Page last updated: 2024-08-07 17:11:02
Carbonic anhydrase 9
A carbonic anhydrase 9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16790]
Synonyms
EC 4.2.1.1;
Carbonate dehydratase IX;
Carbonic anhydrase IX;
CA-IX;
CAIX;
Membrane antigen MN;
P54/58N;
Renal cell carcinoma-associated antigen G250;
RCC-associated antigen G250;
pMW1
Research
Bioassay Publications (406)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 2 (0.49) | 18.7374 |
| 1990's | 2 (0.49) | 18.2507 |
| 2000's | 98 (24.14) | 29.6817 |
| 2010's | 234 (57.64) | 24.3611 |
| 2020's | 70 (17.24) | 2.80 |
Compounds (264)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| protocatechuic acid | Homo sapiens (human) | Ki | 4.4500 | 1 | 1 |
| 4-hydroxybenzoic acid | Homo sapiens (human) | Ki | 258.8956 | 3 | 16 |
| hydrobromic acid | Homo sapiens (human) | Ki | 16,000.0000 | 1 | 1 |
| cadaverine | Homo sapiens (human) | Ki | 0.3800 | 1 | 1 |
| catechol | Homo sapiens (human) | Ki | 396.4067 | 4 | 15 |
| hydrochloric acid | Homo sapiens (human) | Ki | 33,000.0000 | 1 | 1 |
| coumarin | Homo sapiens (human) | Ki | 245.4667 | 9 | 9 |
| salicylic acid | Homo sapiens (human) | Ki | 160.9133 | 3 | 15 |
| gallic acid | Homo sapiens (human) | Ki | 6.9900 | 1 | 1 |
| hydrogen sulfide | Homo sapiens (human) | Ki | 7.0000 | 1 | 1 |
| 4-aminophenol | Homo sapiens (human) | Ki | 515.7929 | 2 | 14 |
| cyanic acid | Homo sapiens (human) | Ki | 40.0000 | 1 | 1 |
| carbonic acid | Homo sapiens (human) | Ki | 6,504.3000 | 2 | 2 |
| hydrogen cyanide | Homo sapiens (human) | Ki | 4.0000 | 1 | 1 |
| thiocyanic acid | Homo sapiens (human) | Ki | 130.0000 | 1 | 1 |
| hydroquinone | Homo sapiens (human) | Ki | 118.7136 | 2 | 14 |
| nitric acid | Homo sapiens (human) | Ki | 46,000.0000 | 2 | 2 |
| phenol | Homo sapiens (human) | Ki | 125.1900 | 9 | 20 |
| spermidine | Homo sapiens (human) | Ki | 1.3700 | 1 | 1 |
| spermine | Homo sapiens (human) | Ki | 13.3000 | 2 | 2 |
| sulfuric acid | Homo sapiens (human) | Ki | 154,000.0000 | 1 | 1 |
| catechin | Homo sapiens (human) | Ki | 5.0300 | 1 | 1 |
| beta-resorcylic acid | Homo sapiens (human) | Ki | 68.0000 | 1 | 1 |
| acetaminophen | Homo sapiens (human) | Ki | 146.9214 | 3 | 14 |
| acetazolamide | Homo sapiens (human) | IC50 | 0.4640 | 71 | 71 |
| acetazolamide | Homo sapiens (human) | Ki | 1.7061 | 324 | 393 |
| bumetanide | Homo sapiens (human) | Ki | 18.3242 | 1 | 12 |
| celecoxib | Homo sapiens (human) | IC50 | 0.0160 | 3 | 3 |
| celecoxib | Homo sapiens (human) | Ki | 1.0222 | 14 | 16 |
| chlorambucil | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
| chlorthalidone | Homo sapiens (human) | Ki | 29.5376 | 3 | 18 |
| coumaphos | Homo sapiens (human) | Ki | 6.4100 | 1 | 1 |
| diclofenac | Homo sapiens (human) | IC50 | 100.0000 | 2 | 2 |
| dichlorphenamide | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| dichlorphenamide | Homo sapiens (human) | Ki | 10.4897 | 56 | 93 |
| ethoxzolamide | Homo sapiens (human) | IC50 | 0.0006 | 2 | 2 |
| ethoxzolamide | Homo sapiens (human) | Ki | 2.6899 | 61 | 88 |
| foscarnet | Homo sapiens (human) | Ki | 2,210.0000 | 1 | 1 |
| furosemide | Homo sapiens (human) | Ki | 56.2441 | 3 | 18 |
| 2,5-dihydroxybenzoic acid | Homo sapiens (human) | Ki | 6.6000 | 1 | 1 |
| hydrochlorothiazide | Homo sapiens (human) | Ki | 18.6042 | 1 | 12 |
| hydroflumethiazide | Homo sapiens (human) | Ki | 20.3203 | 1 | 12 |
| hydroxyurea | Homo sapiens (human) | Ki | 23.0000 | 1 | 1 |
| indapamide | Homo sapiens (human) | Ki | 3,040.4713 | 3 | 18 |
| mafenide | Homo sapiens (human) | Ki | 8.4462 | 12 | 13 |
| methazolamide | Homo sapiens (human) | IC50 | 0.0158 | 3 | 3 |
| methazolamide | Homo sapiens (human) | Ki | 2.6970 | 59 | 88 |
| metolazone | Homo sapiens (human) | Ki | 22.0639 | 1 | 12 |
| fenamic acid | Homo sapiens (human) | Ki | 0.0500 | 1 | 1 |
| potassium chloride | Homo sapiens (human) | Ki | 33,000.0000 | 1 | 1 |
| potassium iodide | Homo sapiens (human) | Ki | 7,000.0000 | 1 | 1 |
| probenecid | Homo sapiens (human) | Ki | 0.3600 | 3 | 3 |
| resorcinol | Homo sapiens (human) | Ki | 282.6929 | 2 | 14 |
| resveratrol | Homo sapiens (human) | Ki | 9.5300 | 1 | 1 |
| saccharin | Homo sapiens (human) | Ki | 0.1024 | 10 | 10 |
| imatinib | Homo sapiens (human) | Ki | 0.0757 | 1 | 1 |
| sulfanilamide | Homo sapiens (human) | IC50 | 4.1960 | 3 | 3 |
| sulfanilamide | Homo sapiens (human) | Ki | 11.8309 | 25 | 29 |
| sulpiride | Homo sapiens (human) | Ki | 0.0409 | 6 | 7 |
| sulthiame | Homo sapiens (human) | Ki | 35.2526 | 3 | 18 |
| temozolomide | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
| trichlormethiazide | Homo sapiens (human) | Ki | 43.7561 | 2 | 26 |
| trientine | Homo sapiens (human) | Ki | 39.0000 | 1 | 1 |
| wb 4101 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| zonisamide | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| zonisamide | Homo sapiens (human) | Ki | 83.0922 | 12 | 27 |
| sulfamic acid | Homo sapiens (human) | Ki | 50.6000 | 2 | 2 |
| sucrose | Homo sapiens (human) | Ki | 20.0000 | 1 | 1 |
| carbostyril | Homo sapiens (human) | Ki | 0.0820 | 3 | 3 |
| sodium citrate, anhydrous | Homo sapiens (human) | Ki | 4,930.0000 | 1 | 1 |
| 4-toluenesulfonamide | Homo sapiens (human) | Ki | 2.6230 | 3 | 4 |
| quinethazone | Homo sapiens (human) | Ki | 18.1300 | 1 | 2 |
| veratrole | Homo sapiens (human) | Ki | 8.6300 | 1 | 1 |
| veratric acid | Homo sapiens (human) | Ki | 8.2500 | 1 | 1 |
| benzenearsonic acid | Homo sapiens (human) | Ki | 55.0000 | 1 | 1 |
| benzenesulfonamide | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| 3-hydroxybenzoic acid | Homo sapiens (human) | Ki | 4.5300 | 1 | 1 |
| alpha-resorcylic acid | Homo sapiens (human) | Ki | 4.4100 | 1 | 1 |
| methylparaben | Homo sapiens (human) | Ki | 5.5000 | 1 | 1 |
| gamma-valerolactone | Homo sapiens (human) | Ki | 0.9200 | 1 | 1 |
| diethylenetriamine | Homo sapiens (human) | Ki | 10.6000 | 1 | 1 |
| phenformin | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
| ethyl-p-hydroxybenzoate | Homo sapiens (human) | Ki | 8.2000 | 1 | 1 |
| sulfacetamide | Homo sapiens (human) | Ki | 0.1350 | 1 | 1 |
| malic acid, disodium salt | Homo sapiens (human) | Ki | 7,420.0000 | 1 | 1 |
| carzenide | Homo sapiens (human) | IC50 | 24.0000 | 2 | 2 |
| carzenide | Homo sapiens (human) | Ki | 0.9106 | 8 | 11 |
| 1,4-dimethoxybenzene | Homo sapiens (human) | Ki | 4.1500 | 1 | 1 |
| gamma-resorcylic acid | Homo sapiens (human) | Ki | 5.9000 | 1 | 1 |
| phthalimidine | Homo sapiens (human) | Ki | 0.1740 | 1 | 1 |
| ninhydrin | Homo sapiens (human) | Ki | 2.3700 | 1 | 1 |
| benzohydroxamic acid | Homo sapiens (human) | Ki | 45.9000 | 1 | 1 |
| butenolide | Homo sapiens (human) | Ki | 4.4200 | 1 | 1 |
| flavone | Homo sapiens (human) | Ki | 4.1750 | 2 | 2 |
| syringic acid | Homo sapiens (human) | Ki | 8.2000 | 1 | 1 |
| herniarin | Homo sapiens (human) | Ki | 9.8000 | 1 | 1 |
| coumarin-3-carboxylic acid | Homo sapiens (human) | Ki | 6.5000 | 1 | 1 |
| delta-valerolactone | Homo sapiens (human) | Ki | 3.6600 | 1 | 1 |
| 3-hydroxyflavone | Homo sapiens (human) | Ki | 5.5850 | 2 | 2 |
| 3-aminophenol | Homo sapiens (human) | Ki | 4.9000 | 1 | 1 |
| ferrocin c | Homo sapiens (human) | Ki | 0.0446 | 1 | 1 |
| 4-cyanophenol | Homo sapiens (human) | Ki | 206.4863 | 2 | 14 |
| methylphosphonic acid | Homo sapiens (human) | Ki | 1,260.0000 | 1 | 1 |
| hydrofluoric acid | Homo sapiens (human) | Ki | 48,000.0000 | 1 | 1 |
| n-(1-naphthyl)ethylenediamine | Homo sapiens (human) | Ki | 0.5100 | 1 | 1 |
| 2,6-dimethoxybenzoic acid | Homo sapiens (human) | Ki | 9.0700 | 1 | 1 |
| phenylphosphonic acid | Homo sapiens (human) | Ki | 2,210.0000 | 1 | 1 |
| methylene diphosphonate | Homo sapiens (human) | IC50 | 860.0000 | 1 | 1 |
| methylene diphosphonate | Homo sapiens (human) | Ki | 860.0000 | 1 | 1 |
| 1,6-diaminohexane | Homo sapiens (human) | Ki | 0.4100 | 1 | 1 |
| benzolamide | Homo sapiens (human) | Ki | 9.3728 | 7 | 15 |
| chloric acid | Homo sapiens (human) | Ki | 147,000.0000 | 1 | 1 |
| n-phthalylglycine | Homo sapiens (human) | Ki | 0.2230 | 1 | 1 |
| benzeneseleninic acid | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| phosphoric acid, trisodium salt | Homo sapiens (human) | Ki | 560.0000 | 1 | 1 |
| perchloric acid | Homo sapiens (human) | Ki | 11,600.0000 | 1 | 1 |
| iodic acid | Homo sapiens (human) | Ki | 49,700.0000 | 1 | 1 |
| potassium nitrate | Homo sapiens (human) | Ki | 46,000.0000 | 1 | 1 |
| bromic acid | Homo sapiens (human) | Ki | 274,000.0000 | 1 | 1 |
| hydrazoic acid | Homo sapiens (human) | Ki | 5.0000 | 1 | 1 |
| hydroiodic acid | Homo sapiens (human) | Ki | 7,000.0000 | 1 | 1 |
| salen | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| sodium azide | Homo sapiens (human) | Ki | 5.0000 | 1 | 1 |
| 7-ethoxycoumarin | Homo sapiens (human) | Ki | 9.6000 | 1 | 1 |
| acetosulfame | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| dobutamine | Homo sapiens (human) | Ki | 9.8200 | 1 | 1 |
| 2-aminosulfonyl-benzoic acid methyl ester | Homo sapiens (human) | Ki | 9.3950 | 2 | 4 |
| foscarnet sodium | Homo sapiens (human) | Ki | 2,210.0000 | 2 | 2 |
| succinylsulfanilamide | Homo sapiens (human) | Ki | 0.0128 | 1 | 1 |
| 2,4(1h,3h)-quinazolinedione | Homo sapiens (human) | Ki | 13.7000 | 1 | 1 |
| calanolide b | Homo sapiens (human) | Ki | 0.8300 | 1 | 1 |
| metaperiodate | Homo sapiens (human) | Ki | 30,300.0000 | 1 | 1 |
| xanthyletine | Homo sapiens (human) | Ki | 7.5100 | 1 | 1 |
| xanthoxyletin | Homo sapiens (human) | Ki | 0.7400 | 1 | 1 |
| 4-chlorobenzenesulfonamide | Homo sapiens (human) | Ki | 0.0003 | 1 | 1 |
| benzeneboronic acid | Homo sapiens (human) | Ki | 85.0000 | 2 | 2 |
| 4-amino-6-chloro-1,3-benzenedisulfonamide | Homo sapiens (human) | Ki | 5.0700 | 7 | 8 |
| 1,2,4-trimethoxybenzene | Homo sapiens (human) | Ki | 4.0600 | 1 | 1 |
| 2-pyrone | Homo sapiens (human) | Ki | 1.6000 | 1 | 1 |
| disulphane | Homo sapiens (human) | Ki | 0.0340 | 5 | 5 |
| zoledronic acid | Homo sapiens (human) | IC50 | 5.3230 | 2 | 2 |
| plasmenylserine | Homo sapiens (human) | Ki | 920.0000 | 1 | 1 |
| brinzolamide | Homo sapiens (human) | Ki | 0.0346 | 27 | 33 |
| 2,4-disulfamyl-5-trifluoromethylaniline | Homo sapiens (human) | Ki | 3.2501 | 7 | 8 |
| isoscopoletin | Homo sapiens (human) | Ki | 7.3700 | 1 | 1 |
| n-4-tosylglycine | Homo sapiens (human) | IC50 | 0.2170 | 1 | 1 |
| trichlorosucrose | Homo sapiens (human) | Ki | 2.2000 | 1 | 1 |
| methanesulfonamide | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| 2-aminobenzenesulfonamide | Homo sapiens (human) | Ki | 4.6280 | 9 | 12 |
| methyl gentisate | Homo sapiens (human) | Ki | 0.8400 | 1 | 1 |
| ethyl protocatechuate | Homo sapiens (human) | Ki | 0.7800 | 1 | 1 |
| 3-acetylcoumarin | Homo sapiens (human) | Ki | 0.1518 | 1 | 1 |
| 3,7-diazanonane-1,9-diamine | Homo sapiens (human) | Ki | 48.0000 | 1 | 1 |
| sulfamide | Homo sapiens (human) | Ki | 38.4000 | 3 | 3 |
| 5-amino-1,3,4-thiadiazole-2-sulfonamide | Homo sapiens (human) | Ki | 0.6199 | 13 | 17 |
| methylumbelliferyl-beta-d-xyloside | Homo sapiens (human) | Ki | 0.3500 | 1 | 1 |
| 7-amino-4-methylcoumarin | Homo sapiens (human) | Ki | 7.6400 | 1 | 1 |
| 4-methylumbelliferyl-galactopyranoside | Homo sapiens (human) | Ki | 0.0930 | 1 | 1 |
| 4-methyl-N-(phenylmethyl)benzenesulfonamide | Homo sapiens (human) | IC50 | 0.0760 | 1 | 1 |
| hepsulfam | Homo sapiens (human) | Ki | 0.0101 | 1 | 1 |
| taurineamide | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| valdecoxib | Homo sapiens (human) | IC50 | 0.0270 | 2 | 2 |
| valdecoxib | Homo sapiens (human) | Ki | 2.7827 | 9 | 10 |
| estrone-3-o-sulfamate | Homo sapiens (human) | Ki | 0.0300 | 4 | 4 |
| 1-naphthylacetylspermine | Homo sapiens (human) | Ki | 0.1200 | 1 | 1 |
| 4-guanidinobenzoate | Homo sapiens (human) | Ki | 2.5600 | 1 | 1 |
| naphthalenesulfonamide | Homo sapiens (human) | Ki | 0.0300 | 2 | 2 |
| chlorzolamide | Homo sapiens (human) | Ki | 0.0340 | 4 | 7 |
| 4-(2-aminoethyl)benzenesulfonamide | Homo sapiens (human) | Ki | 2.2495 | 15 | 16 |
| sorafenib | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| n-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide | Homo sapiens (human) | Ki | 0.0248 | 39 | 52 |
| lacosamide | Homo sapiens (human) | Ki | 0.3530 | 1 | 1 |
| 3-hydroxy-quinazoline-2,4-dione | Homo sapiens (human) | Ki | 0.4800 | 1 | 1 |
| salophen | Homo sapiens (human) | Ki | 2.4500 | 1 | 1 |
| potassium bromide | Homo sapiens (human) | Ki | 16,000.0000 | 1 | 1 |
| n,n'-bis(salicylidene)-1,6-hexanediamine | Homo sapiens (human) | Ki | 4.3500 | 1 | 1 |
| methyl 3,4-dihydroxybenzoate | Homo sapiens (human) | Ki | 0.7900 | 1 | 1 |
| u-104 | Homo sapiens (human) | Ki | 0.0431 | 23 | 23 |
| diba-1 | Homo sapiens (human) | Ki | 2.2568 | 3 | 5 |
| bortezomib | Homo sapiens (human) | Ki | 3.3800 | 1 | 1 |
| 1-hydroxy-2,1-benzoxaborole | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
| scopolin | Homo sapiens (human) | Ki | 8.7200 | 1 | 1 |
| resveratrol | Homo sapiens (human) | Ki | 0.8100 | 1 | 1 |
| rwj 37947 | Homo sapiens (human) | Ki | 0.0360 | 1 | 1 |
| ferulic acid | Homo sapiens (human) | IC50 | 9.3900 | 1 | 1 |
| ferulic acid | Homo sapiens (human) | Ki | 9.8700 | 1 | 1 |
| bay 57-1293 | Homo sapiens (human) | Ki | 0.0810 | 1 | 1 |
| sodium thiocyanate | Homo sapiens (human) | Ki | 130.0000 | 1 | 1 |
| sodium bicarbonate | Homo sapiens (human) | Ki | 13,000.0000 | 2 | 2 |
| sodium acetate, anhydrous | Homo sapiens (human) | Ki | 150,000.0000 | 1 | 1 |
| sodium benzoate | Homo sapiens (human) | Ki | 150,000.0000 | 1 | 1 |
| potassium fluoride | Homo sapiens (human) | Ki | 48,000.0000 | 1 | 1 |
| ditiocarb sodium | Homo sapiens (human) | Ki | 1.4130 | 1 | 1 |
| hydroxyphenethylferulate | Homo sapiens (human) | Ki | 0.8100 | 1 | 1 |
| 2-hydroxycinnamic acid | Homo sapiens (human) | Ki | 700.0000 | 3 | 3 |
| trans-4-coumaric acid | Homo sapiens (human) | Ki | 5.3300 | 1 | 1 |
| (R)-(+)-sulpiride | Homo sapiens (human) | Ki | 0.0310 | 1 | 1 |
| s 1033 | Homo sapiens (human) | Ki | 0.0419 | 1 | 1 |
| ethyl coumarate | Homo sapiens (human) | Ki | 0.6100 | 1 | 1 |
| caffeic acid | Homo sapiens (human) | Ki | 7.8700 | 1 | 1 |
| 4-methoxycinnamic acid | Homo sapiens (human) | IC50 | 850.0000 | 1 | 1 |
| 1-(4-chlorophenyl)-3-(4-sulfamoylphenyl)urea | Homo sapiens (human) | Ki | 0.0580 | 1 | 1 |
| ethyl 2,4-dihydroxybenzoate | Homo sapiens (human) | Ki | 0.8200 | 1 | 1 |
| 7-methoxy-2-oxo-1-benzopyran-3-carboxylic acid ethyl ester | Homo sapiens (human) | Ki | 9.4000 | 1 | 1 |
| 7-acetoxycoumarin | Homo sapiens (human) | Ki | 0.0402 | 1 | 1 |
| formic acid, sodium salt | Homo sapiens (human) | Ki | 1,220.0000 | 2 | 2 |
| 2-amino-5-mercapto-1,3,4-thiadiazole | Homo sapiens (human) | Ki | 9.3000 | 1 | 1 |
| N1-[4-(aminosulfonyl)phenyl]-2,2-dimethylpropanamide | Homo sapiens (human) | Ki | 0.1360 | 1 | 1 |
| 4-methylumbelliferyl glucoside | Homo sapiens (human) | Ki | 0.3700 | 1 | 1 |
| 6,7,8-trimethoxycoumarin | Homo sapiens (human) | Ki | 6.5800 | 1 | 1 |
| 2,6-dibromosulfanilamide | Homo sapiens (human) | Ki | 2.0068 | 2 | 5 |
| 4-azidosulfanilamide | Homo sapiens (human) | Ki | 0.7278 | 4 | 6 |
| d 609 | Homo sapiens (human) | Ki | 0.6430 | 1 | 1 |
| sc 560 | Homo sapiens (human) | IC50 | 100.0000 | 2 | 2 |
| sitagliptin | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| sodium hexafluorophosphate | Homo sapiens (human) | Ki | 8,100.0000 | 1 | 1 |
| fraxin | Homo sapiens (human) | Ki | 0.3700 | 1 | 1 |
| fraxetin | Homo sapiens (human) | Ki | 0.6100 | 1 | 1 |
| quercetin | Homo sapiens (human) | Ki | 7.0000 | 1 | 1 |
| scopoletin | Homo sapiens (human) | Ki | 0.9600 | 1 | 1 |
| hymecromone | Homo sapiens (human) | Ki | 42.0220 | 2 | 5 |
| esculetin | Homo sapiens (human) | Ki | 0.0364 | 1 | 1 |
| 7-hydroxycoumarin | Homo sapiens (human) | Ki | 0.3662 | 4 | 4 |
| chrysin | Homo sapiens (human) | Ki | 2.6800 | 2 | 2 |
| ellagic acid | Homo sapiens (human) | Ki | 44.5850 | 2 | 2 |
| 7-hydroxyflavone | Homo sapiens (human) | Ki | 4.8850 | 2 | 2 |
| dorzolamide | Homo sapiens (human) | IC50 | 0.0520 | 1 | 1 |
| dorzolamide | Homo sapiens (human) | Ki | 19.3305 | 35 | 56 |
| topiramate | Homo sapiens (human) | Ki | 16.8509 | 29 | 51 |
| irosustat | Homo sapiens (human) | Ki | 54.4262 | 2 | 13 |
| methyl-p-coumarate | Homo sapiens (human) | Ki | 0.8500 | 1 | 1 |
| 5,7-dihydroxy-4-methylcoumarin | Homo sapiens (human) | Ki | 53.7475 | 1 | 4 |
| 7,8-dihydroxy-4-methylcoumarin | Homo sapiens (human) | Ki | 53.8925 | 1 | 4 |
| 3-cyano-7-hydroxycoumarin | Homo sapiens (human) | Ki | 48.2209 | 1 | 11 |
| famotidine | Homo sapiens (human) | Ki | 0.1263 | 1 | 1 |
| geiparvarin | Homo sapiens (human) | Ki | 0.6000 | 1 | 1 |
| benzeneselenol | Homo sapiens (human) | Ki | 0.1800 | 1 | 1 |
| 6-hydroxybenzothiazide-2-sulfonamide | Homo sapiens (human) | Ki | 0.0339 | 6 | 7 |
| 2-methoxyestradiol-3,17-o,o-bis(sulfamate) | Homo sapiens (human) | Ki | 0.0700 | 1 | 1 |
| pazopanib | Homo sapiens (human) | Ki | 0.0091 | 1 | 1 |
| acesulfame potassium | Homo sapiens (human) | Ki | 2.4067 | 3 | 3 |
| 2-ethylestradiol sulfamate | Homo sapiens (human) | Ki | 0.2500 | 1 | 1 |
| trans-avicennol | Homo sapiens (human) | Ki | 0.7800 | 1 | 1 |
| cryolite | Homo sapiens (human) | Ki | 18,500.0000 | 1 | 1 |
| sodium lactate | Homo sapiens (human) | Ki | 150,000.0000 | 1 | 1 |
| ve 821 | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
| dihydroxyfumarate | Homo sapiens (human) | Ki | 6.7000 | 1 | 1 |
| 4-hydroxycoumarin | Homo sapiens (human) | Ki | 0.4100 | 1 | 1 |
| vx-970 | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
| 4-hydroxyquinazoline | Homo sapiens (human) | Ki | 15.7000 | 1 | 1 |
| tirapazamine | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
Drugs with Activation Measurements
Drugs with Other Measurements
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Interaction of carbonic anhydrase isozymes I, II, and IX with some pyridine and phenol hydrazinecarbothioamide derivatives.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins.Journal of medicinal chemistry, , Jan-14, Volume: 59, Issue:1, 2016
Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases.Journal of medicinal chemistry, , Jan-10, Volume: 56, Issue:1, 2013
Natural product coumarins that inhibit human carbonic anhydrases.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 22, Issue:6, 2012
5- and 6-membered (thio)lactones are prodrug type carbonic anhydrase inhibitors.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 22, Issue:1, 2012
Novel coumarins and 2-thioxo-coumarins as inhibitors of the tumor-associated carbonic anhydrases IX and XII.Bioorganic & medicinal chemistry, , Apr-01, Volume: 20, Issue:7, 2012
Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.Journal of medicinal chemistry, , Dec-22, Volume: 54, Issue:24, 2011
Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.Journal of medicinal chemistry, , Jan-14, Volume: 53, Issue:1, 2010
7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 20, Issue:24, 2010
Interaction of carbonic anhydrase isozymes I, II, and IX with some pyridine and phenol hydrazinecarbothioamide derivatives.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.Bioorganic & medicinal chemistry, , Aug-15, Volume: 17, Issue:16, 2009
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Interaction of carbonic anhydrase isozymes I, II, and IX with some pyridine and phenol hydrazinecarbothioamide derivatives.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Salen and tetrahydrosalen derivatives act as effective inhibitors of the tumor-associated carbonic anhydrase XII--a new scaffold for designing isoform-selective inhibitors.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 23, Issue:24, 2013
Synthesis of C-cinnamoyl glycosides and their inhibitory activity against mammalian carbonic anhydrases.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 23, Issue:3, 2013
Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site.Bioorganic & medicinal chemistry, , Feb-15, Volume: 19, Issue:4, 2011
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site.Bioorganic & medicinal chemistry, , Feb-15, Volume: 19, Issue:4, 2011
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Interaction of carbonic anhydrase isozymes I, II, and IX with some pyridine and phenol hydrazinecarbothioamide derivatives.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Discovery of a Potent and Highly Selective Dipeptidyl Peptidase IV and Carbonic Anhydrase Inhibitor as "Antidiabesity" Agents Based on Repurposing and Morphing of WB-4101.Journal of medicinal chemistry, , 10-27, Volume: 65, Issue:20, 2022
[no title available]European journal of medicinal chemistry, , Jan-15, Volume: 228, 2022
Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases.European journal of medicinal chemistry, , Apr-15, Volume: 234, 2022
Design, synthesis and human carbonic anhydrase I, II, IX and XII inhibitory properties of 1,3-thiazole sulfonamides.Bioorganic & medicinal chemistry letters, , 03-01, Volume: 59, 2022
Synthesis of a new series of quinoline/pyridine indole-3-sulfonamide hybrids as selective carbonic anhydrase IX inhibitors.Bioorganic & medicinal chemistry letters, , 08-15, Volume: 70, 2022
Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail/dual-tail approaches as novel carbonic anhydrase inhibitors.European journal of medicinal chemistry, , Aug-05, Volume: 238, 2022
One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes.Journal of medicinal chemistry, , 01-13, Volume: 65, Issue:1, 2022
2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity.European journal of medicinal chemistry, , Jan-15, Volume: 228, 2022
[no title available]Journal of medicinal chemistry, , 11-10, Volume: 65, Issue:21, 2022
Discovery of new carbonic anhydrase IX inhibitors as anticancer agents by toning the hydrophobic and hydrophilic rims of the active site to encounter the dual-tail approach.European journal of medicinal chemistry, , Mar-15, Volume: 232, 2022
Sultam based Carbonic Anhydrase VII inhibitors for the management of neuropathic pain.European journal of medicinal chemistry, , Jan-05, Volume: 227, 2022
Chlorinated benzothiadiazines inhibit angiogenesis through suppression of VEGFR2 phosphorylation.Bioorganic & medicinal chemistry, , 08-01, Volume: 67, 2022
[no title available]Journal of medicinal chemistry, , 10-13, Volume: 65, Issue:19, 2022
Synthesis, biological evaluation, and in silico studies of potential activators of apoptosis and carbonic anhydrase inhibitors on isatin-5-sulfonamide scaffold.European journal of medicinal chemistry, , Jan-15, Volume: 228, 2022
Natural inspired ligustrazine-based SLC-0111 analogues as novel carbonic anhydrase inhibitors.European journal of medicinal chemistry, , Jan-15, Volume: 228, 2022
Mechanisms of the Antiproliferative and Antitumor Activity of Novel Telomerase-Carbonic Anhydrase Dual-Hybrid Inhibitors.Journal of medicinal chemistry, , 08-12, Volume: 64, Issue:15, 2021
Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors.European journal of medicinal chemistry, , Jan-01, Volume: 209, 2021
Discovery of novel aminosaccharide-based sulfonamide derivatives as potential carbonic anhydrase II inhibitors.Bioorganic & medicinal chemistry letters, , 12-01, Volume: 53, 2021
Novel carbohydrate-based sulfonamide derivatives as selective carbonic anhydrase II inhibitors: Synthesis, biological and molecular docking analysis.Bioorganic & medicinal chemistry letters, , 11-01, Volume: 51, 2021
Novel benzenesulfonamides aryl and arylsulfone conjugates adopting tail/dual tail approaches: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies.European journal of medicinal chemistry, , Oct-05, Volume: 221, 2021
Investigation of 3-sulfamoyl coumarins against cancer-related IX and XII isoforms of human carbonic anhydrase as well as cancer cells leads to the discovery of 2-oxo-2H-benzo[h]chromene-3-sulfonamide - A new caspase-activating proapoptotic agent.European journal of medicinal chemistry, , Oct-15, Volume: 222, 2021
Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors.European journal of medicinal chemistry, , Apr-15, Volume: 216, 2021
Design, synthesis and biochemical evaluation of novel carbonic anhydrase inhibitors triggered by structural knowledge on hCA VII.Bioorganic & medicinal chemistry, , 08-15, Volume: 44, 2021
Novel 3-substituted coumarins as selective human carbonic anhydrase IX and XII inhibitors: Synthesis, biological and molecular dynamics analysis.European journal of medicinal chemistry, , Jan-01, Volume: 209, 2021
3-Functionalised benzenesulphonamide based 1,3,4-oxadiazoles as selective carbonic anhydrase XIII inhibitors: Design, synthesis and biological evaluation.Bioorganic & medicinal chemistry letters, , 04-01, Volume: 37, 2021
Natural inspired piperine-based sulfonamides and carboxylic acids as carbonic anhydrase inhibitors: Design, synthesis and biological evaluation.European journal of medicinal chemistry, , Dec-05, Volume: 225, 2021
Chalcogenides-incorporating carbonic anhydrase inhibitors concomitantly reverted oxaliplatin-induced neuropathy and enhanced antiproliferative action.European journal of medicinal chemistry, , Dec-05, Volume: 225, 2021
Synthesis and biological evaluation of novel 4,7-disubstituted coumarins as selective tumor-associated carbonic anhydrase IX and XII inhibitors.Bioorganic & medicinal chemistry letters, , 05-01, Volume: 39, 2021
Ninhydrins inhibit carbonic anhydrases directly binding to the metal ion.European journal of medicinal chemistry, , Jan-01, Volume: 209, 2021
Handling drug-target selectivity: A study on ureido containing Carbonic Anhydrase inhibitors.European journal of medicinal chemistry, , Feb-15, Volume: 212, 2021
Design, synthesis and biological evaluation of sulfamoylphenyl-quinazoline derivatives as potential EGFR/CAIX dual inhibitors.European journal of medicinal chemistry, , Apr-15, Volume: 216, 2021
Tellurides bearing benzensulfonamide as carbonic anhydrase inhibitors with potent antitumor activity.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 45, 2021
Insertion of metal carbenes into the anilinic N-H bond of unprotected aminobenzenesulfonamides delivers low nanomolar inhibitors of human carbonic anhydrase IX and XII isoforms.European journal of medicinal chemistry, , Jun-05, Volume: 218, 2021
Developments of small molecules as inhibitors for carbonic anhydrase isoforms.Bioorganic & medicinal chemistry, , 06-01, Volume: 39, 2021
Comprehensive study on potent and selective carbonic anhydrase inhibitors: Synthesis, bioactivities and molecular modelling studies of 4-(3-(2-arylidenehydrazine-1-carbonyl)-5-(thiophen-2-yl)-1H-pyrazole-1-yl) benzenesulfonamides.European journal of medicinal chemistry, , May-05, Volume: 217, 2021
Identification of N-phenyl-2-(phenylsulfonyl)acetamides/propanamides as new SLC-0111 analogues: Synthesis and evaluation of the carbonic anhydrase inhibitory activities.European journal of medicinal chemistry, , Jun-05, Volume: 218, 2021
Novel triazole-sulfonamide bearing pyrimidine moieties with carbonic anhydrase inhibitory action: Design, synthesis, computational and enzyme inhibition studies.Bioorganic & medicinal chemistry letters, , 09-15, Volume: 48, 2021
Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer.Journal of medicinal chemistry, , 02-11, Volume: 64, Issue:3, 2021
Inhibition studies on carbonic anhydrase isoforms I, II, IV and IX with N-arylsubstituted secondary sulfonamides featuring a bicyclic tetrahydroindazole scaffold.European journal of medicinal chemistry, , Aug-05, Volume: 220, 2021
Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective.European journal of medicinal chemistry, , Jan-15, Volume: 210, 2021
Privileged scaffolds in medicinal chemistry: Studies on pyrazolo[1,5-a]pyrimidines on sulfonamide containing Carbonic Anhydrase inhibitors.Bioorganic & medicinal chemistry letters, , 10-01, Volume: 49, 2021
New coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation.Bioorganic & medicinal chemistry, , 08-01, Volume: 28, Issue:15, 2020
Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation.European journal of medicinal chemistry, , Mar-01, Volume: 189, 2020
New thiopyrimidine-benzenesulfonamide conjugates as selective carbonic anhydrase II inhibitors: synthesis, in vitro biological evaluation, and molecular docking studies.Bioorganic & medicinal chemistry, , 03-01, Volume: 28, Issue:5, 2020
Design, synthesis & biological evaluation of ferulic acid-based small molecule inhibitors against tumor-associated carbonic anhydrase IX.Bioorganic & medicinal chemistry, , 05-01, Volume: 28, Issue:9, 2020
New Dihydrothiazole Benzensulfonamides: Looking for Selectivity toward Carbonic Anhydrase Isoforms I, II, IX, and XII.ACS medicinal chemistry letters, , May-14, Volume: 11, Issue:5, 2020
[no title available]ACS medicinal chemistry letters, , May-14, Volume: 11, Issue:5, 2020
Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy.Journal of medicinal chemistry, , 05-28, Volume: 63, Issue:10, 2020
1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors.Journal of medicinal chemistry, , 03-12, Volume: 63, Issue:5, 2020
Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms.European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
3-Methylthiazolo[3,2-a]benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies.European journal of medicinal chemistry, , Dec-01, Volume: 207, 2020
Discovery of first-in-class multi-target adenosine AEuropean journal of medicinal chemistry, , Sep-01, Volume: 201, 2020
Structural Basis of Nanomolar Inhibition of Tumor-Associated Carbonic Anhydrase IX: X-Ray Crystallographic and Inhibition Study of Lipophilic Inhibitors with Acetazolamide Backbone.Journal of medicinal chemistry, , 11-12, Volume: 63, Issue:21, 2020
Glycomimetic Based Approach toward Selective Carbonic Anhydrase Inhibitors.ACS medicinal chemistry letters, , May-14, Volume: 11, Issue:5, 2020
Azidothymidine "Clicked" into 1,2,3-Triazoles: First Report on Carbonic Anhydrase-Telomerase Dual-Hybrid Inhibitors.Journal of medicinal chemistry, , 07-09, Volume: 63, Issue:13, 2020
[no title available]Journal of medicinal chemistry, , 01-09, Volume: 63, Issue:1, 2020
Synthesis, biological and molecular dynamics investigations with a series of triazolopyrimidine/triazole-based benzenesulfonamides as novel carbonic anhydrase inhibitors.European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases.European journal of medicinal chemistry, , Aug-15, Volume: 200, 2020
[no title available]European journal of medicinal chemistry, , Mar-15, Volume: 190, 2020
Tail approach synthesis of novel benzenesulfonamides incorporating 1,3,4-oxadiazole hybrids as potent inhibitor of carbonic anhydrase I, II, IX, and XII isoenzymes.European journal of medicinal chemistry, , May-01, Volume: 193, 2020
Direct and straightforward access to substituted alkyl selenols as novel carbonic anhydrase inhibitors.European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
Benzoxepinones: A new isoform-selective class of tumor associated carbonic anhydrase inhibitors.Bioorganic & medicinal chemistry, , 06-01, Volume: 28, Issue:11, 2020
Discovery of New 1,1'-Biphenyl-4-sulfonamides as Selective Subnanomolar Human Carbonic Anhydrase II Inhibitors.ACS medicinal chemistry letters, , May-14, Volume: 11, Issue:5, 2020
Iodoquinazolinones bearing benzenesulfonamide as human carbonic anhydrase I, II, IX and XII inhibitors: Synthesis, biological evaluation and radiosensitizing activity.European journal of medicinal chemistry, , Aug-15, Volume: 200, 2020
Development of oxathiino[6,5-b]pyridine 2,2-dioxide derivatives as selective inhibitors of tumor-related carbonic anhydrases IX and XII.European journal of medicinal chemistry, , Aug-15, Volume: 200, 2020
Benzofuran-Based Carboxylic Acids as Carbonic Anhydrase Inhibitors and Antiproliferative Agents against Breast Cancer.ACS medicinal chemistry letters, , May-14, Volume: 11, Issue:5, 2020
Bioisosteric Development of Multitarget Nonsteroidal Anti-Inflammatory Drug-Carbonic Anhydrases Inhibitor Hybrids for the Management of Rheumatoid Arthritis.Journal of medicinal chemistry, , 03-12, Volume: 63, Issue:5, 2020
Sulfonamide/sulfamate switch with a series of piperazinylureido derivatives: Synthesis, kinetic and in silico evaluation as carbonic anhydrase isoforms I, II, IV, and IX inhibitors.European journal of medicinal chemistry, , Jan-15, Volume: 186, 2020
Pyrrolo and pyrrolopyrimidine sulfonamides act as cytotoxic agents in hypoxia via inhibition of transmembrane carbonic anhydrases.European journal of medicinal chemistry, , Feb-15, Volume: 188, 2020
Continued exploration and tail approach synthesis of benzenesulfonamides containing triazole and dual triazole moieties as carbonic anhydrase I, II, IV and IX inhibitors.European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Continued exploration of 1,2,4-oxadiazole periphery for carbonic anhydrase-targeting primary arene sulfonamides: Discovery of subnanomolar inhibitors of membrane-bound hCA IX isoform that selectively kill cancer cells in hypoxic environment.European journal of medicinal chemistry, , Feb-15, Volume: 164, 2019
Discovery of new ureido benzenesulfonamides incorporating 1,3,5-triazine moieties as carbonic anhydrase I, II, IX and XII inhibitors.Bioorganic & medicinal chemistry, , 04-15, Volume: 27, Issue:8, 2019
5-Arylisothiazol-3(2H)-one-1,(1)-(di)oxides: A new class of selective tumor-associated carbonic anhydrases (hCA IX and XII) inhibitors.European journal of medicinal chemistry, , Aug-01, Volume: 175, 2019
Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines.European journal of medicinal chemistry, , Apr-15, Volume: 168, 2019
Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells.European journal of medicinal chemistry, , Nov-15, Volume: 182, 2019
Structure-activity relationship with pyrazoline-based aromatic sulfamates as carbonic anhydrase isoforms I, II, IX and XII inhibitors: Synthesis and biological evaluation.European journal of medicinal chemistry, , Nov-15, Volume: 182, 2019
New anthranilic acid-incorporating N-benzenesulfonamidophthalimides as potent inhibitors of carbonic anhydrases I, II, IX, and XII: Synthesis, in vitro testing, and in silico assessment.European journal of medicinal chemistry, , Nov-01, Volume: 181, 2019
Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Carbonic Anhydrase XII Inhibitors Overcome Temozolomide Resistance in Glioblastoma.Journal of medicinal chemistry, , 04-25, Volume: 62, Issue:8, 2019
Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety.European journal of medicinal chemistry, , Feb-01, Volume: 163, 2019
Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents.European journal of medicinal chemistry, , Jan-15, Volume: 162, 2019
Synthesis and exploration of 2-morpholino-4-phenylthiazol-5-yl acrylamide derivatives for their effects against carbonic anhydrase I, II, IX and XII isoforms as a non-sulfonamide class of inhibitors.Bioorganic & medicinal chemistry, , 11-01, Volume: 27, Issue:21, 2019
Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity.European journal of medicinal chemistry, , Nov-01, Volume: 181, 2019
Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis.Journal of medicinal chemistry, , 08-08, Volume: 62, Issue:15, 2019
Synthesis of coumarin-sulfonamide derivatives and determination of their cytotoxicity, carbonic anhydrase inhibitory and molecular docking studies.European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Bis-benzoxaboroles: Design, Synthesis, and Biological Evaluation as Carbonic Anhydrase Inhibitors.ACS medicinal chemistry letters, , Aug-08, Volume: 10, Issue:8, 2019
Application of hydrazino and hydrazido linkers to connect benzenesulfonamides with hydrophilic/phobic tails for targeting the middle region of human carbonic anhydrases active site: Selective inhibitors of hCA IX.European journal of medicinal chemistry, , Oct-01, Volume: 179, 2019
[no title available]ACS medicinal chemistry letters, , Apr-11, Volume: 10, Issue:4, 2019
3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights.European journal of medicinal chemistry, , Dec-15, Volume: 184, 2019
Synthesis, characterization and biological evaluation of tertiary sulfonamide derivatives of pyridyl-indole based heteroaryl chalcone as potential carbonic anhydrase IX inhibitors and anticancer agents.European journal of medicinal chemistry, , Jul-15, Volume: 155, 2018
4-Substituted Benzenesulfonamides Incorporating Bi/Tricyclic Moieties Act as Potent and Isoform-Selective Carbonic Anhydrase II/IX Inhibitors.Journal of medicinal chemistry, , 07-12, Volume: 61, Issue:13, 2018
Discovery of Benzenesulfonamide Derivatives as Carbonic Anhydrase Inhibitors with Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Evaluation.Journal of medicinal chemistry, , 04-12, Volume: 61, Issue:7, 2018
Developing hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery.Bioorganic & medicinal chemistry, , 07-30, Volume: 26, Issue:13, 2018
4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII Showing Hypoxia-Enhanced Antiproliferative Profiles.Journal of medicinal chemistry, , 12-13, Volume: 61, Issue:23, 2018
Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX.Journal of medicinal chemistry, , 07-26, Volume: 61, Issue:14, 2018
Discovery of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Management of Rheumatoid Arthritis.Journal of medicinal chemistry, , 06-14, Volume: 61, Issue:11, 2018
Introduction of Intrinsic Kinetics of Protein-Ligand Interactions and Their Implications for Drug Design.Journal of medicinal chemistry, , 03-22, Volume: 61, Issue:6, 2018
Design and synthesis of novel benzenesulfonamide containing 1,2,3-triazoles as potent human carbonic anhydrase isoforms I, II, IV and IX inhibitors.European journal of medicinal chemistry, , Jul-15, Volume: 155, 2018
Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects.European journal of medicinal chemistry, , Jun-25, Volume: 154, 2018
2-Benzylpiperazine: A new scaffold for potent human carbonic anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents.European journal of medicinal chemistry, , May-10, Volume: 151, 2018
[no title available]European journal of medicinal chemistry, , Jan-01, Volume: 143, 2018
Discovery of potent anti-convulsant carbonic anhydrase inhibitors: Design, synthesis, in vitro and in vivo appraisal.European journal of medicinal chemistry, , Aug-05, Volume: 156, 2018
Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform.European journal of medicinal chemistry, , May-25, Volume: 152, 2018
Targeting Tumor Associated Carbonic Anhydrases IX and XII: Highly Isozyme Selective Coumarin and Psoralen Inhibitors.ACS medicinal chemistry letters, , Jul-12, Volume: 9, Issue:7, 2018
Design, synthesis and biological evaluation of novel pyridine-thiazolidinone derivatives as anticancer agents: Targeting human carbonic anhydrase IX.European journal of medicinal chemistry, , Jan-20, Volume: 144, 2018
Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy.Journal of medicinal chemistry, , 06-28, Volume: 61, Issue:12, 2018
Tuning the Dual Inhibition of Carbonic Anhydrase and Cyclooxygenase by Dihydrothiazole Benzensulfonamides.ACS medicinal chemistry letters, , Oct-11, Volume: 9, Issue:10, 2018
Famotidine, an Antiulcer Agent, Strongly Inhibits ACS medicinal chemistry letters, , Oct-11, Volume: 9, Issue:10, 2018
Discovery of new 2, 5-disubstituted 1,3-selenazoles as selective human carbonic anhydrase IX inhibitors with potent anti-tumor activity.European journal of medicinal chemistry, , Sep-05, Volume: 157, 2018
Novel hydrazido benzenesulfonamides-isatin conjugates: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies.European journal of medicinal chemistry, , Sep-05, Volume: 157, 2018
Synthesis of novel 4-functionalized 1,5-diaryl-1,2,3-triazoles containing benzenesulfonamide moiety as carbonic anhydrase I, II, IV and IX inhibitors.European journal of medicinal chemistry, , Apr-25, Volume: 150, 2018
Heterocoumarins Are Selective Carbonic Anhydrase IX and XII Inhibitors with Cytotoxic Effects against Cancer Cells Lines.ACS medicinal chemistry letters, , Sep-13, Volume: 9, Issue:9, 2018
Benzimidazole design, synthesis, and docking to build selective carbonic anhydrase VA inhibitors.Bioorganic & medicinal chemistry, , 02-01, Volume: 26, Issue:3, 2018
Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII.European journal of medicinal chemistry, , Feb-25, Volume: 146, 2018
Novel benzoyl thioureido benzene sulfonamides as highly potent and selective inhibitors of carbonic anhydrase IX: optimization and bioactive studies.MedChemComm, , Dec-01, Volume: 9, Issue:12, 2018
Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology.ACS medicinal chemistry letters, , May-10, Volume: 9, Issue:5, 2018
Inhibitory effects and structural insights for a novel series of coumarin-based compounds that selectively target human CA IX and CA XII carbonic anhydrases.European journal of medicinal chemistry, , Jan-01, Volume: 143, 2018
3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold To Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII.Journal of medicinal chemistry, , 07-27, Volume: 60, Issue:14, 2017
Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases.ACS medicinal chemistry letters, , Dec-14, Volume: 8, Issue:12, 2017
N-Substituted and ring opened saccharin derivatives selectively inhibit transmembrane, tumor-associated carbonic anhydrases IX and XII.Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
Development of sulfonamides incorporating phenylacrylamido functionalities as carbonic anhydrase isoforms I, II, IX and XII inhibitors.Bioorganic & medicinal chemistry, , 10-15, Volume: 25, Issue:20, 2017
Synthesis and carbonic anhydrase inhibition of polycyclic imides incorporating N-benzenesulfonamide moieties.Bioorganic & medicinal chemistry, , 10-15, Volume: 25, Issue:20, 2017
Synthesis of novel acyl selenoureido benzensulfonamides as carbonic anhydrase I, II, VII and IX inhibitors.Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
Lead Development of Thiazolylsulfonamides with Carbonic Anhydrase Inhibitory Action.Journal of medicinal chemistry, , 04-13, Volume: 60, Issue:7, 2017
Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors.ACS medicinal chemistry letters, , Sep-14, Volume: 8, Issue:9, 2017
Benzenesulfonamide bearing imidazothiadiazole and thiazolotriazole scaffolds as potent tumor associated human carbonic anhydrase IX and XII inhibitors.Bioorganic & medicinal chemistry, , 02-01, Volume: 25, Issue:3, 2017
Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX).Journal of medicinal chemistry, , 11-09, Volume: 60, Issue:21, 2017
Synthesis and carbonic anhydrase inhibition of a series of SLC-0111 analogs.Bioorganic & medicinal chemistry, , 05-01, Volume: 25, Issue:9, 2017
Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity.Bioorganic & medicinal chemistry, , 01-15, Volume: 25, Issue:2, 2017
[no title available]ACS medicinal chemistry letters, , Aug-10, Volume: 8, Issue:8, 2017
Evaluation of selenide, diselenide and selenoheterocycle derivatives as carbonic anhydrase I, II, IV, VII and IX inhibitors.Bioorganic & medicinal chemistry, , 04-15, Volume: 25, Issue:8, 2017
1,3-Oxazole-based selective picomolar inhibitors of cytosolic human carbonic anhydrase II alleviate ocular hypertension in rabbits: Potency is supported by X-ray crystallography of two leads.Bioorganic & medicinal chemistry, , 09-01, Volume: 25, Issue:17, 2017
Synthesis and biological evaluation of cyclic imides incorporating benzenesulfonamide moieties as carbonic anhydrase I, II, IV and IX inhibitors.Bioorganic & medicinal chemistry, , 03-01, Volume: 25, Issue:5, 2017
Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Treatment of Rheumatoid Arthritis.Journal of medicinal chemistry, , 02-09, Volume: 60, Issue:3, 2017
New approach of delivering cytotoxic drugs towards CAIX expressing cells: A concept of dual-target drugs.European journal of medicinal chemistry, , Feb-15, Volume: 127, 2017
Synthesis of new 3-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-benzenesulfonamides with strong inhibition properties against the tumor associated carbonic anhydrases IX and XII.Bioorganic & medicinal chemistry, , 05-15, Volume: 25, Issue:10, 2017
Bortezomib inhibits mammalian carbonic anhydrases.Bioorganic & medicinal chemistry, , 10-01, Volume: 25, Issue:19, 2017
Synthesis of bulky-tailed sulfonamides incorporating pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-1(5H)-yl) moieties and evaluation of their carbonic anhydrases I, II, IV and IX inhibitory effects.Bioorganic & medicinal chemistry, , 04-01, Volume: 25, Issue:7, 2017
Synthesis of Novel Selenides Bearing Benzenesulfonamide Moieties as Carbonic Anhydrase I, II, IV, VII, and IX Inhibitors.ACS medicinal chemistry letters, , Dec-14, Volume: 8, Issue:12, 2017
Synthesis and biological evaluation of novel aromatic and heterocyclic bis-sulfonamide Schiff bases as carbonic anhydrase I, II, VII and IX inhibitors.Bioorganic & medicinal chemistry, , 06-15, Volume: 25, Issue:12, 2017
Novel sulfonamide-containing 2-indolinones that selectively inhibit tumor-associated alpha carbonic anhydrases.Bioorganic & medicinal chemistry, , 07-15, Volume: 25, Issue:14, 2017
Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors.ACS medicinal chemistry letters, , Sep-14, Volume: 8, Issue:9, 2017
Dual-tail approach to discovery of novel carbonic anhydrase IX inhibitors by simultaneously matching the hydrophobic and hydrophilic halves of the active site.European journal of medicinal chemistry, , May-26, Volume: 132, 2017
5-Substituted-benzylsulfanyl-thiophene-2-sulfonamides with effective carbonic anhydrase inhibitory activity: Solution and crystallographic investigations.Bioorganic & medicinal chemistry, , 02-01, Volume: 25, Issue:3, 2017
Development of 3-(4-aminosulphonyl)-phenyl-2-mercapto-3H-quinazolin-4-ones as inhibitors of carbonic anhydrase isoforms involved in tumorigenesis and glaucoma.Bioorganic & medicinal chemistry, , Mar-15, Volume: 24, Issue:6, 2016
Kinetic and X-ray crystallographic investigations on carbonic anhydrase isoforms I, II, IX and XII of a thioureido analog of SLC-0111.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma.Journal of medicinal chemistry, , 06-23, Volume: 59, Issue:12, 2016
Sulfonamides incorporating heteropolycyclic scaffolds show potent inhibitory action against carbonic anhydrase isoforms I, II, IX and XII.Bioorganic & medicinal chemistry, , Feb-15, Volume: 24, Issue:4, 2016
Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines.Bioorganic & medicinal chemistry, , 07-01, Volume: 24, Issue:13, 2016
PEGylated Bis-Sulfonamide Carbonic Anhydrase Inhibitors Can Efficiently Control the Growth of Several Carbonic Anhydrase IX-Expressing Carcinomas.Journal of medicinal chemistry, , 05-26, Volume: 59, Issue:10, 2016
Pyrazolylbenzo[d]imidazoles as new potent and selective inhibitors of carbonic anhydrase isoforms hCA IX and XII.Bioorganic & medicinal chemistry, , 07-01, Volume: 24, Issue:13, 2016
N-Nitrosulfonamides: A new chemotype for carbonic anhydrase inhibition.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1,6-dihydropyrimidine-benzenesulfonamides acting as carbonic anhydrase inhibitors.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Synthesis of 4-sulfamoylphenyl-benzylamine derivatives with inhibitory activity against human carbonic anhydrase isoforms I, II, IX and XII.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Synthesis and carbonic anhydrase inhibitory effects of new N-glycosylsulfonamides incorporating the phenol moiety.Bioorganic & medicinal chemistry letters, , 08-15, Volume: 26, Issue:16, 2016
An Unusual Natural Product Primary Sulfonamide: Synthesis, Carbonic Anhydrase Inhibition, and Protein X-ray Structures of Psammaplin C.Journal of medicinal chemistry, , 06-09, Volume: 59, Issue:11, 2016
Novel sulfonamide bearing coumarin scaffolds as selective inhibitors of tumor associated carbonic anhydrase isoforms IX and XII.Bioorganic & medicinal chemistry, , 07-01, Volume: 24, Issue:13, 2016
Amido/ureidosubstituted benzenesulfonamides-isatin conjugates as low nanomolar/subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform XII.European journal of medicinal chemistry, , Mar-03, Volume: 110, 2016
4-Arylbenzenesulfonamides as Human Carbonic Anhydrase Inhibitors (hCAIs): Synthesis by Pd Nanocatalyst-Mediated Suzuki-Miyaura Reaction, Enzyme Inhibition, and X-ray Crystallographic Studies.Journal of medicinal chemistry, , Jan-28, Volume: 59, Issue:2, 2016
Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins.Journal of medicinal chemistry, , Jan-14, Volume: 59, Issue:1, 2016
Fluorescent sulfonamide carbonic anhydrase inhibitors incorporating 1,2,3-triazole moieties: Kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , Jan-15, Volume: 24, Issue:2, 2016
Benzenesulfonamides Incorporating Flexible Triazole Moieties Are Highly Effective Carbonic Anhydrase Inhibitors: Synthesis and Kinetic, Crystallographic, Computational, and Intraocular Pressure Lowering Investigations.Journal of medicinal chemistry, , 12-08, Volume: 59, Issue:23, 2016
Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action.Bioorganic & medicinal chemistry, , Feb-15, Volume: 24, Issue:4, 2016
Carbonic Anhydrase Glycoinhibitors belonging to the Aminoxysulfonamide Series.ACS medicinal chemistry letters, , Jul-09, Volume: 6, Issue:7, 2015
Synthesis and carbonic anhydrase I, II, IX and XII inhibitory activity of sulfamates incorporating piperazinyl-ureido moieties.Bioorganic & medicinal chemistry, , Sep-01, Volume: 23, Issue:17, 2015
5-Aryl-1H-pyrazole-3-carboxylic acids as selective inhibitors of human carbonic anhydrases IX and XII.Bioorganic & medicinal chemistry, , Aug-01, Volume: 23, Issue:15, 2015
Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
New approaches to the synthesis of sildenafil analogues and their enzyme inhibitory activity.Bioorganic & medicinal chemistry, , Apr-01, Volume: 23, Issue:7, 2015
Synthesis of 6-aryl-substituted sulfocoumarins and investigation of their carbonic anhydrase inhibitory action.Bioorganic & medicinal chemistry, , Apr-01, Volume: 23, Issue:7, 2015
Synthesis and carbonic anhydrase isoenzymes I, II, IX, and XII inhibitory effects of dimethoxybromophenol derivatives incorporating cyclopropane moieties.Journal of medicinal chemistry, , Jan-22, Volume: 58, Issue:2, 2015
Synthesis of sulfonamides incorporating piperazinyl-ureido moieties and their carbonic anhydrase I, II, IX and XII inhibitory activity.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 25, Issue:18, 2015
Design and synthesis of benzothiazole-6-sulfonamides acting as highly potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII.Bioorganic & medicinal chemistry, , Aug-01, Volume: 23, Issue:15, 2015
6-Substituted sulfocoumarins are selective carbonic anhdydrase IX and XII inhibitors with significant cytotoxicity against colorectal cancer cells.Journal of medicinal chemistry, , May-14, Volume: 58, Issue:9, 2015
New amide derivatives of Probenecid as selective inhibitors of carbonic anhydrase IX and XII: biological evaluation and molecular modelling studies.Bioorganic & medicinal chemistry, , Jul-01, Volume: 23, Issue:13, 2015
Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors.Journal of medicinal chemistry, , Nov-12, Volume: 58, Issue:21, 2015
Isatin-pyrazole benzenesulfonamide hybrids potently inhibit tumor-associated carbonic anhydrase isoforms IX and XII.European journal of medicinal chemistry, , Oct-20, Volume: 103, 2015
Synthesis of novel acridine bis-sulfonamides with effective inhibitory activity against the carbonic anhydrase isoforms I, II, IX and XII.Bioorganic & medicinal chemistry, , Oct-15, Volume: 23, Issue:20, 2015
Phosphate Chemical Probes Designed for Location Specific Inhibition of Intracellular Carbonic Anhydrases.Journal of medicinal chemistry, , Sep-24, Volume: 58, Issue:18, 2015
Interaction of carbonic anhydrase isozymes I, II, and IX with some pyridine and phenol hydrazinecarbothioamide derivatives.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 25, Issue:23, 2015
Click-tailed coumarins with potent and selective inhibitory action against the tumor-associated carbonic anhydrases IX and XII.Bioorganic & medicinal chemistry, , Nov-01, Volume: 23, Issue:21, 2015
Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates.Journal of medicinal chemistry, , Aug-27, Volume: 58, Issue:16, 2015
New pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors.Bioorganic & medicinal chemistry, , Jul-01, Volume: 23, Issue:13, 2015
Synthesis, carbonic anhydrase inhibition and cytotoxic activity of novel chromone-based sulfonamide derivatives.European journal of medicinal chemistry, , Volume: 96, 2015
Exploring new Probenecid-based carbonic anhydrase inhibitors: Synthesis, biological evaluation and docking studies.Bioorganic & medicinal chemistry, , Sep-01, Volume: 23, Issue:17, 2015
Sulfonamide bearing pyrazolylpyrazolines as potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 25, Issue:16, 2015
New 4-[(3-cyclohexyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulfonamides, synthesis and inhibitory activity toward carbonic anhydrase I, II, IX, XII.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 25, Issue:16, 2015
Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry.ACS medicinal chemistry letters, , Aug-14, Volume: 5, Issue:8, 2014
Cyclic tertiary sulfamates: selective inhibition of the tumor-associated carbonic anhydrases IX and XII by N- and O-substituted acesulfame derivatives.European journal of medicinal chemistry, , Sep-12, Volume: 84, 2014
Flow synthesis and biological activity of aryl sulfonamides as selective carbonic anhydrase IX and XII inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 24, Issue:15, 2014
Ferrier sulfamidoglycosylation of glycals catalyzed by nitrosonium tetrafluoroborate: towards new carbonic anhydrase glycoinhibitors.Bioorganic & medicinal chemistry, , Nov-15, Volume: 22, Issue:22, 2014
A class of 4-sulfamoylphenyl-ω-aminoalkyl ethers with effective carbonic anhydrase inhibitory action and antiglaucoma effects.Journal of medicinal chemistry, , Nov-26, Volume: 57, Issue:22, 2014
Carbonic anhydrase inhibitors. Synthesis of a novel series of 5-substituted 2,4-dichlorobenzenesulfonamides and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII.European journal of medicinal chemistry, , Jul-23, Volume: 82, 2014
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 24, Issue:12, 2014
Synthesis and carbonic anhydrase I, II, IX and XII inhibition studies of 4-N,N-disubstituted sulfanilamides incorporating 4,4,4-trifluoro-3-oxo-but-1-enyl, phenacylthiourea and imidazol-2(3H)-one/thione moieties.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 24, Issue:7, 2014
Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 24, Issue:8, 2014
Design, synthesis and evaluation of N-substituted saccharin derivatives as selective inhibitors of tumor-associated carbonic anhydrase XII.Bioorganic & medicinal chemistry, , Mar-15, Volume: 22, Issue:6, 2014
Substituted benzene sulfonamides incorporating 1,3,5-triazinyl moieties potently inhibit human carbonic anhydrases II, IX and XII.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 24, Issue:5, 2014
Synthesis of 6-tetrazolyl-substituted sulfocoumarins acting as highly potent and selective inhibitors of the tumor-associated carbonic anhydrase isoforms IX and XII.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
Carbonic anhydrase inhibitors. Synthesis, and molecular structure of novel series N-substituted N'-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)guanidines and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associatEuropean journal of medicinal chemistry, , Volume: 71, 2014
Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , Jan-01, Volume: 22, Issue:1, 2014
Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors.European journal of medicinal chemistry, , Volume: 71, 2014
Synthesis of a new series of N⁴-substituted 4-(2-aminoethyl)benzenesulfonamides and their inhibitory effect on human carbonic anhydrase cytosolic isozymes I and II and transmembrane tumor-associated isozymes IX and XII.European journal of medicinal chemistry, , Sep-12, Volume: 84, 2014
4-Functionalized 1,3-diarylpyrazoles bearing 6-aminosulfonylbenzothiazole moiety as potent inhibitors of carbonic anhydrase isoforms hCA I, II, IX and XII.Bioorganic & medicinal chemistry, , Dec-15, Volume: 22, Issue:24, 2014
Carbonic anhydrase inhibitory activity of sulfonamides and carboxylic acids incorporating cyclic imide scaffolds.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 24, Issue:22, 2014
Carbonic anhydrase inhibitors: Synthesis, molecular docking, cytotoxic and inhibition of the human carbonic anhydrase isoforms I, II, IX, XII with novel benzenesulfonamides incorporating pyrrole, pyrrolopyrimidine and fused pyrrolopyrimidine moieties.Bioorganic & medicinal chemistry, , Jul-15, Volume: 22, Issue:14, 2014
6-Triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrases IX and XII.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 24, Issue:5, 2014
Carbonic anhydrase inhibitors: design, synthesis, and biological evaluation of novel sulfonyl semicarbazide derivatives.ACS medicinal chemistry letters, , Jul-10, Volume: 5, Issue:7, 2014
Selective inhibition of human carbonic anhydrases by novel amide derivatives of probenecid: synthesis, biological evaluation and molecular modelling studies.Bioorganic & medicinal chemistry, , Aug-01, Volume: 22, Issue:15, 2014
Structural insights on carbonic anhydrase inhibitory action, isoform selectivity, and potency of sulfonamides and coumarins incorporating arylsulfonylureido groups.Journal of medicinal chemistry, , Nov-13, Volume: 57, Issue:21, 2014
Inhibition of carbonic anhydrase isoforms I, II, IX and XII with novel Schiff bases: identification of selective inhibitors for the tumor-associated isoforms over the cytosolic ones.Bioorganic & medicinal chemistry, , Nov-01, Volume: 22, Issue:21, 2014
Novel sulfonamides bearing pyrrole and pyrrolopyrimidine moieties as carbonic anhydrase inhibitors: Synthesis, cytotoxic activity and molecular modeling.European journal of medicinal chemistry, , Nov-24, Volume: 87, 2014
4-Functionalized 1,3-diarylpyrazoles bearing benzenesulfonamide moiety as selective potent inhibitors of the tumor associated carbonic anhydrase isoforms IX and XII.European journal of medicinal chemistry, , Apr-09, Volume: 76, 2014
Inhibition studies of new ureido-substituted sulfonamides incorporating a GABA moiety against human carbonic anhydrase isoforms I-XIV.Bioorganic & medicinal chemistry, , Dec-15, Volume: 22, Issue:24, 2014
Pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors with antitumor activity.Bioorganic & medicinal chemistry, , May-01, Volume: 22, Issue:9, 2014
Benzenesulfonamide bearing 1,2,4-triazole scaffolds as potent inhibitors of tumor associated carbonic anhydrase isoforms hCA IX and hCA XII.Bioorganic & medicinal chemistry, , Mar-15, Volume: 22, Issue:6, 2014
Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX.Journal of medicinal chemistry, , Nov-26, Volume: 57, Issue:22, 2014
Salen and tetrahydrosalen derivatives act as effective inhibitors of the tumor-associated carbonic anhydrase XII--a new scaffold for designing isoform-selective inhibitors.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 23, Issue:24, 2013
A prodrug approach toward cancer-related carbonic anhydrase inhibition.Journal of medicinal chemistry, , Dec-12, Volume: 56, Issue:23, 2013
Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates.Journal of medicinal chemistry, , Nov-14, Volume: 56, Issue:21, 2013
Inhibition of tumor-associated human carbonic anhydrase isozymes IX and XII by a new class of substituted-phenylacetamido aromatic sulfonamides.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Synthesis and carbonic anhydrase inhibitory properties of sulfamides structurally related to dopamine.Bioorganic & medicinal chemistry, , Jun-01, Volume: 21, Issue:11, 2013
Xanthates and trithiocarbonates strongly inhibit carbonic anhydrases and show antiglaucoma effects in vivo.Journal of medicinal chemistry, , Jun-13, Volume: 56, Issue:11, 2013
Carbonic anhydrase inhibitors: benzenesulfonamides incorporating cyanoacrylamide moieties are low nanomolar/subnanomolar inhibitors of the tumor-associated isoforms IX and XII.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases.Journal of medicinal chemistry, , Jan-10, Volume: 56, Issue:1, 2013
Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases.Bioorganic & medicinal chemistry, , Nov-15, Volume: 21, Issue:22, 2013
Design and synthesis of novel 4-(4-oxo-2-arylthiazolidin-3-yl)benzenesulfonamides as selective inhibitors of carbonic anhydrase IX over I and II with potential anticancer activity.European journal of medicinal chemistry, , Volume: 66, 2013
7-Substituted-sulfocoumarins are isoform-selective, potent carbonic anhydrase II inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
New selective carbonic anhydrase IX inhibitors: synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 23, Issue:3, 2013
Effect of incorporating a thiophene tail in the scaffold of acetazolamide on the inhibition of human carbonic anhydrase isoforms I, II, IX and XII.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 23, Issue:20, 2013
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
5-Substituted-(1,2,3-triazol-4-yl)thiophene-2-sulfonamides strongly inhibit human carbonic anhydrases I, II, IX and XII: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Sulfonamides containing coumarin moieties selectively and potently inhibit carbonic anhydrases II and IX: design, synthesis, inhibitory activity and 3D-QSAR analysis.European journal of medicinal chemistry, , Volume: 66, 2013
Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including acetazolamide in human glioblastoma.Bioorganic & medicinal chemistry, , Jul-01, Volume: 21, Issue:13, 2013
Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition.Bioorganic & medicinal chemistry, , Apr-15, Volume: 21, Issue:8, 2013
Optimization of heterocyclic substituted benzenesulfonamides as novel carbonic anhydrase IX inhibitors and their structure activity relationship.European journal of medicinal chemistry, , Volume: 62, 2013
o-Benzenedisulfonimido-sulfonamides are potent inhibitors of the tumor-associated carbonic anhydrase isoforms CA IX and CA XII.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Metronidazole-coumarin conjugates and 3-cyano-7-hydroxy-coumarin act as isoform-selective carbonic anhydrase inhibitors.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Discovery of new potent inhibitors for carbonic anhydrase IX by structure-based virtual screening.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 23, Issue:12, 2013
Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups.Journal of medicinal chemistry, , Aug-09, Volume: 55, Issue:15, 2012
Inhibition of α-class cytosolic human carbonic anhydrases I, II, IX and XII, and β-class fungal enzymes by carboxylic acids and their derivatives: new isoform-I selective nanomolar inhibitors.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 22, Issue:18, 2012
Synthesis, structure-activity relationship studies, and X-ray crystallographic analysis of arylsulfonamides as potent carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Apr-26, Volume: 55, Issue:8, 2012
Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo.Journal of medicinal chemistry, , Feb-23, Volume: 55, Issue:4, 2012
Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases.Bioorganic & medicinal chemistry, , Apr-01, Volume: 20, Issue:7, 2012
Synthesis of glycoconjugate carbonic anhydrase inhibitors by ruthenium-catalysed azide-alkyne 1,3-dipolar cycloaddition.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 21, Issue:20, 2011
Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 21, Issue:19, 2011
Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , May-15, Volume: 19, Issue:10, 2011
Sulfonamides incorporating boroxazolidone moieties are potent inhibitors of the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII.Bioorganic & medicinal chemistry letters, , May-15, Volume: 21, Issue:10, 2011
Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitors.Journal of medicinal chemistry, , Oct-13, Volume: 54, Issue:19, 2011
Synthesis of rhodamine B-benzenesulfonamide conjugates and their inhibitory activity against human α- and bacterial/fungal β-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 21, Issue:18, 2011
Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 21, Issue:11, 2011
Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis.Journal of medicinal chemistry, , Mar-24, Volume: 54, Issue:6, 2011
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
New hydroxypyrimidinone-containing sulfonamides as carbonic anhydrase inhibitors also acting as MMP inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.European journal of medicinal chemistry, , Volume: 45, Issue:9, 2010
Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides.European journal of medicinal chemistry, , Volume: 45, Issue:6, 2010
Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations.Bioorganic & medicinal chemistry, , Jul-15, Volume: 18, Issue:14, 2010
Pteridine-sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity.Bioorganic & medicinal chemistry, , Jul-15, Volume: 18, Issue:14, 2010
Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases.Journal of medicinal chemistry, , Apr-08, Volume: 53, Issue:7, 2010
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies.Journal of medicinal chemistry, , Mar-25, Volume: 53, Issue:6, 2010
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Inhibition of carbonic anhydrase isozymes with benzene sulfonamides incorporating thio, sulfinyl and sulfonyl glycoside moieties.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 19, Issue:8, 2009
Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties.Biochemistry, , Feb-17, Volume: 48, Issue:6, 2009
Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors.Bioorganic & medicinal chemistry, , Jan-15, Volume: 17, Issue:2, 2009
S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases.Journal of medicinal chemistry, , Oct-22, Volume: 52, Issue:20, 2009
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell lines.Journal of enzyme inhibition and medicinal chemistry, , Volume: 24, Issue:2, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.Journal of medicinal chemistry, , Oct-08, Volume: 52, Issue:19, 2009
Carbonic anhydrase inhibitors; fluorinated phenyl sulfamates show strong inhibitory activity and selectivity for the inhibition of the tumor-associated isozymes IX and XII over the cytosolic ones I and II.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 19, Issue:17, 2009
The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 19, Issue:20, 2009
Synthesis and biological evaluation of a new family of anti-benzylanilinosulfonamides as CA IX inhibitors.European journal of medicinal chemistry, , Volume: 44, Issue:2, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Synthesis of 2,4,6-trimethylpyridinium derivatives of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides acting as potent inhibitors of the tumor-associated isoform IX and XII.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 19, Issue:11, 2009
Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the cytosolic isoforms I and II.Bioorganic & medicinal chemistry, , Oct-15, Volume: 17, Issue:20, 2009
The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 19, Issue:15, 2009
Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides.Journal of medicinal chemistry, , Mar-27, Volume: 51, Issue:6, 2008
Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 18, Issue:12, 2008
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 18, Issue:14, 2008
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates.Journal of medicinal chemistry, , Dec-25, Volume: 51, Issue:24, 2008
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 18, Issue:2, 2008
Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 18, Issue:6, 2008
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 17, Issue:6, 2007
Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose-thioureido tails.Bioorganic & medicinal chemistry letters, , May-15, Volume: 17, Issue:10, 2007
Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates.Bioorganic & medicinal chemistry, , Mar-15, Volume: 15, Issue:6, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Design, synthesis, and docking studies of new 1,3,4-thiadiazole-2-thione derivatives with carbonic anhydrase inhibitory activity.Bioorganic & medicinal chemistry, , Nov-15, Volume: 15, Issue:22, 2007
Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrase inhibitors. Inhibition studies of the human secretory isoform VI with anions.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 17, Issue:4, 2007
Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I and II, and extracellular isoforms IV, IX, and XII with sulfamides incorporating sugar moieties.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007
Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 16, Issue:18, 2006
Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX.Journal of medicinal chemistry, , May-04, Volume: 49, Issue:9, 2006
A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing".Journal of medicinal chemistry, , Nov-02, Volume: 49, Issue:22, 2006
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 16, Issue:2, 2006
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.Journal of medicinal chemistry, , Sep-07, Volume: 49, Issue:18, 2006
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo[b]thiophene 1,1-dioxide sulfonamides.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005
Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 15, Issue:12, 2005
Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: toward agents for boron neutron capture therapy of hypoxic tumoBioorganic & medicinal chemistry letters, , Jul-01, Volume: 15, Issue:13, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 15, Issue:12, 2005
Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.Journal of medicinal chemistry, , Jul-28, Volume: 48, Issue:15, 2005
Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 15, Issue:23, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Jan-17, Volume: 15, Issue:2, 2005
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.Journal of medicinal chemistry, , Jan-29, Volume: 47, Issue:3, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Feb-23, Volume: 14, Issue:4, 2004
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 14, Issue:12, 2004
Benzolamide is not a membrane-impermeant carbonic anhydrase inhibitor.Journal of enzyme inhibition and medicinal chemistry, , Volume: 19, Issue:3, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.Bioorganic & medicinal chemistry letters, , May-03, Volume: 14, Issue:9, 2004
Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX.Journal of medicinal chemistry, , Apr-22, Volume: 47, Issue:9, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates.Journal of medicinal chemistry, , Dec-04, Volume: 46, Issue:25, 2003
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Acetazolamide-like carbonic anhydrase inhibitors with topical ocular hypotensive activity.Journal of medicinal chemistry, , Jul-10, Volume: 35, Issue:14, 1992
Synthesis and physicochemical properties of thiadiazolo[3,2-a]pyrimidinesulfonamides and thiadiazolo[3,2-a]triazinesulfonamides as candidates for topically effective carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Volume: 30, Issue:11, 1987
N-Substituted sulfonamide carbonic anhydrase inhibitors with topical effects on intraocular pressure.Journal of medicinal chemistry, , Volume: 29, Issue:8, 1986
Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors.European journal of medicinal chemistry, , Jan-01, Volume: 209, 2021
Synthesis of bulky-tailed sulfonamides incorporating pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-1(5H)-yl) moieties and evaluation of their carbonic anhydrases I, II, IV and IX inhibitory effects.Bioorganic & medicinal chemistry, , 04-01, Volume: 25, Issue:7, 2017
A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects.Bioorganic & medicinal chemistry, , Apr-15, Volume: 23, Issue:8, 2015
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 21, Issue:19, 2011
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 16, Issue:2, 2006
Designed multiple ligands. An emerging drug discovery paradigm.Journal of medicinal chemistry, , Oct-20, Volume: 48, Issue:21, 2005
Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II.Journal of medicinal chemistry, , Sep-08, Volume: 48, Issue:18, 2005
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.Journal of medicinal chemistry, , Jan-29, Volume: 47, Issue:3, 2004
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrases inhibitory effects of new benzenesulfonamides synthesized by using superacid chemistry.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
[no title available]European journal of medicinal chemistry, , Jan-01, Volume: 143, 2018
Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors.ACS medicinal chemistry letters, , Sep-14, Volume: 8, Issue:9, 2017
Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies.Journal of enzyme inhibition and medicinal chemistry, , Volume: 29, Issue:4, 2014
Carbonic anhydrase inhibitors. Synthesis of a novel series of 5-substituted 2,4-dichlorobenzenesulfonamides and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII.European journal of medicinal chemistry, , Jul-23, Volume: 82, 2014
Carbonic anhydrase inhibitors. Synthesis, and molecular structure of novel series N-substituted N'-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)guanidines and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associatEuropean journal of medicinal chemistry, , Volume: 71, 2014
Synthesis of a new series of N⁴-substituted 4-(2-aminoethyl)benzenesulfonamides and their inhibitory effect on human carbonic anhydrase cytosolic isozymes I and II and transmembrane tumor-associated isozymes IX and XII.European journal of medicinal chemistry, , Sep-12, Volume: 84, 2014
Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups.Journal of medicinal chemistry, , Aug-09, Volume: 55, Issue:15, 2012
Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 21, Issue:19, 2011
Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , May-15, Volume: 19, Issue:10, 2011
Sulfonamides incorporating boroxazolidone moieties are potent inhibitors of the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII.Bioorganic & medicinal chemistry letters, , May-15, Volume: 21, Issue:10, 2011
Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 21, Issue:11, 2011
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.European journal of medicinal chemistry, , Volume: 45, Issue:9, 2010
Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides.European journal of medicinal chemistry, , Volume: 45, Issue:6, 2010
Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell lines.Journal of enzyme inhibition and medicinal chemistry, , Volume: 24, Issue:2, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Synthesis of 2,4,6-trimethylpyridinium derivatives of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides acting as potent inhibitors of the tumor-associated isoform IX and XII.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 19, Issue:11, 2009
Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides.Journal of medicinal chemistry, , Mar-27, Volume: 51, Issue:6, 2008
Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 18, Issue:12, 2008
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 17, Issue:6, 2007
Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates.Bioorganic & medicinal chemistry, , Mar-15, Volume: 15, Issue:6, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007
Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 16, Issue:18, 2006
A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing".Journal of medicinal chemistry, , Nov-02, Volume: 49, Issue:22, 2006
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 16, Issue:2, 2006
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.Journal of medicinal chemistry, , Sep-07, Volume: 49, Issue:18, 2006
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo[b]thiophene 1,1-dioxide sulfonamides.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 15, Issue:12, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 15, Issue:12, 2005
Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.Journal of medicinal chemistry, , Jul-28, Volume: 48, Issue:15, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Jan-17, Volume: 15, Issue:2, 2005
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.Journal of medicinal chemistry, , Jan-29, Volume: 47, Issue:3, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Feb-23, Volume: 14, Issue:4, 2004
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 14, Issue:12, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.Bioorganic & medicinal chemistry letters, , May-03, Volume: 14, Issue:9, 2004
Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX.Journal of medicinal chemistry, , Apr-22, Volume: 47, Issue:9, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
[no title available]European journal of medicinal chemistry, , Jan-01, Volume: 143, 2018
Novel benzoyl thioureido benzene sulfonamides as highly potent and selective inhibitors of carbonic anhydrase IX: optimization and bioactive studies.MedChemComm, , Dec-01, Volume: 9, Issue:12, 2018
Design and synthesis of benzothiazole-6-sulfonamides acting as highly potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII.Bioorganic & medicinal chemistry, , Aug-01, Volume: 23, Issue:15, 2015
Carbonic anhydrase inhibitors. Synthesis of a novel series of 5-substituted 2,4-dichlorobenzenesulfonamides and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII.European journal of medicinal chemistry, , Jul-23, Volume: 82, 2014
Substituted benzene sulfonamides incorporating 1,3,5-triazinyl moieties potently inhibit human carbonic anhydrases II, IX and XII.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 24, Issue:5, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
Carbonic anhydrase inhibitors. Synthesis, and molecular structure of novel series N-substituted N'-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)guanidines and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associatEuropean journal of medicinal chemistry, , Volume: 71, 2014
Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors.European journal of medicinal chemistry, , Volume: 71, 2014
Synthesis of a new series of N⁴-substituted 4-(2-aminoethyl)benzenesulfonamides and their inhibitory effect on human carbonic anhydrase cytosolic isozymes I and II and transmembrane tumor-associated isozymes IX and XII.European journal of medicinal chemistry, , Sep-12, Volume: 84, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Discovery of new potent inhibitors for carbonic anhydrase IX by structure-based virtual screening.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 23, Issue:12, 2013
Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups.Journal of medicinal chemistry, , Aug-09, Volume: 55, Issue:15, 2012
Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , May-15, Volume: 19, Issue:10, 2011
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
New hydroxypyrimidinone-containing sulfonamides as carbonic anhydrase inhibitors also acting as MMP inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.European journal of medicinal chemistry, , Volume: 45, Issue:9, 2010
Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides.European journal of medicinal chemistry, , Volume: 45, Issue:6, 2010
Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties.Biochemistry, , Feb-17, Volume: 48, Issue:6, 2009
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell lines.Journal of enzyme inhibition and medicinal chemistry, , Volume: 24, Issue:2, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Synthesis of 2,4,6-trimethylpyridinium derivatives of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides acting as potent inhibitors of the tumor-associated isoform IX and XII.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 19, Issue:11, 2009
Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides.Journal of medicinal chemistry, , Mar-27, Volume: 51, Issue:6, 2008
Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 18, Issue:12, 2008
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 18, Issue:2, 2008
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 17, Issue:6, 2007
Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates.Bioorganic & medicinal chemistry, , Mar-15, Volume: 15, Issue:6, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007
Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 16, Issue:18, 2006
A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing".Journal of medicinal chemistry, , Nov-02, Volume: 49, Issue:22, 2006
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.Journal of medicinal chemistry, , Sep-07, Volume: 49, Issue:18, 2006
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo[b]thiophene 1,1-dioxide sulfonamides.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 15, Issue:12, 2005
Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: toward agents for boron neutron capture therapy of hypoxic tumoBioorganic & medicinal chemistry letters, , Jul-01, Volume: 15, Issue:13, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 15, Issue:12, 2005
Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.Journal of medicinal chemistry, , Jul-28, Volume: 48, Issue:15, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Jan-17, Volume: 15, Issue:2, 2005
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 14, Issue:12, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.Bioorganic & medicinal chemistry letters, , May-03, Volume: 14, Issue:9, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates.Journal of medicinal chemistry, , Dec-04, Volume: 46, Issue:25, 2003
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrases inhibitory effects of new benzenesulfonamides synthesized by using superacid chemistry.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 17, Issue:6, 2007
N-hydroxyurea--a versatile zinc binding function in the design of metalloenzyme inhibitors.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 16, Issue:16, 2006
Benzimidazole design, synthesis, and docking to build selective carbonic anhydrase VA inhibitors.Bioorganic & medicinal chemistry, , 02-01, Volume: 26, Issue:3, 2018
Carbonic anhydrases inhibitory effects of new benzenesulfonamides synthesized by using superacid chemistry.Journal of enzyme inhibition and medicinal chemistry, , Volume: 27, Issue:6, 2012
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases.Bioorganic & medicinal chemistry, , Apr-01, Volume: 20, Issue:7, 2012
Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases.Journal of medicinal chemistry, , Apr-08, Volume: 53, Issue:7, 2010
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 14, Issue:12, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines.European journal of medicinal chemistry, , Apr-15, Volume: 168, 2019
[no title available]European journal of medicinal chemistry, , Jan-01, Volume: 143, 2018
Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors.ACS medicinal chemistry letters, , Sep-14, Volume: 8, Issue:9, 2017
Carbonic anhydrase inhibitors. Synthesis of a novel series of 5-substituted 2,4-dichlorobenzenesulfonamides and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII.European journal of medicinal chemistry, , Jul-23, Volume: 82, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
Carbonic anhydrase inhibitors. Synthesis, and molecular structure of novel series N-substituted N'-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)guanidines and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associatEuropean journal of medicinal chemistry, , Volume: 71, 2014
Synthesis of a new series of N⁴-substituted 4-(2-aminoethyl)benzenesulfonamides and their inhibitory effect on human carbonic anhydrase cytosolic isozymes I and II and transmembrane tumor-associated isozymes IX and XII.European journal of medicinal chemistry, , Sep-12, Volume: 84, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Optimization of heterocyclic substituted benzenesulfonamides as novel carbonic anhydrase IX inhibitors and their structure activity relationship.European journal of medicinal chemistry, , Volume: 62, 2013
Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.European journal of medicinal chemistry, , Volume: 45, Issue:9, 2010
Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides.European journal of medicinal chemistry, , Volume: 45, Issue:6, 2010
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell lines.Journal of enzyme inhibition and medicinal chemistry, , Volume: 24, Issue:2, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Synthesis of 2,4,6-trimethylpyridinium derivatives of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides acting as potent inhibitors of the tumor-associated isoform IX and XII.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 19, Issue:11, 2009
Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides.Journal of medicinal chemistry, , Mar-27, Volume: 51, Issue:6, 2008
Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 18, Issue:12, 2008
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 18, Issue:2, 2008
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 17, Issue:6, 2007
Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates.Bioorganic & medicinal chemistry, , Mar-15, Volume: 15, Issue:6, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007
Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 16, Issue:18, 2006
A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing".Journal of medicinal chemistry, , Nov-02, Volume: 49, Issue:22, 2006
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 16, Issue:2, 2006
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.Journal of medicinal chemistry, , Sep-07, Volume: 49, Issue:18, 2006
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo[b]thiophene 1,1-dioxide sulfonamides.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 15, Issue:12, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 15, Issue:12, 2005
Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.Journal of medicinal chemistry, , Jul-28, Volume: 48, Issue:15, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Jan-17, Volume: 15, Issue:2, 2005
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.Journal of medicinal chemistry, , Jan-29, Volume: 47, Issue:3, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Feb-23, Volume: 14, Issue:4, 2004
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 14, Issue:12, 2004
Benzolamide is not a membrane-impermeant carbonic anhydrase inhibitor.Journal of enzyme inhibition and medicinal chemistry, , Volume: 19, Issue:3, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.Bioorganic & medicinal chemistry letters, , May-03, Volume: 14, Issue:9, 2004
Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX.Journal of medicinal chemistry, , Apr-22, Volume: 47, Issue:9, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates.Journal of medicinal chemistry, , Dec-04, Volume: 46, Issue:25, 2003
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Synthesis and physicochemical properties of thiadiazolo[3,2-a]pyrimidinesulfonamides and thiadiazolo[3,2-a]triazinesulfonamides as candidates for topically effective carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Volume: 30, Issue:11, 1987
New amide derivatives of Probenecid as selective inhibitors of carbonic anhydrase IX and XII: biological evaluation and molecular modelling studies.Bioorganic & medicinal chemistry, , Jul-01, Volume: 23, Issue:13, 2015
Exploring new Probenecid-based carbonic anhydrase inhibitors: Synthesis, biological evaluation and docking studies.Bioorganic & medicinal chemistry, , Sep-01, Volume: 23, Issue:17, 2015
Selective inhibition of human carbonic anhydrases by novel amide derivatives of probenecid: synthesis, biological evaluation and molecular modelling studies.Bioorganic & medicinal chemistry, , Aug-01, Volume: 22, Issue:15, 2014
[no title available]Journal of medicinal chemistry, , 01-09, Volume: 63, Issue:1, 2020
"Seriously Sweet": Acesulfame K Exhibits Selective Inhibition Using Alternative Binding Modes in Carbonic Anhydrase Isoforms.Journal of medicinal chemistry, , 02-08, Volume: 61, Issue:3, 2018
Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose.ACS medicinal chemistry letters, , Jul-12, Volume: 9, Issue:7, 2018
N-Substituted and ring opened saccharin derivatives selectively inhibit transmembrane, tumor-associated carbonic anhydrases IX and XII.Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
1,2-Benzisothiazole Derivatives Bearing 4-, 5-, or 6-Alkyl/arylcarboxamide Moieties Inhibit Carbonic Anhydrase Isoform IX (CAIX) and Cell Proliferation under Hypoxic Conditions.Journal of medicinal chemistry, , 07-14, Volume: 59, Issue:13, 2016
A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Cyclic secondary sulfonamides: unusually good inhibitors of cancer-related carbonic anhydrase enzymes.Journal of medicinal chemistry, , Apr-24, Volume: 57, Issue:8, 2014
Design, synthesis and evaluation of N-substituted saccharin derivatives as selective inhibitors of tumor-associated carbonic anhydrase XII.Bioorganic & medicinal chemistry, , Mar-15, Volume: 22, Issue:6, 2014
Purification and characterization of carbonic anhydrase from sheep kidney and effects of sulfonamides on enzyme activity.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 18, Issue:2, 2008
Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective.European journal of medicinal chemistry, , Jan-15, Volume: 210, 2021
Carbonic Anhydrase XII Inhibitors Overcome Temozolomide Resistance in Glioblastoma.Journal of medicinal chemistry, , 04-25, Volume: 62, Issue:8, 2019
Development of sulfonamides incorporating phenylacrylamido functionalities as carbonic anhydrase isoforms I, II, IX and XII inhibitors.Bioorganic & medicinal chemistry, , 10-15, Volume: 25, Issue:20, 2017
Dual-tail approach to discovery of novel carbonic anhydrase IX inhibitors by simultaneously matching the hydrophobic and hydrophilic halves of the active site.European journal of medicinal chemistry, , May-26, Volume: 132, 2017
Synthesis and carbonic anhydrase I, II, IX and XII inhibition studies of 4-N,N-disubstituted sulfanilamides incorporating 4,4,4-trifluoro-3-oxo-but-1-enyl, phenacylthiourea and imidazol-2(3H)-one/thione moieties.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 24, Issue:7, 2014
Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , Jan-01, Volume: 22, Issue:1, 2014
Superacid synthesis of halogen containing N-substituted-4-aminobenzene sulfonamides: new selective tumor-associated carbonic anhydrase inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Sulfonamides containing coumarin moieties selectively and potently inhibit carbonic anhydrases II and IX: design, synthesis, inhibitory activity and 3D-QSAR analysis.European journal of medicinal chemistry, , Volume: 66, 2013
Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases.Bioorganic & medicinal chemistry, , Apr-01, Volume: 20, Issue:7, 2012
Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 21, Issue:19, 2011
Sulfonamides incorporating boroxazolidone moieties are potent inhibitors of the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII.Bioorganic & medicinal chemistry letters, , May-15, Volume: 21, Issue:10, 2011
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 18, Issue:2, 2008
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: toward agents for boron neutron capture therapy of hypoxic tumoBioorganic & medicinal chemistry letters, , Jul-01, Volume: 15, Issue:13, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Jan-17, Volume: 15, Issue:2, 2005
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 14, Issue:12, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 17, Issue:6, 2007
Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.Journal of medicinal chemistry, , Sep-07, Volume: 49, Issue:18, 2006
Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II.Journal of medicinal chemistry, , Sep-08, Volume: 48, Issue:18, 2005
Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?Chemical biology & drug design, , Volume: 74, Issue:3, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 17, Issue:17, 2007
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Substituted thieno[2,3-b]thiophenes and related congeners: Synthesis, β-glucuronidase inhibition activity, crystal structure, and POM analyses.Bioorganic & medicinal chemistry, , Dec-01, Volume: 22, Issue:23, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Synthesis, structure-activity relationship studies, and X-ray crystallographic analysis of arylsulfonamides as potent carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Apr-26, Volume: 55, Issue:8, 2012
Synthesis and biological profile of new 1,2,3,4-tetrahydroisoquinolines as selective carbonic anhydrase inhibitors.Bioorganic & medicinal chemistry, , Dec-01, Volume: 19, Issue:23, 2011
Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies.Journal of medicinal chemistry, , Mar-25, Volume: 53, Issue:6, 2010
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?Chemical biology & drug design, , Volume: 74, Issue:3, 2009
S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases.Journal of medicinal chemistry, , Oct-22, Volume: 52, Issue:20, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 17, Issue:6, 2007
Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.Journal of medicinal chemistry, , Sep-07, Volume: 49, Issue:18, 2006
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 17, Issue:6, 2007
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose.ACS medicinal chemistry letters, , Jul-12, Volume: 9, Issue:7, 2018
Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates.Journal of medicinal chemistry, , Aug-27, Volume: 58, Issue:16, 2015
Heterocoumarins Are Selective Carbonic Anhydrase IX and XII Inhibitors with Cytotoxic Effects against Cancer Cells Lines.ACS medicinal chemistry letters, , Sep-13, Volume: 9, Issue:9, 2018
New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 22, Issue:6, 2012
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Carbonic anhydrase activators: activation of human isozymes I, II and IX with phenylsulfonylhydrazido l-histidine derivatives.Bioorganic & medicinal chemistry letters, , May-01, Volume: 19, Issue:9, 2009
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Discovery of novel aminosaccharide-based sulfonamide derivatives as potential carbonic anhydrase II inhibitors.Bioorganic & medicinal chemistry letters, , 12-01, Volume: 53, 2021
Novel carbohydrate-based sulfonamide derivatives as selective carbonic anhydrase II inhibitors: Synthesis, biological and molecular docking analysis.Bioorganic & medicinal chemistry letters, , 11-01, Volume: 51, 2021
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 14, Issue:12, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.Bioorganic & medicinal chemistry, , Aug-15, Volume: 17, Issue:16, 2009
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 24, Issue:12, 2014
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 15, Issue:6, 2005
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Benzolamide is not a membrane-impermeant carbonic anhydrase inhibitor.Journal of enzyme inhibition and medicinal chemistry, , Volume: 19, Issue:3, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 17, Issue:8, 2007
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Bortezomib inhibits mammalian carbonic anhydrases.Bioorganic & medicinal chemistry, , 10-01, Volume: 25, Issue:19, 2017
Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 17, Issue:6, 2007
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 14, Issue:12, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Superacid synthesis of halogen containing N-substituted-4-aminobenzene sulfonamides: new selective tumor-associated carbonic anhydrase inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 14, Issue:12, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 24, Issue:12, 2014
Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 24, Issue:8, 2014
Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines.European journal of medicinal chemistry, , Apr-15, Volume: 168, 2019
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases.Bioorganic & medicinal chemistry, , Nov-15, Volume: 21, Issue:22, 2013
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Inhibition of carbonic anhydrase isozymes with benzene sulfonamides incorporating thio, sulfinyl and sulfonyl glycoside moieties.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 19, Issue:8, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides.Journal of medicinal chemistry, , Mar-27, Volume: 51, Issue:6, 2008
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007
A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing".Journal of medicinal chemistry, , Nov-02, Volume: 49, Issue:22, 2006
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 15, Issue:12, 2005
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 14, Issue:12, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.Bioorganic & medicinal chemistry letters, , May-03, Volume: 14, Issue:9, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 14, Issue:12, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 14, Issue:12, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 17, Issue:6, 2007
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site.Bioorganic & medicinal chemistry, , Feb-15, Volume: 19, Issue:4, 2011
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Design, synthesis, and docking studies of new 1,3,4-thiadiazole-2-thione derivatives with carbonic anhydrase inhibitory activity.Bioorganic & medicinal chemistry, , Nov-15, Volume: 15, Issue:22, 2007
Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Jan-17, Volume: 15, Issue:2, 2005
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 14, Issue:12, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 21, Issue:19, 2011
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 16, Issue:2, 2006
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.Journal of medicinal chemistry, , Jan-29, Volume: 47, Issue:3, 2004
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II.Journal of medicinal chemistry, , Sep-08, Volume: 48, Issue:18, 2005
Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 15, Issue:23, 2005
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 14, Issue:12, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties.Biochemistry, , Feb-17, Volume: 48, Issue:6, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic Anhydrase XII Inhibitors Overcome Temozolomide Resistance in Glioblastoma.Journal of medicinal chemistry, , 04-25, Volume: 62, Issue:8, 2019
Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases.Bioorganic & medicinal chemistry, , Apr-01, Volume: 20, Issue:7, 2012
Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases.Journal of medicinal chemistry, , Apr-08, Volume: 53, Issue:7, 2010
Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors.Bioorganic & medicinal chemistry, , Jan-15, Volume: 17, Issue:2, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.Journal of medicinal chemistry, , Jul-28, Volume: 48, Issue:15, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 14, Issue:12, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Comprehensive study on potent and selective carbonic anhydrase inhibitors: Synthesis, bioactivities and molecular modelling studies of 4-(3-(2-arylidenehydrazine-1-carbonyl)-5-(thiophen-2-yl)-1H-pyrazole-1-yl) benzenesulfonamides.European journal of medicinal chemistry, , May-05, Volume: 217, 2021
Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines.European journal of medicinal chemistry, , Apr-15, Volume: 168, 2019
Carbonic anhydrase inhibitors. Synthesis of a novel series of 5-substituted 2,4-dichlorobenzenesulfonamides and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII.European journal of medicinal chemistry, , Jul-23, Volume: 82, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
Carbonic anhydrase inhibitors. Synthesis, and molecular structure of novel series N-substituted N'-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)guanidines and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associatEuropean journal of medicinal chemistry, , Volume: 71, 2014
Synthesis of a new series of N⁴-substituted 4-(2-aminoethyl)benzenesulfonamides and their inhibitory effect on human carbonic anhydrase cytosolic isozymes I and II and transmembrane tumor-associated isozymes IX and XII.European journal of medicinal chemistry, , Sep-12, Volume: 84, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.European journal of medicinal chemistry, , Volume: 46, Issue:9, 2011
New hydroxypyrimidinone-containing sulfonamides as carbonic anhydrase inhibitors also acting as MMP inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.European journal of medicinal chemistry, , Volume: 45, Issue:9, 2010
Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides.European journal of medicinal chemistry, , Volume: 45, Issue:6, 2010
Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell lines.Journal of enzyme inhibition and medicinal chemistry, , Volume: 24, Issue:2, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides.Journal of medicinal chemistry, , Mar-27, Volume: 51, Issue:6, 2008
Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 18, Issue:12, 2008
Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 17, Issue:6, 2007
Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates.Bioorganic & medicinal chemistry, , Mar-15, Volume: 15, Issue:6, 2007
Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007
Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 16, Issue:18, 2006
A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing".Journal of medicinal chemistry, , Nov-02, Volume: 49, Issue:22, 2006
Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.Journal of medicinal chemistry, , Sep-07, Volume: 49, Issue:18, 2006
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo[b]thiophene 1,1-dioxide sulfonamides.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005
Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II.Journal of medicinal chemistry, , Sep-08, Volume: 48, Issue:18, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 15, Issue:12, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 15, Issue:12, 2005
Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.Journal of medicinal chemistry, , Jul-28, Volume: 48, Issue:15, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Feb-23, Volume: 14, Issue:4, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.Bioorganic & medicinal chemistry letters, , May-03, Volume: 14, Issue:9, 2004
Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX.Journal of medicinal chemistry, , Apr-22, Volume: 47, Issue:9, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail/dual-tail approaches as novel carbonic anhydrase inhibitors.European journal of medicinal chemistry, , Aug-05, Volume: 238, 2022
One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes.Journal of medicinal chemistry, , 01-13, Volume: 65, Issue:1, 2022
Natural inspired ligustrazine-based SLC-0111 analogues as novel carbonic anhydrase inhibitors.European journal of medicinal chemistry, , Jan-15, Volume: 228, 2022
Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors.European journal of medicinal chemistry, , Jan-01, Volume: 209, 2021
Natural inspired piperine-based sulfonamides and carboxylic acids as carbonic anhydrase inhibitors: Design, synthesis and biological evaluation.European journal of medicinal chemistry, , Dec-05, Volume: 225, 2021
Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer.Journal of medicinal chemistry, , 02-11, Volume: 64, Issue:3, 2021
Identification of N-phenyl-2-(phenylsulfonyl)acetamides/propanamides as new SLC-0111 analogues: Synthesis and evaluation of the carbonic anhydrase inhibitory activities.European journal of medicinal chemistry, , Jun-05, Volume: 218, 2021
[no title available]ACS medicinal chemistry letters, , May-14, Volume: 11, Issue:5, 2020
[no title available]Journal of medicinal chemistry, , 01-09, Volume: 63, Issue:1, 2020
Synthesis, biological and molecular dynamics investigations with a series of triazolopyrimidine/triazole-based benzenesulfonamides as novel carbonic anhydrase inhibitors.European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
Discovery of new ureido benzenesulfonamides incorporating 1,3,5-triazine moieties as carbonic anhydrase I, II, IX and XII inhibitors.Bioorganic & medicinal chemistry, , 04-15, Volume: 27, Issue:8, 2019
New anthranilic acid-incorporating N-benzenesulfonamidophthalimides as potent inhibitors of carbonic anhydrases I, II, IX, and XII: Synthesis, in vitro testing, and in silico assessment.European journal of medicinal chemistry, , Nov-01, Volume: 181, 2019
Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents.European journal of medicinal chemistry, , Jan-15, Volume: 162, 2019
Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX.Journal of medicinal chemistry, , 07-26, Volume: 61, Issue:14, 2018
Synthesis of novel acyl selenoureido benzensulfonamides as carbonic anhydrase I, II, VII and IX inhibitors.Bioorganic & medicinal chemistry, , 07-01, Volume: 25, Issue:13, 2017
Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors.ACS medicinal chemistry letters, , Sep-14, Volume: 8, Issue:9, 2017
Synthesis and carbonic anhydrase inhibition of a series of SLC-0111 analogs.Bioorganic & medicinal chemistry, , 05-01, Volume: 25, Issue:9, 2017
Kinetic and X-ray crystallographic investigations on carbonic anhydrase isoforms I, II, IX and XII of a thioureido analog of SLC-0111.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines.Bioorganic & medicinal chemistry, , 07-01, Volume: 24, Issue:13, 2016
Amido/ureidosubstituted benzenesulfonamides-isatin conjugates as low nanomolar/subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform XII.European journal of medicinal chemistry, , Mar-03, Volume: 110, 2016
Synthesis of sulfonamides incorporating piperazinyl-ureido moieties and their carbonic anhydrase I, II, IX and XII inhibitory activity.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 25, Issue:18, 2015
Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis.Journal of medicinal chemistry, , Mar-24, Volume: 54, Issue:6, 2011
Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.Journal of medicinal chemistry, , Sep-07, Volume: 49, Issue:18, 2006
Design, synthesis & biological evaluation of ferulic acid-based small molecule inhibitors against tumor-associated carbonic anhydrase IX.Bioorganic & medicinal chemistry, , 05-01, Volume: 28, Issue:9, 2020
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo.Journal of medicinal chemistry, , Feb-23, Volume: 55, Issue:4, 2012
Carbonic anhydrase inhibitors. Inhibition of transmembrane isoforms IX, XII, and XIV with less investigated anions including trithiocarbonate and dithiocarbamate.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 20, Issue:5, 2010
5- and 6-membered (thio)lactones are prodrug type carbonic anhydrase inhibitors.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 22, Issue:1, 2012
Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site.Bioorganic & medicinal chemistry, , Feb-15, Volume: 19, Issue:4, 2011
Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Inhibition of carbonic anhydrase isozymes with benzene sulfonamides incorporating thio, sulfinyl and sulfonyl glycoside moieties.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 19, Issue:8, 2009
Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.Journal of medicinal chemistry, , Apr-05, Volume: 50, Issue:7, 2007
Inhibitory effects and structural insights for a novel series of coumarin-based compounds that selectively target human CA IX and CA XII carbonic anhydrases.European journal of medicinal chemistry, , Jan-01, Volume: 143, 2018
Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins.Journal of medicinal chemistry, , Jan-14, Volume: 59, Issue:1, 2016
Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.Journal of medicinal chemistry, , Dec-22, Volume: 54, Issue:24, 2011
Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 20, Issue:24, 2010
Natural product coumarins that inhibit human carbonic anhydrases.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines.European journal of medicinal chemistry, , Apr-15, Volume: 168, 2019
Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy.Journal of medicinal chemistry, , 06-28, Volume: 61, Issue:12, 2018
Cyclodextrin complexation highly enhances efficacy of arylsulfonylureido benzenesulfonamide carbonic anhydrase inhibitors as a topical antiglaucoma agents.Bioorganic & medicinal chemistry, , Sep-15, Volume: 23, Issue:18, 2015
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases.Bioorganic & medicinal chemistry, , Nov-15, Volume: 21, Issue:22, 2013
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 21, Issue:11, 2011
Inhibition of carbonic anhydrase isozymes with benzene sulfonamides incorporating thio, sulfinyl and sulfonyl glycoside moieties.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 19, Issue:8, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.Journal of medicinal chemistry, , Oct-08, Volume: 52, Issue:19, 2009
Carbonic anhydrase inhibitors; fluorinated phenyl sulfamates show strong inhibitory activity and selectivity for the inhibition of the tumor-associated isozymes IX and XII over the cytosolic ones I and II.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 19, Issue:17, 2009
Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the cytosolic isoforms I and II.Bioorganic & medicinal chemistry, , Oct-15, Volume: 17, Issue:20, 2009
Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides.Journal of medicinal chemistry, , Mar-27, Volume: 51, Issue:6, 2008
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 16, Issue:2, 2006
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 15, Issue:12, 2005
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Jan-17, Volume: 15, Issue:2, 2005
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, , Jul-16, Volume: 14, Issue:14, 2004
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.Journal of medicinal chemistry, , Jan-29, Volume: 47, Issue:3, 2004
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 14, Issue:12, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.Bioorganic & medicinal chemistry letters, , May-03, Volume: 14, Issue:9, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Design, synthesis and biochemical evaluation of novel carbonic anhydrase inhibitors triggered by structural knowledge on hCA VII.Bioorganic & medicinal chemistry, , 08-15, Volume: 44, 2021
Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety.European journal of medicinal chemistry, , Feb-01, Volume: 163, 2019
Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology.ACS medicinal chemistry letters, , May-10, Volume: 9, Issue:5, 2018
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.Bioorganic & medicinal chemistry, , Oct-01, Volume: 21, Issue:19, 2013
Synthesis, structure-activity relationship studies, and X-ray crystallographic analysis of arylsulfonamides as potent carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Apr-26, Volume: 55, Issue:8, 2012
Design, synthesis, and biological evaluation of novel carbohydrate-based sulfamates as carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Mar-10, Volume: 54, Issue:5, 2011
N-β-glycosyl sulfamides are selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 21, Issue:15, 2011
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases.Journal of medicinal chemistry, , Apr-08, Volume: 53, Issue:7, 2010
Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies.Journal of medicinal chemistry, , Mar-25, Volume: 53, Issue:6, 2010
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases.Journal of medicinal chemistry, , Oct-22, Volume: 52, Issue:20, 2009
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Synthesis and evaluation of pharmacological profile of 1-aryl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamides.Bioorganic & medicinal chemistry, , May-15, Volume: 17, Issue:10, 2009
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose-thioureido tails.Bioorganic & medicinal chemistry letters, , May-15, Volume: 17, Issue:10, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I and II, and extracellular isoforms IV, IX, and XII with sulfamides incorporating sugar moieties.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 17, Issue:18, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II.Journal of medicinal chemistry, , Sep-08, Volume: 48, Issue:18, 2005
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.Bioorganic & medicinal chemistry letters, , Dec-20, Volume: 14, Issue:24, 2004
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.Journal of medicinal chemistry, , Feb-12, Volume: 52, Issue:3, 2009
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Jun-21, Volume: 14, Issue:12, 2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, , Mar-24, Volume: 13, Issue:6, 2003
"Seriously Sweet": Acesulfame K Exhibits Selective Inhibition Using Alternative Binding Modes in Carbonic Anhydrase Isoforms.Journal of medicinal chemistry, , 02-08, Volume: 61, Issue:3, 2018
A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Cyclic tertiary sulfamates: selective inhibition of the tumor-associated carbonic anhydrases IX and XII by N- and O-substituted acesulfame derivatives.European journal of medicinal chemistry, , Sep-12, Volume: 84, 2014
Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins.Journal of medicinal chemistry, , Jan-14, Volume: 59, Issue:1, 2016
Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|
| carbonate dehydratase activity | molecular function | Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O. [EC:4.2.1.1] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
| molecular function activator activity | molecular function | A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target. [GOC:curators] |
Located In
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|
| nucleolus | cellular component | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. [ISBN:0198506732] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| basolateral plasma membrane | cellular component | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
| microvillus membrane | cellular component | The portion of the plasma membrane surrounding a microvillus. [GOC:mah] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Involved In
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|
| response to hypoxia | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:hjd] |
| morphogenesis of an epithelium | biological process | The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] |
| response to xenobiotic stimulus | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc] |
| response to testosterone | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus. [GOC:sl] |
| secretion | biological process | The controlled release of a substance by a cell or a tissue. [GOC:ai] |
| one-carbon metabolic process | biological process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. [GOC:hjd, GOC:mah, GOC:pde] |