Suppressor of tumorigenicity 14 protein

A suppressor of tumorigenicity 14 protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y5Y6]

Synonyms

EC 3.4.21.109;
Matriptase;
Membrane-type serine protease 1;
MT-SP1;
Prostamin;
Serine protease 14;
Serine protease TADG-15;
Tumor-associated differentially-expressed gene 15 protein

Research

Bioassay Publications (7)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (28.57)	29.6817
2010's	5 (71.43)	24.3611
2020's	0 (0.00)	2.80

Compounds (10)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
benzamidine	Homo sapiens (human)	Ki	400.0000	1	1
nafamostat	Homo sapiens (human)	Ki	0.0000	2	2
pentamidine	Homo sapiens (human)	Ki	1.1600	1	1
dibrompropamidine	Homo sapiens (human)	Ki	0.5350	1	1
hexamidine	Homo sapiens (human)	Ki	0.9240	1	1
leupeptin	Homo sapiens (human)	Ki	1.2980	2	2
n(alpha)-tosyl-(3-amidinophenyl)alanine piperidide	Homo sapiens (human)	Ki	14.0000	1	1
rivaroxaban	Homo sapiens (human)	Ki	3.3500	1	1
n-alpha-(2,4,6-triisopropyl-phenylsulfonyl)-3-amidino-(l)-phenyl-alanine-4-ethoxycarbonyl-piperazide hydrochloride	Homo sapiens (human)	Ki	0.6050	2	6

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
tertiary-butyloxycarbonyl-phenylalanyl-seryl-arginyl-4-methylcoumarin-7-amide	Homo sapiens (human)	Km	12.1000	1	1

Enables

This protein enables 2 target(s):

Target	Category	Definition
serine-type endopeptidase activity	molecular function	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
serine-type peptidase activity	molecular function	Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
external side of plasma membrane	cellular component	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]
basolateral plasma membrane	cellular component	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]

Involved In

This protein is involved in 5 target(s):

Target	Category	Definition
neural tube closure	biological process	The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline. [GOC:dph, ISBN:0878932437]
proteolysis	biological process	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
protein catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. [GOC:mah]
keratinocyte differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte. [GOC:dph, GOC:mah, GOC:sdb_2009, GOC:tb]
epithelial cell morphogenesis involved in placental branching	biological process	The change in form (cell shape and size) that occurs when a trophoblast cell elongates to contribute to the branching of the placenta. [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:16916377]

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