Compounds > acetyldeoxynivalenol

Page last updated: 2024-12-07

acetyldeoxynivalenol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	104759
CHEBI ID	175302
MeSH ID	M0116970

Synonyms (12)

Synonym
7,15-dihydroxy-8-oxo-12,13-epoxytrichothec-9-en-3-yl acetate
CHEBI:175302
acetyldeoxynivalenol
[3-hydroxy-2-(hydroxymethyl)-1,5-dimethyl-4-oxospiro[8-oxatricyclo[7.2.1.02,7]dodec-5-ene-12,2'-oxirane]-10-yl] acetate
wln: t c665 a ax ev io futj b1 c1q dq f1 kov1 lov1u2 a-& bt3ox chj
anguidine deriv 3a,15- dihydroxy-12,13-epoxytrichotec-9-en-8-one
trichothec-9-en-8-one,15-dihydroxy-, (3.alpha.,7.alpha.)-
trichothec-9-en-8-one, 12,13-epoxy-3,7,15-trihydroxy-, monoacetate, (3.alpha.,7.alpha.)-
ADFIQZBYNGPCGY-UHFFFAOYSA-N
115825-62-2
DTXSID50921817
PD044466

Research Excerpts

Toxicity

Excerpt	Reference	Relevance
" The findings indicate that, after an initial period of reduced feed intake, animals are apparently able to overcome the toxic effects of 3-acetyldeoxynivalenol."	( Subacute toxicity of dietary 3-acetyldeoxynivalenol in mice. Blakley, BR; Greenhalgh, R; Hancock, DS; Kasali, OB; Schiefer, HB; Tomar, RS, 1985)	0.76

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
trichothecene	Any one of a large family of chemically related mycotoxins with a structure based on a sesquiterpene skeleton. The most important structural features causing the biological activities of trichothecenes are a 12,13-epoxy ring, the presence of hydroxy or acetyl groups at appropriate positions on the trichothecene nucleus and the structure and position of the side-chain.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (24)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (20.83)	18.7374
1990's	2 (8.33)	18.2507
2000's	6 (25.00)	29.6817
2010's	9 (37.50)	24.3611
2020's	2 (8.33)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 29.93

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	29.93 (24.57)
Research Supply Index	3.30 (2.92)
Research Growth Index	4.87 (4.65)
Search Engine Demand Index	28.68 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (29.93)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (3.85%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	25 (96.15%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
phenol [no description available]	3.35	1	0	phenols	antiseptic drug; disinfectant; human xenobiotic metabolite; mouse metabolite
altenuene altenuene: metabolite of Alternaria; structure given in first source. altenuene : A benzochromenone mycotoxin isolated from the fungus Allernaria tenuis.	2.13	1	0
deoxynivalenol deoxynivalenol : A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.	5.12	14	0	cyclic ketone; enone; primary alcohol; secondary alpha-hydroxy ketone; trichothecene; triol	mycotoxin
moniliformin moniliformin: RN given refers to parent cpd; structure; do not confuse with plant product, moniliformin	7.44	2	0
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	2.08	1	0	D-glucopyranose	epitope; mouse metabolite
verrucarol [no description available]	2.02	1	0
nsc 141537 diacetoxyscirpenol: mycotoxin belonging to 12,13-epoxytrichothecene group; RN given refers to (3alpha,4beta)-isomer; structure	2.02	1	0	trichothecene
nivalenol nivalenol: RN given refers to 3alpha,4beta,7alpha-isomer	3.29	6	0	trichothecene
sesquiterpenes [no description available]	2.88	4	0
zeranol Zeranol: A non-steroidal estrogen analog.	2.38	2	0	macrolide
ovalbumin Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.	2.06	1	0
zearalenone Zearalenone: (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione. One of a group of compounds known under the general designation of resorcylic acid lactones. Cis, trans, dextro and levo forms have been isolated from the fungus Gibberella zeae (formerly Fusarium graminearum). They have estrogenic activity, cause toxicity in livestock as feed contaminant, and have been used as anabolic or estrogen substitutes.. zearalenone : A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.	3.38	7	0	macrolide; resorcinols	fungal metabolite; mycoestrogen
3-acetyldeoxynivalenol 3-acetyldeoxynivalenol : A trichothecene mycotoxin that is deoxynivalenol acetylated on the oxygen at C-3. A skin and eye irritant, along with its 15-acetyl regioisomer and its parent deoxynivalenol it is considered among the most commonly and widely distributed cereal contaminants.	2.8	3	0	trichothecene	epitope; mycotoxin
zearalenol zearalenol: RN given refers to (3S-(3R,7S,11E))-isomer	2.38	2	0
15-acetyldeoxynivalenol 15-acetyldeoxynivalenol : A trichothecene mycotoxin that is deoxynivalenol acetylated on the oxygen at C-15. A skin and eye irritant, along with its 3-acetyl regioisomer and its parent deoxynivalenol it is considered among the most commonly and widely distributed cereal contaminants.	4.11	4	0	trichothecene	epitope; mycotoxin
deoxynivalenol-3-glucoside deoxynivalenol-3-glucoside: a major conjugate of deoxynivalenol in beer and some brewing intermediates	7.08	1	0	trichothecene
t-2 toxin T-2 Toxin: A potent mycotoxin produced in feedstuffs by several species of the genus FUSARIUM. It elicits a severe inflammatory reaction in animals and has teratogenic effects.. T-2 toxin : A trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals.	2.93	4	0
ht-2 toxin HT-2 toxin : A trichothecene mycotoxin that is T-2 toxin in which the acetyloxy group at position 4S has been hydrolysed to the corresponding hydroxy group. It is the major metabolite of T-2 toxin.	2.41	2	0
fusarenon-x fusarenon-X: mycotoxin isolated from Fusarium nivale; belongs to 12,13-epoxytrichothecene group; structure	2.41	2	0

Condition	Indicated	Relationship Strength	Studies	Trials
Disease Resistance The capacity of an organism to defend itself against pathological processes or the agents of those processes. This most often involves innate immunity whereby the organism responds to pathogens in a generic way. The term disease resistance is used most frequently when referring to plants.	0	2.21	1	0
Autism Spectrum Disorder Wide continuum of associated cognitive and neurobehavioral disorders, including, but not limited to, three core-defining features: impairments in socialization, impairments in verbal and nonverbal communication, and restricted and repetitive patterns of behaviors. (from DSM-V)	0	2.13	1	0
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	0	2.38	2	0
Fungal Diseases [description not available]	0	2.41	2	0
Mycoses Diseases caused by FUNGI.	0	2.41	2	0
Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.	0	1.96	1	0