (human) | Ki | 3.4000 | 1 | 1 |
| pantoprazole | Homo sapiens (human) | IC50 | 36.2000 | 1 | 1 |
| pantoprazole | Homo sapiens (human) | Ki | 4.1000 | 1 | 1 |
| rabeprazole | Homo sapiens (human) | IC50 | 52.0000 | 1 | 1 |
| rabeprazole | Homo sapiens (human) | Ki | 5.9000 | 1 | 1 |
| methionine | Homo sapiens (human) | Ki | 150,000.0000 | 1 | 1 |
| 3-hydroxyflavone | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| epigallocatechin gallate | Homo sapiens (human) | IC50 | 51.9700 | 1 | 1 |
| epicatechin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| (+)-epicatechin | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| s-adenosylhomocysteine | Homo sapiens (human) | Ki | 150.0000 | 1 | 1 |
| 5'-methylthioadenosine | Homo sapiens (human) | Ki | 1,500.0000 | 1 | 1 |
| egonol | Homo sapiens (human) | IC50 | 91.0700 | 1 | 1 |
| orlistat | Homo sapiens (human) | IC50 | 69.6600 | 3 | 3 |
| orlistat | Homo sapiens (human) | Ki | 0.2800 | 1 | 1 |
| luteolin | Homo sapiens (human) | IC50 | 62.5000 | 1 | 1 |
| gentisein | Homo sapiens (human) | IC50 | 40.9800 | 1 | 1 |
| mangostin | Homo sapiens (human) | IC50 | 5.5400 | 1 | 1 |
| norathyriol | Homo sapiens (human) | IC50 | 17.8500 | 1 | 1 |
| cerulenin | Homo sapiens (human) | IC50 | 13.5533 | 3 | 3 |
| trans-10,cis-12-conjugated linoleic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| gamma-mangostin | Homo sapiens (human) | IC50 | 1.2400 | 1 | 1 |
| beta-Mangostin | Homo sapiens (human) | IC50 | 24.8300 | 1 | 1 |
| 9-Hydroxycalabaxanthone | Homo sapiens (human) | IC50 | 40.6400 | 1 | 1 |
| 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid | Homo sapiens (human) | IC50 | 45.7150 | 2 | 2 |
| garcinone e | Homo sapiens (human) | IC50 | 3.3000 | 1 | 1 |
| omdm 169 | Homo sapiens (human) | IC50 | 1.3700 | 1 | 2 |
| gsk837149a | Homo sapiens (human) | IC50 | 0.0158 | 1 | 1 |
| gsk2194069 | Homo sapiens (human) | IC50 | 0.0077 | 1 | 1 |
| thiolactomycin | Homo sapiens (human) | IC50 | 240.0000 | 2 | 2 |
This protein enables 16 target(s):
| Target | Category | Definition |
|---|---|---|
| RNA binding | molecular function | Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah] |
| [acyl-carrier-protein] S-acetyltransferase activity | molecular function | Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]. [RHEA:41788] |
| [acyl-carrier-protein] S-malonyltransferase activity | molecular function | Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]. [EC:2.3.1.39] |
| 3-oxoacyl-[acyl-carrier-protein] synthase activity | molecular function | Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. [RHEA:22836] |
| 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity | molecular function | Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. [RHEA:17397] |
| (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity | molecular function | Catalysis of the reaction: (3R)-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O. [PMID:8088535, RHEA:41908] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| (3R)-3-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity | molecular function | Catalysis of the reaction: (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = tetradecenoyl-[acyl-carrier protein] + H2O. [GOC:ai, PMID:12368867, RHEA:41892] |
| (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity | molecular function | Catalysis of the reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl-carrier protein] + H2O. [PMID:8910376, RHEA:41860] |
| fatty acyl-[ACP] hydrolase activity | molecular function | Catalysis of the reaction: a fatty acyl-[ACP] + H2O = a fatty acid + H+ + holo-[acyl-carrier protein]. [RHEA:44596] |
| phosphopantetheine binding | molecular function | Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate). [GOC:mah, GOC:vw] |
| cadherin binding | molecular function | Binding to cadherin, a type I membrane protein involved in cell adhesion. [GOC:bf] |
| (3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity | molecular function | Catalysis of the reaction: (3R)-hydroxybutanoyl-[acyl-carrier-protein] = (2E)-butenoyl-[acyl-carrier-protein] + H2O. [RHEA:41808] |
| (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity | molecular function | Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + (2E)-octenoyl-[acyl-carrier protein]. [PMID:8910376, RHEA:41844] |
| enoyl-[acyl-carrier-protein] reductase (NADPH) activity | molecular function | Catalysis of the reaction: a 2,3-saturated acyl-[ACP] + NADP+ = a (2E)-enoyl-[ACP] + H+ + NADPH. [RHEA:22564] |
| fatty acid synthase activity | molecular function | Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. [EC:2.3.1.85] |
This protein is located in 7 target(s):
| Target | Category | Definition |
|---|---|---|
| Golgi apparatus | cellular component | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| melanosome | cellular component | A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. [GOC:jl, PMID:11584301] |
| glycogen granule | cellular component | Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface. [GOC:jl, PMID:12179957] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
This protein is involved in 12 target(s):
| Target | Category | Definition |
|---|---|---|
| osteoblast differentiation | biological process | The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone. [CL:0000062, GO_REF:0000034, GOC:jid] |
| glandular epithelial cell development | biological process | The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. [GOC:dph] |
| fatty acid metabolic process | biological process | The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198547684] |
| fatty acid biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. [GOC:mah, ISBN:0198506732] |
| inflammatory response | biological process | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732] |
| ether lipid biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol. [GOC:ma, ISBN:0198547684, PMID:15337120] |
| neutrophil differentiation | biological process | The process in which a myeloid precursor cell acquires the specialized features of a neutrophil. [GOC:mah] |
| monocyte differentiation | biological process | The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. [GOC:mah] |
| mammary gland development | biological process | The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages. [PMID:9576833] |
| modulation by host of viral process | biological process | A process in which a host organism modulates the frequency, rate or extent of any of a process being mediated by a virus with which it is infected. [GOC:jl] |
| cellular response to interleukin-4 | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. [GOC:mah] |
| establishment of endothelial intestinal barrier | biological process | The establishment of a barrier between endothelial cell layers of the intestine to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. [GOC:krc, PMID:22155109] |