Proteins > Prostaglandin E2 receptor EP4 subtype
Page last updated: 2024-08-07 16:30:02
Prostaglandin E2 receptor EP4 subtype
A prostaglandin E2 receptor EP4 subtype that is encoded in the genome of mouse. [OMA:P32240, PRO:DNx]
Synonyms
PGE receptor EP4 subtype;
PGE2 receptor EP4 subtype;
Prostanoid EP4 receptor
Research
Bioassay Publications (9)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (5)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| indomethacin | Mus musculus (house mouse) | Ki | 10.0000 | 2 | 2 |
| dinoprostone | Mus musculus (house mouse) | Ki | 0.0031 | 2 | 2 |
| alprostadil | Mus musculus (house mouse) | Ki | 0.0032 | 3 | 4 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| alprostadil | Mus musculus (house mouse) | EC50 | 0.0029 | 2 | 3 |
| ono4819 | Mus musculus (house mouse) | EC50 | 0.0016 | 1 | 1 |
| cj-023,423 | Mus musculus (house mouse) | Kd | 0.0078 | 1 | 1 |
Discovery of selective indole-based prostaglandin Dâ‚‚ receptor antagonist.Bioorganic & medicinal chemistry, , Aug-01, Volume: 19, Issue:15, 2011
Discovery of new chemical leads for prostaglandin D2 receptor antagonists.Bioorganic & medicinal chemistry letters, , Sep-06, Volume: 14, Issue:17, 2004
Discovery of novel prostaglandin analogs as potent and selective EP2/EP4 dual agonists.Bioorganic & medicinal chemistry, , Apr-01, Volume: 20, Issue:7, 2012
Discovery of a novel EP2/EP4 dual agonist with high subtype-selectivity.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 22, Issue:1, 2012
Design and synthesis of a highly selective EP4-receptor agonist. Part 2: 5-thia and 9beta-haloPG derivatives with improved stability.Bioorganic & medicinal chemistry letters, , Aug-06, Volume: 11, Issue:15, 2001
Design and synthesis of a highly selective EP2-receptor agonist.Bioorganic & medicinal chemistry letters, , Aug-06, Volume: 11, Issue:15, 2001
Design and synthesis of a highly selective EP4-receptor agonist. Part 1: 3,7-dithiaPG derivatives with high selectivity.Bioorganic & medicinal chemistry letters, , Aug-06, Volume: 11, Issue:15, 2001