trimetrexate has been researched along with Necrosis in 1 studies
Trimetrexate: A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Trimetrexate was administered to rats in an interrupted treatment regimen comparable to proposed human clinical treatment." | 1.28 | Chronic toxicity of the anticancer agent trimetrexate in rats. ( Dethloff, LA; Watkins, JR, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dethloff, LA | 1 |
| Watkins, JR | 1 |
1 other study available for trimetrexate and Necrosis
| Article | Year |
|---|---|
Chronic toxicity of the anticancer agent trimetrexate in rats.
Topics: Animals; Body Weight; Bone Marrow; Bone Marrow Cells; Cecum; Dose-Response Relationship, Drug; Drug | 1992 |