Corilagin is a hydrolyzable tannin, a type of polyphenol, found in various plants, particularly in the Rubiaceae family. It is composed of two glucose molecules linked to gallic acid and ellagic acid. Corilagin is synthesized through a complex process involving the condensation of gallic acid and ellagic acid with glucose. Research suggests that corilagin exhibits a range of biological activities, including antioxidant, anti-inflammatory, anti-cancer, and anti-diabetic effects. Corilagin is studied for its potential therapeutic applications in various diseases. Its antioxidant properties make it a promising candidate for protecting cells from damage caused by free radicals. Additionally, its anti-inflammatory effects have shown potential in treating conditions like arthritis and inflammatory bowel disease. The anticancer activity of corilagin has been demonstrated in several studies, suggesting its potential role in inhibiting tumor growth and metastasis. Its anti-diabetic effects are attributed to its ability to regulate blood glucose levels. However, further research is needed to fully understand the mechanisms of action and potential therapeutic applications of corilagin in human health.'
corilagin: isolated from Geranii herba [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
corilagin : An ellagitannin with a hexahydroxydiphenoyl group bridging over the 3-O and 6-O of the glucose core. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 73568 |
| CHEMBL ID | 449392 |
| CHEBI ID | 3884 |
| SCHEMBL ID | 329080 |
| MeSH ID | M0140839 |
| Synonym |
|---|
| .beta.-d-glucopyranose, cyclic 3,6-[(1r)-(4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate] 1-(3,4,5-trihydroxybenzoate) |
| corilagin |
| bdbm50242279 |
| 6,7,8,11,12,13,22,23-octahydroxy-3,16-dioxo-21-(3,4,5-trihydroxyphenylcarbonyloxy)-2,17,20-trioxatetracyclo[17.3.1.04,9.010,15]tricosa-4,6,8,10,12,14-hexaene |
| 6,7,8,11,12,13,22,23-octahydroxy-3,16-dioxo-21-(3,4,5-trihydroxyphenylcarbonyloxy)-2,17,20-trioxatetracyclo[17.3.1.04,9.010,15]tricosa-4(9),5,7,10(15),11,13-hexaene |
| CHEMBL449392 , |
| (beta-1-o-galloyl-3,6-(r)-hexahydroxydiphenoyl-d-glucose) |
| CHEBI:3884 , |
| 1-o-galloyl-3,6-hexahydroxydiphenic acid-beta-d-glucopyranose |
| 3-o,6-o-[carbonyl(4,4',5,5',6,6'-hexahydroxybiphenyl-2,2'-diyl)carbonyl]-1-o-(3,4,5-trihydroxybenzoyl)-beta-d-glucopyranose |
| S9090 |
| AKOS015896840 |
| SCHEMBL329080 |
| Q-100295 |
| mfcd00238565 |
| (1s,19r,21s,22r,23r)-6,7,8,11,12,13,22,23-octahydroxy-3,16-dioxo-2,17,20-trioxatetracyclo[17.3.1.0^{4,9}.0^{10,15}]tricosa-4,6,8,10,12,14-hexaen-21-yl 3,4,5-trihydroxybenzoate |
| corilagin, analytical standard |
| corillagin |
| corilagin,(s) |
| Q909822 |
| CCG-270295 |
| [(1s,19r,21s,22r,23r)-6,7,8,11,12,13,22,23-octahydroxy-3,16-dioxo-2,17,20-trioxatetracyclo[17.3.1.04,9.010,15]tricosa-4,6,8,10,12,14-hexaen-21-yl] 3,4,5-trihydroxybenzoate |
| 2088321-44-0 |
| beta-d-glucopyranose, cyclic 3,6-(4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate) 1-(3,4,5-trihydroxybenzoate) |
| DTXSID301104707 |
| np-004255 |
| GLXC-20959 |
Corilagin is a naturally occurring water-soluble retrogallic acid tannin, which can be extracted from many kinds of plants. Corilagin has been identified anti-inflammatory properties. It may be an ideal complimentary medicine when combined with highly toxic chemotherapeutic agents.
Corilagin (Cori) has been reported to exhibit strong anti-inflammatory property. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.
Corilagin treatment significantly reduced the degree of injury in the common carotid artery and decreased the number of lipid plaques and foam cells. Corilagin could reduce the cardiotoxicity enzymes and biomarkers in serum.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Corilagin treatment significantly reduced the degree of injury in the common carotid artery and decreased the number of lipid plaques and foam cells." | ( Corilagin ameliorates atherosclerosis by regulating MMP-1, -2, and -9 expression in vitro and in vivo. Chen, P; He, B; Hu, Q; Jin, H; Shen, Z; Tao, Y; Yang, R; Yang, Y; Zhang, L; Zhang, X, 2021) | 2.79 |
| "Corilagin treatment reverted the cardiac histology to near normal." | ( Cardioprotective effects of corilagin on doxorubicin induced cardiotoxicity via P13K/Akt and NF-κB signaling pathways in a rat model. Gong, X; Huang, J; Lei, S; Lei, Y, 2022) | 1.74 |
| "Upon treatment, corilagin could reduce the cardiotoxicity enzymes and biomarkers in serum." | ( Cardioprotective effects of corilagin on doxorubicin induced cardiotoxicity via P13K/Akt and NF-κB signaling pathways in a rat model. Gong, X; Huang, J; Lei, S; Lei, Y, 2022) | 1.35 |
| "Treatment with corilagin significantly increases the activity of superoxide dismutase (SOD) and level of adenosine triphosphate (ATP) and decreases the level of MDA in the tissue homogenate of I/R induced lung injury model." | ( Corilagin protects the acute lung injury by ameliorating the apoptosis pathway. Fu, Y; Guo, S; Lv, J; Xiong, S, 2017) | 2.24 |
| "Treatment with corilagin significantly protects the degranulation of mast cells, and it also has significant anti-muscarinic and antihistaminic activity by reducing the muscle contraction induced by Acetylcholine (Ach) and histamine in guinea pig tracheal chain and ileum." | ( Corilagin Attenuates Allergy and Anaphylactic Reaction by Inhibiting Degranulation of Mast Cells. Li, F; Mao, W; Sun, Y; Wang, L; Zhang, C; Zhang, J; Zhou, J, 2018) | 2.26 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " An adverse event of cardiotoxicity is the main deem to restrict in the clinical application by oncologists." | ( An in vivo and in vitro model on the protective effect of corilagin on doxorubicin-induced cardiotoxicity via regulation of apoptosis and PI3-K/AKT signaling pathways. Ding, L; Govindhan, A; Li, D; Li, M; Santhoshkumar, M; Xiang, H; Zhao, D, 2021) | 0.87 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " Oral bioavailability of corilagin was calculated to be 10." | ( Development and validation of an UPLC-PDA method for the determination of corilagin in rat plasma and its application to pharmacokinetic study. Chen, D; Igo, LP; Li, Z; Xiang, Z; Yang, X; Ye, X; Zheng, B, 2016) | 0.97 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " Furthermore, analysis of enzymes markers of liver function, including alanine aminotransferase and asparate aminotransferase, suggested that current therapeutic dosage of corilagin did not exert adverse effect on liver." | ( In vivo anti-tumour activity of corilagin on Hep3B hepatocellular carcinoma. Chan, KW; Cheng, CH; Cheng, GY; Cheung, F; Chui, CH; Fong, DW; Gambari, R; Hau, DK; Lai, PB; Lam, KH; Lau, FY; Leung, AK; Tong, SW; Wong, RS; Wong, WY; Zhu, GY, 2010) | 0.84 |
| " It can be further studied for optimum dosage to be used as a future of anti-anxiety drug development or as a standardized Phytomedicine." | ( An Insight Into the Anxiolytic Effects of Lignans (Phyllanthin and Hypophyllanthin) and Tannin (Corilagin) Rich Extracts of Chopade, AR; Dharanguttikar, VR; Dias, RJ; Mali, SN; Naikwade, NS; Patil, PA; Pol, RP, 2021) | 0.84 |
| Role | Description |
|---|---|
| antihypertensive agent | Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. |
| EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor | An EC 3.4.15.* (peptidyl-dipeptidase) inhibitor that interferes with the action of peptidyl-dipeptidase A (EC 3.4.15.1). |
| non-steroidal anti-inflammatory drug | An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. |
| antioxidant | A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| ellagitannin | A form of hydrolysable tannin produced from ellagic acid. Ellagitannins are glucosides which are readily hydrolysed by water to regenerate ellagic acid when the plants are eaten. |
| gallate ester | A benzoate ester that is any ester resulting from the formal condensation of the carboxy group of gallic acid (3,4,5-trihydroxybenzoic acid) with an alcoholic or phenolic hydroxy group. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Protein kinase C alpha type | Rattus norvegicus (Norway rat) | IC50 (µMol) | 20.0000 | 0.0000 | 0.2193 | 1.0000 | AID165112 |
| Protein kinase C delta type | Rattus norvegicus (Norway rat) | IC50 (µMol) | 20.0000 | 0.0000 | 0.2585 | 1.0000 | AID165112 |
| Protein kinase C epsilon type | Rattus norvegicus (Norway rat) | IC50 (µMol) | 20.0000 | 0.0000 | 0.2585 | 1.0000 | AID165112 |
| Protein kinase C zeta type | Rattus norvegicus (Norway rat) | IC50 (µMol) | 20.0000 | 0.0000 | 0.2585 | 1.0000 | AID165112 |
| DNA topoisomerase 1 | Homo sapiens (human) | IC50 (µMol) | 40.0000 | 0.0210 | 1.8626 | 10.0000 | AID334464 |
| Angiotensin-converting enzyme | Homo sapiens (human) | IC50 (µMol) | 3,700.0000 | 0.0001 | 0.5336 | 10.0000 | AID338980 |
| DNA repair protein RAD52 homolog | Homo sapiens (human) | IC50 (µMol) | 1.0000 | 0.2550 | 2.6301 | 6.7000 | AID1639797; AID1639798 |
| Squalene monooxygenase | Rattus norvegicus (Norway rat) | IC50 (µMol) | 4.0000 | 0.0610 | 2.3446 | 10.0000 | AID357307 |
| Protein kinase C gamma type | Rattus norvegicus (Norway rat) | IC50 (µMol) | 20.0000 | 0.0000 | 0.2640 | 1.1000 | AID165112 |
| Protein kinase C beta type | Rattus norvegicus (Norway rat) | IC50 (µMol) | 20.0000 | 0.0000 | 0.2164 | 1.1000 | AID165112 |
| Protein kinase C eta type | Rattus norvegicus (Norway rat) | IC50 (µMol) | 20.0000 | 0.0000 | 0.2585 | 1.0000 | AID165112 |
| RNA-directed RNA polymerase | IC50 (µMol) | 20.0000 | 0.0190 | 2.5279 | 8.8000 | AID1882599 | |
| Protein kinase C theta type | Rattus norvegicus (Norway rat) | IC50 (µMol) | 20.0000 | 0.0000 | 0.2585 | 1.0000 | AID165112 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID400985 | Inhibition of AMV reverse transcriptase activity assessed as incorporation of dTMP in poly(rA)-oligo(dT) at 1 uM | |||
| AID1678475 | Potency index, ratio of trolox IC50 to test compound IC50 for antioxidant activity assessed as DPPH radical scavenging activity | 2020 | ACS medicinal chemistry letters, Nov-12, Volume: 11, Issue:11 | Covalent Bridging of Corilagin Improves Antiferroptosis Activity: Comparison with 1,3,6-Tri- |
| AID338980 | Inhibition of ACE by fluorometric assay | |||
| AID400986 | Inhibition of AMV reverse transcriptase activity assessed as incorporation of dTMP in poly(rA)-oligo(dT) at 10 uM | |||
| AID641104 | Antiviral activity against Hepatitis C virus infected in human Huh7.5 cells assessed as inhibition of viral replication after 96 hrs by quantitative RT-PCR analysis | 2012 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 22, Issue:2 | Inhibitory effects of polyphenols toward HCV from the mangrove plant Excoecaria agallocha L. |
| AID1678473 | Antioxidant activity assessed as ferric ion reducing activity using FeCl3.H2O and TPTZ incubated for 30 mins by FRAP assay | 2020 | ACS medicinal chemistry letters, Nov-12, Volume: 11, Issue:11 | Covalent Bridging of Corilagin Improves Antiferroptosis Activity: Comparison with 1,3,6-Tri- |
| AID1917353 | Inhibition of Bacillus subtilis RuvA/RuvB protein complex helicase activity expressed in Escherichia coli BL21(DE3) assessed as inhibition of HJ branch migration preincubated for 15 mins followed by substrate addition and measured after 1 hr using 5'-FAM | 2022 | Bioorganic & medicinal chemistry, 11-01, Volume: 73 | Identification of small-molecule inhibitors of the DNA repair proteins RuvAB from Pseudomonas aeruginosa. |
| AID641102 | Inhibition of Hepatitic C virus NS3/4A protease by FRET assay | 2012 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 22, Issue:2 | Inhibitory effects of polyphenols toward HCV from the mangrove plant Excoecaria agallocha L. |
| AID1058210 | Antiulcerative colitis activity in ip dosed C57BL/6 mouse assessed as inhibition of DSS-induced shortening of colon length administered qd on day 6 to 12 post DSS-challenge measured on day 13 | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Inhibitory effect of the gallotannin corilagin on dextran sulfate sodium-induced murine ulcerative colitis. |
| AID400988 | Inhibition of AMV reverse transcriptase activity assessed as incorporation of dTMP in poly(rA)-oligo(dT) at 1000 uM | |||
| AID1917352 | Inhibition of Pseudomonas aeruginosa RuvA/RuvB protein complex helicase activity expressed in Escherichia coli BL21(DE3) assessed as inhibition of HJ branch migration preincubated for 15 mins followed by substrate addition and measured after 1 hr using 5' | 2022 | Bioorganic & medicinal chemistry, 11-01, Volume: 73 | Identification of small-molecule inhibitors of the DNA repair proteins RuvAB from Pseudomonas aeruginosa. |
| AID1678474 | Antioxidant activity assessed as DPPH free radical scavenging activity after 5 mins by microplate reader based assay | 2020 | ACS medicinal chemistry letters, Nov-12, Volume: 11, Issue:11 | Covalent Bridging of Corilagin Improves Antiferroptosis Activity: Comparison with 1,3,6-Tri- |
| AID1678472 | Antioxidant activity in pH 4.5 phosphate buffer assessed as PTIO radical scavenging activity after 1 hr by microplate reader based assay | 2020 | ACS medicinal chemistry letters, Nov-12, Volume: 11, Issue:11 | Covalent Bridging of Corilagin Improves Antiferroptosis Activity: Comparison with 1,3,6-Tri- |
| AID1126477 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha secretion at 0.4 uM after 18 hrs by sandwich ELISA | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Anti-inflammatory components of Euphorbia humifusa Willd. |
| AID1126473 | Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 50 uM after 18 hrs by MTT assay in presence of LPS | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Anti-inflammatory components of Euphorbia humifusa Willd. |
| AID641105 | Cytotoxicity against human Huh7.5 cells after 96 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 22, Issue:2 | Inhibitory effects of polyphenols toward HCV from the mangrove plant Excoecaria agallocha L. |
| AID358167 | Cytotoxicity against human A549 cells by tetrazolium salt-based colorimetric assay | 1992 | Journal of natural products, Aug, Volume: 55, Issue:8 | Antitumor agents, 129. Tannins and related compounds as selective cytotoxic agents. |
| AID1126479 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha secretion after 18 hrs by sandwich ELISA | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Anti-inflammatory components of Euphorbia humifusa Willd. |
| AID357307 | Inhibition of C-terminal hexahistidine-tagged rat recombinant squalene epoxidase without N-terminal putative membrane domain expressed in Escherichia coli | 2001 | Journal of natural products, Aug, Volume: 64, Issue:8 | Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. |
| AID358165 | Cytotoxicity against human PRMI7951 cells by tetrazolium salt-based colorimetric assay | 1992 | Journal of natural products, Aug, Volume: 55, Issue:8 | Antitumor agents, 129. Tannins and related compounds as selective cytotoxic agents. |
| AID1882599 | Inhibition of Hepatitis C virus NS5B RNA-dependent-RNA-polymerase | 2022 | Bioorganic & medicinal chemistry, 04-15, Volume: 60 | Recent advancement in small molecules as HCV inhibitors. |
| AID1917364 | Binding affinity to CM5 chip immobilized Pseudomonas aeruginosa RuvB D114N mutant expressed in Escherichia coli BL21(DE3) assessed as dissociation constant measured for 180 sec by surface plasmon resonance analysis | 2022 | Bioorganic & medicinal chemistry, 11-01, Volume: 73 | Identification of small-molecule inhibitors of the DNA repair proteins RuvAB from Pseudomonas aeruginosa. |
| AID641103 | Selectivity index, ratio of CC50 for human Huh7.5 cells to EC50 for Hepatitis C virus infected in human HuH7.5 cells | 2012 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 22, Issue:2 | Inhibitory effects of polyphenols toward HCV from the mangrove plant Excoecaria agallocha L. |
| AID1110810 | Antimicrobial activity against Pectobacterium carotovorum at 100 ug after 24 hr by disk diffusion method | 2005 | Phytochemistry, Jan, Volume: 66, Issue:2 | Bioactive ellagitannins from Cunonia macrophylla, an endemic Cunoniaceae from New Caledonia. |
| AID1058213 | Antiulcerative colitis activity in C57BL/6 mouse assessed as attenuation of DSS-induced inflammatory cell infiltration at 7.5 to 30 mg/kg, ip qd administered on day 6 to 12 post DSS-challenge measured on day 13 by hematoxylin/eosin staining-based assay | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Inhibitory effect of the gallotannin corilagin on dextran sulfate sodium-induced murine ulcerative colitis. |
| AID1873812 | Inhibition of amyloid beta 1 to 42 aggregation (unknown origin) incubated for 24 hrs by ThT fluorescence assay relative to control | 2022 | Bioorganic & medicinal chemistry, 08-15, Volume: 68 | Chemical analysis of amyloid β aggregation inhibitors derived from Geranium thunbergii. |
| AID358169 | Cytotoxicity against human TE671 cells by tetrazolium salt-based colorimetric assay | 1992 | Journal of natural products, Aug, Volume: 55, Issue:8 | Antitumor agents, 129. Tannins and related compounds as selective cytotoxic agents. |
| AID1058198 | Antiulcerative colitis activity in C57BL/6 mouse assessed as recovery of DSS-induced body weight loss at 7.5 to 30 mg/kg, ip qd administered on day 6 to 12 post DSS-challenge measured on day 9 | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Inhibitory effect of the gallotannin corilagin on dextran sulfate sodium-induced murine ulcerative colitis. |
| AID1917360 | Binding affinity to CM5 chip immobilized Pseudomonas aeruginosa wild type RuvB expressed in Escherichia coli BL21(DE3) assessed as dissociation rate constant (kd) measured for 180 sec by surface plasmon resonance analysis | 2022 | Bioorganic & medicinal chemistry, 11-01, Volume: 73 | Identification of small-molecule inhibitors of the DNA repair proteins RuvAB from Pseudomonas aeruginosa. |
| AID1873810 | Inhibition of amyloid beta 1 to 42 aggregation (unknown origin) incubated for 24 hrs by inverted fluorescence microscopic analysis relative to control | 2022 | Bioorganic & medicinal chemistry, 08-15, Volume: 68 | Chemical analysis of amyloid β aggregation inhibitors derived from Geranium thunbergii. |
| AID1917354 | Inhibition of Thermus thermophilus RuvA/RuvB protein complex helicase activity expressed in Escherichia coli BL21(DE3) assessed as inhibition of HJ branch migration preincubated for 15 mins followed by substrate addition and measured after 1 hr using 5'-F | 2022 | Bioorganic & medicinal chemistry, 11-01, Volume: 73 | Identification of small-molecule inhibitors of the DNA repair proteins RuvAB from Pseudomonas aeruginosa. |
| AID1678470 | Metal chelating activity assessed as Fe2+-compound complex formation incubated for 5 mins by colorimetry | 2020 | ACS medicinal chemistry letters, Nov-12, Volume: 11, Issue:11 | Covalent Bridging of Corilagin Improves Antiferroptosis Activity: Comparison with 1,3,6-Tri- |
| AID400993 | Inhibition of AMV reverse transcriptase activity assessed as incorporation of dGMP in poly(rC)-oligo(dG) at 1000 uM | |||
| AID1678466 | Anti-ferroptosis activity against erastin-induced ferroptosis in Sprague-Dawley rat bmMSC cells assessed as cellular death at 4.7 uM after 1 hr by AnnexinV-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 3.73%) | 2020 | ACS medicinal chemistry letters, Nov-12, Volume: 11, Issue:11 | Covalent Bridging of Corilagin Improves Antiferroptosis Activity: Comparison with 1,3,6-Tri- |
| AID1126475 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production at 0.4 uM after 18 hrs by griess reaction analysis | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Anti-inflammatory components of Euphorbia humifusa Willd. |
| AID1058206 | In vivo inhibition of myeloperoxidase activity in colon homogenates of DSS-induced acute colitis C57BL/6 mouse model at 7.5 to 30 mg/kg, ip qd administered on day 6 to 12 post DSS-challenge measured on day 13 | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Inhibitory effect of the gallotannin corilagin on dextran sulfate sodium-induced murine ulcerative colitis. |
| AID165112 | Inhibitory activity against protein kinase C of rat brain | 1994 | Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1 | New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C. |
| AID1678465 | Anti-ferroptosis activity against erastin-induced ferroptosis in Sprague-Dawley rat bmMSC cells assessed as inhibition of lipid peroxidation at 3 ug/ml preincubated for 12 hrs followed by compound addition and measured after 12 hrs by C11-Bodipy fluoresce | 2020 | ACS medicinal chemistry letters, Nov-12, Volume: 11, Issue:11 | Covalent Bridging of Corilagin Improves Antiferroptosis Activity: Comparison with 1,3,6-Tri- |
| AID1126478 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 18 hrs by griess reaction analysis | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Anti-inflammatory components of Euphorbia humifusa Willd. |
| AID1058209 | Antiulcerative colitis activity in C57BL/6 mouse assessed as inhibition of DSS-induced shortening of colon length at 30 mg/kg, ip qd administered on day 6 to 12 post DSS-challenge measured on day 13 | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Inhibitory effect of the gallotannin corilagin on dextran sulfate sodium-induced murine ulcerative colitis. |
| AID1058201 | Antiinflammatory activity in DSS-induced acute colitis C57BL/6 mouse model assessed as upregulation of IkappaB-alpha protein expression at 15 to 30 mg/kg, ip qd administered on day 6 to 12 post DSS-challenge measured on day 13 by Western blotting analysis | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Inhibitory effect of the gallotannin corilagin on dextran sulfate sodium-induced murine ulcerative colitis. |
| AID1678471 | Antioxidant activity in pH 7.4 phosphate buffer assessed as PTIO radical scavenging activity after 1 hr by microplate reader based assay | 2020 | ACS medicinal chemistry letters, Nov-12, Volume: 11, Issue:11 | Covalent Bridging of Corilagin Improves Antiferroptosis Activity: Comparison with 1,3,6-Tri- |
| AID1058202 | Antiinflammatory activity in DSS-treated C57BL/6 mouse assessed as effect on IL-10 production in colon at 7.5 to 30 mg/kg, ip qd administered on day 6 to 12 post DSS-challenge measured on day 13 by ELISA | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Inhibitory effect of the gallotannin corilagin on dextran sulfate sodium-induced murine ulcerative colitis. |
| AID358166 | Cytotoxicity against human KB cells by tetrazolium salt-based colorimetric assay | 1992 | Journal of natural products, Aug, Volume: 55, Issue:8 | Antitumor agents, 129. Tannins and related compounds as selective cytotoxic agents. |
| AID1110808 | Antimicrobial activity against Corynebacterium accolens at 100 ug after 24 hr by disk diffusion method | 2005 | Phytochemistry, Jan, Volume: 66, Issue:2 | Bioactive ellagitannins from Cunonia macrophylla, an endemic Cunoniaceae from New Caledonia. |
| AID1678477 | Metal chelating activity assessed as Fe2+-compound complex formation by measuring red shift by UV-visible spectrophotometry | 2020 | ACS medicinal chemistry letters, Nov-12, Volume: 11, Issue:11 | Covalent Bridging of Corilagin Improves Antiferroptosis Activity: Comparison with 1,3,6-Tri- |
| AID400992 | Inhibition of AMV reverse transcriptase activity assessed as incorporation of dGMP in poly(rC)-oligo(dG) at 100 uM | |||
| AID400987 | Inhibition of AMV reverse transcriptase activity assessed as incorporation of dTMP in poly(rA)-oligo(dT) at 100 uM | |||
| AID1126471 | Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis at 25 uM after 1 hr by fluorescence method | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Anti-inflammatory components of Euphorbia humifusa Willd. |
| AID400989 | Inhibition of AMV reverse transcriptase activity assessed as incorporation of dGMP in poly(rC)-oligo(dG) at 0.1 uM | |||
| AID1873811 | Inhibition of amyloid beta 1 to 42 aggregation (unknown origin) incubated for 24 hrs by ThT fluorescence assay | 2022 | Bioorganic & medicinal chemistry, 08-15, Volume: 68 | Chemical analysis of amyloid β aggregation inhibitors derived from Geranium thunbergii. |
| AID1917359 | Binding affinity to CM5 chip immobilized Pseudomonas aeruginosa wild type RuvB expressed in Escherichia coli BL21(DE3) assessed as association rate constant (ka) measured for 240 sec by surface plasmon resonance analysis | 2022 | Bioorganic & medicinal chemistry, 11-01, Volume: 73 | Identification of small-molecule inhibitors of the DNA repair proteins RuvAB from Pseudomonas aeruginosa. |
| AID1058212 | Antiulcerative colitis activity in DSS-induced acute colitis C57BL/6 mouse model assessed as decrease in disease activity index at 15 to 30 mg/kg, ip qd administered on day 6 to 12 post DSS-challenge measured on day 13 | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Inhibitory effect of the gallotannin corilagin on dextran sulfate sodium-induced murine ulcerative colitis. |
| AID1678469 | Anti-ferroptosis activity against erastin-induced ferroptosis in Spargue-Dawley rat bmMSCs cells assessed as cell viability at 4.7 uM after 1 hr by AnnexinV-FITC/propidium iodide staining based flow cytometry analysis (Rvb = 65.9%) | 2020 | ACS medicinal chemistry letters, Nov-12, Volume: 11, Issue:11 | Covalent Bridging of Corilagin Improves Antiferroptosis Activity: Comparison with 1,3,6-Tri- |
| AID1917370 | Antimicrobial activity against Pseudomonas aeruginosa ATCC27853 assessed as colony formation at 50 uM preincubated for 1 hr followed by UV-light irradiation for 5 mins then culture on LB-agar plate for overnight by colony counting method | 2022 | Bioorganic & medicinal chemistry, 11-01, Volume: 73 | Identification of small-molecule inhibitors of the DNA repair proteins RuvAB from Pseudomonas aeruginosa. |
| AID1058207 | Antiulcerative colitis activity in C57BL/6 mouse assessed as attenuation of DSS-induced lesions formation at 7.5 to 30 mg/kg, ip qd administered on day 6 to 12 post DSS-challenge measured on day 13 by hematoxylin/eosin staining-based assay | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Inhibitory effect of the gallotannin corilagin on dextran sulfate sodium-induced murine ulcerative colitis. |
| AID400990 | Inhibition of AMV reverse transcriptase activity assessed as incorporation of dGMP in poly(rC)-oligo(dG) at 1 uM | |||
| AID334464 | Inhibition of human COLO201 cellular topoisomerase-1 mediated plasmid DNA cleavage by electrophoresis in presence of 70 units of enzyme | 1992 | Journal of natural products, Apr, Volume: 55, Issue:4 | A strategy for identifying novel, mechanistically unique inhibitors of topoisomerase I. |
| AID1058203 | Antiinflammatory activity in ip dosed C57BL/6 mouse assessed as reduction of DSS-induced IL-6 production in colon administered qd on day 6 to 12 post DSS-challenge measured on day 13 by ELISA | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Inhibitory effect of the gallotannin corilagin on dextran sulfate sodium-induced murine ulcerative colitis. |
| AID1917362 | Binding affinity to CM5 chip immobilized Pseudomonas aeruginosa RuvB D114N mutant expressed in Escherichia coli BL21(DE3) assessed as association rate constant (ka) measured for 240 sec by surface plasmon resonance analysis | 2022 | Bioorganic & medicinal chemistry, 11-01, Volume: 73 | Identification of small-molecule inhibitors of the DNA repair proteins RuvAB from Pseudomonas aeruginosa. |
| AID1882598 | Inhibition of Hepatitis C virus NS3 protease | 2022 | Bioorganic & medicinal chemistry, 04-15, Volume: 60 | Recent advancement in small molecules as HCV inhibitors. |
| AID1678467 | Anti-ferroptosis activity against erastin-induced ferroptosis in Sprague-Dawley rat bmMSC cells assessed as late cell death at 4.7 uM after 1 hr by AnnexinV-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 19.9%) | 2020 | ACS medicinal chemistry letters, Nov-12, Volume: 11, Issue:11 | Covalent Bridging of Corilagin Improves Antiferroptosis Activity: Comparison with 1,3,6-Tri- |
| AID1678468 | Anti-ferroptosis activity against erastin-induced ferroptosis in Sprague-Dawley rat bmMSC cells assessed as early cell death at 4.7 uM after 1 hr by AnnexinV-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 10.4%) | 2020 | ACS medicinal chemistry letters, Nov-12, Volume: 11, Issue:11 | Covalent Bridging of Corilagin Improves Antiferroptosis Activity: Comparison with 1,3,6-Tri- |
| AID1058208 | Antiulcerative colitis activity in C57BL/6 mouse assessed as attenuation of DSS-induced crypt destruction at 7.5 to 30 mg/kg, ip qd administered on day 6 to 12 post DSS-challenge measured on day 13 by hematoxylin/eosin staining-based assay | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Inhibitory effect of the gallotannin corilagin on dextran sulfate sodium-induced murine ulcerative colitis. |
| AID1126474 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production at 10 uM after 18 hrs by griess reaction analysis | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Anti-inflammatory components of Euphorbia humifusa Willd. |
| AID1110809 | Antimicrobial activity against Staphylococcus aureus at 100 ug after 24 hr by disk diffusion method | 2005 | Phytochemistry, Jan, Volume: 66, Issue:2 | Bioactive ellagitannins from Cunonia macrophylla, an endemic Cunoniaceae from New Caledonia. |
| AID1058199 | Antiapoptotic activity in C57BL/6 mouse assessed as reduction of DSS-induced cleaved caspase-9 level in colon at 7.5 to 30 mg/kg, ip qd administered on day 6 to 12 post DSS-challenge measured on day 13 by Western blotting analysis | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Inhibitory effect of the gallotannin corilagin on dextran sulfate sodium-induced murine ulcerative colitis. |
| AID1058205 | Antiinflammatory activity in ip dosed C57BL/6 mouse assessed as reduction of DSS-induced TNF-alpha production in colon administered qd on day 6 to 12 post DSS-challenge measured on day 13 by ELISA | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Inhibitory effect of the gallotannin corilagin on dextran sulfate sodium-induced murine ulcerative colitis. |
| AID1058204 | Antiinflammatory activity in ip dosed C57BL/6 mouse assessed as reduction of DSS-induced IL-1beta production in colon administered qd on day 6 to 12 post DSS-challenge measured on day 13 by ELISA | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Inhibitory effect of the gallotannin corilagin on dextran sulfate sodium-induced murine ulcerative colitis. |
| AID1678476 | Antioxidant activity assessed as compound-DPPH adduct formation with covalent bridging by UHPLC-ESI-Q-TOF-MS analysis | 2020 | ACS medicinal chemistry letters, Nov-12, Volume: 11, Issue:11 | Covalent Bridging of Corilagin Improves Antiferroptosis Activity: Comparison with 1,3,6-Tri- |
| AID1873809 | Inhibition of amyloid beta 1 to 42 aggregation (unknown origin) incubated for 24 hrs by inverted fluorescence microscopic analysis | 2022 | Bioorganic & medicinal chemistry, 08-15, Volume: 68 | Chemical analysis of amyloid β aggregation inhibitors derived from Geranium thunbergii. |
| AID1917357 | Inhibition of HJ-DNA dependent Pseudomonas aeruginosa RuvB ATPase activity expressed in Escherichia coli BL21(DE3) assessed as inhibition of ATP hydrolysis preincubated with compound followed by ATP addition and measured after 1 hr by Kinase-Glo reagent b | 2022 | Bioorganic & medicinal chemistry, 11-01, Volume: 73 | Identification of small-molecule inhibitors of the DNA repair proteins RuvAB from Pseudomonas aeruginosa. |
| AID1110806 | Inhibition of xanthine oxidase assessed as conversion of xanthine to uric acid incubated for 3 min | 2005 | Phytochemistry, Jan, Volume: 66, Issue:2 | Bioactive ellagitannins from Cunonia macrophylla, an endemic Cunoniaceae from New Caledonia. |
| AID1678464 | Anti-ferroptosis activity against erastin-induced ferroptosis in Sprague-Dawley rat bmMSC cells assessed as increase in cell viability at 0.47 to 4.7 uM preincubated for 12 hrs followed by compound addition and measured after 12 hrs by CCK8 assay | 2020 | ACS medicinal chemistry letters, Nov-12, Volume: 11, Issue:11 | Covalent Bridging of Corilagin Improves Antiferroptosis Activity: Comparison with 1,3,6-Tri- |
| AID1110807 | Antimicrobial activity against Candida albicans at 100 ug after 24 hr by disk diffusion method | 2005 | Phytochemistry, Jan, Volume: 66, Issue:2 | Bioactive ellagitannins from Cunonia macrophylla, an endemic Cunoniaceae from New Caledonia. |
| AID358168 | Cytotoxicity against human HCT8 cells by tetrazolium salt-based colorimetric assay | 1992 | Journal of natural products, Aug, Volume: 55, Issue:8 | Antitumor agents, 129. Tannins and related compounds as selective cytotoxic agents. |
| AID1917361 | Binding affinity to CM5 chip immobilized Pseudomonas aeruginosa wild type RuvB expressed in Escherichia coli BL21(DE3) assessed as dissociation constant measured for 180 sec by surface plasmon resonance analysis | 2022 | Bioorganic & medicinal chemistry, 11-01, Volume: 73 | Identification of small-molecule inhibitors of the DNA repair proteins RuvAB from Pseudomonas aeruginosa. |
| AID400991 | Inhibition of AMV reverse transcriptase activity assessed as incorporation of dGMP in poly(rC)-oligo(dG) at 10 uM | |||
| AID1126476 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha secretion at 10 uM after 18 hrs by sandwich ELISA | 2014 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 24, Issue:8 | Anti-inflammatory components of Euphorbia humifusa Willd. |
| AID1917365 | Inhibition of Pseudomonas aeruginosa RuvA expressed in Escherichia coli BL21(DE3) binding to HJ DNA assessed as reduction in RuvA-HJ DNA complex formation at 40 uM and measured after 15 mins using 5'-FAM labelled Holliday junction DNA as substrate by EMSA | 2022 | Bioorganic & medicinal chemistry, 11-01, Volume: 73 | Identification of small-molecule inhibitors of the DNA repair proteins RuvAB from Pseudomonas aeruginosa. |
| AID1917368 | Antimicrobial activity against Pseudomonas aeruginosa ATCC27853 assessed as colony formation at 50 uM preincubated for 1 hr then culture on LB-agar plate for overnight by colony counting method | 2022 | Bioorganic & medicinal chemistry, 11-01, Volume: 73 | Identification of small-molecule inhibitors of the DNA repair proteins RuvAB from Pseudomonas aeruginosa. |
| AID400984 | Inhibition of AMV reverse transcriptase activity assessed as incorporation of dTMP in poly(rA)-oligo(dT) at 0.1 uM | |||
| AID1917363 | Binding affinity to CM5 chip immobilized Pseudomonas aeruginosa RuvB D114N mutant expressed in Escherichia coli BL21(DE3) assessed as dissociation rate constant (kd) measured for 180 sec by surface plasmon resonance analysis | 2022 | Bioorganic & medicinal chemistry, 11-01, Volume: 73 | Identification of small-molecule inhibitors of the DNA repair proteins RuvAB from Pseudomonas aeruginosa. |
| AID1058211 | Antiulcerative colitis activity in C57BL/6 mouse assessed as recovery of DSS-induced body weight loss at 7.5 to 30 mg/kg, ip qd administered on day 6 to 12 post DSS-challenge measured on day 8 | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Inhibitory effect of the gallotannin corilagin on dextran sulfate sodium-induced murine ulcerative colitis. |
| AID1058200 | Antiapoptotic activity in C57BL/6 mouse assessed as reduction of DSS-induced cleaved caspase-3 level in colon at 7.5 to 30 mg/kg, ip qd administered on day 6 to 12 post DSS-challenge measured on day 13 by Western blotting analysis | 2013 | Journal of natural products, Nov-22, Volume: 76, Issue:11 | Inhibitory effect of the gallotannin corilagin on dextran sulfate sodium-induced murine ulcerative colitis. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (0.68) | 18.7374 |
| 1990's | 5 (3.38) | 18.2507 |
| 2000's | 22 (14.86) | 29.6817 |
| 2010's | 71 (47.97) | 24.3611 |
| 2020's | 49 (33.11) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (37.60) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 6 (3.92%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 147 (96.08%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||